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Chemical exchange saturation transfer

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https://www.readbyqxmd.com/read/28089939/chemical-exchange-saturation-transfer-imaging-advances-and-applications-by-michael-t-mcmahon-assaf-a-gild-jeff-w-m-bulte-and-peter-c-m-van-zijl-publisher-pan-stanford-publishing-pte-ltd-singapore
#1
https://www.readbyqxmd.com/read/28075559/one-component-supramolecular-filament-hydrogels-as-theranostic-label-free-magnetic-resonance-imaging-agents
#2
Lye Lin Lock, Yuguo Li, Xinpei Mao, Hanwei Chen, Verena Staedtke, Renyuan Bai, Wang Ma, Ran Lin, Yi Li, Guanshu Liu, Honggang Cui
Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in the clinic; however, safety concerns associated with their toxicities in the free ionic form have promoted the development of new generations of metal-free contrast agents. Here we report a supramolecular strategy to convert an FDA-approved anticancer drug, Pemetrexed (Pem), to a molecular hydrogelator with inherent chemical exchange saturation transfer (CEST) MRI signals. The rationally designed drug-peptide conjugate can spontaneously associate into filamentous assemblies under physiological conditions and consequently form theranostic supramolecular hydrogels for injectable delivery...
January 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28035783/separating-dipolar-and-chemical-exchange-magnetization-transfer-processes-in-1-h-cest
#3
Tairan Yuwen, Ashok Sekhar, Lewis E Kay
An amide (1) H-Chemical Exchange Saturation Transfer (CEST) experiment is presented for studies of conformational exchange in proteins. The approach, exploiting spin-state-selective magnetization transfer, completely suppresses undesired NOE-based dips in CEST profiles so that chemical exchange processes can be studied. The methodology is demonstrated with applications involving proteins that interconvert on the millisecond timescale between major and invisible minor states, and accurate amide (1) H chemical shifts of the minor conformer are obtained in each case...
December 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/28019053/prestructural-cartilage-assessment-using-mri
#4
Thomas M Link, Jan Neumann, Xiaojuan Li
: Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy...
December 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28012297/balanced-steady-state-free-precession-bssfp-from-an-effective-field-perspective-application-to-the-detection-of-chemical-exchange-bssfpx
#5
Shu Zhang, Zheng Liu, Aaron Grant, Jochen Keupp, Robert E Lenkinski, Elena Vinogradov
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism and it is gaining increasing popularity as many promising applications have been proposed and investigated. Fast and quantitative CEST imaging techniques are further needed in order to increase the applicability of CEST for clinical use as well as to derive quantitative physiological and biological information. Steady-state methods for fast CEST imaging have been reported recently. Here, we observe that an extreme case of these methods is a balanced steady-state free precession (bSSFP) sequence...
December 8, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27997993/longitudinal-imaging-reveals-sub-hippocampal-dynamics-in-glutamate-levels-associated-with-histopathologic-events-in-a-mouse-model-of-tauopathy-and-healthy-mice
#6
Rachelle Crescenzi, Catherine DeBrosse, Ravi P R Nanga, Matthew D Byrne, Guruprasad Krishnamoorthy, Kevin D'Aquilla, Hari Nath, Knashawn H Morales, Michiyo Iba, Hari Hariharan, Virginia M Y- Lee, John A Detre, Ravinder Reddy
Tauopathies are neurodegenerative disorders characterized by abnormal intracellular aggregates of tau protein, and include Alzheimer's disease, corticobasal degeneration, frontotemporal dementia, and traumatic brain injury. Glutamate metabolism is altered in neurodegenerative disorders manifesting in higher or lower concentrations of glutamate, its transporters or receptors. Previously, glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) demonstrated that glutamate levels are reduced in regions of synapse loss in the hippocampus of a mouse model of late-stage tauopathy...
December 20, 2016: Hippocampus
https://www.readbyqxmd.com/read/27992380/noninvasive-amide-proton-transfer-magnetic-resonance-imaging-in-evaluating-the-grading-and-cellularity-of-gliomas
#7
Yan Bai, Yusong Lin, Wei Zhang, Lingfei Kong, Lifu Wang, Panli Zuo, Ignacio Vallines, Benjamin Schmitt, Jie Tian, Xiaolei Song, Jinyuan Zhou, Meiyun Wang
Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27934305/gear-up-for-a-ph-shift-a-responsive-iron-ii-2-amino-6-picolyl-appended-macrocyclic-paracest-agent-that-protonates-at-a-pendent-group
#8
Pavel B Tsitovich, Jordan M Cox, Joseph A Spernyak, Janet R Morrow
Two high-spin Fe(II) and Co(II) complexes of 1,4,7,10-tetraazacyclododecane (CYCLEN) appended with four 2-amino-6-picolyl groups, denoted as [Fe(TAPC)](2+) and [Co(TAPC)](2+), are reported. These complexes demonstrate C2-symmetrical geometry from coordination of two pendents, and they are present in a single diastereomeric form in aqueous solution as shown by (1)H NMR spectroscopy and by a single-crystal X-ray structure for the Co(II) complex. A highly shifted but low-intensity CEST (chemical exchange saturation transfer) signal from NH groups is observed at -118 ppm for [Co(TAPC)](2+) at pH 6...
November 21, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27911361/spin-saturation-transfer-difference-nmr-sstd-nmr-a-new-tool-to-obtain-kinetic-parameters-of-chemical-exchange-processes
#9
María Teresa Quirós, Colin Macdonald, Jesús Angulo, María Paz Muñoz
This detailed protocol describes the new Spin Saturation Transfer Difference Nuclear Magnetic Resonance protocol (SSTD NMR), recently developed in our group to study processes of mutual-site chemical exchange that are difficult to analyze by traditional methods. As the name suggests, this method combines the Spin Saturation Transfer method used for small molecules, with the Saturation Transfer Difference (STD) NMR method employed for the study of protein-ligand interactions, by measuring transient spin saturation transfer along increasing saturation times (build-up curves) in small organic and organometallic molecules undergoing chemical exchange...
November 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27898185/perfusion-has-no-effect-on-the-in-vivo-cest-effect-from-cr-crcest-in-skeletal-muscle
#10
Feliks Kogan, Randall B Stafford, Erin K Englund, Garry E Gold, Hari Hariharan, John A Detre, Ravinder Reddy
Creatine, a key component of muscle energy metabolism, exhibits a chemical exchange saturation transfer (CEST) effect between its amine group and bulk water, which has been exploited to spatially and temporally map creatine changes in skeletal muscle before and after exercise. In addition, exercise leads to an increase in muscle perfusion. In this work, we determined the effects of perfused blood on the CEST effects from creatine in skeletal muscle. Experiments were performed on healthy human subjects (n = 5) on a whole-body Siemens 7T magnetic resonance imaging (MRI) scanner with a 28-channel radiofrequency (RF) coil...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27896628/clinical-translation-of-tumor-acidosis-measurements-with-acidocest-mri
#11
Kyle M Jones, Edward A Randtke, Eriko S Yoshimaru, Christine M Howison, Pavani Chalasani, Robert R Klein, Setsuko K Chambers, Phillip H Kuo, Mark D Pagel
PURPOSE: We optimized acido-chemical exchange saturation transfer (acidoCEST) magnetic resonance imaging (MRI), a method that measures extracellular pH (pHe), and translated this method to the radiology clinic to evaluate tumor acidosis. PROCEDURES: A CEST-FISP MRI protocol was used to image a flank SKOV3 tumor model. Bloch fitting modified to include the direct estimation of pH was developed to generate parametric maps of tumor pHe in the SKOV3 tumor model, a patient with high-grade invasive ductal carcinoma, and a patient with metastatic ovarian cancer...
November 28, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27888530/perturbation-of-longitudinal-relaxation-rate-in-rotating-frame-plrf-analysis-for-quantification-of-chemical-exchange-saturation-transfer-signal-in-a-transient-state
#12
Yi Wang, Yaoyu Zhang, Xuna Zhao, Bing Wu, Jia-Hong Gao
PURPOSE: To develop a novel analytical method for quantification of chemical exchange saturation transfer (CEST) in the transient state. The proposed method aims to reduce the effects of non-chemical-exchange (non-CE) parameters on the CEST signal, emphasizing the effect of chemical exchange. METHODS: The difference in the longitudinal relaxation rate in the rotating frame ( ΔR1ρ) was calculated based on perturbation of the Z-value by R1ρ, and a saturation-pulse-amplitude-compensated exchange-dependent relaxation rate (SPACER) was determined with a high-exchange-rate approximation...
November 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27859838/aggregation-induced-changes-in-the-chemical-exchange-saturation-transfer-cest-signals-of-proteins
#13
Steffen Goerke, Katharina S Milde, Raul Bukowiecki, Patrick Kunz, Karel D Klika, Thomas Wiglenda, Axel Mogk, Erich E Wanker, Bernd Bukau, Mark E Ladd, Peter Bachert, Moritz Zaiss
Chemical exchange saturation transfer (CEST) is an MRI technique that allows mapping of biomolecules (small metabolites, proteins) with nearly the sensitivity of conventional water proton MRI. In living organisms, several tissue-specific CEST effects have been observed and successfully applied to diagnostic imaging. In these studies, particularly the signals of proteins showed a distinct correlation with pathological changes. However, as CEST effects depend on various properties that determine and affect the chemical exchange processes, the origins of the observed signal changes remain to be understood...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27816001/diamagnetic-chemical-exchange-saturation-transfer-diacest-affords-magnetic-resonance-imaging-of-extracellular-matrix-hydrogel-implantation-in-a-rat-model-of-stroke
#14
Tao Jin, Francesca J Nicholls, William R Crum, Harmanvir Ghuman, Stephen F Badylak, Michel Modo
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics of the ECM material after implantation and its biodegradation over time. We describe the use of diamagnetic chemical exchange saturation transfer (CEST) magnetic resonance imaging to monitor the distribution of an ECM hydrogel after intracerebral implantation into a stroke cavity...
January 2017: Biomaterials
https://www.readbyqxmd.com/read/27812541/muscle-oxidative-phosphorylation-quantitation-using-creatine-chemical-exchange-saturation-transfer-crcest-mri-in-mitochondrial-disorders
#15
Catherine DeBrosse, Ravi Prakash Reddy Nanga, Neil Wilson, Kevin D'Aquilla, Mark Elliott, Hari Hariharan, Felicia Yan, Kristin Wade, Sara Nguyen, Diana Worsley, Chevonne Parris-Skeete, Elizabeth McCormick, Rui Xiao, Zuela Zolkipli Cunningham, Lauren Fishbein, Katherine L Nathanson, David R Lynch, Virginia A Stallings, Marc Yudkoff, Marni J Falk, Ravinder Reddy, Shana E McCormack
Systemic mitochondrial energy deficiency is implicated in the pathophysiology of many age-related human diseases. Currently available tools to estimate mitochondrial oxidative phosphorylation (OXPHOS) capacity in skeletal muscle in vivo lack high anatomic resolution. Muscle groups vary with respect to their contractile and metabolic properties. Therefore, muscle group-specific estimates of OXPHOS would be advantageous. To address this need, a noninvasive creatine chemical exchange saturation transfer (CrCEST) MRI technique has recently been developed, which provides a measure of free creatine...
November 3, 2016: JCI Insight
https://www.readbyqxmd.com/read/27805423/the-potential-of-multiparametric-mri-of-the-breast
#16
Katja Pinker, Thomas H Helbich, Elizabeth A Morris
MRI is an essential tool in breast imaging, with multiple established indications. Dynamic contrast-enhanced MRI (DCE-MRI) is the backbone of any breast MRI protocol and has an excellent sensitivity and good specificity for breast cancer diagnosis. DCE-MRI provides high-resolution morphological information, as well as some functional information about neoangiogenesis as a tumour-specific feature. To overcome limitations in specificity, several other functional MRI parameters have been investigated and the application of these combined parameters is defined as multiparametric MRI (mpMRI) of the breast...
January 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/27748713/cellular-and-molecular-imaging-using-chemical-exchange-saturation-transfer
#17
Michael T McMahon, Assaf A Gilad
Chemical exchange saturation transfer (CEST) is a powerful new tool well suited for molecular imaging. This technology enables the detection of low concentration probes through selective labeling of rapidly exchanging protons or other spins on the probes. In this review, we will highlight the unique features of CEST imaging technology and describe the different types of CEST agents that are suited for molecular imaging studies, including CEST theranostic agents, CEST reporter genes, and CEST environmental sensors...
October 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27747879/invited-commentary-mapping-the-alteration-in-glutamate-with-glucest-mri-in-a-mouse-model-of-dopamine-deficiency-an-editorial-highlight-for-mapping-the-alterations-in-glutamate-with-glucest-mri-in-a-mouse-model-of-dopamine-deficiency
#18
Paul Cumming, Jürgen Gallinat
Read the highlighted article 'Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency' on page 432.
November 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27742110/interrogating-metabolism-in-brain-cancer
#19
REVIEW
Travis C Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth T Gammon, Frederick F Lang, Amy B Heimberger, Pratip K Bhattacharya
This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved...
November 2016: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27717216/simulation-phantom-validation-and-clinical-evaluation-of-fast-ph-weighted-molecular-imaging-using-amine-chemical-exchange-saturation-transfer-echo-planar-imaging-cest-epi-in-glioma-at-3%C3%A2-t
#20
Robert J Harris, Timothy F Cloughesy, Linda M Liau, Phioanh L Nghiemphu, Albert Lai, Whitney B Pope, Benjamin M Ellingson
Acidity within the extracellular milieu is a hallmark of cancer. There is a current need for fast, high spatial resolution pH imaging techniques for clinical evaluation of cancers, including gliomas. Chemical exchange saturation transfer (CEST) MRI targeting fast-exchanging amine protons can be used to obtain high-resolution pH-weighted images, but conventional CEST acquisition strategies are slow. There is also a need for more accurate MR simulations to better understand the effects of amine CEST pulse sequence parameters on pH-weighted image contrast...
November 2016: NMR in Biomedicine
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