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Citrulline AND NO

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https://www.readbyqxmd.com/read/29686987/recognition-and-relevance-of-anti-dfs70-autoantibodies-in-routine-antinuclear-autoantibodies-testing-at-a-community-hospital
#1
John B Carter, Sara Carter, Sandra Saschenbrecker, Bruce E Goeckeritz
Antinuclear autoantibodies (ANA) displaying a dense fine speckled pattern (DFS, ICAP AC-2) on HEp-2 cells are frequently observed in clinical laboratory referrals, often associated with anti-DFS70 specificity. Anti-DFS70 positive patients rarely develop systemic autoimmune rheumatic disease (SARD), especially in the absence of clinical evidence or additional anti-extractable nuclear antigen (ENA) antibodies, prompting suggestions that an isolated DFS70-specific ENA may be an exclusionary finding for SARD. In this study, the frequency and diagnostic significance of anti-DFS70 autoantibodies was investigated in a community hospital cohort of patients undergoing routine ANA testing...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29684379/effect-of-a-long-term-treatment-with-metformin-in-dystrophic-mdx-mice-a-reconsideration-of-its-potential-clinical-interest-in-duchenne-muscular-dystrophy
#2
Paola Mantuano, Francesca Sanarica, Elena Conte, Maria Grazia Morgese, Roberta Francesca Capogrosso, Anna Cozzoli, Adriano Fonzino, Angelo Quaranta, Jean-Francois Rolland, Michela De Bellis, Giulia Maria Camerino, Luigia Trabace, Annamaria De Luca
The pharmacological stimulation of AMP-activated protein kinase (AMPK) via metabolic enhancers has been proposed as potential therapeutic strategy for Duchenne muscular dystrophy (DMD). Metformin, a widely-prescribed anti-hyperglycemic drug which activates AMPK via mitochondrial respiratory chain, has been recently tested in DMD patients in synergy with nitric oxide (NO)-precursors, with encouraging results. However, preclinical data supporting the use of metformin in DMD are still poor, and its actions on skeletal muscle appear controversial...
April 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29673643/use-of-gasotransmitters-for-the-controlled-release-of-polymer-based-nitric-oxide-carriers-in-medical-applications
#3
REVIEW
Chungmo Yang, Soohyun Jeong, Seul Ku, Kangwon Lee, Min Hee Park
Nitric Oxide (NO) is a small molecule gasotransmitter synthesized by nitric oxide synthase in almost all types of mammalian cells. NO is synthesized by NO synthase by conversion of l-arginine to l-citrulline in the human body. NO then stimulates soluble guanylate cyclase, from which various physiological functions are mediated in a concentration-dependent manner. High concentrations of NO induce apoptosis or antibacterial responses whereas low NO circulation leads to angiogenesis. The bidirectional effect of NO has attracted considerable attention, and efforts to deliver NO in a controlled manner, especially through polymeric carriers, has been the topic of much research...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29672788/neutrophil-extracellular-traps-participate-in-all-different-types-of-thrombotic-and-haemorrhagic-complications-of-coronary-atherosclerosis
#4
Kartika R Pertiwi, Allard C van der Wal, Dara R Pabittei, Claire Mackaaij, Marinus B van Leeuwen, Xiaofei Li, Onno J de Boer
Acute coronary syndromes can be initiated by either atherosclerotic fibrous cap ruptures, superficial plaque erosions or intraplaque haemorrhages (IPHs). Since neutrophil extracellular traps (NETs) display pro-inflammatory and pro-thrombotic properties, we investigated the presence, extent and distribution of neutrophils and NETs in different types of plaque complications in relation to the age of overlying thrombus mass or haemorrhage. Sixty-four paraffin-embedded coronary plaque segments of 30 acute myocardial infarction patients were retrieved from the autopsy archives, which contained 44 complicated plaques (17 IPHs, 9 erosions and 18 ruptures) and 20 intact plaques...
April 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29663515/determining-optimal-therapy-of-dogs-with-chronic-enteropathy-by-measurement-of-serum-citrulline
#5
Magda Gerou-Ferriani, Rhiannon Allen, Peter-John M Noble, Alexander J German, Marco Caldin, Daniel J Batchelor
BACKGROUND: Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states. OBJECTIVES: To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome. ANIMALS: Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29651749/medium-chain-triglycerides-supplement-therapy-with-a-low-carbohydrate-formula-can-supply-energy-and-enhance-ammonia-detoxification-in-the-hepatocytes-of-patients-with-adult-onset-type-ii-citrullinemia
#6
Kiyoshi Hayasaka, Chikahiko Numakura, Mitsunori Yamakawa, Tetsuo Mitsui, Hisayoshi Watanabe, Hiroaki Haga, Masahide Yazaki, Hiromasa Ohira, Yasuo Ochiai, Toshiyuki Tahara, Tamio Nakahara, Noriyo Yamashiki, Takahiro Nakayama, Takashi Kon, Hiroshi Mitsubuchi, Hiroshi Yoshida
Citrin, encoded by SLC25A13, constitutes the malate-aspartate shuttle, the main NADH-shuttle in the liver. Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2). Citrin deficiency is predicted to impair hepatic glycolysis and de novo lipogenesis, resulting in hepatic energy deficit. Secondary decrease in hepatic argininosuccinate synthetase (ASS1) expression has been considered a cause of hyperammonemia in CTLN2. We previously reported that medium-chain triglyceride (MCT) supplement therapy with a low-carbohydrate formula was effective in CTLN2 to prevent a relapse of hyperammonemic encephalopathy...
April 12, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29648475/alterations-in-plasma-l-arginine-and-methylarginines-in-heart-failure-and-after-heart-transplantation
#7
Jakob Lundgren, Anna Sandqvist, Mikael Hedeland, Ulf Bondesson, Gerhard Wikström, Göran Rådegran
OBJECTIVE: Endothelial function, including the nitric oxide (NO)-pathway, has previously been extensively investigated in heart failure (HF). In contrast, studies are lacking on the NO pathway after heart transplantation (HT). We therefore investigated substances in the NO pathway prior to and after HT in relation to hemodynamic parameters. DESIGN: 12 patients (median age 50.0 yrs, 2 females), heart transplanted between June 2012 and February 2014, evaluated at our hemodynamic lab, at rest, prior to HT, as well as four weeks and six months after HT were included...
April 12, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29624881/study-on-association-of-human-leukocyte-antigen-drb1-alleles-in-rheumatoid-arthritis-within-bangladeshi-population
#8
Maksuma Begum, Humayun Sattar, Syed A Haq, Md Nazrul Islam, Sushanta K Saha, M Masudul Hassan, Ritu Saha, Md Shahriar Kabir
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic and autoimmune disease affecting 0.5-1% of the world population. Genetic and environmental factors are already established as being involved in the development of RA. Different human leukocyte antigen (HLA)-DRB1 alleles have major pathogenic effects to the development of RA. OBJECTIVE: To determine the HLA-DRB1 allelic frequency of RA in one Bangladeshi tertiary care center. METHODS: This case-control study was conducted at the Microbiology and Rheumatology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU)...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29615411/acpa-igg-galactosylation-associates-with-disease-activity-in-pregnant-patients-with-rheumatoid-arthritis
#9
Albert Bondt, Lise Hafkenscheid, David Falck, T Martijn Kuijper, Yoann Rombouts, Johanna M W Hazes, Manfred Wuhrer, Radboud J E M Dolhain
OBJECTIVES: Patients with autoantibody-positive rheumatoid arthritis (RA) are less likely to experience pregnancy-induced improvement of RA disease activity (DAS28-C reactive protein (CRP)) compared with patients with autoantibody-negative RA. Anti-citrullinated protein antibodies (ACPAs) are the most specific autoantibodies for RA. We previously demonstrated that disease improvement is associated with changes in total IgG glycosylation, which regulate antibody effector function. Therefore, we sought to analyse the ACPA-IgG glycosylation profile during pregnancy with the aim to understand the lower change of pregnancy-induced improvement of the disease in patients with autoantibody-positive RA...
April 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29606664/rheumatoid-arthritis-magnetic-resonance-imaging-score-predicts-therapy-response-results-of-the-german-arthromark-cohort
#10
Philipp Sewerin, Lien Le, Stefan Vordenbäumen, Christoph Schleich, Ruben Sengewein, Ralph Brinks, Georg Pongratz, Ellen Bleck, Juliane Lesch, Ulrich Mansmann, Matthias Schneider, Benedikt Ostendorf
OBJECTIVE: Markers for treatment response in rheumatoid arthritis (RA) are lacking. The aim of the study was to assess the performance of the RA magnetic resonance imaging (MRI) scoring system (RAMRIS) in combination with serum biomarkers to predict response to methotrexate (MTX) treatment in therapy-naive patients with early RA by using high-field MRI. METHODS: Twenty-eight patients with RA were prospectively assessed with baseline 3-T MRI of the clinical dominant hand, 3 and 6 months after MTX...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29582894/sex-differences-in-the-associations-between-l-arginine-pathway-metabolites-skeletal-muscle-mass-and-function-and-their-responses-to-resistance-exercise-in-old-age
#11
M Da Boit, S Tommasi, D Elliot, A Zinellu, S Sotgia, R Sibson, J R Meakin, R M Aspden, C Carru, A A Mangoni, S R Gray
OBJECTIVES: The current study was designed to explore the associations between L-arginine metabolites and muscle mass and function in old age, which are largely unknown. DESIGN: The study used a randomised, double-blind, placebo-controlled design. SETTING: The study was carried out in a laboratory setting. PARTICIPANTS: 50 healthy older adults [median age 70 years (IQR 67-73); 27 males]. INTERVENTION: Participants undertook an 18-week resistance exercise program, and a nutritional intervention (fish oil vs...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29581384/ultrasound-is-more-reliable-than-inflammatory-parameters-to-evaluate-disease-activity-in-patients-with-ra-receiving-tocilizumab-therapy
#12
Wen-Chan Chiu, Han-Ming Lai, Chi-Hua Ko, Jia-Feng Chen, Chung-Yuan Hsu, Ying-Chou Chen
The target of treatment for rheumatoid arthritis (RA) is to keep low disease activity or remission. Tocilizumab can fully inhibit interleukin-6 and C reactive protein (CRP) production. The goal of the study is to search whether tocilizumab treatment compared with adalimumab treatment had the similar effect on sonography and inflammatory parameters in patients with RA. We compared ultrasound scores and inflammatory parameters between patients with RA receiving tocilizumab therapy and those receiving adalimumab therapy...
March 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29571859/plasma-citrulline-levels-are-increased-in-patients-with-multiple-sclerosis
#13
Maxime Vande Vyver, Roel Beelen, Jacques De Keyser, Guy Nagels, Anne-Marie Van Binst, Christiaan Verborgh, Miguel D'haeseleer
BACKGROUND: Multiple sclerosis is an inflammatory demyelinating disorder of the central nervous system (CNS). Myelin basic protein (MBP), which is one of the main compounds of CNS myelin, appears to be hypercitrullinated in the brain of patients with MS. We hypothesized that MS is associated with an increased release of citrulline from the brain. METHODS: Twenty-five patients with MS, 25 controls without neurological disease (CwND) and 25 subjects with non-MS cerebral white matter lesions were included in this study...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29551532/effect-of-ginger-paullinia-cupana-muira-puama-and-l-citrulline-singly-or-in-combination-on-modulation-of-the-inducible-nitric-oxide-no-cgmp-pathway-in-rat-penile-smooth-muscle-cells
#14
Monica G Ferrini, Eduardo Garcia, Andrea Abraham, Jorge N Artaza, Sabine Nguyen, Jacob Rajfer
INTRODUCTION: COMP-4 is a natural compound-based dietary supplement consisting of the combination of ginger, Paullinia cupana, muira puama and l-citrulline, which when given long-term has been shown in the aged rat to a) upregulate iNOS in the penile smooth muscle cells (SMC), b) reverse the corporal SMC apoptosis and fibrosis associated with corporal veno-occlusive dysfunction (CVOD), and c) improve resulting erectile function. To elucidate the mechanism of how COMP-4 and its individual components modulate the iNOS-cGMP pathway, an in vitro study was conducted using a rat corporal primary SMC culture to determine its effect on NOS, soluble guanylate cyclase (sGC), cGMP and the phosphodiesterase 5 enzyme (PDE5)...
March 15, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29524589/air-pollution-as-a-determinant-of-rheumatoid-arthritis
#15
Johanna Sigaux, Jérôme Biton, Emma André, Luca Semerano, Marie-Christophe Boissier
Pollution has long been incriminated in many cardiovascular and respiratory diseases. More recently, studies evaluated the potential role for particulate pollutants in autoimmune diseases, including rheumatoid arthritis (RA). The incidence of RA was found to be higher in urban areas. Living near air pollution emitters was associated with higher risks of developing RA and of producing RA-specific autoantibodies. Nevertheless, no strong epidemiological evidence exists to link one or more specific air pollution particles to RA...
March 7, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29516000/comorbidities-in-anti-cyclic-citrullinated-peptide-positive-at-risk-individuals-do-not-differ-from-those-patients-with-early-inflammatory-arthritis
#16
Sarah Twigg, Elena Nikiphorou, Jackie L Nam, Laura Hunt, Kulveer Mankia, Peta Elizabeth Pentony, Jane E Freeston, Ai Lyn Tan, Paul Emery
Objectives: To compare comorbidities in a cohort of cyclic citrullinated peptide (CCP) antibody positive patients without or prior to onset of inflammatory arthritis (IA) to those in patients with early IA. Methods: Baseline data from two established cohorts were used. The first recruited people at risk of IA: CCP antibody positive cases without IA (CCP Cohort, n  = 296). The second cohort [the Inflammatory Arthritis CONtinuum study (IACON)] recruited patients with early IA ( n  = 725)...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29505395/there-s-no-place-like-om-vesicular-sorting-and-secretion-of-the-peptidylarginine-deiminase-of-porphyromonas-gingivalis
#17
Giorgio Gabarrini, Laura M Palma Medina, Tim Stobernack, Rianne C Prins, Marines du Teil Espina, Jeroen Kuipers, Monika A Chlebowicz, John W A Rossen, Arie Jan van Winkelhoff, Jan Maarten van Dijl
The oral pathogen Porphyromonas gingivalis is one of the major periodontal agents and it has been recently hailed as a potential cause of the autoimmune disease rheumatoid arthritis. In particular, the peptidylarginine deiminase enzyme of P. gingivalis (PPAD) has been implicated in the citrullination of certain host proteins and the subsequent appearance of antibodies against citrullinated proteins, which might play a role in the etiology of rheumatoid arthritis. The aim of this study was to investigate the extracellular localization of PPAD in a large panel of clinical P...
January 1, 2018: Virulence
https://www.readbyqxmd.com/read/29505141/high-rates-of-positive-severe-combined-immunodeficiency-screening-among-newborns-with-severe-intestinal-failure
#18
Brenna S Fullerton, Cristine S Velazco, Charles R Hong, Alexandra N Carey, Tom Jaksic
PURPOSE: Severe combined immunodeficiency (SCID) screening by T-cell receptor excision circles (TREC) has been part of Massachusetts routine newborn screening since 2009. Tetratricopeptide repeat domain 7A gene (TTC7A) mutations responsible for hereditary multiple intestinal atresia with combined immunodeficiency (MIA-CID) were also recently identified. We reviewed newborn SCID screening among infants with intestinal failure and correlated results with patient characteristics and outcomes...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29503060/impact-of-3-week-citrulline-supplementation-on-postprandial-protein-metabolism-in-malnourished-older-patients-the-ciproage-randomized-controlled-trial
#19
Olivier Bouillanne, Jean-Claude Melchior, Cécile Faure, Muriel Paul, Florence Canouï-Poitrine, Yves Boirie, Didier Chevenne, Christine Forasassi, Ester Guery, Stéphane Herbaud, Philippe Le Corvoisier, Nathalie Neveux, Valérie Nivet-Antoine, Alain Astier, Agathe Raynaud-Simon, Stéphane Walrand, Luc Cynober, Christian Aussel
BACKGROUND: Citrulline (CIT), is not extracted by the splanchnic area, can stimulate muscle protein synthesis and could potentially find clinical applications in conditions involving low amino acid (AA) intake, such as in malnourished older subjects. OBJECTIVE: Our purpose was to research the effects of CIT supplementation on protein metabolism in particular on non-oxidative leucine disposal (NOLD, primary endpoint), and splanchnic extraction of amino acids in malnourished older patients...
February 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29487192/association-of-interleukin-10-gene-single-nucleotide-polymorphisms-with-rheumatoid-arthritis-in-a-chinese-population
#20
Tian-Ping Zhang, Tian-Tian Lv, Shu-Zhen Xu, Hai-Feng Pan, Dong-Qing Ye
PURPOSE OF THE STUDY: Increasing numbers of studies show that interleukin (IL)-10 plays a key role in the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA) and acts as an immunomodulatory cytokine. The purpose of the present study was to analyse the relationship between gene single nucleotide polymorphisms (SNPs) in the IL-10 gene and RA susceptibility. STUDY DESIGN: We genotyped three SNPs (rs1800890, rs3024495, rs3024505) of the IL-10 gene in a Chinese population of 354 RA patients and 367 controls...
February 27, 2018: Postgraduate Medical Journal
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