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Qin Yao

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https://www.readbyqxmd.com/read/29670377/crocin-induces-autophagic-apoptosis-in-hepatocellular-carcinoma-by-inhibiting-akt-mtor-activity
#1
Chong Yao, Bing-Bing Liu, Xiao-Dong Qian, Li-Qin Li, Heng-Bin Cao, Qiao-Sheng Guo, Gui-Fen Zhou
Background: Autophagy induction is a common mechanism for antitumor chemicals in induction of cancer cell death. However, the role of autophagy in crocin-induced apoptosis is barely studied in hepatocellular carcinoma (HCC). Materials and methods: The influence of crocin on growth, apoptosis, and autophagy and its mutual relations were analyzed by Cell Counting Kit-8 assay, flow cytometer, EGFP-LC3 puncta analysis, and Western blot in HCC cells. The activities of Akt/mTOR axis and its roles in autophagy regulation were also detected by Western blot in HCC cells treated with crocin...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29665788/medical-expenses-of-urban-chinese-patients-with-stomach-cancer-during-2002-2011-a-hospital-based-multicenter-retrospective-study
#2
Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song, Yu-Qin Liu, Lin Zhu, Ling-Bin Du, Qi Zhou, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Yuanzheng Wang, Rong Cao, Ying Ren, Li Lan, Kai Zhang, Jie He, Jia-Lin Wang, Min Dai
BACKGROUND: In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients' medical expenses and their associated trends. The Cancer Screening Program in Urban China (CanSPUC) is a Major Public Health Project funded by the central government. Through this project, we have extracted patients' medical expenses from hospital billing data to examine the costs of the first course treatments (which refers to 2 months before and 10 months after the date of cancer diagnosis) in Chinese patients with stomach cancer and the associated trends...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29662877/soluble-molecularly-imprinted-nanorods-for-homogeneous-molecular-recognition
#3
Rongning Liang, Tiantian Wang, Huan Zhang, Ruiqing Yao, Wei Qin
Nowadays, it is still difficult for molecularly imprinted polymers (MIPs) to achieve homogeneous recognition since they cannot be easily dissolved in organic or aqueous phase. To address this issue, soluble molecularly imprinted nanorods have been synthesized by using soluble polyaniline doped with a functionalized organic protonic acid as the polymer matrix. By employing 1-naphthoic acid as a model, the proposed imprinted nanorods exhibit an excellent solubility and good homogeneous recognition ability. The imprinting factor for the soluble imprinted nanoroads is 6...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29656060/microrna-96-acts-as-a-tumor-suppressor-gene-in-human-osteosarcoma-via-target-regulation-of-ezrin
#4
Qin Yao, Yihua Pei, Xin Zhang, Bozhen Xie
AIMS: microRNA-96 (miR-96) is considered as a tumor suppressor in multiple malignancies. Some studies have indicated that EZRIN could be regulated by the miR-96 in several kinds of cancer cells. However, the function of miR-96 in human osteosarcoma has not been investigated intensively so far. In this study, we mainly explored the relationship between miR-96 and the expression of EZRIN in human osteosarcoma cells. MAIN METHODS: The levels of miR-96 and EZRIN in osteosarcoma tissues and paracancerous tissues of patients were evaluated with qPCR...
April 12, 2018: Life Sciences
https://www.readbyqxmd.com/read/29650044/human-amnion-derived-mesenchymal-stem-cells-alleviate-lung-injury-induced-by-white-smoke-inhalation-in-rats
#5
Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong, Zhaofan Xia
BACKGROUND: White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This study aimed to determine the protective effects of human amnion-derived mesenchymal stem cells (hAMSCs) against WSI-induced lung injury in rats. METHODS: hAMSCs were injected into rats via the tail vein 4 h after WSI. At 1, 3, 7, 14, and 28 days after cell injection, hAMSCs labeled with PKH26 in lung, heart, liver, and kidney tissues were observed by fluorescence microscopy...
April 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29642935/sp1-induced-upregulation-of-lncrna-spry4-it1-exerts-oncogenic-properties-by-scaffolding-ezh2-lsd1-dnmt1-and-sponging-mir-101-3p-in-cholangiocarcinoma
#6
Yi Xu, Yue Yao, Xingming Jiang, Xiangyu Zhong, Zhidong Wang, Chunlong Li, Pengcheng Kang, Kaiming Leng, Daolin Ji, Zhenglong Li, Lining Huang, Wei Qin, Yunfu Cui
BACKGROUND: Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) behave as a novel class of transcription products during multiple cancer processes. However, the mechanisms responsible for their alteration in cholangiocarcinoma (CCA) are not fully understood. METHODS: The expression of SPRY4-IT1 in CCA tissues and cell lines was determined by RT-qPCR, and the association between SPRY4-IT1 transcription and clinicopathologic features was analyzed...
April 11, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29620641/expression-and-prognostic-value-of-lactate-dehydrogenase-a-and-d-subunits-in-human-uterine-myoma-and-uterine-sarcoma
#7
Ke-Juan Song, Xiao-Ni Yu, Teng Lv, Yu-Long Chen, Yu-Chao Diao, Su-Li Liu, Yan-Kui Wang, Qin Yao
OBJECTIVE: This study aimed to determine the expression of lactate dehydrogenase (LDH)-A and LDH-D in patients with uterine myoma, cellular leiomyoma (CLM), and uterine sarcoma and to evaluate their prognostic significance. METHODS: Protein expression levels of LDH-A and LDH-D were determined in tissue samples from 86 patients (26 uterine myoma, 10 CLM, 50 uterine sarcoma) by immunohistochemistry and their associations with clinicopathologic parameters and outcomes were analyzed in patients with uterine sarcoma...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29618723/enhanced-protection-in-mice-induced-by-immunization-with-inactivated-whole-viruses-compare-to-spike-protein-of-middle-east-respiratory-syndrome-coronavirus
#8
Yao Deng, Jiaming Lan, Linlin Bao, Baoying Huang, Fei Ye, Yingzhu Chen, Yanfeng Yao, Wenling Wang, Chuan Qin, Wenjie Tan
The persistent public health threat of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective and safe MERS-CoV vaccine. In this study, we prepared and vaccinated mice with either a Spike (S) protein or inactivated whole MERS-CoV (IV) with a combined adjuvant (alum+CpG) as a vaccine formulation. Similar levels of the anti-S protein IgG response and neutralizing activity were induced by both the S protein and IV vaccines. In addition, immune responses against three other structural proteins, the envelope (E), membrane (M), and nucleocapsid (N) proteins, were also detected in sera of mice that received IV...
April 4, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29618640/porcine-deltacoronavirus-engages-the-transmissible-gastroenteritis-virus-functional-receptor-porcine-aminopeptidase-n-for-infectious-cellular-entry
#9
Bin Wang, Yan Liu, Chun-Miao Ji, Yong-Le Yang, Qi-Zhang Liang, Pengwei Zhao, Ling-Dong Xu, Xi-Mei Lei, Wen-Ting Luo, Pan Qin, Jiyong Zhou, Yao-Wei Huang
Identification of cellular receptors used by coronavirus (CoV) entry into the host cells is critical to understand pathogenesis and to develop intervention strategies. The fourth CoV genus, Deltacoronavirus , evolutionally related to the Gammacoronavirus , has just been defined recently. In the current study, we demonstrate that porcine aminopeptidase N (pAPN) acts as a cross-genus CoV functional receptor for both enteropathogenic porcine DeltaCoV (PDCoV) and AlphaCoV (transmissible gastroenteritis virus, TGEV) based upon three lines of evidences...
April 4, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29616503/a-novel-endogenous-badnavirus-exists-in-alhagi-sparsifolia
#10
Yong-Chao Li, Jian-Guo Shen, Guo-Huan Zhao, Qin Yao, Wei-Min Li
We report the recovery of a 7068-nt viral sequence from the "viral fossils" embedded in the genome of Alhagi sparsifolia, a typical desert plant. Although the full viral genome remains to be completed, the putative genome structure, the deduced amino acids and phylogenetic analysis unambiguously demonstrate that this viral sequence represents a novel species of the genus Badnavirus. The putative virus is tentatively termed Alhagi bacilliform virus (ABV). Southern blotting and inverse polymerase chain reaction (PCR) data indicate that the ABV-related sequence is integrated into the A...
2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29608986/survivin-targeted-drug-screening-platform-identifies-a-matrine-derivative-wm-127-as-a-potential-therapeutics-against-hepatocellular-carcinoma
#11
Haisen Yin, Risheng Que, Chunying Liu, Weidan Ji, Bin Sun, Xuejing Lin, Qin Zhang, Xinying Zhao, Zhangxiao Peng, Xiaofeng Zhang, Haihua Qian, Lei Chen, Yonggang Yao, Changqing Su
Hepatocellular carcinoma (HCC) is the second leading cause of cancer related death which needs novel drugs to improve patient outcome. Survivin overexpresses in HCC and contributes to HCC malignant progression. In this study, we established a Survivin-targeted drug screening platform, a cell model HepG2-Sur5P-EGFP-Sur3U stably transfected with lentivirus carrying an EGFP expression cassette, in which the EGFP expression was regulated by the upstream Survivin promoter and downstream Survivin 3'-UTR. By using this platform, we screened and easily identified one of matrine derivatives, WM-127, from hundreds of matrine derivatives...
March 30, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29605839/genomic-changes-in-an-attenuated-genotype-i-japanese-encephalitis-virus-and-comparison-with-virulent-parental-strain
#12
Yuyong Zhou, Rui Wu, Yao Feng, Qin Zhao, Xintian Wen, Xiaobo Huang, Yiping Wen, Qigui Yan, Yong Huang, Xiaoping Ma, Xinfeng Han, Sanjie Cao
Genotype I Japanese encephalitis virus (JEV) strain SCYA201201 was previously isolated from brain tissues of aborted piglets. In this study, we obtained an attenuated SCYA201201-0901 strain by serial passage of strain SCYA201201-1 in Syrian baby hamster kidney cells, combined with multiple plaque purifications and selection for virulence in mice. We investigated the genetic changes associated with attenuation by comparing the entire genomes of SCYA201201-0901 and SCYA201201-1. Sequence comparisons identified 14 common amino acid substitutions in the coding region, with two nucleotide point mutations in the 5'-untranslated region (UTR) and another three in the 3'-UTR, which differed between the attenuated and virulent strains...
March 31, 2018: Virus Genes
https://www.readbyqxmd.com/read/29605301/hsa_circ_0007534-mir-761-zic5-regulatory-loop-modulates-the-proliferation-and-migration-of-glioma-cells
#13
Guang-Feng Li, Li Li, Zong-Qin Yao, Su-Jing Zhuang
Increasing evidences demonstrate the essential roles of circular RNAs (circRNAs) in human cancers. However, the study about the functions of circRNAs in glioma remains very limited. In the present study, we found that circRNA hsa_circ_0007534 was highly expressed in glioma tissues compared to normal brain tissues. Furthermore, we found that knockdown of hsa_circ_0007534 significantly inhibited the proliferation and migration of glioma cells. In mechanism, we showed that hsa_circ_0007534 could sponge miR-761 to repress its availability in glioma cells...
March 29, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29600168/a-recurrent-g367r-mutation-in-myoc-associated-with-juvenile-open-angle-glaucoma-in-a-large-chinese-family
#14
Yi-Hua Yao, Ya-Qin Wang, Wei-Fang Fang, Liu Zhang, Ju-Hua Yang, Yi-Hua Zhu
AIM: To identify the mutations of MYOC , OPTN , CYP1B1 and WDR36 in a large Chinese family affected by juvenile open angle glaucoma (JOAG). METHODS: Of 114 members of one family were recruited in this study. Blood samples from twelve members of this pedigree were collected for further research. As a control, 100 unrelated subjects were recruited from the same hospital. The exon and flanking intron sequences of candidate genes were amplified using the polymerase chain reaction and direct DNA sequencing...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29597131/health-related-quality-of-life-and-utility-scores-of-patients-with-breast-neoplasms-in-china-a-multicenter-cross-sectional-survey
#15
Le Wang, Ju-Fang Shi, Juan Zhu, Hui-Yao Huang, Ya-Na Bai, Guo-Xiang Liu, Xian-Zhen Liao, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Lan-Wei Guo, Yi Fang, Qi Zhou, Heng-Min Ma, Xiao-Jing Xing, Lin Zhu, Bing-Bing Song, Ling-Bin Du, Ling Mai, Yu-Qin Liu, Ying Ren, Li Lan, Jin-Yi Zhou, Xiao Qi, Xiao-Hua Sun, Pei-An Lou, Shou-Ling Wu, Ni Li, Kai Zhang, Jie He, Min Dai
BACKGROUND: Health-related quality of life and utility scores of patients with breast cancer and precancerous lesions are sparse in China. This study aimed to derive utility scores of patients with breast cancer and precancer in China. MATERIAL AND METHODS: An interviewer-administered cross-sectional survey was conducted in 12 provinces across China from 2013 to 2014. The three-level EuroQol-5-Dimension instrument was used to evaluate quality of life, and utility scores were generated using the Chinese value set...
March 26, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29596529/genome-wide-identification-of-wheat-triticum-aestivum-expansins-and-expansin-expression-analysis-in-cold-tolerant-and-cold-sensitive-wheat-cultivars
#16
Jun-Feng Zhang, Yong-Qing Xu, Jia-Min Dong, Li-Na Peng, Xu Feng, Xu Wang, Fei Li, Yu Miao, Shu-Kuan Yao, Qiao-Qin Zhao, Shan-Shan Feng, Bao-Zhong Hu, Feng-Lan Li
Plant expansins are proteins involved in cell wall loosening, plant growth, and development, as well as in response to plant diseases and other stresses. In this study, we identified 128 expansin coding sequences from the wheat (Triticum aestivum) genome. These sequences belong to 45 homoeologous copies of TaEXPs, including 26 TaEXPAs, 15 TaEXPBs and four TaEXLAs. No TaEXLB was identified. Gene expression and sub-expression profiles revealed that most of the TaEXPs were expressed either only in root tissues or in multiple organs...
2018: PloS One
https://www.readbyqxmd.com/read/29594678/aptamer-based-fluorometric-%C3%AE-lactoglobulin-assay-based-on-the-use-of-magnetic-nanoparticles-and-carbon-dots
#17
Menglan Shi, Yao Cen, Muhammad Sohail, Guanhong Xu, Fangdi Wei, Yunsu Ma, Xiaoman Xu, Yujie Ma, Yueyue Song, Qin Hu
The authors describe a fluorometric aptamer based assay for detecting β-lactoglobulin by using carbon dots (C-dots) as a signal indicator. The aptamer was immoblized on magnetite (Fe3 O4 ) nanoparticles (MNPs), and the C-dots served as a label for the complementary oligonucleotide (cDNA). The assay is based on the hybridization that takes place between aptamer and cDNA. In the presence of β-lactoglobulin (β-LG), the aptamer preferentially binds to β-LG, and this leads to a partial release of the C-dots-cDNA into the solution...
December 8, 2017: Mikrochimica Acta
https://www.readbyqxmd.com/read/29594574/aptamer-based-fluorescent-platform-for-ultrasensitive-adenosine-detection-utilizing-fe-3-o-4-magnetic-nanoparticles-and-silver-nanoparticles
#18
Yueyue Song, Guanhong Xu, Fangdi Wei, Yao Cen, Muhammad Sohail, Menglan Shi, Xiaoman Xu, Yunsu Ma, Yujie Ma, Qin Hu
The authors describe an aptamer-based fluorescent assay for adenosine (Ade). It is based on the interaction between silver nanoparticles (AgNPs) and CdTe quantum dots (QDs). The beacon comprises a pair of aptamers, one conjugated to Fe3 O4 magnetic nanoparticles, the other to AgNPs. In the presence of Ade, structural folding and sandwich association of the two attachments takes place. After magnetic separation, the associated sandwich structures are exposed to the QDs. The AgNPs in sandwich structures act as the signaling label of Ade by quenching the fluorescence of QDs (at excitation/emission wavelengths of 370/565 nm) via inner filter effect, electron transfer and trapping processes...
January 27, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29594479/aptamer-based-fluorometric-determination-of-atp-by-exploiting-the-fret-between-carbon-dots-and-graphene-oxide
#19
Xia Cheng, Yao Cen, Guanhong Xu, Fangdi Wei, Menglan Shi, Xiaoman Xu, Muhammad Sohail, Qin Hu
The authors describe a fluorometric aptamer based assay for adenosine triphosphate (ATP). It is based on the use of carbon dots (CDs) and graphene oxide (GO). The resultant CD-aptamer is adsorbed on the surface of GO via π-stacking and hydrophobic interaction, and the fluorescence of CD-aptamer is quenched via fluorescence resonance energy transfer (FRET) between CDs and GO. If ATP is present, it will bind to the aptamer and the CD-aptamer will be desorbed from GO. This will suppress FRET and the fluorescence of the CDs is restored...
January 29, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29569860/maternal-factors-and-preoperative-nutrition-in-children-with-mild-cases-of-congenital-heart-disease
#20
Chunxiang Qin, Ying Li, Dianjun Wang, Zeya Shi, Rui Yao, Dan Wang, Siyuan Tang
AIM: The preoperative poor nutrition of children with congenital heart disease (CHD) impacts the postoperative rehabilitation process of pediatric CHD cases. The factors of these children's preoperative poor nutrition, excluding the disease, have been underreported. The aim was to investigate the preoperative nutritional status of children with CHD who required a simple surgical repair and to analyze the maternal characteristics that are associated with poor nutrition in these sick children...
March 23, 2018: Japan Journal of Nursing Science: JJNS
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