keyword
https://read.qxmd.com/read/38532545/prediagnostic-use-of-menopausal-hormone-therapy-and-long-term-survival-of-localized-epithelial-ovarian-cancer-the-extreme-study
#21
JOURNAL ARTICLE
Alberte Hjorth Duus, Charlotte Gerd Hannibal, Louise Baandrup, Guoqiao Zheng, Michael Galanakis, Thomas Maltesen, Rasmus Hertzum-Larsen, Lina S Mørch, Susanne K Kjær
Use of menopausal hormone therapy (MHT) prior to an epithelial ovarian cancer (EOC) diagnosis has been suggested to be associated with improved survival. In a recent nationwide cohort study, we found that prediagnostic long-term MHT use, especially estrogen therapy (ET), was associated with improved long-term survival in women with nonlocalized EOC. Our aim was to investigate the influence of prediagnostic MHT use on long-term survival among women with localized EOC in the same nationwide study. Our study cohort comprised all women aged 50 years or older with an EOC diagnosis in Denmark 2000-2014 (n = 2097) identified from the Extreme study...
March 26, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38532008/sex-dimorphism-controls-dysbindin-related-cognitive-dysfunctions-in-mice-and-humans-with-the-contribution-of-comt
#22
JOURNAL ARTICLE
Federica Geraci, Roberta Passiatore, Nora Penzel, Samuele Laudani, Alessandro Bertolino, Giuseppe Blasi, Adriana C E Graziano, Gianluca C Kikidis, Ciro Mazza, Madhur Parihar, Antonio Rampino, Leonardo Sportelli, Nicolò Trevisan, Filippo Drago, Francesco Papaleo, Fabio Sambataro, Giulio Pergola, Gian Marco Leggio
Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-related differences. Genetic variants of the DTBPN1 gene associated with reduced dysbindin-1 protein (Dys) expression negatively impact cognitive functions in schizophrenia through a functional epistatic interaction with Catechol-O-methyltransferase (COMT). Dys is involved in the trafficking of dopaminergic receptors, crucial for prefrontal cortex (PFC) signaling regulation. Moreover, dopamine signaling is modulated by estrogens via inhibition of COMT expression...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38531330/err%C3%AE-1-and-aromatase-expression-in-human-placental-tissues-from-term-deliveries-of-large-for-gestational-age-lga-newborns
#23
JOURNAL ARTICLE
Marcos Abdul Palligas, Cristina Patricia Nemer, Claudia Monica Cannizzaro, Maria Sonia Baquedano, Alicia Belgorosky, Nora Saraco
INTRODUCTION: Being born either large (LGA) or small for gestational age (SGA) has been associated with an increased risk of developing metabolic syndrome in adulthood. However, the mechanism underlying this early programming remained unclear. Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor with a high expression in human placenta, particularly ERRγ1. ERRγ has been proposed to play a central role in controlling genes involved in energy metabolism...
March 26, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38531145/dhea-and-response-to-antidepressant-treatment-a-mendelian-randomization-analysis
#24
JOURNAL ARTICLE
L H Souza-Teodoro, N M Davies, H R Warren, L H S G Andrade, L A Carvalho
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation. The aim of this study is to evaluate whether higher levels of DHEA(S) are causally linked to response to antidepressants using mendelian randomization (MR). We performed a Two-sample MR analysis using data the largest publicly available GWAS of DHEA(S) levels (n = 14,846) using eight common genetic variants associated to DHEA(S) (seven single nucleotide polymorphisms and one variant rs2497306) and the largest GWAS of antidepressant response (n = 5218) using various MR methods (IVW, MR Egger, Weighted mean, weighted mode, MR-PRESSO) and single SNP analysis...
February 28, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38530728/production-of-targeted-estrone-liposomes-using-a-herringbone-micromixer
#25
JOURNAL ARTICLE
Mohamed Agam, Vinod Paul, Mohamed Abdelgawad, Ghaleb Husseini
Liposomes are spherical vesicles formed from bilayer lipid membranes that are extensively used in targeted drug delivery as nanocarriers to deliver therapeutic reagents to specific tissues and organs in the body. Recently, we have reported using estrone as an endogenous ligand on doxorubicin-encapsulating liposomes to target estrogen receptor (E.R.)-positive breast cancer cells. Estrone liposomes were synthesized using the thin-film hydration method, which is a long, arduous, and multistep process. Here, we report using a herringbone micromixer to synthesize estrone liposomes in a simple and rapid manner...
March 26, 2024: IEEE Transactions on Nanobioscience
https://read.qxmd.com/read/38529946/patterns-of-sleep-duration-and-metabolic-biomarkers-across-the-menstrual-cycle
#26
JOURNAL ARTICLE
Galit Levi Dunietz, Kerby Shedden, Xiru Lyu, Ronald D Chervin, Ana Baylin, Louise M O'Brien, Erica C Jansen, Jean Wactawski-Wende, Enrique F Schisterman, Sunni L Mumford
CONTEXT: Along the menstrual cycle, associations between inconsistent sleep duration and levels of metabolic biomarkers are uncertain and could involve fluctuations in estrogen concentrations. OBJECTIVE: To examine associations between patterns of sleep duration and metabolic biomarkers across two menstrual cycles within a cohort of premenopausal women. METHODS: The BioCycle Study was conducted in New York between 2005-2007, enrolling 259 premenopausal women over two menstrual cycles...
March 26, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38529942/determination-of-diethylstilbestrol-in-environmental-water-based-on-electrochemical-senser-modified-with-vanadium-based-metal-organic-framework-material-composite
#27
JOURNAL ARTICLE
Wanpen Zeng, Keli Wang, Yuan Zhou, Xiang Deng, Ruichao Xu, Wen Chen
In this research, the MIL-47/ACET/Nafion/GCE electrochemical senser for the determination of diethylstilbestrol (DES) was prepared with vanadyl sulfate (VOSO4 · n H2 O) and terephthalic acid (H2 BDC) as the main raw materials, compounded with acetylene black (ACET) and perfluorosulfonic acid polymer (Nafion). The compound DES belongs to the category of estrogens, and prolonged exposure to the environment can have detrimental effects on the physiological functioning of both humans and animals. Due to the strong DES enrichment performance of MIL-47(V-MOFs) with large specific surface area, in addition to the excellent conductivity and electrocatalysis of composite materials, this modified senser had good electrochemical response to DES...
March 26, 2024: Nanotechnology
https://read.qxmd.com/read/38529381/numb-cheek-syndrome-in-breast-cancer-a-case-report
#28
Zhibin Tan, Si Ying Tan
BACKGROUND: Numb cheek syndrome, a rare corollary of numb chin syndrome, is due to infra-orbital neuropathy. It can occur in association with an underlying malignancy, which can cause neuropathy by direct malignant nerve infiltration or via a paraneoplastic mechanism. Although numb cheek syndrome has been reported in association with a variety of cancers, it has previously not been reported in association with breast cancer. We report a case of left breast cancer presenting with left numb cheek syndrome...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38528611/effects-of-alendronate-on-cartilage-lesions-and-micro-architecture-deterioration-of-subchondral-bone-in-patellofemoral-osteoarthritic-ovariectomized-rats-with-patella-baja
#29
JOURNAL ARTICLE
Mingjian Bei, Zhiyuan Zheng, Yaping Xiao, Ning Liu, Xuehui Cao, Faming Tian, Liu Zhang, Xinbao Wu
BACKGROUND: Patellofemoral osteoarthritis (PFJOA) is a subtype of knee OA, which is one of the main causes of anterior knee pain. The current study found an increased prevalence of OA in postmenopausal women, called postmenopausal OA. Therefore, we designed the ovariectomized rat model of patella baja-induced PFJOA. Alendronate (ALN) inhibits osteoclast-mediated bone loss, and has been reported the favorable result of a potential intervention option of OA treatment. However, the potential effects of ALN treatment on PFJOA in the ovariectomized rat model are unknown and need further investigation prior to exploration in the clinical research setting...
March 25, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38528074/mechanistic-study-on-the-alleviation-of-postmenopausal-osteoporosis-by-lactobacillus-acidophilus-through-butyrate-mediated-inhibition-of-osteoclast-activity
#30
JOURNAL ARTICLE
Junjie Dong, Guizhao Shu, Jin Yang, Bing Wang, Lingqiang Chen, Zhiqiang Gong, Xiaofeng Zhang
In China, traditional medications for osteoporosis have significant side effects, low compliance, and high costs, making it urgent to explore new treatment options. Probiotics have demonstrated superiority in the treatment of various chronic diseases, and the reduction of bone mass in postmenopausal osteoporosis (PMOP) is closely related to the degradation and metabolism of intestinal probiotics. It is crucial to explore the role and molecular mechanisms of probiotics in alleviating PMOP through their metabolites, as well as their therapeutic effects...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527966/vaginal-estrogen-prescribing-and-cost-trends-among-medicare-part-d-beneficiaries
#31
JOURNAL ARTICLE
Alexandra L Tabakin, Wai Lee, Harvey A Winkler, Dara F Shalom
IMPORTANCE: In 2016, the American College of Obstetricians and Gynecologists issued a Committee Opinion on the safety of vaginal estrogen (VE) in estrogen-dependent breast cancer patients. Since that time, prescribing trends of VE have not been studied. OBJECTIVE: Our objective was to analyze expenditure and prescribing trends of VE from 2016 to 2020 for Medicare Part D beneficiaries. STUDY DESIGN: In this retrospective review, we queried the Medicare Part D Spending and Prescriber Datasets from 2016 to 2020 to identify claims for VE...
March 26, 2024: Urogynecology (Phila)
https://read.qxmd.com/read/38527894/comparative-evaluation-of-spe-methods-for-biotoxicity-assessment-of-water-and-wastewater-linkage-between-chemical-extracting-efficiency-and-biotoxicity-outcome
#32
JOURNAL ARTICLE
Jiawei Zhou, Shihao Wang, Xiwei He, Hongqiang Ren, Xu-Xiang Zhang
Biotoxicity assessment results of environmental waters largely depend on the sample extraction protocols that enrich pollutants to meet the effect-trigger thresholds of bioassays. However, more chemical mixture does not necessarily translate to higher combined biotoxicity. Thus, there is a need to establish the link between chemical extracting efficiency and biotoxicity outcome to standardize extraction methods for biotoxicity assessment of environmental waters. This study compares the performance of five different extraction phases in solid phase extraction (SPE), namely HLB, HLB+Coconut, C18 cartridge, C18 disk and Strata-X, and evaluated their chemical extracting efficiencies and biotoxicity outcomes...
August 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38527850/disruption-of-thyroid-hormone-receptor-thrab-leads-to-female-infertility-in-zebrafish
#33
JOURNAL ARTICLE
Nana Ai, Cho Rong Han, Hui Zhao, Sheue-Yann Cheng, Wei Ge
Thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are vital for development, growth, and metabolism. Thyroid dysfunction can also cause problems in fertility, suggesting involvement of THs in reproduction. In zebrafish, there exist two forms of TH receptor alpha gene (THRα: thraa and thrab). Disruption of these genes by CRISPR/Cas9 showed no reproductive irregularities in thraa mutant; however, inactivation of thrab gene resulted in female infertility. Although young female mutants (thrabm/m) showed normal ovarian development and folliculogenesis before sexual maturation, they failed to release eggs during oviposition after sexual maturation...
March 25, 2024: Endocrinology
https://read.qxmd.com/read/38527495/long-term-multimodal-recording-reveals-epigenetic-adaptation-routes-in-dormant-breast-cancer-cells
#34
JOURNAL ARTICLE
Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani
UNLABELLED: Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late relapse patients and longitudinally profiled a rare cohort treated with long-term neoadjuvant ETs until progression...
March 21, 2024: Cancer Discovery
https://read.qxmd.com/read/38526769/estrogen-receptor-status-determines-differential-regulation-of-%C3%AE-1-and-%C3%AE-2-adrenoceptor-mediated-cell-survival-angiogenesis-and-intracellular-signaling-responses-in-breast-cancer-cell-lines
#35
JOURNAL ARTICLE
Hannah P Priyanka, Uday P Pratap, Rahul S Nair, Ramasamy Vasantharekha, Srinivasan ThyagaRajan
Psychosocial stress promotes cancer pathogenesis involving angiogenesis through alterations in neuroendocrine-immune functions that may involve adrenoceptor (AR)-dependent signaling mechanisms in the brain, lymphoid organs, and cancerous cells. Various concentrations of α1 - and α2 - AR-specific agonists and antagonists were incubated in vitro with estrogen receptor-positive (ER +) MCF-7, and ER (-) MDA MB-231 cells to examine the secretions of VEGF-A, VEGF-C, and nitric oxide (NO), and expression of signaling molecules- p-ERK, p-CREB, and p-Akt on the proliferation of breast cancer cell lines...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38526210/ethynylestradiol-feminizes-gene-expression-partly-in-testis-developing-as-ovotestis-and-disrupts-asymmetric-m%C3%A3-llerian-duct-development-by-eliminating-asymmetric-gene-expression-in-japanese-quail-embryos
#36
JOURNAL ARTICLE
Natsuko Abe, Akari Sakiyama, Maho Suzuki, Tin-Tin Win-Shwe, Takehiro Suzuki, Takaharu Kawashima, Shinji Tsukahara
In avian embryos, xenoestrogens induce abnormalities in reproductive organs, particularly the testes and Müllerian ducts (MDs). However, the molecular mechanisms remain poorly understood. We investigated the effects of ethynylestradiol (EE2) exposure on gene expression associated with reproductive organ development in Japanese quail embryos. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis revealed that the left testis containing ovary-like tissues following EE2 exposure highly expressed the genes for steroidogenic enzymes (P450scc, P45017α, lyase, and 3β-HSD) and estrogen receptor-β, compared to the right testis...
March 25, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38525715/breast-cancer-risk-factors-among-women-with-solid-breast-lesions
#37
JOURNAL ARTICLE
Ivana Eremici, Andreea Borlea, Catalin Dumitru, Dana Stoian
BACKGROUND: Breast cancer is the most frequent malignancy in women worldwide and one of the most curable cancers if diagnosed at an early stage. Female patients presenting solid breast lesions are greatly predisposed to breast cancer development, and as such, effective screening of high-risk patients is valuable in early-stage breast cancer detection. OBJECTIVES: The aim of our study was to identify the most relevant demographic, reproductive and lifestyle risk factors for breast cancer among women with solid breast lesions living in western Romania, namely the urban region consisting of Timisoara and the rural surrounding regions...
March 18, 2024: Clinics and Practice
https://read.qxmd.com/read/38525418/clinical-characteristics-and-prognostic-factors-of-male-breast-cancer-in-china
#38
JOURNAL ARTICLE
Han Lei, Baojie Hua, Yingying Mao, Wei Cui, Caiping Mao, Shaoxue Yang, Jiayu Li
PURPOSE: This study aimed to explore the clinical characteristics of male breast cancer (MBC) patients and the factors influencing their prognosis. METHODS: We conducted a retrospective case series analysis of 117 MBC cases who were treated at Zhejiang Cancer Hospital from 2009 to 2022. Cox proportional hazard model was used to identify prognostic factors of MBC. Nomogram was constructed based on these factors, which was further evaluated by C-index and calibration curves...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38525416/benign-brenner-tumor-of-the-ovary-two-dimensional-and-contrast-enhanced-ultrasound-features-a-retrospective-study-from-a-single-center
#39
JOURNAL ARTICLE
Mei Chen, Shusheng Liao, Yong Cao, Meiya Mao, Xiupeng Jia, Shengmin Zhang, Youfeng Xu
OBJECTIVE: Benign Brenner tumor (BBT) is a rare ovarian tumor, and there are few discrete reports about its manifestation in an ultrasound. This study sought to investigate the two-dimensional (2D) and contrast-enhanced ultrasound (CEUS) features of this entity. METHODS: This is a retrospective single-center study. The clinical manifestations, laboratory examination, and ultrasound data of 25 female patients with BBT were confirmed by pathology when they underwent 2D and/or CEUS examination at Ningbo First Hospital from January 2012 to June 2023...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38524710/knee-laxities-changes-with-sex-steroids-throughout-the-menstrual-cycle-phases-in-athlete-and-non-athlete-females
#40
JOURNAL ARTICLE
Firouzeh Dehghan, Rahman Soori, Ashril Yusof
Objective:  Our study investigated changes of knee laxities in athletes and non-athletes females and relationship between knee laxity and sex-steroid at menstrual cycle phases. Methods:  Forty six healthy females, twenty four athletes and twenty two non-athletes not on hormone contraceptive pills, had no previous knee injuries and with regular menstrual cycles for 3 consecutive months, participated in the study. Medial and lateral knee laxities were determined by varus-valgus tests at follicular, ovulatory and luteal phases...
February 2024: Revista Brasileira de Ortopedia
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