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https://www.readbyqxmd.com/read/29467937/temozolomide-sirolimus-and-chloroquine-is-a-new-therapeutic-combination-that-synergizes-to-disrupt-lysosomal-function-and-cholesterol-homeostasis-in-gbm-cells
#1
Sanford P C Hsu, John S Kuo, Hsin-Chien Chiang, Hsin-Ell Wang, Yu-Shan Wang, Cheng-Chung Huang, Yi-Chun Huang, Mau-Shin Chi, Minesh P Mehta, Kwan-Hwa Chi
Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and endogenous cholesterol. We hypothesized that three already approved drugs, the autophagy inducer, sirolimus (rapamycin, Rapa), the autophagy inhibitor, chloroquine (CQ), and DNA alkylating chemotherapy, temozolomide (TMZ) could synergize against GBM...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29454125/management-of-skull-base-tumors-in-the-obstetric-population-a-case-series
#2
Blake H Priddy, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
BACKGROUND: Neoplasms rarely present during pregnancy. However, increase in plasma volume, hormone release induced growth, and tumor hypervascularity, can cause rapid symptoms. These range from not requiring intervention to necessitating emergent operations. OBJECTIVE: We describe an algorithm for the management of symptomatic neoplasm in the obstetric population, and provide recommendations regarding surgical indications and timing. METHODS: Patients who presented to a skull base clinic from 2010-2016 at large tertiary care hospital were reviewed to identify patients who presented with a skull base tumor during pregnancy...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29432414/eat1-transcription-factor-a-non-cell-autonomous-regulator-of-pollen-production-activates-meiotic-small-rna-biogenesis-in-rice-anther-tapetum
#3
Seijiro Ono, Hua Liu, Katsutoshi Tsuda, Eigo Fukai, Keisuke Tanaka, Takuji Sasaki, Ken-Ichi Nonomura
The 24-nucleotides (nt) phased secondary small interfering RNA (phasiRNA) is a unique class of plant small RNAs abundantly expressed in monocot anthers at early meiosis. Previously, 44 intergenic regions were identified as the loci for longer precursor RNAs of 24-nt phasiRNAs (24-PHASs) in the rice genome. However, the regulatory mechanism that determines spatiotemporal expression of these RNAs has remained elusive. ETERNAL TAPETUM1 (EAT1) is a basic-helix-loop-helix (bHLH) transcription factor indispensable for induction of programmed cell death (PCD) in postmeiotic anther tapetum, the somatic nursery for pollen production...
February 12, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29394394/phosphatidylinositol-3-kinase-at-the-very-early-symbiont-perception-a-local-nodulation-control-under-stress-conditions
#4
Germán Robert, Nacira Muñoz, Xochitl Alvarado-Affantranger, Laura Saavedra, Vanina Davidenco, Margarita Rodríguez-Kessler, Georgina Estrada-Navarrete, Federico Sánchez, Ramiro Lascano
Root hair curling is the early and essential morphological change for the success of the symbiotic interaction between legumes and rhizobia. At this stage rhizobia grow as infection thread within root hair and are internalized into the plant cells via endocytosis, where PI3K enzyme plays important roles. Former studies of our group showed that stress conditions affect previous stages of the symbiotic interaction, from 2 to 30 min post-inoculation, which we call as very early host-responses, and affect symbiosis establishment...
January 31, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29392438/letrozole-versus-clomiphene-citrate-in-polycystic-ovary-syndrome-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Shifu Hu, Qiong Yu, Yingying Wang, Mei Wang, Wei Xia, Changhong Zhu
PURPOSE: Polycystic ovary syndrome (PCOS) is a common endocrine disturbance affecting women in the reproductive age group. The present study aimed to compare the effects of letrozole (LE) and clomiphene citrate (CC) for ovulation induction in women with PCOS. METHODS: The PUBMED, Web of Science, and EMBASE databases were screened systematically for randomized controlled trials (RCTs) published from database inception to July 2017. RESULTS: Eleven RCTs involving 2255 patients were included, and data were independently extracted and analyzed using 95% risk ratios (RRs) and confidence intervals (CIs) based on a random- or fixed-effect model (as appropriate)...
February 1, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29391674/comparison-of-mifepristone-followed-by-misoprostol-with-misoprostol-alone-for-treatment-of-early-pregnancy-failure-a-randomized-double-blind-placebo-controlled-trial
#6
Priya Sinha, Amita Suneja, Kiran Guleria, Richa Aggarwal, Neelam B Vaid
Objective: To compare the efficacy and safety of mifepristone followed by misoprostol with misoprostol alone in the management of early pregnancy failure (EPF). Study Design: A randomized double-blind placebo-controlled clinical trial. Methods: Ninety-two women with EPF ≤12 weeks were recruited and randomly allocated to receive either mifepristone 200 mg (n = 46) or placebo (n = 46). Forty-eight hours later, patients in both the groups were given 800 µg misoprostol per-vaginum...
February 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29306558/high-dose-phenobarbitone-coma-in-pediatric-refractory-status-epilepticus-a-retrospective-case-record-analysis-a-proposed-protocol-and-review-of-literature
#7
Sheffali Gulati, Vishal Sondhi, Biswaroop Chakrabarty, Prashant Jauhari, Rakesh Lodha, Jhuma Sankar
BACKGROUND: Ongoing refractory status epilepticus is associated with significant morbidity and mortality. Therapeutic coma induction with midazolam, thiopentone, phenobarbitone or propofol is indicated when conventional antiepileptics fail to abort seizure. Of these, the most extensively studied is midazolam. Amongst the remaining three, phenobarbitone has the most favourable pharmacological profile, but has not been studied adequately, more so in the pediatric age group. The current retrospective case records analysis is an attempt to describe use of phenobarbitone coma in pediatric refractory status epilepticus...
January 3, 2018: Brain & Development
https://www.readbyqxmd.com/read/29278144/a-functional-general-stress-response-of-bradyrhizobium-diazoefficiens-is-required-for-early-stages-of-host-plant-infection
#8
Raphael Ledermann, Ilka Bartsch, Barbara Müller, Janine Wülser, Hans-Martin Fischer
Phylogenetically diverse bacteria respond to various stress conditions by mounting a general stress response (GSR) resulting in the induction of protecting or damage repair functions. In α-proteobacteria, the GSR is induced by a regulatory cascade consisting of the extracytoplasmic function (ECF) σ factor σEcfG, its anti-σ factor NepR and the anti-anti-σ factor PhyR. We have reported previously that σEcfG and PhyR of Bradyrhizobium diazoefficiens (formerly named Bradyrhizobium japonicum), the nitrogen-fixing root nodule symbiont of soybean and related legumes, are required for efficient symbiosis, however, the precise role of the GSR remained undefined...
December 26, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29245250/inositol-supplement-improves-clinical-pregnancy-rate-in-infertile-women-undergoing-ovulation-induction-for-icsi-or-ivf-et
#9
REVIEW
Xiangqin Zheng, Danmei Lin, Yulong Zhang, Yuan Lin, Jianrong Song, Suyu Li, Yan Sun
OBJECTIVE: Pretreatment of myoinositol is a very new method that was evaluated in multiple small studies to manage poor ovarian response in assisted reproduction. This study was to determine the efficacy of myoinositol supplement in infertile women undergoing ovulation induction for intracytoplasmic sperm injection (ICSI) or in vitro fertilization embryo transfer (IVF-ET). METHODS: A meta-analysis and systematic review of published articles evaluating the efficacy of myo-inositol in patients undergoing ovulation induction for ICSI or IVF-ET was performed...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29210341/-without-this-program-women-can-lose-their-lives-migrant-women-s-experiences-with-the-safe-abortion-referral-programme-in-chiang-mai-thailand
#10
Ellen Tousaw, Ra Khin La, Grady Arnott, Orawee Chinthakanan, Angel M Foster
For displaced and migrant women in northern Thailand, access to health care is often limited, unwanted pregnancy is common, and unsafe abortion is a major contributor to maternal death and disability. Based on a pilot project and situational analysis research, in 2015 a multinational team introduced the Safe Abortion Referral Programme (SARP) in Chiang Mai, Thailand, to reduce the socio-linguistic, economic, documentation, and transportation barriers women from Burma face in accessing safe and legal abortion care in Thailand...
December 6, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29201668/efficacy-of-intrauterine-injection-of-granulocyte-colony-stimulating-factor-g-csf-on-treatment-of-unexplained-recurrent-miscarriage-a-pilot-rct-study
#11
Simin Zafardoust, Mohammad Mehdi Akhondi, Mohammad Reza Sadeghi, Afsaneh Mohammadzadeh, Atousa Karimi, Sheyda Jouhari, Soheila Ansaripour
Background: Endometrium undergoes several changes in structure and cellular composition during pregnancy. Granulocyte Colony-stimulating Factor (GCS-F) is an important cytokine with critical role in embryo implantation and pregnancy. The aim of the present study was to evaluate the impact of intrauterine injection of G-CSF in patients who suffer from unexplained recurrent miscarriage (RM). Methods: In the present randomized clinical trial, a total of 68 patients were randomly allocated into two study groups including intrauterine G-CSF (n=23, 300 μg) injection and control group (n=27, no G-CSF injection)...
October 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29199806/selective-progesterone-receptor-modulators-new-possibilities-for-gynecologic-hormone-therapy
#12
REVIEW
Nanna Sarvilinna, Leila Unkila-Kallio, Päivi Härkki, Aila Tiitinen, Oskari Heikinheimo
Progesterone regulates several female reproductive functions. Progesterone and synthetic progestins derived from it have long been utilized in gynecology. The effects of these steroids in target cells are mediated via progesterone receptors, Progesterone receptors are also the target of action of selective progesterone receptor modulators. Of the molecules of this newer group of drugs, two are presently in clinical use. Mifepristone is used in nonsurgical abortion, in softening of the cervix before surgical abortion, and in the induction of labor in cases of intrauterine death...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29169973/-maternal-death-by-venous-thromboembolic-disease
#13
M Rossignol, E Morau, M Dreyfus
Pregnancy and postpartum are very high-risk periods for venous thromboembolism events (TEE), which seems to extend far beyond the classical 6-8 weeks after childbirth. Pulmonary embolism (PE) is one of the 3 main causes of direct maternal death in western countries. Between 2010 an 2012 in France, 24 deaths were related to PE giving a maternal mortality ratio of 1/100,000, which is not different from the former report (2007-2009). PE is responsible of 9% of maternal deaths, in equal position with postpartum hemorrhage and amniotic fluid embolism...
November 20, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29168022/no-advantage-of-fresh-blastocyst-versus-cleavage-stage-embryo-transfer-in-women-under-the-age-of-39-a-randomized-controlled-study
#14
Paolo Emanuele Levi-Setti, Federico Cirillo, Antonella Smeraldi, Emanuela Morenghi, Giulia E G Mulazzani, Elena Albani
PURPOSE: Is there a difference in implantation and pregnancy rates between embryos transferred electively at cleavage or blastocyst stage in infertile women ≤ 38 years with at least four zygotes on day 1 post retrieval? METHODS: A randomized clinical trial was conducted in a single tertiary care hospital with a sample size of 194 patients in each arm for a total population of 388 women. Patients less than 39 years of age with more than three fertilized oocytes and less than four previous assisted reproductive technology (ART) attempts were inclusion criteria...
November 22, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29163762/bmal1-facilitates-trophoblast-migration-and-invasion-via-sp1-dnmt1-dab2ip-pathway-in-recurrent-spontaneous-abortion
#15
Shang Li, Junyu Zhai, Jiansheng Liu, Yan Hong, Weixiu Zhao, Aimin Zhao, Kang Sun, Yanzhi Du, Zi-Jiang Chen
The underlying mechanism about rhythms and epigenetics leading to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. Brain and muscle ARNT-like protein 1 (BMAL1) is considered as a crucial role in fertility, and polymorphism of BMAL1 gene has been reported to be associated with risk of miscarriage. However, the functional role of BMAL1 in RSA is not fully understood. Previous study shows the descended expression of DNA 5'-cytosine-methyltransferases 1 (DNMT1) in the villous of early pregnancy loss...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154779/letrozole-pre-treatment-prior-to-medical-termination-of-pregnancy-a-systematic-review
#16
Christopher M Nash, Lauren Philp, Prakesh Shah, Kellie E Murphy
OBJECTIVE(S): The purpose of this systematic review was to evaluate the efficacy of pretreatment with letrozole prior to either a first or second trimester medical termination of pregnancy. STUDY DESIGN: We searched letrozole, femara, aromatase inhibitors, abortifacient agents, termination of pregnancy, and labour induction in MEDLINE, EMBASE, Cochrane Database, Google Scholar, and PubMed from inception of each database until September 2015 with no language limitation...
November 14, 2017: Contraception
https://www.readbyqxmd.com/read/29140582/abortion-knowledge-and-experiences-among-u-s-servicewomen-a-qualitative-study
#17
Kate Grindlay, Jane W Seymour, Laura Fix, Sarah Reiger, Brianna Keefe-Oates, Daniel Grossman
CONTEXT: U.S. servicewomen have a higher rate of unintended pregnancy than civilian women, yet the military does not provide or cover abortion, except in limited circumstances. Servicewomen's experiences with abortion care have received little research attention. METHODS: Twenty-one in-depth interviews with servicewomen who had had an abortion during active-duty service in the prior two years were conducted between January 2015 and July 2016. Women reported on their experiences accessing abortion, as well as their knowledge and opinions of the military's abortion policy...
November 15, 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29122709/evaluation-of-effect-of-letrozole-prior-to-misoprostol-in-comparison-with-misoprostol-alone-in-success-rate-of-induced-abortion
#18
Somayeh Derakhshan-Aydenloo, Tahereh Behroozi-Lak, Farzaneh Broomand
BACKGROUND: Abortion, spontaneous or induced, is a common complication of pregnancy and exploration of available and safe regimens for medical abortion in developing countries seems crucial. AIMS: The present study was aimed to assess the effect of letrozole in combination with misoprostol in women eligible for legal therapeutic abortion with gestational age ≤14weeks. MATERIALS AND METHODS: This clinical randomized trial was conducted on 78 women who were candidate of medical abortion and eligible for legal abortion with gestational age ≤14 weeks that were randomly divided into two groups of case and controls...
November 6, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29080836/identification-of-a-novel-mutation-in-the-fgfr3-gene-in-a-chinese-family-with-hypochondroplasia
#19
Jing Chen, Jiangfei Yang, Suzhou Zhao, Hui Ying, Guimei Li, Chao Xu
BACKGROUND: Hypochondroplasia (HCH; OMIM 146000) is a common autosomal dominant skeletal dysplasia characterized by disproportionate short stature, short extremities, relative macrocephaly, and lumbar lordosis. Because of its clinical and genetic heterogeneity, gene mutational analysis is particularly important in diagnosis and the phenotypes may be ameliorated if diagnosed early. MATERIALS AND METHODS: In this study, we examined a Chinese family with HCH, performed an inductive analysis of their clinical features and radiographic results, and applied targeted exome sequencing (TES) technology to perform a molecular diagnosis...
October 25, 2017: Gene
https://www.readbyqxmd.com/read/29040004/building-bridges-a-case-for-community-health-worker-provision-of-misoprostol-only-abortion-in-the-first-trimester
#20
Claire Tebbets, Diana Santana, José Ros Silvestre, Dee Redwine
INTRODUCTION: The consequences of unsafe abortion are devastating to women, their families, and their communities. Medication abortion presents an important alternative to harmful self-induction practices and surgical intervention under questionable circumstances. In settings where mifepristone is unavailable, the use of misoprostol alone is a safe and effective option for terminating an unwanted pregnancy. Studies have demonstrated the safety and efficacy of administration of misoprostol by community health workers (CHW) for indications such as postpartum hemorrhage and treatment of incomplete abortion...
October 17, 2017: Journal of Women's Health
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