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Citrulline AND NO

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https://www.readbyqxmd.com/read/29900983/relationship-between-smoking-and-structural-damage-autoimmune-antibodies-and-disability-in-rheumatoid-arthritis-patients
#1
Filiz Sivas, Fatma Gül Yurdakul, Ayşegül Kiliçarslan, Semra Duran, Bedriye Başkan, Hatice Bodur
Objectives: This study aims to investigate the relationship between smoking and structural damage, autoimmune antibodies, and disability in rheumatoid arthritis (RA) patients. Patients and methods: This cross-sectional study included 165 RA patients (36 males, 129 females; mean age 52.4±12.8 years; range 21 to 82 years). Disease duration, age at disease onset, smoking habits, rheumatoid factor (RF), and anti-cyclic citrullinated peptide levels were recorded. Morning stiffness, pain with visual analog scale, Health Assessment Questionnaire Scores And Disease Activity Score 28 were calculated...
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29900970/the-association-of-anti-aminoacyl-transfer-ribonucleic-acid-synthetase-antibodies-in-patients-with-rheumatoid-arthritis-and-interstitial-lung-disease
#2
Masakazu Matsushita, Naoto Tamura, Michihiro Ogasawara, Kurisu Tada, Ken Yamaji, Yoshinari Takasaki
Objectives: This study aims to analyze the distribution and clinicopathological characteristics of anti-aminoacyl-transfer ribonucleic acid (tRNA) synthetase (ARS) antibodies in rheumatoid arthritis patients. Patients and methods: We retrospectively studied the anti-ARS antibody levels in 228 RA patients' (44 males, 184 females; mean age 62.9±14.0 years; range 23 to 88 years) sera from their medical charts. We determined the association with anti-cyclic citrullinated peptide antibody levels, interstitial lung disease (ILD), rheumatoid factor, and methotrexate or biological disease modifying antirheumatic drug treatments...
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29900030/primary-solitary-retro-clival-amyloidoma
#3
Julia R Schneider, Kevin Kwan, Kay O Kulason, Lukas J Faltings, Stephanie Colantonio, Scott Safir, Tina Loven, Jian Yi Li, Karen S Black, B Todd Schaeffer, Mark B Eisenberg
Background: Amyloidosis encompasses a group of disorders sharing the common feature of intercellular deposition of amyloid protein by several different pathogenetic mechanisms. Primary solitary amyloidosis, or amyloidoma, is a rare subset of amyloidosis in which amyloid deposition is focal and not secondary to a systemic process or plasma cell dyscrasia. Case Description: This 84-year-old female presented with history of multiple syncopal episodes, dysphagia, and ataxia...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29896200/protein-deiminase-4-and-cr3-regulate-aspergillus-fumigatus-and-%C3%AE-glucan-induced-neutrophil-extracellular-trap-formation-but-hyphal-killing-is-dependent-only-on-cr3
#4
Heather L Clark, Serena Abbondante, Martin S Minns, Elyse N Greenberg, Yan Sun, Eric Pearlman
Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone citrullination. In the current study, we examined the role of PAD4 and NETosis following activation of neutrophils by A. fumigatus hyphal extract or cell wall β-glucan (curdlan) and found that both induced NET release by human and murine neutrophils...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29895567/number-of-individual-acpa-reactivities-in-synovial-fluid-immune-complexes-but-not-serum-anti-ccp2-levels-associate-with-inflammation-and-joint-destruction-in-rheumatoid-arthritis
#5
Azita Sohrabian, Linda Mathsson-Alm, Monika Hansson, Ann Knight, Jörgen Lysholm, Martin Cornillet, Karl Skriner, Guy Serre, Anders Larsson, Tomas Weitoft, Johan Rönnelid
INTRODUCTION: Individual patients with rheumatoid arthritis (RA) show divergent specific anti-citrullinated protein/peptide antibodies (ACPA) patterns, but hitherto no individual ACPA specificity has consistently been linked to RA pathogenesis. ACPA are also implicated in immune complexes (IC)-associated joint pathology, but until now, there has been no method to investigate the role of individual ACPA in RA IC formation and IC-associated pathogenesis. METHODS: We have developed a new technique based on IC binding to C1q-coated magnetic beads to purify and solubilise circulating IC in sera and synovial fluids (SF) from 77 patients with RA...
June 12, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29894791/post-translational-modifications-of-enos-augment-nitric-oxide-availability-and-facilitates-hypoxia-adaptation-in-ladakhi-women
#6
Pooja, Dishari Ghosh, Kalpana Bhargava, Niroj Kumar Sethy
The lower inhaled oxygen per volume at high altitude poses an intimidating challenge for humans to survive and reproduce. Indigenous populations of the Himalayas reportedly exhibit higher microcirculatory blood flow accompanied by higher orders of magnitude of nitric oxide (NO) products in lung, plasma and red blood cells as a vascular adaptation strategy for hypobaric hypoxia. The precise mechanism of such observed higher NO metabolites for hypoxia adaptation remains elusive. Studying high altitude native Ladakhi women, we observed significant higher eNOS mRNA and protein in blood/plasma as compared to lowland women...
June 9, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29890305/nitric-oxide-synthase-what-is-its-potential-role-in-the-physiology-of-staphylococci-in-meat-products
#7
Geoffrey Ras, Sabine Leroy, Régine Talon
Coagulase-negative staphylococci are frequently isolated from meat products and two species are used as starter cultures in dry fermented sausages. In these products, they face various environmental conditions such as variation of redox potential and oxygen levels that can lead to oxidative stress. Furthermore, when nitrate and nitrite are added as curing salts, staphylococci also experience nitrosative stress. A nos gene encoding a nitric oxide synthase (NOS) is present in the genome of all staphylococci. NOS produces nitric oxide (NO) and citrulline from arginine, but its activity is still poorly characterized, particularly in coagulase-negative staphylococci...
June 7, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29888580/-treatment-of-rheumatoid-arthritis-by-bee-venom-acupuncture
#8
Shi-Yun Chen, Peng Zhou, Ye Qin
OBJECTIVE: To study the clinical efficacy and safety of bee-venom acupuncture therapy for rheumatoid arthritis (RA). METHODS: A total of 120 cases of RA patients were randomized into bee-sting acupuncture group (treatment) and western medicine group (control) in accordance with the random number table. The patients of the control group were treated by oral administration of Methotrexate (10 mg, once a week) and Celecoxlb (0.2 g, once a day), and those of the treatment group treated by 5 to 15 bee stings of Ashi -points or acupoints according to different conditions and corporeity, and with the bee-sting retained for about 5 min every time, once every other day...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29887621/quantitative-analysis-of-l-arginine-dimethylated-arginine-derivatives-l-citrulline-and-dimethylamine-in-human-serum-using-liquid-chromatography-mass-spectrometric-method
#9
Mariusz G Fleszar, Jerzy Wiśniewski, Małgorzata Krzystek-Korpacka, Błażej Misiak, Dorota Frydecka, Joanna Piechowicz, Katarzyna Lorenc-Kukuła, Andrzej Gamian
Nitric oxide (NO) is a small molecule involved in the regulation of many physiological processes. It plays a crucial role in the regulation of nervous system, immune and inflammatory responses, and blood flow. NO is synthesized by nitric oxide synthase (NOS) during two-step oxidation of l-arginine to l-citrulline. Intermediates and derivatives of NO metabolism, such as l-arginine, l-citrulline, asymmetrical dimethylarginine (ADMA), symmetrical dimethylarginine (SDMA), and dimethylamine (DMA), are investigated as potential biomarkers...
2018: Chromatographia
https://www.readbyqxmd.com/read/29884228/elevated-levels-of-plasma-symmetric-dimethylarginine-and-increased-arginase-activity-as-potential-indicators-of-cardiovascular-comorbidity-in-rheumatoid-arthritis
#10
Unnikrishnan M Chandrasekharan, Zeneng Wang, Yuping Wu, W H Wilson Tang, Stanley L Hazen, Sihe Wang, M Elaine Husni
BACKGROUND: Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished nitric oxide (NO) production. Because L-arginine is the sole precursor of NO, we hypothesized that levels of L-arginine metabolic products reflecting NO metabolism are altered in patients with RA. METHODS: Plasma samples from patients with RA (n = 119) and age- and sex-matched control subjects (n = 238) were used for this study...
June 8, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29881319/citrulline-improves-early-post-ischemic-recovery-or-rat-hearts-in-vitro-by-shifting-arginine-metabolism-from-polyamine-to-nitric-oxide-formation
#11
Marc Heidorn, Tim Frodermann, Andreas Böning, Rolf Schreckenberg, Klaus-Dieter Schlüter
Background: Reperfusion or reopening of occluded vessels is the gold standard to terminate ischemia. However, early functional recovery after reperfusion is often low requiring inotropic intervention. Although catecholamines increase inotropy and chronotropy, they are not the best choice because they increase myocardial oxygen and substrate demand. As nitric oxide (NO) contributes to cardiac function, we tested the hypothesis that addition of citrulline during the onset of reperfusion improves post-ischemic recovery because citrulline can reenter arginine consumption of NO synthases (NOS) but not of arginases...
2018: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/29878271/the-citrulline-recycling-pathway-sustains-cardiovascular-function-in-arginine-depleted-healthy-mice-but-cannot-sustain-nitric-oxide-production-during-endotoxin-challenge
#12
Yang Yuan, Mahmoud A Mohammad, Ancizar Betancourt, Inka C Didelija, Chandrasekar Yallampalli, Juan C Marini
Background: The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Pegylated arginine deiminase (ADI-PEG20) is a bacterial enzyme used to deplete circulating arginine. Objective: The goal of this research was to test the hypothesis that citrulline is able to sustain intracellular arginine availability for NO production in ADI-PEG20 arginine-depleted mice...
June 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29872356/serum-heat-shock-protein-65-antibody-levels-are-elevated-but-not-associated-with-disease-activity-in-patients-with-rheumatoid-arthritis-and-ankylosing-spondylitis
#13
Hasan Ulusoy, Gurkan Akgol, Arif Gulkesen, Arzu Kaya, Gul Ayden Kal, Dilara Kaman, Turkan Tuncer
Objectives: Heat-shock proteins (HSPs) have gained increased interest for their role in autoimmune disorders. These proteins are targeted by the immune system in various autoimmune diseases. The aim of this study was to assess the serum heat-shock protein-65 antibody (anti-HSP65) levels and their clinical significance in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Patients and methods: A total of 30 patients with RA, 30 patients with AS, and 30 healthy controls were enrolled in this study...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29870781/l-citrulline-restores-nitric-oxide-level-and-cellular-uptake-at-the-brain-capillary-endothelial-cell-line-tr-bbb-cells-with-glutamate-cytotoxicity
#14
Kyeong-Eun Lee, Young-Sook Kang
OBJECTIVE: Glutamate excitotoxicity provokes neuronal cell damage and death, leading to collapse of the blood-brain barrier (BBB). Recently, it has been reported that l-citrulline, a neutral amino acid and a major precursor of l-arginine in the nitric oxide (NO) cycle, can prevent both neuronal cell death and cerebrovascular cell loss in brain ischemia. Therefore, the objective of this study was to investigate the effect of l-citrulline on glutamate cytotoxicity in the BBB using the conditionally immortalized rat brain capillary endothelial cell line (TR-BBB cells) as an in vitro model of the BBB...
June 2, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29859543/accelerated-subcutaneous-nodulosis-in-patients-with-rheumatoid-arthritis-treated-with-tocilizumab-a-case-series
#15
Rossella Talotta, Fabiola Atzeni, Alberto Batticciotto, Maria Chiara Ditto, Maria Chiara Gerardi, Piercarlo Sarzi-Puttini
BACKGROUND: Tocilizumab is a monoclonal antibody directed against the interleukin-6 receptor, which is approved for the treatment of moderate-to-severe rheumatoid arthritis. Authors have found that it prevents lung and subcutaneous nodulosis in patients with rheumatoid arthritis but, to the best of our knowledge, there are no data concerning the acceleration of subcutaneous nodulosis during tocilizumab therapy. CASE PRESENTATION: We report for the first time a small case series of five patients with rheumatoid arthritis: a 46-year-old white woman, a 70-year-old white woman, a 63-year-old white woman, a 69-year-old white man, and a 72-year-old white woman (mean age 64 ± 10...
June 3, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29797700/l-citrulline-supplementation-increased-skeletal-muscle-pgc-1%C3%AE-expression-is-associated-with-exercise-performance-and-increased-skeletal-muscle-weight
#16
Myra O Villareal, Toshiya Matsukawa, Hiroko Isoda
SCOPE: L-citrulline has recently been reported as a more effective supplement for promoting intracellular NO production compared to L-arginine. Here, the effect of L-citrulline on skeletal muscle and its influence on exercise performance were investigated. The underlying mechanism of its effect, specifically on the expression of skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), was also elucidated. METHODS AND RESULTS: Six-week-old ICR mice were orally supplemented with L-citrulline (250 mg kg-1 ) daily, and their performance in weight-loaded swimming exercise every other day for 15 days, was evaluated...
May 24, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29796624/effect-of-cumulative-exposure-to-corticosteroid-and-dmard-on-radiographic-progression-in-rheumatoid-arthritis-results-from-the-espoir-cohort
#17
Baptiste Louveau, Yann De Rycke, Alexandre Lafourcade, Alain Saraux, Francis Guillemin, Florence Tubach, Bruno Fautrel, David Hajage
Objectives: Several authors have tried to predict the risk of radiographic progression in RA according to baseline characteristics, considering exposure to treatment only as a binary variable (Treated: Yes/No). This study aims to model the risk of 5-year radiographic progression taking into account both baseline characteristics and the cumulative time-varying exposure to corticosteroids or DMARDs. Methods: The study population consisted of 403 patients of the Etude et Suivi des Polyarthrites Indifférenciées Récentes cohort meeting the 1987 ACR or 2010 ACR/EULAR criteria for RA at inclusion and having complete radiographic data at baseline and 5 years...
May 22, 2018: Rheumatology
https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#18
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29773705/vapour-gas-dust-and-fume-occupational-exposures-in-male-patients-with-rheumatoid-arthritis-resident-in-cornwall-uk-and-their-association-with-rheumatoid-factor-and-anti-cyclic-protein-antibodies-a-retrospective-clinical-study
#19
Dan Murphy, Katy Bellis, David Hutchinson
OBJECTIVES: To quantify exposure to vapour, gas, dust and fumes (VGDF) and smoking in male rheumatoid arthritis (RA) and investigate impact on rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) levels. DESIGN: A retrospective observational study. SETTING: The Royal Cornwall Hospital Trust, UK. A single university hospital setting. PARTICIPANTS: 726 men followed up between February 2015 and August 2016, fulfilling RA diagnostic criteria...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29773079/effects-of-linagliptin-on-endothelial-function-and-postprandial-lipids-in-coronary-artery-disease-patients-with-early-diabetes-a-randomized-placebo-controlled-double-blind-trial
#20
Norbert J Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner, Harald Sourij
BACKGROUND: Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on a set of cardiovascular surrogate measurements...
May 17, 2018: Cardiovascular Diabetology
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