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The first observation of top quark production in proton-nucleus collisions is reported using proton-lead data collected by the CMS experiment at the CERN LHC at a nucleon-nucleon center-of-mass energy of sqrt[s_{NN}]=8.16 TeV. The measurement is performed using events with exactly one isolated electron or muon candidate and at least four jets. The data sample corresponds to an integrated luminosity of 174 nb^{-1}. The significance of the tt[over ¯] signal against the background-only hypothesis is above 5 standard deviations...

*December 15, 2017: Physical Review Letters*