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Aseptic meningitis

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https://www.readbyqxmd.com/read/27907970/-epidemiology-etiology-and-clinical-picture-of-enteroviral-meningitis-in-children-in-south-moravia
#1
Adriana Braunová, Petra Rainetová, Lenka Krbková, Iva Čapovová, Lenka Klapačová, Václav Musil, Martin Musílek, Jana Bednářová
OBJECTIVES: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. MATERIAL AND METHODS: A total of 88 children with EV meningitis were prospectively evaluated...
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27898578/risk-classification-for-enteroviral-infection-in-children-with-meningitis-and-negative-gram-stain
#2
Ramia Zakhour, Elizabeth Aguilera, Rodrigo Hasbun, Susan H Wootton
OBJECTIVES: Enterovirus is the most common cause of aseptic meningitis in children. This study aimed at identifying baseline variables associated with a positive cerebrospinal fluid (CSF) Enterovirus polymerase chain reaction (PCR) to aid clinicians in targeting patients who could be tested and treated as outpatients. METHODS: We performed a retrospective review of children (2 months to 17 years old) admitted to the Children's Memorial Hermann Hospital in Houston, TX, between January 2005 and December 2010 with symptoms of meningitis, CSF white cell count of greater than 5 cells/mm, and a negative CSF Gram stain, who had a CSF Enterovirus PCR...
November 24, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27884454/-management-of-adverse-effects-related-to-human-immunoglobulin-therapy-recommendations-for-clinical-practice
#3
I Marie, P Chérin, M Michallet, E Pelus, J Dantal, J-C Crave, J-C Delain, J-F Viallard
Both intravenous and subcutaneous immunoglobulins are therapeutic modalities approved in various conditions, including primary and secondary immune deficiencies and autoimmune disorders. To date, immunoglobulins have more often been considered as a safe medication, with minor adverse effects such as hypertension, fever and chills, nausea, myalgia or headache. However, with the wider use of immunoglobulins in the treatment of autoimmune diseases, severe side effects have also been reported to occur in immunoglobulin-treated patients, especially anaphylaxis, aseptic meningitis, acute renal impairment, thrombotic events as well as haematological manifestations...
November 21, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27826325/enterovirus-71-infection-and-neurological-complications
#4
REVIEW
Kyung Yeon Lee
Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and usually resolves spontaneously. However, EV71 occasionally involves the central nervous system (CNS), and induces diverse neurological complications such as brainstem encephalitis, aseptic meningitis, and acute flaccid paralysis...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27807853/aseptic-meningitis-following-therapy-with-immune-globulins-a-combination-of-product-features-and-patient-characteristics
#5
Roger Berg, Elisabeth Fuellenhals
BACKGROUND: Aseptic meningitis (AM) represents a recognized side effect of immune globulin (IG) therapy and may warrant additional diagnostic procedures and therapy with anti-infective drugs until a definite diagnosis can be established. Although, to date, only small case series have been published, the objective of the current study was to investigate a large case series of patients with AM. STUDY DESIGN AND METHODS: The pharmacovigilance safety database of a 10% liquid IG (Gammagard Liquid) was queried for all reports of AM...
November 2, 2016: Transfusion
https://www.readbyqxmd.com/read/27789638/complete-genome-sequence-analysis-of-echovirus-18-associated-with-aseptic-meningitis-in-hebei-province-china-in-2015
#6
Xiang-Peng Chen, Su-Zhen Sun, Jia-Yun Guo, Jing-Jie Li, Zheng-de Xie
Echovirus 18 is a member of the genus Enterovirus, family Picornaviridae, which can cause meningitis in children. Here, we report the echovirus 18 complete genome sequence, which was isolated from the cerebrospinal fluid of a child with aseptic meningitis in Hebei Province, China.
October 27, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27789515/fifteen-minute-consultation-enterovirus-meningitis-and-encephalitis-when-can-we-stop-the-antibiotics
#7
Simon B Drysdale, Dominic F Kelly
Enterovirus (EV) is the most common cause of aseptic meningitis and has a benign course, unlike EV encephalitis, which can result in long-term neurological sequelae. There are no active treatments or prophylactic agents, and management is purely supportive. Obtaining an EV-positive cerebrospinal fluid result usually allows antimicrobial treatment to be stopped. This review will answer some of the common questions surrounding EV meningitis/encephalitis.
October 27, 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27773908/herpes-simplex-virus-type-2-associated-recurrent-aseptic-meningitis-mollaret-s-meningitis-with-a-recurrence-after-11-year-interval-a-case-report
#8
Yoshitsugu Nakamura, Hideto Nakajima, Yosuke Kano, Kiichi Unoda, Shimon Ishida, Fumiharu Kimura
A 55-year-old woman was diagnosed with aseptic meningitis at the age of 43 and 44. She developed sudden fever and headache, and she showed nuchal rigidity. Cerebrospinal fluid examination revealed pleocytosis (cell count 208/mm(3)) and was positive for herpes simplex virus type 2 (HSV-2) DNA by PCR. Acyclovir was started on the first day of admission, and she was complete recovery. Preserved cerebrospinal fluid specimen from aseptic meningitis at the age of 44 was also positive for HSV-2 DNA by PCR. She was diagnosed with HSV-2 associated recurrent aseptic meningitis (Mollaret's meningitis) with a recurrence after 11-year interval...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27736668/blood-csf-barrier-dysfunction-is-a-marker-for-encephalitic-involvement-in-patients-with-aseptic-meningitis-meningoencephalitis
#9
C Hoyer, P Eisele, A D Ebert, S Schneider, A Gass, M Fatar, K Szabo, A Alonso
BACKGROUND: The term "aseptic meningitis" encompasses cases of meningitis with negative bacterial CSF culture, which predominantly are of viral etiology. While the clinical course is usually benign, complications such as encephalitic involvement resulting in a more severe clinical course may occur. Dysfunction of the blood-brain-barrier (BBB), which is a prerequisite for viral entry into the brain parenchyma, can be approximated using the CSF/serum albumin ratio, readily obtainable in routine CSF analysis...
October 6, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27736044/molecular-characterization-of-environmental-and-clinical-echovirus-6-isolates-from-poland-2006-2014
#10
Magdalena Wieczorek, Arleta Krzysztoszek, Agnieszka Ciąćka, Agnieszka Figas
The aim of this study was to investigate the genetic variability of echovirus 6 (E6) isolates from environmental samples and clinical cases of aseptic meningitis from 2006 to 2014. The analysis of the VP1 region showed the extensive diversity (up to 18.8%) and revealed that E6 circulating in Poland belong to four groups. Environmental strains clustered in three groups excepting the 2012 outbreak group, which shows the sudden introduction of new epidemic variant with Asiatic origin. Data from the study established relationships of E6 from Poland with previously characterized strains and confirmed the importance of both clinical and environmental surveillance...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27722072/aseptic-meningitis-with-craniopharyngioma-resection-consideration-after-endoscopic-surgery
#11
Jenny X Chen, Blake C Alkire, Allen C Lam, William T Curry, Eric H Holbrook
Objectives While bacterial meningitis is a concerning complication after endoscopic skull base surgery, the diagnosis can be made without consideration for aseptic meningitis. This article aims to (1) present a patient with recurrent craniopharyngioma and multiple postoperative episodes of aseptic meningitis and (2) discuss the diagnosis and management of aseptic meningitis. Design Case report and literature review. Results A 65-year-old female patient with a symptomatic craniopharyngioma underwent transsphenoidal resection...
October 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27709866/relapsing-polychondritis-with-central-nervous-system-involvement-experience-of-three-different-cases-in-a-single-center
#12
Chan Hong Jeon
Relapsing polychondritis (RP) is an autoimmune disorder characterized by inflammation in cartilaginous structures including the ears, noses, peripheral joints, and tracheobronchial tree. It rarely involves the central nervous system (CNS) but diagnosis of CNS complication of RP is challenging because it can present with varying clinical features. Herein we report 3 cases of relapsing polychondritis involving CNS with distinct manifestations and clinical courses. The first patient presented with rhombencephalitis resulting in brain edema and death...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27709402/molecular-characterization-of-a-new-human-coxsackievirus-b2-associated-with-severe-hand-foot-mouth-disease-in-yunnan-province-of-china-in-2012
#13
Jie Zhang, Haihao Zhang, Yilin Zhao, Chen Guo, Zhaoqing Yang, Shaohui Ma
Human coxsackievirus B2 (CVB2) belongs to the species Human enterovirus B and can cause aseptic meningitis, myocarditis and hand-foot-mouth disease (HFMD). We first determined the complete genome of the RW41-2/YN/CHN/2012 strain, isolated from a patient with HFMD and aseptic meningitis in the Yunnan Province, China in 2012. The strain shared 83.5 % and 82.2 % nucleotide similarity with CVB2 prototype strain Ohio-1, in the complete VP1 gene and the complete genome, respectively. Using phylogenetic and homogeneity analyses for the complete VP1 gene, CVB2 strains could be divided into four genogroups (A-D); the RW41-2/YN/CHN/2012 strain belonging to genogroup D...
October 1, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27707729/diagnostic-criteria-for-cryopyrin-associated-periodic-syndrome-caps
#14
Jasmin B Kuemmerle-Deschner, Seza Ozen, Pascal N Tyrrell, Isabelle Kone-Paut, Raphaela Goldbach-Mansky, Helen Lachmann, Norbert Blank, Hal M Hoffman, Elisabeth Weissbarth-Riedel, Boris Hugle, Tilmann Kallinich, Marco Gattorno, Ahmet Gul, Nienke Ter Haar, Marlen Oswald, Fatma Dedeoglu, Luca Cantarini, Susanne M Benseler
Cryopyrin-associated periodic syndrome (CAPS) is a rare, heterogeneous disease entity associated with NLRP3 gene mutations and increased interleukin-1 (IL-1) secretion. Early diagnosis and rapid initiation of IL-1 inhibition prevent organ damage. The aim of the study was to develop and validate diagnostic criteria for CAPS. An innovative process was followed including interdisciplinary team building, item generation: review of CAPS registries, systematic literature review, expert surveys, consensus conferences for item refinement, item reduction and weighting using 1000Minds decision software...
October 4, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27677851/parp-inhibition-in-leukocytes-diminishes-inflammation-via-effects-on-integrins-cytoskeleton-and-protects-the-blood-brain-barrier
#15
Slava Rom, Viviana Zuluaga-Ramirez, Nancy L Reichenbach, Holly Dykstra, Sachin Gajghate, Pal Pacher, Yuri Persidsky
BACKGROUND: Blood-brain barrier (BBB) dysfunction/disruption followed by leukocyte infiltration into the brain causes neuroinflammation and contributes to morbidity in multiple sclerosis, encephalitis, traumatic brain injury, and stroke. The identification of pathways that decreases the inflammatory potential of leukocytes would prevent such injury. Poly(ADP-ribose) polymerase 1 (PARP) controls various genes via its interaction with myriad transcription factors. Selective PARP inhibitors have appeared lately as potent anti-inflammatory tools...
September 27, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27666897/sle-neuropathy-anything-new
#16
Vikram A Londhey
SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, involuntary movements like chorea, myelopathy, acute confusional states, cognitive dysfunction, mood disorder, seizures, psychosis and cranial nerve palsies...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27652088/molecular-identification-of-human-enteroviruses-associated-with-aseptic-meningitis-in-yunnan-province-southwest-china
#17
Yanju Zhu, Xi Zhou, Jiansheng Liu, Longhui Xia, Yue Pan, Junying Chen, Na Luo, Jianzhong Yin, Shaohui Ma
Human enteroviruses (EVs) are the major causative agents of aseptic meningitis. In this study, a total of 524 children were admitted to the children Kunming hospital (continental China) for aseptic meningitis manifestations in 2009 and 2010. An EV infection was diagnosed in 85/524 children (16.2 %) and the viruses detected were assigned to 16 serotypes. Most serotypes belonged to the enterovirus B species. Echovirus 9 was predominant (24.7 %), followed by coxsackievirus B5 (23.5 %) and then echovirus 30 (16...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27646838/laboratory-diagnosis-and-genetic-analysis-of-a-family-clustering-outbreak-of-aseptic-meningitis-due-to-echovirus-30
#18
Shufa Zheng, Hongyan Ye, Juying Yan, Guoliang Xie, Dawei Cui, Fei Yu, Yiyin Wang, Xianzhi Yang, Fangman Zhou, Yanjun Zhang, Xueli Tian, Yu Chen
Echovirus 30 (E30) is a major pathogen associated with aseptic meningitis. In the summer of 2014, a family clustering aseptic meningitis outbreak occurred in urban-rural fringe of Ningbo city in Zhejiang Province in China. To identify the etiologic agent, specimens were tested by cell culture and reverse transcriptase-polymerase chain reaction. Pathogenic examination confirmed that the outbreak is caused by E30. The first case is a 6-year-old child, who studied in kindergarten in local, suffered from headache and fever...
September 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27638827/-neurosarcoidosis
#19
W Reith, S Roumia, C Popp
CLINICAL/METHODICAL ISSUE: Neurosarcoidosis is a relatively rare complication of sarcoidosis that occurs in approximately 5-15 % of patients. The clinical picture is variable. Clinically, neurosarcoidosis is mostly manifested as lesions of the cranial nerves (50-70 %) and several cranial nerves are typically affected. This is the result of aseptic granulomatous basal meningitis. Intraparenchymal granulomas also occur, frequently affecting basal near-midline structures, such as the hypothalamus and pituitary glands and can lead to encephalopathy...
October 2016: Der Radiologe
https://www.readbyqxmd.com/read/27622671/familial-mediterranean-fever-presenting-with-recurrent-aseptic-meningitis-a-case-report
#20
Dawood Yusef, Wasim Khasawneh
No abstract text is available yet for this article.
August 21, 2016: Pediatrics and Neonatology
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