Qing Zhong, Hua-Gen Wang, Ji-Hong Yang, Ru-Hong Tu, An-Yao Li, Gui-Rong Zeng, Qiao-Ling Zheng, Zhi- Yu Liu, Zhi-Xin Shang-Guan, Xiao- Bo Huang, Qiang Huang, Yi-Fan Li, Hua-Long Zheng, Guang-Tan Lin, Ze-Ning Huang, Kai-Xiang Xu, Wen-Wu Qiu, Mei-Chen Jiang, Ya-Jun Zhao, Jian-Xian Lin, Zhi-Hong Huang, Jing-Min Huang, Ping Li, Jian-Wei Xie, Chao-Hui Zheng, Qi-Yue Chen, Chang-Ming Huang
Gastric cancer stem cells (GCSCs) are self-renewing tumor cells that govern chemoresistance in gastric adenocarcinoma (GAC), whereas their regulatory mechanisms remain elusive. Here, the study aims to elucidate the role of ATOH1 in the maintenance of GCSCs. The preclinical model and GAC sample analysis indicate that ATOH1 deficiency is correlated with poor GAC prognosis and chemoresistance. ScRNA-seq reveals that ATOH1 is downregulated in the pit cells of GAC compared with those in paracarcinoma samples. Lineage tracing reveals that Atoh1 deletion strongly confers pit cell stemness...
November 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)