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deep infiltrating endometriosis

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https://www.readbyqxmd.com/read/28325119/conservative-management-in-ureteric-hydronephrosis-due-to-deep-endometriosis-could-the-levonorgestrel-intrauterine-device-be-an-option
#1
Elisa Simón, Álvaro Tejerizo, José Luis Muñoz, Carmen Álvarez, Laura Marqueta, Jesús S Jiménez
Endometriosis can affect up to 10% of women of reproductive age, in a wide range of clinical presentations that vary from mild to severe or deep endometriosis. Deep endometriosis can affect the urinary tract in 1-5% to 15-25% cases. Even though deep endometriosis' surgeries are usually complex with higher rate of complications, conservative management is not always considered as an option because of its high failure rates. This paper describes two cases of deep endometriosis with ureteric involvement (hydronephrosis) treated conservatively with a double-pigtail stent plus a Levonorgestrel intrauterine device, after conservative surgery, who remained symptom free with no evidence of recurrence at 3 years follow-up, avoiding radical high-risk surgery...
March 21, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28323223/robotic-assisted-conservative-excision-of-retrocervical-rectal-deep-infiltrating-endometriosis-a-case-series
#2
Alfredo Ercoli, Emma Bassi, Stefania Ferrari, Daniela Surico, Anna Fagotti, Francesco Fanfani, Fiorenzo De Cicco, Nicola Surico, Giovanni Scambia
Deep infiltrating endometriosis (DIE) is a complex disease that impairs the quality of life and the fertility of women. Colorectal DIE accounts for 70% to 93% of all the intestinal endometriotic sites and frequently needs a surgical approach. However, the indications for the surgical management of this condition are still controversial. From March 2010 to June 2014, we scheduled 33 consecutive patients presenting with retrocervical-rectal DIE of any diameter not involving the mucosa nor producing rectal stenosis > 50% for laparoscopic robotic assisted nerve-sparing rectal nodulectomy (LRN)...
March 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28303918/effects-of-matrix-stiffness-on-epithelial-to-mesenchymal-transition-like-processes-of-endometrial-epithelial-cells-implications-for-the-pathogenesis-of-endometriosis
#3
Sachiko Matsuzaki, Claude Darcha, Jean-Luc Pouly, Michel Canis
Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites. Our previous study revealed an epithelial to mesenchymal transition (EMT)-like process in red peritoneal endometriosis, whereas membrane localization of E-cadherin was well maintained in epithelial cells of deep infiltrating endometriosis (DIE). Here we show that endometrial epithelial cells (EEE) grown on polyacrylamide gel substrates (PGS) of 2 kilopascal (kPa), a soft matrix, initiate a partial EMT-like process with transforming growth factor-β1 (TGF-β1) stimulation...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290209/plasma-brain-derived-neurotrophic-factor-in-women-with-pelvic-pain-a-potential-biomarker-for-endometriosis
#4
Ana L Rocha, Erica L Vieira, Márcia C Ferreira, Laura M Maia, Antonio L Teixeira, Fernando M Reis
AIM: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. PATIENTS & METHODS: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. RESULTS: Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28271700/the-actual-role-of-robotics-in-the-management-of-endometriosis
#5
Vito Cela, Maria E Obino, Claudia Sergiampietri, Giovanna Simi, Francesca Papini, Sara Pinelli, Letizia Freschi, Paolo G Artini
The advent of robot-assisted laparoscopy (RAL) represents an important innovation and has opened new perspectives for treatment of endometriosis, in particular in deep infiltrating endometriosis (DIE). RAL could offer several technical advantages in treating this complex disease, such as 3D vision, tremor filtration and better surgical ergonomy, would be able to improve surgical performances without increasing in surgical time, blood loss, intra- and postoperative complications and it reduces the rates of conversion to laparotomy...
March 7, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28263049/is-there-a-role-of-single-port-laparoscopy-in-the-treatment-of-endometriosis
#6
Angelos Daniilidis, Kimon Chatzistamatiou, Efstratios Assimakopoulos
BACKGROUND: Endometriosis is among the most common benign gynecological conditions, and it affects 6-15% of women of reproductive. During recent decades, minimally invasive surgical techniques, and especially laparoscopy, have gained significant ground concerning the treatment of gynecological disorders. To date, laparoscopy is considered the gold standard for the diagnosis and treatment of endometriosis. METHODS: Available papers in Pub Med and Scopus data base, written in English language have been used for the current narrative review...
March 6, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28238309/-deep-infiltrative-endometriosis-without-digestive-involvement-what-is-the-impact-of-surgery-on-in-vitro-fertilization-outcomes-a-retrospective-study
#7
L Mounsambote, J Cohen, S Bendifallah, E Mathieu d'Argent, L Selleret, N Chabbert-Buffet, M Ballester, J M Antoine, E Daraï
OBJECTIVES: To evaluate the impact of complete removal of endometriosis in case of deep infiltrative endometriosis without digestive involvement, on in vitro fertilization outcomes. METHODS: Retrospective monocentric study. We included infertile women with deep infiltrative endometriosis without colorectal involvement that underwent IVF. Women were divided in two groups, following their history: "surgery" when they underwent complete endometriosis resection before IVF and "without surgery" when they underwent IVF without endometriosis removal...
January 2017: Gynecol Obstet Fertil Senol
https://www.readbyqxmd.com/read/28231497/dienogest-and-deep-infiltrating-endometriosis-the-remission-of-symptoms-is-not-related-to-endometriosis-nodule-remission
#8
Joao Paulo Leonardo-Pinto, Cristina Laguna Benetti-Pinto, Kleber Cursino, Daniela Angerame Yela
OBJECTIVE: To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions. STUDY DESIGN: A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) treated with dienogest 2mg per day for 12 months. We evaluated the pain symptoms and the volume of the intestinal and posterior fornix lesions before and after 12 months of use of dienogest...
February 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28187404/potentized-estrogen-in-homeopathic-treatment-of-endometriosis-associated-pelvic-pain-a-24-week-randomized-double-blind-placebo-controlled-study
#9
Marcus Zulian Teixeira, Sérgio Podgaec, Edmund Chada Baracat
OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). STUDY DESIGN: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score≥5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain...
January 25, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28186620/an-update-on-the-diagnosis-surgical-management-and-fertility-outcomes-for-women-with-endometrioma
#10
REVIEW
Ryan Cranney, George Condous, Shannon Reid
Endometriosis is estimated to affect up to 50% of infertile women, and severity of endometriosis stage appears to correlate with reduced fertility. Ovarian endometriomas are found in up to 44% of women with endometriosis, and are significantly associated with the presence of pelvic deep infiltrating endometriosis, ovarian adhesions, and pouch of Douglas obliteration. Through the use of MEDLINE and PubMed databases, we conducted a literature review of all available research related to the diagnosis, surgical management and fertility outcomes for women with endometrioma...
February 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28139235/functional-outcomes-after-disc-excision-in-deep-endometriosis-of-the-rectum-using-transanal-staplers-a%C3%A2-series-of-111-consecutive-patients
#11
Horace Roman, Basma Darwish, Valérie Bridoux, Rachid Chati, Sabrina Kermiche, Julien Coget, Emmanuel Huet, Jean-Jacques Tuech
OBJECTIVE: To assess the postoperative outcomes of patients with rectal endometriosis managed by disc excision using transanal staplers. DESIGN: Prospective study using data recorded in the CIRENDO database (NCT02294825). SETTING: University tertiary referral center. PATIENT(S): A total of 111 consecutive patients managed between June 2009 and June 2016. INTERVENTION(S): We performed rectal disc excision using two different transanal staplers: [1] the Contour Transtar stapler (the Rouen technique); and [2] the end to end anastomosis circular transanal stapler...
January 27, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28109703/investigation-of-anogenital-distance-as-a-diagnostic-tool-in-endometriosis
#12
Maria L Sánchez-Ferrer, Jaime Mendiola, Raquel Jiménez-Velázquez, Laura Cánovas-López, Shiana Corbalán-Biyang, Ana I Hernández-Peñalver, Ana Carmona-Barnosi, Ana B Maldonado-Cárceles, Maria T Prieto-Sánchez, Francisco Machado-Linde, Anibal Nieto, Alberto M Torres-Cantero
An association between anogenital distance (AGD) and endometriosis has been reported, suggesting that AGD may be a useful clinical tool in endometriosis. The predictive ability of AGD of women in discriminating presence and type of endometriosis was examined. A case-control study was conducted at the University Hospital 'Virgen de la Arrixaca', Murcia, Spain, between 2014 and 2015. A total of 114 participants diagnosed with endometriosis using ultrasound findings and 105 controls were recruited. Two AGD measurements were obtained: one from the anterior clitoral surface to the upper verge of the anus (AGDAC), and another one from the posterior fourchette to the upper verge of the anus (AGDAF)...
January 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28089810/laparoscopic-management-of-ureteral-endometriosis-and-hydronephrosis-associated-with-endometriosis
#13
João Alves, Marco Puga, Rodrigo Fernandes, Anne Pinton, Ignacio Miranda, Elias Kovoor, Arnaud Wattiez
STUDY OBJECTIVES: To evaluate if laparoscopic treatment of ureteral endometriosis is feasible, safe, and effective and to determine if ureteral dilatation and/or the number of incisions increases complications. DESIGN: An institutional review board-approved retrospective cohort study of consecutive patients who underwent surgery for deep infiltrating endometriosis involving the ureter with hydronephrosis (Canadian Task Force Classification III) SETTING: University hospital PARTICIPANTS: Of 658 patients who had surgery for deep infiltrating endometriosis between November 2004 and December 2013, 198 of the 658 patients had ureteral endometriosis and required ureterolysis, and 28 of the 198 patients were identified with ureteral dilatation and hydronephrosis associated with endometriosis...
January 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28076877/ultrasound-imaging-for-ovarian-and-deep-infiltrating-endometriosis
#14
Caterina Exacoustos, Errico Zupi, Emilio Piccione
The main challenges of imaging for endometriosis are the detection of nonovarian disease and the evaluation of the extension of the disease into pelvic structures. Transvaginal ultrasonography (TVS) has been proposed as the first-line imaging technique because it allows extensive exploration of the pelvis. The "typical" endometrioma is a unilocular cyst with homogeneous low-level echogenicity (ground glass echogenicity) of the cyst fluid. The use of color Doppler helps avoid classifying malignancies as endometriomas, defining the presence of vascular flow in papillations...
January 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28049501/the-abnormal-expression-of-oxytocin-receptors-in-the-uterine-junctional-zone-in-women-with-endometriosis
#15
Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu, Zhaolian Wei
BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis...
January 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28049215/surgical-management-of-endometriosis-in-patients-with-chronic-pelvic-pain
#16
Rebecca Flyckt, Suejin Kim, Tommaso Falcone
Surgical approaches to endometriosis patients with chronic pelvic pain are multimodal and require individualization. Laparoscopic approaches are preferred over laparotomy when conservatively treating endometriosis via excision or ablation/fulguration of lesions. The available data support cystectomy over fenestration or fulguration for endometriomas; however, there may be associated decreases in ovarian reserve with endometrioma treatment. Presacral neurectomy may be useful in patients with midline pain and LUNA is not effective for the treatment of pelvic pain related to endometriosis...
January 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28003801/deep-infiltrating-endometriosis-affecting-the-urinary-tract-surgical-treatment-and-fertility-outcomes-in-2004-2013
#17
Liisu Saavalainen, Oskari Heikinheimo, Aila Tiitinen, Päivi Härkki
Urinary tract endometriosis (UTE) is a rare form of deep infiltrating endometriosis. We studied the operative treatment of UTE and evaluated postoperative recurrences and fertility outcomes. This is a retrospective cohort study of 53 women who underwent operative treatment for UTE in 2004-2013 at Helsinki University Hospital, and were followed-up until the end of 2014. The data were gathered from the hospital's electronic database. The main outcome measures were complications, reoperations, postoperative pregnancies, and deliveries...
2016: Gynecological Surgery
https://www.readbyqxmd.com/read/27989989/total-circulating-microparticle-levels-are-increased-in-patients-with-deep-infiltrating-endometriosis
#18
J Munrós, M A Martínez-Zamora, D Tàssies, J L Coloma, M A Torrente, J C Reverter, F Carmona, J Balasch
STUDY QUESTION: Are the levels of total circulating cell-derived microparticles (cMPs) and circulating tissue factor-containing microparticles (cMP-TF) increased in patients with endometriosis? SUMMARY ANSWER: The levels of total cMP, but not cMP-TF, were higher in patients with endometriosis, and these were attributed to higher levels in patients with deep infiltrating endometriosis (DIE). WHAT IS KNOWN ALREADY: Previous studies have reported elevated levels of total cMP in inflammatory conditions as well as higher levels of other inflammatory biomarkers in endometriosis...
December 17, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27987565/economic-burden-of-deep-infiltrating-endometriosis-of-the-bowel-and-the-bladder-in-germany-the-statutory-health-insurance-perspective
#19
Katharina C Koltermann, Andreas Schlotmann, Helmut Schröder, Stefan N Willich, Thomas Reinhold
BACKGROUND: Until now, there has been little discussion of the costs of the deep infiltrating endometriosis (DIE) of the bowel or the bladder. The aim of the present secondary data analysis was to describe the population affected by this disease and to determine the economic burden in Germany from a payer's perspective. METHODS: Health claims data of women diagnosed with DIE of the bladder or bowel, who were surgically treated as inpatients between Jan 1, 2008 and Dec 31, 2012, were evaluated retrospectively...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27951614/nerve-sparing-and-surgery-for-deep-infiltrating-endometriosis-pessimism-of-the-intellect-or-optimism-of-the-will
#20
Basma Darwish, Horace Roman
Nerve-sparing surgery is an emerging technique for surgery-related dysfunction. Within the past 15 years, an essential progress in recognition and understanding of the anatomy of the pelvic autonomous nervous system has been made. Surgical preservation of vegetative nerves has become well known in many cancer centers. The technique has led to improvement of the quality of life following oncologic radical procedures. Positive results have led to the adoption of such techniques in the surgical treatment of deep infiltrating endometriosis in an aim to prevent urinary, rectal, and sexual dysfunction...
January 2017: Seminars in Reproductive Medicine
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