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deep infiltrating endometriosis

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https://www.readbyqxmd.com/read/29757096/when-solving-dyspareunia-is-not-enough-to-restore-sexual-function-in-women-with-deep-infiltrating-endometriosis-treated-with-dienogest
#1
João Paulo Leonardo-Pinto, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela
OBJECTIVE: The aim of the study was evaluated dyspareunia and sexual function (SF) in women with deep endometriosis treated with Dienogest for 12 months. METHODS: Prospective cohort study set in University of Campinas, Brazil, including thirty women with sonographic diagnosis of deep endometriosis and sexual dysfunction treated with 2░mg/daily Dienogest for 12 months. SF parameters were assessed by Female Sexual Function Index (FSFI) before and after the treatment and dyspareunia was quantified through Visual Analogic Scale(VAS) during the follow ups performed every 3 months...
May 14, 2018: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/29750706/immunohistochemical-analysis-of-somatostatin-receptors-in-endometriosis-tissue-samples-a-retrospective-study
#2
Maxime Fastrez, Camille Marchisello, Marc Rassy, Serge Rozenberg, Nicolas Sirtaine
Three types of endometriosis are described: superficial peritoneal endometriosis (SPE), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). The expression of somatostatin receptors (SSTR1, 2, and 5) in human endometrial tissue and its ectopic form has been previously studied and may be different in each type of endometriosis. The aim of this study was to assess the immunohistochemical expression of SSTR1, 2, and 5 in tissue samples of SPE, OMA, and DIE. We performed a retrospective analysis in the pathology department database...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29747214/intestinal-perforation-due-to-deep-infiltrating-endometriosis-during-pregnancy-case-report
#3
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Maria Das Graças Torres, Patrícia Salomé Gouvea, Ivete de Ávila
We report the case of a 33 year-old woman who complained of severe dysmenorrhea since menarche. From 2003 to 2009, she underwent 4 laparoscopies for the treatment of pain associated with endometriosis. After all four interventions, the pain recurred despite the use of gonadotropin-releasing hormone (GnRH) analogues and the insertion of a levonorgestrel intrauterine system (LNG-IUS). Finally, a colonoscopy performed in 2010 revealed rectosigmoid stenosis probably due to extrinsic compression. The patient was advised to get pregnant before treating the intestinal lesion...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29742675/risk-of-gynecologic-cancer-according-to-the-type-of-endometriosis
#4
Liisu Saavalainen, Heini Lassus, Anna But, Aila Tiitinen, Päivi Härkki, Mika Gissler, Eero Pukkala, Oskari Heikinheimo
OBJECTIVE: To assess the risks of gynecologic cancer according to the type of endometriosis in women with surgically verified endometriosis. METHODS: This is a population-based study of women with surgically verified endometriosis retrieved from the Finnish Hospital Discharge Register 1987-2012 (N=49,933); the subtypes of ovarian (n=23,210), peritoneal (n=20,187), and deep infiltrating (n=2,372) endometriosis were analyzed separately. Gynecologic cancers were obtained from the Finnish Cancer Registry...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29678755/colorectal-anastomotic-stenosis-lesson-learned-after-1643-colorectal-resections-for-deep-infiltrating-endometriosis
#5
Elisa Bertocchi, Giuliano Barugola, Marco Benini, Paolo Bocus, Roberto Rossini, Marcello Ceccaroni, Giacomo Ruffo
STUDY OBJECTIVE: To evaluate incidence, risk factors, and treatment of colorectal anastomotic stenosis in patients who underwent rectosigmoid resection for deep infiltrating endometriosis (DIE). DESIGN: A retrospective analysis of prospective database (Canadian Task Force classification III). SETTING: Public Medical Center PATIENTS: All women who underwent laparoscopic rectosigmoid resections for DIE between January 2002 and December 2016...
April 17, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29675360/deep-infiltrating-endometriosis-mr-imaging-with-surgical-correlation
#6
REVIEW
Xue Tang, Rennan Ling, Jingshan Gong, Dongdong Mei, Yan Luo, Minge Li, Jianmin Xu, Liguo Ma
In this pictorial review, MR imaging findings of deep infiltrating endometriosis (DIE) are illustrated together with surgical correlation. DIE can appear as irregular nodules or plaques with similar signal intensity to muscle on both T1-weighted and T2-weighted images. Hemorrhage foci and strands or stellate margins are also often noted. Restriction of diffusion can be seen on diffusion-weighted image. Fibrosis and adhesions often result in morphologic changes, such as alimentary tract tortuosity, irregular or nodular thickening of uterosacral ligaments, and partial or complete obliteration of the pouch of Douglas...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29666722/postmenopausal-deep-infiltrating-endometriosis-of-the-colon-rare-location-and-novel-medical-therapy
#7
Benjamin M Snyder, Joseph W Beets, Bruce A Lessey, Samuel R W Horton, Gary A Abrams
We report an uncommon case of deep infiltrating endometriosis of the colon presenting as iron deficiency anemia nine years after hysterectomy with bilateral salpingo-oophorectomy. The endometrial implant was found at the hepatic flexure, an exceedingly rare location for endometriosis invasion with no cases distinctly reported in the literature. Additionally, the presentation of gastrointestinal endometriosis as iron deficiency anemia is not well documented in the literature. Instead of surgery, we prescribed a novel medical therapeutic approach using conjugated estrogen-bazedoxifene to antagonize the proliferative effects of estrogen on endometrial tissue...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29664797/functional-outcomes-after-rectal-resection-for-deep-infiltrating-pelvic-endometriosis-long-term-results
#8
Suna Erdem, Sara Imboden, Andrea Papadia, Susanne Lanz, Michael D Mueller, Beat Gloor, Mathias Worni
BACKGROUND: Curative management of deep infiltrating endometriosis requires complete removal of all endometriotic implants. Surgical approach to rectal involvement has become a topic of debate given potential postoperative bowel dysfunction and complications. OBJECTIVE: This study aims to assess long-term postoperative evacuation and incontinence outcomes after laparoscopic segmental rectal resection for deep infiltrating endometriosis involving the rectal wall...
April 16, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29656149/total-laparoscopic-ureteroneocystostomy-for-ureteral-endometriosis-a-single-center-experience-of-160-consecutive-patients
#9
Marcello Ceccaroni, Matteo Ceccarello, Giuseppe Caleffi, Roberto Clarizia, Stefano Scarperi, Mauro Pastorello, Alberto Molinari, Giacomo Ruffo, Stefano Cavalleri
STUDY OBJECTIVE: To investigate the efficacy of laparoscopic ureteroneocystostomy in patients with deep infiltrating endometriosis (DIE) with ureteral, parametrial, and bowel involvement. DESIGN: Prospective study (Canadian Task Force classification II-2). SETTING: Tertiary referral center for endometriosis care. PATIENTS: One hundred and sixty patients with DIE underwent laparoscopic radical eradication and ureteroneocystostomy between January 2009 and December 2016...
April 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29609193/female-sexual-function-in-women-with-suspected-deep-infiltrating-endometriosis
#10
Ryane Vieira Lima, Ana Maria Gomes Pereira, Fernando Bray Beraldo, Cláudia Gazzo, João Alfredo Martins, Reginaldo Guedes Coelho Lopes
OBJECTIVE:  To evaluate the quality of the sexual function of women with suspected deep infiltrating endometriosis. METHODS:  A cross-sectional, observational and prospective study was conducted between May 2015 and August 2016, in which 67 patients with deep infiltrating endometriosis, suspected or diagnosed, were assessed for epidemiological and clinical characteristics, such as pain level through a visual analog scale (VAS), features of deep infiltrating endometriosis lesions and score on the Female Sexual Function Index (FSFI) before the onset of treatment...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29551300/-first-line-management-without-ivf-of-infertility-related-to-endometriosis-result-of-medical-therapy-results-of-ovarian-superovulation-results-of-intrauterine-insemination-cngof-has-endometriosis-guidelines
#11
J Boujenah, P Santulli, E Mathieu-d'Argent, C Decanter, C Chauffour, P Poncelet
INTRODUCTION: Using the structured methodology of French guidelines (HAS-CNGOF), the aim of this chapter was to formulate good practice points (GPP), in relation to optimal non-ART management of endometriosis related to infertility, based on the best available evidence in the literature. MATERIALS AND METHODS: This guideline was produced by a group of experts in the field including a thorough systematic search of the literature (from January 1980 to March 2017)...
March 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29547736/the-presence-of-kras-ppp2r1a-and-arid1a-mutations-in-101-chinese-samples-with-ovarian-endometriosis
#12
Yang Zou, Jiang-Yan Zhou, Jiu-Bai Guo, Li-Qun Wang, Yong Luo, Zi-Yu Zhang, Fa-Ying Liu, Jun Tan, Feng Wang, Ou-Ping Huang
Endometriosis is a potential premalignant disorder. The underlying molecular aberrations, however, are not fully understood. A recent exome sequencing study found that 25% (10/39) of deep infiltrating endometriosis harbored cancer driver gene mutations. However, it is unclear whether these mutations also exist in ovarian endometriosis. Here, a total of 101 ovarian endometriosis samples were analyzed for the presence of these gene mutations, including KRAS, PPP2R1A, PIK3CA and ARID1A. In addition, 6 other cancer-associated genes (BRAF, NRAS, HRAS, ERK1, ERK2 and PTEN) were also analyzed...
May 2018: Mutation Research
https://www.readbyqxmd.com/read/29545217/combined-transvaginal-transabdominal-pelvic-ultrasonography-accurately-predicts-the-3-dimensions-of-deep-infiltrating-bowel-endometriosis-measured-after-surgery-a-prospective-study-in-a-specialized-center
#13
Alessandra Di Giovanni, Lucia Casarella, Marina Coppola, Domenico Iuzzolino, Marianna Rasile, Mario Malzoni
STUDY OBJECTIVE: To assess the sensitivity and accuracy of combined transvaginal/ transabdominal ultrasonography (TV/TA US) for evaluation of deep infiltrating bowel endometriosis nodules measured after surgery. DESIGN: Prospective study (Canadian Task Force classification II.1). SETTING: A center for advanced endoscopic gynecologic surgery. PATIENTS: All women undergoing laparoscopic surgery and scheduled for segmental resection for clinically suspected bowel endometriosis between January 2014 and December 2016...
March 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29544710/-deeply-infiltrating-endometriosis-and-infertility-cngof-has-endometriosis-guidelines
#14
E Mathieu d'Argent, J Cohen, C Chauffour, J L Pouly, J Boujenah, C Poncelet, C Decanter, P Santulli
Deeply infiltrating endometriosis is a severe form of the disease, defined by endometriotic tissue peritoneal infiltration. The disease may involve the rectovaginal septum, uterosacral ligaments, digestive tract or bladder. Deeply infiltrating endometriosis is responsible for disabling pain and infertility. The purpose of these recommendations is to answer the following question: in case of deeply infiltrating endometriosis associated infertility, what is the best therapeutic strategy? First-line surgery and then in vitro fertilization (IVF) in case of persistent infertility or first-line IVF, without surgery? After exhaustive literature analysis, we suggest the following recommendations: studies focusing on spontaneous fertility of infertile patients with deeply infiltrating endometriosis found spontaneous pregnancy rates about 10%...
March 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29540335/-definition-description-clinicopathological-features-pathogenesis-and-natural-history-of-endometriosis-cngof-has-endometriosis-guidelines
#15
B Borghese, P Santulli, L Marcellin, C Chapron
Endometriosis and adenomyosis are histologically defined. The frequency of endometriosis cannot be precisely estimated in the general population. Endometriosis is considered a disease when it causes pain and/or infertility. Endometriosis is a heterogeneous disease with three well-recognized subtypes that are often associated with each other: superficial endometriosis (SUP), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). DIE is frequently multifocal and mainly affects the following structures: the uterosacral ligaments, the posterior vaginal cul-de-sac, the bladder, the ureters, and the digestive tract (rectum, recto-sigmoid junction, appendix)...
March 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29540112/enhanced-ugt1a1-gene-and-protein-expression-in-endometriotic-lesions
#16
Carla A Piccinato, Rosa M Neme, Natália Torres, Elivane da Silva Victor, Heloísa F Brudniewski, Júlio C Rosa E Silva, Rui A Ferriani
The cellular function in endometriosis lesions depends on a highly estrogenic milieu. Lately, it is becoming evident that, besides the circulating levels of estrogens, the balance of synthesis versus inactivation (metabolism) of estrogens by intralesion steroid-metabolizing enzymes also determines the local net estrogen availability. In order to extend the knowledge of the role of estrogen-metabolizing enzymes in endometriosis, we investigated the gene and protein expression of a key uridine diphospho-glucuronosyltransferase (UGT) for estrogen glucuronidation, UGT1A1, in eutopic endometrial samples obtained from nonaffected and endometriosis-affected women and also from endometriotic lesions...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29534879/-surgical-management-of-deep-endometriosis-with-colorectal-involvement-cngof-has-endometriosis-guidelines
#17
M Ballester, H Roman
Deep endometriosis with colorectal involvement is considered one of the most severe forms of the disease due to its impact on patients' quality of life and fertility but also by the difficulties encountered by the clinicians when proposing a therapeutic strategy. Although the literature is very rich, evidence based medicine remains poor explaining the great heterogeneity concerning the management of such patients. Surgery therefore remains a therapeutic option. It improves the intensity of gynecological, digestive and general symptoms and the quality of life...
March 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29534377/-analysis-of-characteristics-and-influence-factors-of-diagnostic-delay-of-endometriosis
#18
X T Han, H Y Guo, D L Kong, J S Han, L F Zhang
Objective: To access the influence factors of diagnostic delay of endometriosis. Methods: We designed a questionnaire of diagnostic delay of endometriosis. From February 2014 to February 2016, 400 patients who had dysmenorrhea and diagnosed with endometriosis by surgery in Peking University Third Hospital were surveyed retrospectively. Time and risk factors of diagnostic delay were analyzed. Results: The diagnostic delay of 400 patients was 13.0 years (0.2-43.0 years), 78.5%(314/400) patients thought pain was a normal phenomenon and didn't see the doctor...
February 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29530559/-specific-clinical-signs-suggestive-of-endometriosis-excluding-adenomyosis-and-questionnaires-of-symptoms-pain-and-quality-of-life-cngof-has-endometriosis-guidelines
#19
C Huchon, G Aubry, S Ploteau, A Fauconnier
In case of consultation for chronic pelvic pain or suspicion of endometriosis, it is recommended to evaluate the pain (intensity, resonance) and to search out the evocative and localizing symptoms of endometriosis (Grade B). The main symptoms suggestive of endometriosis are: severe dysmenorrhea (NP2), deep dyspareunia (NP2), painful defecation during menstruation (NP2), urinary tract symptoms during menstruation (NP2) and infertility (NP2). In patients with chronic pelvic pain, it is recommended to search deep infiltrating endometriosis in patients with painful defecation during menstruation or severe deep dyspareunia (Grade B)...
March 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29530425/medical-treatment-of-endometriosis-related-pain
#20
REVIEW
Paolo Vercellini, Laura Buggio, Maria Pina Frattaruolo, Alessandra Borghi, Dhouha Dridi, Edgardo Somigliana
Available medical treatments for symptomatic endometriosis act by inhibiting ovulation, reducing serum oestradiol levels, and suppressing uterine blood flows. For this, several drugs can be used with a similar magnitude of effect, in terms of pain relief, independently of the mechanism of action. Conversely, safety, tolerability, and cost differ. Medications for endometriosis can be categorized into low-cost drugs including oral contraceptives (OCs) and most progestogens, and high-cost drugs including dienogest and GnRH agonists...
February 15, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
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