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https://www.readbyqxmd.com/read/29031192/growth-and-endocrine-function-in-children-with-dravet-syndrome
#1
Krista Eschbach, Sharon Scarbro, Elizabeth Juarez-Colunga, Victoria Allen, Stephanie Hsu, Kelly Knupp
PURPOSE: Dravet syndrome is an intractable childhood epilepsy syndrome most often associated with an SCN1A mutation. In our clinical practice, several patients with Dravet syndrome were noted to have short stature and endocrine dysfunction. This has not been reported in the literature. Our study aim was to describe growth measurements and endocrine abnormalities in children with Dravet syndrome. METHOD: A retrospective chart review was performed at a single institution...
September 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29029242/germ-cell-neoplasia-in-situ-and-preserved-fertility-despite-suppressed-gonadotropins-in-a-patient-with-testotoxicosis
#2
Li Juel Mortensen, Martin Blomberg Jensen, Peter Christiansen, Ann-Margrethe Rønholt, Anne Jørgensen, Hanne Frederiksen, John E Nielsen, Anand C Loya, Birgitte Grønkær Toft, Niels E Skakkebæk, Ewa Rajpert-De Meyts, Anders Juul
Context: Testotoxicosis is an autosomal dominant, male-limited disorder. Activating mutations in the Luteinizing Hormone Receptor gene (LHCGR) cause high autonomous testosterone secretion resulting in early-onset peripheral precocious puberty. Little is known about long-term consequences of testotoxicosis. Case Description: We present a rare case of a patient followed for 25 years with two remarkable outcomes; preserved fertility and germ cell neoplasia in situ (GCNIS)...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29029190/pharmacokinetics-of-igf-i-in-papp-a2-deficient-patients-growth-response-and-effects-on-glucose-and-bone-density
#3
Catalina Cabrera-Salcedo, Tomoyuki Mizuno, Leah Tyzinski, Melissa Andrew, Alexander A Vinks, Jan Frystyk, Halley Wasserman, Catherine M Gordon, Vivian Hwa, Philippe Backeljauw, Andrew Dauber
Context: PAPP-A2 cleaves IGFBP-3 and -5 releasing free IGF-I. Homozygous mutations in PAPP-A2 result in growth failure with elevated total but low free IGF-I. Objective: To determine the 24-hour pharmacokinetic profile of free and total IGF-I after a dose of rhIGF-I. We describe the growth response and effects on glucose metabolism and bone mineral density (BMD) after one year of rhIGF-I therapy. Design and patients: Three affected siblings, their heterozygous parents, and two healthy controls participated...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29029101/growth-outcomes-after-gh-therapy-of-patients-given-long-term-corticosteroids-for-juvenile-idiopathic-arthritis
#4
Hélène David, Camille Aupiais, Baptiste Louveau, Pierre Quartier, Evelyne Jacqz-Aigrain, Jean-Claude Carel, Dominique Simon
Context: GH therapy may improve statural growth outcomes in patients with severe juvenile idiopathic arthritis (JIA). Objectives: To evaluate the effect of GH treatment on adult height and to identify determinants of growth outcomes in JIA. Design and patients: Data from 58 JIA patients, including 53 given GH, enrolled in three prospective clinical trials between 1997 and 2002 were analyzed. Intervention: GH [0.056 mg/kg/d (IQR, 0...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028834/validation-of-a-theoretically-motivated-approach-to-measuring-childhood-socioeconomic-circumstances-in-the-health-and-retirement-study
#5
Anusha M Vable, Paola Gilsanz, Thu T Nguyen, Ichiro Kawachi, M Maria Glymour
Childhood socioeconomic status (cSES) is a powerful predictor of adult health, but its operationalization and measurement varies across studies. Using Health and Retirement Study data (HRS, which is nationally representative of community-residing United States adults aged 50+ years), we specified theoretically-motivated cSES measures, evaluated their reliability and validity, and compared their performance to other cSES indices. HRS respondent data (N = 31,169, interviewed 1992-2010) were used to construct a cSES index reflecting childhood social capital (cSC), childhood financial capital (cFC), and childhood human capital (cHC), using retrospective reports from when the respondent was <16 years (at least 34 years prior)...
2017: PloS One
https://www.readbyqxmd.com/read/29028492/modelling-an-industrial-anaerobic-granular-reactor-using-a-multi-scale-approach
#6
H Feldman, X Flores-Alsina, P Ramin, K Kjellberg, U Jeppsson, D J Batstone, K V Gernaey
The objective of this paper is to show the results of an industrial project dealing with modelling of anaerobic digesters. A multi-scale mathematical approach is developed to describe reactor hydrodynamics, granule growth/distribution and microbial competition/inhibition for substrate/space within the biofilm. The main biochemical and physico-chemical processes in the model are based on the Anaerobic Digestion Model No 1 (ADM1) extended with the fate of phosphorus (P), sulfur (S) and ethanol (Et-OH). Wastewater dynamic conditions are reproduced and data frequency increased using the Benchmark Simulation Model No 2 (BSM2) influent generator...
September 20, 2017: Water Research
https://www.readbyqxmd.com/read/29028482/adiposity-phenotypes-are-associated-with-type-2-diabetes-lap-index-body-adiposity-index-and-neck-circumference
#7
Aline Marcadenti, Flavio D Fuchs, Leila B Moreira, Miguel Gus, Sandra C Fuchs
BACKGROUND AND AIMS: Adiposity phenotypes can be detected by anthropometric indexes associated with type-2 diabetes mellitus (T2DM). Besides body mass index (BMI) and waist circumference (WC), new indices seem to be able to identify T2DM. This study aimed to evaluate independent associations of T2DM with lipid accumulation product (LAP index), neck circumference (NC) and body adiposity index (BAI) in patients with hypertension. METHODS: A cross-sectional study was carried out among 430 patients with hypertension...
September 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29028449/geometric-characteristics-of-the-knee-are-associated-with-a-noncontact-acl-injury-to-the-contralateral-knee-after-unilateral-acl-injury-in-young-female-athletes
#8
James G Levins, Erin C Argentieri, Daniel R Sturnick, Mack Gardner-Morse, Pamela M Vacek, Timothy W Tourville, Robert J Johnson, James R Slauterbeck, Bruce D Beynnon
BACKGROUND: Contralateral anterior cruciate ligament (CACL) injury after recovery from a first-time ACL rupture occurs at a high rate in young females; however, little is known about the risk factors associated with bilateral ACL trauma. HYPOTHESIS: The geometric characteristics of the contralateral knee at the time of the initial ACL injury are associated with risk of suffering a CACL injury in these female athletes. STUDY DESIGN: Case-control study; Level of evidence, 3...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29027951/effects-of-maternal-low-energy-diet-during-gestation-on-intestinal-morphology-disaccharidase-activity-and-immune-response-to-lipopolysaccharide-challenge-in-pig-offspring
#9
Yuling Chen, Daolin Mou, Liang Hu, Jie Zhen, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Bin Feng, Jian Li, De Wu
Maternal nutrition during gestation is involved in the offspring's intestinal development and immunity. The aim of this study was to (1) determine the effects of maternal energy on intestinal digestion and absorption function in offspring, using pigs as a model; and (2) to evaluate the potential effect and mechanisms of maternal energy in modulating immune responses of lipopolysaccharide (LPS)-challenged piglets. After mating, thirty-six nine-parity sows (Landrace × Yorkshire), body weight (BW) (initial body weight 233...
October 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29027602/combining-risk-communication-strategies-to-simultaneously-convey-the-risks-of-four-diseases-associated-with-physical-inactivity-to-socio-demographically-diverse-populations
#10
Eva Janssen, Robert A C Ruiter, Erika A Waters
A single risk factor can increase the risk of developing multiple diseases, but most risk communication research has been conducted in the context of a single disease. We explored which combination of three recommended risk communication strategies is most effective in simultaneously conveying risk estimates of four diseases associated with physical inactivity: colon cancer, stroke, diabetes, and heart disease. Participants (N = 1161, 50% no college experience, 50% racial/ethnic minority) were shown hypothetical risk estimates for each of the four diseases...
October 13, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29026747/acanthosis-nigricans-a-screening-test-for-insulin-resistance-an-important-risk-factor-for-diabetes-mellitus-type-2
#11
Meera Bhagyanathan, Deepak Dhayanithy, Vijayan Ampaya Parambath, R Bijayraj
BACKGROUND: Acanthosis nigricans (AN) is one of the signs suggestive of high insulin resistance (IR). IR is one of the mechanisms involved in pathogenesis of diabetes mellitus type-2 (DM Type-2). Thus, early detection of IR in children may allow us time to intervene well before the development of DM Type-2. In this study, 62% of children having AN had high IR. In children having both, AN and high body mass index (BMI), the incidence of IR was about 80%. This suggests that these easily detectable parameters alone can be useful in screening children at high risk of developing DM Type-2 in future...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026505/indicator-for-success-of-obesity-reduction-programs-in-adolescents-body-composition-or-body-mass-index-evaluating-a-school-based-health-promotion-project-after-12-weeks-of-intervention
#12
Naser Kalantari, Nastaran Keshavarz Mohammadi, Shahram Rafieifar, Hassan Eini-Zinab, Atefeh Aminifard, Hanieh Malmir, Narjes Ashoori, Sheyda Abdi, Maryam Gholamalizadeh, Saeid Doaei
BACKGROUND: Obesity in adolescence is the strongest risk factor for obesity in adulthood. This study aimed to evaluate the effects of a comprehensive lifestyle intervention on different anthropometric indices in 12-16-year-old boy adolescents after 12 Weeks of Intervention. METHODS: A total of 96 male adolescents from two schools participated in this study. The schools were randomly assigned to intervention (53 students) and control school (43 students). Height and weight of students were measured and their body mass index (BMI) was calculated...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29026442/variation-across-a-wheat-genetic-diversity-panel-for-saccharification-of-hydrothermally-pretreated-straw
#13
Samuel R A Collins, David R Wilson, Graham K Moates, Andrea L Harper, Ian Bancroft, Keith W Waldron
BACKGROUND: Wheat straw forms an important, reliable source of lignocellulosic biomass for use in second-generation ethanol production. However, there is limited understanding of the variation in quality of straw from current breeding cultivars, and studies on such variation have generally employed suboptimal pretreatments. There is also a degree of confusion regarding phenotypic characteristics relevant to optimising the enzymatic saccharification of cellulose after suitable pretreatments for biorefining compared with those which determine good ruminant digestibility...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29025206/nonalcoholic-fatty-liver-disease-in-long-term-survivors-of-childhood-onset-craniopharyngioma
#14
So Yoon Jung, Yun Jeong Lee, Hye Jin Lee, Young Ah Lee, Jin Soo Moon, Jae Sung Ko, Sei Won Yang, Choong Ho Shin
PURPOSE: Hypothalamic obesity in childhood-onset (CO-) craniopharyngioma patients may predispose to nonalcoholic fatty liver disease (NAFLD). This study reviewed the characteristics of NAFLD associated with CO-craniopharyngioma. METHODS: This study retrospectively reviewed 75 patients who underwent surgery for craniopharyngioma while younger than 15 years of age between 2000 and 2016. RESULTS: Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) above 40 IU/L was observed in 51 of the 75 (68%) CO-craniopharyngioma patients...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025084/association-between-adult-height-myocardial-infarction-heart-failure-stroke-and-death-a-korean-nationwide-population-based-study
#15
Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Hyun Jung Lee, Tae-Min Rhee, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Si-Hyuck Kang, Seil Oh
Background: The association between adult height and cardiovascular (CV) events and mortality has been suggested, albeit inconsistently. We sought to discover the comprehensive relationship between height, CV-related morbidity and all-cause death according to age. Methods: We investigated the association between adult height and myocardial infarction (MI), heart failure (HF), stroke incidence and mortality in 16 528 128 Korean patients who underwent regular health check-ups (2005-08)...
September 5, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024955/offspring-risk-of-obesity-in-childhood-adolescence-and-adulthood-in-relation-to-gestational-diabetes-mellitus-a-sex-specific-association
#16
Shanshan Li, Yeyi Zhu, Edwina Yeung, Jorge E Chavarro, Changzheng Yuan, Alison E Field, Stacey A Missmer, James L Mills, Frank B Hu, Cuilin Zhang
Background: Animal data suggest sexually dimorphic programming of obesity in response to altered intrauterine environment, but the longitudinal impact of gestational diabetes mellitus (GDM) on sex-specific risk of offspring obesity in humans is unclear. Methods: We conducted a prospective analysis of 15 009 US individuals (7946 female and 7063 male) from the Growing-Up Today Study, who were followed from 1996 (ages 9-14 years) through 2010. Height and weight from validated questionnaires were used to derive body mass index (BMI) at different ages...
August 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024748/effect-of-circulating-tumor-cell-aggregate-configuration-on-hemodynamic-transport-and-wall-contact
#17
Kevin J Anderson, Adelaide de Guillebon, Andrew Hughes, Weiwei Wang, Michael R King
Selectin-mediated adhesion of circulating tumor cells (CTCs) to the endothelium is a critical step in cancer metastasis, which is a major factor contributing to the mortality of cancer. The formation of tethers between tumor cells and endothelial selectins initiates cell rolling, which leads to firm adhesion, extravasation and the formation of secondary metastases. Tumor cells can travel through the bloodstream as single cells, or as aggregates known as circulating tumor microemboli (CTM). CTM have increased survivability and metastatic potential relative to CTCs, and the presence of CTM is associated with worse patient prognosis...
October 9, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29024599/the-effects-of-combined-probiotic-ingestion-and-circuit-training-on-muscular-strength-and-power-and-cytokine-responses-in-young-males
#18
Nur Syazwani Ibrahim, Ayu Suzailiana Muhamad, Foong Kiew Ooi, Jamaayah Meor-Osman, Chee Keong Chen
To our knowledge, the efficacy of combined probiotic supplementation with circuit training has not been evaluated. Thus, we investigated the effects of probiotic supplementation combined with circuit training on isokinetic muscular strength and power and cytokine responses in young males. Forty-eight healthy sedentary young males were recruited and randomised into four separate groups: sedentary placebo control (C), probiotics (P), circuit training with placebo (CT), and circuit training with probiotics (CTP)...
October 12, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29024558/overweight-obesity-and-adiposity-in-survivors-of-childhood-brain-tumours-a-systematic-review-and-meta-analysis
#19
REVIEW
K-W Wang, A Fleming, D L Johnston, S M Zelcer, S R Rassekh, S Ladhani, A Socha, J Shinuda, S Jaber, S Burrow, S K Singh, L Banfield, R J de Souza, L Thabane, M C Samaan
Survivors of childhood brain tumours (SCBT) have increased cardiometabolic risks, but the determinants of these risks are unclear. This systematic review aims to compare the prevalence of overweight and obesity as well as adiposity measures between SCBT and non-cancer controls. The PubMed, EMBASE, MEDLINE, CINAHL and the Cochrane Library databases were searched. The primary outcomes were the prevalence of overweight and obesity based on body mass index. The secondary outcomes were adiposity measures including percent fat mass, waist-to-hip and waist-to-height ratios...
October 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29023899/visceral-adiposity-increases-risk-for-hepatocellular-carcinoma-in-male-patients-with-cirrhosis-and-recurrence-after-liver-transplant
#20
Aldo J Montano-Loza, Vera C Mazurak, Maryam Ebadi, Judith Meza-Junco, Michael B Sawyer, Vickie E Baracos, Norman Kneteman
Visceral adipose tissue (VAT) is a metabolically active organ, associated with higher risk of malignancies. We aimed to evaluate if VAT is associated with the risk of hepatocellular carcinoma (HCC) in patients presenting with cirrhosis as well as HCC recurrence after liver transplantation (LT). Cirrhotic patients (n=678; 457 males) who were assessed for LT (289 with HCC) were evaluated for body composition analysis. Patients who underwent LT (n=247, 168 males) were subsequently evaluated for body composition, and 96 of these patients (78 males) had HCC...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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