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deep infiltrating endometriosis

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https://www.readbyqxmd.com/read/28510724/relationship-between-the-magnetic-resonance-imaging-appearance-of-adenomyosis-and-endometriosis-phenotypes
#1
Charles Chapron, Claudia Tosti, Louis Marcellin, Mathilde Bourdon, Marie-Christine Lafay-Pillet, Anne-Elodie Millischer, Isabelle Streuli, Bruno Borghese, Felice Petraglia, Pietro Santulli
STUDY QUESTION: What is the relationship between endometriosis phenotypes superficial peritoneal endometriosis (SUP), ovarian endometrioma (OMA), deep infiltrating endometriosis (DIE) and the adenomyosis appearance by magnetic resonance imaging (MRI)? SUMMARY ANSWER: Focal adenomyosis located in the outer myometrium (FAOM) was observed more frequently in women with endometriosis, and was significantly associated with the DIE phenotype. WHAT IS KNOWN ALREADY: An association between endometriosis and adenomyosis has been reported previously, although data regarding the association between MRI appearance of adenomyosis and the endometriosis phenotype are currently still lacking...
May 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28501371/endometriosis-on-the-uterosacral-ligament-a-marker-of-ureteral-involvement
#2
Raquel Lima, Helizabet Abdalla-Ribeiro, Ana Luisa Nicola, Aline Eras, Anna Lobao, Paulo Ayroza Ribeiro
OBJECTIVE: To evaluate the association between ultrasound measurements of endometriosis nodules on the uterosacral ligament (USL) and the risk of ureteral involvement, as well as to assess whether associations with other ultrasound variables increase the sensitivity and specificity of the diagnosis of ureteral endometriosis. DESIGN: Cross-sectional, observational study. SETTING: University hospital. PATIENT(S): Four hundred sixty-three women with deep infiltrating endometriosis (DIE)...
May 10, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28489996/cancer-associated-mutations-in-endometriosis-without-cancer
#3
Michael S Anglesio, Nickolas Papadopoulos, Ayse Ayhan, Tayyebeh M Nazeran, Michaël Noë, Hugo M Horlings, Amy Lum, Siân Jones, Janine Senz, Tamer Seckin, Julie Ho, Ren-Chin Wu, Vivian Lac, Hiroshi Ogawa, Basile Tessier-Cloutier, Rami Alhassan, Amy Wang, Yuxuan Wang, Joshua D Cohen, Fontayne Wong, Adnan Hasanovic, Natasha Orr, Ming Zhang, Maria Popoli, Wyatt McMahon, Laura D Wood, Austin Mattox, Catherine Allaire, James Segars, Christina Williams, Cristian Tomasetti, Niki Boyd, Kenneth W Kinzler, C Blake Gilks, Luis Diaz, Tian-Li Wang, Bert Vogelstein, Paul J Yong, David G Huntsman, Ie-Ming Shih
BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS: We analyzed deeply infiltrating endometriotic lesions from 27 patients by means of exomewide sequencing (24 patients) or cancer-driver targeted sequencing (3 patients)...
May 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28486700/dysregulation-of-the-adam17-notch-signalling-pathways-in-endometriosis-from-oxidative-stress-to-fibrosis
#4
Iñaki González-Foruria, Pietro Santulli, Sandrine Chouzenoux, Francisco Carmona, Charles Chapron, Frédéric Batteux
STUDY QUESTION: Is oxidative stress associated with the A disintegrin and metalloproteases (ADAM) metallopeptidase domain 17 (ADAM17)/Notch signalling pathway and fibrosis in the development of endometriosis? SUMMARY ANSWER: Oxidative stress is correlated with hyperactivation of the ADAM17/Notch signalling pathway and a consequent increase in fibrosis in patients with endometriosis. WHAT IS KNOWN ALREADY: It is nowadays accepted that oxidative stress plays an important role in the onset and progression of endometriosis...
May 9, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28478727/local-upregulation-of-transient-receptor-potential-ankyrin-1-and-transient-receptor-potential-vanilloid-1-ion-channels-in-rectosigmoid-deep-infiltrating-endometriosis
#5
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators. They are also present on the rat endometrium in an oestrogen-regulated manner. TRPV1 is upregulated in peritoneal and ovarian endometriosis patients, but there is no information about TRPA1 and their pathophysiological significances. In this study, patients undergoing laparoscopic surgery were investigated: severe dysmenorrhoea due to rectosigmoid deep infiltrating endometriosis ( n = 15), uterine fibroid-induced moderate dysmenorrhoea ( n = 7) and tubal infertility with no pain ( n = 6)...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28445777/five-year-follow-up-after-laparoscopic-large-nerve-resection-for-deep-infiltrating-sciatic-nerve-endometriosis
#6
Marc Possover
STUDY OBJECTIVE: To report neurologic follow-up of patients after laparoscopic large resection of deep infiltrating endometriosis of the sciatic nerve. DESIGN: Prospective clinical case series (Canadian Task Force classification I). SETTING: Tertiary referral unit specializing in advanced gynecologic surgery and neuropelveology. PATIENTS: All data for patients who underwent laparoscopic surgery for endometriosis of the sciatic nerve between 2004 and 2016 (N = 259) were documented prospectively...
April 23, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28435128/randomized-trial-on-fast-track-care-in-colorectal-surgery-for-deep-infiltrating-endometriosis
#7
Marco Scioscia, Marcello Ceccaroni, Irene Gentile, Roberto Rossini, Roberto Clarizia, Davide Brunelli, Giacomo Ruffo
STUDY OBJECT: To study the application of a fast-track care protocol in colorectal surgery for deep infiltrating endometriosis. Bowel endometriosis is an infrequent but not rare condition that often needs intestinal surgery and imposes a high economic burden on society. DESIGN: Prospective randomized trial (Canadian Task Force I). SETTING: Tertiary referral center. PATIENTS: We randomly assigned 227 patients with preoperative evidence of bowel endometriosis to a fast-track (no preoperative bowel preparation, early restoration of diet, no postoperative antibiotics, and early post-operative mobilization) or conventional care for laparoscopic intestinal surgery...
April 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28419418/does-surgery-for-deep-infiltrating-bowel-endometriosis-improve-fertility-a-review
#8
Maja Lundegaard Iversen, Mikkel Seyer-Hansen, Axel Forman
INTRODUCTION: Reduced fertility is a major concern in women with endometriosis. The influence of surgery of deep infiltrating endometriosis (DIE) affecting the bowel wall on fertility is controversial and the literature on this field is heterogenous. In this review we addressed if surgery for bowel DIE improves spontaneous pregnancy rate and results of in vitro fertilization (IVF), and the potential risk of such surgery. MATERIAL AND METHODS: We conducted a literature search including the terms "deep", "deep infiltrating", "bowel", rectovaginal", "endometriosis", "fertility", "infertility" and "IVF" in Pubmed...
April 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28414865/transvaginal-sonography-in-the-diagnosis-of-deep-infiltrating-endometriosis-a-review
#9
Jenna M Turocy, Beryl R Benacerraf
This review summarizes the current evidence regarding the diagnostic accuracy of sonography (US) in women with deep infiltrating endometriosis (DIE). It is well known that transvaginal ultrasound (TVUS) can detect ovarian endometriomas with a high degree of sensitivity. In recent years, US has also been used to detect DIE. In the hands of an experienced sonologist, the sensitivity and specificity of TVUS in the detection of DIE is comparable to those of MRI. TVUS can eliminate the need for an MRI in the majority of patients and reduce the need for diagnostic laparoscopy, proving to be an important tool in preoperative planning...
April 17, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28407512/impact-of-large-ovarian-endometriomas-on-the-response-to-superovulation-for-in-vitro-fertilization-a-retrospective-study
#10
Simone Ferrero, Carolina Scala, Emanuela Tafi, Annalisa Racca, Pier Luigi Venturini, Umberto Leone Roberti Maggiore
OBJECTIVE: To assess the response to superovulation for in vitro fertilization (IVF) in patients with unilateral endometriomas with diameter ≥5cm and in the contralateral healthy ovary. STUDY DESIGN: This retrospective analysis of a prospectively collected database included patients who underwent superovulation for IVF/ICSI cycles and had unoperated single unilateral endometrioma with diameter ≥5cm and healthy contralateral ovary. The primary outcome of the study was to compare the number of oocyte retrieved in the ovary with the endometrioma and the contralateral healthy ovary...
April 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28403973/a-national-snapshot-of-the-surgical-management-of-deep-infiltrating-endometriosis-of-the-rectum-and-colon-in-france-in-2015-a-multicenter-series-of-1135-cases
#11
H Roman
OBJECTIVE: To perform a survey on the characteristics of the surgical management of patients with deep infiltrating endometriosis of the rectum and the sigmoid colon (DIERS) in France in 2015. METHOD: Case-series study enrolling patients with DIERS involving muscularis, submucosa or mucosa, operated on from January 1st to December 31st 2015, in 56 healthcare facilities in France. Surgeons filled in questionnaires concerning the number of patients, deep endometriosis localizations, surgical route and techniques used on digestive tract, associated surgical procedures and major complications...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28403970/fertility-after-surgery-for-deep-infiltrating-endometriosis
#12
M Blanc, P von Theobald
OBJECTIVES: The population of Reunion Island has a high prevalence of endometriosis impacting fertility. The aim of this series is to assess the fertility of women undergoing surgical approach of deep infiltrating endometriosis and to study the characteristics of the pregnancy outcomes. MATERIAL AND METHODS: This is a retrospective 2 centers study, including all women wanting to be pregnant and operated for deep endometriosis in any of the 2 hospitals of the CHU of Reunion Island between January 2012 and May 2013...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28403962/management-of-deep-infiltrating-endometriosis-by-laparoscopic-route-with-robotic-assistance-3-year-experience
#13
C Abo, H Roman, V Bridoux, E Huet, J-J Tuech, B Resch, E Stochino, L Marpeau, B Darwish
OBJECTIVE: To assess the feasibility of deep endometriosis surgery using robotic assistance, benefits and limits of this approach. METHOD: Case-series study enrolling patients managed for deep infiltrating endometriosis (DIE) using robotic assistance in our department between September 2011 and March 2014 (NCT02294825). Self-questionnaires including pain and digestive symptoms were filled in preoperatively and 1 year after surgery. RESULTS: Thirty-five patients were enrolled in the series...
January 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28403919/ureterovesical-reimplantation-for-ureteral-deep-infiltrating-endometriosis-a-retrospective-study
#14
A Chudzinski, P Collinet, V Flamand, C Rubod
INTRODUCTION AND HYPOTHESIS: Symptoms of endometriosis of the urinary tract consist of nonspecific signs that are often trivialized. However, late diagnosis may be responsible for an upstream impact. The aim of this study is to describe a population of patients who received ureterovesical reimplantation for deep infiltrating endometriosis. We evaluate the preoperative clinical and radiological symptoms and long-term surgical outcomes. METHODS: All the endometriotic patients who underwent ureterovesical reimplantation at Lille university hospital between 2003 and 2013 were included retrospectively...
March 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28381080/bladder-endometriosis-a-summary-of-current-evidence
#15
Carlo Saccardi, Amerigo Vitagliano, Pietro Litta
Bladder endometriosis is a specific form of endometriosis characterized by the presence of endometrial glands and stroma in the detrusor muscle. Such disease may involve different sites of the bladder, most frequently the base and the dome, with various grade of infiltration. Bladder nodules typically coexists with other localizations of deep pelvic endometriosis, resulting in a wide variety of abdominal and urinary symptoms that may be overlooked by clinicians. In spite of advances in understanding the genetic and molecular development of endometriosis, the clinical approach to bladder lesions is very challenging and may require the use of different diagnostic tools in order to set up a comprehensive diagnostic workup and direct towards the most appropriate treatment...
April 4, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28345488/deep-infiltrating-endometriosis-and-endometrial-adenocarcinoma-express-high-levels-of-myostatin-and-its-receptors-messenger-rnas
#16
Patrizia Carrarelli, Lucia Funghi, Pasquapina Ciarmela, Gabriele Centini, Fernando M Reis, Cynthia Dela Cruz, Alberto Mattei, Silvia Vannuccini, Felice Petraglia
Myostatin is a growth factor member of the transforming growth factor β superfamily, which is known to play major roles in cell proliferation and differentiation. The present study investigated the messenger RNA (mRNA) expression of myostatin and myostatin receptors (activin receptor-like kinase 4 [ALK4], transforming growth factor (TGF)-β type I receptor kinase [ALK5] and activin receptor type IIB [ActRIIB]) in endometrium of healthy women during menstrual cycle as well as in benign (endometriosis, polyps) and malignant (endometrial adenocarcinoma) conditions...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28342392/value-of-the-68-ga-dotatate-pet-ct-in-the-diagnosis-of-endometriosis-a-pilot-study
#17
M Fastrez, C Artigas, N Sirtaine, Z Wimana, M Caillet, S Rozenberg, P Flamen
OBJECTIVE: The non-invasive diagnosis of endometriosis remains challenging. Recent data suggested that somatostatin might be involved in its pathogenesis. High sensitive visualization of somatostatin receptors expression is possible using PET-CT imaging after the administration of a (68)Ga-labeled somatostatin analog (DOTATATE) that will bind to the somatostatin receptor sub-types 2 and 5. The aim of the present study was to assess the usefulness of (68)Ga-DOTATATE PET-CT in the diagnosis of endometriosis...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28325119/conservative-management-in-ureteric-hydronephrosis-due-to-deep-endometriosis-could-the-levonorgestrel-intrauterine-device-be-an-option
#18
Elisa Simón, Álvaro Tejerizo, José Luis Muñoz, Carmen Álvarez, Laura Marqueta, Jesús S Jiménez
Endometriosis can affect up to 10% of women of reproductive age, in a wide range of clinical presentations that vary from mild to severe or deep endometriosis. Deep endometriosis can affect the urinary tract in 1-5% to 15-25% cases. Even though deep endometriosis' surgeries are usually complex with higher rate of complications, conservative management is not always considered as an option because of its high failure rates. This paper describes two cases of deep endometriosis with ureteric involvement (hydronephrosis) treated conservatively with a double-pigtail stent plus a Levonorgestrel intrauterine device, after conservative surgery, who remained symptom free with no evidence of recurrence at 3 years follow-up, avoiding radical high-risk surgery...
March 21, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28323223/robotic-assisted-conservative-excision-of-retrocervical-rectal-deep-infiltrating-endometriosis-a-case-series
#19
Alfredo Ercoli, Emma Bassi, Stefania Ferrari, Daniela Surico, Anna Fagotti, Francesco Fanfani, Fiorenzo De Cicco, Nicola Surico, Giovanni Scambia
Deep infiltrating endometriosis (DIE) is a complex disease that impairs the quality of life and the fertility of women. Colorectal DIE accounts for 70% to 93% of all the intestinal endometriotic sites and frequently needs a surgical approach. However, the indications for the surgical management of this condition are still controversial. From March 2010 to June 2014, we scheduled 33 consecutive patients presenting with retrocervical-rectal DIE of any diameter not involving the mucosa nor producing rectal stenosis > 50% for laparoscopic robotic assisted nerve-sparing rectal nodulectomy (LRN)...
March 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28303918/effects-of-matrix-stiffness-on-epithelial-to-mesenchymal-transition-like-processes-of-endometrial-epithelial-cells-implications-for-the-pathogenesis-of-endometriosis
#20
Sachiko Matsuzaki, Claude Darcha, Jean-Luc Pouly, Michel Canis
Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites. Our previous study revealed an epithelial to mesenchymal transition (EMT)-like process in red peritoneal endometriosis, whereas membrane localization of E-cadherin was well maintained in epithelial cells of deep infiltrating endometriosis (DIE). Here we show that endometrial epithelial cells (EEE) grown on polyacrylamide gel substrates (PGS) of 2 kilopascal (kPa), a soft matrix, initiate a partial EMT-like process with transforming growth factor-β1 (TGF-β1) stimulation...
March 17, 2017: Scientific Reports
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