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Proximal hypospadias

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https://www.readbyqxmd.com/read/29332064/recurrent-intragenic-duplication-within-the-nr5a1-gene-and-severe-proximal-hypospadias
#1
Matthieu Peycelon, Lamisse Mansour-Hendili, Capucine Hyon, Nathalie Collot, Muriel Houang, Marie Legendre, Maud Chabaud, Marie-Dominique Bouvier, Georges Audry, Serge Amselem, Jean-Pierre Siffroi
A heterozygous intragenic duplication within the repeated area (CTGCAGCTG)×2 of the NR5A1 gene was found in a 15-year-old 46,XY DSD (disorders/differences of sex development) patient with micropenis and severe proximal hypospadias. This heterozygous duplication has already been described twice in boys with a similar phenotype, whereas a deletion of 3 amino acids at the same position in the protein SF-1 has been described in a 46,XX patient with primary ovarian failure and short stature. These data suggest that this region within the NR5A1 gene has an important role for SF-1 protein function in gonads and is a hotspot for intragenic rearrangements...
January 13, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/29323065/emerging-role-of-preputial-vascular-pattern-and-postoperative-microvessel-density-in-cases-of-proximal-hypospadias-a-pilot-study
#2
Vishrut Narang, Amita Sen, Minakshi Bhardwaj
INTRODUCTION: Understanding of anatomical vascular patterns and anatomy of prepuce is critical for a good outcome in hypospadias surgery. A well-vascularized neourethral and preputial flaps used for repair are exceptionally important for a successful outcome, especially in cases of proximal hypospadias undergoing one-stage procedures. OBJECTIVE: To evaluate the vascular anatomy of prepuce in cases of proximal hypospadias and to evaluate microvessel density (MVD) by immunohistochemistry and its correlation with postoperative complications...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29247355/optimisation-of-sonourethrography-the-clamp-method
#3
Juan de Dios Berná-Mestre, Thierry Balmaceda, Diego Martínez, Jose F Escudero, Gloria Martínez, José A García, Manuel Canteras, Juan D Berná-Serna
PURPOSE: To describe the clamp method for performing retrograde sonourethrography (RSUG) and contrast-enhanced voiding sonourethrography (CE-VSUG) via the transperineal approach in male adults. MATERIALS AND METHODS: Prospective study of 113 males (14-86 years) with urethral strictures confirmed by urethrography who received sonourethrography via the clamp method between 2011 and 2015. The characteristic parameters of the quantitative variables were calculated and a comparative analysis of the qualitative variables was conducted using the McNemar test...
December 15, 2017: European Radiology
https://www.readbyqxmd.com/read/29234534/comparison-of-interrupted-and-continuous-suture-urethroplasty-in-tubularised-incised-plate-hypospadias-repair-a-prospective-study
#4
Archika Gupta, Rajesh Gupta, Punit Srivastav, Ankush Gupta
Objective: To compare the effect of interrupted- and continuous-suture urethroplasty on complication rates in Snodgrass tubularised incised-plate (TIP) hypospadias repair. Patients and methods: This was a prospective randomised study comprising 100 boys (age range 1-5 years) with primary subcoronal, distal- and mid-penile hypospadias who underwent repair from October 2010 to March 2015 in a tertiary care hospital. Boys with glanular, recurrent, and proximal hypospadias were excluded from the study...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29201519/glans-wings-are-separated-ventrally-by-the-septum-glandis-and-frenulum-penis-mri-documentation-and-surgical-implications
#5
Hüseyin Özbey, Ali Kumbasar
Objective: In the normal human penis, the glans wings are in apposition in the midline ventrally, and are separated by the "septum glandis" and "frenulum" of the prepuce. However, most of the hypospadias repair techniques include dissection of the glans wings and their approximation enclosing the neourethra within the glans. Material and methods: In order to obtain detailed information about the normal anatomy of glans penis, magnetic resonance imaging (MRI) findings of the penis were studied in three adults...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29183664/distal-urethral-plate-adhesions-new-anatomical-perspective-in-hypospadias
#6
Marcel Drlík, Radim Kočvara, Josef Sedláček, Zdeněk Dítě, Ivana Vítková, Martin Komarc
INTRODUCTION: We found midline epithelial adhesions in the glandar urethral plate in patients with hypospadias. After dissolution, a blind epithelized channel becomes visualized inside of the plate pointing to immature embryonic luminization. In addition it reveals that the epithelized surface of the distal urethral plate is larger than previously considered. OBJECTIVE: To determine the incidence and extent of these new anatomical details of urethral plate in hypospadias patients...
November 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29174377/testosterone-prior-to-hypospadias-repair-postoperative-complication-rates-and-long-term-cosmetic-results-penile-length-and-body-height
#7
S P Rynja, T P V M de Jong, J L H R Bosch, L M O de Kort
INTRODUCTION: The use of hormonal therapy was first described in 1971 before hypospadias surgery, and it has been debated ever since. The long-term outcomes after puberty of patients treated with pre-operative testosterone in childhood are lacking. OBJECTIVES: Possible long-term effects of testosterone are often asked about in daily practice. The current study investigated the long-term outcomes regarding height, penile length and penile cosmesis in adult men after hypospadias surgery in childhood with and without pre-operative testosterone...
October 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29155192/external-genital-development-urethra-formation-and-hypospadias-induction-in-guinea-pig-a-double-zipper-model-for-human-urethral-development
#8
Shanshan Wang, Mingxin Shi, Dongqing Zhu, Ranjiv Mathews, Zhengui Zheng
OBJECTIVES: To determine whether the guinea pig phallus would be an appropriate model of human penile development, we characterized the embryology and sexual differentiation of guinea pig external genitalia and attend to induce hypospadias in males and tubular urethra formation in females pharmacologically. MATERIALS AND METHODS: The external genitalia of guinea pig were collected from genital swelling initiation to newborn stages and Scanning Electronic Microscopy and histology were performed to visualize the morphology and structure...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29155191/ultrasound-guided-pudendal-block-is-a-viable-alternative-to-caudal-block-for-hypospadias-surgery-a-single-surgeon-pilot-study
#9
Sarah Hecht, Jorge Piñeda, Aaron Bayne
OBJECTIVE: To evaluate pudendal nerve block as an alternative to caudal block for hypospadias surgery. METHODS: Data were obtained by chart review. Children who underwent hypospadias repair between 2012 and 2016 by a single surgeon at an academic institution were included. Patients received ultrasound-guided pudendal block (n=21) or caudal block (n=19) as a regional adjunct to general anesthesia. Primary outcomes included analgesic requirement and postoperative length of stay in the recovery unit...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29144927/re-can-separation-of-the-scrotal-sac-in-proximal-hypospadias-reliably-predict-the-need-for-urethral-plate-transection
#10
Douglas A Canning
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29135145/-aesthetic-criteria-in-surgical-treatment-of-hypospadias-in-children
#11
G V Kozyrev, A A Protasov, V V Nikolaev, F K Abdullaev, G A Abdulkarimov, M E Karmanov
Aesthetically acceptable cosmetic results of surgical correction of external genital organ defects are important for treatment evaluation along with well-known criteria of good functional outcomes.The purpose of this study was to improve the results of treating children with hypospadias by improving the assessment of results and introducing multi-step correction modalities. MATERIALS AND METHODS: From 2013 to 2015, 476 patients with various forms of hypospadias were treated at the Department of Uroandrology of RCCH...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29133164/pre-incision-urethral-plate-width-does-not-impact-short-term-tubularized-incised-plate-urethroplasty-outcomes
#12
N C Bush, W Snodgrass
INTRODUCTION: Two reports have found that urethral plate (UP) widths <8 mm before tubularized incised plate (TIP) incision increased urethroplasty complications. The present study measured pre-incision UP width in consecutive boys undergoing TIP to determine if it affected outcomes. METHODS: The present study followed the method previously used by Holland and Smith, and Sarhan et al. to measure UP width before creating glans wings or performing midline plate incision in consecutive patients with primary hypospadias and ventral curvature <30°, who all underwent TIP repair (Summary Fig...
June 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29061174/de-novo-chromosome-7q36-1q36-2-triplication-in-a-child-with-developmental-delay-growth-failure-distinctive-facial-features-and-multiple-congenital-anomalies-a-case-report
#13
Muna A Al Dhaibani, Diane Allingham-Hawkins, Ayman W El-Hattab
BACKGROUND: Studying human genome using chromosomal microarrays has significantly improved the accuracy and yield of diagnosing genomic disorders. Chromosome 7q36 deletions and duplications are rare genomic disorders that have been reported in a limited number of children with developmental delay, growth retardation, and congenital malformation. Altered dosage of SHH and HLXB9, both located in 7q36.3, is believed to play roles in the phenotypes associated with these rearrangements. In this report we describe a child with 7q36...
October 23, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29043694/-long-term-results-of-hypospadias-surgery-urinary-and-sexual-function-and-psychological-impact
#14
J Rojas-Ticona, G Zambudio Carmona, L Delmas Benito, M Fernández-Ibieta, P Y Reyes Ríos, I Martínez Castaño, V Villamil, A Sánchez Sánchez, M J Guirao Piñera, J I Ruiz Jiménez
OBJECTIVES: To determine the current status of the patients operated on for hypospadias in our region, in order to adapt the surgical technique to their real needs. MATERIAL AND METHODS: A descriptive and observational study. Interviews were conducted with hypospadias surgery patients in our hospital between 1976 and 1996, focusing on their urinary and sexual function and psychological impact. We performed a descriptive statistical analysis and comparisons between types of hypospadias (SPSSv19)...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29039059/modified-tubularized-incised-plate-urethroplasty-reduces-the-risk-of-fistula-and-meatal-stenosis-for-proximal-hypospadias-a-report-of-63-cases
#15
Hamid Arshadi, Shabnam Sabetkish, Abdol-Mohammad Kajbafzadeh
PURPOSE: To report the feasibility of modified tubularized incised plate (TIP) urethroplasty technique for proximal hypospadias in 63 cases. METHODS: From January 2004 to March 2010, 63 patients underwent one-stage TIP urethroplasty (modified Snodgrass technique repair) using 2-3 of three covering layers (corpus spongiosum, dartos, and tunica vaginalis). The primary meatus was proximal penile, penoscrotal, scrotal, and perineal in 38, 13, 10, and 2 patients, respectively...
December 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28976350/comparison-of-tubularized-incised-plate-urethroplasty-and-onlay-island-flap-urethroplasty-techniques-in-the-repair-of-primarily-proximal-hypospadias
#16
Yasin Aydogmus, Sahin Bagbanci, Arif Demirbas, Ahmet Metin Hascicek
OBJECTIVES: To compare the success of the 'tubularized incised plate urethroplasty' (TIPU) and 'Onlay island flap urethroplasty' (OIFU) techniques for the repair of primary proximal hypospadias. MATERIAL AND METHODS: A retrospective evaluation was made of the medical records of 68 patients with primary, non-complicated hypospadias, who were operated on in the Department of Urology, Ministry of Health Ankara Education and Research Hospital, between January 1997 and December 2012...
October 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28917023/a-new-modification-of-the-duckett-technique-for-one-stage-repairing-urethral-plate-transected-hypospadias-another-option-for-severe-hypospadias
#17
Li-Qu Huang, Yun-Fei Guo, Zheng Ge, Ru-Gang Lu, Yong-Ji Deng, Geng Ma, Fang Chen
OBJECTIVES: The study aimed to evaluate the new modification of the Duckett technique in decreasing the incidence of urethral strictures for urethral plate transected hypospadias and also explored its clinical application. METHODS: Thirty-three patients (aged 7 months to 12 years, mean age 2.8 years) who underwent repair of primary hypospadias using the new one-stage urethroplasty were enrolled. Clinical data, including cosmetic and its complications, and uroflowmetry data were documented...
December 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28901936/advances-in-paediatric-urology
#18
REVIEW
David A Diamond, Ivy H Y Chan, Andrew J A Holland, Michael P Kurtz, Caleb Nelson, Carlos R Estrada, Stuart Bauer, Paul K H Tam
Paediatric urological surgery is often required for managing congenital and acquired disorders of the genitourinary system. In this Series paper, we highlight advances in the surgical management of six paediatric urological disorders. The management of vesicoureteral reflux is evolving, with advocacy ranging from a less interventional assessment and antimicrobial prophylaxis to surgery including endoscopic injection of a bulking agent and minimally invasive ureteric reimplantation. Evidence supports early orchidopexy to improve fertility and reduce malignancy in boys with undescended testes...
September 9, 2017: Lancet
https://www.readbyqxmd.com/read/28738760/substitution-urethroplasty-for-anterior-urethral-stricture-repair-comparison-between-lingual-mucosa-graft-and-pedicled-skin-flap
#19
Qiang Fu, Yumeng Zhang, Jiong Zhang, Hong Xie, Ying-Long Sa, Sanbao Jin
OBJECTIVES: The aim of this study was to compare the effectiveness and outcomes of lingual mucosa graft (LMG) urethroplasty versus pedicled skin flap (PSF) urethroplasty in the repair of anterior urethral strictures. MATERIALS AND METHODS: A retrospective study in one urological center examined 293 male patients with anterior urethral strictures who received substitution urethroplasty from 2006 to 2015. Of these, 199 patients received PSF urethroplasty and 94 received LMG urethroplasty...
July 25, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28694573/two-stages-repair-of-proximal-hypospadias-review-of-700-cases
#20
Arvind Kumar Shukla, Aditya Pratap Singh, Pramila Sharma, Jyotsna Shukla
OBJECTIVE: Surgical repair of hypospadias is challenging and problematic even for the most experienced specialists, and this is especially true when severe and complicated case is confronted. Many operations had been described for the management of this deformity. MATERIALS AND METHODS: During the period from May 2004 to December 2015, we performed 700 cases with proximal hypospadias, at our institute in the Department of Pediatric Surgery by a single surgeon. Data were collected retrospectively and included patient's age at operation, degree of the hypospadias, degree of associated chordee, complications, and cosmetic outcome...
July 2017: Journal of Indian Association of Pediatric Surgeons
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