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Second primary, lung cancer

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https://www.readbyqxmd.com/read/29650269/current-perspectives-on-the-crosstalk-between-lung-cancer-stem-cells-and-cancer-associated-fibroblasts
#1
REVIEW
Cristina Alguacil-Núñez, Inés Ferrer-Ortiz, Elena García-Verdú, Pilar López-Pirez, Irene Maria Llorente-Cortijo, Bruno Sainz
Lung cancer, in particular non-small cell lung carcinoma (NSCLC), is the second most common cancer in both men and women and the leading cause of cancer-related deaths worldwide. Its prognosis and diagnosis are determined by several driver mutations and diverse risk factors (e.g. smoking). While immunotherapy has proven effective in some patients, treatment of NSCLC using conventional chemotherapy is largely ineffective. The latter is believed to be due to the existence of a subpopulation of stem-like, highly tumorigenic and chemoresistant cells within the tumor population known as cancer stem cells (CSC)...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29628985/clinical-characteristics-and-prognosis-associated-with-multiple-primary-cancers-in-breast-cancer-patients
#2
Bong Kyun Kim, Se Jeong Oh, Jeong-Yoon Song, Han-Byoel Lee, Min Ho Park, Yongsik Jung, Woo-Chan Park, Jina Lee, Woo Young Sun
Purpose: Breast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs). Methods: Data from the Korean Breast Cancer Society Registry were analyzed...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29623375/ability-of-fdg-pet-and-ct-radiomics-features-to-differentiate-between-primary-and-metastatic-lung-lesions
#3
Margarita Kirienko, Luca Cozzi, Alexia Rossi, Emanuele Voulaz, Lidija Antunovic, Antonella Fogliata, Arturo Chiti, Martina Sollini
PURPOSE: To evaluate the ability of CT and PET radiomics features to classify lung lesions as primary or metastatic, and secondly to differentiate histological subtypes of primary lung cancers. METHODS: A cohort of 534 patients with lung lesions were retrospectively studied. Radiomics texture features were extracted using the LIFEx package from semiautomatically segmented PET and CT images. Histology data were recorded in all patients. The patient cohort was divided into a training and a validation group and linear discriminant analysis (LDA) was performed to classify the lesions using both direct and backward stepwise methods...
April 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29607183/predictive-value-of-pulmonary-function-measures-for-short-term-outcomes-following-lung-resection-analysis-of-a-single-high-volume-institution
#4
Lauren J Taylor, Walker A Julliard, James D Maloney
Despite the importance of preoperative risk-stratification, there is a lack of consensus on how to identify high-risk patients for pulmonary resection. Enrollment criteria for national trials propose one definition based on preoperative pulmonary function tests. We sought to examine the value of preoperative forced expiratory volume in 1 second (FEV1) and diffusion capacity for carbon monoxide (DLCO) to predict short-term outcomes following pulmonary resection. Using our institutional Society of Thoracic Surgeons (STS) database we identified 419 consecutive lung cancer patients who presented to our institution for pulmonary resection between 2012 and 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29605599/does-repeated-surgery-for-recurrent-colo-rectal-lung-metastases-results-in-improved-survival
#5
Cecilia Menna, Giammauro Berardi, Simone Maria Tierno, Claudio Andreetti, Giulio Maurizi, Anna Maria Ciccone, Antonio D'Andrilli, Francesco Cassiano, Camilla Poggi, Daniele Diso, Federico Venuta, Erino Angelo Rendina, Mohsen Ibrahim
BACKGROUND: Lung metastases occur in 10-20% of patients with colorectal cancer (CRC). Lung metastatic pathways of CRC is poorly known and the optimal management for recurrent lung metastases remains uncertain. METHODS: Long-term oncological outcomes of 203 patients with CRC lung metastases who underwent metastasectomy were investigated in this multicentre retrospective study. Ninety-two (45.3%) patients with tumour relapse underwent repeated metastasectomy and 11 (5...
March 29, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29594227/sites-of-recurrent-disease-and-prognostic-factors-in-sclc-patients-treated-with-radiochemotherapy
#6
Rebecca Bütof, Calogero Gumina, Chiara Valentini, Antje Sommerer, Steffen Appold, Daniel Zips, Steffen Löck, Michael Baumann, Esther G C Troost
Objectives: Concurrent radiochemotherapy (RCHT) is standard treatment in locally advanced small cell lung cancer (SCLC) patients. Due to conflicting results on elective nodal irradiation (ENI) or selective node irradiation (SNI) there is no clear evidence on optimal target volumes. Therefore, the purposes of this study were to assess the sites of recurrent disease in SCLC and to evaluate the feasibility of SNI versus ENI. Methods: A retrospective single-institution study of 43 consecutive patients treated with RCHT was performed...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29575839/-clinicopathological-features-of-second-primary-lung-cancer-and-pulmonary-metastasisin-patients-with-breast-cancer
#7
K W He, W Wei, Z Y Liu, X Song, P Y Zhuo, Q H Ma, Z Y Yu
Objective: To compare the clinicopathological characteristics of second primary lung cancer following breast cancer and lung metastases from breast cancer, and then to analyze the risk factors in breast cancer patients with second primary lung tumor. Methods: Clinical data of 55 breast cancer patients with second primary lung tumor and 205 breast cancer patients with solitary pulmonary metastasis in Shandong Cancer Hospital from January 2006 to January 2017 were retrospectively analyzed. The risk factors of primary lung cancer following breast cancer were analyzed using logistic regression model...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29568985/organ-specific-metastasis-of-breast-cancer-molecular-and-cellular-mechanisms-underlying-lung-metastasis
#8
REVIEW
Meysam Yousefi, Rahim Nosrati, Arash Salmaninejad, Sadegh Dehghani, Alireza Shahryari, Alihossein Saberi
BACKGROUND: Breast cancer (BC) is the most common type of cancer in women and the second cause of cancer-related mortality world-wide. The majority of BC-related deaths is due to metastasis. Bone, lung, brain and liver are the primary target sites of BC metastasis. The clinical implications and mechanisms underlying bone metastasis have been reviewed before. Given the fact that BC lung metastasis (BCLM) usually produces symptoms only after the lungs have been vastly occupied with metastatic tumor masses, it is of paramount importance for diagnostic and prognostic, as well as therapeutic purposes to comprehend the molecular and cellular mechanisms underlying BCLM...
April 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29559559/anaplastic-lymphoma-kinase-mutation-alk-f1174c-in-small-cell-carcinoma-of-the-prostate-and-molecular-response-to-alectinib
#9
Benedito A Carneiro, Sahithi Pamarthy, Ami N Shah, Vinay Sagar, Kenji Unno, HuiYing Han, Ximing J Yang, Rubens B Costa, Rebecca J Nagy, Richard B Lanman, Timothy M Kuzel, Jeffrey S Ross, Laurie Gay, Julia A Elvin, Siraj M Ali, Massimo Cristofanilli, Young Kwang Chae, Francis J Giles, Sarki A Abdulkadir
PURPOSE: Small cell carcinoma of the prostate (SCCP) is an aggressive disease that can arise de novo or by transdifferentiation from prostate adenocarcinoma. Alterations in anaplastic lymphoma kinase (ALK) gene are involved in neuroblastoma, lung cancer, and other malignancies but its role in SCCP has not been documented. We describe a patient with refractory de novo SCCP with ALK F1174C activating mutation who obtained clinical benefit from treatment with ALK inhibitor. EXPERIMENTAL DESIGN: Next-generation sequencing (NGS) was used to analyze primary and circulating tumor DNA (ctDNA)...
March 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29555258/modified-xeliri-capecitabine-plus-irinotecan-versus-folfiri-leucovorin-fluorouracil-and-irinotecan-both-either-with-or-without-bevacizumab-as-second-line-therapy-for-metastatic-colorectal-cancer-axept-a-multicentre-open-label-randomised-non-inferiority-phase
#10
Rui-Hua Xu, Kei Muro, Satoshi Morita, Satoru Iwasa, Sae Won Han, Wei Wang, Masahito Kotaka, Masato Nakamura, Joong Bae Ahn, Yan-Hong Deng, Takeshi Kato, Sang-Hee Cho, Yi Ba, Hiroshi Matsuoka, Keun-Wook Lee, Tao Zhang, Yasuhide Yamada, Junichi Sakamoto, Young Suk Park, Tae Won Kim
BACKGROUND: Studies of a modified XELIRI (mXELIRI; capecitabine plus irinotecan) regimen suggest promising efficacy and tolerability profiles in the first-line and second-line settings. Therefore, we aimed to compare the efficacy and safety of the mXELIRI regimen with that of standard FOLFIRI (leucovorin, fluorouracil, and irinotecan), with or without bevacizumab in both regimens, as a second-line therapy for metastatic colorectal cancer. METHODS: We did a multicentre, open-label, randomised, non-inferiority, phase 3 trial...
March 16, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29550245/european-organisation-for-research-and-treatment-of-cancer-soft-tissue-and-bone-sarcoma-group-experience-with-advanced-metastatic-epithelioid-sarcoma-patients-treated-in-prospective-trials-clinical-profile-and-response-to-systemic-therapy
#11
N Touati, P Schöffski, S Litière, I Judson, S Sleijfer, W T van der Graaf, A Italiano, N Isambert, T Gil, J Y Blay, D Stark, T Brodowicz, S Marréaud, A Gronchi
AIMS: Epithelioid sarcoma is a soft tissue sarcoma associated with a high rate of local recurrence after wide resection and high incidence of distant metastasis. Little is known about the clinical course and response to systemic treatments in epithelioid sarcoma patients. We carried out a retrospective analysis of clinical data from epithelioid sarcoma patients to provide a reference for the design of future epithelioid sarcoma-specific studies. PATIENTS AND METHODS: Data from patients with epithelioid sarcoma entered in prospective multi-sarcoma phase II/III trials were pooled: EORTC trial 62012 (doxorubicin versus doxorubicin/ifosfamide), 62043 (pazopanib), 62072 (pazopanib versus placebo) and 62091 (doxorubicin versus trabectedin)...
March 15, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29531906/the-risk-of-second-primary-lung-cancer-an-unsolved-dilemma
#12
EDITORIAL
Antoinette J Wozniak, Ann G Schwartz
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531899/can-population-data-guide-surveillance-strategies-for-second-primary-lung-cancers
#13
EDITORIAL
Andrew J Arifin, Mark T Corkum, Alexander V Louie
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29528793/randomized-double-blind-placebo-controlled-multicenter-phase-ii-study-of-fruquintinib-after-two-prior-chemotherapy-regimens-in-chinese-patients-with-advanced-nonsquamous-non%C3%A2-small-cell-lung-cancer
#14
Shun Lu, Jianhua Chang, Xiaoqing Liu, Jianhua Shi, You Lu, Wei Li, Jin-Ji Yang, Jianying Zhou, Jie Wang, Tongtong An, Lei Yang, Zhe Liu, Xiangdong Zhou, Mo Chen, Ye Hua, Weiguo Su
Purpose Patients with advanced non‒small-cell lung cancer (NSCLC) who fail two lines of chemotherapy have unmet medical needs. The kinase inhibitor fruquintinib selectively targets vascular endothelial growth factor receptors and, hence, tumor angiogenesis and lymphogenesis. This randomized, double-blind, placebo-controlled, multicenter phase II trial evaluated the efficacy and safety of fruquintinib in patients with advanced nonsquamous NSCLC who experienced disease progression after second-line chemotherapy...
March 12, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29520523/type-of-second-primary-malignancy-after-achieving-complete-response-by-definitive-chemoradiation-therapy-in-patients-with-esophageal-squamous-cell-carcinoma
#15
Toshifumi Yamaguchi, Ken Kato, Kengo Nagashima, Satoru Iwasa, Yoshitaka Honma, Atsuo Takashima, Tetsuya Hamaguchi, Yoshinori Ito, Jun Itami, Narikazu Boku, Kazuhide Higuchi
BACKGROUND: While the standard treatment for stage II-III (non-T4) esophageal squamous cell carcinoma (ESCC) is neoadjuvant therapy followed by esophagectomy, definitive chemoradiation therapy (dCRT) is an option to treat ESCC patients who reject or may not tolerate surgical treatment. Second primary malignancy (SPM) is a problem for long-term survivors after achieving complete response (CR) by dCRT. METHODS: The source of the subjects in this study was the patients with stage II/III (excluding T4 disease) ESCC (UICC6th) who underwent dCRT from 2000 to 2011 at the National Cancer Center Hospital, Japan...
March 8, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29518055/marine-bacterial-polysaccharide-eps11-inhibits-cancer-cell-growth-via-blocking-cell-adhesion-and-stimulating-anoikis
#16
Ruobing Cao, Weihua Jin, Yeqi Shan, Ju Wang, Ge Liu, Shan Kuang, Chaomin Sun
Tumor cells that acquire metastatic potential have developed resistance to anoikis, a cell death process, after detachment from their primary site to the second organ. In this study, we investigated the molecular mechanisms of a novel marine bacterial polysaccharide EPS11 which exerts its cytotoxic effects through affecting cancer cell adhesion and anoikis. Firstly, we found that EPS11 could significantly affect cell proliferation and block cell adhesion in A549 cells. We further demonstrated that the expression of several cell adhesion associated proteins is downregulated and the filiform structures of cancer cells are destroyed after EPS11 treatment...
March 8, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29516976/meta-analysis-of-adjuvant-chemotherapy-versus-surgery-alone-in-t2an0-stage-ib-non-small-cell-lung-cancer
#17
Tianxiang Zhang, Qiang Guo, Ye Zhang, Zhidong Liu, Shijie Zhou, Shaofa Xu
Background: Although there is a strong evidence that adjuvant chemotherapy after surgery was effective in Stages II and IIIA patients involved nonsmall cell lung cancer (NSCLC), its eligibility in Stage IB disease has been unknown. Therefore, this meta-analysis was aimed to compare the effects of adjuvant chemotherapy versus surgery alone in patients with Stage IB NSCLC. Materials and Methods: We systematically searched for articles from their inclusion to July 2016...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29511939/hepatectomy-for-oligo-recurrence-of-non-small-cell-lung-cancer-in-the-liver
#18
Fumitaka Ishige, Wataru Takayama, Satoshi Chiba, Isamu Hoshino, Hidehito Arimitsu, Hiroo Yanagibashi, Yosuke Iwatate
BACKGROUND: The prognosis of metastatic recurrent non-small cell lung cancer (NSCLC) is poor, and chemotherapy improves survival by only a few months. The concept of oligo-recurrence, defined as a small number of new lesions at a distant site theoretically curable by local therapy, has recently been proposed for several cancers. To evaluate the possible benefits of surgical resection for oligo-recurrence, we report the outcomes of seven patients who underwent hepatic resection for oligo-recurrence of NSCLC in the liver...
March 6, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29502152/adjuvant-vinorelbine-and-cisplatin-after-complete-resection-of-stage-ii-and-iii-non-small-cell-lung-cancer-long-term-follow-up-of-our-study-of-japanese-patients
#19
Makoto Sonobe, Masatsugu Hamaji, Hideki Motoyama, Toshi Menju, Akihiro Aoyama, Toyofumi F Chen-Yoshikawa, Toshihiko Sato, Hiroshi Date
PURPOSE: We reported previously a phase II study of adjuvant chemotherapy consisting of four cycles of vinorelbine (25 mg/m2 ) and cisplatin (40 mg/m2 ), given on days 1 and 8, every 4 weeks, to Japanese patients with completely resected stage II or III non-small cell lung cancer (NSCLC; UMIN 000005055). However, the follow-up was too short for us to evaluate a definitive 5-year overall survival rate and after-effects. METHODS: Between December 2006 and January 2011, 60 patients were enrolled in this study...
March 3, 2018: Surgery Today
https://www.readbyqxmd.com/read/29493103/metastatic-hepatocellular-carcinoma-diagnosed-by-fine-needle-aspiration-a-clinical-and-cytologic-study
#20
Lei Yan, Shriram Jakate, Vijaya Reddy, Paolo Gattuso
BACKGROUND: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide. The clinical and cytological features of metastatic HCC have not been well established. METHODS: To determine the clinical and cytological features of metastatic HCC, we retrospectively searched for all HCC metastasis diagnosed by fine needle aspiration or core biopsy. RESULTS: We found 12 bone metastases, 11 intra-abdominal, 4 lung, 3 soft tissue, and 2 lymph node metastases from 32 patients...
March 1, 2018: Diagnostic Cytopathology
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