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https://www.readbyqxmd.com/read/28817835/history-of-thyroid-disease-and-survival-of-ovarian-cancer-patients-results-from-the-ovarian-cancer-association-consortium-a-brief-report
#1
Albina N Minlikeeva, Jo L Freudenheim, Rikki A Cannioto, Kevin H Eng, J Brian Szender, Paul Mayor, John L Etter, Daniel W Cramer, Brenda Diergaarde, Jennifer A Doherty, Thilo Dörk, Robert Edwards, Anna deFazio, Grace Friel, Marc T Goodman, Peter Hillemanns, Estrid Høgdall, Allan Jensen, Susan J Jordan, Beth Y Karlan, Susanne K Kjær, Rüdiger Klapdor, Keitaro Matsuo, Mika Mizuno, Christina M Nagle, Kunle Odunsi, Lisa Paddock, Mary Anne Rossing, Joellen M Schildkraut, Barbara Schmalfeldt, Brahm H Segal, Kristen Starbuck, Kathryn L Terry, Penelope M Webb, Emese Zsiros, Roberta B Ness, Francesmary Modugno, Elisa V Bandera, Jenny Chang-Claude, Kirsten B Moysich
BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817832/successful-use-of-grenz-rays-for-disseminated-superficial-actinic-porokeratosis-report-of-8-cases
#2
Egle Ramelyte, Matilda Bylaite-Bucinskiene, Reinhard Dummer, Laurence Imhof
BACKGROUND: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success. AIM: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx). METHODS: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Patients with DSAP, who received at least 1 RTx treatment session and who had been followed up for at least 4 weeks were included in the further data analysis...
August 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28817796/the-strange-case-of-aggression-and-the-brain
#3
Vinicius M A Carvalho, Thiago S Nakahara, Fabio Papes
Territorial male mice are aggressive toward intruding males, but socially bonded males are not. Through manipulation of activity in a subset of neurons in the ventromedial hypothalamus, Yang et al. (2017) report that social and physiological factors non-linearly interact to control male aggression.
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28817752/technical-refinements-and-outcomes-of-the-modified-anterior-septal-transplant
#4
Myriam Loyo, Jeffrey D Markey, Deniz Gerecci, Edward El Rassi, Ryan J Li, C Blake Sullivan, Tom D Wang
Importance: Severe anterior septal deviation and resultant nasal obstruction represent a difficult surgical task to correct. The goal of surgery is to straighten the anterior dorsal and caudal struts, while maintaining nasal tip and midvault support. This study presents a novel extracorporeal septoplasty technique to straighten the crooked anterior septum. Objective: To describe the novel anterior septal transplant technique, which consists of complete resection of the caudal septum and reconstruction with extended spreader grafts and a columellar strut, without a separate caudal septal replacement graft...
August 17, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28817741/reconstruction-of-a-severely-atrophied-alveolar-ridge-by-computer-aided-gingival-simulation-and-3d-printed-surgical-guide-a-case-report
#5
In-Seok Song, Mi-Ran Lee, Jae-Jun Ryu, Ui-Lyong Lee
Dental implants positioned in severely atrophied anterior maxillae require esthetic or functional compromises. This case report describes the rehabilitation of a severely atrophied alveolar ridge with a three-dimensional (3D) computer-aided design/computer-aided manufacture (CAD/CAM) surgical guide. A 50-year-old woman had a severely atrophied anterior maxilla with unfavorably positioned dental implants. Functional and esthetic prosthodontic restoration was difficult to achieve. An anterior segmental osteotomy was planned to reposition the dental implants...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28817732/enhanced-inflammation-in-new-zealand-white-rabbits-when-mers-cov-reinfection-occurs-in-the-absence-of-neutralizing-antibody
#6
Katherine V Houser, Andrew J Broadbent, Lisa Gretebeck, Leatrice Vogel, Elaine W Lamirande, Troy Sutton, Kevin W Bock, Mahnaz Minai, Marlene Orandle, Ian N Moore, Kanta Subbarao
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic betacoronavirus that was first detected in humans in 2012 as a cause of severe acute respiratory disease. As of July 28, 2017, there have been 2,040 confirmed cases with 712 reported deaths. While many infections have been fatal, there have also been a large number of mild or asymptomatic cases discovered through monitoring and contact tracing. New Zealand white rabbits are a possible model for asymptomatic infection with MERS-CoV. In order to discover more about non-lethal infections and to learn whether a single infection with MERS-CoV would protect against reinfection, we inoculated rabbits with MERS-CoV and monitored the antibody and inflammatory response...
August 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28817709/assessment-of-physicians-awareness-and-knowledge-of-familial-hypercholesterolemia-in-saudi-arabia-is-there-a-gap
#7
Mohammed Ali Batais, Turky H Almigbal, Aref A Bin Abdulhak, Hani B Altaradi, Khalid F AlHabib
BACKGROUND: The scarcity of familial hypercholesterolemia (FH) cases reported in Saudi Arabia might be indicative of a lack of awareness of this common genetic disease among physicians. OBJECTIVE: To assess physicians' awareness, practice, and knowledge of FH in Saudi Arabia. METHODS: This is a cross-sectional study conducted among physicians at four tertiary hospitals in Riyadh, Saudi Arabia between March 2016 and May 2016 using a self-administered questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28817678/family-based-exome-wide-association-study-of-childhood-acute-lymphoblastic-leukemia-among-hispanics-confirms-role-of-arid5b-in-susceptibility
#8
Natalie P Archer, Virginia Perez-Andreu, Ulrik Stoltze, Michael E Scheurer, Anna V Wilkinson, Ting-Nien Lin, Maoxiang Qian, Charnise Goodings, Michael D Swartz, Nalini Ranjit, Karen R Rabin, Erin C Peckham-Gregory, Sharon E Plon, Pedro A de Alarcon, Ryan C Zabriskie, Federico Antillon-Klussmann, Cesar R Najera, Jun J Yang, Philip J Lupo
We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2...
2017: PloS One
https://www.readbyqxmd.com/read/28817643/peripheral-clinic-versus-centralized-laboratory-based-xpert-mtb-rif-performance-experience-gained-from-a-pragmatic-stepped-wedge-trial-in-botswana
#9
Tefera Agizew, Rosanna Boyd, Ndwapi Ndwapi, Andrew Auld, Joyce Basotli, Sambayawo Nyirenda, Zegabriel Tedla, Anikie Mathoma, Unami Mathebula, Chawangwa Lesedi, Sherri Pals, Anand Date, Heather Alexander, Thomas Kuebrich, Alyssa Finlay
BACKGROUND: In 2011, the Botswana National Tuberculosis Program adopted World Health Organization guidelines and introduced Xpert MTB/RIF (Xpert) assay to support intensified case finding among people living with HIV enrolling in care. An evaluation was designed to assess performance under operational conditions to inform the national Xpert scale-up. METHODS: Xpert was implemented from August 2012 through November 2014 with 13 GeneXpert instruments (GeneXpert) deployed in a phased approach over nine months: nine centralized laboratory and four point-of-care (POC) peripheral clinics...
2017: PloS One
https://www.readbyqxmd.com/read/28817625/disentangling-the-relationship-between-children-s-motor-ability-executive-function-and-academic-achievement
#10
Mirko Schmidt, Fabienne Egger, Valentin Benzing, Katja Jäger, Achim Conzelmann, Claudia M Roebers, Caterina Pesce
Even though positive relations between children's motor ability and their academic achievement are frequently reported, the underlying mechanisms are still unclear. Executive function has indeed been proposed, but hardly tested as a potential mediator. The aim of the present study was therefore to examine the mediating role of executive function in the relationship between motor ability and academic achievement, also investigating the individual contribution of specific motor abilities to the hypothesized mediated linkage to academic achievement...
2017: PloS One
https://www.readbyqxmd.com/read/28817557/erratum-vol-66-no-27
#11
(no author information available yet)
In the report "Pneumococcal Vaccination Among Medicare Beneficiaries Occurring After the Advisory Committee on Immunization Practices Recommendation for Routine Use Of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine for Adults Aged ≥65 Years," on page 732, the second sentence of the discussion should have read "However, approximately 20%-25% of IPD cases and 10% of community-acquired pneumonia cases in adults aged ≥65 years are caused by PCV13 serotypes."
August 18, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28817554/occupational-distribution-of-campylobacteriosis-and-salmonellosis-cases-maryland-ohio-and-virginia-2014
#12
Chia-Ping Su, Marie A de Perio, Kathleen Fagan, Meghan L Smith, Ellen Salehi, Seth Levine, Karen Gruszynski, Sara E Luckhaupt
Campylobacter and Salmonella are leading causes of bacterial gastroenteritis in the United States and are estimated to cause >1 million episodes of domestically acquired illness annually (1). Campylobacter and Salmonella are primarily transmitted through contaminated food, but animal-to-human and human-to-human transmission can also occur (2,3). Although occupationally acquired infections have been reported, occupational risk factors have rarely been studied. In 2015, the Occupational Safety and Health Administration (OSHA) identified 63 suspected or confirmed cases of Campylobacter infection over 3...
August 18, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28817551/progress-toward-poliomyelitis-eradication-afghanistan-january-2016-june-2017
#13
Maureen Martinez, Hemant Shukla, Joanna Nikulin, Mufti Zubair Wadood, Stephen Hadler, Chukwuma Mbaeyi, Rudolph Tangermann, Jaume Jorba, Derek Ehrhardt
Afghanistan, Pakistan, and Nigeria remain the only countries where the transmission of endemic wild poliovirus type 1 (WPV1) continues (1). This report describes polio eradication activities, progress, and challenges in Afghanistan during January 2016-June 2017 and updates previous reports (2,3). Thirteen WPV1 cases were confirmed in Afghanistan in 2016, a decrease of seven from the 20 cases reported in 2015. From January to June 2017, five WPV1 cases were reported, compared with six during the same period in 2016...
August 18, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28817534/radius-regeneration-after-open-fracture-and-extrusion-a-case-report
#14
Kristopher B McCall, David Y Chong
A pediatric patient presenting with an open forearm fracture with segmental defect is rare, and the pediatric orthopedic literature to guide treatment is sparse. There are several described methods to treat the defect, including bone grafting and bone transport techniques. In addition, there are reports of fibular regeneration after resection if the periosteum is left intact. We present a case report of complete regeneration of over half of a pediatric radial shaft with an intact periosteum, after traumatic extrusion from an open fracture...
August 16, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28817489/the-use-of-granulocyte-colony-stimulating-factor-in-clozapine-rechallenge-a-systematic-review
#15
John Lally, Steffi Malik, Amir Krivoy, Eromona Whiskey, David M Taylor, Fiona P Gaughran, Robert J Flanagan, Aleksandar Mijovic, James H MacCabe
PURPOSE/BACKGROUND: Clozapine is associated with hematological abnormalities, with neutropenia and agranulocytosis of most concern. Granulocyte colony-stimulating factor (G-CSF) has been used to support clozapine rechallenge after neutropenia with the aim of maintaining the neutrophil count. This study aims to explore the practice, use, safety, and efficacy of G-CSF in this context. METHODS/PROCEDURES: We conducted a systematic review to identify all studies investigating or describing G-CSF as a prophylaxis to enable continued clozapine treatment during a rechallenge...
August 16, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28817464/biologics-for-idiopathic-inflammatory-myopathies
#16
Siamak Moghadam-Kia, Rohit Aggarwal, Chester V Oddis
PURPOSE OF REVIEW: As treatment of refractory cases of idiopathic inflammatory myopathies (IIMs) has been challenging, there is growing interest in assessing novel biologics that target various pathways implicated in the pathogenesis of IIM. RECENT FINDINGS: In the largest clinical trial in adult and juvenile IIM assessing the effectiveness of rituximab, the primary outcome was not met but 83% of this refractory group of IIM patients met a predefined definition of improvement and rituximab demonstrated a significant glucocorticoid-sparing effect...
August 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28817406/idiopathic-myointimal-hyperplasia-of-mesenteric-veins-an-uncommon-cause-of-ischemic-colitis-with-distinct-mucosal-features
#17
Rhonda K Yantiss, Isabelle Cui, Nicole C Panarelli, Jose Jessurun
Idiopathic myointimal hyperplasia of mesenteric veins causes chronic ischemic mucosal injury with segmental strictures that mimic inflammatory bowel disease and nonocclusive ischemic colitis. It is characterized by myointimal proliferative changes that narrow the lumina of veins combined with ischemic injury and ulcers. Most cases reported to date have been diagnosed following surgical resection. The aim of this study was to determine whether mucosal changes of idiopathic myointimal hyperplasia of mesenteric veins are sufficiently sensitive and specific to allow its recognition in biopsy material...
August 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28817404/primary-renal-sarcomas-with-bcor-ccnb3-gene-fusion-a-report-of-2-cases-showing-histologic-overlap-with-clear-cell-sarcoma-of-kidney-suggesting-further-link-between-bcor-related-sarcomas-of-the-kidney-and-soft-tissues
#18
Pedram Argani, Yu-Chien Kao, Lei Zhang, Carlos Bacchi, Andres Matoso, Rita Alaggio, Jonathan I Epstein, Cristina R Antonescu
We report 2 primary renal sarcomas demonstrating BCOR-CCNB3 gene fusions that have recently been identified in undifferentiated round cell sarcomas of bone and soft tissue. These neoplasms occurred in male children aged 11 and 12 years, and both were cystic as a result of entrapment and dilatation of native renal tubules. Both cases were composed of variably cellular bland spindle cells with fine chromatin set in myxoid stroma and separated by a branching capillary vasculature. Both neoplasms demonstrated immunoreactivity for BCOR, cyclin D1, TLE1, and SATB2 in the spindle neoplastic cells and negativity in the prominent capillary vasculature...
August 16, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28817391/tacrolimus-eye-drops-as-adjunct-therapy-in-severe-corneal-endothelial-rejection-refractory-to-corticosteroids
#19
Reza Ghaffari, Hamed Ghassemi, Mehran Zarei-Ghanavati, Golshan Latifi, Shima Dehghani, Zeeshan Haq, Ali R Djalilian
PURPOSE: To evaluate the safety and efficacy of tacrolimus eye drops as adjunctive therapy in the treatment of severe corneal endothelial rejection after penetrating keratoplasty refractory to corticosteroids. METHODS: In this prospective interventional case series, 11 eyes of 11 patients assessed for severe corneal endothelial rejection, with an inadequate response to topical, local, and systemic corticosteroids, were treated with either 0.01% or 0.05% tacrolimus eye drops 4 times daily...
August 16, 2017: Cornea
https://www.readbyqxmd.com/read/28817388/ophthalmologic-manifestations-of-systemic-vasculitis
#20
George N Papaliodis
PURPOSE OF REVIEW: To review the systemic vasculitides and associated ocular manifestations with emphasis on publications within the last 12 months. RECENT FINDINGS: There are multiple case reports demonstrating atypical ocular manifestations of systemic vasculitis. Often the eye findings are the initial presentation of the disorder and require a high degree of clinical suspicion to evaluate further as these conditions can compromise vision but some may also be life threatening...
August 16, 2017: Current Opinion in Ophthalmology
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