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Qin Yao

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https://www.readbyqxmd.com/read/29453967/discovery-of-anti-viral-molecules-and-their-vital-functions-in-bombyx-mori
#1
REVIEW
Peng Lü, Ye Pan, Yanhua Yang, Feifei Zhu, Chengjun Li, Qin Yao, Keping Chen
The silkworm Bombyx mori (B. mori), a lepidopteran model organism, has become an important model for molecular biology researches with its genome completely sequenced. Silkworms confront different types of virus diseases, mainly including those caused by Bombyx mori nucleopolyhedrovirus (BmNPV), Bombyx mori densovirus type 1 (BmDNV-1), Bombyx mori bidesovirus (BmBDV) which was termed as Bombyx mori densovirus type 2 (BmDNV-2) or Bombyx mori parvo-like virus (BmPLV) before in sericulture. B. mori offers excellent models to study the molecular mechanisms of insect innate immune responses to viruses...
February 14, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29445153/development-of-a-chimeric-zika-vaccine-using-a-licensed-live-attenuated-flavivirus-vaccine-as-backbone
#2
Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D Davidson, Ya-Jun Song, Pei-Yong Shi, Cheng-Feng Qin
The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, while exhibiting an attenuation phenotype in multiple animal models...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29445150/loss-of-ndrg2-in-liver-microenvironment-inhibits-cancer-liver-metastasis-by-regulating-tumor-associate-macrophages-polarization
#3
Mengyang Li, Xiaofeng Lai, Ying Zhao, Yuan Zhang, Minghui Li, Danxiu Li, Jing Kong, Yong Zhang, Pengyu Jing, Huichen Li, Hongyan Qin, Liangliang Shen, Libo Yao, Jipeng Li, Kefeng Dou, Jian Zhang
The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion of inhibitory factors, may be a potential therapeutic strategy for liver cancer metastasis treatment.We first cloned NDRG2 (N-myc downstream-regulated gene 2) and verified its tumor suppressor role in multiple solid tumors, including colorectal cancer and hepatocellular carcinoma...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29442739/one-pot-strategy-to-bi%C3%A2-s%C3%A2-biocl-heterojunction-with-enhanced-photocatalytic-activity
#4
Ji-Yao Tao, Qiao-Feng Han, Xiao-Qin Huang, Wei-Teng Ma
Bi2S3/BiOCl (denoted as BS-BC) heterojunction photocatalyst has been reported to be able to increase light absorption, promote charge separation and consequently enhance photocatalytic efficiency in comparison with single BiOCl. However, the heterojunction was usually prepared by a two-step method, i.e., BiOCl was firstly prepared and then to BS-BC heterojunction through an ion exchange strategy. In this work, BS-BC was prepared by a one-pot room temperature route, where Bi(NO3)3 dissolved in aqueous urea solution could homogeneously react with a mixture solution of NaCl and thiacetamide (TAA) to form BS-BC heterojunction...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441271/synthesis-and-characterization-of-electrospun-molybdenum-dioxide-carbon-nanofibers-as-sulfur-matrix-additives-for-rechargeable-lithium-sulfur-battery-applications
#5
Ruiyuan Zhuang, Shanshan Yao, Maoxiang Jing, Xiangqian Shen, Jun Xiang, Tianbao Li, Kesong Xiao, Shibiao Qin
One-dimensional molybdenum dioxide-carbon nanofibers (MoO2-CNFs) were prepared using an electrospinning technique followed by calcination, using sol-gel precursors and polyacrylonitrile (PAN) as a processing aid. The resulting samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, Brunauer-Emmet-Teller (BET) surface area measurements, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). MoO2-CNFs with an average diameter of 425-575 nm obtained after heat treatment were used as a matrix to prepare sulfur/MoO2-CNF cathodes for lithium-sulfur (Li-S) batteries...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29439045/draft-whole-genome-sequences-of-zhihengliuella-halotolerans-la12-and-microbacterium-kitamiense-sa12-strains-with-cellulase-activity-isolated-from-the-qinghai-tibetan-plateau
#6
Mingming Chen, Na Qin, Wenqin Pei, Qianhui Li, Qing Yang, Yao Chen, Duntao Huang, Yingying Xiang, Ling Lin
We report the complete genome sequences of cellulolytic strains Zhihengliuella halotolerans La12 and Microbacterium kitamiense Sa12, which were isolated from soil samples collected from the Qinghai-Tibetan Plateau in Western China. The final assemblies of La12 and Sa12 comprise 3,712,694 bp, with over 111 contigs, and 3,830,439 bp, with over 39 contigs, respectively.
February 8, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29435142/co-expression-analysis-revealed-ptch1-3-utr-promoted-cell-migration-and-invasion-by-activating-mir-101-3p-slc39a6-axis-in-non-small-cell-lung-cancer-implicating-the-novel-function-of-ptch1
#7
Xuechao Wan, Zhe Kong, Kaili Chu, Chuanyou Yi, Jian Hu, Rui Qin, Chen Zhao, Fangqiu Fu, Hai Wu, Yao Li, Yan Huang
Metastasis is the most common cause of mortality for non-small cell lung cancer (NSCLC). PTCH1, a receptor of Hedgehog (Hh) pathway, is reported to suppress cell proliferation. Interestingly, our previous study showed PTCH1 silencing promoted cell proliferation but inhibited cell migration and invasion of NSCLC cells. However, the precise mechanisms of PTCH1 regulating NSCLC metastasis remain unclear. PTCH1 has multiple splicing variants, which all share the same 3'UTR sequence, meanwhile, emerging studies have shown competing endogenous RNAs (ceRNAs) play important roles in regulating cancer progression...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434799/inhibition-of-x-linked-inhibitor-of-apoptosis-protein-enhances-anti-tumor-potency-of-pure-total-flavonoids-on-the-growth-of-leukemic-cells
#8
Liqiang Wu, Xiuxia Zhang, Xiaojie Lin, Bo Wang, Chang Huang, Yao Qin, Shengyun Lin
Flavonoids, a vast group of polyphenols widely distributed in plants, are known to possess a range of biological activities and potential anti-tumor effects. X-linked inhibitor of apoptosis protein (XIAP) promotes the progression of leukemia by preventing tumor cells undergoing apoptosis. The present study investigated the potential effects and underlying mechanisms of pure total flavonoids from Citrus paradisi Macfad (PTFC) on human U937 cells, and explored the effects of short hairpin (sh)RNA-mediated XIAP knockdown on the anti-cancer effects of PTFC...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428945/a-meta-analysis-of-the-diagnostic-accuracy-of-circular-rnas-in-digestive-system-malignancy
#9
Zhiqiang Chen, Long Zhang, Guoyong Han, Xueliang Zuo, Yao Zhang, Qin Zhu, Jindao Wu, Xuehao Wang
BACKGROUND/AIMS: Circular RNAs (circRNAs), a novel class of noncoding RNAs, have been found to be dysregulated in various cancers. However, the clinical application value of these circRNAs in digestive system cancers remains to be clarified. We aimed to comprehensively explore the potential role of circRNAs as diagnostic indicators in digestive system malignancies. METHODS: Relevant studies were systematically retrieved from PubMed, Web of Science and the Cochrane Library...
February 2, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29427790/activation-of-nrf2-by-ginsenoside-rh3-protects-retinal-pigment-epithelium-cells-and-retinal-ganglion-cells-from-uv
#10
Chun-Zhou Tang, Ke-Ran Li, Qing Yu, Qin Jiang, Jin Yao, Cong Cao
Excessive Ultra-violet (UV) radiation shall induce damages to resident retinal pigment epithelium (RPE) cells (RPEs) and retinal ganglion cells (RGCs). Here we tested the potential activity of Ginsenoside Rh3 ("Rh3") against the process. In cultured human RPEs and RGCs, pretreatment with Rh3 inhibited UV-induced reactive oxygen species (ROS) production and following apoptotic/non-apoptotic cell death. Rh3 treatment in retinal cells induced nuclear-factor-E2-related factor 2 (Nrf2) activation, which was evidenced by Nrf2 protein stabilization and its nuclear translocation, along with transcription of antioxidant responsive element (ARE)-dependent genes (HO1, NOQ1 and GCLC)...
February 7, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29426357/14-15-eet-induces-breast-cancer-cell-emt-and-cisplatin-resistance-by-up-regulating-integrin-%C3%AE-v%C3%AE-3-and-activating-fak-pi3k-akt-signaling
#11
Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu
BACKGROUND: 14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, the role and molecular mechanisms of 14,15-EET activity in breast cancer cell epithelial-mesenchymal transition (EMT) and drug resistance remain enigmatic. METHODS: The 14, 15-EET level in serum and in tumor or non-cancerous tissue from breast cancer patients was measured by ELISA. qRT-PCR and western blot analyses were used to examine expression of integrin αvβ3...
February 9, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29425744/lncrna-uc-173-is-a-key-molecule-for-the-regulation-of-lead-induced-renal-tubular-epithelial-cell-apoptosis
#12
Jiabi Qin, Huacheng Ning, Yao Zhou, Yue Hu, Bo Huang, Yue Wu, Ruixue Huang
Transcribed ultra-conserved region (T-UCR) transcripts are a novel class of long non-coding RNAs (lncRNAs) transcribed from ultra-conserved region which is highly conserved in human, rat, and mouse genome. LncRNA UC.173 has been found significantly down-regulated in lead-exposed population and lead-exposed animal mode, and had an inhibitory effect on lead-induced nerve cell apoptosis. We supposed that lncRNA UC.173 had an inhibitory effect on lead-induced renal tubular epithelial cell apoptosis. Thus, the aim of our study was to explore the function of lncRNA UC...
February 6, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29424796/activation-of-sigma-1-receptor-by-cutamesine-attenuates-neuronal-apoptosis-by-inhibiting-endoplasmic-reticulum-stress-and-mitochondrial-dysfunction-in-a-rat-model-of-asphyxia-cardiac-arrest
#13
Jiahong Qin, Peng Wang, Yi Li, Lan Yao, Yuanshan Liu, Tao Yu, Jiali Lin, Xiangshao Fang, Zitong Huang
BACKGROUND: Global cerebral ischemic/reperfusion (I/R) injury after cardiac arrest (CA) is a major cause of mortality and morbidity in survivors of resuscitation. We utilized a rat model of asphyxia CA to explore the functional effects and mechanisms of Sigma-1 receptor (Sig-1R) activation in cerebral protection using the Sig-1R agonist cutamesine (SA-4503). METHODS: After resuscitation, the surviving rats were randomly divided into three groups (n = 18 each): (1) the CPR group (0...
February 8, 2018: Shock
https://www.readbyqxmd.com/read/29423083/betulinic-acid-impairs-metastasis-and-reduces-immunosuppressive-cells-in-breast-cancer-models
#14
An-Qi Zeng, Yan Yu, Yu-Qin Yao, Fang-Fang Yang, Mengya Liao, Lin-Jiang Song, Ya-Li Li, Yang Yu, Yu-Jue Li, Yuan-Le Deng, Shu-Ping Yang, Chen-Juan Zeng, Ping Liu, Yong-Mei Xie, Jin-Liang Yang, Yi-Wen Zhang, Ting-Hong Ye, Yu-Quan Wei
Breast cancer is the most common female cancer with considerable metastatic potential, explaining the need for new candidates that inhibit tumor metastasis. In our study, betulinic acid (BA), a kind of pentacyclic triterpenoid compound derived from birch trees, was evaluated for its anti-metastasis activity in vitro and in vivo. BA decreased the viability of three breast cancer cell lines and markedly impaired cell migration and invasion. In addition, BA could inhibit the activation of stat3 and FAK which resulted in a reduction of matrix metalloproteinases (MMPs), and increase of the MMPs inhibitor (TIMP-2) expression...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414450/peak-circulatory-power-is-a-strong-prognostic-factor-in-patients-with-idiopathic-pulmonary-arterial-hypertension
#15
Yi Tang, Lei Yao, Zhihong Liu, Wenlin Xie, Xiuping Ma, Qin Luo, Zhihui Zhao, Zhiwei Huang, Liu Gao, Qi Jin, Xue Yu, Changming Xiong, Xinhai Ni, Yinkun Yan, Wenwei Qi
BACKGROUND: Studies have shown that peak circulatory power (peak CircP; peak oxygen uptake × peak systolic blood pressure) is a variable predictor of prognosis in patients with left heart failure. It remains unknown whether peak CircP also predicts outcome in patients with idiopathic pulmonary arterial hypertension (IPAH). METHODS: Patients with newly diagnosed IPAH who underwent symptom-limited cardiopulmonary exercise testing (CPET) from 1 January 2011 to 1 January 2014 in Fuwai Hospital were prospectively enrolled and followed for up to 66 months for cardiac events (mortality and lung transplantation)...
February 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29411136/mutation-of-i176r-in-the-e-coding-region-weakens-japanese-encephalitis-virus-neurovirulence-but-not-its-growth-rate-in-bhk-21-cells
#16
Yuyong Zhou, Rui Wu, Qin Zhao, Yung-Fu Chang, Xintian Wen, Yao Feng, Xiaobo Huang, Yiping Wen, Qigui Yan, Yong Huang, Xiaoping Ma, Xinfeng Han, Sanjie Cao
Previously, we isolated the Japanese encephalitis virus (JEV) strain SCYA201201. In this study, we passed the SCYA201201 strain in Syrian baby hamster kidney (BHK-21) cells 120 times to obtain the SCYA201201-0901 strain, which exhibited an attenuated phenotype in mice. Comparison of SCYA201201-0901 amino acid sequences with those of other JEV strains revealed a single mutation, I176R, in the E coding region. Using reverse genetic technology, we provide evidence that this single E-I176R mutation does not affect virus growth in BHK-21 cells but significantly decreases JEV neurovirulence in mice...
February 6, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29409883/long-non-coding-rna-meg3-silencing-protects-against-light-induced-retinal-degeneration
#17
Yun-Xi Zhu, Jin Yao, Chang Liu, Hai-Tao Hu, Xiu-Miao Li, Hui-Min Ge, Yun-Fan Zhou, Kun Shan, Qin Jiang, Biao Yan
Excessive light exposure leads to retinal degeneration and accelerates the progression and severity of several ocular diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa. Long non-coding RNAs (LncRNAs) have emerged as important regulators of photoreceptor development and ocular diseases. In this study, we investigated the role of lncRNA-MEG3 in light-induced retinal degeneration. MEG3 expression was significantly up-regulated after light insult in vivo and in vitro. MEG3 silencing protected against light-induced retinal degeneration in vivo and light-induced photoreceptor cell apoptosis in vitro...
January 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29409115/expression-of-nerve-growth-factor-carried-by-pseudotyped-lentivirus-improves-neuron-survival-and-cognitive-functional-recovery-of-post-ischemia-in-rats
#18
Jia-Yu Cao, Yong Lin, Yan-Fei Han, Sheng-Hao Ding, Yi-Ling Fan, Yao-Hua Pan, Bing Zhao, Qin-Hua Guo, Wen-Hua Sun, Jie-Qing Wan, Xiao-Ping Tong
AIMS: Nerve growth factor (NGF) has been reported to prevent neuronal damage and contributes to the functional recovery in animal brain injury models and human ischemic disease as well. We aimed to investigate a potential therapeutic effect of NGF gene treatment in ischemic stroke and to estimate the functional recovery both at the cellular and cognitive levels in an ischemia rat model. METHODS: After microinjection of pseudolentivirus-delivered β-NGF into an established ischemic stroke model in rats (tMCAO), we estimated neuronal cell apoptosis with TUNEL labeling and neurogenesis by cell proliferation marker Ki67 staining in both ischemic core and penumbra of striatum...
February 6, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29408211/characterization-of-the-inserted-mutagenesis-dextransucrases-from-leuconostoc-mesenteroides-0326-to-produce-hyperbranched-dextran
#19
Chao Wang, Shuang Chen, Hong-Bin Zhang, Yao Li, Xue-Qin Hu
Dextran produced by dextransucrase hold strong potential for industrial applications. The exact determinants of the linkage specificity of glucansucrase enzymes have remained largely unknown. Previous studies have investigated the relationships between structure and linkage specificity of the dextransucrase DSR from Leuconostoc mesenteroides by the site-directed mutagenesis of the catalytic pocket. The glycosidic linkage of dextran produced by mutant enzymes changed slightly by 3% to 20%. The mutagenesis dextransucrases were constructed by inserting an amino acid into a catalytic pocket to investigate the product specificities of dextransucrase thoroughly...
February 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29408142/-on-off-on-fluorescent-system-for-detection-of-zn2-in-biological-samples-using-quantum-dots-carbon-dots-ratiometric-nanosensor
#20
Quan Song, Yunsu Ma, Xu Wang, Tang Tang, Yueyue Song, Yujie Ma, Guanhong Xu, Fangdi Wei, Yao Cen, Qin Hu
In this work, a novel strategy for Zn2+ detection was established by using an "on-off-on" ratiometric fluorescent nanosensor with the help of ethylene diaminetetraacetic acid (EDTA), a common metal chelating agent. The simple and practical ratiometric fluorescent nanosensor was synthesized by covalently binding CdTe quantum dots (QDs) and carbon dots (CDs), possessing two emission peaks at 525 nm and 450 nm under a single wavelength excitation of 360 nm, respectively. The CdTe QDs served as the response signal label, and the CDs, having no response to the analytes, acted as the reference signal...
February 1, 2018: Journal of Colloid and Interface Science
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