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https://www.readbyqxmd.com/read/27898938/effects-of-varying-floor-space-on-aggressive-behavior-and-cortisol-concentrations-in-group-housed-sows
#1
P H Hemsworth, R S Morrison, A J Tilbrook, K L Butler, M Rice, S J Moeller
Floor space is an important determinant of aggression and stress in group-housed sows, and the aim of the present experiment was to comprehensively examine the effects of floor space in the range of 1.45 to 2.90 m/sow from mixing until 27 d after insemination on aggression, stress, and reproduction of group-housed sows. A previous experiment on the effects of floor space indicated spatial variability across and along the research facility in both sow aggression and stress. To minimize this spatial variability within the research facility, similar-sized pens but with varying groups sizes (10-20) in 4 separate blocks of 3 contiguous pens within each of 9 time replicates (180 sows/replicate) were used to examine 6 space allowances (1...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895155/investigations-of-glucocorticoid-action-in-gn
#2
Christoph Kuppe, Claudia van Roeyen, Katja Leuchtle, Nazanin Kabgani, Michael Vogt, Marc Van Zandvoort, Bart Smeets, Jürgen Floege, Hermann-Josef Gröne, Marcus J Moeller
For several decades, glucocorticoids have been used empirically to treat rapid progressive GN. It is commonly assumed that glucocorticoids act primarily by dampening the immune response, but the mechanisms remain incompletely understood. In this study, we inactivated the glucocorticoid receptor (GR) specifically in kidney epithelial cells using Pax8-Cre/GR(fl/fl) mice. Pax8-Cre/GR(fl/fl) mice did not exhibit an overt spontaneous phenotype. In mice treated with nephrotoxic serum to induce crescentic nephritis (rapidly progressive GN), this genetic inactivation of the GR in kidney epithelial cells exerted renal benefits, including inhibition of albuminuria and cellular crescent formation, similar to the renal benefits observed with high-dose prednisolone in control mice...
November 28, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27894889/tradeoffs-in-pushing-the-spatial-resolution-of-fmri-for-the-7t-human-connectome-project
#3
An Thanh Vu, Keith Jamison, Matthew F Glasser, Stephen M Smith, Timothy Coalson, Steen Moeller, Edward J Auerbach, Kamil Ugurbil, Essa Yacoub
Whole-brain functional magnetic resonance imaging (fMRI), in conjunction with multiband acceleration, has played an important role in mapping the functional connectivity throughout the entire brain with both high temporal and spatial resolution. Ultrahigh magnetic field strengths (7T and above) allow functional imaging with even higher functional contrast-to-noise ratios for improved spatial resolution and specificity compared to traditional field strengths (1.5T and 3T). High-resolution 7T fMRI, however, has primarily been constrained to smaller brain regions given the amount of time it takes to acquire the number of slices necessary for high resolution whole brain imaging...
November 25, 2016: NeuroImage
https://www.readbyqxmd.com/read/27847001/the-antecedents-experience-and-coping-strategies-of-driver-boredom-in-young-adult-males
#4
Fabius Steinberger, April Moeller, Ronald Schroeter
INTRODUCTION: Road crash statistics are evidence of the severe consequences resulting from human error, especially among young adult males. Drivers perform best and safest when they are adequately engaged in the driving task. Boredom and a lack of engagement in the driving task may cause risk taking and phone use. However, the antecedents to driver boredom, the subjective experience itself, as well as the coping strategies to combat boredom are not well understood. The aim of this study was to investigate these aspects...
December 2016: Journal of Safety Research
https://www.readbyqxmd.com/read/27828320/x-ray-absorption-spectroscopy-using-a-self-seeded-soft-x-ray-free-electron-laser
#5
Thomas Kroll, Jan Kern, Markus Kubin, Daniel Ratner, Sheraz Gul, Franklin D Fuller, Heike Löchel, Jacek Krzywinski, Alberto Lutman, Yuantao Ding, Georgi L Dakovski, Stefan Moeller, Joshua J Turner, Roberto Alonso-Mori, Dennis L Nordlund, Jens Rehanek, Christian Weniger, Alexander Firsov, Maria Brzhezinskaya, Ruchira Chatterjee, Benedikt Lassalle-Kaiser, Raymond G Sierra, Hartawan Laksmono, Ethan Hill, Andrew Borovik, Alexei Erko, Alexander Föhlisch, Rolf Mitzner, Vittal K Yachandra, Junko Yano, Philippe Wernet, Uwe Bergmann
X-ray free electron lasers (XFELs) enable unprecedented new ways to study the electronic structure and dynamics of transition metal systems. L-edge absorption spectroscopy is a powerful technique for such studies and the feasibility of this method at XFELs for solutions and solids has been demonstrated. However, the required x-ray bandwidth is an order of magnitude narrower than that of self-amplified spontaneous emission (SASE), and additional monochromatization is needed. Here we compare L-edge x-ray absorption spectroscopy (XAS) of a prototypical transition metal system based on monochromatizing the SASE radiation of the linac coherent light source (LCLS) with a new technique based on self-seeding of LCLS...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27816941/the-international-college-of-neuro-psychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-2-review-grading-of-the-evidence-and-a-precise-algorithm
#6
REVIEW
Konstantinos N Fountoulakis, Lakshmi Yatham, Heinz Grunze, Eduard Vieta, Allan Young, Pierre Blier, Siegfried Kasper, Hans Jurgen Moeller
BACKGROUND: The current paper includes the systematic search of the literature, the detailed presentation of the results and the grading of treatment options in terms of efficacy and tolerability/safety. MATERIAL AND METHODS: The PRISMA method was used in the search of the literature with the combination of the words 'bipolar', 'manic', 'mania', 'manic depression' and 'manic depressive' with 'randomized', and 'algorithms' with 'mania', 'manic', 'bipolar', 'manic-depressive' or 'manic depression'...
November 5, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27815414/the-international-college-of-neuropsychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-1-background-and-methods-of-the-development-of-guidelines
#7
REVIEW
Konstantinos N Fountoulakis, Allan Young, Lakshmi Yatham, Heinz Grunze, Eduard Vieta, Pierre Blier, Hans Jurgen Moeller, Siegfried Kasper
BACKGROUND: This paper includes a short description of the important clinical aspects of Bipolar Disorder with emphasis on issues that are important for the therapeutic considerations, including mixed and psychotic features, predominant polarity, and rapid cycling as well as comorbidity. METHODS: The workgroup performed a review and critical analysis of the literature concerning grading methods and methods for the development of guidelines. RESULTS: The workgroup arrived at a consensus to base the development of the guideline on randomized controlled trials and related meta-analyses alone in order to follow a strict evidence-based approach...
November 4, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27811049/phage-mediated-horizontal-gene-transfer-of-both-prophage-and-heterologous-dna-by-%C3%AF-bb-1-a-bacteriophage-of-borrelia-burgdorferi
#8
Christian H Eggers, Carlie M Gray, Alexander M Preisig, Danielle M Glenn, Jessica Pereira, Ryan W Ayers, Mohammad Alshahrani, Christopher Acabbo, Maria R Becker, Kimberly N Bruenn, Timothy Cheung, Taylor M Jendras, Aron B Shepley, John T Moeller
Horizontal gene transfer (HGT) in Borrelia burgdorferi, the Lyme disease agent, is likely mediated by bacteriophage. Studies of the B. burgdorferi phage, ϕBB-1, and its role in HGT have been hindered by the lack of an assay for readily characterizing phage-mediated DNA movement (transduction). Here we describe an in vitro assay in which a clone of B. burgdorferi strain CA-11.2A encoding kanamycin resistance on a ϕBB-1 prophage is co-cultured with different clones encoding gentamicin resistance on a shuttle vector; transduction is monitored by enumerating colonies selected in the presence of both kanamycin and gentamicin...
November 2, 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27792406/developmental-programming-insulin-sensitizer-prevents-the-gnrh-stimulated-lh-hypersecretion-in-a-sheep-model-of-pcos
#9
Rodolfo C Cardoso, Ashleigh Burns, Jacob Moeller, Donal C Skinner, Vasantha Padmanabhan
Prenatal testosterone (T) treatment recapitulates the reproductive and metabolic phenotypes of polycystic ovary syndrome in female sheep. At the neuroendocrine level, prenatal T treatment results in disrupted steroid feedback on gonadotropin release, increased pituitary sensitivity to GnRH, and subsequent LH hypersecretion. Because prenatal T-treated sheep manifest functional hyperandrogenism and hyperinsulinemia, gonadal steroids and/or insulin may play a role in programming and/or maintaining these neuroendocrine defects...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27777930/characterization-of-aqps-in-mouse-rat-and-human-colon-and-their-selective-regulation-by-bile-acids
#10
Jonathan Yde, Stephen Keely, Qi Wu, Johan F Borg, Natalia Lajczak, Aoife O'Dwyer, Peter Dalsgaard, Robert A Fenton, Hanne B Moeller
In normal individuals, the epithelium of the colon absorbs 1.5-2 l of water a day to generate dehydrated feces. However, in the condition of bile acid malabsorption (BAM), an excess of bile acids in the colon results in diarrhea. Several studies have attempted to address the mechanisms contributing to BAM induced by various bile acids. However, none have addressed a potential dysregulation of aquaporin (AQP) water channels, which are responsible for the majority of transcellular water transport in epithelial cells, as a contributing factor to the onset of diarrhea and the pathogenesis of BAM...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27776001/central-factors-contribute-to-knee-extensor-strength-loss-after-2000-m-rowing-in-elite-male-and-female-rowers
#11
Florian Husmann, Martin Gube, Sabine Felser, Matthias Weippert, Anett Mau-Moeller, Sven Bruhn, Martin Behrens
PURPOSE: Despite growing interest in task-dependent alterations of central and peripheral fatigue following endurance exercise, little is known about the impact of rowing on quadriceps muscle fatigue. This study aimed to investigate central and peripheral mechanisms of fatigue following a 2000-m rowing time-trial. METHODS: Eight competitive rowers (4 males, 4 females, 20 ± 4 years) performed a 2000-m time-trial on an indoor rower and a control condition (sitting)...
October 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27766092/identification-of-differentially-expressed-genes-during-bacillus-subtilis-spore-outgrowth-in-high-salinity-environments-using-rna-sequencing
#12
Katja Nagler, Antonina O Krawczyk, Anne De Jong, Kazimierz Madela, Tamara Hoffmann, Michael Laue, Oscar P Kuipers, Erhard Bremer, Ralf Moeller
In its natural habitat, the soil bacterium Bacillus subtilis often has to cope with fluctuating osmolality and nutrient availability. Upon nutrient depletion it can form dormant spores, which can revive to form vegetative cells when nutrients become available again. While the effects of salt stress on spore germination have been analyzed previously, detailed knowledge on the salt stress response during the subsequent outgrowth phase is lacking. In this study, we investigated the changes in gene expression during B...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27750113/laboratory-impulsivity-and-depression-in-blast-exposed-military-personnel-with-post-concussion-syndrome
#13
James M Bjork, Thomas K Burroughs, Laura M Franke, Treven C Pickett, Sade E Johns, F Gerard Moeller, William C Walker
In military populations, traumatic brain injury (TBI) also holds potential to increase impulsivity and impair mood regulation due to blast injury effects on ventral frontal cortex - to put military personnel at risk for suicide or substance abuse. We assessed a linkage between depression and impaired behavioral inhibition in 117 blast-exposed service members (SM) and veterans with post-concussion syndrome (PCS), where PCS was defined using a Rivermead Postconcussive Symptom Questionnaire (RPQ) modified to clarify whether each symptom worsened compared to pre-blast...
October 7, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27748392/minimal-change-disease-and-idiopathic-fsgs-manifestations-of-the-same-disease
#14
REVIEW
Rutger J Maas, Jeroen K Deegens, Bart Smeets, Marcus J Moeller, Jack F Wetzels
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the key histological findings in patients with idiopathic nephrotic syndrome (INS). Although MCD and idiopathic FSGS are often considered to represent separate entities based on differences in their presenting characteristics, histology and outcomes, little evidence exists for this separation. We propose that MCD and idiopathic FSGS are different manifestations of the same progressive disease. The gradual development of FSGS in patients with non-remitting or relapsing INS has been well documented...
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27739135/effects-of-intensive-and-alternative-production-systems-on-the-technological-and-quality-parameters-of-rapeseed-seed-brassica-napus-l-siska
#15
Maja Turinek, Martina Bavec, Milan Repič, Matjaž Turinek, Andreja Urbanek Krajnc, Christian Möllers, Alba Tres, Franc Bavec
BACKGROUND: Organic production is widely assumed to affect quality and nutritional parameters of arable crops. A field experiment was started in 2009 following integrated (INT), organic (ORG) and biodynamic (BD) production standards for wheat, maize and rapeseed production. With resort to standard analytical procedures and chemometrics, compositional parameters of Brassica napus L. 'Siska' seed (water, protein, oil and glucosinolate content) by non-destructive near-infrared spectroscopy (NIRS), and fatty acid composition determined by gas chromatography, were assessed...
October 14, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27729852/reward-vs-retaliation-the-role-of-the-mesocorticolimbic-salience-network-in-human-reactive-aggression
#16
Gabriela Gan, Rebecca N Preston-Campbell, Scott J Moeller, Joel L Steinberg, Scott D Lane, Thomas Maloney, Muhammad A Parvaz, Rita Z Goldstein, Nelly Alia-Klein
The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27696251/targeted-next-generation-sequencing-for-tp53-ras-braf-alk-and-nf1-mutations-in-anaplastic-thyroid-cancer
#17
Soeren Latteyer, Vera Tiedje, Katharina König, Saskia Ting, Lukas C Heukamp, Lydia Meder, Kurt Werner Schmid, Dagmar Führer, Lars Christian Moeller
Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a median survival of 4-6 months. Identification of mutations contributing to aberrant activation of signaling cascades in ATC may provide novel opportunities for targeted therapy. Thirty-nine ATC samples were studied by next-generation sequencing (NGS) with an established gene panel. High quality readout was obtained in 30/39 ATC. Twenty-eight ATC harbored a mutation in at least one of the studied genes: TP53 (18/30), NF1 (11/30), ALK (6/30), NRAS (4/30), ATRX (3/30), BRAF (2/30), HRAS (2/30), KRAS (1/30)...
October 1, 2016: Endocrine
https://www.readbyqxmd.com/read/27695718/meeting-the-primary-care-needs-%C3%A2-of-young-people-in-residential-care
#18
Kristen Moeller-Saxone, Louise McCutcheon, Stephen Halperin, Helen Herrman, Andrew M Chanen
BACKGROUND: Young people in out-of-home care, especially those with a history of multiple placements, typically have numerous and complex health needs, and worse health outcomes than their peers who grow up within a family of origin. A significant proportion of this can be attributed to policy failures and poor interagency communication. OBJECTIVE: The objective of this article is to describe the factors that contribute to the health needs of young people in out-of-home care and the tools available to support general practitioners (GPs) to provide care...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27679486/identification-of-small-molecule-inhibitors-of-human-cytochrome-c-oxidase-that-target-chemoresistant-glioma-cells
#19
Claudia R Oliva, Tahireh Markert, Larry J Ross, E Lucile White, Lynn Rasmussen, Wei Zhang, Maaike Everts, Douglas R Moellering, Shannon M Bailey, Mark J Suto, Corinne E Griguer
The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic to oxidative phosphorylation (OXPHOS) metabolism and has been associated with increased self-renewal characteristics in gliomas. Increased CcO activity in tumors has been associated with tumor progression after chemotherapy failure, and patients with primary glioblastoma multiforme and high tumor CcO activity have worse clinical outcomes than those with low tumor CcO activity...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27677983/the-international-college-of-neuropsychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-4-unmet-needs-in-the-treatment-of-bipolar-disorder-and-recommendations-for-future-research
#20
Konstantinos N Fountoulakis, Eduard Vieta, Allan Young, Lakshmi Yatham, Heinz Grunze, Pierre Blier, Hans Jurgen Moeller, Siegfried Kasper
BACKGROUND: The current fourth paper on the International College of Neuropsychopharmacology guidelines for the treatment of bipolar disorder reports on the unmet needs that became apparent after an extensive review of the literature and also serves as a conclusion to the project of the International College of Neuropsychopharmacology workgroup. MATERIALS AND METHODS: The systematic review of the literature that was performed to develop the International College of Neuropsychopharmacology guidelines for bipolar disorder identified and classified a number of potential shortcomings...
October 11, 2016: International Journal of Neuropsychopharmacology
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