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Tuberculosis and diabetes mellitus

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https://www.readbyqxmd.com/read/28543817/influence-of-diabetes%C3%A2-mellitus-on-the-immunity-to-human-tuberculosis
#1
REVIEW
Nathella Pavan Kumar, Subash Babu
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis, with development of DM pandemic in countries where tuberculosis (TB) is also endemic. Understanding the impact of DM on TB and the determinants of co-morbidity is essential in responding to this growing public health problem with improved therapeutic approaches. Despite the clinical and public health significance posed by the dual burden of TB and DM, little is known about the immunological and biochemical mechanisms of susceptibility...
May 22, 2017: Immunology
https://www.readbyqxmd.com/read/28539734/honey-and-health-a-review-of-recent-clinical-research
#2
REVIEW
Saeed Samarghandian, Tahereh Farkhondeh, Fariborz Samini
Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times. Honey is used not only as a nutritional product but also in health described in traditional medicine and as an alternative treatment for clinical conditions ranging from wound healing to cancer treatment. The aim of this review is to emphasize the ability of honey and its multitude in medicinal aspects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28515464/systems-immunology-of-diabetes-tuberculosis-comorbidity-reveals-signatures-of-disease-complications
#3
Cesar A Prada-Medina, Kiyoshi F Fukutani, Nathella Pavan Kumar, Leonardo Gil-Santana, Subash Babu, Flávio Lichtenstein, Kim West, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Bruno B Andrade, Helder I Nakaya, Hardy Kornfeld
Comorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with and without DM to diabetic and non-diabetic controls without TB. Luminex assay of plasma cytokines and growth factors delineated a distinct biosignature in comorbid TBDM in this cohort. Transcriptional profiling revealed elements in common with published TB signatures from cohorts that excluded DM...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499359/cystic-fibrosis-carriership-and-tuberculosis-hints-toward-an-evolutionary-selective-advantage-based-on-data-from-the-brazilian-territory
#4
Lander Bosch, Barbara Bosch, Kris De Boeck, Tim Nawrot, Isabelle Meyts, Dominique Vanneste, Cleonice Alexandre Le Bourlegat, Julio Croda, Luiz Vicente Ribeiro Ferreira da Silva Filho
BACKGROUND: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis (Mtb) infection. METHODS: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis (TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2...
May 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28492777/tuberculosis-and-diabetes-probabilistic-linkage-of-databases-to-study-the-association-between-both-diseases
#5
Ricardo Gadelha de Abreu, Artur Iuri Alves de Sousa, Maria Regina Fernandes de Oliveira, Mauro Niskier Sanchez
OBJECTIVE: to describe the profile of cases of tuberculosis and diabetes comorbidity in Brazil. METHODS: this is a descriptive study with data from the Brazilian Information System for Notifiable Diseases - tuberculosis (Sinan-TB) and from the System of Registration and Monitoring of Hypertension and Diabetes Mellitus (Hiperdia), from 2007 to 2011; probabilistic linkage was carried out with Reclink software. RESULTS: 24,443 cases of comorbidity were found, including 3,181 cases not registered on Sinan-TB; of the total number of recovered cases, mostly were males (57...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28480422/bioactive-components-of-gynura-divaricata-and-its-potential-use-in-health-food-and-medicine-a-mini-review
#6
Bing-Qing Xu, Yu-Qing Zhang
BACKGROUND: G. divaricata (L.) DC belongs to genus the Gynura Cass which is a kind of perennial herb that has good health protection efficacy and is especially used widely in medicine and functional food. It is one of the most famous traditional Chinese medicinal herbs and is usually used to cure bronchitis, pulmonary tuberculosis, kink cough, rheumatism, diabetes, and so on. It has a long history for the treatment of diabetes mellitus in the folk medicine. This review is aimed at gathering all information relating to G...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28470109/the-change-in-blood-glucose-levels-in-tuberculosis-patients-before-and-during-anti-tuberculosis-treatment-in-china
#7
Yan Lin, Yanli Yuan, Xin Zhao, Jianmu Liu, Linxi Qiu, Xiaoxin He, Yunlong Bai, Bo Li, Zhong Zeng, Guangxu Yang, Xu Meng, Chunyu Yuan, Hailun Zheng, Wanli Kang, Anthony D Harries
OBJECTIVE: We aimed to observe (i) changes in fasting blood glucose (FBG) in tuberculosis (TB) patients before and during anti-TB treatment, (ii) whether FBG levels were stable or unstable and (iii) baseline characteristics associated with an unstable FBG. METHOD: TB patients consecutively attended six clinics or hospitals. FBG measurements were made at months 0, 2 and 6. Data analysis was performed using the chi-square test and multivariate logistic regression...
2017: Global Health Action
https://www.readbyqxmd.com/read/28459038/tuberculosis-and-diabetes-mellitus-tackling-dual-maladies-comment-on-bangladeshi-tuberculosis-diabetes-mellitus-guidelines
#8
Jyothi Idiculla
No abstract text is available yet for this article.
March 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28439071/diabetes-mellitus-and-the-risk-of-multidrug-resistant-tuberculosis-a-meta-analysis
#9
Qianqian Liu, Wenzhang Li, Miao Xue, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Lina Han, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-TB) patients is a serious cause for concern. We conducted a meta-analysis to determine whether DM is an independent risk factor for MDR-TB. Electronic literature searches of the PubMed, Web of Science and EMBASE databases up to July 12, 2016 were conducted. The pooled adjusted odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effects model with STATA 12.0 software. In total 13 studies, including 9289 individuals with TB, were included in this meta-analysis...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28430796/prevalence-and-associated-factors-of-tuberculosis-and-diabetes-mellitus-comorbidity-a-systematic-review
#10
Mahteme Haile Workneh, Gunnar Aksel Bjune, Solomon Abebe Yimer
INTRODUCTION: The dual burden of tuberculosis (TB) and diabetes mellitus (DM) has become a major global public health concern. There is mounting evidence from different countries on the burden of TB and DM comorbidity. The objective of this systematic review was to summarize the existing evidence on prevalence and associated/risk factors of TBDM comorbidity at global and regional levels. METHODS: Ovid Medline, Embase, Global health, Cochrane library, Web of science and Scopus Elsevier databases were searched to identify eligible articles for the systematic review...
2017: PloS One
https://www.readbyqxmd.com/read/28412726/inhaled-corticosteroids-have-a-protective-effect-against-lung-cancer-in-female-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-population-based-cohort-study
#11
Shih-Feng Liu, Ho-Chang Kuo, Meng-Chih Lin, Shu-Chen Ho, Mei-Lien Tu, Yu-Mu Chen, Yung-Che Chen, Wen-Feng Fang, Chin-Chou Wang, Guan-Heng Liu
Whether the use of inhaled corticosteroids (ICS) protects patients with chronic obstructive pulmonary disease (COPD) from lung cancer remains undetermined. In this retrospective nationwide population-based cohort study, we extracted data of 13,686 female COPD patients (ICS users, n = 1,290, ICS non-users, n = 12,396) diagnosed between 1997 and 2009 from the Taiwan's National Health Insurance database. These patients were followed-up until 2011, and lung cancer incidence was determined. Cox regression analysis was used to estimate hazard ratios (HRs) for lung cancer incidence...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28369346/epidemiology-of-latent-tuberculosis-infection-among-patients-with-and-without-diabetes-mellitus
#12
Yogarabindranath Swarna Nantha, Anurupa Puri, Siti Zubaidah Mohamad Ali, Poopathy Suppiah, Siti Aishah Che Ali, Bhavani Ramasamy, Intan Masni Ibrahim
Background.: Individuals with type 2 diabetes mellitus (DM) are at a greater risk of tuberculosis (TB) reactivation. There is a paucity of information about the risk factors associated with latent tuberculosis infection (LTBI) in patients with diabetes. Objective.: We conducted an observational study to compare the prevalence and risk factors associated with LTBI factors in Malaysian adults with and without DM. Methods.: Four hundred and four patients with DM and 359 patients with non-DM at a regional primary care clinic were recruited as participants in this case-control study...
March 23, 2017: Family Practice
https://www.readbyqxmd.com/read/28360440/effect-of-poor-glycemic-control-in-newly-diagnosed-patients-with-smear-positive-pulmonary-tuberculosis-and-type-2-diabetes-mellitus
#13
Vinay Mahishale, Sindhuri Avuthu, Bhagyashri Patil, Mitchelle Lolly, Ajith Eti, Sujeer Khan
BACKGROUND: There is growing evidence that diabetes mellitus (DM) is an important risk factor for tuberculosis (TB). A significant number of DM patients have poor glycemic control. This study was carried out to find the impact of poor glycemic control on newly diagnosed smear-positive pulmonary tuberculosis patients with type-2 diabetes mellitus in a tertiary care hospital. METHODS: In a hospital-based prospective study, newly diagnosed smear-positive pulmonary TB with DM patients were classified as poorly controlled diabetes (HBA1C≥7%) and optimal control diabetics (HbA1c<7%)...
March 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28349016/screening-of-tuberculosis-patients-for-diabetes-mellitus-is-feasible-with-the-existing-health-system-in-india
#14
Janmejaya Samal
No abstract text is available yet for this article.
October 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28317813/association-between-pulmonary-tuberculosis-and-type-2-diabetes-in-sudanese-patients
#15
Mona Ahmed, Ibtihal Omer, Sannaa M A Osman, Eltayib H Ahmed-Abakur
INTRODUCTION: Tuberculosis (TB) and diabetes mellitus (DM) are both important health issues, and the association between DM and TB may be the next challenge for global TB control worldwide, type 2 DM (T2DM) responsible for 90% of DM cases. Persons with diabetes have a significantly increased risk of active TB, which is two to three times higher than in persons without diabetes. The aim of this study was to determine the association between pulmonary tuberculosis (PTB) and T2DM among Sudanese patients and also to determine the association between hemoglobin A1c (HbA1c) percentage in diabetic patients and development of PTB and effect of duration of T2DM in developing PTB...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28293059/persistent-marked-peripheral-eosinophilia-due-to-tuberculosis-a-case-report
#16
Gunjan Garg, Atul Gogia, Atul Kakar, Pratyush Miglani
We report a case of a 68-year-old female who was a known case of diabetes mellitus and chronic liver disease and presented with complaints of dry cough and other constitutional symptoms since one month. During initial investigations, the patient was found to have peripheral blood eosinophilia. Upon investigating further,the patient was found to have mediastinal lymphadenopathy and fine-needle aspiration of mediastinal lymph nodes showed features of tuberculosis. The patient was started on anti-tubercular treatment and her eosinophil counts returned to normal levels...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28292352/prevalence-and-risk-factors-associated-with-adverse-drug-reactions-among-previously-treated-tuberculosis-patients-in-china
#17
Xi Qin Han, Yu Pang, Yan Ma, Yu Hong Liu, Ru Guo, Wei Shu, Xue Rui Huang, Qi Ping Ge, Jian DU, Wei Wei Gao
We assessed the incidence of adverse drug reactions (ADRs) with anti-TB medications and evaluated the risk factors for developing ADRs in previously treated tuberculosis patients in China. All patients received the first-line anti-TB regimen (2HREZS/6HRE) as recommended by the national guidelines. Clinical and laboratory evaluations were performed once a month. Out of the 354 participants, 262 (74.0%) experienced ADRs such as hyperuricemia (65.0%, 230/354), hepatotoxicity (6.2%, 22/354) and hearing disturbances (4...
February 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28281682/screening-for-diabetes-mellitus-among-tuberculosis-patients-in-southern-nigeria-a-multi-centre-implementation-study-under-programme-settings
#18
Ngozi Ekeke, Kingsley N Ukwaja, Joseph N Chukwu, Charles C Nwafor, Anthony O Meka, Eruke E Egbagbe, Festus O Soyinka, Isaac Alobu, Ifeanyi Agujiobi, Samuel Akingbesote, Osagie Igbinigie, Job B Offor, Nelson O Madichie, Chukwuka Alphonsus, Moses C Anyim, Obinna K Mbah, Daniel C Oshi
Implementation studies are recommended to assess the feasibility and effectiveness of programmes. In Nigeria, little is known about the burden of diabetes mellitus (DM) among tuberculosis (TB) patients. The objective of this study was to determine screening efficacy, prevalence of DM and determinants of DM among TB patients. We report on a multi-centre implementation study carried-out in 13 health facilities in six States of Southern Nigeria. All newly diagnosed TB patients registered from March to October 2015 were screened for DM using current World Health Organisation guidelines...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275494/chronic-pulmonary-mucormycosis-an-emerging-fungal-infection-in-diabetes-mellitus
#19
Nousheen Iqbal, Muhammad Irfan, Kauser Jabeen, Murtaza Mohammed Kazmi, Muhammad Usman Tariq
Mucormycosis commonly affects immunocompromised individuals with defects in neutrophil function or count. Diabetes mellitus is an important risk factor due to impair innate and acquired immunity for mucormycosis, with rhino-orbital-cerebral involvement as a common presentation. Pulmonary mucormycosis (PM) although a rare presentation in diabetic patients but is associated with high mortality and morbidity. An early diagnosis of PM is difficult, due to rarity of the disease and clinical and radiological features resembling tuberculosis (TB) which is common in Pakistan...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28245792/association-between-body-mass-index-and-diabetes-mellitus-in-tuberculosis-patients-in-china-a-community-based-cross-sectional-study
#20
Jing Cai, Aiguo Ma, Qiuzhen Wang, Xiuxia Han, Shanliang Zhao, Yu Wang, Evert G Schouten, Frans J Kok
BACKGROUND: We planned to determine the association of body mass index (BMI) with diabetes mellitus (DM) and impaired fasting glucose (IFG) in Chinese pulmonary tuberculosis (PTB) patients. METHODS: 3,505 newly-diagnosed PTB patients registered in PTB clinics in Linyi of China between September 2010 and March 2013 were enrolled. DM and IFG were identified based on fasting plasma glucose levels. ROC analysis was used to predict the ability of screening of BMI for DM and IFG in PTB patients...
February 28, 2017: BMC Public Health
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