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Katja Nagler, Antonina O Krawczyk, Anne De Jong, Kazimierz Madela, Tamara Hoffmann, Michael Laue, Oscar P Kuipers, Erhard Bremer, Ralf Moeller
In its natural habitat, the soil bacterium Bacillus subtilis often has to cope with fluctuating osmolality and nutrient availability. Upon nutrient depletion it can form dormant spores, which can revive to form vegetative cells when nutrients become available again. While the effects of salt stress on spore germination have been analyzed previously, detailed knowledge on the salt stress response during the subsequent outgrowth phase is lacking. In this study, we investigated the changes in gene expression during B...
2016: Frontiers in Microbiology
James M Bjork, Thomas K Burroughs, Laura M Franke, Treven C Pickett, Sade E Johns, F Gerard Moeller, William C Walker
In military populations, traumatic brain injury (TBI) also holds potential to increase impulsivity and impair mood regulation due to blast injury effects on ventral frontal cortex - to put military personnel at risk for suicide or substance abuse. We assessed a linkage between depression and impaired behavioral inhibition in 117 blast-exposed service members (SM) and veterans with post-concussion syndrome (PCS), where PCS was defined using a Rivermead Postconcussive Symptom Questionnaire (RPQ) modified to clarify whether each symptom worsened compared to pre-blast...
October 7, 2016: Psychiatry Research
Rutger J Maas, Jeroen K Deegens, Bart Smeets, Marcus J Moeller, Jack F Wetzels
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the key histological findings in patients with idiopathic nephrotic syndrome (INS). Although MCD and idiopathic FSGS are often considered to represent separate entities based on differences in their presenting characteristics, histology and outcomes, little evidence exists for this separation. We propose that MCD and idiopathic FSGS are different manifestations of the same progressive disease. The gradual development of FSGS in patients with non-remitting or relapsing INS has been well documented...
October 17, 2016: Nature Reviews. Nephrology
Maja Turinek, Martina Bavec, Milan Repič, Matjaž Turinek, Andreja Urbanek Krajnc, Christian Moellers, Alba Tres, Franc Bavec
BACKGROUND: Organic production is widely assumed to affect quality and nutritional parameters of arable crops. A field experiment was started in 2009 following integrated (INT), organic (ORG) and biodynamic (BD) production standards for wheat, maize and rapeseed production. With resort to standard analytical procedures and chemometrics compositional parameters of Brassica napus L. 'Siska' seed (water, protein, oil and glucosinolate content) by non-destructive near-infrared spectroscopy (NIRS), and fatty acid composition determined by gas chromatography, were assessed...
October 14, 2016: Journal of the Science of Food and Agriculture
Gabriela Gan, Rebecca N Preston-Campbell, Scott J Moeller, Joel L Steinberg, Scott D Lane, Thomas Maloney, Muhammad A Parvaz, Rita Z Goldstein, Nelly Alia-Klein
The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings...
2016: Frontiers in Behavioral Neuroscience
Soeren Latteyer, Vera Tiedje, Katharina König, Saskia Ting, Lukas C Heukamp, Lydia Meder, Kurt Werner Schmid, Dagmar Führer, Lars Christian Moeller
Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a median survival of 4-6 months. Identification of mutations contributing to aberrant activation of signaling cascades in ATC may provide novel opportunities for targeted therapy. Thirty-nine ATC samples were studied by next-generation sequencing (NGS) with an established gene panel. High quality readout was obtained in 30/39 ATC. Twenty-eight ATC harbored a mutation in at least one of the studied genes: TP53 (18/30), NF1 (11/30), ALK (6/30), NRAS (4/30), ATRX (3/30), BRAF (2/30), HRAS (2/30), KRAS (1/30)...
October 1, 2016: Endocrine
Kristen Moeller-Saxone, Louise McCutcheon, Stephen Halperin, Helen Herrman, Andrew M Chanen
BACKGROUND: Young people in out-of-home care, especially those with a history of multiple placements, typically have numerous and complex health needs, and worse health outcomes than their peers who grow up within a family of origin. A significant proportion of this can be attributed to policy failures and poor interagency communication. OBJECTIVE: The objective of this article is to describe the factors that contribute to the health needs of young people in out-of-home care and the tools available to support general practitioners (GPs) to provide care...
October 2016: Australian Family Physician
Claudia R Oliva, Tahireh Markert, Larry J Ross, E Lucile White, Lynn Rasmussen, Wei Zhang, Maaike Everts, Douglas R Moellering, Shannon M Bailey, Mark J Suto, Corinne E Griguer
The enzyme cytochrome c oxidase (CcO), or complex IV (EC, is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic to oxidative phosphorylation (OXPHOS) metabolism and has been associated with increased self-renewal characteristics in gliomas. Increased CcO activity in tumors has been associated with tumor progression after chemotherapy failure, and patients with primary glioblastoma multiforme and high tumor CcO activity have worse clinical outcomes than those with low tumor CcO activity...
September 27, 2016: Journal of Biological Chemistry
Konstantinos N Fountoulakis, Eduard Vieta, Allan Young, Lakshmi Yatham, Heinz Grunze, Pierre Blier, Hans Jurgen Moeller, Siegfried Kasper
BACKGROUND: The current fourth paper on the International College of Neuropsychopharmacology guidelines for the treatment of bipolar disorder reports on the unmet needs that became apparent after an extensive review of the literature and also serves as a conclusion to the project of the International College of Neuropsychopharmacology workgroup. MATERIALS AND METHODS: The systematic review of the literature that was performed to develop the International College of Neuropsychopharmacology guidelines for bipolar disorder identified and classified a number of potential shortcomings...
October 11, 2016: International Journal of Neuropsychopharmacology
C J Hampton, M Robinson, R D Foster, M Bright, J Symanowski, K Mileham, S H Burri, B J Moeller, J H Heinzerling
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
R H Press, S H Burri, D Boselli, J Symanowski, K Patel, S Lankford, R J McCammon, B J Moeller, J H Heinzerling, C Fasola, A L Asher, A Sumrall, W J Curran, H K Shu, I R Crocker, R S Prabhu
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Jaclyn R Moeller, David D Gummin, Tom J Nelson, Amy L Drendel, Breanne K Shah, Stuart Berger
OBJECTIVES: To evaluate the use of ondansetron in a tertiary care pediatric health system, assess the incidence of ventricular tachyarrhythmia within 24 hours of ondansetron, and identify the characteristics of children experiencing a ventricular tachyarrhythmia after ondansetron, to identify potential risk factors. STUDY DESIGN: This retrospective chart review identified children ≤18 years of age who received ondansetron within 24 hours prior to a ventricular tachyarrhythmia...
September 21, 2016: Journal of Pediatrics
Philippe Emge, Jens Moeller, Hongchul Jang, Roberto Rusconi, Yutaka Yawata, Roman Stocker, Viola Vogel
Quorum sensing (QS) is a population-density dependent chemical process that enables bacteria to communicate based on the production, secretion and sensing of small inducer molecules. While recombinant constructs have been widely used to decipher the molecular details of QS, how those findings translate to natural QS systems has remained an open question. Here, we compare the activation of natural and synthetic Pseudomonas aeruginosa LasI/R QS systems in bacteria exposed to quiescent conditions and controlled flows...
2016: Scientific Reports
Markus J Kettel, Elisabeth Heine, Karola Schaefer, Martin Moeller
Antimicrobial nanogels, aggregates, and films are prepared by complexation of the antiseptic and bacteriostatic agent chlorhexidine (CHX) for medical and dental applications. A series of α-, β-, and γ-cyclodextrin methacrylate (CD-MA) containing hydrophobic poly(methyl methacrylate) (PMMA) based nanogels are loaded quantitatively with CHX in aqueous dispersion. The results show that CHX is enhancedly complexed by the use of CD-MA domains in the particles structure. β-CD-MA nanogels present the highest uptake of CHX...
September 20, 2016: Macromolecular Bioscience
Julia Felicitas Dietrich, Stefan Huber, Elise Klein, Klaus Willmes, Silvia Pixner, Korbinian Moeller
The approximate number system (ANS) was proposed to be a building block for later mathematical abilities. Several measures have been used interchangeably to assess ANS acuity. Some of these measures were based on accuracy data, whereas others relied on response time (RT) data or combined accuracy and RT data. Previous studies challenged the view that all these measures can be used interchangeably, because low correlations between some of the measures had been observed. These low correlations might be due to poor reliability of some of the measures, since the majority of these measures are mathematically related...
2016: PloS One
Tarini Singh, Birte Moeller, Christian Frings
Binding theories assume that a stimulus and a response made to it are bound together, as in the case of the theory of event coding, in an event file (Hommel, Müsseler, Aschersleben, & Prinz, Behavioral and Brain Sciences, 24(05), 849-937, 2001). This binding occurs after even a single encounter with the stimulus and the response. Repeating any part of the event file will cause the entire file to be retrieved. However not only are relevant stimuli bound with responses but even irrelevant stimuli that co-occur with the target can be bound with the response, and repeating such a distractor will result in the event file being retrieved...
September 8, 2016: Attention, Perception & Psychophysics
Dennis Go, Philipp Lott, Jochen Stollenwerk, Helga Thomas, Martin Möller, Alexander J C Kuehne
Here we present a novel laser process to generate carbon nanofiber nonwovens from polyacrylonitrile. We produce carbon nanofabrics via electrospinning followed by infrared laser-induced carbonization, facilitating high surface area and well-controlled hierarchical porosity. The process allows precise control of the carbonization conditions and provides high nanoscale porosity. In comparison with classical thermal carbonization, the laser process produces much higher surface areas and smaller pores. Furthermore, we investigate the carbonization performance and the morphology of polyacrylonitrile nanofibers compounded with graphene nanoplatelet fillers...
October 17, 2016: ACS Applied Materials & Interfaces
R A Chemtob, T G Eskesen, H Moeller-Soerensen, A Perner, H B Ravn
BACKGROUND: Adequate tissue oxygenation is necessary to maintain organ function. Low venous oxygen saturation may reflect impaired tissue oxygenation, and may be used as a predictive tool and a therapeutic target to improve the care of critically ill patients. We therefore conducted a systematic review of the existing literature reflecting these aspects. METHODS: We searched electronic databases in January 2016 for relevant studies on venous oxygen saturation for treatment guidance and patient outcome...
November 2016: Acta Anaesthesiologica Scandinavica
Stefan Huber, Hans-Christoph Nuerk, Klaus Willmes, Korbinian Moeller
Different models have been proposed for the processing of multisymbol numbers like two- and three-digit numbers but also for negative numbers and decimals. However, these multisymbol numbers are assembled from the same set of Arabic digits and comply with the place-value structure of the Arabic number system. Considering these shared properties, we suggest that the processing of multisymbol numbers can be described in one general model framework. Accordingly, we first developed a computational model framework realizing componential representations of multisymbol numbers and evaluated its validity by simulating standard empirical effects of number magnitude comparison...
September 12, 2016: Psychological Review
Muhammad A Parvaz, Scott J Moeller, Rita Z Goldstein
Importance: A common trigger for relapse in drug addiction is the experience of craving via exposure to cues previously associated with drug use. Preclinical studies have consistently demonstrated incubation of cue-induced drug-seeking during the initial phase of abstinence, followed by a decline over time. In humans, the incubation effect has been shown for alcohol, nicotine, and methamphetamine addictions, but not for heroin or cocaine addiction. Understanding the trajectory of cue-induced craving during abstinence in humans is of importance for addiction medicine...
September 7, 2016: JAMA Psychiatry
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