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https://www.readbyqxmd.com/read/29210341/-without-this-program-women-can-lose-their-lives-migrant-women-s-experiences-with-the-safe-abortion-referral-programme-in-chiang-mai-thailand
#1
Ellen Tousaw, Ra Khin La, Grady Arnott, Orawee Chinthakanan, Angel M Foster
For displaced and migrant women in northern Thailand, access to health care is often limited, unwanted pregnancy is common, and unsafe abortion is a major contributor to maternal death and disability. Based on a pilot project and situational analysis research, in 2015 a multinational team introduced the Safe Abortion Referral Programme (SARP) in Chiang Mai, Thailand, to reduce the socio-linguistic, economic, documentation, and transportation barriers women from Burma face in accessing safe and legal abortion care in Thailand...
December 6, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29201668/efficacy-of-intrauterine-injection-of-granulocyte-colony-stimulating-factor-g-csf-on-treatment-of-unexplained-recurrent-miscarriage-a-pilot-rct-study
#2
Simin Zafardoust, Mohammad Mehdi Akhondi, Mohammad Reza Sadeghi, Afsaneh Mohammadzadeh, Atousa Karimi, Sheyda Jouhari, Soheila Ansaripour
Background: Endometrium undergoes several changes in structure and cellular composition during pregnancy. Granulocyte Colony-stimulating Factor (GCS-F) is an important cytokine with critical role in embryo implantation and pregnancy. The aim of the present study was to evaluate the impact of intrauterine injection of G-CSF in patients who suffer from unexplained recurrent miscarriage (RM). Methods: In the present randomized clinical trial, a total of 68 patients were randomly allocated into two study groups including intrauterine G-CSF (n=23, 300 μg) injection and control group (n=27, no G-CSF injection)...
October 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29199806/selective-progesterone-receptor-modulators-new-possibilities-for-gynecologic-hormone-therapy
#3
Nanna Sarvilinna, Leila Unkila-Kallio, Päivi Härkki, Aila Tiitinen, Oskari Heikinheimo
Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29169973/-maternal-death-by-venous-thromboembolic-disease
#4
M Rossignol, E Morau, M Dreyfus
Pregnancy and postpartum are very high-risk periods for venous thromboembolism events (TEE), which seems to extend far beyond the classical 6-8 weeks after childbirth. Pulmonary embolism (PE) is one of the 3 main causes of direct maternal death in western countries. Between 2010 an 2012 in France, 24 deaths were related to PE giving a maternal mortality ratio of 1/100,000, which is not different from the former report (2007-2009). PE is responsible of 9% of maternal deaths, in equal position with postpartum hemorrhage and amniotic fluid embolism...
November 20, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29168022/no-advantage-of-fresh-blastocyst-versus-cleavage-stage-embryo-transfer-in-women-under-the-age-of-39-a-randomized-controlled-study
#5
Paolo Emanuele Levi-Setti, Federico Cirillo, Antonella Smeraldi, Emanuela Morenghi, Giulia E G Mulazzani, Elena Albani
PURPOSE: Is there a difference in implantation and pregnancy rates between embryos transferred electively at cleavage or blastocyst stage in infertile women ≤ 38 years with at least four zygotes on day 1 post retrieval? METHODS: A randomized clinical trial was conducted in a single tertiary care hospital with a sample size of 194 patients in each arm for a total population of 388 women. Patients less than 39 years of age with more than three fertilized oocytes and less than four previous assisted reproductive technology (ART) attempts were inclusion criteria...
November 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29163762/bmal1-facilitates-trophoblast-migration-and-invasion-via-sp1-dnmt1-dab2ip-pathway-in-recurrent-spontaneous-abortion
#6
Shang Li, Junyu Zhai, Jiansheng Liu, Yan Hong, Weixiu Zhao, Aimin Zhao, Kang Sun, Yanzhi Du, Zi-Jiang Chen
The underlying mechanism about rhythms and epigenetics leading to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been reported to be associated with risk of miscarriage. However, the functional role of BMAL1 in RSA is not fully understood. Previous study shows the descended expression of DNA 5'-cytosine-methyltransferases 1 (DNMT1) in the villous of early pregnancy loss...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154779/letrozole-pre-treatment-prior-to-medical-termination-of-pregnancy-a-systematic-review
#7
Christopher M Nash, Lauren Philp, Prakesh Shah, Kellie E Murphy
OBJECTIVE(S): The purpose of this systematic review was to evaluate the efficacy of pretreatment with letrozole prior to either a first or second trimester medical termination of pregnancy. STUDY DESIGN: We searched letrozole, femara, aromatase inhibitors, abortifacient agents, termination of pregnancy, and labour induction in MEDLINE, EMBASE, Cochrane Database, Google Scholar, and PubMed from inception of each database until September 2015 with no language limitation...
November 14, 2017: Contraception
https://www.readbyqxmd.com/read/29140582/abortion-knowledge-and-experiences-among-u-s-servicewomen-a-qualitative-study
#8
Kate Grindlay, Jane W Seymour, Laura Fix, Sarah Reiger, Brianna Keefe-Oates, Daniel Grossman
CONTEXT: U.S. servicewomen have a higher rate of unintended pregnancy than civilian women, yet the military does not provide or cover abortion, except in limited circumstances. Servicewomen's experiences with abortion care have received little research attention. METHODS: Twenty-one in-depth interviews with servicewomen who had had an abortion during active-duty service in the prior two years were conducted between January 2015 and July 2016. Women reported on their experiences accessing abortion, as well as their knowledge and opinions of the military's abortion policy...
November 15, 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29122709/evaluation-of-effect-of-letrozole-prior-to-misoprostol-in-comparison-with-misoprostol-alone-in-success-rate-of-induced-abortion
#9
Somayeh Derakhshan-Aydenloo, Tahereh Behroozi-Lak, Farzaneh Broomand
BACKGROUND: Abortion, spontaneous or induced, is a common complication of pregnancy and exploration of available and safe regimens for medical abortion in developing countries seems crucial. AIMS: The present study was aimed to assess the effect of letrozole in combination with misoprostol in women eligible for legal therapeutic abortion with gestational age ≤14weeks. MATERIALS AND METHODS: This clinical randomized trial was conducted on 78 women who were candidate of medical abortion and eligible for legal abortion with gestational age ≤14 weeks that were randomly divided into two groups of case and controls...
November 6, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29080836/identification-of-a-novel-mutation-in-the-fgfr3-gene-in-a-chinese-family-with-hypochondroplasia
#10
Jing Chen, Jiangfei Yang, Suzhou Zhao, Hui Ying, Guimei Li, Chao Xu
BACKGROUND: Hypochondroplasia (HCH; OMIM 146000) is a common autosomal dominant skeletal dysplasia characterized by disproportionate short stature, short extremities, relative macrocephaly, and lumbar lordosis. Because of its clinical and genetic heterogeneity, gene mutational analysis is particularly important in diagnosis and the phenotypes may be ameliorated if diagnosed early. MATERIALS AND METHODS: In this study, we examined a Chinese family with HCH, performed an inductive analysis of their clinical features and radiographic results, and applied targeted exome sequencing (TES) technology to perform a molecular diagnosis...
October 25, 2017: Gene
https://www.readbyqxmd.com/read/29040004/building-bridges-a-case-for-community-health-worker-provision-of-misoprostol-only-abortion-in-the-first-trimester
#11
Claire Tebbets, Diana Santana, José Ros Silvestre, Dee Redwine
INTRODUCTION: The consequences of unsafe abortion are devastating to women, their families, and their communities. Medication abortion presents an important alternative to harmful self-induction practices and surgical intervention under questionable circumstances. In settings where mifepristone is unavailable, the use of misoprostol alone is a safe and effective option for terminating an unwanted pregnancy. Studies have demonstrated the safety and efficacy of administration of misoprostol by community health workers (CHW) for indications such as postpartum hemorrhage and treatment of incomplete abortion...
October 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29024678/suppression-of-nucleocytoplasmic-p27-kip1-export-attenuates-cdk4-mediated-neuronal-death-induced-by-status-epilepticus
#12
Ji-Eun Kim, Tae-Cheon Kang
Aberrant cell cycle re-entry promotes neuronal death in various neurological diseases. Thus, cyclin-dependent kinases (CDKs) seem to be one of potential therapeutic targets to prevent neuronal loss. In the present study, we investigated the involvements of CDK4, CDK5 and p27(Kip1) (an endogenous CDK inhibitor) in status epilepticus (SE)-induced neuronal death. Following SE, CDK4 expression was increased in CA1 neurons, while CDK5 was decreased. Most of TUNEL-positive neurons showed CDK4 expression, but less CDK5 expression...
October 9, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29021145/early-sonographic-detection-of-a-succenturiate-placenta-after-ivf-in-a-42-year-old-woman-with-multiple-comorbidities
#13
Patrick W Stelzl, Ghanshyam Yadav, Lauren Perley, Michelle Silasi
We present a case of a 42-year-old woman with a pregnancy resulting from in vitro fertilisation and a medical history including two spontaneous abortions, hypercoagulable state and other comorbidities. At 13 4/7 weeks' gestation, during research ultrasonography, the patient was noted to have an anterior succenturiate placental lobe. Following an episode of vaginal bleeding at 21 6/7 weeks, she was diagnosed with a low-lying posterior placental lobe. Velamentous cord insertion, placenta previa and vasa previa were excluded at that time...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28969631/women-s-experiences-seeking-informal-sector-abortion-services-in-cape-town-south-africa-a-descriptive-study
#14
Caitlin Gerdts, Sarah Raifman, Kristen Daskilewicz, Mariette Momberg, Sarah Roberts, Jane Harries
BACKGROUND: In settings where abortion is legally restricted, or permitted but not widely accessible, women face significant barriers to abortion access, sometimes leading them to seek services outside legal facilities. The advent of medication abortion has further increased the prevalence of informal sector abortion. This study investigates the reasons for attempting self-induction, methods used, complications, and sources of information about informal sector abortion, and tests a specific recruitment method which could lead to improved estimates of informal sector abortion prevalence among an at-risk population...
October 2, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28969481/delivery-through-cervicovaginal-fistula-literature-review-and-case-report
#15
Rafał Watrowski, Burghardt Babbel, Gerald Gitsch
Less than 10 deliveries via cervicovaginal fistula (CVF) with closed cervical os were reported so far. In the majority of cases, the patients had a history of induced abortions. The CVF was usually recognized due to postpartum hemorrhage. The facilitating role of prostaglandins used for labor induction was supposed. In all cases, the babies remained unaffected by the delivery route. We report a new case of a 37-year-old gravida 2, para 0, with a history of a paracervical tear following a first trimester abortion 11 years ago...
October 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28951537/tim-3-signaling-in-peripheral-nk-cells-promotes-maternal-fetal-immune-tolerance-and-alleviates-pregnancy-loss
#16
Yanhong Li, Jiayuan Zhang, Di Zhang, Xiaowu Hong, Yu Tao, Songcun Wang, Yuanyuan Xu, Hailan Piao, Weijie Yin, Min Yu, Yin Zhang, Qiang Fu, Dajin Li, Xing Chang, Meirong Du
Pregnancy loss occurs in about 15% of clinically recognized pregnancies, and defective maternal-fetal immune tolerance contributes to more than 50% of these events. We found that signaling by the type I membrane protein T cell immunoglobulin and mucin-containing protein 3 (Tim-3) in natural killer (NK) cells had an essential protective role during early pregnancy. Tim-3 on peripheral NK (pNK) cells was transiently increased in abundance during the first trimester of pregnancy, which depended on interleukin-4 (IL-4)-signal transducer and activator of transcription 6 (STAT6) and progesterone signaling...
September 26, 2017: Science Signaling
https://www.readbyqxmd.com/read/28917126/effects-of-a-single-administration-of-different-gonadotropins-on-day-7%C3%A2-post-insemination-on-pregnancy-outcomes-of-rabbit-does
#17
N M Hashem, Z R Aboul-Ezz
This study aimed to investigate the effects of a single administration of one of three different gonadotropins on Day 7 post-insemination on ovarian activity, progesterone (P4) concentration and pregnancy outcomes of rabbit does. Multiparous, non-lactating, V-line does were artificially inseminated after synchronization and ovulation induction with equine chorionic gonadotropin (eCG; 25 IU im) and gonadotropin releasing hormone (GnRH; 0.8  μg buserelin im) 48 h later. On Day 7 post-inseminarion, does were randomly allocated into four groups (n = 40/group)...
January 1, 2018: Theriogenology
https://www.readbyqxmd.com/read/28898687/outcomes-of-mifepristone-usage-for-cervical-ripening-and-induction-of-labour-in-full-term-pregnancy-randomized-controlled-trial
#18
Oleg R Baev, Valentina P Rumyantseva, Oleg V Tysyachnyu, Olga A Kozlova, Gennady T Sukhikh
OBJECTIVE: The most commonly used approved indications for mifepristone in obstetrics include: termination of early pregnancy, cervical dilatation prior to abortion, labour induction in case of fetal death in utero. Fewer studies have been conducted on the effect of mifepristone on cervical ripening and induction of labour in term pregnancy with a live fetus. The aim of our study was to evaluate efficacy and safety of mifepristone use for cervical ripening and induction of labour versus expectant management in full-term pregnancy...
October 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28807283/neospora-caninum-rop16-play-an-important-role-in-the-pathogenicity-by-phosphorylating-host-cell-stat3
#19
Lei Ma, Gongzhen Liu, Jing Liu, Muzi Li, Heng Zhang, Di Tang, Qun Liu
Neospora caninum is a common cause of abortions in cattle and nervous system dysfunctions in dogs. Our analysis shows that NcROP16 and TgROP16 have similar structures and may have similar functions. To our surprise, we found that similar to the T. gondii RH strain, the N. caninum Nc-1 strain could phosphorylate STAT3(Y705), but in contrast to T. gondii, N. caninum Nc-1 could not phosphorylate STAT6(Y641). We constructed a gene-knockout plasmid and screened ΔNcROP16 strains at the gene, protein and transcription levels...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28793091/-maltreatment-and-discrimination-in-induced-abortion-care-perception-of-women-in-teresina-state-of-piau%C3%A3-brazil
#20
Alberto Pereira Madeiro, Andréa Cronemberger Rufino
Treatment of complications resulting from induced abortion may be hampered by discriminatory attitudes manifested by healthcare professionals in hospitals and abortion services. This article retrieved stories of institutional abuse directed at women who had an induced abortion in illegal and unsafe conditions. Seventy-eight women admitted to a public hospital in Teresina for complications after an induced abortion were interviewed. A semi-structured script was used with questions about practices and itineraries of abortion and institutional violence during hospitalization...
August 2017: Ciência & Saúde Coletiva
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