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uveitis children

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https://www.readbyqxmd.com/read/27848185/pediatric-intestinal-beh%C3%A3-et-disease-complicated-by-myeloid-malignancies
#1
Kiichiro Kanamitsu, Akira Shimada, Ritsuo Nishiuchi, Tomonari Shigemura, Yozo Nakazawa, Kenichi Koike, Yuichi Kodama, Yuichi Shinkoda, Yoshifumi Kawano, Kozo Yasui, Koji Sasaki, Ryosuke Kajiwara, Hirokazu Tsukahara, Atsushi Manabe
Behçet disease (BD) is rarely seen in children. Its clinical manifestations are believed to differ between pediatric and adult patients. The characteristics of BD complicated by myelodysplastic syndrome (MDS) are well established for adult patients; however, because only a few cases of pediatric-onset BD complicated by MDS have been reported, its clinical characteristics remain unknown. We here retrospectively review pediatric-onset BD complicated by myeloid malignancies in Japan, having identified five such patients...
November 15, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27843575/effectiveness-and-safety-of-tnf-inhibitors-in-adults-with-juvenile-idiopathic-arthritis
#2
Lianne Kearsley-Fleet, Flora McErlane, Helen E Foster, Mark Lunt, Kath D Watson, Deborah P M Symmons, Kimme L Hyrich
INTRODUCTION: Many children with juvenile idiopathic arthritis (JIA) continue to have active disease into adulthood. Adults with JIA are a heterogeneous group, and the effects of tumour necrosis factor inhibitor (TNFi) therapies are not well described. This analysis aims to describe treatment outcomes among patients with JIA starting TNFi for the first time in adulthood. METHODS: Patients with arthritis onset <16 years starting their first TNFi therapy were identified from the British Society of Rheumatology Biologics Register...
2016: RMD Open
https://www.readbyqxmd.com/read/27781126/fuchs-heterochromic-iridocyclitis-in-an-italian-tertiary-referral-centre-epidemiology-clinical-features-and-prognosis
#3
Massimo Accorinti, Giovanni Spinucci, Maria Pia Pirraglia, Simone Bruschi, Francesca Romana Pesci, Ludovico Iannetti
Purpose. To study epidemiology, clinical findings and visual prognosis of patients with Fuchs' Heterochromic Iridocyclitis (FHI). Methods. A retrospective analysis was performed on 158 patients with FHI. Thirty-five patients were observed only once; the remaining 123 had a mean follow-up of 30.7 months (50 of them had a mean follow-up of 63.5 months) and in those we assessed complications, medical and surgical treatment, and long-term visual prognosis. Results. Average age at uveitis diagnosis was 27.2 years and 18...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27767364/pattern-of-pediatric-uveitis-at-a-tertiary-referral-institute-in-north-india
#4
Natasha Gautam, Ramandeep Singh, Aniruddha Agarwal, Sonam Yangzes, Mohit Dogra, Ashok Sharma, Reema Bansal, Vishali Gupta, Mangat R Dogra, Amod Gupta
PURPOSE: To report the pattern of pediatric uveitis in a tertiary care referral center in North India. METHODS: In a retrospective study, records of pediatric uveitis cases presenting at our center between 1996 and 2015 were reviewed for demographic data, anatomic distribution, and diagnosis. RESULTS: Out of 9600 patients with uveitis, 369 children (3.84%; age ≤16 years; males: 54.20%) were included in the study. Anterior uveitis was the commonest presentation (n = 158; 42...
October 21, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27765666/safety-efficacy-and-pharmacokinetics-of-a-single-tablet-regimen-containing-elvitegravir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-treatment-naive-hiv-infected-adolescents-a-single-arm-open-label-trial
#5
Aditya H Gaur, Hilda Kizito, Wasana Prasitsueubsai, Natella Rakhmanina, Mohammed Rassool, Rana Chakraborty, Jagmohan Batra, Pope Kosalaraksa, Wicharn Luesomboon, Danielle Porter, Yongwu Shao, Michael Myers, Lillian Ting, Devi SenGupta, Erin Quirk, Martin S Rhee
BACKGROUND: The prodrug tenofovir alafenamide is associated with improved renal and bone safety compared with tenofovir disoproxil fumarate. We aimed to assess safety, pharmacokinetics, and efficacy of this single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-infected, treatment-naive adolescents. METHODS: We did a 48 week, single-arm, open-label trial in treatment-naive adolescents with HIV from ten hospital clinics in South Africa, Thailand, Uganda, and the USA...
December 2016: Lancet HIV
https://www.readbyqxmd.com/read/27681455/management-of-pseudophakic-myopic-anisometropic-amblyopia-with-piggyback-visian-%C3%A2-implantable-collamer-lens
#6
Sherif A Eissa
PURPOSE: To assess the outcomes of sulcus implantation of the Visian(®) implantable collamer lens (ICL) to correct pseudophakic myopic anisometropic amblyopia with myopic shift and/or primary refractive overcorrection. METHODS: Prospective case series enrolled 14 pseudophakic eyes of 14 patients, 5-9 years old, with history of cataract surgery and primary in the bag-intraocular lenses (IOL) implantation, followed by myopic shift and/or refractive overcorrection and anisometropic amblyopia of variable degrees...
September 29, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27608193/prevalence-of-noninfectious-uveitis-in-the-united-states-a-claims-based-analysis
#7
Jennifer E Thorne, Eric Suhler, Martha Skup, Samir Tari, Dendy Macaulay, Jingdong Chao, Arijit Ganguli
Importance: Noninfectious uveitis (NIU) is a collection of intraocular inflammatory disorders that may be associated with significant visual impairment. To our knowledge, few studies have investigated NIU prevalence overall or stratified by inflammation location, severity, presence of systemic conditions, age, or sex. Objective: To estimate NIU prevalence using a large, retrospective, administrative claims database. Design, Setting, and Participants: This analysis used the OptumHealth Reporting and Insights database to estimate 2012 NIU prevalence...
September 8, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27601874/a-10-year-review-of-pediatric-uveitis-at-a-hispanic-dominated-tertiary-pediatric-ophthalmic-clinic
#8
Kruti P Dajee, Jennifer Landau Rossen, Monica L Bratton, Jess T Whitson, Yu-Guang He
PURPOSE: The aim of this study was to evaluate the characteristics and outcomes of pediatric uveitis cases at a large tertiary referral center in Dallas, TX, USA. MATERIALS AND METHODS: The authors performed a retrospective chart review between 2001 and 2011 to identify children with uveitis. RESULTS: A total of 46 children (68 eyes) with uveitis were identified. Sixty-seven percent were Hispanic, and the mean age was 9.2 years. The majority of cases were idiopathic (74%)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27600159/autoimmune-sensorineural-hearing-loss-as-presenting-manifestation-of-paediatric-beh%C3%A3-et-disease-responding-to-adalimumab-a-case-report
#9
Manuela Marsili, Valentina Marzetti, Marta Lucantoni, Giuseppe Lapergola, Marco Gattorno, Francesco Chiarelli, Luciana Breda
BACKGROUND: Autoimmune sensorineural hearing loss, also known as autoimmune inner ear disease (AIED) is a rare clinical entity characterized by progressive and bilateral sensorineural hearing loss often accompanied by vestibular symptoms. Diagnosis is essential as a consistent number of patients show a positive response to steroids alone or in association with other immunosuppressive drugs. AIED is defined as primary when the disease is limited to the ear, whereas in up to a third of cases it is associated to other systemic autoimmune diseases such as Behçet disease (BD)...
2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27599095/cataract-surgery-with-primary-lens-implantation-in-children-with-chronic-uveitis
#10
Damien Guindolet, Pascal Dureau, Céline Terrada, Catherine Edelson, Amandine Barjol, Georges Caputo, Phuc LeHoang, Bahram Bodaghi
PURPOSE: To evaluate the evolution of chronic uveitis in children undergoing cataract surgery with primary intraocular lens (IOL) implantation. METHODS: Twelve children with chronic uveitis underwent cataract surgery with primary posterior chamber intraocular lens (IOL) implantation. RESULTS: Fourteen eyes were implanted with a foldable hydrophobic acrylic IOL. The mean follow-up was 35.39 months (8.72-69.57). The mean BCDVA before surgery and at the end of follow-up was 1...
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27599045/pseudotumour-cerebri-syndrome-in-two-children-on-systemic-steroid-therapy-for-uveitis
#11
David Curragh, Eibhlin McLoone
No abstract text is available yet for this article.
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27598822/phacoemulsification-with-intraocular-lens-implantation-in-pediatric-uveitis-a-retrospective-study
#12
Sudha K Ganesh, Saurabh Mistry
PURPOSE: To analyze the outcome of phacoemulsification with primary posterior chamber intraocular lens (IOL) implantation without primary posterior capsulorhexis in older children with uveitis. METHODS: Retrospective study of children with uveitis who underwent phacoemulsification with IOL implantation between January 2006 and May 2014. RESULTS: Twenty-one eyes of 16 children were included. Mean age at cataract surgery was 10.9 years. Juvenile idiopathic arthritis was associated in 37...
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27555706/demographic-and-clinical-features-of-pediatric-uveitis-at-a-tertiary-referral-center-in-iran
#13
Mansour Rahimi, Marjan Oustad, Afsaneh Ashrafi
PURPOSE: To determine the clinical features and distribution of uveitis in the pediatric age group at a referral eye care center in Shiraz, South Iran. MATERIALS AND METHODS: All new cases of uveitis in patients 18-year-old or younger referred from January 2007 to December 2013 were enrolled in this study. The patient underwent a complete history of systemic and ocular diseases, comprehensive ophthalmic examination. Patients were classified according to the International Uveitis Study Group definitions...
July 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27471956/uveitis-in-children-and-adolescents
#14
Emmett T Cunningham, Justine R Smith, Ilknur Tugal-Tutkun, Aniki Rothova, Manfred Zierhut
No abstract text is available yet for this article.
August 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27470424/role-of-chronic-inflammation-in-myopia-progression-clinical-evidence-and-experimental-validation
#15
Hui-Ju Lin, Chang-Ching Wei, Ching-Yao Chang, Ter-Hsin Chen, Yu-An Hsu, Yi-Ching Hsieh, Hsuan-Ju Chen, Lei Wan
Prevention and treatment of myopia is an important public problem worldwide. We found a higher incidence of myopia among patients with inflammatory diseases such as type 1 diabetes mellitus (7.9%), uveitis (3.7%), or systemic lupus erythematosus (3.5%) compared to those without inflammatory diseases (p<0.001) using data from children (<18years old) in the National Health Insurance Research database. We then examined the inhibition of myopia by atropine in Syrian hamsters with monocular form deprivation (MFD), an experimental myopia model...
August 2016: EBioMedicine
https://www.readbyqxmd.com/read/27385618/methotrexate-treatment-may-prevent-uveitis-onset-in-patients-with-juvenile-idiopathic-arthritis-experiences-and-subgroup-analysis-in-a-cohort-with-frequent-methotrexate-use
#16
Mikhail M Kostik, Ekaterina V Gaidar, Alla Y Hynnes, Margarita F Dubko, Vera V Masalova, Ludmil S Snegireva, Irina A Chikova, Eugenia A Isupova, Tatiana N Nikitina, Elena D Serogodskaya, Olga V Kalashnikova, Angelo Ravelli, Vyacheslav G Chasnyk
OBJECTIVES: To re-evaluate the ability of methotrexate (MTX) to prevent the onset of uveitis in Russian children with juvenile idiopathic arthritis (JIA). METHODS: The clinical charts for all consecutive patients who received a stable management for at least 2 years with or without MTX were reviewed. Patients who were given systemic medications other than MTX (except NSAID) and patients with systemic arthritis, rheumatoid factor-positive arthritis, or enthesitis-related arthritis were excluded...
July 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27369649/association-of-traf1-c5-with-risk-of-uveitis-in-juvenile-idiopathic-arthritis
#17
Yves-Marie Pers, Pierre Le Blay, Catherine Ludwig, Cécile Rittore, Gautier Tejedor, Randy Foliwe, Michel Rodiere, Christian Jorgensen, Isabelle Touitou
OBJECTIVES: Numerous single nucleotide polymorphisms (SNPs) have been associated with JIA, but few of these studies were replicated. We conducted a candidate-gene approach study to assess if some SNPs could be related to clinical subtypes or other clinical features of the juvenile idiopathic arthritis (JIA) such as the risk of uveitis, ANA positivity and the age at onset. METHODS: SNPs in six genes were analysed: PTPN22, STAT4, TRAF1-C5, TGFbeta, TNFAIP3, and C12orf30...
June 28, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27335142/clinical-features-of-uveitis-in-children-and-adolescents-at-a-tertiary-referral-centre-in-tokyo
#18
Hiroshi Keino, Takayo Watanabe, Wakako Taki, Makiko Nakayama, Tomoko Nakamura, Kunimasa Yan, Annabelle A Okada
OBJECTIVES: To analyse clinical features, systemic associations, treatment and visual outcomes of uveitis in children and adolescents at a tertiary centre in Tokyo. METHODS: Clinical records of 64 patients under the age of 20 years who presented between 2001 and 2013 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo were reviewed retrospectively. RESULTS: Of the 64 patients, there was a predominance of girls (70%) and bilateral disease (81%)...
June 22, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27328333/uveitis-in-children
#19
Sheila T Angeles-Han, Consuelo Egla Rabinovich
PURPOSE OF REVIEW: The review provides updates on novel risk markers for the development of pediatric inflammatory uveitis and a severe disease course, on treatment of refractory disease, and on the measurement of visual outcomes. RECENT FINDINGS: There are several new genetic markers, biomarkers, and clinical factors that may influence a child's uveitis disease course. It is important to identify children at risk for poor visual outcomes and who are refractory to traditional therapy...
September 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27256096/clinical-course-and-therapeutic-approach-to-varicella-zoster-virus-infection-in-children-with-rheumatic-autoimmune-diseases-under-immunosuppression
#20
Raphael Leuvenink, Florence Aeschlimann, Walter Baer, Gerald Berthet, Elvira Cannizzaro, Michael Hofer, Daniela Kaiser, Silke Schroeder, Ulrich Heininger, Andreas Woerner
BACKGROUND: To analyze the clinical presentation and complications of varicella zoster virus (VZV) infection in children with rheumatic diseases treated with immunosuppressive medication such as biological disease-modifying antirheumatic drugs (bDMARDs) and/or conventional disease-modifying antirheumatic drugs (cDMARDs), and to analyze the therapeutic approach to VZV infections with respect to the concomitant immunosuppressive treatment. METHODS: Retrospective multicenter study using the Swiss Pediatric Rheumatology registry...
2016: Pediatric Rheumatology Online Journal
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