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https://www.readbyqxmd.com/read/28921915/weekly-glucagon-like-peptide-1-receptor-agonist-albiglutide-as-monotherapy-improves-glycemic-parameters-in-japanese-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-study
#1
Antonio Nino, Inaha Okuda, Timothy H Wilson, Lin Yue, Hiromu Nakajima, Maho Tsuboi, Molly C Carr, Yutaka Seino
AIMS/INTRODUCTION: This phase 3, randomized, double-blind 24-week study with extension to 1 year assessed efficacy and safety of albiglutide compared with placebo in Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled by diet and exercise with or without a single oral antidiabetic drug. MATERIALS AND METHODS: Patients received weekly albiglutide 30 mg (n=160), albiglutide 50 mg (n=150), or placebo switched to albiglutide 30 mg after 24 weeks (n=77)...
September 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28913773/food-nitrogen-footprint-reductions-related-to-a-balanced-japanese-diet
#2
Azusa Oita, Ichiro Nagano, Hiroyuki Matsuda
Dietary choices largely affect human-induced reactive nitrogen accumulation in the environment and resultant environmental problems. A nitrogen footprint (NF) is an indicator of how an individual's consumption patterns impact nitrogen pollution. Here, we examined the impact of changes in the Japanese diet from 1961 to 2011 and the effect of alternative diets (the recommended protein diet, a pescetarian diet, a low-NF food diet, and a balanced Japanese diet) on the food NF. The annual per capita Japanese food NF has increased by 55% as a result of dietary changes since 1961...
September 14, 2017: Ambio
https://www.readbyqxmd.com/read/28893250/association-between-dietary-patterns-and-cognitive-function-among-70-year-old-japanese-elderly-a-cross-sectional-analysis-of-the-sonic-study
#3
Hitomi Okubo, Hiroki Inagaki, Yasuyuki Gondo, Kei Kamide, Kazunori Ikebe, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Satoshi Sasaki, Takeshi Nakagawa, Mai Kabayama, Ken Sugimoto, Hiromi Rakugi, Yoshinobu Maeda
BACKGROUND: An increasing number of studies in Western countries have shown that healthy dietary patterns may have a protective effect against cognitive decline and dementia. However, information on this relationship among non-Western populations with different cultural settings is extremely limited. We aim to examine the relationship between dietary patterns and cognitive function among older Japanese people. METHODS: This cross-sectional study included 635 community-dwelling people aged 69-71 years who participated in the prospective cohort study titled Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC)...
September 11, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28875870/a-priori-defined-diet-quality-indices-biomarkers-and-risk-for-type-2-diabetes-in-five-ethnic-groups-the-multiethnic-cohort
#4
Simone Jacobs, Carol J Boushey, Adrian A Franke, Yurii B Shvetsov, Kristine R Monroe, Christopher A Haiman, Laurence N Kolonel, Loic Le Marchand, Gertraud Maskarinec
Dietary indices have been related to risk for type 2 diabetes (T2D) predominantly in white populations. The present study evaluated this association in the ethnically diverse Multiethnic Cohort and examined four diet quality indices in relation to T2D risk, homoeostatic model assessment-estimated insulin resistance (HOMA-IR) and biomarkers of dyslipidaemia, inflammation and adipokines. The T2D analysis included 166 550 white, African American, Native Hawaiian, Japanese American and Latino participants (9200 incident T2D cases)...
August 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28870472/effects-of-high-%C3%AE-glucan-barley-on-visceral-fat-obesity-in-japanese-individuals-a-randomized-double-blind-study
#5
Seiichiro Aoe, Yasunori Ichinose, Noriko Kohyama, Kozo Komae, Asuka Takahashi, Daigo Abe, Toji Yoshioka, Takashi Yanagisawa
OBJECTIVE: The aim of this study was to investigate whether a diet in which high β-glucan barley was substituted for rice would reduce visceral fat obesity in Japanese individuals. METHODS: A randomized, double-blind, placebo-controlled intervention study was conducted with 100 Japanese individuals with waist circumference (WC) ≥85 cm for men or ≥90 cm for women and body mass index (BMI) ≥24 kg/m(2). Participants were randomly assigned to consume a mixture of rice and either high β-glucan barley (test group, 4...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28869909/dietary-patterns-and-depressive-symptoms-during-pregnancy-in-japan-baseline-data-from-the-kyushu-okinawa-maternal-and-child-health-study
#6
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa
BACKGROUND: Only one Brazilian study has examined the association between dietary patterns and depressive symptoms during pregnancy. The current cross-sectional study examined this issue in Japan. METHODS: Study subjects were 1744 pregnant women. Between April 2007 and March 2008, information under study was obtained. Dietary patterns were derived from a factor analysis of 33 predefined food groups based on a self-administered diet history questionnaire. Depressive symptoms were defined as a Center for Epidemiological Studies Depression Scale score ≥ 16...
August 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28856459/the-criteria-of-thickened-liquid-for-dysphagia-management-in-japan
#7
Emi Watanabe, Yoshie Yamagata, Junko Fujitani, Ichiro Fujishima, Koji Takahashi, Risa Uyama, Hiro Ogoshi, Akiko Kojo, Hiroshi Maeda, Koichiro Ueda, Jun Kayashita
In Japan, the viscosity of thickened liquids is different among hospitals and nursing homes. In order to standardize viscosity of thickened liquids, the dysphagia diet committee of the Japanese Society of Dysphagia Rehabilitation developed the Japanese Dysphagia Diet 2013 (JDD2013). To decide on a definition of thickened liquids, the committee reviewed categories from other countries. Especially, the criteria of the USA and Australia were used as references. The definition had three levels: mildly thick, moderately thick, and extremely thick...
August 30, 2017: Dysphagia
https://www.readbyqxmd.com/read/28851478/household-income-is-associated-with-food-and-nutrient-intake-in-japanese-schoolchildren-especially-on-days-without-school-lunch
#8
Nobuko Murayama, Hiromi Ishida, Taeko Yamamoto, Sayaka Hazano, Akemi Nakanishi, Yumi Arai, Miho Nozue, Yukiko Yoshioka, Saori Saito, Aya Abe
OBJECTIVE: The present study aimed to examine the association between household income and the intake of foods and nutrients by Japanese schoolchildren, and any differences between days with and without school lunch. DESIGN: This was a cross-sectional study. Children, with the support of their parents, kept dietary records with photographs for 4 d (2 d with school lunch and 2 d without). The socio-economic status of each family was obtained from a questionnaire completed by the parents...
August 30, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28842914/metabolic-conditions-and-breast-cancer-risk-among-los-angeles-county-filipina-americans-compared-with-chinese-and-japanese-americans
#9
Anna H Wu, Cheryl Vigen, Lesley M Butler, Chiu-Chen Tseng
Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes, dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these metabolic conditions contribute to breast cancer risk in certain Asian American subgroups is unknown. We investigated the role of physician-diagnosed hypertension, high cholesterol, and diabetes separately, and in combination, in relation to the risk of breast cancer in a population-based case-control study of 2,167 Asian Americans diagnosed with breast cancer and 2,035 age and ethnicity matched control women in Los Angeles County...
August 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28836351/efficacy-and-safety-of-once-weekly-oral-trelagliptin-switched-from-once-daily-dipeptidyl-peptidase-4-inhibitor-in-patients-with-type-2-diabetes-mellitus-an-open-label-phase-3-exploratory-study
#10
Nobuya Inagaki, Hiroki Sano, Yoshifumi Seki, Shingo Kuroda, Kohei Kaku
INTRODUCTION: Trelagliptin, a novel once-weekly oral dipeptidyl peptidase-4 (DPP-4) inhibitor, has shown favorable efficacy and safety in type 2 diabetes mellitus (T2DM) patients. Trelagliptin was launched in Japan and is expected to be initially used for switchover from a daily DPP-4 inhibitor in the clinical setting. Thus, this study was planned to explore the efficacy and safety of trelagliptin after a daily DPP-4 inhibitor was switched to it. MATERIALS AND METHODS: This was an open-label phase 3 exploratory study to evaluate the efficacy and safety of trelagliptin in Japanese T2DM patients who had stable glycemic control on once-daily sitagliptin therapy...
August 24, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28834090/identification-of-characteristic-components-and-foodstuffs-in-healthy-japanese-diet-and-the-health-effects-of-a-diet-with-increased-use-frequency-of-these-foodstuffs
#11
Yui Iwagaki, Yu Sakamoto, Saeko Sugawara, Yui Mizowaki, Kazushi Yamamoto, Tatsuya Sugawara, Kazuhiko Kimura, Tsuyoshi Tsuduki
SCOPE: Our recent study showed that the 1975 Japanese diet exhibited strong health benefits. In the current study, we aimed to develop a diet with even higher health benefits. METHODS: First, to determine the characteristic components in the 1975 diet, we used mass spectrometry for analysis of Japanese diets from several years and performed principal component analysis. Next, a diet with an increased use frequency of foodstuffs contained characteristic components (the modified diet) was prepared and fed to mice...
August 22, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28833849/fifty-years-of-child-height-and-weight-in-japan-and-south-korea-contrasting-secular-trend-patterns-analyzed-by-sitar
#12
T J Cole, H Mori
Objectives Japanese and South Koreans have traditionally been shorter than Europeans, but have recently become appreciably taller. The aim was to quantify the secular trend patterns in height and weight growth in the two countries over 50 years using the SITAR growth curve model. Methods Data on mean height and weight by sex in 1-year age groups from 1 to 20 years were obtained by decade in South Korea (1965-2005) and Japan (1950-2010). The data were analyzed using SITAR (SuperImposition by Translation And Rotation), which estimates a mean curve and three adjustments-size, timing and intensity-reflecting how the individual surveys differ from the mean...
August 23, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28817589/relationship-between-atherosclerosis-and-occlusal-support-of-natural-teeth-with-mediating-effect-of-atheroprotective-nutrients-from-the-sonic-study
#13
Sayaka Tada, Kazunori Ikebe, Kei Kamide, Yasuyuki Gondo, Chisato Inomata, Hajime Takeshita, Ken-Ich Matsuda, Masahiro Kitamura, Shinya Murakami, Mai Kabayama, Ryousuke Oguro, Chikako Nakama, Tatsuo Kawai, Koichi Yamamoto, Ken Sugimoto, Ayumi Shintani, Takuma Ishihara, Yasumichi Arai, Yukie Masui, Ryutaro Takahashi, Hiromi Rakugi, Yoshinobu Maeda
Whereas most of studies investigating relationship between oral health and atherosclerosis have focused on periodontitis, very few of them were examined about occlusal status of natural teeth which possibly influence dietary habit. The primary aim of this cross-sectional study was to investigate the association between the occlusal support of posterior teeth and the prevalence of atherosclerosis in community-dwelling septuagenarians. Also, the second aim was to test the hypothesis that the intake of key nutrients for atherosclerosis prevention would have a mediating effect on the relationship between the occlusal status and atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28811858/effectiveness-of-ipragliflozin-for-reducing-hemoglobin-a1c-in-patients-with-a-shorter-type-2-diabetes-duration-interim-report-of-the-assign-k-study
#14
Kotaro Iemitsu, Takehiro Kawata, Takashi Iizuka, Masahiro Takihata, Masahiko Takai, Shigeru Nakajima, Nobuaki Minami, Shinichi Umezawa, Akira Kanamori, Hiroshi Takeda, Shogo Ito, Taisuke Kikuchi, Hikaru Amemiya, Mizuki Kaneshiro, Atsuko Mokubo, Tetsuo Takuma, Hideo Machimura, Keiji Tanaka, Taro Asakura, Akira Kubota, Sachio Aoyanagi, Kazuhiko Hoshino, Masashi Ishikawa, Yoko Matsuzawa, Mitsuo Obana, Nobuo Sasai, Hideaki Kaneshige, Fuyuki Minagawa, Tatsuya Saito, Kazuaki Shinoda, Masaaki Miyakawa, Yasushi Tanaka, Yasuo Terauchi, Ikuro Matsuba
BACKGROUND: Ipragliflozin is a selective sodium glucose co-transporter 2 inhibitor. The ASSIGN-K study is investigating the efficacy and safety of ipragliflozin for type 2 diabetes mellitus (T2DM) in the real-world clinical setting. METHODS: Japanese T2DM patients with inadequate glycemic control despite diet and exercise with/without pharmacotherapy were enrolled in an investigator-driven, multicenter, prospective, observational study examining the efficacy and safety of ipragliflozin treatment (50 mg/day for 52 weeks)...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28802293/overall-nutrient-and-total-fat-intake-among-japanese-people-the-interlipid-study-japan
#15
Tatsuya Koyama, Katsushi Yoshita, Nagako Okuda, Shigeyuki Saitoh, Kiyomi Sakata, Akira Okayama, Hideaki Nakagawa, Naoko Miyagawa, Katsuyuki Miura, Queenie Chan, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima
BACKGROUND AND OBJECTIVES: Total fat intake is linked to the intake of other nutrients. Little data are available on the extent to which total fat affects diet quality in Japanese people. We investigated the relationship between total fat intake and other nutrient intake using INTERLIPID/ INTERMAP data on Japanese people living in Japan. METHODS AND STUDY DESIGN: The participants included 371 men and 401 women with a healthy body mass index and between the ages of 40 and 59 from 4 population samples in Japan...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28789727/food-based-diet-quality-score-in-relation-to-depressive-symptoms-in-young-and-middle-aged-japanese-women
#16
Hiroka Sakai, Kentaro Murakami, Satomi Kobayashi, Hitomi Suga, Satoshi Sasaki
Only a few studies have focused on the association between overall diet, rather than intakes of individual nutrients or foods, and depressive symptoms in Japanese. This cross-sectional study examined associations between a diet quality score and depressive symptoms in 3963 young (age 18 years) and 3833 middle-aged (mean age 47·9 (sd 4·2) years) Japanese women. Dietary information was collected using a diet history questionnaire. A previously developed diet quality score was computed mainly based on the Japanese Food Guide Spinning Top...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28781315/unexpected-acute-necrotizing-ulcerative-gingivitis-in-a-well-controlled-hiv-infected-case
#17
Hirofumi Kato, Akifumi Imamura
We herein report the case of a 41-year-old Japanese man with well-controlled HIV who presented with diagnostically difficult acute necrotizing ulcerative gingivitis (ANUG). After diet-induced weight loss, he developed oral pain and disturbance of mouth opening, and was admitted to our hospital. Based on preconceptions of HIV-associated diseases, fluconazole was initiated for candidiasis. However, no improvement was seen and ANUG was finally diagnosed. This case suggests that physicians should consider ANUG in HIV-infected individuals when several risk factors are present, even if CD4+ T-lymphocyte counts have remained stable owing to long-term anti-retroviral therapy...
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28757530/perceived-6-n-propylthiouracil-prop-bitterness-is-associated-with-dietary-sodium-intake-in-female-japanese-college-students
#18
Hiroko Inoue, Toshiko Kuwano, Kimiko Yamakawa-Kobayashi, Toshiharu Waguri, Teruyo Nakano, Yuichi Suzuki
Despite the negative health consequences of a high sodium consumption, humans consume well above the recommended levels. This study examines whether or not the dietary intake of sodium was affected by individual variation of the perceived bitterness of 6-n-propylthiouracil (PROP), and examines the relationship between the perceived bitterness of PROP and the preferred NaCl concentration of broth. Female students (20-22 y old) were recruited from the university community. Genotypes of A49P and I296V polymorphism of the TAS2R38 bitter taste receptor were determined for each subject...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28755191/tyrosinemia-type-i-in-japan-a-report-of-five-cases
#19
Kimitoshi Nakamura, Michinori Ito, Yosuke Shigematsu, Fumio Endo
Tyrosinemia type I in Japan was reported for the first time in 1957 by Sakai et al. (Jikei Med J 2:1-10, 1957) and Kitagawa et al. (Proc Jpn Acad Ser B 88:192-200, 1957). Five cases of patients with tyrosinemia type I were reported to be definitively diagnosed in Japan. The first case was reported by Sakai et al. and Kitagawa et al. To the best of our knowledge, this was the first definite report in the world. The second and third cases were those of a brother and a sister who underwent liver transplantation and who were the children of a Japanese-descent migrant worker; the fourth case was that of a girl who underwent liver transplantation after 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) treatment, which was reported by Hata et al...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28751928/a-decrease-of-brain-microrna-122-level-is-an-early-marker-of-cerebrovascular-disease-in-the-stroke-prone-spontaneously-hypertensive-rat
#20
Rosita Stanzione, Franca Bianchi, Maria Cotugno, Simona Marchitti, Maurizio Forte, Carla Busceti, Larisa Ryskalin, Francesco Fornai, Massimo Volpe, Speranza Rubattu
Based on preliminary evidence that highlights microRNA-122 as a contributing factor to stroke pathogenesis, we aimed at assessing its expression level, along with the presence of early signs of cerebrovascular disease, in the brain of stroke-prone spontaneously hypertensive rat (SHRSP), a suitable model of human disease that accelerates stroke occurrence under a high sodium/low potassium (Japanese-style) diet (JD). After one month of JD, before stroke occurrence, brain microRNA-122 level was significantly decreased in SHRSP as compared to the stroke-resistant SHR (SHRSR)...
2017: Oxidative Medicine and Cellular Longevity
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