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https://www.readbyqxmd.com/read/27873263/effects-of-volume-resuscitation-on-the-microcirculation-in-animal-models-of-lipopolysaccharide-sepsis-a-systematic-review
#1
REVIEW
Nchafatso G Obonyo, Jonathon P Fanning, Angela S Y Ng, Leticia P Pimenta, Kiran Shekar, David G Platts, Kathryn Maitland, John F Fraser
BACKGROUND: Recent research has identified an increased rate of mortality associated with fluid bolus therapy for severe sepsis and septic shock, but the mechanisms are still not well understood. Fluid resuscitation therapy administered for sepsis and septic shock targets restoration of the macro-circulation, but the pathogenesis of sepsis is complex and includes microcirculatory dysfunction. OBJECTIVE: The objective of the study is to systematically review data comparing the effects of different types of fluid resuscitation on the microcirculation in clinically relevant animal models of lipopolysaccharide-induced sepsis...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27703980/advanced-hemodynamic-management-in-patients-with-septic-shock
#2
Bernd Saugel, Wolfgang Huber, Axel Nierhaus, Stefan Kluge, Daniel A Reuter, Julia Y Wagner
In patients with sepsis and septic shock, the hemodynamic management in both early and later phases of these "organ dysfunction syndromes" is a key therapeutic component. It needs, however, to be differentiated between "early goal-directed therapy" (EGDT) as proposed for the first 6 hours of emergency department treatment by Rivers et al. in 2001 and "hemodynamic management" using advanced hemodynamic monitoring in the intensive care unit (ICU). Recent large trials demonstrated that nowadays protocolized EGDT does not seem to be superior to "usual care" in terms of a reduction in mortality in emergency department patients with early identified septic shock who promptly receive antibiotic therapy and fluid resuscitation...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27604184/high-reliability-pediatric-septic-shock-quality-improvement-initiative-and-decreasing-mortality
#3
Roni D Lane, Tomohiko Funai, Ron Reeder, Gitte Y Larsen
BACKGROUND AND OBJECTIVE: Septic shock impacts mortality, morbidity, and health care costs. A quality improvement (QI) initiative was launched to improve early recognition and timely treatment of patients with septic shock in a pediatric emergency department (PED). Our primary aim was to describe the longitudinal effectiveness of the program, iterative changes in clinical practice, and associated outcomes. METHODS: We implemented multiple interventions during our QI initiative (February 2007 to December 2014)...
September 7, 2016: Pediatrics
https://www.readbyqxmd.com/read/27586973/-venous-to-arterial-carbon-dioxide-difference-to-arteriovenous-oxygen-content-difference-ratio-combined-with-lactate-to-predict-prognosis-of-patients-with-septic-shock
#4
S J Gong, J Song, J D Zhou, Y H Yu, H W Dai, M J Wang, L Li, Q H Xu, J Yan
OBJECTIVE: To investigate the prognostic significance of venous-to-arterial carbon dioxide difference to arteriovenous oxygen content difference ratio (Pv-aCO2/Ca-vO2 ratio) combined with lactate in patients with septic shock during the early phases of resuscitation. METHODS: A retrospective study was conducted for 104 septic shock patients. All patients received an initial fluid resuscitation according to the Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012(SSC2012)...
September 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27500722/treatment-of-pediatric-septic-shock-with-the-surviving-sepsis-campaign-guidelines-and-picu-patient-outcomes
#5
Jennifer K Workman, Stefanie G Ames, Ron W Reeder, E Kent Korgenski, Susan M Masotti, Susan L Bratton, Gitte Y Larsen
OBJECTIVES: The Surviving Sepsis Campaign recommends rapid recognition and treatment of severe sepsis and septic shock. Few reports have evaluated the impact of these recommendations in pediatrics. We sought to determine if outcomes in patients who received initial care compliant with the Surviving Sepsis Campaign time goals differed from those treated more slowly. DESIGN: Single center retrospective cohort study. SETTING: Emergency department and PICU at an academic children's hospital...
October 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27467907/incidence-predictors-and-outcomes-of-new-onset-atrial-fibrillation-in-critically-ill-patients-with-sepsis-a-cohort-study
#6
Peter M C Klein Klouwenberg, Jos F Frencken, Sanne Kuipers, David S Y Ong, Linda M Peelen, Lonneke A van Vught, Marcus J Schultz, Tom van der Poll, Marc J Bonten, Olaf L Cremer
RATIONALE: Patients admitted to intensive care units with sepsis are prone to developing cardiac dysrhythmias, most commonly atrial fibrillation. OBJECTIVES: We determined the incidence, risk factors and outcomes of atrial fibrillation in a cohort of critically ill patients with sepsis. METHODS: We assessed the association between atrial fibrillation and mortality using time-dependent competing risks survival analysis. Subsequently, for development of a risk score estimating the probability of a first occurrence of atrial fibrillation within the following 24 hours, we performed logistic regression analysis...
July 28, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27464633/-advances-in-the-research-of-effects-of-cholinergic-anti-inflammatory-pathway-on-vital-organ-function-and-its-mechanism
#7
X H Li, Y M Yao
Serious major burns, trauma and surgical stress can easily develop into sepsis, and further result in septic shock or even multiple organ dysfunction syndrome (MODS). The mechanism of MODS is complicated, including excessive inflammation, immune dysfunction, coagulation disorder, and ischemia-reperfusion injury. Recent studies have demonstrated that the nervous system could significantly and quickly suppress systemic inflammatory response via the vagus nerve, which might improve multiple organ damage following acute injury...
July 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27355401/beneficial-effect-of-intermedin-1-53-in-septic-shock-rats-contributions-of-rho-kinase-and-bkca-pathway-mediated-improvement-in-cardiac-function
#8
Tao Li, Zhu Yu, Wu Huiling, Wu Yue, Zhang Jie, Peng Xiaoyong, Zang Jiatao, Xiang Xinming, Liangming Liu
OBJECTIVE: Intermedin (IMD) is a calcitonin gene-related peptide shown to have a protective effect on myocardial function in ischemia-reperfusion injury. Whether IMD has beneficial effect in severe sepsis and septic shock (and its underlying mechanisms) is not known. METHODS: We induced septic shock using cecal ligation and puncture (CLP). We focused on the potential beneficial effect of IMD1-53 on cardiac papillary muscle and cardiomyocytes against septic shock and its relationship with protection of cardiac function...
June 28, 2016: Shock
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#9
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27303750/phenotypes-and-virulence-among-staphylococcus-aureus-usa100-usa200-usa300-usa400-and-usa600-clonal-lineages
#10
Jessica M King, Katarina Kulhankova, Christopher S Stach, Bao G Vu, Wilmara Salgado-Pabón
Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. However, the virulence mechanisms associated with these clonal lineages, in particular the USA100 and USA600 isolates, have been severely understudied. We investigated the virulence of these strains, in addition to strains in the USA200, USA300, and USA400 types, in well-established in vitro assays and in vivo in the rabbit model of infective endocarditis and sepsis...
May 2016: MSphere
https://www.readbyqxmd.com/read/27290486/different-hemoglobin-thresholds-for-transfusion-in-patients-with-severe-sepsis-and-septic-shock
#11
T Kamio, M Sanui, M Hayakawa, D Kudo, K Yamakawa, Y Iizuka, S Saito, K Takimoto, S Uchino, T Mayumi, Y Sasabuchi
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290471/underweight-is-associated-with-mortality-in-patients-with-severe-sepsis-and-septic-shock
#12
S M Lee, J W Kang, Y H Jo, K Kim, J H Lee, J Lee, K P Rim
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290399/the-effect-of-endotoxin-adsorber-hemoperfusion-on-microcirculation-in-patients-with-severe-sepsis-and-septic-shock
#13
Y-C Yeh, Y-C Hsu, A Chao, V-C Wu, W-H Sheng, C-C Kao, Y-J Cheng
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290024/the-effect-of-early-goal-directed-therapy-on-outcome-in-adult-severe-sepsis-and-septic-shock-patients-a-meta-analysis-of-randomised-clinical-trials
#14
J Xu, Y Yang, H Qiu
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27289984/low-dose-immunoglobulin-g-for-treatment-of-severe-sepsis-and-septic-shock
#15
Y Iizuka, M Sanui, M Hayakawa, S Uchino, T Mayumi, D Kudo, S Saito, K Takimoto, K Yamakawa, Y Sasabuchi
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27261276/lipopolysaccharide-induced-cd300b-receptor-binding-to-toll-like-receptor-4-alters-signaling-to-drive-cytokine-responses-that-enhance-septic-shock
#16
Oliver H Voss, Yousuke Murakami, Mirna Y Pena, Ha-Na Lee, Linjie Tian, David H Margulies, Jonathan M Street, Peter S T Yuen, Chen-Feng Qi, Konrad Krzewski, John E Coligan
Receptor CD300b is implicated in regulating the immune response to bacterial infection by an unknown mechanism. Here, we identified CD300b as a lipopolysaccharide (LPS)-binding receptor and determined the mechanism underlying CD300b augmentation of septic shock. In vivo depletion and adoptive transfer studies identified CD300b-expressing macrophages as the key cell type augmenting sepsis. We showed that CD300b, and its adaptor DAP12, associated with Toll-like receptor 4 (TLR4) upon LPS binding, thereby enhancing TLR4-adaptor MyD88- and TRIF-dependent signaling that resulted in an elevated pro-inflammatory cytokine storm...
June 21, 2016: Immunity
https://www.readbyqxmd.com/read/27256603/-the-echocardiographic-evaluation-and-its-predicted-prognosis-of-acute-left-cardiac-systolic-dysfunction-in-critically-ill-patients
#17
X T Wang, H Zhao, D W Liu, H M Zhang, Y Long, W Z Chai, Q Zhang
OBJECTIVE: The purpose of this study was to evaluate the significance of echocardiography for the prognosis of acute left cardiac dysfunction in critically ill patients. METHODS: A prospective cohort study was conducted in patients with acute left cardiac dysfunction in the Department of Critical Care Medicine, Peking Union Medical College Hospital from June 2013 to June 2014. Patients were divided into four groups according to the echocardiographic manifestation, including biventricular failure, left ventricular failure, coronary related segmental movement disorder, non-coronary related segmental movement disorder...
June 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27234777/heart-transplantation-under-mechanical-circulatory-support-for-acute-fulminant-myocarditis-with-cardiogenic-shock-10%C3%A2-years-experience-of-a-single-center
#18
M Ting, C-H Wang, C-I Tsao, S-C Huang, N-H Chi, N-K Chou, Y-S Chen, S-S Wang
BACKGROUND: Acute fulminant myocarditis with intractable cardiogenic shock is a fatal condition; its only therapeutic option is mechanical circulatory support. The use of mechanical circulatory support, either extracorporeal membrane oxygenation (ECMO) or a ventricular assist device (VAD), serves as a bridge to recovery or as a bridge to transplantation. OBJECTIVES: The aim of this research was to advance our understanding of the outcome of heart transplantation under mechanical support for acute myocarditis...
April 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27209081/penetrating-pelvic-trauma-initial-assessment-and-surgical-management-in-emergency
#19
E Hornez, T Monchal, G Boddaert, P Chiron, J Danis, Y Baudoin, J-L Daban, P Balandraud, S Bonnet
Penetrating pelvic trauma (PPT) is defined as a wound extending within the bony confines of the pelvis to involve the vascular, intestinal or urinary pelvic organs. The gravity of PPT is related to initial hemorrhage and the high risk of late infection. If the patient is hemodynamically unstable and in hemorrhagic shock, the urgent treatment goal is rapid achievement of hemostasis. Initial strategy relies on insertion of an intra-aortic occlusion balloon and/or extraperitoneal pelvic packing, performed while damage control resuscitation is ongoing before proceeding to arteriography...
August 2016: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/27200381/weathering-a-cytokine-storm-a-case-of-ebv-induced-hemophagocytic-lymphohistiocytosis
#20
Tiffany Y Shaw, Michael Schivo
Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening disease caused by excessive immune activation. Acquired HLH is seen in adults and is often caused by infection or malignancy. Diagnosis is difficult and usually missed as clinical and laboratory findings are nonspecific. Moreover, the pathophysiology of the systemic inflammatory response syndrome and/or sepsis is remarkably similar to HLH. Thus, in patients presenting with presumed severe sepsis or septic shock complicated by multiorgan failure without a clear infectious source, HLH should be considered...
April 2016: Journal of Investigative Medicine High Impact Case Reports
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