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https://www.readbyqxmd.com/read/28462399/can-letrozole-plus-hmg-protocol-improve-pregnancy-outcomes-in-frozen-thawed-embryo-transfer-an-rct
#1
Ashraf Aleyasin, Marzieh Aghahosseini, Leili Safdarian, Maryam Noorzadeh, Parvin Fallahi, Zahra Rezaeian, Sedighe Hoseinimosa
BACKGROUND: There are different methods in endometrial preparation for frozen-thawed embryo transfer (FET). OBJECTIVE: The purpose of this study was to compare the live birth rate in the artificial FET protocol (estradiol/ progesterone with GnRH-agonist) with stimulated cycle FET protocol (letrozole plus HMG). MATERIALS AND METHODS: This randomized clinical trial included 100 women (18-42 years) randomly assigned to two groups based on Bernoulli distribution...
February 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28461878/clinical-audit-of-ectopic-pregnancy
#2
Alaa Aldin Abdel Hamid, Almraghy Yousry, Safwat Abd El Radi, Omar Mamdouh Shabaan, Elzahry Mazen, Halal Nabil
OBJECTIVE: The aim of this study was to determine the risk factors of ectopic pregnancy in cases presented to the Woman's Health Hospital (WHH) in Assuit University, and to perform clinical audit on strategies for management of ectopic pregnancy in the WHH. METHODS: This descriptive hospital based study was conducted at the Woman's Health Hospital (WHH) of Assuit University (Egypt). There were 210 patients who were admitted to the WHH with the diagnosis of ectopic pregnancy in the period between February 1, 2015 through the end of October 2015...
March 2017: Electronic Physician
https://www.readbyqxmd.com/read/28444176/-j-waves-induced-after-short-coupling-intervals-a-manifestations-of-latent-depolarization-abnormality
#3
Yoshifusa Aizawa, Masafumi Nakayama, Masahito Sato, Masaaki Okabe, Yoshiyasu Aizawa, Seiji Takatsuki, Keiichi Fukuda
Aims: To confirm the presence of tachycardia-induced slur or notch in the terminal portion of the QRS complexes in a general patient population. Methods and results: A tachycardia-induced J wave was defined as a slur or notch in the terminal portion of the QRS complexes newly induced at short RR intervals during atrial premature contractions (APCs) or atrial electrical stimulation in the electrophysiological study (EPS). Twenty-three out of 2000 patients with general diseases were involved...
April 24, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28397981/a-randomized-trial-of-local-endometrial-injury-during-ovulation-induction-cycles
#4
Medhat E E Helmy, Mohammad A Maher, Nabih I Elkhouly, Mahmoud Ramzy
OBJECTIVE: To investigate the effect of endometrial injury on pregnancy outcomes among infertile women taking clomifene citrate. METHODS: A prospective randomized trial was undertaken at an Egyptian hospital between January 26, 2015, and July 17, 2016. Eligible women (≥1 year primary/secondary/unexplained infertility, aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal prolactin/thyroid function/uterine cavity, ≥1 patent tube, male partner with normal semen count and motility, 3 cycles of clomifene citrate without success) were randomly allocated (1:1) using computer-generated numbers into intervention (received endometrial injury on cycle day 15-24) or control groups (sham procedure)...
April 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28394550/refractory-bradycardia-a-rare-complication-of-carboprost-tromethamine-for-induction-of-abortion
#5
Jasna Čerkez Habek, Dubravko Habek, Dario Gulin
We report a first case of refractory several-hour sinus bradycardia, a rare but already described side effect of intramuscular administration of carboprost tromethamine to induce abortion for medical indication in a patient without cardiovascular and other diseases. After administration of atropine sulfate 3x0.5 mg intravenously without effect, the patient‘s sinus rhythm spontaneously normalized as carboprost was eliminated from the body (it has a 3-hour half-life). It is reasonable to believe that the specific prostaglandin underlay the etiology of bradycardia...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28394463/barriers-to-abortion-care-and-their-consequences-for-patients-traveling-for-services-qualitative-findings-from-two-states
#6
Jenna Jerman, Lori Frohwirth, Megan L Kavanaugh, Nakeisha Blades
CONTEXT: Abortion availability and accessibility vary by state. Especially in areas where services are restricted or limited, some women travel to obtain abortion services in other states. Little is known about the experience of travel to obtain abortion. METHODS: In January and February 2015, in-depth interviews were conducted with 29 patients seeking abortion services at six facilities in Michigan and New Mexico. Eligible women were 18 or older, spoke English, and had traveled either across state lines or more than 100 miles within the state...
April 10, 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/28373351/key-role-of-capsular-polysaccharide-in-the-induction-of-systemic-infection-and-abortion-by-hypervirulent-campylobacter-jejuni
#7
Orhan Sahin, Samantha A Terhorst, Eric R Burrough, Zhangqi Shen, Zuowei Wu, Lei Dai, Yizhi Tang, Paul J Plummer, Ju Ji, Michael J Yaeger, Qijing Zhang
Campylobacter jejuni is a zoonotic pathogen, and a hypervirulent strain, named clone SA, has recently emerged as the predominant cause of ovine abortion in the United States. To induce abortion, orally ingested Campylobacter must translocate across the intestinal epithelium, spread systemically in the circulation, and reach the fetoplacental tissue. Bacterial factors involved in these steps are not well understood. C. jejuni is known to produce capsular polysaccharide (CPS), but the specific role CPS plays in systemic infection and particularly abortion in animals remains to be determined...
April 3, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28337825/expression-of-twist-in-the-first-trimester-trophoblast-and-decidual-tissue-of-women-with-recurrent-pregnancy-losses
#8
Jin Hee Ahn, Hye Ran Park, Chan-Woo Park, Dong-Wook Park, Joanne Kwak-Kim
PROBLEM: In this study, we aim to investigate if the expression of TWIST in the first-trimester placenta and decidua has any association with spontaneous abortion (SAB) and recurrent pregnancy losses (RPL). METHODS: Expression of TWIST was measured in the first-trimester trophoblast and decidual tissues using RT-PCR and immunohistochemistry. Women with a pregnancy loss comprised the study group (AB group) including women with two or more recurrent pregnancy loses (RPL group), and women with a spontaneous abortion who had no history of previous pregnancy losses (SAB group)...
March 24, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28326648/changes-in-expression-of-the-cd200-tolerance-signaling-molecule-and-its-receptor-cd200r-by-villus-trophoblasts-during-first-trimester-missed-abortion-and-in-chronic-histiocytic-intervillositis
#9
David A Clark, Jennifer M Dmetrichuk, Elizabeth McCready, Sukhbinder Dhesy-Thind, Jorge L Arredondo
PROBLEM: Expression of CD200 at the feto-maternal interface is associated with successful murine and human pregnancy. CD200 binding to CD200 receptors on lymphomyeloid cells suppresses inflammation and induces Tregs. CD200 receptors are also expressed on mouse and human placental trophoblast cells. What is the expression of CD200 and CD200R in human missed abortions which have preserved Treg levels and in chronic histiocytic intervillositis (CHI) where maternal inflammatory cells cause IUGR? METHODS: Immunohistiochemistry for CD200, CD200R, and Ki67 using human placental sections from missed abortions, term placenta, and CHI...
March 22, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28315926/dissection-of-a-major-qtl-qhir1-conferring-maternal-haploid-induction-ability-in-maize
#10
Sudha K Nair, Willem Molenaar, Albrecht E Melchinger, Prasanna M Boddupalli, Leocadio Martinez, Luis Antonio Lopez, Vijay Chaikam
Among the qhir11 and qhir12 sub-regions of a major QTL qhir1, only qhir11 has significant effect on maternal haploid induction, segregation distortion and kernel abortion. In vivo haploid induction in maize can be triggered in high frequencies by pollination with special genetic stocks called haploid inducers. Several genetic studies with segregating populations from non-inducer x inducer crosses identified a major QTL, qhir1, on chromosome 1.04 contributing to in vivo haploid induction. A recent Genome Wide Association Study using 51 inducers and 1482 non-inducers also identified two sub-regions within the qhir1 QTL region, named qhir11 and qhir12; qhir12 was proposed to be mandatory for haploid induction because the haplotype of qhir11 was also present in some non-inducers and putative candidate genes coding for DNA and amino acid binding proteins were identified in the qhir12 region...
March 18, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28298904/rna-primer-extension-hinders-dna-synthesis-by-escherichia-coli-mutagenic-dna-polymerase-iv
#11
Tommy F Tashjian, Ida Lin, Verena Belt, Tiziana M Cafarelli, Veronica G Godoy
In Escherichia coli the highly conserved DNA damage regulated dinB gene encodes DNA Polymerase IV (DinB), an error prone specialized DNA polymerase with a central role in stress-induced mutagenesis. Since DinB is the DNA polymerase with the highest intracellular concentrations upon induction of the SOS response, further regulation must exist to maintain genomic stability. Remarkably, we find that DinB DNA synthesis is inherently poor when using an RNA primer compared to a DNA primer, while high fidelity DNA polymerases are known to have no primer preference...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28282779/sequential-use-of-foley-catheter-with-misoprostol-for-second-trimester-pregnancy-termination-in-women-with-and-without-caesarean-scars-a-prospective-cohort-study
#12
Melih Velipasaoglu, Cem Yagmur Ozdemir, Burcu Ozek, Reyhan Ayaz, Huseyin Mete Tanir
PURPOSE: The aim of this study is to evaluate the effectiveness and safety of misoprostol and Foley catheter in second trimester termination in women with and without caesarean section (CS) scars. MATERIALS AND METHODS: Women with an indication for pregnancy termination between 14 and 22 completed weeks of gestation were included to the study. Enrolled women were allocated into three groups: (1) women with no history of CS, (2) women with one CS and (3) women with ≥2 CS...
February 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28254231/transcervical-double-balloon-catheter-as-an-alternative-and-salvage-method-for-medical-termination-of-pregnancy-in-midtrimester
#13
Yi-An Tu, Chih-Ling Chen, Yen-Ling Lai, Shin-Yu Lin, Chien-Nan Lee
OBJECTIVE: Termination of pregnancy in midtrimester can be performed surgically or medically. The aim of this study was to evaluate the medical methods, and the additional efficacy of using a transcervical double-balloon catheter in midtrimester termination. MATERIALS AND METHODS: In this retrospective study, we included 167 pregnant women admitted during the period from January 1, 2011, to June 31, 2015, who were between 14 weeks and 28 weeks of gestation, and underwent intended termination of pregnancy at our center...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28224721/progesterone-driven-local-regulatory-t-cell-induction-does-not-prevent-fetal-loss-in-the-cba-j%C3%A3-dba-2j-abortion-prone-model
#14
Anne Schumacher, Dominique Dauven, Ana C Zenclussen
PROBLEM: Best known for its endocrine and immunologic properties, progesterone (P4) is a pivotal player for pregnancy success. However, the immunologic actions underlying P4 protection are not completely understood. Here, we investigated whether P4 application in a murine abortion-prone combination regulates regulatory T cells (Treg) and dendritic cells (DCs) and thereby affects pregnancy outcome. METHOD OF STUDY: Progesterone or vehicle was applied to DBA/2J-mated CBA/J abortion-prone animals in early pregnancy...
March 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28153742/adoption-decision-making-among-women-seeking-abortion
#15
Gretchen Sisson, Lauren Ralph, Heather Gould, Diana Greene Foster
BACKGROUND: Little is known about how adoption factors into pregnancy decision making, particularly when abortion is unavailable. METHODS: We used data from the Turnaway Study, a longitudinal study of 956 women seeking abortion, including 231 women denied abortions owing to gestational limits. Through semiannual quantitative interviews, we assessed the frequency with which women denied abortion considered and choose adoption, and, among adoption participants, decision satisfaction...
January 30, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28109093/-clinical-efficacy-and-safety-of-controlled-release-dinoprostone-insert-a-multicenter-retrospective-study
#16
Xue-Yuan Li, Yue-Wen Guo, Yan-Wen Xu, Bin Zhu, Xue-Xue Wu, Xiang Chen, Xiao-Yi Wang, Dun-Jin Chen, Hui Chen, Jian-Ping Zhang, Zhi-Jian Wang, Sheng-Li An
OBJECTIVE: To analyze the effectiveness and safety of controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province. METHODS: Twenty hospitals using controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province were stratified into provincial hospitals and municipal hospitals, and three hospitals of each level were selected as research units. According to the inclusion and exclusion criteria, 1390 pregnant women receiving term labor induction using controlled-release dinoprostone insert were retrospectively analyzed to evaluate the the effectiveness and safety with another 957 pregnant women with induced abortion using oxytocin as the control group...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28007981/frontline-science-myeloid-derived-suppressor-cells-mdscs-facilitate-maternal-fetal-tolerance-in-mice
#17
Suzanne Ostrand-Rosenberg, Pratima Sinha, Chas Figley, Ramses Long, DoHwan Park, Darryl Carter, Virginia K Clements
During successful pregnancy, a woman is immunologically tolerant of her genetically and antigenically disparate fetus, a state known as maternal-fetal tolerance. How this state is maintained has puzzled investigators for more than half a century. Diverse, immune and nonimmune mechanisms have been proposed; however, these mechanisms appear to be unrelated and to act independently. A population of immune suppressive cells called myeloid-derived suppressor cells (MDSCs) accumulates in pregnant mice and women. Given the profound immune suppressive function of MDSCs, it has been suggested that this cell population may facilitate successful pregnancy by contributing to maternal-fetal tolerance...
May 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27998857/-clinical-outcome-of-in-vitro-fertilization-or-intracytoplasmic-sperm-injection-embryo-transfer-in-women-aged-40-years-and-above
#18
Xing-Yu Zhou, Shu-Xian Feng, Xue-Lan Li, Yu-Dong Liu, Xin Chen, De-Sheng Ye, Jing Niu, Shi-Ling Chen
OBJECTIVE: To investigate the clinical outcomes in vitro fertilization or intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) in women aged over 40 years. METHODS: We retrospectively analyzed 1050 non-donor IVF/ICSI-ET cycles performed from January, 2007 to December, 2015 in women at the age 40 years or above, including 393 women at 40 years of age, 266 at 41 years, 158 at 42 years, 107 at 43 years, 64 at 44 years, and 65 at 45-51 years. The clinical characteristics and outcomes of the women in different age groups were compared and analyzed...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27984035/trends-in-gestational-age-at-time-of-surgical-abortion-for-fetal-aneuploidy-and-structural-abnormalities
#19
Anne R Davis, Sarah K Horvath, Paula M Castaño
BACKGROUND: Screening for fetal aneuploidy has evolved over the past two decades. Whether these advances impact gestational age at abortion has received little study. OBJECTIVE: To describe trends in the gestational age at the time of abortion by fetal diagnosis over an eleven-year study period. We hypothesized that gestational age at time of abortion would decrease for fetal aneuploidy but remain unchanged for structural abnormalities. STUDY DESIGN: We conducted a retrospective case series of all women undergoing surgical abortion for fetal aneuploidy or structural abnormalities up to 24 weeks gestation from 2004 through 2014 in a hospital operating room setting at a single, urban medical center...
October 27, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27910733/a-comparative-morphologic-and-morphometric-study-about-geniculate-ganglion-development-in-man-and-in-rat
#20
Ana Sánchez-Del-Rey, José Maria Sánchez-Fernández, Arantza Ibargutxi, Agustin Martinez-Ibargüen, Francisco Santaolalla
CONCLUSIONS: Human-rat geniculate ganglion (GG) have multiple origins: (1) An initial proximity (20 μm) to the endocranial foramen of the IAM, suggests neural crest induction; and (2) The influence of epibranchial placodes: the tensor tympani muscle (TTM) and the otic apical coil. OBJECTIVES: This study was undertaken to determine the comparative development of human-rat GG. MATERIALS AND METHODS: A light microscopic study of the GG in human material obtained from spontaneous abortions at 9, 13, 14, 17, 18, and 30 weeks, and one neonate was done...
December 2, 2016: Acta Oto-laryngologica
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