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https://www.readbyqxmd.com/read/28926139/the-synonymous-nucleotide-substitution-rhd-1056c-g-alters-mrna-splicing-associated-with-serologically-weak-d-phenotype
#1
Sejong Chun, Jae Won Yun, Geon Park, Duck Cho
BACKGROUND: D antigen is one of the most clinically significant blood group antigens. Variation of the RHD gene can cause weak D or partial D phenotypes. While most variations are missense substitutions with amino acid changes, those without are called "silent" or "synonymous" substitutions. Synonymous substitutions often have little effect on the protein, not altering the phenotype. However, effect on splicing can affect end-product protein. We report a new synonymous variation, RHD 1056C>G, that resulted in weak D phenotype, and predicted its effect with various in silico methods...
September 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28925472/the-erlangen-questionnaire-a-new-5-item-screening-tool-for-obstructive-sleep-apnea-in-a-sleep-clinic-population-a-prospective-double-blinded-study
#2
M Traxdorf, K Tziridis, C Scherl, H Iro, J Haferkamp
OBJECTIVE: The aim of this study was to develop and validate a simplified screening tool for identifying obstructive sleep apnea (OSA) in a sleep clinic population. PATIENTS AND METHODS: A total of 160 patients from a sleep clinic population was enrolled in the prospective, double-blinded study. OSA was defined by using diagnostic criteria of the ICSD-3 after overnight polysomnography (n=96) or polygraphy (n=64). The first 60 patients filled out a multi-item questionnaire and formed the development group...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#3
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28918571/the-effect-of-communication-skills-training-on-patient-pharmacist-communication-in-pharmacy-education-a-meta-analysis
#4
REVIEW
Hye Kyung Jin, Jae Hee Choi, Ji Eun Kang, Sandy Jeong Rhie
Communication skills in pharmacy education and practice are increasingly regarded as a crucial component. However, thus far, estimating of the overall communication skills training (CST) effects in a variety of outcomes is lacking. The aim of this study was to synthesize the effects of CST in pharmacy education by performing a meta-analysis of CST studies. We searched MEDLINE, EMBASE, ERIC, CINAHL, PsycINFO, Cochrane Library, Web of Science, Communication and Mass Media Complete (CMMC), key journals, and bibliographic databases...
September 16, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28918361/daytime-sleepiness-and-related-factors-in-nursing-students
#5
Gökçe Demir
BACKGROUND: Evaluation of the frequency and causes of daytime sleepiness in nursing students because it is an important factor in improving the health status of the students, controlling sleep problems, improving students' academic achievements, and maintaining a healthy lifestyle. AIM: The aim of this study was to determine the prevalence of daytime sleepiness in nursing students and the factors associated with it. DESIGN: A cross-sectional research design was used in this study...
August 26, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28917684/role-of-low-endothelial-shear-stress-and-plaque-characteristics-in-the-prediction-of-nonculprit-major-adverse-cardiac-events-the-prospect-study
#6
Peter H Stone, Akiko Maehara, Ahmet Umit Coskun, Charles C Maynard, Marina Zaromitydou, Gerasimos Siasos, Ioannis Andreou, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Alexandra J Lansky, Gary S Mintz, Patrick W Serruys, Charles L Feldman, Gregg W Stone
OBJECTIVES: This study sought to determine whether low endothelial shear stress (ESS) adds independent prognostication for future major adverse cardiac events (MACE) in coronary lesions in patients with high-risk acute coronary syndrome (ACS) from the United States and Europe. BACKGROUND: Low ESS is a proinflammatory, proatherogenic stimulus associated with coronary plaque development, progression, and destabilization in human-like animal models and in humans. Previous natural history studies including baseline ESS characterization investigated low-risk patients...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28910667/properties-of-afterdischarges-from-electrical-stimulation-in-patients-with-epilepsy
#7
Chang Liu, Tao Yu, Zhi-Wei Ren, Cui-Ping Xu, Xue-Yuan Wang, Liang Qiao, Duan-Yu Ni, Guo-Jun Zhang, Yong-Jie Li
OBJECTIVE: To investigate the properties of afterdischarges (ADs) from intracerebral electrical stimulation (ES) in patients with epilepsy who underwent stereotactic electroencephalography (SEEG) and determine the relationship between epileptogenic zone (EZ) or irritative zone (IZ) and ADs. METHODS: We retrospectively analyzed 10 patients with intractable epilepsy who underwent SEEG. ESs were delivered following the given parameters: bipolar, biphasic, 50Hz, 0.2ms pulse duration, 0...
September 7, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28906310/endometrial-stromal-sarcoma-of-the-uterus-magnetic-resonance-imaging-findings-including-apparent-diffusion-coefficient-value-and-its-correlation-with-ki-67-expression
#8
Hai Ming Li, Jia Liu, Jin Wei Qiang, Wei Yong Gu, Guo Fu Zhang, Feng Hua Ma
OBJECTIVE: This study aimed to investigate the conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) features of endometrial stromal sarcoma (ESS) including a preliminary investigation of the correlation between the apparent diffusion coefficient (ADC) value and Ki-67 expression. METHODS: The clinical and MRI data of 15 patients with ESS confirmed by surgery and pathology were analyzed retrospectively. The conventional MR morphological features, signal intensity on DWI, ADC value (n = 14), and clinicopathological marker Ki-67 (n = 13) were evaluated...
September 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28902931/binge-drinking-a-pattern-associated-with-a-risk-of-problems-of-alcohol-use-among-university-students
#9
André Bedendo, André Luiz Monezi Andrade, Emérita Sátiro Opaleye, Ana Regina Noto
Objective: to evaluate problems associated with alcohol use among university students who reported binge drinking in comparison to students who consumed alcohol without binging. Method: a cross-sectional study among university students (N=2,408) who accessed the website about alcohol use. Logistic and linear regression models were included in the statistical analyzes. Results: alcohol use in the last three months was reported by 89.2% of university students; 51...
September 12, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28902230/chronic-kidney-disease-and-metabolic-syndrome-as-risk-factors-for-cardiovascular-disease-in-a-primary-care-program
#10
Suzana Greffin, Mauro Barros André, Jorge Paulo Strogoff de Matos, Hye Chung Kang, Antonio José Lagoeiro Jorge, Maria Luiza Garcia Rosa, Jocemir Ronaldo Lugon
Introduction: Cardiovascular disease (CVD) is especially prevalent in patients with chronic kidney disease (CKD). Objective: To evaluate the role of CKD and metabolic syndrome (MS), which is a cluster of risk factors for CVD, as predictors of CVD. Methods: Observational, cross-sectional study with a random sample aged 45 or more years extracted from the population assisted by the primary care program in Niterói city in the state of Rio de Janeiro, Brazil...
August 28, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28895721/eukaryotic-ribosomal-expansion-segments-as-antimicrobial-targets
#11
Lizzette M Gómez Ramos, Natalya N Degtyareva, Nicholas A Kovacs, Stefany Y Holguin, Liuwei Jiang, Anton S Petrov, Marcin Biesiada, Michael Y Hu, Katarzyna J Purzycka, Dev Priya Arya, Loren Dean Williams
Diversity in eukaryotic rRNA structure and function offers possibilities of novel therapeutic targets. Unlike ribosomes of prokaryotes, eukaryotic ribosomes contain species-specific rRNA expansion segments (ESs) with idiosyncratic structures and functions that are essential and specific to some organisms. Here we investigate expansion segment 7 (ES7), one of the largest and most variable expansions of the eukaryotic ribosome. We hypothesize that ES7 of the pathogenic fungi Candida albicans (ES7CA) could be a prototypic drug target...
September 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28894833/ethmoidectomy-combined-with-superior-meatus-enlargement-increases-olfactory-airflow
#12
Hironobu Nishijima, Kenji Kondo, Tsutomu Nomura, Tatsuya Yamasoba
OBJECTIVES: The relationship between a particular surgical technique in endoscopic sinus surgery (ESS) and airflow changes in the post-operative olfactory region has not been assessed. The present study aimed to compare olfactory airflow after ESS between conventional ethmoidectomy and ethmoidectomy with superior meatus enlargement, using virtual ESS and computational fluid dynamics (CFD) analysis. STUDY DESIGN: Prospective computational study. MATERIALS AND METHODS: Nasal computed tomography images of four adult subjects were used to generate models of the nasal airway...
August 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894830/a-study-of-otolaryngology-resident-quality-of-life-and-sleepiness
#13
Laura R Garcia-Rodriguez, Dominique L Sanchez, Alvin B Ko, Amy M Williams, Ed Peterson, Kathleen L Yaremchuk
OBJECTIVES: This study aimed to determine otolaryngology residents' quality of life and sleepiness. METHODS: An electronic survey was distributed to otolaryngology residents in the United States in October 2014 and May 2015. The survey included questions from the Physician Well-Being Index (PWBI) and Epworth Sleepiness Scale (ESS). Data were analyzed using standard descriptive and frequency analyses, Spearman correlations, and Student's t-test. RESULTS: The 196 respondents (13% response rate) had a mean age of 29...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28893614/the-impact-of-electronic-healthcare-associated-infection-surveillance-software-on-infection-prevention-resources-a-systematic-review-of-the-literature
#14
Philip L Russo, Ramon Z Shaban, Deborough MacBeth, Abigail Carter, Brett G Mitchell
BACKGROUND: Surveillance of healthcare-associated infections is fundamental for infection prevention. The methods and practices for surveillance have evolved as technology becomes more advanced. The availability of electronic surveillance software (ESS) has increased, and yet adoption of ESS is slow. It is argued that ESS deliver savings through automation, particularly in terms of human resourcing and infection prevention (IP) staff time. AIM: This paper describes the findings of a systematic review on the impact of ESS on IP resources...
September 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28889259/an-ultrasensitive-and-selective-electrochemical-sensor-for-determination-of-estrone-3-sulfate-sodium-salt-based-on-molecularly-imprinted-polymer-modified-carbon-paste-electrode
#15
Han Song, Yuli Wang, Lu Zhang, Liping Tian, Jun Luo, Na Zhao, Yajie Han, Feilang Zhao, Xue Ying, Yingchun Li
A highly sensitive and selective electrochemical sensor based on carbon paste electrode (CPE) modified with molecularly imprinted polymers (MIPs) has been developed for the determination of estrone 3-sulfate sodium salt (ESS). MIPs were prepared in polar medium via bulk polymerization and characterized by scanning electron microscopy and infrared spectroscopy. Cyclic voltammetry was performed to the study preparation process and binding behavior of the MIP-modified CPE (MIP/CPE) toward ESS. The conditions for preparing MIPs and MIP/CPE as well as ESS detection were optimized...
September 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28884322/assessment-of-sleepiness-fatigue-and-depression-among-gulf-cooperation-council-commercial-airline-pilots
#16
Tareq M Aljurf, Awad H Olaish, Ahmed S BaHammam
PURPOSE: No studies have assessed the prevalence of fatigue, depression, sleepiness, and the risk of obstructive sleep apnea (OSA) among commercial airlines pilots in the Gulf Cooperation Council (GCC). METHODS: This was a quantitative cross-sectional study conducted among pilots who were on active duty and had flown during the past 6 months for one of three commercial airline companies. We included participants with age between 20 and 65 years. Data were collected using a predesigned electronic questionnaire composed of questions related to demographic information in addition to the Fatigue Severity Scale (FSS), the Berlin Questionnaire, the Epworth Sleepiness Scale (ESS), and the Hospital Anxiety and Depression Scale (HADS)...
September 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28883601/how-prepared-are-foundation-dentists-in-england-and-wales-for-independent-general-dental-practice
#17
M Ray, A Milston, P Doherty, S Crean
Introduction The Graduate Assessment of Preparedness for Practice (GAPP) questionnaire has been shown to be valid and reliable in assessing the preparedness of foundation dentists (FDs) for independent general dental practice (GDP). In this study it is used to establish preparedness at six weeks of dental foundation training (DFT) across England and Wales.Method GAPP questionnaires were sent to all FDs and ESs in England and Wales in mid-September 2012. Part 1 of the GAPP questionnaire collected the descriptive data of respondents...
September 8, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28876411/binge-drinking-and-illicit-drug-use-among-adolescent-students
#18
Jakelline Cipriano Dos Santos Raposo, Ana Carolina de Queiroz Costa, Paula Andréa de Melo Valença, Patrícia Maria Zarzar, Alcides da Silva Diniz, Viviane Colares, Carolina da Franca
OBJECTIVE: To estimate the prevalence of illicit drug use and its association with binge drinking and sociodemographic factors among adolescent students. METHODS: This is a cross-sectional study with probabilistic conglomerate sampling, involving 1,154 students, aged 13 to 19 years old, from the public school system, in the city of Olinda, State of Pernambuco, Brazil, carried out in 2014. We used the Youth Risk Behavior Survey questionnaire, validated for use with Brazilian adolescents...
September 4, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28874412/isolation-of-a-membrane-protein-complex-for-type-vii-secretion-in-staphylococcus-aureus
#19
Khaled A Aly, Mark Anderson, Ryan Jay Ohr, Dominique Missiakas
The ESAT6-like secretion system (ESS) of Staphylococcus aureus promotes effector protein transport across the bacterial envelope. Genes in the ESS cluster are required for S. aureus establishment of persistent abscess lesions and the modulation of immune responses during blood stream infections. The biochemical functions of most of the ESS gene products, specifically the identity of secretion machine components, are however unknown. Earlier work demonstrated that deletion of essB, which encodes a membrane protein, abolishes S...
September 5, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28873286/the-impact-of-asthma-on-the-cost-effectiveness-of-surgery-for-chronic-rhinosinusitis-with-nasal-polyps
#20
George A Scangas, Aaron K Remenschneider, Brooke M Su, Mark G Shrime, Ralph Metson
BACKGROUND: The objective of this work was to evaluate the impact of asthma on the cost-effectiveness profile of endoscopic sinus surgery (ESS) compared to medical therapy for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: The study design consisted of a cohort-style Markov decision-tree cost utility analysis with a 35-year time horizon. Matched cohorts of CRSwNP patients with (n = 95) and without (n = 95) asthma who underwent ESS were compared with cohorts of patients from the national Medical Expenditures Survey Panel (MEPS) database who underwent medical management for chronic rhinosinusitis (CRS)...
September 5, 2017: International Forum of Allergy & Rhinology
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