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https://www.readbyqxmd.com/read/28802178/cardiac-arrest-due-to-ventricular-fibrillation-in-a-23-year-old-woman-with-broken-heart-syndrome
#1
Marco Giuseppe Del Buono, Michael P O'Quinn, Paulo Garcia, Enrique Gerszten, Charlotte Roberts, F Gerald Moeller, Antonio Abbate
Broken heart syndrome, also known as takotsubo cardiomyopathy, is a syndrome characterized by a transient regional systolic dysfunction of the left ventricle associated to a psychological stress. We herein describe a case of a 23-year-old female habitual marijuana user who was resuscitated after cardiac arrest and then diagnosed with midventricular stress cardiomyopathy complicated by subendocardial hemorrhage. We discuss this unique pathological finding, the incidence of arrhythmias in this syndrome, and the possible relation with chronic cannabis and tobacco use...
June 30, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28796599/reversing-adp-ribosylation
#2
Giuliana Katharina Moeller, Gyula Timinszky
The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
August 10, 2017: ELife
https://www.readbyqxmd.com/read/28792218/insights-into-the-mechanism-of-the-anodic-n-n-bond-formation-by-dehydrogenative-coupling
#3
Tile Gieshoff, Anton Kehl, Dieter Schollmeyer, Kevin D Moeller, Siegfried R R Waldvogel
The electrochemical synthesis of pyrazolidine-3,5-diones and benzoxazoles by N-N bond formation and C,O linkage respectively represents an easy access to medicinally relevant structures. Electrochemistry as key technology ensures a safe and sustainable approach. We gained insights in the mechanism of these reactions by combining cyclovoltammet-ric and synthetic studies. The electron transfer behavior of anilides and dianilides was studied and led to the following conclusion: The N-N bond formation involves a diradical as intermediate, whereas the benzoxazole formation is based on a cationic mechanism...
August 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28791499/long-term-peripheral-neuropathy-symptoms-in-breast-cancer-survivors
#4
Moaath Mustafa Ali, Machelle Moeller, Lisa Rybicki, Halle C F Moore
PURPOSE: Peripheral neuropathy (PN) is a common and distressing complication from chemotherapy. Symptoms often, but not always, improve with time. The prevalence of long-term PN symptoms in breast cancer survivors is not well known. We sought to explore PN symptoms and associated risk factors among breast cancer survivors at least 2 years out from diagnosis. METHODS: We performed a cross-sectional retrospective study investigating the prevalence of patient-reported numbness, tingling, and anesthesia symptoms as a surrogate for PN in breast cancer survivors...
August 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28778123/commentary-on-stewart-et-al-2017-stimulants-and-marijuana-the-potential-value-in-studying-substance-co-use
#5
Rachel A Rabin, Scott J Moeller
No abstract text is available yet for this article.
September 2017: Addiction
https://www.readbyqxmd.com/read/28765679/placement-instability-among-young-people-removed-from-their-original-family-and-the-likely-mental-health-implications
#6
Simon Rice, Sue Cotton, Kristen Moeller-Saxone, Cathrine Mihalopoulos, Anne Magnus, Carol Harvey, Cathy Humphreys, Stephen Halperin, Angela Scheppokat, Patrick McGorry, Helen Herrman
BACKGROUND: Young people in out-of-home care are more likely to experience poorer mental and physical health outcomes related to their peers. Stable care environments are essential for ameliorating impacts of disruptive early childhood experiences, including exposure to psychological trauma, abuse and neglect. At present there are very few high quality data regarding the placement stability history of young people in out-of-home care in Australia or other countries. OBJECTIVES: To undertake the first systematic census of background, care type and placement stability characteristics of young people living in the out-of-home care sector in Australia...
April 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28759996/real-time-elucidation-of-catalytic-pathways-in-co-hydrogenation-on-ru
#7
J LaRue, O Krejčí, L Yu, M Beye, M L Ng, H Öberg, H Xin, G Mercurio, S Moeller, J J Turner, D Nordlund, R Coffee, M P Minitti, W Wurth, L G M Pettersson, H Öström, A Nilsson, F Abild-Pedersen, H Ogasawara
The direct elucidation of the reaction pathways in heterogeneous catalysis has been challenging due to the short-lived nature of reaction intermediates. Here, we directly measured on ultrafast time scales the initial hydrogenation steps of adsorbed CO on a Ru catalyst surface, which is known as the bottleneck reaction in syngas and CO2 reforming processes. We initiated the hydrogenation of CO with an ultrafast laser temperature jump and probed transient changes in the electronic structure using real-time X-ray spectroscopy...
August 3, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28759231/discovery-of-novel-and-highly-selective-inhibitors-of-calpain-for-the-treatment-of-alzheimer%C3%A2-s-disease-2-3-phenyl-1h-pyrazol-1-yl-nicotinamides
#8
Andreas Kling, Katja Jantos, Helmut Mack, Wilfried Hornberger, Karla Drescher, Volker Nimmrich, Ana Relo, Karsten Wicke, Charles W Hutchins, Yanbin Lao, Kennan C Marsh, Achim Moeller
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer´s Disease (AD). Herein we describe our efforts leading to the identification of ketoamide-based 2-(3-phenyl-1H-pyrazol-1-yl)nicotinamides as potent and reversible inhibitors of calpain with high selectivity versus related cysteine protease cathepsins, other proteases and receptors. Broad efficacy in a set of preclinical models relevant to AD suggests that inhibition of calpain represents an attractive approach with potential benefit for the treatment of AD...
July 31, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28758968/middle-cerebral-artery-stroke-as-amusement-park-injury-case-report-and-review-of-the-literature
#9
Abby Baumgartle, Laura Wolfe, Vinay Puri, Karen Moeller, Salvatore Bertolone, Ashok Raj
Strokes as amusement park injuries are rare, but have been reported in the literature. Only about 20 cases of cerebrovascular accidents after amusement park visits have been described. We report a healthy 12-year-old boy who presented with facial droop, slurred speech, and inability to use his right arm after riding roller coasters at a local amusement park. He was evaluated and found to have a left middle cerebral artery (MCA) infarction. The patient was treated with anticoagulants and has recovered with no major residual symptoms...
July 31, 2017: Children
https://www.readbyqxmd.com/read/28756872/retinoic-acid-improves-nephrotoxic-serum-induced-glomerulonephritis-through-activation-of-podocyte-retinoic-acid-receptor-%C3%AE
#10
Yan Dai, Anqun Chen, Ruijie Liu, Leyi Gu, Shuchita Sharma, Weijing Cai, Fadi Salem, David J Salant, Jeffrey W Pippin, Stuart J Shankland, Marcus J Moeller, Norbert B Ghyselinck, Xiaquiang Ding, Peter Y Chuang, Kyung Lee, John Cijiang He
Proliferation of glomerular epithelial cells, including podocytes, is a key histologic feature of crescentic glomerulonephritis. We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating RA receptor-α (RARα) in a murine model of HIV-associated nephropathy. Here, we examined whether RA would similarly protect podocytes against nephrotoxic serum-induced crescentic glomerulonephritis and whether this effect was mediated by podocyte RARα. RA treatment markedly improved renal function and reduced the number of crescentic lesions in nephritic wild-type mice, while this protection was largely lost in mice with podocyte-specific ablation of Rara (Pod-Rara knockout)...
July 27, 2017: Kidney International
https://www.readbyqxmd.com/read/28752283/dissociation-of-binding-and-learning-processes
#11
Birte Moeller, Christian Frings
A single encounter of a stimulus together with a response can result in a short-lived association between the stimulus and the response [sometimes called an event file, see Hommel, Müsseler, Aschersleben, & Prinz, (2001) Behavioral and Brain Sciences, 24, 910-926]. The repetition of stimulus-response pairings typically results in longer lasting learning effects indicating stimulus-response associations (e.g., Logan & Etherton, (1994) Journal of Experimental Psychology: Learning, Memory, and Cognition, 20, 1022-1050]...
July 27, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28737531/potential-causes-of-elevated-ree-following-high-intensity-exercise
#12
Gary R Hunter, Douglas R Moellering, Stephen J Carter, Barbara A Gower, Marcas M Bamman, Lyndsey M Hornbuckle, Eric P Plaisance, Gordon Fisher
INTRODUCTION: Resting energy expenditure (REE) increases following intense exercise; however, little is known concerning mechanisms. PURPOSE: Determine effects of a single bout of moderate-intensity continuous aerobic exercise (MIC), or high intensity interval exercise (HII) on REE under energy balance conditions. METHODS: Thirty-three untrained premenopausal women were evaluated at baseline, after 8-16 weeks of training, 22 hours following either MIC (50% peak VO2) or HII (84% peak VO2)...
July 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28735359/binding-abstract-concepts
#13
Tarini Singh, Christian Frings, Birte Moeller
Binding theories assume that a stimulus and the response made to it are bound together in an event file (Hommel et al., Behav Brain Sci 24(05):849-937, 2001). Such bindings can occur even after single encounters. If the stimulus or parts of its features are repeated within the time frame in which the event file is still intact, the previously integrated response is retrieved. Stimulus-response binding can exist at a perceptual, conceptual or a response selection level (Henson et al., Trends Cogn Sci 18(7):376-384, 2014)...
July 22, 2017: Psychological Research
https://www.readbyqxmd.com/read/28726057/macrophage-migration-inhibitory-factor-mif-modulates-trophic-signaling-through-interaction-with-serine-protease-htra1
#14
Åsa Fex Svenningsen, Svenja Löring, Anna Lahn Sørensen, Ha Uyen Buu Huynh, Simone Hjæresen, Nellie Martin, Jesper Bonnet Moeller, Maria Louise Elkjær, Uffe Holmskov, Zsolt Illes, Malin Andersson, Solveig Beck Nielsen, Eirikur Benedikz
Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is implicated in some of the same diseases as MIF...
July 19, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28721664/reciprocal-influence-of-hmscs-hacat-cultivated-on-electrospun-scaffolds
#15
Sirsendu Bhowmick, Sandra Rother, Heike Zimmermann, Poh S Lee, Stephanie Moeller, Matthias Schnabelrauch, Veena Koul, Dieter Scharnweber
Here, we investigated the synergistic effect of electrospun nanofibrous scaffolds made of gelatin /sulfated hyaluronan (sHA) or native hyaluronan (HA)/chondroitin sulfate (CS) and, keratinocytes (HaCaT)-human mesenchymal stem cells (hMSCs) contact co-culture on epithelial differentiation of hMSCs. The hMSCs were co-cultured in contact with HaCaT cells for 5 days on electrospun scaffold. Results show that electrospun scaffolds containing sulfated glycosaminoglycans (GAGs) stimulate epithelial differentiation in terms of various protein expression markers (keratin 14, ΔNp63α and Pan-cytokeratin) and gene expression of several dermal proteins (keratin 14, ΔNp63α)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28720442/impact-of-baseline-covariates-on-the-immunogenicity-of-the-9-valent-hpv-vaccine-a-combined-analysis-of-five-phase-iii-clinical-trials
#16
Lone K Petersen, Jaime Restrepo, Edson D Moreira, Ole-Erik Iversen, Punnee Pitisuttithum, Pierre Van Damme, Elmar A Joura, Sven-Erik Olsson, Daron Ferris, Stan Block, Anna R Giuliano, Xavier Bosch, Sophie Pils, Jack Cuzick, Suzanne M Garland, Warner Huh, Susanne K Kjaer, Oliver M Bautista, Donna Hyatt, Roger Maansson, Erin Moeller, Hong Qi, Christine Roberts, Alain Luxembourg
BACKGROUND: The immunogenicity profile of the 9-valent HPV (9vHPV) vaccine was evaluated across five phase III clinical studies conducted in girls and boys 9-15 years of age and young women 16-26 years of age. The effect of baseline characteristics of subjects on vaccine-induced HPV antibody responses was assessed. METHODS: Immunogenicity data from 11,304 subjects who received ≥1 dose of 9vHPV vaccine in five Phase III studies were analyzed. Vaccine was administered as a 3-dose regimen...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28719981/the-mental-representation-of-the-human-gait-in-patients-with-severe-knee-osteoarthrosis-a-clinical-study-to-aid-understanding-of-impairment-and-disability
#17
Robert Jacksteit, Anett Mau-Moeller, Martin Behrens, Rainer Bader, Wolfram Mittelmeier, Ralf Skripitz, Tino Stöckel
OBJECTIVE: Objectives were (1) to explore differences in gait-specific long-term memory structures and gait performance between knee osteoarthrosis patients and healthy subjects and (2) to identify the extent to which the gait-specific mental representation is associated with gait performance. DESIGN: Cross-sectional study. SUBJECTS: In total, 18 knee osteoarthrosis patients and 18 control subjects. METHODS: Spatio-temporal (gait speed, step length) and temporophasic (stance time, swing time, single support time, total double support time) gait parameters and gait variability were measured with an electronic walkway (OptoGait)...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28716479/lower-exhaled-nitric-oxide-in-infants-with-cystic-fibrosis-compared-to-healthy-controls
#18
Insa Korten, Margot Liechti, Florian Singer, Gaudenz Hafen, Isabelle Rochat, Pinelopi Anagnostopoulou, Dominik Müller-Suter, Jakob Usemann, Alexander Moeller, Urs Frey, Philipp Latzin, Carmen Casaulta
Exhaled nitric oxide (FENO) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FENO is decreased. To understand if reduced FENO is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FENO in 34 infants with CF prior to clinical symptoms and in 68 healthy controls. FENO was lower in CF compared to controls (p=0.0006) and the effect was more pronounced in CF infants without residual CFTR function (p<0...
July 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28710891/preferential-plastid-retention-by-the-acquired-phototroph-mesodinium-chamaeleon
#19
Holly V Moeller, Matthew D Johnson
The ciliate genus Mesodinium contains species that rely to varying degrees on photosynthetic machinery stolen from cryptophyte algal prey. Prey specificity appears to scales inversely with this reliance: The predominantly phototrophic M. major/rubrum species complex exhibits high prey specificity, while the heterotrophic lineages M. pulex and pupula are generalists. Here, we test the hypothesis that the recently described mixotroph M. chamaeleon, which is phylogenetically intermediate between M. major/rubrum and M...
July 15, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28692800/n-6-formyllysine-as-a-biomarker-of-formaldehyde-exposure-formation-and-loss-of-n-6-formyllysine-in-nasal-epithelium-in-long-term-low-dose-inhalation-studies-in-rats
#20
Bahar Edrissi, Koli Taghizadeh, Benjamin C Moeller, Rui Yu, Dean Kracko, Melanie Doyle-Eisele, James A Swenberg, Peter C Dedon
Exposure to both endogenous and exogenous formaldehyde has been established to be carcinogenic, likely by virtue of forming nucleic acid and proteins adducts such as N(6)-formyllysine. To better assess N(6)-formyllysine as a biomarker of formaldehyde exposure, we studied accumulation of N(6)-formyllysine adducts in tissues of rats exposed by inhalation to 2 ppm [(13)C(2)H2]-formaldehyde for 7, 14, 21, and 28 days (6 h/day) and investigated adduct loss over a 7-day postexposure period using liquid chromatography-coupled tandem mass spectrometry...
July 27, 2017: Chemical Research in Toxicology
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