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uveitis children

Madan Upadhyay, Ranju Kharel Sitaula, Bharat Shrestha, Bhaiya Khanal, Bishnu Psd Upadhyay, Jeevan B Sherchand, Prakash Ghimire
PURPOSE: This review aims to provide a detailed update in Seasonal hypercute panuveitis (SHAPU) which is a blinding disease of unknown etiology reported only from Nepal, occurring every odd year since 1975 predominantly in children. METHODS: Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1975 to late 2017). Search items included SHAPU, seasonal endophthalmitis, hypopyon uveitis, caterpillar induced uveitis alone or in combination with white moth, panuveitis, and review...
March 15, 2018: Ocular Immunology and Inflammation
Nicholas P Jones, Archana Pradeep, Binu John
PURPOSE: To identify the causes of severe visual loss in a UK uveitis clinic, to suggest means of reducing incidence, and to propose improvement in data collection of vision impairment. PATIENTS AND METHODS: Retrospective case series. RESULTS: Over 128 months, 76 (3.5-4% of patients referred) were certified as vision-impaired or severely vision-impaired. The mean age at registration was 48.4 years, 76% were of working age, and 7% were children...
March 15, 2018: Ocular Immunology and Inflammation
Giorgio Ottaviano, Silvia Salvatore, Alessandro Salvatoni, Stefano Martelossi, Alessandro Ventura, Samuele Naviglio
Background and aims: Ocular extraintestinal manifestations (O-EIMs) are known complications of Crohn's disease (CD), ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBD-U). However, data on their prevalence in children are scarce and there are no clear recommendations on which follow-up should be offered. We aimed to review available data on O-EIMs in children. Methods: In January 2018, we performed a systematic review of published English literature using PubMed and EMBASE databases using disease-specific queries...
March 6, 2018: Journal of Crohn's & Colitis
Anne-Mieke J W Haasnoot, Marco W Schilham, Sylvia Kamphuis, Petra C E Hissink Muller, Arnd Heiligenhaus, Dirk Foell, Kirsten Minden, Roel A Ophoff, Timothy R D J Radstake, Anneke I Den Hollander, Tjitske H C M Reinards, Sanne Hiddingh, Nicoline E Schalij-Delfos, Esther P A H Hoppenreijs, Marion A J van Rossum, Carine Wouters, Rotraud K Saurenmann, J Merlijn van den Berg, Nico M Wulffraat, Rebecca Ten Cate, Joke H de Boer, Sara L Pulit, Jonas J W Kuiper
OBJECTIVES: Uveitis is a visually-debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. To identify genetic susceptibility loci for uveitis in JIA, we conducted a genome-wide association study totalling 522 JIA cases. METHODS: We genotyped two cohorts of JIA patients with ophthalmological follow-up and then imputed the data using a genome-wide imputation reference panel, and an HLA-specific reference panel used for imputing amino acids and HLA types in the major histocompatibility complex (MHC)...
March 7, 2018: Arthritis & Rheumatology
Iris Deitch, Radgonde Amer, Oren Tomkins-Netzer, Zohar Habot-Wilner, Ronit Friling, Ron Neumann, Michal Kramer
PURPOSE: This study aimed to report the clinical outcome of children with uveitis treated with anti-tumor necrosis factor alpha (TNF-α) agents. METHODS: This included a retrospective cohort study. Children with uveitis treated with infliximab or adalimumab in 2008-2014 at five dedicated uveitis clinics were identified by database search. Their medical records were reviewed for demographic data, clinical presentation, ocular complications, and visual outcome. Systemic side effects and the steroid-sparing effect of treatment were documented...
February 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Justus G Garweg
BACKGROUND: Pediatric uveitis is associated with a high incidence of severe and frequently permanent visual loss. This article summarizes the current understanding of the disease and the therapeutic options that are available to improve treatment outcomes. METHODS: A Medline search spanning the last 10 years was undertaken using the key terms "pediatric uveitis" or "childhood uveitis" and "macular edema". Articles which appertained to case reports or small case series were excluded from consideration, whereas those in which the opinions of experts were expressed, as well as reviews, were not...
February 16, 2018: Klinische Monatsblätter Für Augenheilkunde
Fatma Yazılıtaş, Özlem Aydoğ, Sare Gülfem Özlü, Evrim Kargın Çakıcı, Tülin Güngör, Fehime Kara Eroğlu, Gökçe Gür, Mehmet Bülbül
Familial Mediterranean fever (FMF), the most common hereditary autoinflammatory disorder is characterized by recurrent episodes of fever, serositis, arthritis. The major long-term result is amyloidosis. Colchicine remains the principle of the treatment; it not only prevents the acute attacks but also prevents the long-term complications such as amyloidosis; 5-10% of the patients are unresponsive to treatment. Recently new therapeutic options as anti-interleukin 1 agents are successfully used for the patients who do not respond to colchicine treatment...
February 15, 2018: Rheumatology International
David M Clive, Vijay K Vanguri
The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a multisystemic autoimmune disorder that may occur in response to various environmental triggers, including drugs and microbial pathogens. Evidence exists of HLA antigen-related genetic predisposition to developing TINU. The resulting inflammation affects chiefly the ocular uvea and renal tubules, although other organs may be involved. TINU is uncommon; only about 200 cases are on record since its original description 40 years ago, although it is possible that new ones are no longer being reported...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Natasha Gautam Seth, Sonam Yangzes, Faisal Thattaruthody, Ramandeep Singh, Reema Bansal, Srishti Raj, Sushmita Kaushik, Vishali Gupta, Surinder Singh Pandav, Jagat Ram, Amod Gupta
PURPOSE: To study outcome of secondary glaucoma in pediatric uveitis patients. METHODS: Retrospective analysis of records of uveitis patients ≤16 years. RESULTS: Of 182 pediatric uveitis patients, secondary glaucoma was seen in 48 patients (75 eyes, 26.23%) with female preponderance (F:M-29:19) . JIA was the most common etiology (35.71%). BCVA of ≥20/40 was seen in 22 eyes at presentation and in 38 eyes at final follow up (p<0.001)...
February 2, 2018: Ocular Immunology and Inflammation
Dhanashree Ratra, Atanu Barh, Manideepa Banerjee, Vineet Ratra, Jyotirmay Biswas
PURPOSE: To assess safety and efficacy of intravitreal dexamethasone (DEX) implant in refractory uveitic macular edema (ME). METHODS: We retrospectively analyzed medical records of patients with nonresponsive ME secondary to chronic, noninfectious intermediate or posterior uveitis, treated with intravitreal DEX implants. RESULTS: A total of 42 eyes of 34 patients (aged 6-67 years) received 56 implants. Mean follow-up was 19.2 ± 2.2 months after DEX implant...
February 2, 2018: Ocular Immunology and Inflammation
Ligia Sancho, Michal Kramer, Adi Koriat, Maya Eiger-Moscovich, Yael Sharon, Radgonde Amer
PURPOSE: To study the prevalence and time of onset of ocular complications in intermediate uveitis (IU) and to assess their effects on visual outcome in short-term and long-term follow-up. METHODS: A retrospective cohort study of patients with IU who had a minimal follow-up of one year. RESULTS: 96 patients (174 eyes, 70% females) were included with a mean age at presentation of 30 years. Children constituted 38% of all patients. Mean follow- up was 64...
January 25, 2018: Ocular Immunology and Inflammation
Parthopratim Dutta Majumder, Sowkath Ali, Amala George, Sudha Ganesh, Jyotirmay Biswas
PURPOSE: To describe the clinical pattern of scleritis in patients ≤16 years of age at a tertiary care eye hospital in India. METHODS: The medical records of 24 eyes of 20 children with scleritis were included in this retrospective study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), detailed laboratory investigations and treatment. RESULTS: Mean age at presentation was 12.2 ± 2.5 years. Scleritis was unilateral in 80% patients and an equal gender distribution was observed...
January 25, 2018: Ocular Immunology and Inflammation
Alf Nyström, Nawaf Almarzouki, Gunilla Magnusson, Madeleine Zetterberg
PURPOSE: To report outcome in a paediatric cohort with cataract extraction and implantation of bag-in-the-lens intraocular lens (BIL-IOL). METHODS: Children younger than 16 years of age subjected to phacoemulsification with primary implantation of BIL-IOL during 2009 through 2013 were analysed retrospectively. Exclusion criteria were uveitis or ≤6 months of follow-up. RESULTS: In total, 109 eyes of 84 children were included; 40 unilateral and 44 bilateral cataracts...
January 19, 2018: Acta Ophthalmologica
Edita Puodžiuvienė, Giedrė Jokūbauskienė, Monika Vieversytė, Kirwan Asselineau
BACKGROUND: Pediatric trauma can lead to serious visual impairment as a result of the trauma itself or secondary to amblyopia. Precise data on epidemiological characteristics and visual outcomes of pediatric ocular injuries are valuable for the prevention of monocular blindness. METHODS: A total of 268 cases of pediatric ocular trauma admitted to the Department of Ophthalmology of the Lithuanian University of Health Sciences Hospital from January 2008 to December 2013 were retrospectively reviewed...
January 18, 2018: BMC Ophthalmology
Mariantonia Ferrara, Laura Eggenschwiler, Andrew Stephenson, Alyssa Montieth, Nakhoul Nakhoul, Rafael Araùjo-Miranda, C Stephen Foster
PURPOSE: To describe the distribution, clinical findings, visual outcomes, treatment, and complications of children with uveitis at a tertiary referral ophthalmic center. METHODS: Retrospective cohort study. We reviewed the medical records of all patients ≤16 years with uveitis referred to Massachusetts Eye Research and Surgery Institution from March 2005 to July 2016. RESULTS: Of 286 included children, 62.24% were female. Mean age of onset was 8...
January 15, 2018: Ocular Immunology and Inflammation
Olajumoke A Shona, Farrah Islam, Anthony G Robson, Andrew R Webster, Anthony T Moore, Michel Michaelides
PURPOSE: To review and describe in detail the demographics, functional and anatomical characteristics, and clinical course of pigmented paravenous chorioretinal atrophy in a large cohort of adults and children. METHODS: This is a retrospective case series of consecutive patients diagnosed with pigmented paravenous chorioretinal atrophy at a single U.K. referral center from 1974 to 2016. Clinical records, retinal imaging (color fundus photography, fundus autofluorescence, and optical coherence tomography), and electrophysiological assessments were reviewed...
January 3, 2018: Retina
Emine Sen, Melike Balikoglu-Yilmaz, Pinar Ozdal
OBJECTIVE: To compare the corneal biomechanics, intraocular pressure (IOP), and central corneal thickness (CCT) of 37 patients with pediatric noninfectious uveitis with 36 healthy children. METHODS: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated and corneal-compensated IOP (IOPg and IOPcc, respectively), and CCT were measured. RESULTS: The mean CRF was significantly lower in the pediatric uveitic eyes than controls (9...
December 27, 2017: Eye & Contact Lens
Sibylle Winterhalter, Uwe Diedrich Behrens, Daniel Salchow, Antonia M Joussen, Uwe Pleyer
BACKGROUND: To evaluate the efficacy and safety of dexamethasone (DEX) implants in paediatric patients with noninfectious intermediate or posterior uveitis. METHODS: Prospective single center exploratory case series. Children and adolescents, 6 to 17 years old, with a vitreous haze score of ≥1.5+ or cystoid macular edema (CME) of >300 μm were enrolled. Vitreous haze score at month 2 was chosen as primary endpoint. Best corrected visual acuity (BCVA), central retinal thickness (CRT) and concomitant medication at month 6 were defined as secondary endpoints...
December 16, 2017: BMC Ophthalmology
Lara Borrego-Sanz, Lydia Abásolo, Consuelo López-Abad, Benjamín Fernández-Gutiérrez, Julián García-Feijoo, David Diaz-Valle, Esperanza Pato, Luis Rodriguez-Rodriguez
PURPOSE: To report the incidence rate (IR) of remission in pediatric noninfectious intermediate uveitis (IU). METHODS: Longitudinal retrospective cohort study, including 19 patients (32 eyes) between 1985 and 2014, followed-up until loss or January 2016. Remission was defined following the Standardization of Uveitis Nomenclature workshop criteria, prolonged remission as a remission spanning 12 months and until the end of follow-up, and relapse as recurrence of inflammatory activity in an eye in remission...
December 14, 2017: Ophthalmologica. Journal International D'ophtalmologie
Beata Zelazowska-Rutkowska, Malgorzata Mrugacz, Bogdan Cylwik
BACKGROUND: Uveitis is the inflammation of the uvea that often occurs in children. There are many causes of disease, but some of them do not have any reasons and are then called idiopathic uveitis. Cytokines play an important role in the regulation of the immune response. Determination of cytokine profiles could contribute to the explanation of the etiology of uveitis and could serve to evaluate the inflammation intensity as well as be helpful in the early diagnosis this disease. The purpose of this study was to determine the serum level of selected inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF-α) and to compare their diagnostic power as a markers of idiopathic anterior uveitis in children...
November 1, 2017: Clinical Laboratory
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