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https://www.readbyqxmd.com/read/29351055/are-pre-terms-born-timely-and-right-immunized-results-of-an-italian-cohort-study
#1
Nicola Laforgia, Antonio Di Mauro, Francesco Paolo Bianchi, Federica Di Mauro, Andrea Zizzi, Manuela Capozza, Silvia Intini, Maria Serena Gallone, Silvio Tafuri
The aim of this study is to evaluate the vaccination coverage at 24 months of chronological age in a sample of preterm infants discharged by the Neonatal Intensive Care Unit (NICU) of the Bari Policlinico University General Hospital in Italy. The list of infants preterm born discharged during 2013 by the NICU was obtained by hospital database. Vaccination status of each subject at 24 months of chronological age was acquired by the Apulian Regional Vaccination Register (GIAVA). 159 preterm borns were enrolled in this study...
January 19, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29350334/the-triglyceride-glucose-index-an-insulin-resistance-marker-in-newborns
#2
Eva Gesteiro, Sara Bastida, Laura Barrios, Francisco J Sánchez-Muniz
The study aims to assess the utility of the triglyceride-glucose index (TyG) as a marker of insulin resistance (IR) in neonates. TyG and the homeostatic model assessment (HOMA-IR) values were compared in 196 singleton, term normoweight and without distress newborns. A Decision Tree procedure (CHAID) was used to classify cases into groups or predict values of a dependent (Ln HOMA-IR) variable. Three nodes were drawn for TyG: ≤ 6.7, > 6.7-7.8 and > 7.8 (p < 0.0001; F = 20.52). The predictability of those TyG values vs HOMA-IR was statistically significant (p < 0...
January 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29348260/the-canadian-preterm-birth-network-a-study-protocol-for-improving-outcomes-for-preterm-infants-and-their-families
#3
Prakesh S Shah, Sarah D McDonald, Jon Barrett, Anne Synnes, Kate Robson, Jonathan Foster, Jean-Charles Pasquier, K S Joseph, Bruno Piedboeuf, Thierry Lacaze-Masmonteil, Karel O'Brien, Sandesh Shivananda, Nils Chaillet, Petros Pechlivanoglou
BACKGROUND: Preterm birth (birth before 37 wk of gestation) occurs in about 8% of pregnancies in Canada and is associated with high mortality and morbidity rates that substantially affect infants, their families and the health care system. Our overall goal is to create a transdisciplinary platform, the Canadian Preterm Birth Network (CPTBN), where investigators, stakeholders and families will work together to improve childhood outcomes of preterm neonates. METHODS: Our national cohort will include 24 maternal-fetal/obstetrical units, 31 neonatal intensive care units and 26 neonatal follow-up programs across Canada with planned linkages to provincial health information systems...
January 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29346141/caffeine-controversies
#4
Samuel J Gentle, Colm P Travers, Waldemar A Carlo
PURPOSE OF REVIEW: Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction. The purpose of the review is to analyze this dynamic trajectory and discuss controversies that still remain after decades of caffeine use. RECENT FINDINGS: Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29345153/selective-serotonin-reuptake-inhibitor-use-in-pregnant-women-pharmacogenetics-drug-drug-interactions-and-adverse-effects
#5
Asher Ornoy, Gideon Koren
Possible negative effects of selective serotonin reuptake inhibitors (SSRIs) in pregnancy relate to congenital anomalies, negative perinatal events and neurodevelopmental outcome. Many studies are confounded by the underlying maternal disease and by pharmacogenetic and pharmacokinetic differences of these drugs. Areas covered: The possible interactions of SSRIs and serotonin and norepinephrine reuptake inhibitors with other drugs and the known effects of SSRIs on congenital anomalies, perinatal and neurodevelopmental outcome...
January 18, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29345007/aetiology-of-neonatal-conjunctivitis-evaluated-in-a-population-based-setting
#6
Minna Honkila, Marjo Renko, Irma Ikäheimo, Tytti Pokka, Matti Uhari, Terhi Tapiainen
AIM: Our aim was to study prospectively the aetiology of neonatal conjunctivitis in a population-based setting. METHODS: Altogether 173 neonates with clinical conjunctivitis aged on average 20 (SD 10) days were recruited from child welfare clinics in Oulu, Finland, in 2010-2015. Conjunctival specimens were collected from 167 neonates for multiplex polymerase chain reaction to detect 16 respiratory viruses, from 163 for polymerase chain reaction to detect Chlamydia trachomatis and Neisseria gonorrhoeae and from 160 for bacterial culture studies...
January 18, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29343190/factors-affecting-effective-ventilation-during-newborn-resuscitation-a-qualitative-study-among-midwives-in-rural-tanzania
#7
R Moshiro, H L Ersdal, P Mdoe, H L Kidanto, C Mbekenga
BACKGROUND: Intrapartum-related hypoxia accounts for 30% of neonatal deaths in Tanzania. This has led to the introduction and scaling-up of the Helping Babies Breathe (HBB) programme, which is a simulation-based learning programme in newborn resuscitation skills. Studies have documented ineffective ventilation of non-breathing newborns and the inability to follow the HBB algorithm among providers. OBJECTIVE: This study aimed at exploring barriers and facilitators to effective bag mask ventilation, an essential component of the HBB algorithm, during actual newborn resuscitation in rural Tanzania...
2018: Global Health Action
https://www.readbyqxmd.com/read/29338857/obstetric-complications-after-frozen-versus-fresh-embryo-transfer-in-women-with-polycystic-ovary-syndrome-results-from-a-randomized-trial
#8
Bo Zhang, Daimin Wei, Richard S Legro, Yuhua Shi, Jing Li, Lin Zhang, Yan Hong, Gang Sun, Ting Zhang, Weiping Li, Zi-Jiang Chen
OBJECTIVE: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). DESIGN: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). SETTING: Reproductive medicine centers. PATIENT(S): A total of 1,508 patients with a diagnosis of PCOS who were undergoing IVF were enrolled...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338783/children-with-premature-pubarche-is-an-alterated-neonatal-17-ohp-screening-test-a-predictive-factor
#9
Paolo Cavarzere, Margherita Mauro, Monica Vincenzi, Silvana Lauriola, Francesca Teofoli, Rossella Gaudino, Diego Alberto Ramaroli, Rocco Micciolo, Marta Camilot, Franco Antoniazzi
BACKGROUND: Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screening might later develop signs of androgen excess. The aim of this study is to verify whether a slightly elevated 17-OHP at newborn screening is a predictive factor for premature pubarche. METHODS: We evaluated all infants born between 2001 and 2014 with premature pubarche...
January 16, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29338079/nutrition-delivery-and-growth-outcomes-in-infants-with-gastroschisis
#10
Charles R Hong, David Zurakowski, Brenna S Fullerton, Katelyn Ariagno, Tom Jaksic, Nilesh M Mehta
BACKGROUND: We aimed to describe nutrient intake and growth in infants with gastroschisis and identify factors associated with impaired growth. METHODS: Retrospective study of neonates who underwent gastroschisis repair from 2010 to 2015. Nutrient intake and weight-for-age z scores (WAZ) were recorded. RESULTS: Data from 60 eligible infants with median (Q1, Q3) gestational age of 36 weeks (35, 37) and birth weight 2418 g (2098, 2665) were analyzed...
January 8, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29336466/magnolol-protects-against-ischemic-reperfusion-brain-damage-following-oxygen-glucose-deprivation-and-transient-focal-cerebral-ischemia
#11
Sheng-Yang Huang, Shih-Huang Tai, Che-Chao Chang, Yi-Fang Tu, Chih-Han Chang, E-Jian Lee
In the present study, the neuroprotective potential of magnolol against ischemia-reperfusion brain injury was examined via in vivo and in vitro experiments. Magnolol exhibited strong radical scavenging and antioxidant activity, and significantly inhibited the production of interleukin‑6, tumor necrosis factor‑a and nitrite/nitrate (NOX) in lipopolysaccharide-stimulated BV2 and RAW 264.7 cells when applied at concentrations of 10 and 50 µM, respectively. Magnolol (100 µM) also significantly attenuated oxygen‑glucose deprivation‑induced damage in neonatal rat hippocampal slice cultures, when administered up to 4 h following the insult...
January 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29335026/congenital-anomalies-in-neurofibromatosis-1-a-retrospective-register-based-total-population-study
#12
Jussi Leppävirta, Roope A Kallionpää, Elina Uusitalo, Tero Vahlberg, Minna Pöyhönen, Juha Peltonen, Sirkku Peltonen
BACKGROUND: Neurofibromatosis type 1 (NF1) is a dominantly inherited Rasopathy caused by mutations in the NF1 gene on chromosome 17. NF1 has been connected to congenital anomalies, e.g., in the skeletal and cardiovascular systems, but the overall incidence of anomalies is unknown. In this retrospective register-based total population study conducted in Finland, the congenital anomalies in NF1 were evaluated. METHODS: One thousand four hundred ten patients with NF1 were identified by searching the medical records related to inpatient and outpatient hospital visits of patients with an associated diagnosis for NF1 in 1987-2011...
January 15, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29335023/early-neonatal-glutaric-aciduria-type-i-hidden-by-perinatal-asphyxia-a-case-report
#13
Giacomo Biasucci, Nicola Morelli, Federica Natacci, Massimo Mastrangelo
BACKGROUND: Perinatal asphyxia (PA) occurs in about 2 to 10 per 1000 live full-term births. Although neonatal epileptic seizures are observed in up to 60% of cases, PA may mimic or subtend other conditions. Hypoxia related brain injury is particularly relevant, as it may have permanent effects on neuropsychomotor development. Antepartum obstetric conditions, may, in turn, lead to hypoxic-ischemic damage to the fetus and the newborn, often underlying PA. Herein, a case of PA that hid and triggered signs and symptoms of Glutaric Aciduria type I (GA-I), is reported...
January 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29334920/factors-influencing-access-of-pregnant-women-and-their-infants-to-their-local-healthcare-system-a-prospective-multi-centre-observational-study
#14
Shabir A Madhi, Luis M Rivera, Xavier Sáez-Llorens, Clara Menéndez, Nazira Carrim-Ganey, Mark F Cotton, Darren Katzman, Mariëtha M Luttig, Rosalba Candelario, Sherryl Baker, Mahua Roychoudhury
BACKGROUND: The successful implementation of maternal vaccination relies on results of clinical trials, considering the prenatal and postnatal attendance at selected healthcare institutions. This study evaluated factors influencing maternal/infant access to healthcare facilities to identify potential barriers to participation in future clinical trials on maternal vaccination. METHODS: In this prospective, multi-centre, observational study, pregnant women (N = 3243) were enrolled at ten sites across Panama, the Dominican Republic, South Africa, and Mozambique between 2012 and 2014...
January 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29334142/severe-ectropion-in-lamellar-ichthyosis-managed-medically-with-oral-acitretin
#15
Manpreet Singh, Manpreet Kaur, Ripanjeet Kaur, Shakeen Singh
Congenital ectropion is commonly associated with lamellar ichthyosis. Severe eyelid ectropion may cause corneal exposure, keratopathy, and permanent corneal scarring. We report a neonate with severe, bilateral, congenital ectropion and eclabium managed using oral retinoids. Both corneas were protected with topical antibiotics and lubricating eyedrops and eye ointments. At 12-month follow-up, the child was doing well, with no ectropion or corneal opacity.
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29331747/dural-based-cavernous-malformation-at-the-cerebral-convexity-report-of-two-pediatric-patients
#16
Guichen Li, Xuan Zhai, Yang Zhang, Ping Liang, Xuanxuan Wu, Kun Hou
BACKGROUND: Intracranial (cavernous malformations) CMs are usually located at the cerebral parenchyma, dural-based CMs outside the middle fossa are rarely reported. To our knowledge, dural-based CMs located at the cerebral convexity are even rarer that only two pediatric cases were ever reported. In this report, we present two extremely rare cases of dural-based CMs at the cerebral convexity in pediatric patients. The clinical course, radiological and pathological features, treatment, and follow-up are described...
January 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29328035/assessment-of-neurodevelopmental-outcomes-in-infants-6-12-months-of-age-according-to-impact-of-perinatal-risk-factors
#17
N Tskimanauri, N Khachapuridze, P Imnadze, T Chanadiri, S Bakhtadze
The purpose of this research was to investigate the developmental follow-up of infants (at age of 6 month and 12 month), exposed to separate and combination impact of perinatal risk factors, compared with not exposed cases, within the prospective cohort study. Between January 2015 and January 2017, in this research we prospectively enrolled 1018 live-born infants from the medical reports of the participating clinics in Tbilisi (capital of Republic of Georgia) and Mtskheta, Dusheti (districts of Georgia). Within postnatal follow-up, the children from whole population were assessed at 6 and 12 months of age by family doctors using the Denver Developmental Screening Test (Denver II)...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29326372/caecal-duplication-cyst-a-rare-cause-of-neonatal-intestinal-obstruction
#18
Hicham Abdellaoui, Abdelhalim Mahmoudi, Mohammed Tazi Charki, Youssef Bouabdallah
We report a rare case of duplication cyst of the caecum responsible for an intestinal obstruction in a 5-day-old newborn. Preoperatively, we suspected the diagnosis of enteric duplication as ultrasonography demonstrated a cystic mass in the right iliac fossa, and laparotomy confirmed an obstructive caecal mass which was resected and an end-to-end anastomosis was performed. The neonate completely recovered with an uneventful follow-up.
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29326055/a-retrospective-biochemical-molecular-and-neurocognitive-review-of-saudi-patients-with-argininosuccinic-aciduria
#19
Ruqaiah AlTassan, Dalal Bubshait, Faiqa Imtiaz, Zuhair Rahbeeni
A retrospective review was compiled of 54 patients with argininosuccinic aciduria who were either identified through the Saudi National Newborn Screening Program or diagnosed clinically from January 2000 to December 2015. The duration of follow-up is from 2 to 19 years. The majority of patients (65%) originated from the central province of Saudi Arabia. The mean patient age at review was 10 years (2-19 years), 92% received an early diagnosis (<28 days of age) and most were symptomatic at the time of the diagnosis (n = 34)...
January 8, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29326011/neonatal-intestinal-colonization-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-a-five-year-follow-up-study
#20
V Nordberg, K Jonsson, C G Giske, A Iversen, O Aspevall, B Jonsson, A Camporeale, M Norman, L Navér
OBJECTIVE: To analyse Klebsiella pneumoniae (KP) isolates from an outbreak of Extended-Spectrum β-Lactamase (ESBL)-producing KP and Escherichia coli (ESBL-EC) among infants admitted to neonatal intensive care units (NICUs) and to determine the duration of the intestinal colonization. METHODS: A prospective cohort study of intestinal ESBL-KP/ ESBL-EC colonized neonates after a five-month outbreak in two NICUs. Whole genome sequencing (WGS), multilocus sequence typing (MLST), core genome MLST, pulsed-field electrophoresis (PFGE) and PCR for blaCTX-M were performed on the first isolates...
January 8, 2018: Clinical Microbiology and Infection
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