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Tuberculosis and diabetes mellitus

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https://www.readbyqxmd.com/read/28088237/association-between-diabetes-mellitus-and-multi-drug-resistant-tuberculosis-a-protocol-for-a-systematic-review-and-meta-analysis
#1
Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28043788/comparison-of-bacteriological-conversion-and-treatment-outcomes-among-mdr-tb-patients-with-and-without-diabetes-in-mexico-preliminary-data
#2
M Muñoz-Torrico, J Caminero Luna, G B Migliori, L D'Ambrosio, J L Carrillo-Alduenda, H Villareal-Velarde, A Torres-Cruz, H Flores-Ergara, D Martínez-Mendoza, C García-Sancho, R Centis, M Á Salazar-Lezama, R Pérez-Padilla
: Diabetes mellitus (DM) is a well-known risk factor for tuberculosis (TB). However, it is not known to what extent DM affects the outcome in patients with multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) treated with second-line anti-TB drugs. The objective of this study was to compare the microbiological evolution (sputum smear and culture conversion) and final outcomes of MDR/XDR-TB patients with and without DM, managed at the national TB reference centre in Mexico City...
December 30, 2016: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28043584/increased-mycobacterium-tuberculosis-antigen-induced-gene-expression-of-interferon-gamma-tumor-necrosis-factor-alpha-and-interleukin-6-in-patients-with-diabetes
#3
Kiran I Masood, Muhammad Irfan, Qamar Masood, Bushra Jamil, Shoaib Rao, Maryam Rahim, Zahra Hasan
INTRODUCTION: Pakistan ranks fifth in high tuberculosis (TB)-burden countries and seventh among countries with high prevalence rates of diabetes mellitus (DM). DM is a risk factor for TB and worsens disease outcomes. Furthermore, Mycobacterium tuberculosis (MTB) infection can induce glucose intolerance and worsen glycemic control in diabetes. Suppressor of cytokine signaling (SOCS)-1 and -3 molecules regulate cytokine signaling and are important in maintaining an immune balance. In TB, interleukin (IL)-6 upregulation induces SOCS3, which is also a negative regulator of insulin signaling...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27994782/non-caseating-granulomatous-infective-spondylitis-melioidotic-spondylitis
#4
Justin Arockiaraj, Rajiv Karthik, Veena Jeyaraj, Rohit Amritanand, Venkatesh Krishnan, Kenny Samuel David, Gabriel David Sundararaj
STUDY DESIGN: Retrospective clinical analysis. PURPOSE: To delineate the clinical presentation of melioidosis in the spine and to create awareness among healthcare professionals, particularly spine surgeons, regarding the diagnosis and treatment of melioidotic spondylitis. OVERVIEW OF LITERATURE: Melioidosis is an emerging disease, particularly in developing countries, associated with a high mortality rate. Its causative pathogen, Burkholderia pseudomallei, has been labeled as a bio-terrorism agent...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27994440/use-of-bedaquiline-and-delamanid-in-diabetes-patients-clinical-and-pharmacological-considerations
#5
REVIEW
Minhui Hu, Chunlan Zheng, Feng Gao
Antituberculosis (anti-TB) treatment may be affected by both diabetes and hypoglycemic agents in patients with these 2 comorbidities. However, data supporting this conclusion relate only to standard anti-TB therapies. Sirturo(®) (bedaquiline) and Deltyba(®) (delamanid), novel drugs for multidrug-resistant tuberculosis (MDR-TB), are recommended for diabetes patients when another effective treatment regimen cannot be provided. Currently, there are no clinical data related to the use of these agents in diabetes patients...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27986673/diabetes-mellitus-and-latent-tuberculosis-infection-a-systemic-review-and-meta-analysis
#6
Meng-Rui Lee, Ya-Ping Huang, Yu-Ting Kuo, Chen-Hao Luo, Yun-Ju Shih, Chin-Chung Shu, Jann-Yuan Wang, Jen-Chung Ko, Chong-Jen Yu, Hsien-Ho Lin
BACKGROUND: Despite the well-documented association between diabetes and active tuberculosis, evidence on the association between diabetes on latent tuberculosis infection remains limited and inconsistent. METHODS: We included observational studies that: 1) applied either the tuberculin skin test or the interferon gamma release assay for diagnosis of latent tuberculosis infection; and 2) provided adjusted effect estimate for the association between diabetes and latent tuberculosis infection...
December 16, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27955709/the-characteristics-of-patients-with-mycobacterium-tuberculosis-blood-stream-infections-in-beijing-china-a-retrospective-study
#7
Xiaoqing Liu, Sainan Bian, Yueqiu Zhang, Lifan Zhang, Qiwen Yang, Peng Wang, Yingchun Xu, Xiaochun Shi, Yao Zhang, Roy F Chemaly
BACKGROUND: Published information regarding the clinical characteristics, laboratory findings, and outcomes of patients with Mycobacterium tuberculosis (MTB) blood stream infection (BSI) is limited. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with MTB BSI. METHODS: All patients diagnosed with MTB BSI at Peking Union Medical College Hospital between January 2008 and May 2014 were identified by examining the electronic database listing results of all blood cultures...
December 12, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27935650/association-between-diabetes-mellitus-and-active-tuberculosis-in-africa-and-the-effect-of-hiv
#8
REVIEW
Sarah Lou Bailey, Helen Ayles
OBJECTIVE: To determine current evidence for the association between diabetes and active tuberculosis in Africa, and how HIV modifies, or not, any association between diabetes and active tuberculosis. METHODS: We conducted a systematic review by searching the EMBASE, Global Health and Medline databases. Studies were eligible for inclusion if they explored the association between diabetes mellitus prevalence and active tuberculosis incidence or prevalence, used a comparison group, were conducted in an African population and adjusted the analysis for at least age...
December 9, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27919230/the-association-of-hyperglycaemia-with-prevalent-tuberculosis-a-population-based-cross-sectional-study
#9
Sarah Lou Bailey, Helen Ayles, Nulda Beyers, Peter Godfrey-Faussett, Monde Muyoyeta, Elizabeth du Toit, John S Yudkin, Sian Floyd
BACKGROUND: Systematic reviews suggest that the incidence of diagnosed tuberculosis is two- to- three times higher in those with diabetes mellitus than in those without. Few studies have previously reported the association between diabetes or hyperglycaemia and the prevalence of active tuberculosis and none in a population-based study with microbiologically-defined tuberculosis. Most have instead concentrated on cases of diagnosed tuberculosis that present to health facilities. We had the opportunity to measure glycaemia alongside prevalent tuberculosis...
December 5, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27917198/diabetes-mellitus-among-tuberculosis-patients-a-cross-sectional-study-from-pakistan
#10
Zarfishan Tahir, Mansur-Ud-Din Ahmad, Abdul Majeed Akhtar, Tahir Yaqub, Muhammad Hassan Mushtaq, Hasnain Javed
BACKGROUND: The co-occurrence of diabetes mellitus (DM) and tuberculosis (TB) is largely associated with high frequency of morbidity. OBJECTIVE: To determine the prevalence of DM among TB patients and describe the socio-demographic and behavioral factors associated with TB-DM co-occurrence. METHODS: We enrolled 500 TB patients from September, 2014 to August 2015 at four major public sector hospitals of Lahore, Pakistan. A questionnaire was used to collect information regarding associated socio-demographic and behavioral factors of the patients...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27905979/diabetes-incidence-and-projections-from-prevalence-surveys-in-fiji
#11
Stephen Morrell, Sophia Lin, Isimeli Tukana, Christine Linhart, Richard Taylor, Penina Vatucawaqa, Dianna J Magliano, Paul Zimmet
BACKGROUND: Type 2 diabetes mellitus (T2DM) incidence is traditionally derived from cohort studies that are not always feasible, representative, or available. The present study estimates T2DM incidence in Fijian adults from T2DM prevalence estimates assembled from surveys of 25-64 year old adults conducted over 30 years (n = 14,288). METHODS: T2DM prevalence by five-year age group from five population-based risk factor surveys conducted over 1980-2011 were variously adjusted for urban-rural residency, ethnicity, and sex to previous censuses (1976, 1986, 1996, 2009) to improve representativeness...
November 25, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27891359/diabetes-mellitus-among-newly-diagnosed-tuberculosis-patients-in-tribal-odisha-an-exploratory-study
#12
Magna Manjareeka, Subrata Kumar Palo, Subhashisa Swain, Sandipana Pati, Sanghamitra Pati
INTRODUCTION: The association between Diabetes Mellitus (DM) and Tuberculosis (TB) poses a strong public health challenge. Tribal ethnics possess a different propensity towards infectious and haematological diseases which may influence the inter-relationship of DM and TB and thus merit separate attention. AIM: To investigate the prevalence of diabetes in newly diagnosed pulmonary TB patients of tribal ethnicity in Odisha. MATERIALS AND METHODS: A cross-sectional study was carried out over a period of 9 months at four designated TB microscopic centres in a tribal district (Malkangiri) of Odisha...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891356/attitudes-and-perceptions-of-medical-undergraduates-towards-mobile-learning-m-learning
#13
Rakesh Narayan Patil, Balaji D Almale, Mrunal Patil, Amit Gujrathi, Supriya Dhakne-Palwe, Anuradha R Patil, Shriram Gosavi
INTRODUCTION: Mobile technology is one of the latest extensions of technological innovations that can be integrated into medical education. With the aid of these devices, students learn faster outside the classroom by having quick access to the internet and easy retrieval of required health related learning resources to keep alongside of recent trend and development. In medicine practice one has to continuously update his/her medical knowledge and mobile learning will serve as a tool for self-directed learning...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27867891/bangladesh-national-guidelines-on-the-management-of-tuberculosis-and-diabetes-mellitus-co-morbidity-summary
#14
REVIEW
Mohammad Delwar Hossain, Jamal Uddin Ahmed, Muhammad Abdur Rahim, A K M Musa, Zafar Ahmed Latif
Tuberculosis (TB) and diabetes mellitus (DM) have synergetic relationship. People with diabetes are 2-3 times at higher risk of getting active TB disease. On the other hand, TB or anti-TB treatment may cause glucose intolerance. The dual disease of DM and TB is more likely to be associated with atypical disease presentation, higher probability of treatment failure and complications. In most of the health-care delivery systems of the world, DM and TB are managed separately by two vertical health-care delivery programs in spite of clear interaction between the two diseases...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27865391/modulation-of-dendritic-cell-and-monocyte-subsets-in-tuberculosis-diabetes-co-morbidity-upon-standard-tuberculosis-treatment
#15
Nathella Pavan Kumar, Kadar Moideen, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Hardy Kornfeld, Subash Babu
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis (PTB), with development of DM pandemic in countries where tuberculosis (TB) is also endemic. However, the effect of anti-TB treatment on the changes in dentritic cell (DC) and monocyte subset phenotype in TB-DM co-morbidity is not well understood. In this study, we characterized the frequency of DC and monocyte subsets in individuals with PTB with (PTB-DM) or without coincident diabetes mellitus (PTB-NDM) before, during and after completion of anti-TB treatment...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27832910/clinical-predictors-of-aminoglycoside-induced-ototoxicity-in-drug-resistant-tuberculosis-patients-on-intensive-therapy
#16
Olusola Ayodele Sogebi, Bolanle Olufunlola Adefuye, Stephen Oluwatosin Adebola, Susan Modupe Oladeji, Taiwo Olugbemiga Adedeji
OBJECTIVE: The study objectives were to determine the incidence of aminoglycoside-induced ototoxicity in institutionalized patients on intensive phase of therapy for drug-resistant Tuberculosis (DR Tb) and also to assess clinical factors which could predict the ototoxicity. METHODS: The study was a prospective analytical study among consecutive DR Tb patients who were admitted for intensive phase of therapy (of 4 months) at the DR-Tb center over a 12-month period...
November 7, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27819024/diabetes-mellitus-as-hub-for-tuberculosis-infection-a-snapshot
#17
REVIEW
Rahul Pal, Moiz A Ansari, Saif Hameed, Zeeshan Fatima
Tuberculosis (TB) still remains the thorn in the flesh of efficient therapeutics affecting one-third of global population annually. There are several factors that enhance the susceptibility to TB infections including malnutrition, smoking, and immunocompromised conditions such as AIDS. In the recent years, growing body of evidence has gained considerable prominence which suggests that Diabetes Mellitus (DM) is individual risk factor leading to complicated TB infections. In this article the authors have attempted to summarize the link of type 2 DM with TB, the mechanistic action of how DM sensitizes for developing the active TB infection from the latent infection, and problems faced during treatment followed by possible preventive measures...
2016: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/27783671/nk-cd11c-cell-crosstalk-in-diabetes-enhances-il-6-mediated-inflammation-during-mycobacterium-tuberculosis-infection
#18
Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati
In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial burden and pro- and anti-inflammatory cytokine and chemokine production in the lungs relative to those in uninfected T2DM mice and infected control mice...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27759352/kyrle-s-disease-a-rare-skin-manifestation-of-diabetes-mellitus
#19
A Pandey, Keshri S Yadav, Gaurav Singh, M Chaturvedi
Kyrle's disease is a rare skin disorder which is characterized by hyperkeratotic papules and nodules with a central keratotic plug mostly located in lower limbs. Exact etiology of Kyrle's disease is unknown, but its association has been reported sparsely with renal disorders, uremic patients on dialysis, diabetes mellitus, liver disease and paraneoplastic syndromes, tuberculosis and some fungal diseases. We report Kyrle's disease in a middle aged female suffering from diabetes mellitus with diabetic nephropathy on hemodialysis...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27740453/human-immunology-of-tuberculosis
#20
Thomas J Scriba, Anna K Coussens, Helen A Fletcher
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human infection with Mycobacterium tuberculosis is dependent on the ability of the immune response to clear or contain the infection.In cases where this fails, the bacterium replicates, disseminates within the host, and elicits a pathologic inflammatory response, and disease ensues. Clinical presentation of TB disease is remarkably heterogenous, and the disease phenotype is largely dependent on host immune status. Onward transmission of M...
October 2016: Microbiology Spectrum
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