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Aseptic meningitis

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https://www.readbyqxmd.com/read/28196635/childhood-meningitis-in-kuwait-in-the-era-of-post-pneumococcal-conjugate-vaccination-a-multicenter-study
#1
Hussain Sadeq, Entesar H Husain, Amna Alkoot, Suha Atyani, Abdullah Al-Fraij, Abdulrahman Al-Daithan, Talal AlSaleem, Anfal Taher, May Alenezi
This is a retrospective study to evaluate epidemiology and etiologies of childhood meningitis in Kuwait after the routine introduction of the pneumococcal conjugate vaccine. The data was collected from 196 patients in the period of 2010-2014. Aseptic meningitis accounted for 51% of the cases, bacterial meningitis accounted for 29% cases and partially treated meningitis were 20%. Organisms causing bacterial meningitis were: Streptococcus pneumoniae 40.4%, Neisseria meningitidis 17.6%, Haemophilus spp. 12.2%, other gram positive or negative 19...
February 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28195100/a-54-year-old-male-with-rapidly-progressive-neurologic-syndrome-clinicopathologic-correlation-of-a-rare-diagnosis
#2
Deepti Mutreja, Nikhil Moorchung, Salil Gupta, Rajeev Saxena, Rohini S Doshetty, Bhaskar Nandi
Diagnosis of systemic lupus erythematosus (SLE) as primary presentation with central nervous system involvement as a rapidly progressive neurologic syndrome is extremely rare. We present a rare case of a 54-year-old hypertensive male patient, who presented with a fulminant neurologic syndrome. He presented with cerebellar and meningeal signs, aseptic meningitis and had a rapid downhill course following admission. A postmortem revealed feature of systemic connective tissue fulfilling diagnostic criteria of SLE with lupus cerebritis...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28165786/trimethoprim-induced-aseptic-meningism
#3
Mary Ni Lochlainn, Hock C Gooi, Monday O Ogese, Dean J Naisbitt, Bahram Jafar-Mohammadi
No abstract text is available yet for this article.
February 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28164314/a-probable-case-of-west-nile-virus-transfusion-transmission
#4
Jamel A Groves, Hedyeh Shafi, Jim H Nomura, Ross M Herron, Devin Baez, Roger Y Dodd, Susan L Stramer
BACKGROUND: Transfusion-transmitted West Nile virus (WNV) infection is infrequent as a result of minipool (MP) and individual-donation (ID) nucleic acid testing (NAT) of blood donations. ID-NAT is triggered on the basis of local WNV activity identified by MP-NAT. STUDY DESIGN AND METHODS: A 78-year-old male patient who was treated for cardiac disease received 14 blood components from 30 donors in August 2016. He was discharged 7 days after aortic valve replacement and coronary bypass surgery, but was re-admitted on Day 12 with symptoms of viral infection, and eventually was diagnosed with aseptic meningitis...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28134085/digenic-mefv-tnfrsf1a-autoinflammatory-syndrome-with-relapsing-aseptic-neutrophilic-meningitis-and-chronic-myelitis
#5
Anne Murarasu, Catherine Dodé, Guillaume Sarrabay, Isabelle Klein, Thomas Papo, Karim Sacré
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January 26, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28121938/comparison-of-posterior-fossa-decompression-with-and-without-duraplasty-for-the-surgical-treatment-of-chiari-malformation-type-i-in-adult-patients-a-retrospective-analysis-of-103-patients
#6
Junchen Chen, Yongning Li, Tianyu Wang, Jun Gao, Jincheng Xu, Runlong Lai, Dianhui Tan
Chiari malformation type I (CM-I) is a congenital neurosurgical disease about the herniation of cerebellar tonsil through the foramen magnum. A variety of surgical techniques for CM-I have been used, and there is a controversy whether to use posterior fossa decompression with duraplasty (PFDD) or posterior fossa decompression without duraplasty (PFD) in CM-I patients. Here, we compared the clinical results and effectiveness of PFDD and PFD in adult patients with CM-I. The cases of 103 adult CM-I patients who underwent posterior fossa decompression with or without duraplasty from 2008 to 2014 were reviewed retrospectively...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28118536/csf-cytokines-correlate-with-aseptic-meningitis-and-blood-brain-barrier-function-in-neonatal-onset-multisystem-inflammatory-disease-nomid
#7
Jackeline Rodriguez-Smith, Yen-Chih Lin, Wanxia Li Tsai, Hanna Kim, Gina Montealegre-Sanchez, Dawn Chapelle, Yan Huang, Cailin H Sibley, Massimo Gadina, Robert Wesley, Bibiana Bielekova, Raphaela Goldbach-Mansky
OBJECTIVE: To evaluate proinflammatory cytokines and leukocyte subpopulations in cerebrospinal spinal fluid (CSF) and blood of NOMID patients post-treatment; and to compare inflammatory cytokines in CSF and blood in 6 patients treated with two IL-1 blockers, anakinra and canakinumab. METHODS: We immunophenotyped CSF on 17 anakinra-treated pediatric NOMID patients during routine follow-up visits between December 2011 and October 2013 and analyzed CSF cytokine levels in baseline and 3-5 years follow-up samples compared to healthy controls...
January 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28071799/seroepidemiological-and-phylogenetic-characterisation-of-neurotropic-enteroviruses-in-ireland-2005-2014
#8
Jorge Abboud Guerra, Allison Waters, Alison Kelly, Ursula Morley, Paul O'Reilly, Edwin O'Kelly, Jonathan Dean, Robert Cunney, Piaras O'Lorcain, Suzanne Cotter, Jeff Connell, Joanne O'Gorman, William W Hall, Michael Carr, Cillian F De Gascun
Enteroviruses (EVs) are associated with a broad spectrum of clinical presentation, including aseptic meningitis (AM), encephalitis, hand, foot and mouth disease, acute flaccid paralysis and acute flaccid myelitis. Epidemics occur sporadically and are associated with increased cases of AM in children. The present study describes the seroepidemiological analysis of circulating EVs in Ireland from 2005-2014 and phylogenetic characterisation of echovirus 30 (E-30), enterovirus A71 (EV-A71) and enterovirus D68 (EV-D68)...
January 10, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28056277/-direct-medical-costs-and-influencing-factors-in-severe-hand-foot-and-mouth-disease-in-children-aged-between-six-months-and-five-years-old
#9
Y M Zheng, J Yang, Q H Liao
Objective: To estimate the direct medical cost of severe hand, foot and mouth disease (HFMD) in patients aged less than five years. Methods: A stratified sampling method was used to collect data on severe HFMD cases reported in the National HFMD surveillance database between Jan 1, 2012, and Dec 31, 2013. The sampling was referenced with the national aetiologic distribution of Enterovirus A71 (EV-A71), Coxsackievirus A16 (CV-A16) and other Enteroviruses (OEV) for severe HFMD cases and the included cases were distributed among seven geographic regions (Northeast, North China, Northwest, Central China, Southwest, East China and South China)...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28011278/molecular-characterization-of-echovirus-13-uncovering-high-genetic-diversity-and-identification-of-new-genotypes-in-pakistan
#10
Shahzad Shaukat, Mehar Angez, Tariq Mahmood, Muhammad Masroor Alam, Salmaan Sharif, Adnan Khurshid, Muhammad Suleman Rana, Syed Sohail Zahoor Zaidi
Echovirus 13 (E-13) is reported worldwide and is mostly related to aseptic meningitis but it is also isolated from cases of acute flaccid paralysis (AFP). Unfortunately, all studies conducted on non polio enterovirus in Pakistan only confirm E-13 isolation based on microneutralization assay but there is lack of molecular epidemiological data on this serotype. In this study, 113 stool samples were collected from AFP patients during 2008-2010. An enterovirus primer mediated real-time reverse transcriptase polymerase chain reaction, a standard microneutralization assay and sequencing of viral protein 1 gene (VP1) identified the predominant serotype E-13...
December 20, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28007669/a-case-of-aseptic-meningitis-without-neck-rigidity-occurring-in-a-metastatic-melanoma-patient-treated-with-ipilimumab
#11
Kyosuke Oishi, Masaharu Nakao, Shintaro Maeda, Takashi Matsushita, Tokuhei Ikeda, Tadaaki Yamada, Kazuhiko Takehara, Yasuhito Hamaguchi
No abstract text is available yet for this article.
December 22, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27976418/semiparametric-time-varying-coefficient-model-for-matched-case-crossover-studies
#12
Ana Maria Ortega-Villa, Inyoung Kim, H Kim
In matched case-crossover studies, it is generally accepted that the covariates on which a case and associated controls are matched cannot exert a confounding effect on independent predictors included in the conditional logistic regression model. This is because any stratum effect is removed by the conditioning on the fixed number of sets of the case and controls in the stratum. Hence, the conditional logistic regression model is not able to detect any effects associated with the matching covariates by stratum...
December 15, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27957363/aseptic-meningitis-caused-by-lassa-virus-case-series-report
#13
Peter O Okokhere, Idowu A Bankole, Christopher O Iruolagbe, Benard E Muoebonam, Martha O Okonofua, Simeon O Dawodu, George O Akpede
The Lassa virus is known to cause disease in different organ systems of the human body, with varying clinical manifestations. The features of severe clinical disease may include bleeding and/or central nervous system manifestations. Whereas Lassa fever encephalopathy and encephalitis are well described in the literature, there is paucity of data on Lassa virus meningitis. We present the clinical description, laboratory diagnosis, and management of 4 consecutive cases of aseptic meningitis associated with Lassa virus infection without bleeding seen in a region of Nigeria known to be endemic for both the reservoir rodent and Lassa fever...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27955629/cerebellar-ataxia-due-to-leptospirosis-a-case-report
#14
Rajveer Singh, Dheeraj Khurana, Sahil Mehta, Aditya Choudhary, Gayathri Petluri, Vivek Lal
BACKGROUND: Leptospirosis involves nervous system in around 10-15% of the cases, the commonest presentation being aseptic meningitis. Most of the clinical features of neuroleptospirosis are due to capillary endothelial damage and vasculitis. Ataxia is an extremely uncommon manifestation of Leptospirosis occuring in <5% of cases. CASE PRESENTATION: A 28 year old female from North India presented with a short febrile illness followed by an acute onset cerebellar ataxia, anemia, thrombocytopenia and transaminitis...
December 12, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27930588/three-cases-of-mumps-virus-and-enterovirus-coinfection-in-children-with-enteroviral-meningitis
#15
Mojtaba Rasti, Manoochehr Makvandi, Niloofar Neisi, Azarakhsh Azaran, Nasrin Rastegarvand, Davod Khalafkhany, Emad Jahangirnezhad, Ali Teimoori, Maryam Hadian, Abdolnabi Shabani, Ahmad Shamsizadeh, Roya Nikfar, Mehran Varnaseri
Several viruses are responsible for aseptic meningitis; however, in the region of Southwest Iran, the role played by each virus is still not very well known. The aim of this study is to determine the relative frequencies of mumps virus, herpes viruses, and enteroviruses, as well as coinfections among them, in patients with aseptic meningitis.In this cross-sectional study, samples of cerebrospinal fluid were collected between December 2012 and December 2013 from patients under 14 years, who were hospitalized in Abuzar Children's Hospital in Ahvaz, Southwest Iran (the only children's hospital in Khuzestan province and Southwest Iran)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27927236/chronic-infantile-neurological-cutaneous-and-articular-cinca-syndrome-a-review
#16
REVIEW
Martina Finetti, Alessia Omenetti, Silvia Federici, Roberta Caorsi, Marco Gattorno
INTRODUCTION: The Chronic Infantile Neurological Cutaneous and Articular (CINCA, or Neonatal-onset multisystem inflammatory disease NOMID) is a rare autoinflammatory disease identified in 1987 by Prieur et al., typically characterized by the triad of skin rash, arthropathy and central nervous system manifestations. It represents the most severe phenotype of the cryopyrin-associated periodic syndrome (CAPS). CLINICAL DESCRIPTION AND ETIOLOGY: The syndrome is due to autosomal dominant gain of function mutations in NLRP3, which encodes a key component of the innate immunity that regulates the activation and secretion of interleukin (IL)-1β...
December 7, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27919639/-evaluation-of-an-xpert-ev-cepheid-%C3%A2-molecular-diagnostic-technique-for-enteroviral-meningitis
#17
Natalia Alonso Pérez, Belén Sagastizabal Cardelus, Luis Manuel Prieto Tato, Sara Guillén Martín, Ana González Torralba, Isabel García Bermejo, José Tomás Ramos Amador
INTRODUCTION: Polymerase chain reaction (PCR) assays have shown to be useful and quick for the diagnosis of enterovirus in aseptic meningitis. The aim of our study was to analyse the changes in clinical practice after the introduction of a real-time polymerase chain reaction (RT-PCR) technique using the Xpert EV (Cepheid(®)) assay for the qualitative detection of enterovirus RNA in cerebrospinal fluid specimens from children with suspected viral meningitis. METHODS: A retrospective study was performed in children older than 1year, diagnosed with enterovirus meningitis in a third level hospital from November 2006 to February 2013...
December 2, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27916923/associations-between-meteorological-factors-and-aseptic-meningitis-in-six-metropolitan-provinces-of-the-republic-of-korea
#18
Yadav Prasad Joshi, Eun-Hye Kim, Jong-Hun Kim, Ho Kim, Hae-Kwan Cheong
We assessed the association between climate factors and a number of aseptic meningitis cases in six metropolitan provinces of the Republic of Korea using a weekly number of cases from January 2002 to December 2012. Generalized linear quasi-Poisson models were applied to estimate the effects of climate factors on the weekly number of aseptic meningitis cases. We used generalized additive and generalized additive mixed models to assess dose-response relationships. A 1 °C increase in mean temperature was associated with an 11...
November 30, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27907970/-epidemiology-etiology-and-clinical-picture-of-enteroviral-meningitis-in-children-in-south-moravia
#19
Adriana Braunová, Petra Rainetová, Lenka Krbková, Iva Čapovová, Lenka Klapačová, Václav Musil, Martin Musílek, Jana Bednářová
OBJECTIVES: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. MATERIAL AND METHODS: A total of 88 children with EV meningitis were prospectively evaluated...
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27898578/risk-classification-for-enteroviral-infection-in-children-with-meningitis-and-negative-gram-stain
#20
Ramia Zakhour, Elizabeth Aguilera, Rodrigo Hasbun, Susan H Wootton
OBJECTIVES: Enterovirus is the most common cause of aseptic meningitis in children. This study aimed at identifying baseline variables associated with a positive cerebrospinal fluid (CSF) Enterovirus polymerase chain reaction (PCR) to aid clinicians in targeting patients who could be tested and treated as outpatients. METHODS: We performed a retrospective review of children (2 months to 17 years old) admitted to the Children's Memorial Hermann Hospital in Houston, TX, between January 2005 and December 2010 with symptoms of meningitis, CSF white cell count of greater than 5 cells/mm, and a negative CSF Gram stain, who had a CSF Enterovirus PCR...
November 24, 2016: Pediatric Emergency Care
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