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Hyperosmolar hyperglycemic state

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https://www.readbyqxmd.com/read/27924173/predictors-of-recurrent-hospital-admission-for-patients-presenting-with-diabetic-ketoacidosis-and-hyperglycemic-hyperosmolar-state
#1
Annabel L Bradford, Courtney Champagne Crider, Xizheng Xu, Syed Hasan Naqvi
BACKGROUND: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two serious, preventable complications of diabetes mellitus. Analysis of variables associated with recurrent DKA and HHS admission has the potential to improve patient outcomes by identifying possible areas for intervention. The aim of this study was to evaluate potential predictors of recurrent DKA or HHS admission. METHODS: This was a retrospective case-control study of 367 patients presenting during a 5-year period with DKA or HHS at a US tertiary academic medical center...
January 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27875539/secular-trends-in-admissions-and-mortality-rates-from-diabetes-mellitus-in-the-central-belt-of-ghana-a-31-year-review
#2
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Benjamin Eghan, Nana Kwame Ayisi-Boateng, Emmanuel Acheamfour-Akowuah
INTRODUCTION: Diabetes Mellitus is currently a leading cause of morbidity and mortality throughout the world, particularly in sub-Saharan Africa where a significant proportion of diabetes cases are now found. Longitudinal profiling of in-patient admissions and mortality trends from diabetes provide useful insights into the magnitude of the burden of diabetes, serve as a sentinel on the state of out-patient diabetes care and provide effective tools for planning, delivering and evaluating the health care needs relating to the disease in sub-Saharan Africa...
2016: PloS One
https://www.readbyqxmd.com/read/27863115/reversible-splenial-lesion-syndrome-with-a-hyperosmolar-hyperglycemic-state-and-neuroleptic-malignant-syndrome-caused-by-olanzapine
#3
Kenta Kaino, Ryo Kumagai, Shoko Furukawa, Momoko Isono, Aiko Muramatsu, Masanao Fujii, Yumiko Muta, Tomoyuki Asada, Kazuya Fujihara, Hiroaki Yagyu
A 27-year-old woman with panic disorder taking 20 mg olanzapine daily for 4 months was admitted to our hospital because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity, and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state (HHS) and neuroleptic malignant syndrome (NMS). Brain magnetic resonance imaging (MRI) showed transiently restricted diffusion in the splenium of the corpus callosum (SCC), with a high signal intensity on diffusion-weighted imaging...
November 18, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27851450/1815-opsoclonus-a-rare-and-interesting-neurologic-manifestation-of-hyperosmolar-hyperglycemic-state
#4
Shyam Shankar, Hatem Desoky, Ishan Malhotra, Mangalore Amith Shenoy, Anand Kumar Rai, Benhoor Shamian, Yizhak Kupfer
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27395337/inverse-relationship-between-ambient-temperature-and-admissions-for-diabetic-ketoacidosis-and-hyperglycemic-hyperosmolar-state-a-14-year-time-series-analysis
#5
Chin-Li Lu, Hsin-Hui Chang, Hua-Fen Chen, Li-Jung Elizabeth Ku, Ya-Hui Chang, Hsiu-Nien Shen, Chung-Yi Li
This study aimed to investigate the association of admissions for diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) with ambient temperature and season, respectively in patients with diabetes mellitus (DM), after excluding known co-morbidities that predispose onset of acute hyperglycemia events. This was a time series correlation analysis based on medical claims of 40,084 and 33,947 episodes of admission for DKA and HHS, respectively over a 14-year period in Taiwan. These episodes were not accompanied by co-morbidities known to trigger incidence of DKA and HHS...
September 2016: Environment International
https://www.readbyqxmd.com/read/27266068/-hyperglycemic-hyperosmolar-state
#6
Tetsuyuki Yasuda
No abstract text is available yet for this article.
April 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27055605/hamman-syndrome-pneumomediastinum-combined-with-hyperosmolar-hyperglycemic-state
#7
Ichiro Hirayama, Takahiro Hiruma, Yoshihiro Ueda, Kent Doi, Susumu Nakajima
No abstract text is available yet for this article.
March 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26968192/hyperglycemic-hyperosmolar-state-associated-with-invasive-rhino-orbital-aspergillosis-in-a-patient-with-end-stage-renal-disease
#8
Ju Hyun Seo, Jin Ah Kim, Bomi Choi, Kyo Hee Kim, Ha Neul Park, Hannah Seok, Tae Seo Sohn
No abstract text is available yet for this article.
March 10, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26741957/antipsychotic-therapy-induced-new-onset-diabetic-ketoacidosis
#9
Yashwant Agrawal, Kiran Lingala, Hemasri Tokala, Jagadeesh K Kalavakunta
Atypical antipsychotics are very widely used for various psychiatric ailments because of their less extrapyramidal side effects. Various reports of disturbances in glucose metabolism in the form of new onset diabetes mellitus, exacerbation of preexisting diabetes mellitus, diabetic ketoacidosis, hyperosmolar nonketotic coma, acute pancreatitis, and increased adiposity have been reported. We present a case of new onset diabetic ketoacidosis in a patient without a history of glucose intolerance who was being treated with olanzapine for bipolar disorder...
November 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/26554652/complications-of-hyperglycaemia-with-pi3k-akt-mtor-inhibitors-in-patients-with-advanced-solid-tumours-on-phase-i-clinical-trials
#10
E Geuna, D Roda, S Rafii, B Jimenez, M Capelan, K Rihawi, F Montemurro, T A Yap, S B Kaye, J S De Bono, L R Molife, U Banerji
BACKGROUND: PI3K-AKT-mTOR inhibitors (PAMi) are promising anticancer treatments. Hyperglycaemia is a mechanism-based toxicity of these agents and is becoming increasingly important with their use in larger numbers of patients. METHODS: Retrospective case-control study comparing incidence and severity of hyperglycaemia (all grades) between a case group of 387 patients treated on 18 phase I clinical trials with PAMi (78 patients with PI3Ki, 138 with mTORi, 144 with AKTi and 27 with PI3K/mTORi) and a control group of 109 patients treated on 10 phase I clinical trials with agents not directly targeting the PAM pathway...
December 1, 2015: British Journal of Cancer
https://www.readbyqxmd.com/read/26455633/predictors-and-treatment-outcome-of-hyperglycemic-emergencies-at-jimma-university-specialized-hospital-southwest-ethiopia
#11
Tigestu Alemu Desse, Tesfahun Chanie Eshetie, Esayas Kebede Gudina
BACKGROUND: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) commonly known as hyperglycemic emergencies are the two most common life-threatening acute metabolic complications of diabetes. The objective of this study is to assess predictors and treatment outcome of hyperglycemic emergencies (HEs) among diabetic patients admitted to Jimma University Specialized Hospital (JUSH). METHODS: It is a three year retrospective review of medical records of patients admitted with HEs at JUSH...
October 11, 2015: BMC Research Notes
https://www.readbyqxmd.com/read/26184523/an-uncommon-complication-of-hyperosmolar-hyperglycemic-state-bilateral-above-knee-amputations
#12
Alyssa Milano, Ara Tadevosyan, Regina Hart, Anthony Luizza, Mary Eberhardt
No abstract text is available yet for this article.
February 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26120945/perphenazine-associated-hyperosmolar-hyperglycemic-state
#13
Michelle Samson Maust, Russ S Muramatsu, Kathryn Egan, Iqbal Ahmed
No abstract text is available yet for this article.
August 2015: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26115971/subsequent-mortality-after-hyperglycemic-crisis-episode-in-the-non-elderly-a-national-population-based-cohort-study
#14
Yuan Kao, Chien-Chin Hsu, Shih-Feng Weng, Hung-Jung Lin, Jhi-Joung Wang, Shih-Bin Su, Chien-Cheng Huang, How-Ran Guo
Hyperglycemic crisis episodes (HCEs)-diabetic ketoacidosis and the hyperosmolar hyperglycemic state-are the most serious acute metabolic complications of diabetes. We aimed to investigate the subsequent mortality after HCE in the non-elderly diabetic which is still unclear. This retrospective national population-based cohort study reviewed, in Taiwan's National Health Insurance Research Database, data from 23,079 non-elder patients (≤65 years) with new-onset diabetes between 2000 and 2002: 7693 patients with HCE and 15,386 patients without HCE (1:2)...
January 2016: Endocrine
https://www.readbyqxmd.com/read/26075855/-hyperosmolar-hyperglycemic-state
#15
REVIEW
Jaroslav Rybka, Jerguš Mistrík
The hyperglycemic hyperosmolar state (HHS) is a serious acute complication of diabetes decompensation, especially in type 2 diabetes (T2DM), and with critical prognosis. Primary characteristics of HHS include extreme hyperglycemia, severe dehydration (with prerenal hyperazotaemia), plasma hyperosmolarity, frequent disorders of consciousness, absent or minimum ketoacidosis (with higher values, only found in combined forms). Both DKA and HHS have a common pathogenetic mechanism, but both states are opposite extreme deviations, and the boundaries between them are not entirely clear...
May 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/25951940/presentation-of-youth-with-type-2-diabetes-in-the-pediatric-diabetes-consortium
#16
Georgeanna J Klingensmith, Crystal G Connor, Katrina J Ruedy, Roy W Beck, Craig Kollman, Heidi Haro, Jamie R Wood, Joyce M Lee, Steven M Willi, Eda Cengiz, William V Tamborlane
OBJECTIVE: Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D. METHODS: The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric diabetes centers in the USA. Clinical and laboratory characteristics at the time of diagnosis were analyzed. RESULTS: In total 67% presented with symptoms of diabetes and confirming laboratory data, but 33% were identified by testing at risk children, 11% presented with diabetic ketoacidosis (DKA), and 2% with hyperglycemic hyperosmolar state (HHS)...
June 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/25949947/prolonged-hypernatremia-triggered-by-hyperglycemic-hyperosmolar-state-with-coma-a-case-report
#17
Darlene Vigil, Kavitha Ganta, Yijuan Sun, Richard I Dorin, Antonios H Tzamaloukas, Karen S Servilla
A man with past lithium use for more than 15 years, but off lithium for two years and not carrying the diagnosis of diabetes mellitus or nephrogenic diabetes insipidus (NDI), presented with coma and hyperglycemic hyperosmolar state (HHS). Following correction of HHS, he developed persistent hypernatremia accompanied by large volumes of urine with low osmolality and no response to desmopressin injections. Urine osmolality remained < 300 mOsm/kg after injection of vasopressin. Improvement in serum sodium concentration followed the intake of large volumes of water plus administration of amiloride and hydrochlorothiazide...
May 6, 2015: World Journal of Nephrology
https://www.readbyqxmd.com/read/25945127/serum-c-peptide-assay-of-patients-with-hyperglycemic-emergencies-at-the-lagos-state-university-teaching-hospital-lasuth-ikeja
#18
Akinyele Taofiq Akinlade, Anthonia Okeoghene Ogbera, Olufemi Adetola Fasanmade, Michael Adeyemi Olamoyegun
INTRODUCTION: HE are common acute complications of diabetes mellitus (DM) and include diabetic ketoacidosis (DKA), normo-osmolar hyperglycemic state (NHS) and hyperosmolar hyperglycemic state (HHS). They contribute a lot to the mortality and morbidity of DM. The clinical features include dehydration, hyperglycemia, altered mental status and ketosis. The basic mechanism of HE is a reduction in the net effective action of circulating insulin, resulting in hyperglycemia and ketonemia (in DKA) causing osmotic diuresis and electrolytes loss...
2014: International Archives of Medicine
https://www.readbyqxmd.com/read/25845181/-endocrine-causes-of-acute-confusional-state
#19
REVIEW
Christoph Henzen
No abstract text is available yet for this article.
January 28, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25431711/osmotic-demyelination-syndrome-as-the-initial-manifestation-of-a-hyperosmolar-hyperglycemic-state
#20
Karla Victoria Rodríguez-Velver, Analy J Soto-Garcia, María Azucena Zapata-Rivera, Juan Montes-Villarreal, Jesús Zacarías Villarreal-Pérez, René Rodríguez-Gutiérrez
Osmotic demyelination syndrome (ODS) is a life-threatening demyelinating syndrome. The association of ODS with hyperosmolar hyperglycemic state (HHS) has been seldom reported. The aim of this study was to present and discuss previous cases and the pathophysiological mechanisms involved in ODS secondary to HHS. A 47-year-old man arrived to the emergency room due to generalized tonic-clonic seizures and altered mental status. The patient was lethargic and had a Glasgow coma scale of 11/15, muscle strength was 4/5 in both lower extremities, and deep tendon reflexes were diminished...
2014: Case Reports in Neurological Medicine
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