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https://www.readbyqxmd.com/read/27873529/tracheal-allotransplantation-and-regeneration
#1
P Delaere, M Molitor
Non-malignant and malignant obstruction of the tracheal airway causes significant morbidity and mortality. With increased use of artificial airways, benign and iatrogenic complications are increasing. A tracheal stenosis that is less than 5 cm in length can be resected with end-to-end anastomosis. Longer tracheal lesions can be treated in a palliative way by placement of a stent to secure airway lumen patency. The management of tracheal defects is an evolving field. Tracheal transplantation and tracheal regeneration may provide major treatment advances to cases with long-segment tracheal involvement...
2016: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27870822/comparison-of-total-lung-capacity-determined-by-plethysmography-with-computed-tomographic-segmentation-using-caliper
#2
Andrew J Matsumoto, Brian J Bartholmai, Mark E Wylam
PURPOSE: Traditionally, determination of total lung capacity (TLC) by plethysmography (TLCpleth) has been important in the diagnosis of lung diseases. Alternatively, data acquired from computerized tomography (CT) can be utilized to calculate a measure of TLC (TLCCT). The clinical utility of TLCCT is not certain. We sought to determine, in a clinical setting, whether TLCCT correlates with TLCpleth across a range of lung diseases and scanning techniques. In addition, we determined whether TLCCT affects the interpretation of pulmonary function tests...
November 18, 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27811563/systemic-fungal-infections-in-donors-for-corneal-transplantation
#3
Sheila Pabon, Thomas D Lindquist, Thomas D Miller, Bennie H Jeng
PURPOSE: To determine the prevalence of postkeratoplasty fungal infection when corneal tissue from donors with a recent medical history of oral thrush or respiratory, urine, wound, sputum, bronchial, tracheal, or throat culture positive for fungus is identified before recovery and after decontamination of the corneal tissue with 5% povidone-iodine flush to the donors' eyes during recovery. METHODS: This is a prospective analysis of corneas from 42 donors with a documented medical history of fungus or positive fungal culture, which were recovered between January 2010 and November 2010...
November 2, 2016: Cornea
https://www.readbyqxmd.com/read/27804215/simultaneously-targeting-myofibroblast-contractility-and-extracellular-matrix-cross-linking-as-a-therapeutic-concept-in-airway-fibrosis
#4
Yu-Chun Lin, Yon K Sung, Xinguo Jiang, Marc Peters-Golden, Mark R Nicolls
Fibrosis after solid organ transplantation is considered an irreversible process and remains the major cause of graft dysfunction and death with limited therapies. This remodeling is characterized by aberrant accumulation of contractile myofibroblasts that deposit excessive extracellular matrix (ECM) and increase tissue stiffness. However, studies demonstrate that a stiff ECM, itself, promotes fibroblast-to-myofibroblast differentiation, stimulating further ECM production. This creates a positive feedback loop that perpetuates fibrosis...
November 2, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27788126/3d-printed-polyurethane-prosthesis-for-partial-tracheal-reconstruction-a-pilot-animal-study
#5
Soo Yeon Jung, Sang Jin Lee, Ha Yeong Kim, Hae Sang Park, Zhan Wang, Hyun Jun Kim, James J Yoo, Sung Min Chung, Han Su Kim
A ready-made, acellular patch-type prosthesis is desirable in repairing partial tracheal defects in the clinical setting. However, many of these prostheses may not show proper biological integration and biomechanical function when they are transplanted. In this study, we developed a novel 3D printed polyurethane (PU) tracheal scaffold with micro-scale architecture to allow host tissue infiltration and adequate biomechanical properties to withstand physiological tracheal condition. A half-pipe shaped PU scaffold (1...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27780343/gene-editing-and-genetic-lung-disease-basic-research-meets-therapeutic-application
#6
Deepthi Alapati, Edward E Morrisey
While our understanding of the genetics and pathology of congenital lung diseases such as surfactant protein deficiency, cystic fibrosis and alpha 1 antitrypsin deficiency is extensive, treatment options are lacking. Since the lung is a barrier organ in direct communication with the external environment, targeted delivery of gene corrective technologies to the respiratory system via intra-tracheal or intranasal routes is an attractive option for therapy. CRISPR/Cas9 gene editing technology is a promising approach to repair or inactivate disease causing mutations...
October 25, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27713198/-the-history-and-development-of-experimental-rodent-models-of-chronic-lung-allograft-dysfunction-after-lung-transplantation
#7
Hidemi Suzuki, Atsushi Hata, Yuki Shina, Takamasa Yun, Kazuhisa Tanaka, Yuichi Sakairi, Hironobu Wada, Taiki Fujiwara, Takahiro Nakajima, Takekazu Iwata, Masako Chiyo, Shigetoshi Yoshida, Ichiro Yoshino
Chronic lung allograft dysfunction (CLAD) is a critical impediment to the long-term survival after lung transplantation. A rat orthotopic lung transplantation model was developed in the early 1970s, and using this model, our laboratory has shown that the immunopathogenesis of CLAD involves both allogeneic immunity and autoimmunity. However, further investigation of CLAD is limited by the scarcity of transgenic and knockout strains. The model most widely used to study CLAD, the mouse model of heterotopic tracheal transplantation, has some incomplete pathophysiologic features of CLAD, which limits the utility of this model...
October 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27696973/tracheal-tissue-engineering-in-vivo-biocompatibility-of-mechanically-stripped-allogenic-rabbit-trachea-with-autologous-epithelial-covering
#8
Margot Den Hondt, Bart M Vanaudenaerde, Erik K Verbeken, Jan J Vranckx
BACKGROUND: Successful trachea transplantation comprises the use of biocompatible constructs with little immune-reactivity, submucosal revascularization and creation of an epithelial covering. Allogenic chondrocytes might be protected from an overt immune-response due to physical isolation. Our aim was to evaluate in-vivo biocompatibility of allotracheae, stripped of their highly-immunogenic inner lining. Secondly, we established whether these constructs might serve as suitable scaffolds for autologous epithelial grafting...
October 4, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27631002/applications-of-chondrocyte-based-cartilage-engineering-an-overview
#9
REVIEW
Abdul-Rehman Phull, Seong-Hui Eo, Qamar Abbas, Madiha Ahmed, Song Ja Kim
Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs) differentiation to chondrocytes. The number of chondrocytes and dedifferentiation are the key limitations in subsequent clinical application of the chondrocytes. Different culture methods are being developed to overcome such issues. Using tissue engineering and cell based approaches, chondrocytes offer prominent therapeutic option specifically in orthopedics for cartilage repair and to treat ailments such as tracheal defects, facial reconstruction, and urinary incontinence...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27614085/orthotopic-tracheal-transplantation-using-human-bronchus-an-original-xenotransplant-model-of-obliterative-airway-disorder
#10
Julien Guihaire, Ryo Itagaki, Mandy Stubbendorff, Xiaoqin Hua, Tobias Deuse, Sebastian Ullrich, Elie Fadel, Peter Dorfmüller, Robert C Robbins, Hermann Reichenspurner, Udo Schumacher, Sonja Schrepfer
Bronchiolitis obliterans syndrome (BOS) is a main cause of allograft dysfunction and mortality after lung transplantation (LTx). A better understanding of BOS pathogenesis is needed to overcome this treatment-refractory complication. Orthotopic tracheal transplantation using human bronchus was performed in Brown Norway (BN) and nude (RNU) rats. Allografts were recovered in both strains at Day 7 (BN7 , n = 6; RNU7 , n = 7) or Day 28 (BN28 , n = 6; RNU28 , n = 6). Immune response of the host against the bronchial graft was assessed...
September 10, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27590486/reduction-of-obliterative-bronchiolitis-ob-by-prolyl-hydroxylase-inhibitors-activating-hypoxia-inducible-transcription-factors-in-an-experimental-mouse-model
#11
Christian Heim, Benjamin Motsch, Sabina Jalilova, Wanja M Bernhardt, Martina Ramsperger-Gleixner, Nicolai Burzlaff, Michael Weyand, Kai-Uwe Eckardt, Stephan M Ensminger
BACKGROUND: Obliterative bronchiolitis (OB) is the major limiting factor for long-term survival after lung transplantation. As previously shown, donor treatment with a PHD-inhibitor activating hypoxia-inducible transcription factors (HIFs) prevents graft injury both in an allogenic kidney and aortic allograft transplant model. The aim of this study was to investigate the effect of HIF activation with a PHD-inhibitor on the development of OB. METHODS: Fully MHC-mismatched C57BL/6 (H-2(b)) donor tracheas were orthotopically transplanted into CBA/J (H-2(k)) recipients...
November 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27575658/endoscopic-peroral-jejunal-fecal-microbiota-transplantation
#12
Alexander Link, Tim Lachmund, Christian Schulz, Jochen Weigt, Peter Malfertheiner
BACKGROUND: Fecal microbiota transplantation (FMT) is a valuable treatment modality for recurrent Clostridium difficile (C. difficile) colitis. Multiple questions including the best delivery route and volume remain unanswered. Here, we report a case series of high-volume FMT using endoscopic jejunal application route. METHODS: In prospective observational study, FMT was performed using fresh specimen from healthy unrelated donors to the patients with recurrent or refractory C...
November 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27556147/percutaneous-dilatation-tracheostomy-in-patients-with-left-ventricular-assist-device-and-established-phenprocoumon-therapy
#13
Andreas Schaefer, Yvonne Schneeberger, Daniel Reichart, Alexander M Bernhardt, Mathias Kubik, Markus J Barten, Florian M Wagner, Stefan Kluge, Hermann Reichenspurner, Sebastian A Philipp
Over the last decade the number of heart transplantations declined and the number of implanted left ventricular assist devices (LVAD) markedly increased. Accordingly, common intensive care interventions rise and present their own challenges, especially due to the necessary anticoagulation regimen. One of these procedures is percutaneous dilatation tracheostomy (PDT). We herein report our experience with 34 patients with LVAD and established phrenprocoumon therapy (INR 2.1 ± 0.9, PTT 68.9 ± 19.0 sec...
August 22, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27500235/the-role-of-lysophosphatidic-acid-on-airway-epithelial-cell-denudation-in-a-murine-heterotopic-tracheal-transplant-model
#14
Yukiko Tando, Chiharu Ota, Mitsuhiro Yamada, Satoshi Kamata, Mutsuo Yamaya, Kuniyuki Kano, Shinichi Okudaira, Junken Aoki, Hiroshi Kubo
BACKGROUND: Chronic rejection is the major leading cause of morbidity and mortality after lung transplantation. Obliterative bronchiolitis (OB), a fibroproliferative disorder of the small airways, is the main manifestation of chronic lung allograft rejection. However, there is currently no treatment for the disease. We hypothesized that lysophosphatidic acid (LPA) participates in the progression of OB. The aim of this study was to reveal the involvement of LPA on the lesion of OB. METHODS: Ki16198, an antagonist specifically for LPA1 and LPA3, was daily administered into the heterotopic tracheal transplant model mice at the day of transplantation...
October 2015: Transplantation Direct
https://www.readbyqxmd.com/read/27496473/factors-affecting-breathing-capacity-and-early-tracheal-extubation-after-liver-transplantation-analysis-of-506-cases
#15
B Błaszczyk, B Wrońska, M Klukowski, E Flakiewicz, M Kołacz, L Jureczko, M Pacholczyk, A Chmura, J Trzebicki
BACKGROUND: Early extubation is a standard procedure after liver transplantation (LT). METHODS: The preoperative and perioperative data of 506 adult patients undergoing LT from July 2000 to March 2015 were analyzed. The goal of this study was to determine preoperative and perioperative independent predictors of early tracheal extubation. RESULTS: Of the 506 study patients, 73.7% were extubated early after LT. Patients in this group exhibited better preoperative and perioperative outcomes...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27426083/stem-cells-and-lung-regeneration
#16
REVIEW
Mohammad K El-Badrawy, Nesrein M Shalabi, Mie A Mohamed, Amany Ragab, Heba Wagih Abdelwahab
Tissues such as the lung, liver, and pancreas that have a low steady-state cell turnover yet can respond robustly after injury to replace damaged cells. The airway epithelium is exposed to inhaled particles and pathogens that may lead to the development of a many infectious and inflammatory respiratory diseases. Lung transplantation is an accepted modality of treatment for end-stage lung diseases. Since the early 1990 s, more than 26,000 lung transplants have been performed at centers worldwide. However, the availability of donor tissues and organs is limited, which presents a serious limitation for widespread transplantation surgery...
May 30, 2016: International Journal of Stem Cells
https://www.readbyqxmd.com/read/27388852/imatinib-ameliorates-bronchiolitis-obliterans-via-inhibition-of-fibrocyte-migration-and-differentiation
#17
Satoshi Watanabe, Kazuo Kasahara, Yuko Waseda, Hazuki Takato, Shingo Nishikawa, Taro Yoneda, Johsuke Hara, Takashi Sone, Miki Abo, Hideharu Kimura, Shinji Nakao
BACKGROUND: Imatinib, a tyrosine kinase inhibitor, has been proposed as a potential anti-fibrotic agent for fibroproliferative diseases, including bronchiolitis obliterans (BO). However, the underlying anti-fibrotic mechanisms of the agent remain unclear. We evaluated whether bone (BM)-derived progenitor cells, fibrocytes, might be a target of imatinib in the attenuation of BO. METHODS: We used a murine BO model induced by heterotopic tracheal transplantation and assessed the origin of fibroblasts by using green fluorescent protein-BM chimeric mice...
June 3, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27347307/hmgb1-exacerbates-bronchiolitis-obliterans-syndrome-via-rage-nf-%C3%AE%C2%BAb-hpse-signaling-to-enhance-latent-tgf-%C3%AE-release-from-ecm
#18
Long He, Fei Sun, Yi Wang, Jianghui Zhu, Jing Fang, Shu Zhang, Qilin Yu, Quan Gong, Boxue Ren, Xudong Xiang, Zhishui Chen, Qin Ning, Jifa Hu, Ping Yang, Cong-Yi Wang
Bronchiolitis obliterans syndrome (BOS), characterized by progressive airflow obstruction, is the main barrier to long-term graft survival after lung transplantation. Despite extensive studies, the mechanisms underlying BOS remain poorly understood, and targeted interventions have not yet been fully developed. In the present study, we employed a mouse model of tracheal transplantation and demonstrated that blockade of HMGB1 alone or combined with heparanase (HPSE) attenuates the development of BOS. It was noted that HMGB1 was first passively released from necrotic/damaged cells as a result of early unavoidable allograft injuries, leading to macrophage infiltration along with HMGB1 active secretion...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27284351/effects-of-bone-marrow-derived-mesenchymal-stem-cells-on-the-autophagic-activity-of-alveolar-macrophages-in-a-rat-model-of-silicosis
#19
Hui-Xing Zhu, Jun-Ling Gao, Man-Man Zhao, Ran Li, Yan-Xia Tian, Xin Wang, Juan Zhang, Ju-Xiang Yuan, Jian-Zhong Cui
The aim of the present study was to evaluate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) on the expression of the autophagy-associated proteins, microtubule-associated protein light chain 3 (LC-3) and autophagy-related gene Beclin-1 (Beclin-1), in alveolar macrophages (AMs) in a rat model of silicosis. Furthermore, the study investigated the molecular mechanisms underlying the effects of BMSC treatment. A population of 60 adult female Sprague-Dawley (SD) rats were allocated at random into three groups, namely the control, model and BMSC treatment groups (n=20 per group)...
June 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27260610/post-transplant-lymphoproliferative-disorder-of-the-pediatric-airway-presentation-and-management
#20
REVIEW
Allison F O'Neill, Eelam A Adil, Alexandria L Irace, Laura Neff, Ian J Davis, Antonio R Perez-Atayde, Stephan D Voss, Olga Weinberg, Reza Rahbar
OBJECTIVE: Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of immunosuppression with little consensus on its evaluation and management. The purpose of this contemporary review is to describe a pediatric patient with PTLD of the airway and review the literature to provide multidisciplinary recommendations regarding management. DATA SOURCES: Retrospective chart and literature review. REVIEW METHODS: A pediatric patient with PTLD of the airway is described...
July 2016: International Journal of Pediatric Otorhinolaryngology
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