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https://www.readbyqxmd.com/read/29792971/impact-of-active-surveillance-and-infection-control-measures-on-carbapenem-resistant-gram-negative-bacterial-colonization-and-infections-in-intensive-care
#1
T Karampatakis, K Tsergouli, E Iosifidis, C Antachopoulos, A Karapanagiotou, A Karyoti, N Gritsi-Gerogianni, A Tsakris, E Roilides
BACKGROUND: Carbapenem-resistant Gram-negative bacteria (CRGNB) infections constitute a global threat for critically ill patients and the outcome of their hospitalization. Early identification of CRGNB through rectal surveillance cultures and routine infection control measures including contact precautions, use of appropriate disinfectants, staff education on cleaning, and hand hygiene may reduce the dissemination of CRGNB. AIM: To assess the impact of enhanced infection control measures on CRGNB infections in a nine-bed polyvalent intensive care unit in a tertiary level hospital in an endemic area...
May 21, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29791695/current-strategies-to-prevent-iatrogenic-ureteral-injury-during-colorectal-surgery
#2
Jonathan Douissard, Frederic Ris, Philippe Morel, Nicolas Christian Buchs
Iatrogenic ureteral injuries are a source of major concern among surgeons performing colorectal procedures. Although they are uncommon, these lesions lead to severe morbidity and long-term functional disabilities, as well as an increase in mortality, hospital stay, and cost. The laparoscopic approach has gained popularity in the field of colorectal surgery and is associated with improved global postoperative outcomes. However, it is also considered to increase the risk of ureteral injury when compared to open surgery, especially during left colonic and rectal resections...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29789327/antidepressant-use-and-risk-of-colorectal-cancer-in-the-women-s-health-initiative
#3
Jenna Kiridly-Calderbank, Susan R Sturgeon, Candyce H Kroenke, Katherine W Reeves
BACKGROUND: Some prior studies have reported reduced colorectal cancer risk among individuals using antidepressant (AD) medications, especially selective serotonin reuptake inhibitors (SSRIs). Yet, most studies have not considered the potential role of depression or other confounders in their analyses. METHODS: We utilized prospectively collected data from 145,190 participants in the Women's Health Initiative, among whom 2,580 incident colorectal cancer cases were diagnosed...
May 22, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29784739/management-of-locoregional-rectal-cancer
#4
Christopher G Willett
The NCCN Guidelines for Rectal Cancer are now more closely aligned with those for colon cancer. A new MRI-based definition of the rectum has been included and the use of MRI in staging has been elevated in importance. There is a new emphasis on neoadjuvant therapy, especially the concurrent use of chemotherapy and radiotherapy. One of the biggest changes is more acceptance of an observational approach-"watch and wait, nonoperative management"-for select patients experiencing a complete clinical response with no evidence of residual disease after neoadjuvant therapy...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29783140/congenital-diaphragmatic-disease-an-unusual-presentation-in-adulthood-case-report
#5
Angela Gurrado, Roberta Maria Isernia, Alessandro De Luca, Valentina Ferraro, Daniela Virgintino, Anna Napoli, Giuseppe Cavallaro, Eugenio Maiorano, Angela Pezzolla, Mario Testini
INTRODUCTION: Congenital diaphragmatic disease is a quite common condition that usually occurs in the neonatal period, and the diagnosis of congenital diaphragmatic disease in adulthood is rare. CASE PRESENTATION: A 64-years-old Caucasian woman was admitted in emergency at our Department, due to a bowel obstruction and dyspnea. A CT-scan showed a diaphragmatic herniation in the left area, with malposition of dilated transverse and descending colon in the chest. An emergency laparatomy was performed, showing a toxic megacolon, in the absence of a true diaphragmatic hernia, and a left diaphragm and left liver hypoplasia...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29781837/recommendations-on-rectal-surveillance-for-colorectal-cancer-after-subtotal-colectomy-in-patients-with-inflammatory-bowel-disease
#6
Lauranne A A P Derikx, Michiel E de Jong, Frank Hoentjen
Approximately 30% of patients with ulcerative colitis require a colectomy during their disease course. This substantially reduces colorectal cancer risk, although it is still possible to develop colorectal neoplasia in the remaining rectum. Although clear and well-accepted surveillance guidelines exist for patients with inflammatory bowel disease with an intact colon, specific surveillance recommendations following colectomy are less clear. Here, we aim to summarize the prevalence, incidence, and risk factors for developing colorectal cancer in patients with inflammatory bowel disease who underwent subtotal colectomy with a permanent end ileostomy and rectal stump, or with ileorectal anastomosis...
May 17, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29779798/identification-of-factors-predictive-of-postoperative-morbidity-and-short-term-mortality-in-older-patients-after-colorectal-carcinoma-resection-a-single-center-retrospective-study
#7
Teresa Schreckenbach, Matthias Valentin Zeller, Hanan El Youzouri, Wolf Otto Bechstein, Guido Woeste
OBJECTIVES: The aim of this study is to investigate the effect of age on patient outcome after colorectal carcinoma (CRC) resection in patients over 65 years of age. METHODS: This study included patients aged 65 years and older who underwent CRC resection between 2003 and 2013 at a single-center institution. Patients were divided into two groups: Group A (65-74 years old) and Group B (≥75 years old). RESULTS: Multivariable logistic analysis of 415 patients revealed serum albumin levels on the third postoperative day (POD) (Odds Ratio (OR), 0...
May 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29778632/how-to-save-both-transverse-colon-and-continence-after-extensive-left-colon-surgery-a-case-report-of-a-new-procedure
#8
Marica Grasso, Alessandro Cimmino, Nicola Sangiuliano, Antonello Niglio
INTRODUCTION: Nowadays, after wide left colectomy, it is necessary to choose one of the following procedures: a definitive transverse colostomy, an ileo-rectal anastomosis or a right colo-rectal anastomosis (Deloyers procedure). PRESENTATION OF CASE: We performed our new procedure on a 63 years-old man. After an extensive left proctocolectomy, the intestinal continuity between the transverse colon and rectum was obtained by transposition and rotation of the right colon into the pelvis...
April 21, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29778131/vitamin-d-receptor-level-in-biopsy-specimen-of-patients-with-ulcerative-colitis-results-from-a-center-in-western-anatolia
#9
Adil Coskun, Irfan Yavasoglu, Ibrahim Meteoglu, Mustafa Unubol, Burak Yasar, Serkan Borazan, Imran Kurt Omurlu, Vahit Yukselen, M Hadi Yasa
BACKGROUND: Ulcerative colitis (UC) is a chronic, inflammatory bowel diseases characterized by uncontrolled inflammatory condition of the colon and rectal mucosa marked by recurrent periods of remission and exacerbation. Vitamin D receptor (VDR) is a member of the steroid receptor family that mediates the effects of vitamin D by regulating transcription of multiple cellular genes. We aimed to evaluate vitamin d receptor level in biopsy specimen of patients with UC in this study. METHODS: VDR levels were retrospectively studied in colon biopsy specimens of UC patients...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29775230/alcohol-enhances-symptoms-and-propensity-for-infection-in-inflammatory-bowel-disease-patients-and-a-murine-model-of-dss-induced-colitis
#10
Abigail R Cannon, Paulius V Kuprys, Adrienne N Cobb, Xianzhong Ding, Anai N Kothari, Paul C Kuo, Joshua M Eberhardt, Adam M Hammer, Niya L Morris, Xiaoling Li, Mashkoor A Choudhry
Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammation, rectal bleeding, and dehydration. Interestingly, a widespread recommendation to IBD patients for avoidance of a flare period is "Don't Drink Alcohol" as recent work correlated alcohol consumption with increased GI symptoms in patients with IBD...
May 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29771800/left-sided-dominance-of-early-onset-colorectal-cancers-a-rationale-for-screening-flexible-sigmoidoscopy-in-the-young
#11
Lior Segev, Matthew F Kalady, James M Church
BACKGROUND: National databases show a recent significant increase in the incidence of colorectal cancer in people younger than 50. With current recommendations to begin average-risk screening at age 50, these patients do not have the opportunity to be screened. We hypothesized that most of the cancers among the young would be left sided, which would create an opportunity for screening the young by flexible sigmoidoscopy. OBJECTIVE: This study aims to analyze the anatomic distribution of sporadic colorectal cancers in patients under the age of 50...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29770759/milk-and-risk-of-colorectal-colon-and-rectal-cancer-in-the-norwegian-women-and-cancer-nowac-cohort-study
#12
Toril Bakken, Tonje Braaten, Anja Olsen, Anette Hjartåker, Eiliv Lund, Guri Skeie
According to World Cancer Research Fund International/American Institute for Cancer Research, it is 'probable' that dairy products decrease the risk of colorectal cancer (CRC). However, meta-analyses restricted to women have not shown associations between milk intake and risk of CRC. The aim of this study was to examine the association between milk intake and risk of CRC, colon cancer and rectal cancer among women. Data from 81 675 participants in the Norwegian Women and Cancer Cohort Study were included, and multivariable Cox proportional hazard regression models were used to investigate milk intake using two different analytical approaches: one that included repeated measurements and one that included baseline measurements only (872 and 1084 CRC cases, respectively)...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29769508/total-colonic-duplication-associated-with-anorectal-malformation-in-a-male-boy
#13
L H Chowdhury, U K Nag, N A Sheuli, U Roy
Complete colorectal tubular duplication is very rare congenital anomaly and its association with anorectal malformation is extremely rare. Preoperative diagnosis is very difficult and management is also challenging. We report a case of a newborn present as a bucket handle variety of anorectal malformation which was per-operatively diagnosed as an ARM with rectal duplication. At his 14th months of age on laparotomy patient was diagnosed as a case of ARM with total colonic duplication with single appendix. We managed the case successfully without extensive bowel resection in staged procedure...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29766204/adiponectin-administration-alleviates-dss-induced-colonic-inflammation-in-caco-2-cells-and-mice
#14
Qin Zhao, Yang Liu, Lei Tan, Liyong Yan, Xiuli Zuo
BACKGROUND: Adiponectin, a protein hormone produced by adipose tissues, exhibits anti-inflammatory functions in various models. This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in Caco-2 cell and mice. MATERIALS AND METHODS: The results showed that DSS caused inflammatory response and intestinal barrier dysfunction in vitro and in vivo. Adiponectin injection alleviated colonic injury and rectal bleeding in mice...
May 15, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29761424/dietary-intake-of-total-polyphenol-and-polyphenol-classes-and-the-risk-of-colorectal-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-cohort
#15
Raul Zamora-Ros, Valerie Cayssials, Mazda Jenab, Joseph A Rothwell, Veronika Fedirko, Krasimira Aleksandrova, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Marie-Christine Boutron-Ruault, Franck Carbonnel, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elissavet Valanou, Effie Vasilopoulou, Giovanna Masala, Valeria Pala, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Elisabete Weiderpass, Marko Lukic, Torkjel M Sandanger, Cristina Lasheras, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Bodil Ohlsson, Lena Maria Nilsson, Martin Rutegård, Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Kathryn Bradbury, Heinz Freisling, Isabelle Romieu, Amanda J Cross, Paolo Vineis, Augustin Scalbert
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries...
May 15, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29757939/heterogeneity-in-the-relationship-between-disinfection-by-products-in-drinking-water-and-cancer-a-systematic-review
#16
Tarik Benmarhnia, Ianis Delpla, Lara Schwarz, Manuel J Rodriguez, Patrick Levallois
The epidemiological evidence demonstrating the effect of disinfection by-products (DBPs) from drinking water on colon and rectal cancers is well documented. However, no systematic assessment has been conducted to assess the potential effect measure modification (EMM) in the relationship between DBPs and cancer. The objective of this paper is to conduct a systematic literature review to determine the extent to which EMM has been assessed in the relationship between DBPs in drinking water in past epidemiological studies...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29756117/endoscopic-repair-of-rectal-perforation-due-to-colonoscopy-with-a-clamp-method
#17
Osman Köneş, Cevher Akarsu, Tarık Acar, Halil Alış
Colon perforation during colonoscopy is a rare complication that usually requires surgical intervention. Traditionally, primary repair by laparoscopy, laparotomy, resection, and anastomosis is performed for such perforations. More recently developed minimally invasive endoscopic instruments have also been used in the repair of these perforations; this is becoming increasingly common. An endoscopic over-the-scope clip clamp was used in a 59-year-old male patient who suffered a rectum perforation in connection with a diagnostic colonoscopy...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29755761/distinctive-features-of-gastrointestinal-stromal-tumors-arising-from-the-colon-and-rectum
#18
Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Pérez-Irizarry, Charles H Cha, Caroline H Johnson, Daniel J Boffa, Dale Han, Kimberly L Johung, Yawei Zhang, Sajid A Khan
Background: Colon and rectal gastrointestinal stromal tumors (GISTs) are rare and poorly characterized. Because the majority of treatment guidelines for GISTs are extrapolated from tumors of gastric and small bowel origin, our aim was to better characterize the unique clinicopathologic features and prognostic factors of colon and rectal GISTs to guide clinical care. Methods: The National Cancer Data Base (NCDB) was queried from 2006 to 2013 for cases of GISTs in the stomach, colon, and rectum...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755106/a-rare-case-of-adult-onset-rectosigmoid-hypoganglionosis
#19
Mohammed Yousef Aldossary, Antonio Privitera, Obai Elzamzami, Nemat Alturki, Khalid Sabr
BACKGROUND Intestinal hypoganglionosis is very rare and accounts for 3% to 5% of all classified congenital intestinal innervation disorders. Isolated hypoganglionosis of the colon is a particularly rare form of the disease, and differential diagnosis includes association with Hirschsprung's disease and chronic intestinal pseudo-obstruction (CIPO) related to visceral myopathies. Most cases are diagnosed at an early age or in childhood with only a few cases reported in adults. CASE REPORT We report a case of isolated hypoganglionosis of the rectum and sigmoid presenting as an emergency with acute intestinal obstruction in a 20-year-old male patient...
May 14, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29754212/matrix-metalloproteinase-expression-is-altered-in-the-small-and-large-intestine-following-fractionated-radiation-in-vivo
#20
Romany L Stansborough, Noor Al-Dasooqi, Emma H Bateman, Joanne M Bowen, Dorothy M K Keefe, Richard M Logan, Ann S J Yeoh, Eric E K Yeoh, Andrea M Stringer, Rachel J Gibson
PURPOSE: Radiotherapy-induced gut toxicity (RIGT) is associated with significant diarrhoea, pain and rectal bleeding. Matrix metalloproteinases (MMPs) have been reported to be involved in chemotherapy-induced gut toxicity and RIGT following single-dose irradiation in vivo. We therefore proposed MMPs would be involved in the pathobiology of RIGT following fractionated irradiation. METHODS: Dark Agouti rats were treated with fractionated radiation (3 × 2.5 Gy/week for 6 weeks)...
May 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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