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https://www.readbyqxmd.com/read/28944753/asymmetry-of-movements-in-cftr-s-two-atp-sites-during-pore-opening-serves-their-distinct-functions
#1
Ben Sorum, Beáta Töröcsik, László Csanády
CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, is opened by ATP binding to two cytosolic nucleotide binding domains (NBDs), but pore-domain mutations may also impair gating. ATP-bound NBDs dimerize occluding two nucleotides at interfacial binding sites; one site hydrolyzes ATP, the other is inactive. The pore opens upon tightening, and closes upon disengagement, of the catalytic site following ATP hydrolysis. Extent, timing, and role of non-catalytic-site movements are unknown. Here we exploit equilibrium gating of a hydrolysis-deficient mutant and apply F value analysis to compare timing of opening-associated movements at multiple locations, from the cytoplasmic ATP sites to the extracellular surface...
September 25, 2017: ELife
https://www.readbyqxmd.com/read/28944734/outcomes-based-contracting-experience-research-findings-from-u-s-and-european-stakeholders
#2
Tara Nazareth, John J Ko, Rahul Sasane, Christian Frois, Stephen Carpenter, Sebastian Demean, Ashok Vegesna, Eric Wu, Robert P Navarro
BACKGROUND: Outcomes-based contracts (OBCs), a type of risk-sharing arrangement (RSA), have emerged as a promising avenue for payers to engage with pharmaceutical manufacturers to share risk and improve patient access to medicines via evaluation of real-world outcomes. OBJECTIVE: To assess the level of recent OBC activity and stakeholder perceptions of these arrangements, as well as the outlook for future OBC activity from a payer and manufacturer perspective in the United States and EU-5 (France, Germany, Italy, Spain, and the United Kingdom)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944650/acute-and-overuse-injuries-in-elite-archers
#3
Claudia K Niestroj, Volker Schöffl, Thomas Küpper
BACKGROUND: To evaluate type and incidence of acute and overuse injuries in high level European and German competitive archers. METHODS: Participants of the German National Indoor Championship (DM) 2012 in Solingen, Germany, and European Outdoor Championship (EM) 2012 in Amsterdam, The Netherlands, participated in the study. The design was a retrospective cohort study performed by a questionnaire. Data obtained included standard personal data (age, gender), training habits, draw weight, competition experience, and detailed data about acute and overuse injuries that occurred during the entire sporting career of the archers...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944649/neuromuscular-responses-and-physiological-patterns-during-a-soccer-simulation-protocol-artificial-turf-versus-natural-grass
#4
Jorge López-Fernández, Jorge García-Unanue, Javier Sánchez-Sánchez, Manuel León, Enrique Hernando, Leonor Gallardo
BACKGROUND: Latest studies suggest similar performance of soccer players either on artificial turf (AT) or natural grass (NG). However, it is not clear if their muscular and physiological responses are also similar on both surfaces. This research aims to assess the influence of game surface on physiological patterns and neuromuscular responses of soccer players during a soccer simulation protocol (SSP) that incorporates repeated sprints and nonlinear actions at maximum speed. METHODS: Sixteen amateur soccer players completed three bouts of the SSP on both AT and NG...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944647/the-effect-of-motor-learning-and-fatigue-on-pre-activation-of-the-lower-extremity-muscles-during-different-jumps
#5
Anna M Kamelska, Bartosz Kot
BACKGROUND: The first step in identifying risk factors for injuries is to characterize the myoelectric activity of different muscles after ground contact, especially when fatigue is a limiting factor. This study aimed at: (a) recording the myoelectric activity of calf muscles after ground contact during different types of jumps and (b) investigating the effect of motor learning and fatigue on muscle pre-activation. METHODS: Twenty four male students aged 24.3 ± 1...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944540/three-atcesa6-like-members-enhance-biomass-production-by-distinctively-promoting-cell-growth-in-arabidopsis
#6
Huizhen Hu, Ran Zhang, Shengqiu Feng, Youmei Wang, Yanting Wang, Chunfen Fan, Ying Li, Zengyu Liu, René Schneider, Tao Xia, Shi-You Ding, Staffan Persson, Liangcai Peng
Cellulose is an abundant biopolymer and a prominent constituent of plant cell walls. Cellulose is also a central component to plant morphogenesis and contributes the bulk of a plant's biomass. While cellulose synthase (CesA) genes were identified over two decades ago, genetic manipulation of this family to enhance cellulose production has remained difficult. In this study, we show that increasing the expression levels of the three primary cell wall AtCesA6-like genes (AtCesA2, -5, -6), but not AtCesA3, AtCesA9 or secondary cell wall AtCesA7, can promote the expression of major primary wall CesA genes to accelerate primary wall CesA complex (CSCs) particle movement for acquiring long microfibrils and consequently increasing cellulose production in Arabidopsis transgenic lines, as compared with wild type...
September 25, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28944525/effect-of-the-proportion-of-roughage-fed-as-rolled-and-baled-hay-on-repressing-wool-biting-behavior-in-housed-sheep
#7
Chen-Yu Huang, Ken-Ichi Takeda
Wool-biting behavior in housed sheep is a serious animal welfare problem and is difficult to control. Since we have found that sheep fed on rolled hay performed less post-feeding wool-biting than those fed on baled hay, here we mixed these two kinds of hay in four different proportions (0%, 33%, 67% and 100% of rolled hay) to test the effect of rolled hay on repressing wool-biting behavior. We also measured the pulling force needed to remove a piece of rolled hay, baled hay, wool and fresh grass. Wool-biting occurred most frequently in the treatment containing 0% rolled hay; however, there was no significant difference between the other three treatments...
September 25, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28944516/innovation-or-violation-leveraging-mobile-technology-to-conduct-socially-responsible-community-research
#8
Amanda L Roy
Mobile technology is increasingly being used to measure individuals' moods, thoughts, and behaviors in real time. Current examples include the use of smartphones to collect ecological momentary assessments (EMAs; assessments delivered "in the moment"); wearable technology to passively collect objective measures of participants' movement, physical activity, sleep, and physiological response; and smartphones and wearable devices with global positioning system (GPS) capabilities to collect precise information about where participants spend their time...
September 25, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28944469/probing-early-motion-processing-with-eye-movements-differences-of-vestibular-migraine-migraine-with-and-without-aura-in-the-attack-free-interval
#9
S Rogalinski, H A Rambold
BACKGROUND: Migraineurs, in between headache attacks, have a different sensitivity to sensory motion stimuli compared to non-migraineurs. METHODS: This cross-sectional laboratory study examines the motion processing in migraineurs using ocular following responses (OFR) elicited by large field random dot patterns and open-loop smooth pursuit eye movements (PS) elicited by a single target moving on a homogenous background. Eye movements were recorded with a video-oculographic system (EyeSeeTec(®) ) and stimuli presented on a CRT at 100 Hz repetition rate to horizontal stimuli of a velocity of 2...
September 25, 2017: Headache
https://www.readbyqxmd.com/read/28944450/review-dynamic-spatial-models-of-parasite-transmission-in-wildlife-their-structure-applications-and-remaining-challenges
#10
REVIEW
L A White, J D Forester, M E Craft
1.Individual differences in contact rate can arise from host, group, and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livestock, and humans. While dynamic disease models can provide a better understanding of the drivers of spatial spread, the effects of landscape heterogeneity have only been modelled in a few well-studied wildlife systems such as rabies and bovine tuberculosis...
September 25, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28944396/light-induced-piston-nanoengines-ultrafast-shuttling-of-a-styryl-dye-inside-cucurbit-7-uril
#11
Ekaterina Y Chernikova, Daria V Berdnikova, Yuri V Fedorov, Olga A Fedorova, François Maurel, Gediminas Jonusauskas
The combination of photoactive styryl(pyridinium) dyes and cucurbit[7]uril (CB[7]) in an integrated supramolecular system allowed us to design a novel high speed molecular machine based on the fully reversible shuttling motion of the dye inside the CB[7] host cavity. The driving force of this movement is the electrostatic potential change after the occurrence of intramolecular charge transfer in the excited state of the dye molecule that can be externally controlled by light. Steady-state and time-resolved optical spectroscopy as well as DFT calculations provided an unambiguous evidence for the ultrafast piston-like movement of the system between two states...
September 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28944299/geographic-genetic-analysis-of-plasmodium-falciparum-parasite-populations-from-surveys-of-primary-school-children-in-western-kenya
#12
Irene Omedo, Polycarp Mogeni, Kirk Rockett, Alice Kamau, Christina Hubbart, Anna Jeffreys, Lynette Isabella Ochola-Oyier, Etienne P de Villiers, Caroline W Gitonga, Abdisalan M Noor, Robert W Snow, Dominic Kwiatkowski, Philip Bejon
Background. Malaria control, and finally malaria elimination, requires the identification and targeting of residual foci or hotspots of transmission. However, the level of parasite mixing within and between geographical locations is likely to impact the effectiveness and durability of control interventions and thus should be taken into consideration when developing control programs. Methods. In order to determine the geographic-genetic patterns of Plasmodium falciparum parasite populations at a sub-national level in Kenya, we used the Sequenom platform to genotype 111 genome-wide distributed single nucleotide polymorphic (SNP) positions in 2486 isolates collected from children in 95 primary schools in western Kenya...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28944096/sensory-motor-and-intrinsic-mechanisms-of-thalamic-activity-related-to-organic-and-psychogenic-dystonia
#13
K Kobayashi, J H Chien, J H Kim, F A Lenz
The thalamus is a critical module in the circuit which has been associated with movement disorders including dystonia. This circuit extends from cortex to striatum to pallidum to the thalamic nucleus Ventral Lateral anterior (VLa) to cortex and can be studied by activity recorded during thalamic stereotactic surgery for the treatment of dystonia. Neuronal recordings in the VLa nucleus show low frequency modulation of firing that is correlated with and leads the low frequency modulation of EMG activity; this EMG activity is characteristic of dystonia...
June 2017: Journal of Alzheimer's Disease and Parkinsonism
https://www.readbyqxmd.com/read/28944062/coupling-spectral-analysis-and-hidden-markov-models-for-the-segmentation-of-behavioural-patterns
#14
Karine Heerah, Mathieu Woillez, Ronan Fablet, François Garren, Stéphane Martin, Hélène De Pontual
BACKGROUND: Movement pattern variations are reflective of behavioural switches, likely associated with different life history traits in response to the animals' abiotic and biotic environment. Detecting these can provide rich information on the underlying processes driving animal movement patterns. However, extracting these signals from movement time series, requires tools that objectively extract, describe and quantify these behaviours. The inference of behavioural modes from movement patterns has been mainly addressed through hidden Markov models...
2017: Movement Ecology
https://www.readbyqxmd.com/read/28943999/measuring-site-fidelity-and-spatial-segregation-within-animal-societies
#15
Thomas O Richardson, Luca Giuggioli, Nigel R Franks, Ana B Sendova-Franks
Animals often display a marked tendency to return to previously visited locations that contain important resources, such as water, food, or developing brood that must be provisioned. A considerable body of work has demonstrated that this tendency is strongly expressed in ants, which exhibit fidelity to particular sites both inside and outside the nest. However, thus far many studies of this phenomena have taken the approach of reducing an animal's trajectory to a summary statistic, such as the area it covers...
August 2017: Methods in Ecology and Evolution
https://www.readbyqxmd.com/read/28943842/when-non-dominant-is-better-than-dominant-kinesiotape-modulates-asymmetries-in-timed-performance-during-a-synchronization-continuation-task
#16
Riccardo Bravi, Erez J Cohen, Alessio Martinelli, Anna Gottard, Diego Minciacchi
There is a growing consensus regarding the specialization of the non-dominant limb (NDL)/hemisphere system to employ proprioceptive feedback when executing motor actions. In a wide variety of rhythmic tasks the dominant limb (DL) has advantages in speed and timing consistency over the NDL. Recently, we demonstrated that the application of Kinesio(®) Tex (KT) tape, an elastic therapeutic device used for treating athletic injuries, improves significantly the timing consistency of isochronous wrist's flexion-extensions (IWFEs) of the DL...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28943648/causes-and-consequences-of-the-rise-of-populist-radical-right-parties-and-movements-in-europe
#17
REVIEW
Jasper Muis, Tim Immerzeel
This article reviews three strands in the scholarship on the populist radical right (PRR). It covers both political parties and extra-parliamentary mobilization in contemporary European democracies. After definitional issues and case selection, the authors first discuss demand-side approaches to the fortunes of the PRR. Subsequently, supply-side approaches are assessed, namely political opportunity explanations and internal supply-side factors, referring to leadership, organization and ideological positioning...
October 2017: Current Sociology. la Sociologie Contemporaine.
https://www.readbyqxmd.com/read/28943546/diabetic-hemichorea-hemiballism-after-prompt-improvement-in-hyperglycemia
#18
Masayuki Kitagawa, Yoshihiro Yamanaka, Toru Adachi, Junitsu Ito, Kazutoshi Fukase, Ikuro Ohta, Tadashi Katagiri
We herein report a case of hemichorea-hemiballism in an 85-year-old man diagnosed with diabetes at 76 years of age. After a one-year interruption in treatment, he was treated with a low-calorie diet, linagliptin, and nateglinide. Over 51 days, his HbA1c level decreased from 15.8% to 7.7%. After a prompt improvement in his hyperglycemia, he began experiencing involuntary movements in the right upper and lower extremities. T1-weighted magnetic resonance imaging showed a high signal intensity in the left lens nucleus...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943457/clinical-staging-of-fibrodysplasia-ossificans-progressiva-fop
#19
Robert J Pignolo, Frederick S Kaplan
Fibrodyplasia ossificans progressiva (FOP) is an ultra-rare genetic condition of heterotopic ossification (HO) that results in progressive loss of joint function, ultimately rendering movement impossible. Death is most commonly the result of thoracic insufficiency syndrome, or complications related to recurrent respiratory infections. There are no current treatments for FOP, but early and emerging clinical trials offer hope for this devastating disease. With the recent reporting of a comprehensive global natural history study, scales to assess joint dysfunction, and a more accurate prediction of joint survival, it is now possible to construct a conceptual framework for the clinical staging of FOP...
September 21, 2017: Bone
https://www.readbyqxmd.com/read/28943454/coronary-artery-calcium-quantification-on-first-second-and-third-generation-dual-source-ct-a-comparison-study
#20
Marleen Vonder, Gert Jan Pelgrim, Sèvrin E M Huijsse, Holger Haubenreisser, Mathias Meyer, Peter M A van Ooijen, Matthijs Oudkerk, Thomas Henzler, Rozemarijn Vliegenthart
BACKGROUND: Differences in coronary artery calcium (CAC) quantification of successive CT systems of one vendor could impact results of CAC screening and progression studies. The purpose of this study is to compare CAC quantification between three generations of dual-source computed tomography (DSCT) systems. METHODS: Three DSCT generations were used to repeatedly scan an anthropomorphic chest phantom and three inserts. The first and second insert contained 100 small and nine large calcifications, respectively, to determine detectability, and the Agatston and (calibrated) mass score, respectively...
September 8, 2017: Journal of Cardiovascular Computed Tomography
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