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Developmental Outcome

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https://www.readbyqxmd.com/read/28223922/gut-microbiota-a-potential-regulator-of-neurodevelopment
#1
REVIEW
Paola Tognini
During childhood, our brain is exposed to a variety of environmental inputs that can sculpt synaptic connections and neuronal circuits, with subsequent influence on behavior and learning processes. Critical periods of neurodevelopment are windows of opportunity in which the neuronal circuits are extremely plastic and can be easily subjected to remodeling in response to experience. However, the brain is also more susceptible to aberrant stimuli that might lead to altered developmental trajectories. Intriguingly, postnatal brain development is paralleled by the maturation of the gut microbiota: the ecosystem of symbionts populating our gastro-intestinal tract...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28222640/dynamic-long-leg-casting-fixation-for-treating-12-to-18-month-old-infants-with-developmental-dysplasia-of-the-hip
#2
Zhencun Cai, Lianyong Li, Lijun Zhang, Shijun Ji, Qun Zhao
Objective To evaluate the effect of dynamic long leg casting in paediatric patients with developmental dysplasia of hip (DDH) diagnosed at 12-18 months. Methods The adductor tenotomy, closed reduction, and dynamic long leg casting method was adopted to treat paediatric patients with DDH. The hips were divided into four groups according to the Tonnis radiographic dislocation classification. Groups were also classified according to the baseline acetabular index (AI): 30°-35°, 36°-40°, and > 40°. The outcomes of the reductions were evaluated according to McKay's hip function criteria and Severin's radiological criteria...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28222133/maternal-psychological-stress-induced-developmental-disability-neonatal-mortality-and-stillbirth-in-the-offspring-of-wistar-albino-rats
#3
Sakthivel Govindaraj, Annadurai Shanmuganathan, Ravindran Rajan
BACKGROUND: Stress is an inevitable part of life, and maternal stress during the gestational period has dramatic effects in the early programming of the physiology and behavior of offspring. The developmental period is crucial for the well-being of the offspring. Prenatal stress influences the developmental outcomes of the fetus, in part because the developing brain is particularly vulnerable to stress. The etiology of birth defects of the offspring is reported to be 30-40% genetic and 7-10% multifactorial, with the remaining 50% still unknown and also there is no clear cause for neonatal mortality and still-birth...
2017: PloS One
https://www.readbyqxmd.com/read/28220955/profiles-of-adolescent-religiousness-using-latent-profile-analysis-implications-for-psychopathology
#4
Gregory S Longo, Bethany C Bray, Jungmeen Kim-Spoon
Prior research has documented robust associations between adolescent religiousness/spirituality (R/S) and psychopathology outcomes including externalizing and internalizing symptomatology, yet no previous studies have examined these associations with adolescent R/S profiles using a person-centred approach. We examined whether there are identifiable subgroups characterized by unique multidimensional patterns of R/S experiences and how these experiences may be related to externalizing and internalizing symptomatology...
March 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28220490/biological-embedding-of-perinatal-social-relationships-in-infant-stress-reactivity
#5
Jenna C Thomas, Nicole Letourneau, Crystal I Bryce, Tavis S Campbell, Gerald F Giesbrecht
Whereas significant advances have been made in understanding how exposure to early adversity "gets under the skin" of children to result in long term changes in developmental outcomes, the processes by which positive social relationships become biologically embedded remain poorly understood. The aim of this study was to understand the pathways by which maternal and infant social environments become biologically embedded in infant cortisol reactivity. Two hundred seventy-two pregnant women and their infants were prospectively assessed during pregnancy and at 6 months postpartum...
February 21, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28220477/parent-child-learning-interactions-a-review-of-the-literature-on-scaffolding
#6
Roni Mermelshtine
BACKGROUND: Scaffolding can be observed during learning-based interactions, when interventions by parents are adjusted according to children's observed abilities, with the main goal of enabling the child to work independently (Wood et al., 1976, Journal of child psychology and psychiatry, 17, 89). Such contingent instruction behaviours occur from infancy, and are said to be relevant for children's development of executive function, language acquisition, and cognitive and academic abilities...
February 21, 2017: British Journal of Educational Psychology
https://www.readbyqxmd.com/read/28220358/potential-risk-factors-for-the-development-of-self-injurious-behavior-among-infants-at-risk-for-autism-spectrum-disorder
#7
Adele F Dimian, Kelly N Botteron, Stephen R Dager, Jed T Elison, Annette M Estes, John R Pruett, Robert T Schultz, Lonnie Zwaigenbaum, Joseph Piven, Jason J Wolff
Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose of this study was to evaluate behavioral characteristics predicting SIB at age 2 years among 235 infants at high familial risk for ASD. Logistic regression results indicated that presence of SIB or proto-SIB and lower developmental functioning at age 12 months significantly predicted SIB at 24 months...
February 20, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28219764/gabaa-receptor-expression-and-white-matter-disruption-in-intrauterine-growth-restricted-piglets
#8
Viskasari P Kalanjati, Julie A Wixey, Stephanie M Miller, Paul B Colditz, Stella T Bjorkman
Intrauterine growth restriction (IUGR) is one of the most common causes of perinatal mortality and morbidity. White matter and neuronal injury are major pathophysiological features of the IUGR neonatal brain. GABAA (γ-aminobutyric acid type A) receptors have been shown to play a role in oligodendrocyte differentiation and proliferation in the neonatal brain and may be a key factor in white matter injury and myelination in IUGR neonates. Whether there are impairments to the GABAergic system and neuronal cytoskeleton in IUGR brain has yet to be elucidated...
February 17, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28216563/the-genomic-impact-of-dna-cpg-methylation-on-gene-expression-relationships-in-prostate-cancer
#9
REVIEW
Mark D Long, Dominic J Smiraglia, Moray J Campbell
The process of DNA CpG methylation has been extensively investigated for over 50 years and revealed associations between changing methylation status of CpG islands and gene expression. As a result, DNA CpG methylation is implicated in the control of gene expression in developmental and homeostasis processes, as well as being a cancer-driver mechanism. The development of genome-wide technologies and sophisticated statistical analytical approaches has ushered in an era of widespread analyses, for example in the cancer arena, of the relationships between altered DNA CpG methylation, gene expression, and tumor status...
February 14, 2017: Biomolecules
https://www.readbyqxmd.com/read/28216171/toward-a-unified-theory-of-childhood-trauma-and-psychosis-a-comprehensive-review-of-epidemiological-clinical-neuropsychological-and-biological-findings
#10
REVIEW
Błażej Misiak, Maja Krefft, Tomasz Bielawski, Ahmed A Moustafa, Maria M Sąsiadek, Dorota Frydecka
There is a growing body of research focused on the relationship between childhood trauma and the risk of developing psychosis. Numerous studies, including many large-scale population-based studies controlling for possible mediating variables, provide persuasive evidence of a dose-response association and are indicative of a causal relationship. Existing evidence supports the specificity model, showing differential associations between particular adversities and clinical symptoms, with cumulative adversity causing less favorable clinical and functional outcomes in psychotic patients...
February 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28214726/job-satisfaction-developmental-trajectories-and-health-a-life-course-perspective
#11
Jonathan Dirlam, Hui Zheng
Understanding the health consequence of job dissatisfaction becomes increasingly important because job insecurity, stress and dissatisfaction have significantly increased in the United States in the last decade. Despite the extensive work in this area, prior studies nonetheless may underestimate the harmful effect of job dissatisfaction due to the cross-sectional nature of their data and sample selection bias. This study applies a life-course approach to more comprehensively examine the relationship between job satisfaction and health...
January 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28214165/agenesis-of-the-corpus-callosum-and-aicardi-syndrome-a%C3%A2-neuroimaging-and-clinical-comparison
#12
T Govil-Dalela, A Kumar, R Agarwal, H T Chugani
BACKGROUND: Agenesis of the corpus callosum can occur in individuals with epilepsy, either in isolation or as part of various neurological conditions, such as Aicardi syndrome. In this study, we evaluated the clinical and neuroradiological differences between children with nonsyndromic agenesis of the corpus callosum and those with Aicardi syndrome. METHODS: We evaluated 31 children with epilepsy and agenesis of the corpus callosum (11 males, 20 females), 14 of whom had Aicardi syndrome (all females)...
January 4, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28212519/early-calibration-of-the-hpa-axis-by-maternal-psychopathology
#13
Heidemarie Laurent
Given the central role of stress-responsive neurophysiology in mental and physical health, it is important to understand how particular patterns of stress responsivity may become entrained by the early caregiving environment. In this study we investigated links between maternal depression and anxiety symptom profiles and within-infant development of hypothalamic-pituitary-adrenal (HPA) axis responses from 6 to 18 months of life. Associations with infant cognitive and social-emotional development were also tested to gauge the adjustment implications of HPA response trajectories...
February 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28211648/cognitive-development-in-preterm-infants-multi-faceted-deficits-reflect-vulnerability-of-rigorous-neurodevelopmental-pathways
#14
Jessie R Maxwell, Tracylyn R Yellowhair, Akosua Y Oppong, Jenny E Camacho, Jean R Lowe, Lauren L Jantzie, Robin K Ohls
Prematurity remains the major cause of neonatal morbidity and mortality, with 15 million preterm births occurring worldwide in 2010. Infants born less than 37 weeks gestation are at high risk of abnormal neurodevelopmental outcomes, given that the central nervous system is extremely sensitive to an abnormal intra- and extra-uterine environment. Children born preterm have multiple neurodevelopmental sequelae involving dynamic and complex cognitive deficits. Former preterm infants have difficulty with each domain of cognition, including executive function, language, learning and memory, complex attention, perceptual-motor function and social cognition when compared to children born at term...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28210520/synchronous-aberrant-cerebellar-and-opercular-development-in-fetuses-and-neonates-with-congenital-heart-disease-correlation-with-early-communicative-neurodevelopmental-outcomes-initial-experience
#15
A Wong, T Chavez, S O'Neil, J Votava-Smith, D Miller, S delCastillo, A Panigrahy, L Paquette
Patients with congenital heart disease (CHD) demonstrate multidomain cognitive delays. Cingulo-opercular and cerebellar brain networks are critical to language functions. This is a description of our initial experience aiming to identify an anatomic correlate for CHD patients with expressive language delays. Fetal CHD patients, prospectively enrolled, underwent serial fetal (1.5T), postnatal pre- and postoperative (3T) MRI. Non-CHD patients were enrolled retrospectively from the same epoch. Comparable fetal and neonatal T2 contrast was used for manual linear cross-sectional measurement...
January 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28207685/trends-in-postpartum-depressive-symptoms-27-states-2004-2008-and-2012
#16
Jean Y Ko, Karilynn M Rockhill, Van T Tong, Brian Morrow, Sherry L Farr
Postpartum depression is common and associated with adverse infant and maternal outcomes (e.g., lower breastfeeding initiation and duration and poor maternal and infant bonding) (1-3). A developmental Healthy People 2020 objective is to decrease the proportion of women delivering a live birth who experience postpartum depressive symptoms (PDS).* To provide a baseline for this objective, CDC sought to describe self-reported PDS overall, by reporting state, and by selected sociodemographic factors, using 2004, 2008, and 2012 data from the Pregnancy Risk Assessment Monitoring System (PRAMS)...
February 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28205734/p-32-the-development-of-a-multidisciplinary-team-to-evaluate-early-developmental-outcomes-of-infants-with-tof-oa
#17
K Walker, J Karpelowsky, D Fitzgerald, A Loughran-Fowlds, N Badawi
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28204923/language-deprivation-syndrome-a-possible-neurodevelopmental-disorder-with-sociocultural-origins
#18
Wyatte C Hall, Leonard L Levin, Melissa L Anderson
PURPOSE: There is a need to better understand the epidemiological relationship between language development and psychiatric symptomatology. Language development can be particularly impacted by social factors-as seen in the developmental choices made for deaf children, which can create language deprivation. A possible mental health syndrome may be present in deaf patients with severe language deprivation. METHODS: Electronic databases were searched to identify publications focusing on language development and mental health in the deaf population...
February 16, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28202597/histone-lysine-to-methionine-mutations-reduce-histone-methylation-and-cause-developmental-pleiotropy
#19
Dean Sanders, Shuiming Qian, Rachael Fieweger, Li Lu, James A Dowell, John M Denu, Xuehua Zhong
Epigenetic modifications play critical roles in diverse biological processes. Histone lysine to methionine (K-to-M) mutations act as gain-of-function mutations to inhibit a wide range of histone methyltransferases and are thought to promote tumorigenesis. However, it is largely unknown whether K-to-M mutations impact development at the whole organismal level. Using Arabidopsis as a model system, we discovered that a transgene exogenously expressing histone 3 lysine 36 to methionine mutation (K36M) acts in a dominant negative manner to cause global reduction of H3K36 methylation...
February 15, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28202109/-early-intellectual-developmental-outcome-of-late-preterm-infants
#20
Teng-Wei Zhang, Fa-Tao Lin, Yan-Yan Song, Lan-Xiu Wang, Yue-Ju Cai
OBJECTIVE: To investigate the early intellectual developmental outcome of late preterm infants. METHODS: A total of 106 late preterm infants with a gestational age of 34-36(+6) weeks who were admitted to the neonatal ward between January 2012 and January 2015, cured, discharged, and regularly followed up at the outpatient service for high-risk children were enrolled as the preterm group. A total of 120 healthy full-term infants during the same period were randomly selected as the term group...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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