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Polymyxins

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https://www.readbyqxmd.com/read/29348804/lysine-analogue-of-polymyxin-b-as-a-significant-opportunity-for-photodynamic-antimicrobial-chemotherapy
#1
Florent Le Guern, Tan-Sothea Ouk, Catherine Ouk, Regis Vanderesse, Yves Champavier, Emilie Pinault, Vincent Sol
In order to highlight the potential of photodynamic antimicrobial chemotherapy in case of infections by antibiotic resistant-strains, a new antimicrobial peptide conjugate has been synthesized, consisting of a derivative of polymyxin B and a cationic porphyrin covalently attached together to a spacer. A polymyxin-derived moiety was subjected to a primary structural modification in the replacement of four diaminobutyrate residues with lysine ones. This modification was done in order to strongly reduce bactericidal activity, with the aim to eliminate the potential rise of polymyxin-resistant strains...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29340720/correction-to-polymyxin-b-immobilized-hemoperfusion-and-mortality-in-critically-ill-adult-patients-with-sepsis-septic-shock-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#2
Tomoko Fujii, Riki Ganeko, Yuki Kataoka, Toshi A Furukawa, Robin Featherstone, Kent Doi, Jean-Louis Vincent, Daniela Pasero, René Robert, Claudio Ronco, Sean M Bagshaw
Owing to an oversight by the authors, Figure 2 in this article was not the version intended for publication. The correct Figure 2, reproduced here, features footnote symbols and Figure 2b includes three studies as described in the main text.
January 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29340452/detection-of-multidrug-resistant-pseudomonas-aeruginosa-harboring-bla-ges-1-and-bla-ges-11-in-recife-brazil
#3
Valdemir Vicente da Silva Júnior, Laura Durão Ferreira, Lílian Rodrigues Alves, Adriane Borges Cabral, Paula Regina Luna de Araújo Jácome, Paulo Sérgio Ramos de Araújo, Ana Catarina de Souza Lopes, Maria Amélia Vieira Maciel
INTRODUCTION: Pseudomonas aeruginosa, an important pathogen globally, presents several resistance mechanisms. This study aimed to investigate the presence of bla GES in clinical isolates of Pseudomonas aeruginosa obtained from various clinical specimens from patients admitted to three different hospitals in Recife, Brazil. The Guiana extended spectrum beta-lactamase (GES) enzymes are responsible for conferring broad spectrum resistance to beta-lactam drugs, including the carbapenems. METHODS: A total of 100 carbapenem-resistant P...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29339386/pterostilbene-a-potential-mcr-1-inhibitor-that-enhances-the-efficacy-of-polymyxin-b
#4
Yonglin Zhou, Shui Liu, Tingting Wang, Hui Li, Shusheng Tang, Jianfeng Wang, Yang Wang, Xuming Deng
We characterized pterostilbene produced a synergistic effect with polymyxin B (FIC index=0.156 or 0.188) against MCR-producing Escherichia coli strains of both human and animal origin. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate a mcr-1- and NDM-positive E. coli strain ZJ487, but the combination eliminated by 1-hour post-inoculation. The survival rate of mouse following the intraperitoneal infection significantly promoted from 0% to 60% in the group of combination therapy applied...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29329393/tgf-%C3%AE-mediated-nadph-oxidase-4-dependent-oxidative-stress-promotes-colistin-induced-acute-kidney-injury
#5
Bo Young Jeong, Se-Ra Park, Sungkwon Cho, Seong-Lan Yu, Hoi Young Lee, Chang Gyo Park, Jaeku Kang, Da-Young Jung, Moon Hyang Park, Won-Min Hwang, Sung-Ro Yun, Ju-Young Jung, Se-Hee Yoon
Background: Colistin (polymyxin E) is an important constituent of the polymyxin class of cationic polypeptide antibiotics. Intrarenal oxidative stress can contribute to colistin-induced nephrotoxicity. Nicotinamide adenine dinucleotide 3-phosphate oxidases (Noxs) are important sources of reactive oxygen species. Among the various types of Noxs, Nox4 is predominantly expressed in the kidney. Objectives: We investigated the role of Nox4 and benefit of Nox4 inhibition in colistin-induced acute kidney injury using in vivo and in vitro models...
January 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29319510/metallo-beta-lactamase-producing-pseudomonas-aeruginosa-in-a-healthcare-setting-in-alexandria-egypt
#6
Amani F Abaza, Soraya A El Shazly, Heba S A Selim, Gehan S A Aly
Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of metallo-beta-lactamase (MBL) producing P. aeruginosa in a healthcare setting in Alexandria, Egypt. This cross sectional study included 1583 clinical samples that were collected from patients admitted to Alexandria University Students' Hospital. P. aeruginosa isolates were identified using standard microbiological methods and were tested for their antimicrobial susceptibility patterns using single disc diffusion method according to the Clinical and Laboratory Standards Institute recommendations...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29319449/management-and-closure-of-multiple-large-cutaneous-lesions-in-a-juvenile-cat-with-severe-acquired-skin-fragility-syndrome-secondary-to-iatrogenic-hyperadrenocorticism
#7
C Noël McKnight, Linda J Lew, David A Gamble
CASE DESCRIPTION A 13-month-old castrated male cat was evaluated for a large, spontaneously developed cutaneous laceration over the left scapular region. The cat had a history of severe gingivostomatitis, conjunctivitis, giardiasis, and feline herpesvirus infection and had received systemic glucocorticoid treatment for 7 weeks prior to evaluation. CLINICAL FINDINGS Physical examination revealed a 10 × 7-cm full-thickness cutaneous laceration over the left scapular region, extremely thin skin, crusts over the dorsal aspect of the neck and base of the skull, medially curling pinnae, and moderate gingivostomatitis...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29315029/correlations-among-resistances-to-different-antimicrobial-compounds-in-salmonella-strains-from-hen-eggshells
#8
Maria Luisa Fernández Márquez, María José Grande Burgos, Rubén Pérez Pulido, Antonio Gálvez, Rosario Lucas López
Persistence of antibiotic-resistant Salmonella in the food chain may depend on strain tolerance to other antimicrobials and also on biofilm formation capacity. Yet, there is limited information on sensitivity of antibiotic-resistant Salmonella to other antimicrobials, such as phenolic compounds, chemical preservatives, or antimicrobial peptides. This study aimed at correlating antimicrobial resistance and biofilm formation capacity in antibiotic-resistant, biocide-tolerant Salmonella strains from hen eggshells...
February 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29311071/population-pharmacokinetics-of-polymyxin-b-in-acutely-ill-adult-patients
#9
Cristina Miglis, Nathaniel J Rhodes, Sean Avedissian, Christine J Kubin, Michael T Yin, Brian Nelson, Manjunath P Pai, Marc H Scheetz
Polymyxin B (PB) has reemerged as a common treatment against multidrug-resistant Gram-negative pathogens. However, nephrotoxicity remains a significant dose-limiting side effect and contemporary pharmacokinetic (PK) data is limited. This study sought to evaluate PB exposure differences in various load and non-loading strategies according to total body weight (TBW) and adjusted body weight (ABW). Patients treated with PB had plasma samples obtained for clinical care and analyzed using LC-MS/MS. Compartmental PK models with linear and allometric scaling of TBW were explored...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311066/population-pharmacokinetics-of-intravenous-polymyxin-b-from-clinical-samples
#10
Christine J Kubin, Brian C Nelson, Cristina Miglis, Marc H Scheetz, Nathaniel Rhodes, Sean Avedissian, Serge Cremers, Michael T Yin
A retrospective study was conducted in hospitalized patients receiving intravenous polymyxin B who underwent therapeutic drug monitoring during treatment. The aim of this study was to assess the population pharmacokinetics (PK) of intravenous polymyxin B in patients with variable total body weights and create a population model for clinical use. Nonlinear mixed-effects modeling analyses were performed. A total of 43 patients were included: 70% were male with a median age of 58 years and a median weight of 78 kg...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29305960/antibiotic-susceptibilities-of-livestock-isolates-of-leptospira
#11
Geoffroy Liegeon, Tristan Delory, Mathieu Picardeau
Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are regularly exposed to antibiotic treatments. In this study, we assess the susceptibility of 35 Leptospira strains isolated from food-producing animals of diverse geographical origins between 1936 and 2016 to the antimicrobial agents most commonly used in animals...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29305954/clinical-use-of-the-polymyxins-the-tale-of-the-fox-and-the-cat
#12
Eric Wenzler, Kristen L Bunnell, Larry H Danziger
BACKGROUND: There is a need to identify practice patterns of polymyxin use, quantify gaps in knowledge, and recognize areas of persistent confusion. METHODS: A structured electronic survey was distributed to physicians, pharmacists, and microbiologists. Demographic information was obtained along with data regarding the availability, stewardship principles, therapeutic usage, dosing, microbiological testing, and knowledge, attitudes, and beliefs regarding the polymyxins...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29301590/an-increase-in-the-prevalence-of-kpc-nosocomial-bacteremia-as-a-trigger-for-growing-polymyxin-resistance-among-other-multidrug-resistant-non-kpc-producing-enterobacteriaceae-isolates
#13
Leandro Reus Rodrigues Perez
No abstract text is available yet for this article.
January 5, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29290748/therapeutic-drug-monitoring-of-prolonged-infusion-aztreonam-for-multi-drug-resistant-pseudomonas-aeruginosa-a-case-report
#14
Jeffrey J Cies, Richard J LaCoursiere, Wayne S Moore, Arun Chopra
Aztreonam, a broad-spectrum monobactam, is typically reserved for multidrug resistant (MDR) infections. Pharmacokinetic (PK) data to guide dosing in children, however, are limited to healthy volunteers or nonintensive care unit (ICU) patients. Impaired antibiotic delivery into tissue remains a major concern and may explain the high morbidity and mortality associated with MDR infections. Therefore, evaluating the PK changes in pediatric ICU patients is necessary to elucidate the most appropriate antimicrobial regimen...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29288722/comparative-analysis-of-phosphoethanolamine-transferases-involved-in-polymyxin-resistance-across-ten-clinically-relevant-gram-negative-bacteria
#15
Jiayuan Huang, Yan Zhu, Meiling Han, Mengyao Li, Jiangning Song, Tony Velkov, Chen Li, Jian Li
The rapid emergence of Gram-negative 'superbugs' has become a significant threat to human health globally and polymyxins become a last-line therapy for these very problematic pathogens. Polymyxins exhibit their antibacterial killing by the initial interaction with lipid A in Gram-negative bacteria. Polymyxin resistance can be mediated by phosphoethanolamine (PEA) modification of lipid A that abolishes the initial electrostatic interaction with polymyxins. Both chromosome-encoded (e.g. EptA, EptB and EptC) and plasmid-encoded PEA transferases (e...
December 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29281684/candida-albicans-derived-mannoproteins-activate-nf-%C3%AE%C2%BAb-in-reporter-cells-expressing-tlr4-md2-and-cd14
#16
Traci Ness, Mahmud Abdallah, Jaime Adams, Claudia Alvarado, Edwin Gunn, Brittany House, John Lamb, Jack Macguire, Emily Norris, Rebekah Robinson, Morgan Sapp, Jill Sharma, Ronald Garner
The ability of soluble C. albicans 20A (serotype A) mannoprotein (CMP) to serve as a ligand for toll-like receptor 4 (TLR4) and its co-receptors was examined using commercially available and stably-transfected HEK293 cells that express human TLR4, MD2 and CD14, but not MR. These TLR4 reporter cells also express an NF-κB-dependent, secreted embryonic alkaline phosphatase (SEAP) reporter gene. TLR4-reporter cells exhibited a dose-dependent SEAP response to both LPS and CMP, wherein peak activation was achieved after stimulation with 40-50 μg/mL of CMP...
2017: PloS One
https://www.readbyqxmd.com/read/29278732/loading-of-polymyxin-b-onto-anionic-mesoporous-silica-nanoparticles-retains-antibacterial-activity-and-enhances-biocompatibility
#17
Zahra Gounani, Mohammad A Asadollahi, Rikke L Meyer, Ayyoob Arpanaei
Polymyxin B is a polycationic antibiotic used as the last line treatment against antibiotic-resistant Gram negative bacteria. However, application of polymyxin B is limited because of its toxicity effects. Herein, we used bare and surface modified mesoporous silica nanoparticles (MSNs) with an average diameter of 72.29 ± 8.17 nm as adsorbent for polymyxin B to improve its therapeutic properties. The polymyxin B adsorption onto MSN surfaces was explained as a function of pH, type of buffer and surface charge of nanoparticles, according to the ζ-potential of silica nanoparticles and adsorption kinetics results...
December 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29277728/draft-genome-sequence-of-an-extensively-drug-resistant-xdr-pseudomonas-aeruginosa-belonging-to-st644-isolated-from-a-footpad-infection-in-a-magellanic-penguin-spheniscus-magellanicus
#18
Fábio P Sellera, Miriam R Fernandes, Quézia Moura, Tiago A Souza, Cristiane L Nascimento, Louise Cerdeira, Nilton Lincopan
OBJECTIVES: The incidence of multidrug-resistant (MDR) bacteria in wildlife animals has been investigated in order to improve the knowledge on the spreading of clinically relevant antimicrobial resistance genes. The aim of this study was to report the first draft genome sequence of an extensively drug-resistant (XDR) Pseudomonas aeruginosa ST644 recovered from a Magellanic penguin with footpad infection undergoing rehabilitation process. METHODS: Genome was sequenced on Illumina NextSeq platform, using paired-end reads (150bp)...
December 22, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29246635/the-evaluation-of-immunogenic-impact-of-selected-bacterial-recombinant-hsp60-antigens-in-dba-2j-mice
#19
Joanna Bajzert, Michał Gorczykowski, Józef Galli, Tadeusz Stefaniak
Heat Shock Proteins (HSP) are highly conserved proteins that are widely spread throughout all organisms. They function in the cytoplasm as chaperones; however, they could be expressed on the cell surface. It has been shown that Hsp60 obtained from gram-negative bacteria are able to stimulate cells of the acquired and innate immune system. The aim of this study was the evaluation of the immunogenic properties of recombinant Hsp60 proteins derived from four common pathogenic bacteria: Escherichia coli, Histophilus somni, Pasteurella multocida and Salmonella Enteritidis...
December 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29246087/in-silico-interaction-studies-suggest-rnd-efflux-pump-mediates-polymyxin-resistance-in-acinetobacter-baumannii
#20
Privita Verma, Pramila Maurya, Monalisa Tiwari, Vishvanath Tiwari
Bacterial efflux pumps have emerged as antibiotic resistance determinants and confers multi-drug resistance to a broad range of antimicrobials as well as non-antibiotic substances. A study about translocation of antibiotic molecules through the efflux transporter, will contribute in determining substrate specificity. In the present study, we have explored RND family efflux pump extensively found in Acinetobacter baumannii i.e. AdeABC. Besides, another well studied RND efflux pump, AcrAB-TolC together with a non-RND efflux pump, NorM were investigated for comparative analysis...
December 15, 2017: Journal of Biomolecular Structure & Dynamics
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