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https://www.readbyqxmd.com/read/29322610/safety-and-efficacy-of-once-weekly-semaglutide-versus-additional-oral-antidiabetic-drugs-in-japanese-subjects-with-inadequately-controlled-t2d-a-randomised-trial
#1
Kohei Kaku, Yuichiro Yamada, Hirotaka Watada, Atsuko Abiko, Tomoyuki Nishida, Jeppe Zacho, Arihiro Kiyosue
AIMS: Semaglutide is a glucagon-like peptide 1 analogue in development for type 2 diabetes (T2D). Safety and efficacy of once-weekly subcutaneous semaglutide as monotherapy or combined with an oral antidiabetic drug (OAD) vs an additional OAD was evaluated in Japanese subjects with T2D inadequately controlled on diet/exercise or OAD monotherapy. METHODS: In this phase 3, open-label trial, adults with T2D were randomised 2:2:1 to semaglutide 0.5 mg or 1.0 mg, or one additional OAD (dipeptidyl peptidase-4 inhibitor, biguanide, sulphonylurea, glinide, α-glucosidase inhibitor or thiazolidinedione) with different modes of action...
January 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29319785/diagnostic-accuracy-and-prognostic-value-of-simultaneous-hybrid-18f-fluorodeoxyglucose-positron-emission-tomography-magnetic-resonance-imaging-in-cardiac-sarcoidosis
#2
Eleanor C Wicks, Leon J Menezes, Anna Barnes, Saidi A Mohiddin, Neha Sekhri, Joanna C Porter, Helen L Booth, Emily Garrett, Riyaz S Patel, Menelaos Pavlou, Ashley M Groves, Perry M Elliott
Aims: Cardiac death is the leading cause of mortality in patients with sarcoidosis, yet cardiac involvement often remains undetected. Cardiovascular magnetic resonance imaging (CMR) and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) have been used to diagnose cardiac sarcoidosis (CS) yet never simultaneously in a cohort. This study sought to assess the diagnostic and prognostic utility of simultaneous hybrid cardiac PET/MR. Methods and results: Fifty-one consecutive patients with suspected CS (age 50 ± 13 years, 31 males) underwent simultaneous PET/MR following a high-fat/low-carbohydrate diet and 12-h fast...
January 8, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29290357/glycemic-index-and-glycemic-load-of-the-diets-of-japanese-adults-the-2012-national-health-and-nutrition-survey-japan
#3
Kentaro Murakami, Satoshi Sasaki
OBJECTIVE: The aim of this study was to examine the dietary glycemic index (GI) and glycemic load (GL) of Japanese adults, as well as their nutritional correlates, in the 2012 National Health and Nutrition Survey, Japan. METHOD: Dietary data from 15 618 adults aged ≥20 y, collected using a 1-d weighed dietary record, were analyzed. The GI of foods was assigned based on a stepwise published strategy using values from common GI databases. RESULTS: Mean (SD) dietary GI and GL were 65...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29278547/fenofibrate-attenuates-cardiac-and-renal-alterations-in-young-salt-loaded-spontaneously-hypertensive-stroke-prone-rats-through-mitochondrial-protection
#4
Laura Castiglioni, Alice Pignieri, Melania Fiaschè, Marco Giudici, Maurizio Crestani, Nico Mitro, Mauro Abbate, Carlamaria Zoja, Daniela Rottoli, Claudia Foray, Fabio Fiordaliso, Uliano Guerrini, Elena Tremoli, Luigi Sironi, Paolo Gelosa
OBJECTIVES: The simultaneous presence of cardiac and renal diseases is a pathological condition that leads to increased morbidity and mortality. Several lines of evidence have suggested that lipid dysmetabolism and mitochondrial dysfunction are pathways involved in the pathological processes affecting the heart and kidney. In the salt-loaded spontaneously hypertensive stroke-prone rat (SHRSP), a model of cardiac hypertrophy and nephropathy that shows mitochondrial alterations in the myocardium, we evaluated the cardiorenal effects of fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist that acts by modulating mitochondrial and peroxisomal fatty acid oxidation...
December 22, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29278280/texture-modified-diets-are-associated-with-decreased-muscle-mass-in-older-adults-admitted-to-a-rehabilitation-ward
#5
Akio Shimizu, Keisuke Maeda, Kei Tanaka, Mei Ogawa, Jun Kayashita
AIM: Texture-modified diets (TMD) have significantly lower energy and protein content than normal diets. Therefore, TMD can cause malnutrition and loss of muscle mass. However, few studies have reported the relationship between TMD and decreased skeletal muscle mass. The aim of the present study was to clarify the association between TMD and decreased skeletal muscle mass. METHODS: We reviewed data of 188 older adult patients who were admitted to a rehabilitation hospital...
December 26, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29222887/relationship-between-umami-taste-acuity-with-sweet-or-bitter-taste-acuity-and-food-selection-in-japanese-women-university-students
#6
Masaru Kubota, Chikako Toda, Ayako Nagai-Moriyama
BACKGROUND AND OBJECTIVES: Although there are many studies on the umami receptor and its signaling pathway, literature on the effect of umami taste acuity on dietary choices in healthy subjects is limited. The current study aims to clarify the relationship between umami taste acuity with sweet or bitter taste acuity, food preference and intake. METHODS AND STUDY DESIGN: Forty-two healthy Japanese female university students were enrolled. The acuity for umami, sweet, and bitter tastes was evaluated using the filter-paper disc method...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222610/characterizing-the-neighborhood-obesogenic-environment-in-the-multiethnic-cohort-a-multi-level-infrastructure-for-cancer-health-disparities-research
#7
Shannon M Conroy, Salma Shariff-Marco, Juan Yang, Andrew Hertz, Myles Cockburn, Yurii B Shvetsov, Christina A Clarke, Cheryl L Abright, Christopher A Haiman, Loïc Le Marchand, Laurence N Kolonel, Kristine R Monroe, Lynne R Wilkens, Scarlett Lin Gomez, Iona Cheng
PURPOSE: We characterized the neighborhood obesogenic environment in the Multiethnic Cohort (MEC) by examining the associations of obesity with attributes of the social and built environment, establishing a multi-level infrastructure for future cancer research. METHODS: For 102,906 African American, Japanese American, Latino, and white MEC participants residing predominately in Los Angeles County, baseline residential addresses (1993-1996) were linked to census and geospatial data, capturing neighborhood socioeconomic status (nSES), population density, commuting, food outlets, amenities, walkability, and traffic density...
December 8, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29207502/relationship-between-vitamin-intake-and-depressive-symptoms-in-elderly-japanese-individuals-differences-with-gender-and-body-mass-index
#8
Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Yasuhiro Kambayashi, Akinori Hara, Sakae Miyagi, Yohei Yamada, Haruki Nakamura, Yukari Shimizu, Daisuke Hori, Fumihiko Suzuki, Koichiro Hayashi, Hiroyuki Nakamura
Only a few studies have focused on the relationship between vitamin intake and depressive symptoms in Japanese individuals. This cross-sectional study investigated the relationship between vitamin intake and depressive symptoms in 1634 elderly Japanese individuals (65 years and older). The consumption of fifteen vitamins including retinol, a retinol equivalent, beta-carotene equivalent, vitamin D, alpha-tocopherol, vitamin K, vitamin group B, vitamin C, and cryptoxanthine was analyzed using a brief-type self-administered diet history questionnaire (BDHQ)...
December 3, 2017: Nutrients
https://www.readbyqxmd.com/read/29183766/ketogenic-diet-using-a-japanese-ketogenic-milk-for-patients-with-epilepsy-a-multi-institutional-study
#9
Tomohiro Kumada, Katsumi Imai, Yukitoshi Takahashi, Shin Nabatame, Hirokazu Oguni
BACKGROUND: In Japan, Meiji 817-B (M817-B), a powdered ketogenic milk, has been available since the ketogenic diet was introduced to infants and tube-fed children with medication-resistant epilepsy in the 1980s. METHODS: We retrospectively evaluated the efficacy, tolerability, and side effects of the ketogenic diet using M817-B as the main source of daily food intake for patients with epilepsy by sending questionnaires to the members of a subcommittee of the Japan Epilepsy Society that focuses on the proper use of M817-B...
November 25, 2017: Brain & Development
https://www.readbyqxmd.com/read/29183576/geranium-intoxication-induces-detoxification-enzymes-in-the-japanese-beetle-popillia-japonica-newman
#10
Adekunle W Adesanya, David W Held, Nannan Liu
Popillia japonica is a generalist herbivore that feeds on >300 host plant species in at least 72 plant families. It is unknown why P. japonica, despite possessing active detoxification enzymes in its gut, is paralyzed when feeding on the petals of one of its preferred host plant, Pelargonium×hortorum, or on artificial diet containing quisqualic acid (QA), the active compound in zonal geranium. We hypothesized that Pelargonium×hortorum or QA do not induce activity of the cytochrome P450, glutathione S transferase (GST), and carboxylesterase (CoE) detoxification enzymes in P...
November 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29181821/combination-effects-of-organic-and-inorganic-chromium-on-production-performance-reproductive-response-immune-status-and-maternal-antibody-transmission-in-breeder-quails-under-heat-stress
#11
A Gitoee, Gh Sadeghi, A Karimi
This experiment was carried out to investigate the combination effects of organic and inorganic chromium (Cr) on egg production, egg quality, reproductive response, and immune status of breeder quails and their offspring under heat stress. A total of 140 7-week-old Japanese breeder quails (120 females and 20 males) according to a completely randomized design were used in four treatment groups (five replicate and seven birds per each) lasted for 8 weeks. Quails exposed to 35 °C for 8 h/day for induction of cyclic heat stress treatments consisted of diets supplemented with (1) 1 mg CrCl3 per kilogram of diet as control (CNT); (2) 1 mg Cr-L-Met per kilogram of diet as organic Cr (OCr); (3) 0...
November 27, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29181660/pre-operative-and-post-operative-estimated-glomerular-filtration-rate-in-japanese-patients-with-urological-malignancies
#12
Naoya Niwa, Tadashi Yoshida, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Matsuhiko Hayashi, Mototsugu Oya
BACKGROUND: The suitable methods evaluating glomerular filtration rate (GFR) have not been established in patients undergoing radical nephrectomy (RN) or radical nephroureterectomy (RNU) due to urological malignancies in Japan as well as worldwide. METHODS: We examined the relationship between creatinine clearance-based measured GFR (mGFR) versus estimated GFR (eGFR) calculated by 3 popular equations, 4-variable Modification of Diet in Renal Disease equation adjusted by Japanese correction coefficient (cmMDRD), 3-variable MDRD equation for Japanese population (eGFRcreat), and Chronic Kidney Disease-Epidemiology Collaboration equation adjusted by Japanese correction coefficient (cmCKD-EPI) in Japanese patients who had undergone RN or RNU due to renal cell carcinoma or upper tract urothelial carcinoma before and after surgery...
November 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29160184/awareness-use-and-information-sources-of-folic-acid-supplementation-to-prevent-neural-tube-defects-in-pregnant-japanese-women
#13
Shumi Yamamoto, Yoshinao Wada
OBJECTIVE: Folic acid supplementation and folate-rich diets are recommended for women of childbearing age worldwide to prevent congenital anomalies. We aimed to determine the current status of folic acid supplementation among pregnant Japanese women and identify means to increase the intake of these supplements. DESIGN: Cross-sectional study. SUBJECTS: A total of 1862 pregnant women who consulted the perinatal centre from September 2014 to December 2015 completed a questionnaire concerning knowledge about folic acid, sources of information and the use of folic acid supplements...
November 21, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29158425/improving-metabolic-health-through-precision-dietetics-in-mice
#14
William T Barrington, Phillip Wulfridge, Ann E Wells, Carolina Mantilla Rojas, Selene Y F Howe, Amie Perry, Kunjie Hua, Michael A Pellizzon, Kasper D Hansen, Brynn H Voy, Brian J Bennett, Daniel Pomp, Andrew P Feinberg, David W Threadgill
The incidence of diet-induced metabolic disease has soared the last half-century despite national efforts to improve health through universal dietary recommendations. Studies comparing dietary patterns of populations with health outcomes have historically provided the basis for healthy diet recommendations. However, evidence that population-level diet responses are reliable indicators of responses across individuals is lacking.  This study investigated how genetic differences influence health responses to several popular diets in mice, which are similar to humans in genetic composition and propensity to develop metabolic disease, but enable precise genetic and environmental control...
November 20, 2017: Genetics
https://www.readbyqxmd.com/read/29145277/tricho-hepato-enteric-syndrome-with-novel-skiv2l-gene-mutations-a-case-report
#15
Eitaro Hiejima, Takahiro Yasumi, Hiroshi Nakase, Minoru Matsuura, Yusuke Honzawa, Hirokazu Higuchi, Ikuo Okafuji, Tohru Yorifuji, Takayuki Tanaka, Kazushi Izawa, Tomoki Kawai, Ryuta Nishikomori, Toshio Heike
RATIONALE: Tricho-hepato-enteric syndrome (THES) is a rare disorder caused by mutations in the TTC37 or SKIV2L genes and characterized by chronic diarrhea, liver disease, hair abnormalities, and high mortality in early childhood due to severe infection or liver cirrhosis. PATIENT CONCERNS: The patient is the second child of three siblings born to non-consanguineous healthy Japanese parents. She had intrauterine growth retardation and was delivered at 33 weeks of gestation due to placental abruption...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143690/standardisation-of-the-japanese-diet-for-use-in-animal-experiments
#16
Saeko Sugawara, Yui Mizowaki, Yui Iwagaki, Yu Sakamoto, Kazushi Yamamoto, Tsuyoshi Tsuduki
The aim of this study was to develop a purified diet that mimics the characteristics of the Japanese diet using readily available materials with a simpler composition and a focus on quality, with the goal of facilitating performance of studies on the Japanese diet worldwide. The utility of the new diet was examined as a mimic of the standard Japanese diet for use in animal experiments. We examined whether a key characteristic of the Japanese diet of being less likely to cause obesity could be reproduced. The mimic diet had a balance of protein, fat and carbohydrate based on the 1975 Japanese diet, which is the least likely to cause obesity, and materials chosen with reference to the National Health and Nutrition Survey (NHNS)...
November 16, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29109757/evaluation-of-the-efficacy-of-ajuga-decumbens-extract-supplement-in-individuals-with-knee-discomfort-associated-with-physical-activity-a-randomized-double-blind-placebo-controlled-study
#17
Yoko Sawada, Atsushi Sugimoto, Takehito Hananouchi, Norimasa Sato, Isao Nagaoka
The aim of the present study was to assess the efficacy and safety of the oral administration of Ajuga decumbens extract (ADE) supplement to individuals with knee discomfort associated with physical activity. A randomized, double-blind, placebo-controlled study was conducted using 48 subjects. The subjects were randomly allocated to an ADE diet group (oral administration of ADE-containing diet, n=24) or a placebo group (n=24), and the intervention was conducted for 12 weeks. A total of 22 subjects in the placebo group and 22 subjects in the ADE diet group were assessed to be eligible for assessment of the efficacy of supplement...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29098543/effect-of-chromium-nanoparticles-on-physiological-stress-induced-by-exogenous-dexamethasone-in-japanese-quails
#18
Atefeh Berenjian, Seyed Davood Sharifi, Abdollah Mohammadi-Sangcheshmeh, Shekofeh Ghazanfari
Chromium (Cr), as an essential trace element, plays a critical role in carbohydrate, protein, and lipid metabolism in animals. It has been suggested that the beneficial effects of Cr increase by environmental stresses, which lead to greater Cr effects on stressed animals. The objective of the present study was to evaluate the response of physiologically stressed Japanese quails (Coturnix japonica) to dietary chromium nanoparticle (Nano-Cr) supplementation. The stress was induced by adding dexamethasone (0.6 mg/kg BW) to Japanese quails' diet from 17 to 22 days of age...
November 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29079983/improving-growth-performance-and-health-status-of-meat-type-quail-by-supplementing-the-diet-with-black-cumin-cold-pressed-oil-as-a-natural-alternative-for-antibiotics
#19
Mohamed E Abd El-Hack, Samir A Mahgoub, Mohamed M A Hussein, Islam M Saadeldin
Using antibiotics in poultry diets as growth promoters was reported to have harmful effects on consumers, so the current study was done to monitor the impact of dietary supplementation of antimicrobial black cumin oil (BCO) on carcass traits, growth performance, biochemical components, and ileal microbial populations of growing Japanese quails. Three hundred growing Japanese quails were used with three different treatments (0, 0.50, and 1.0 g BCO/g diet). Birds fed diet supplemented with 0.5 g BCO/kg diet showed significant increase in body weight comparing with the control and other treatment group...
October 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29077959/performance-and-serum-biochemical-profile-of-japanese-quail-supplemented-with-silymarin-and-contaminated-with-aflatoxin-b1
#20
M I Sakamoto, A E Murakami, A M Fernandes, I C Ospina-Rojas, K C Nunes, A K Hirata
The aim of this study was to evaluate the hepatoprotective effect of silymarin in diets contaminated or not with aflatoxin B1 (AFB1) on the productive performance and serum biochemical profile of Japanese quail (Coturnix coturnix japonica) in the laying phase. A total of 240 12-week-old Japanese quail was used in a completely randomized design in a 3 × 2 factorial scheme (additives x contaminated or not with AFB1 - 1,500 μg/kg), totaling 6 treatments and 5 replicates of 8 birds each. The additives used were silymarin (500 g/ton), adsorbent (1 kg/ton), and a control diet (without additive)...
October 25, 2017: Poultry Science
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