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JOURNAL ARTICLE
Yan-Qin Geng, Li-Na Qiu, Yuan-Qiu Cheng, Juan-Juan Li, Yi-Lin Ma, Cheng-Cheng Zhao, Ying Cai, Xue-Bin Zhang, Jieli Chen, Yu-Chen Pan, Ke-Rang Wang, Xiu-Hua Yao, Dong-Sheng Guo, Jia-Ling Wu
Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA treatment can substantially increase blood-brain barrier (BBB) permeability and susceptibility to hemorrhagic transformation. Herein, the mechanism underlying the side effects of rtPA treatment is investigated and demonstrated that ferroptosis plays an important role. The ferroptosis inhibitor, liproxstatin-1 (Lip) is proposed to alleviate the side effects. A well-designed macrocyclic carrier, glucose-modified azocalix[4]arene (GluAC4A), is prepared to deliver Lip to the ischemic site...
April 22, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#2
JOURNAL ARTICLE
Yao Jiang, Disen Nie, Zhihao Hu, Chao Zhang, Lingdi Chang, Yu Li, Zhengxuan Li, Wei Hu, Hongji Li, Sikai Li, Chao Xu, Shaojie Liu, Fa Yang, Weihong Wen, Donghui Han, Keying Zhang, Weijun Qin
Renal cell carcinoma (RCC) is a hot tumor infiltrated by large numbers of CD8+ T cells and is highly sensitive to immunotherapy. However, tumor-associated macrophages (TAMs), mainly M2 macrophages, tend to undermine the efficacy of immunotherapy and promote the progression of RCC. Here, we fabricated macrophage-derived nanosponges by M2 macrophage membrane-coated PLGA, which could chemotaxis to the CXC and CC chemokine subfamily-enriched RCC microenvironment via corresponding membrane chemokine receptors. Subsequently, the nanosponges acted like cytokine decoys to adsorb and neutralize broad-spectrum immunosuppressive cytokines such as CSF-1, TGF-β, and IL-10, thereby reversing the polarization of M2-TAMs toward the pro-inflammatory M1 phenotype, and enhancing the anti-tumor effect of CD8+ T cells...
April 22, 2024: Advanced Healthcare Materials
#3
JOURNAL ARTICLE
Yao Gao, Yao Wang, Yueyue Luo, Yong Zhang, Saiqi Wang, Xiance Tang, Peng Qin, Benling Xu, Quanli Gao, Tiepeng Li
The aim of this study is to determine whether the pretreatment CD8+PD-1+ to CD4+PD-1+ (PERLS) ratio is an independent risk prognostic factor of advanced melanoma patients. We retrospectively analyzed the efficacy and flow cytometry data from advanced melanoma patients who received PD-1 inhibitor as monotherapy between January 1, 2018 and January 26, 2022. Fifty-nine patients were enrolled, the PERLS cutoff was 1.125. PERLS did not correlate with clinical characteristics but were significantly associated with baseline CD8+, CD4+, and CD8+PD-1+ T cells...
April 22, 2024: Melanoma Research
#4
JOURNAL ARTICLE
Wei Luo, Yiling Li, Liang Wang, Yanhua Qin, Qiao Cheng, Guochang Hu, Chaoyi Yao, Xiangzhi Song
For the first time, three acceptor-donor-acceptor (A-D-A)-type boranil fluorescent dyes, CSU-BF-R (R = H, CH3 , and OCH3 ), featuring phenothiazine as the donor, were designed and synthesized. CSU-BF-R exhibited remarkable photophysical characteristics, including large Stokes shifts (>150 nm), high fluorescence quantum yields (up to 40%), long-wavelength emissions, and strong red solid-state fluorescence. Moreover, these CSU-BF-R fluorescent dyes were demonstrated to function as highly selective and sensitive ratiometric fluorescent probes for detecting hypochlorous acid (HClO)...
April 22, 2024: Organic & Biomolecular Chemistry
#5
Gong-Hong Wei, Dandan Dong, Peng Zhang, Mengqi Liu, Yu Wei, Zixian Wang, Wenjie Xu, Qixiang Zhang, Yao Zhu, Qin Zhang, Xiayun Yang, Jing Zhu, Liang Wang
Genome wide association studies (GWASs) have identified numerous risk loci associated with prostate cancer, yet unraveling their functional significance remains elusive. Leveraging our high-throughput SNPs-seq method, we pinpointed rs4519489 within the multi-ancestry GWAS-discovered 2p25 locus as a potential functional SNP due to its significant allelic differences in protein binding. Here, we conduct a comprehensive analysis of rs4519489 and its associated gene, NOL10, employing diverse cohort data and experimental models...
April 4, 2024: Research Square
#6
JOURNAL ARTICLE
Yao Qin, Zhiyuan Li, Ting Liu, Jingjing Ma, Hong Liu, Yifan Zhou, Shuai Wang, Lei Zhang, Qiao Peng, Pei Ye, Ning Duan, Wenmei Wang, Xiang Wang
PURPOSE: Periodontitis-associated bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are closely linked to the risk of oral squamous cell carcinoma (OSCC). Emerging studies have indicated that another common periodontal pathogen, Prevotella intermedia (P. intermedia), is enriched in OSCC and could affect the occurrence and progression of OSCC. Our aim is to determine the effects of P. intermedia on the progression of OSCC and the role of antibiotics in reversing these effects...
April 21, 2024: Journal of Cancer Research and Clinical Oncology
#7
JOURNAL ARTICLE
Ziqi Yao, Ling Luo, Yongjun Qin, Jiangbo Cheng, Changwei Qu
In order to alleviate environmental problems and reduce CO2 emissions, geopolymers had drew attention as a kind of alkali-activated materials. Geopolymers are easier access to raw materials, green and environment friendly than traditional cement industry. Its special reaction mechanism and gel structure show excellent characteristics such as quick hardening, high strength, acid and alkali resistance. In this paper, geopolymer pastes were made with metakaolin (MK) and ground granulated blast furnace slag (GGBFS) as precursors...
April 20, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Gui-Qiang Fu, Yang-Yang Wang, Yao-Mei Xu, Ming-Ming Bian, Lin Zhang, Hua-Zheng Yan, Jian-Xiong Gao, Jing-Lu Li, Yu-Qing Chen, Nan Zhang, Shu-Qin Ding, Rui Wang, Jiang-Yan Li, Jian-Guo Hu, He-Zuo Lü
Inflammation is one of the key injury factors for spinal cord injury (SCI). Exosomes (Exos) derived from M2 macrophages have been shown to inhibit inflammation and be beneficial in SCI animal models. However, lacking targetability restricts their application prospects. Considering that chemokine receptors increase dramatically after SCI, viral macrophage inflammatory protein II (vMIP-II) is a broad-spectrum chemokine receptor binding peptide, and lysosomal associated membrane protein 2b (Lamp2b) is the key membrane component of Exos, we speculated that vMIP-II-Lamp2b gene-modified M2 macrophage-derived Exos (vMIP-II-Lamp2b-M2-Exo) not only have anti-inflammatory properties, but also can target the injured area by vMIP-II...
April 18, 2024: Experimental Neurology
#9
JOURNAL ARTICLE
Yangyang Zhao, Shengwu Qin, Chaobiao Zhang, Jingyu Yao, Ziyang Xing, Jiasheng Cao, Renchao Zhang
Epistemic uncertainty in data-driven landslide susceptibility assessment often tends to be increased by the limited accuracy of an individual model, as well as uncertainties associated with the selection of non-landslide samples. To address these issues, this paper centers on the landslide disaster in Ji'an City, China, and proposes a heterogeneous ensemble learning method incorporating frequency ratio (FR) and semi-supervised sample expansion. Based on the superimposed results of 12 environmental factor frequency ratios (FFR), non-landslide samples were selected and input into light gradient boosting machine (LightGBM), random forest (RF), and convolutional neural network (CNN) models for prediction along with historical landslide samples...
April 20, 2024: Environmental Science and Pollution Research International
#10
JOURNAL ARTICLE
M Ablikim, M N Achasov, P Adlarson, R Aliberti, A Amoroso, M R An, Q An, Y Bai, O Bakina, I Balossino, Y Ban, V Batozskaya, K Begzsuren, N Berger, M Berlowski, M Bertani, D Bettoni, F Bianchi, E Bianco, J Bloms, A Bortone, I Boyko, R A Briere, A Brueggemann, H Cai, X Cai, A Calcaterra, G F Cao, N Cao, S A Cetin, J F Chang, T T Chang, W L Chang, G R Che, G Chelkov, C Chen, Chao Chen, G Chen, H S Chen, M L Chen, S J Chen, S M Chen, T Chen, X R Chen, X T Chen, Y B Chen, Y Q Chen, Z J Chen, W S Cheng, S K Choi, X Chu, G Cibinetto, S C Coen, F Cossio, J J Cui, H L Dai, J P Dai, A Dbeyssi, R E de Boer, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, B Ding, X X Ding, Y Ding, Y Ding, J Dong, L Y Dong, M Y Dong, X Dong, S X Du, Z H Duan, P Egorov, Y L Fan, J Fang, S S Fang, W X Fang, Y Fang, R Farinelli, L Fava, F Feldbauer, G Felici, C Q Feng, J H Feng, K Fischer, M Fritsch, C Fritzsch, C D Fu, J L Fu, Y W Fu, H Gao, Y N Gao, Yang Gao, S Garbolino, I Garzia, P T Ge, Z W Ge, C Geng, E M Gersabeck, A Gilman, K Goetzen, L Gong, W X Gong, W Gradl, S Gramigna, M Greco, M H Gu, Y T Gu, C Y Guan, Z L Guan, A Q Guo, L B Guo, R P Guo, Y P Guo, A Guskov, X T Hou, T T Han, W Y Han, X Q Hao, F A Harris, K K He, K L He, F H Heinsius, C H Heinz, Y K Heng, C Herold, T Holtmann, P C Hong, G Y Hou, Y R Hou, Z L Hou, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, K X Huang, L Q Huang, X T Huang, Y P Huang, T Hussain, N Hüsken, W Imoehl, M Irshad, J Jackson, S Jaeger, S Janchiv, J H Jeong, Q Ji, Q P Ji, X B Ji, X L Ji, Y Y Ji, Z K Jia, P C Jiang, S S Jiang, T J Jiang, X S Jiang, Y Jiang, J B Jiao, Z Jiao, S Jin, Y Jin, M Q Jing, T Johansson, X Kui, S Kabana, N Kalantar-Nayestanaki, X L Kang, X S Kang, R Kappert, M Kavatsyuk, B C Ke, A Khoukaz, R Kiuchi, R Kliemt, L Koch, O B Kolcu, B Kopf, M K Kuessner, A Kupsc, W Kühn, J J Lane, J S Lange, P Larin, A Lavania, L Lavezzi, T T Lei, Z H Lei, H Leithoff, M Lellmann, T Lenz, C Li, C Li, C H Li, Cheng Li, D M Li, F Li, G Li, H Li, H B Li, H J Li, H N Li, Hui Li, J R Li, J S Li, J W Li, Ke Li, L J Li, L K Li, Lei Li, M H Li, P R Li, S X Li, T Li, W D Li, W G Li, X H Li, X L Li, Xiaoyu Li, Y G Li, Z J Li, Z X Li, Z Y Li, C Liang, H Liang, H Liang, H Liang, Y F Liang, Y T Liang, G R Liao, L Z Liao, J Libby, A Limphirat, D X Lin, T Lin, B J Liu, B X Liu, C Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, G M Liu, H Liu, H B Liu, H M Liu, Huanhuan Liu, Huihui Liu, J B Liu, J L Liu, J Y Liu, K Liu, K Y Liu, Ke Liu, L Liu, L C Liu, Lu Liu, M H Liu, P L Liu, Q Liu, S B Liu, T Liu, W K Liu, W M Liu, X Liu, Y Liu, Y B Liu, Z A Liu, Z Q Liu, X C Lou, F X Lu, H J Lu, J G Lu, X L Lu, Y Lu, Y P Lu, Z H Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, Y F Lyu, F C Ma, H L Ma, J L Ma, L L Ma, M M Ma, Q M Ma, R Q Ma, R T Ma, X Y Ma, Y Ma, Y M Ma, F E Maas, M Maggiora, S Maldaner, S Malde, A Mangoni, Y J Mao, Z P Mao, S Marcello, Z X Meng, J G Messchendorp, G Mezzadri, H Miao, T J Min, R E Mitchell, X H Mo, N Yu Muchnoi, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, Y Niu, S L Olsen, Q Ouyang, S Pacetti, X Pan, Y Pan, A Pathak, P Patteri, Y P Pei, M Pelizaeus, H P Peng, K Peters, J L Ping, R G Ping, S Plura, S Pogodin, V Prasad, F Z Qi, H Qi, H R Qi, M Qi, T Y Qi, S Qian, W B Qian, C F Qiao, J J Qin, L Q Qin, X P Qin, X S Qin, Z H Qin, J F Qiu, S Q Qu, C F Redmer, K J Ren, A Rivetti, V Rodin, M Rolo, G Rong, Ch Rosner, S N Ruan, N Salone, A Sarantsev, Y Schelhaas, K Schoenning, M Scodeggio, K Y Shan, W Shan, X Y Shan, J F Shangguan, L G Shao, M Shao, C P Shen, H F Shen, W H Shen, X Y Shen, B A Shi, H C Shi, J L Shi, J Y Shi, Q Q Shi, R S Shi, X Shi, J J Song, T Z Song, W M Song, Y J Song, Y X Song, S Sosio, S Spataro, F Stieler, Y J Su, G B Sun, G X Sun, H Sun, H K Sun, J F Sun, K Sun, L Sun, S S Sun, T Sun, W Y Sun, Y Sun, Y J Sun, Y Z Sun, Z T Sun, Y X Tan, C J Tang, G Y Tang, J Tang, Y A Tang, L Y Tao, Q T Tao, M Tat, J X Teng, V Thoren, W H Tian, W H Tian, Y Tian, Z F Tian, I Uman, B Wang, B L Wang, Bo Wang, C W Wang, D Y Wang, F Wang, H J Wang, H P Wang, K Wang, L L Wang, M Wang, Meng Wang, S Wang, S Wang, T Wang, T J Wang, W Wang, W Wang, W H Wang, W P Wang, X Wang, X F Wang, X J Wang, X L Wang, Y Wang, Y D Wang, Y F Wang, Y H Wang, Y N Wang, Y Q Wang, Yaqian Wang, Yi Wang, Z Wang, Z L Wang, Z Y Wang, Ziyi Wang, D Wei, D H Wei, F Weidner, S P Wen, C W Wenzel, U W Wiedner, G Wilkinson, M Wolke, L Wollenberg, C Wu, J F Wu, L H Wu, L J Wu, X Wu, X H Wu, Y Wu, Y J Wu, Z Wu, L Xia, X M Xian, T Xiang, D Xiao, G Y Xiao, H Xiao, S Y Xiao, Y L Xiao, Z J Xiao, C Xie, X H Xie, Y Xie, Y G Xie, Y H Xie, Z P Xie, T Y Xing, C F Xu, C J Xu, G F Xu, H Y Xu, Q J Xu, Q N Xu, W Xu, W L Xu, X P Xu, Y C Xu, Z P Xu, Z S Xu, F Yan, L Yan, W B Yan, W C Yan, X Q Yan, H J Yang, H L Yang, H X Yang, Tao Yang, Y Yang, Y F Yang, Y X Yang, Yifan Yang, Z W Yang, M Ye, M H Ye, J H Yin, Z Y You, B X Yu, C X Yu, G Yu, J S Yu, T Yu, X D Yu, C Z Yuan, L Yuan, S C Yuan, X Q Yuan, Y Yuan, Z Y Yuan, C X Yue, A A Zafar, F R Zeng, X Zeng, Y Zeng, Y J Zeng, X Y Zhai, Y H Zhan, A Q Zhang, B L Zhang, B X Zhang, D H Zhang, G Y Zhang, H Zhang, H H Zhang, H H Zhang, H Q Zhang, H Y Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J X Zhang, J Y Zhang, J Z Zhang, Jianyu Zhang, Jiawei Zhang, L M Zhang, L Q Zhang, Lei Zhang, P Zhang, Q Y Zhang, Shuihan Zhang, Shulei Zhang, X D Zhang, X M Zhang, X Y Zhang, X Y Zhang, Y Zhang, Y Zhang, Y T Zhang, Y H Zhang, Yan Zhang, Yao Zhang, Z H Zhang, Z L Zhang, Z Y Zhang, Z Y Zhang, G Zhao, J Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, S J Zhao, Y B Zhao, Y X Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, X Zhong, H Zhou, L P Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, Y Z Zhou, J Zhu, K Zhu, K J Zhu, L Zhu, L X Zhu, S H Zhu, S Q Zhu, T J Zhu, W J Zhu, Y C Zhu, Z A Zhu, J H Zou, J Zu
Using e^{+}e^{-} collision data corresponding to an integrated luminosity of 7.33 fb^{-1} recorded by the BESIII detector at center-of-mass energies between 4.128 and 4.226 GeV, we present an analysis of the decay D_{s}^{+}→π^{+}π^{-}e^{+}ν_{e}, where the D_{s}^{+} is produced via the process e^{+}e^{-}→D_{s}^{*±}D_{s}^{∓}. We observe the f_{0}(980) in the π^{+}π^{-} system and the branching fraction of the decay D_{s}^{+}→f_{0}(980)e^{+}ν_{e} with f_{0}(980)→π^{+}π^{-} measured to be (1...
April 5, 2024: Physical Review Letters
#11
JOURNAL ARTICLE
Haiyin Xu, Xihao Xu, Huifeng He, Hongxia Shao, Yongxiu Yao, Aijian Qin, Kun Qian
Marek's disease virus (MDV) infection causes immunosuppression in the host, ultimately inducing tumor formation and causing significant economic losses to the poultry industry. While the abnormal activation of the Wnt/β-catenin signaling pathway is closely associated with the occurrence and development of tumors. However, the relationship between MDV and the Wnt/β-catenin pathway remains unclear. In this study, we found that the MDV RB1B strain, but not the MDV vaccine strain CVI988, activated the Wnt/β-catenin signaling pathway by increasing the phosphorylation level of GSK-3β in chicken embryo fibroblast (CEF)...
2024: Frontiers in Microbiology
#12
JOURNAL ARTICLE
Chang Tan, Geng Qin, Qian-Qian Wang, Yuan-Chen Zhou, Shu-Kun Yao
OBJECTIVES: Sessile serrated lesions (SSLs) are precursors of sporadic colorectal cancer (CRC) and have distinct characteristics compared with conventional adenomas (CAs). Several lifestyle and environmental factors may play critical roles in the development of advanced lesions. Our aim is to describe the features of SSLs and CAs and further explore risk factors for advanced lesions. METHODS: This is an observational study that collected demographic, endoscopic, and histological data from the China-Japan Friendship Hospital among the inpatient population with pathologically reported as SSL or CA between 2015 and 2022...
2024: Frontiers in Oncology
#13
JOURNAL ARTICLE
Chongqing Zhang, Dongsheng Li, Xin Zhang, Rong Dai, Weiwei Kang, Yao Li, Qin Liu, Mengting Gao, Ziliang Zheng, Ruiping Zhang, Zhaohui Wen
The hypoxic tumor microenvironment (TME) of osteosarcoma (OS) is the Achilles' heel of oxygen-dependent photodynamic therapy (PDT), and tremendous challenges are confronted to reverse the hypoxia. Herein, we proposed a "reducing expenditure of O2 and broadening sources" dual-strategy and constructed ultrasmall IrO2 @BSA-ATO nanogenerators (NGs) for decreasing the O2 -consumption and elevating the O2 -supply simultaneously. As O2 NGs, the intrinsic catalase (CAT) activity could precisely decompose the overexpressed H2 O2 to produce O2 in situ, enabling exogenous O2 infusion...
June 2024: Materials today. Bio
#14
JOURNAL ARTICLE
Yan Qin, Qingqing Liu, Saiying Wang, Qinhui Wang, Yaya Du, Jingyue Yao, Yue Chen, Qi Yang, Yumei Wu, Shuibing Liu, Minggao Zhao, Gaofei Wei, Le Yang
Chronic pain is a complex disease. It seriously affects patients' quality of life and imposes a significant economic burden on society. Santacruzamate A (SCA) is a natural product isolated from marine cyanobacteria in Panama. In this study, we first demonstrated that SCA could alleviate chronic inflammatory pain, pain-related anxiety, and depression emotions induced by complete Freund's adjuvant in mice while inhibiting microglial activation in the anterior cingulate cortex. Moreover, SCA treatment attenuated lipopolysaccharide (LPS)-induced inflammatory response by downregulating interleukin 1β and 6 (IL-1β and IL-6) and tumor necrosis factor-α (TNF-α) levels in BV2 cells...
April 12, 2024: ACS Pharmacology & Translational Science
#15
JOURNAL ARTICLE
Qing Yao, Jing Ding, Xu Yang, Zi-Ying Cai, Su-Qin Han
Notably, clear spatial differences occur in the distribution of air pollution among cities in the Beijing-Tianjin-Hebei (BTH) Region. Clarifying the concentration distribution of PM2.5 and O3 at different time scales is helpful to formulate scientific and effective pollution prevention and control measures. Here, the concentrations of PM2.5 and O3 were decomposed using a seasonal-trend decomposition procedure based on the loess (STL) method; their long-term, seasonal, and short-term components were obtained; and their temporal and spatial distribution characteristics were studied...
May 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
#16
JOURNAL ARTICLE
Qin Huang, Lei Liu, Shuo Zhang, Yao Yu, Yantong Yang, Xianjin Zhu, Zunjing Liu
BACKGROUND: Relatively little is known about the plaque characteristics of border-zone infarcts and how they differ between cortical border-zone (CBZ) and internal border-zone (IBZ) infarcts. METHODS: We conducted a retrospective observational cohort study of patients with intracranial atherosclerotic disease who underwent high-resolution magnetic resonance imaging (HR-MRI) examination. Individuals with border-zone infarcts in the middle cerebral artery (MCA) territory, detected by diffusion-weighted imaging, were enrolled...
April 15, 2024: Academic Radiology
#17
JOURNAL ARTICLE
Haonan Pei, Sisi Jiang, Mei Liu, Guofeng Ye, Yun Qin, Yayun Liu, Mingjun Duan, Dezhong Yao, Cheng Luo
Schizophrenia is accompanied by aberrant interactions of intrinsic brain networks. However, the modulatory effect of electroencephalography (EEG) rhythms on the functional connectivity (FC) in schizophrenia remains unclear. This study aims to provide new insight into network communication in schizophrenia by integrating FC and EEG rhythm information. After collecting simultaneous resting-state EEG-functional magnetic resonance imaging data, the effect of rhythm modulations on FC was explored using what we term "dynamic rhythm information...
April 13, 2024: International Journal of Neural Systems
#18
JOURNAL ARTICLE
Shi-Qin Cai, Su-Fang Zhou, Li-Fang Zhou, Yu-Ru Li, Xiang-Yu Zhou, Fang-Yi Lyu
This study aims to investigate the regulatory effects of Shenling Baizhu Powder(SBP) on cellular autophagy in alcoholic liver disease(ALD) and its intervention effect through the TLR4/NLRP3 pathway. A rat model of chronic ALD was established by gavage of spirits. An ALD cell model was established by stimulating BRL3A cells with alcohol. High-performance liquid chromatography(HPLC) was utilized for the compositional analysis of SBP. Liver tissue from ALD rats underwent hematoxylin-eosin(HE) and oil red O staining for pathological evaluation...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#19
JOURNAL ARTICLE
Ji-Xin Chen, Qin-Xin Zhou, Wei-Jie Yu, Tian-Ci Guo, Pu-Yu Niu, Yun-Tian Ye, Ai-Feng Liu
This study assesses the status of outcome measures in the randomized controlled trial(RCT) involving the kidney-tonif-ying and blood-activating method for treating knee osteoarthritis(KOA), aiming to establish a theoretical foundation for the development of a core set of outcome measures in traditional Chinese medicine(TCM) treatment of KOA. The relevant articles were retrieved from CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science, in addition to ClinicalTrials.gov and the China Clinical Trial Registration Center, with the time interval from inception to August 2023...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#20
JOURNAL ARTICLE
Zhi Qin, Min Zhou
This study investigated the protective effect of tanshinone Ⅱ_A(TSⅡ_A) on the liver in the rat model of non-alcoholic fatty liver disease(NAFLD) and the mechanism of TSⅡ_A in regulating ferroptosis via the nuclear factor E2-related factor 2(Nrf2) signaling pathway. The rat model of NAFLD was established with a high-fat diet for 12 weeks. The successfully modeled rats were assigned into model group, low-and high-dose TSⅡ_A groups, and inhibitor group, and normal control group was set...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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