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Cancer of prostate

Gati K Panigrahi, Prakash P Praharaj, Taylor C Peak, Jessica Long, Ravi Singh, Johng S Rhim, Zakaria Y Abd Elmageed, Gagan Deep
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 24, 2018: Scientific Reports
Michael R McDevitt, Daniel L J Thorek, Takeshi Hashimoto, Tatsuo Gondo, Darren R Veach, Sai Kiran Sharma, Teja Muralidhar Kalidindi, Diane S Abou, Philip A Watson, Bradley J Beattie, Oskar Vilhemsson Timmermand, Sven-Erik Strand, Jason S Lewis, Peter T Scardino, Howard I Scher, Hans Lilja, Steven M Larson, David Ulmert
Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the hormone-DNA repair circuit to enable molecularly-specific alpha particle irradiation of PCa. Alpha-particle irradiation of PCa is prompted by molecularly specific-targeting and internalization of the humanized monoclonal antibody hu11B6 targeting hK2 and further accelerated by inherent DNA-repair that up-regulate hK2 (KLK2) expression in vivo...
April 24, 2018: Nature Communications
Hai Huang, Chao Wang, Fei Liu, Hui-Zhen Li, Guang Peng, Xu Gao, Ke-Qin Dong, Hong-Ru Wang, De-Pei Kong, Min Qu, Li-He Dai, Kai-Jian Wang, Zhe Zhou, Jun Yang, Ze-Yu Yang, Yan-Qiong Cheng, Qin-Qin Tian, Dan Liu, Chuan-Liang Xu, Dan-Feng Xu, Xin-Gang Cui, Ying-Hao Sun
PURPOSE: Cancer stem-like cells (CSCs) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. Since CSCs depend on their specific niche, including tumor-associated macrophages (TAMs), elucidating the network between CSCs and TAMs may help to effectively inhibit the progression and ADT resistance of prostate cancer. EXPERIMENTAL DESIGN: The underlying intracellular mechanism that sustains the stem-like characteristics of CSCs in prostate cancer was assessed via RNA-seq, co-IP, ChIP and other assays...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
James Dewitt, Benjamin Capistrant, Nidhi Kohli, B R Simon Rosser, Darryl Mitteldorf, Enyinnaya Merengwa, William West
BACKGROUND: While deduplication and cross-validation protocols have been recommended for large Web-based studies, protocols for survey response validation of smaller studies have not been published. OBJECTIVE: This paper reports the challenges of survey validation inherent in a small Web-based health survey research. METHODS: The subject population was North American, gay and bisexual, prostate cancer survivors, who represent an under-researched, hidden, difficult-to-recruit, minority-within-a-minority population...
April 24, 2018: JMIR Research Protocols
Afifa Masood, Nadeem Iqbal, Durre Shohab, Aisha Hasan, Sibgha Aimon, Ujala Mahmood, Saeed Akhter
Prostate cancer (PCa) is one of the leading cancers in older males. The aim of this study was to evaluate the clinico-pathological characteristics of prostate cancer and rate of detection of prostate cancer by DRE (digital rectal exam) in patients presenting to a tertiary care private sector hospital in Islamabad, and determine the awareness about PCa in these patients. There were 226 patients who presented from December 2009 to December 2015 having mean age of 68.63 ±8.76 years and median Prostate Specific Antigen (PSA) value of 19...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Y C Liang, Y P Wu, H Cai, S H Cheng, Y Wei, X Y Xue, Q S Zheng, J B Huang, Y Z Lin, N Xu
Objective: To determine the influence of urethral fibrosis on the recovery of urinary continence after laparoscopic radical prostatectomy. Method: A retrospective study of 203 patients from January 2010 to January 2014 who were underwent laparoscopic radical prostatectomy for prostate cancer in the First Affiliated Hospital of Fujian Medical University. The patients were divided into 2 groups according to preoperative T2-weighted magnetic resonance imaging of fibrosis status of the urethral wall and periurethral tissue...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Shyh-Han Tan, Gyorgy Petrovics, Shiv Srivastava
Prostate cancer (CaP) is the most commonly diagnosed non-cutaneous cancer and the second leading cause of male cancer deaths in the United States. Among African American (AA) men, CaP is the most prevalent malignancy, with disproportionately higher incidence and mortality rates. Even after discounting the influence of socioeconomic factors, the effect of molecular and genetic factors on racial disparity of CaP is evident. Earlier studies on the molecular basis for CaP disparity have focused on the influence of heritable mutations and single-nucleotide polymorphisms (SNPs)...
April 22, 2018: International Journal of Molecular Sciences
Yu Wang, Xiaorong Jiang, Shasha Wang, Haixia Yu, Tingtin Zhang, Shuan Xu, Wenlong Li, Ellen He, Sven Skog
BACKGROUND: People with biomarkers above cut-off values normally have higher risk to develop pre-malignancies and malignancies. OBJECTIVE: Here we investigate if serological TK1 protein (STK1p), AFP, CEA and PSA below cut-off values predict development of pre-cancer. METHODS: The mean values and the concentration distribution of STK1p, AFP, CEA and PSA were determined in a cohort of 56,178 persons participating a health screening group, consist of people with non-tumor diseases, pre-malignancy and diseases associated with the risk process of malignancy...
April 6, 2018: Cancer Biomarkers: Section A of Disease Markers
Wei-Yu Lin, Vincent Chin-Hung Chen, Wei-Che Chiu, Samantha J Yim, Peter T Ho, Roger S McIntyre, Mong-Liang Lu, Shui-I Wu
BACKGROUND: We aimed to evaluate the association between antidepressant and prostate cancer by comparing exposures to antidepressants between those with and without prostate cancer. METHODS: A nationwide insurance claims database was used to identify our case subjects. Age- and gender-matched controls were selected at a 1:5 ratio. Conditional logistic regression model was used. RESULTS: 11,515 patients with prostate cancer were identified and matched with 55,373 controls...
February 2018: Journal of Affective Disorders
Xu Zhou, Long Yang, Xiaoping Tan, Genfu Zhao, Xiaoguang Xie, Guanben Du
Prostate specific antigen (PSA) is the most significant biomarker for the screening of prostate cancer in human serum. However, most methods for the detection of PSA often require major laboratories, precisely analytical instruments and complicated operations. Currently, the design and development of satisfying electrochemical biosensors based on biomimetic materials (e.g. synthetic receptors) and nanotechnology is highly desired. Thus, we focused on the combination of molecular recognition and versatile nanomaterials in electrochemical devices for advancing their analytical performance and robustness...
April 18, 2018: Biosensors & Bioelectronics
Dharmender Malik, Rajender Kumar, Bhagwant Rai Mittal, Harmandeep Singh, Anish Bhattacharya, Shrawan Kumar Singh
PET/CT with Ga-labeled prostate-specific membrane antigen (PSMA) is increasingly recognized as the best imaging modality for disease staging and detection of recurrent prostate cancer. Despite its name, PSMA expression has been reported in a number of nonprostatic benign and malignant pathologies. Apparently, angioneogenesis is the mechanism attributed to increased Ga-PSMA uptake at these sites. Here we illustrate the utility of Ga-PSMA in 5 nonprostatic malignancies that could open up new possibilities for diagnostics and theranostic concepts with PSMA labeled radioligands in nonprostate tumor entities...
April 23, 2018: Clinical Nuclear Medicine
Dixon T S Woon, Thenappan Chandrasekar, Lorne Aaron, Naveen S Basappa, Kim N Chi, Henry J Conter, Brita Danielson, Sebastien J Hotte, Shawn Malone, Fred Saad, Bobby Shayegan, Laura Park-Wyllie, Robert J Hamilton
INTRODUCTION: Treatment using abiraterone acetate, enzalutamide, cabazitaxel, and radium-223 (Ra-223) improve overall survival (OS) and quality of life for patients with metastatic castrate-resistant prostate cancer (mCRPC). Despite their proven benefits, access to these therapies is not equal across Canada. METHODS: We describe provincial differences in access to approved mCRPC therapies. Data sources include the pan-Canadian Oncology Drug Review database, provincial cancer care resources, and correspondence with pharmaceutical companies...
April 12, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Ariadna Garcia-Saenz, Alejandro Sánchez de Miguel, Ana Espinosa, Antonia Valentin, Núria Aragonés, Javier Llorca, Pilar Amiano, Vicente Martín Sánchez, Marcela Guevara, Rocío Capelo, Adonina Tardón, Rosana Peiró-Perez, José Juan Jiménez-Moleón, Aina Roca-Barceló, Beatriz Pérez-Gómez, Trinidad Dierssen-Sotos, Tania Fernández-Villa, Conchi Moreno-Iribas, Victor Moreno, Javier García-Pérez, Gemma Castaño-Vinyals, Marina Pollán, Martin Aubé, Manolis Kogevinas
BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013...
April 23, 2018: Environmental Health Perspectives
Mark Emberton
No abstract text is available yet for this article.
May 2018: BJU International
Veronique Nogueira, Krushna Chandra Patra, Nissim Hay
Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of prostate cancer displaying hyperactive Akt. PTEN-deficient prostate cancer cells that display hyperactivated Akt have high intracellular reactive oxygen species (ROS) levels, which are due, in part, to Akt-dependent increase of oxidative phosphorylation. High intracellular ROS levels selectively sensitize cells displaying hyperactive Akt to ROS-induced cell death enabling a therapeutic strategy combining a ROS inducer and rapamycin in PTEN-deficient prostate tumors in mouse models...
April 24, 2018: ELife
Andrea Mancini, Alessandro Colapietro, Simona Pompili, Andrea Del Fattore, Simona Delle Monache, Leda Assunta Biordi, Adriano Angelucci, Vincenzo Mattei, Chris Liang, Giovanni Luca Gravina, Claudio Festuccia
Morbidity in advanced prostate cancer patients is largely associated with bone metastatic events. The development of novel therapeutic strategies is imperative in order to effectively treat this incurable stage of the malignancy. In this context, Akt signaling pathway represents a promising therapeutic target able to counteract biochemical recurrence and metastatic progression in prostate cancer. We explored the therapeutic potential of a novel dual PI3 K/mTOR inhibitor, X480, to inhibit tumor growth and bone colonization using different in vivo prostate cancer models including the subcutaneous injection of aggressive and bone metastatic (PC3) and non-bone metastatic (22rv1) cell lines and preclinical models known to generate bone lesions...
April 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Paolo Boffetta, Vimi Desai
No systematic reviews are available on data from humans on cancer risk from exposure to permethrin, a widely used insecticide for which some animal studies have reported positive findings based on mechanisms that may not be relevant to humans. We identified potentially relevant articles through a search of electronic databases which included all studies of pesticide exposure and human cancer. A total of 18 articles were selected, including six identified from the list of references of other articles. Most articles were based on analyzes of the Agriculture Health Study (AHS); they provided no evidence of an increased risk of cancers of colon, rectum, pancreas, lung, melanoma, female breast, prostate, urinary bladder, as well as non-Hodgkin lymphoma (including its main subtypes), and leukemia...
April 24, 2018: Critical Reviews in Toxicology
Steven Lacy, Bei Yang, Jace Nielsen, Dale Miles, Linh Nguyen, Matt Hutmacher
PURPOSE: An integrated population pharmacokinetic (popPK) model was developed to describe the pharmacokinetics (PK) of tyrosine kinase inhibitor cabozantinib in healthy volunteers (HVs) and patients with various cancer types and to identify any differences in cabozantinib PK across these populations. METHODS: Plasma concentration data used to develop the popPK model were obtained from nine clinical trials (8072 concentrations from 1534 HVs or patients) of cabozantinib in HVs and patients with renal cell carcinoma (RCC), medullary thyroid carcinoma (MTC), glioblastoma multiforme, castration-resistant prostate cancer, or other advanced malignancies...
April 23, 2018: Cancer Chemotherapy and Pharmacology
Berardino De Bari, Rosario Mazzola, Dario Aiello, Sergio Fersino, Fabiana Gregucci, Pierpaolo Alongi, Maurizio Nicodemo, Stefano Cavalleri, Matteo Salgarello, Filippo Alongi
AIM: To evaluate the impact of gallium68 PSMA-11 (HBED-CC)-PET/CT on decision-making strategy of patients with relapsing prostate cancer (PC) presenting a second biochemical relapse after radical prostatectomy (RP) and salvage RT or salvage androgen deprivation therapy (ADT). MATERIALS AND METHODS: 40 patients were retrospectively analyzed. All of them had received prostatectomy. Thirteen out of 40 were addressed to gallium68 PSMA-11 (HBED-CC)-PET/CT for a biochemical relapse after RP, 14/40 after a salvage RT and 13/40 after salvage or adjuvant ADT...
April 23, 2018: La Radiologia Medica
Rajeev Jyoti, Tarun Pankaj Jain, Hodo Haxhimolla, Heath Liddell, Sean Edward Barrett
Introduction: The purpose was to investigate the usefulness of ADCratio on Diffusion MRI to discriminate between benign and malignant lesions of Prostate. Methods: Images of patients who underwent in-gantry MRI guided prostate lesion biopsy were retrospectively analyzed. Prostate Cancers with 20% or more Gleason score (GS) pattern 3 + 3 = 6 in each core or any volume of higher Gleason score pattern were included. ADCratio was calculated by two reviewers for each lesion...
2018: European Journal of Radiology Open
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