Lei Tang, Feng Qin, Deying Gong, Yu Dong, LiLi Pan, Changcui Zhou, Qinqin Yin, Xinghai Song, Rui Ling, Junlong Huang, Qin Fan, Wenhao Yi, Fengbo Wu, Xiaoai Wu, Weiyi Zhang, Jun Yang, Ji-Yu Wang
Classical local anesthetics are unsuitable to treat regional pain lasting several days due to their limited duration and systemic toxicity. Self-delivery nano systems without excipients were designed for long-term sensory blocks. 1a self-assembled into different vehicles with different fractions of intermolecular π-π stacking, transported itself into nerve cells, and released single molecules slowly to achieve long-term duration for rats' sciatic nerve block for 11.6 h in water, 12.1 h in water with CO2 and 3...
June 16, 2023: Chemical Communications: Chem Comm