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https://www.readbyqxmd.com/read/29224236/prognostic-factors-of-prostate-cancer-mortality-in-a-finnish-randomized-screening-trial
#1
Subas Neupane, Ewout Steyerberg, Jani Raitanen, Kirsi Talala, Juho Pylväläinen, Kimmo Taari, Teuvo Lj Tammela, Anssi Auvinen
OBJECTIVES: To identify the prognostic factors of prostate cancer death among patients enrolled in a Finnish prostate cancer screening trial. METHODS: Data on TNM stage, Gleason score, serum prostate-specific antigen at diagnosis, comorbidity and primary treatment were collected from medical records, as well as date and cause of death from Statistics Finland. Four prognostic risk groups were defined based on TNM stage, Gleason score and prostate-specific antigen at diagnosis...
December 10, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29224177/thinking-about-one-s-own-death-after-prostate-cancer-diagnosis
#2
Thordis K Thorsteinsdottir, Heiddis Valdimarsdottir, Johan Stranne, Ulrica Wilderäng, Eva Haglind, Gunnar Steineck
BACKGROUND: Prostate-cancer diagnosis increases the risk for psychiatric morbidity and suicide. Thoughts about one's own death could indicate need for psychiatric care among men with localized prostate cancer. We studied the prevalence and predictors of thoughts about own death among men with prostate cancer. METHODS: Of the 3930 men in the prospective, multi-centre LAPPRO-trial, having radical prostatectomy, 3154 (80%) answered two study-specific questionnaires, before and three months after surgery...
December 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29224174/cost-effectiveness-of-treatments-for-the-management-of-bone-metastases-a-systematic-literature-review
#3
REVIEW
Lazaros Andronis, Ilias Goranitis, Sue Bayliss, Rui Duarte
BACKGROUND: Metastatic cancers occur when cancer cells break away from the primary tumour. One of the most common sites of metastasis is the bone, with several therapeutic options currently available for managing bone metastases. In a resource-constrained environment, policy makers and practitioners need to know which options are cost effective. OBJECTIVE: The aim of this systematic review was to review and appraise published economic evaluations on treatments for the management of bone metastases...
December 9, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29224109/testosterone-therapy-and-glucose-homeostasis-in-men-with-testosterone-deficiency-hypogonadism
#4
Farid Saad
Since the early 1990s, it has been recognized that testosterone (T) levels are lower in men with type 2 diabetes mellitus (T2DM) compared with nondiabetic men (controls). Hypogonadism has been reported in approximately 50% of men with T2DM with robust correlations with measures of obesity, such as waist circumference and body mass index (BMI). In longitudinal studies, hypogonadism has been identified as a predictor of incident T2DM. Experimental withdrawal of T led to acute decreased insulin sensitivity, which can be reversed by normalization of T concentrations...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223493/comparison-of-adjuvant-radiation-therapy-before-or-after-artificial-urinary-sphincter-placement-a-multi-institutional-retrospective-analysis
#5
Kenneth J DeLay, Nora M Haney, Jason Chiang, Carrie Stewart, Faysal A Yafi, Kenneth Angermeier, Hadley Wood, Timothy Boone, Alex G Kavanagh, Matthew Gretzer, Stuart Boyd, Jeffrey C Loh-Doyle, Wayne J G Hellstrom
OBJECTIVE: To determine if the timing of radiation therapy on artificial urinary sphincter (AUS) impacts complication rates, revision rates, and number of pads per day after placement. METHODS: A retrospective review was conducted of men with prostate cancer who underwent AUS placement and radiation therapy between 1987 and 2016. RESULTS: Of 306 men, 292 (95.4%) received radiation before AUS placement (Group 1) and 14 (4.6%) received radiation after AUS placement (Group 2)...
December 6, 2017: Urology
https://www.readbyqxmd.com/read/29223469/oncological-and-functional-outcomes-of-elderly-men-treated-with-hifu-vs-minimally-invasive-radical-prostatectomy-a-propensity-score-analysis
#6
Paolo Capogrosso, Eric Barret, Rafael Sanchez-Salas, Igor Nunes-Silva, François Rozet, Marc Galiano, Eugenio Ventimiglia, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Xavier Cathelineau
AIM: To assess outcomes of whole gland high-intensity focused ultrasound (HIFU) as compared with minimally-invasive radical prostatectomy (MIRP) in elderly patients. MATERIALS & METHODS: Patients aged ≥70 years with, cT1-cT2 disease, biopsy Gleason score (GS) 3 + 3 or 3 + 4 and preoperative PSA ≤10 ng/mL were submitted to either whole-gland HIFU or MIRP. Propensity-score matching analysis was performed to ensure the baseline equivalence of groups. Follow-up visits were routinely performed assessing PSA and urinary function according to the International Continence Score (ICS) and the International Prostatic Symptoms Score (IPSS) questionnaires...
December 1, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29223415/-psychological-impact-of-prostate-cancer-on-patients-receiving-a-6-month-androgen-deprivation-therapy
#7
A de la Taille, S Mardoyan, A Lafaye
BACKGROUND: Prostate cancer (PCa) is often associated with psychopathological symptoms such as anxiety. This study evaluated the effects of the luteinizing hormone-releasing hormone agonist therapy leuprorelin acetate (LA) on anxiety and quality of life (QoL) over time in men with PCa. METHODS: This observational, non interventional, multicenter study was conducted in France. Patients with PCa eligible for therapy with a 6-month LA depot were enrolled. Patients completed questionnaires assessing anxiety (memorial anxiety scale for prostate cancer [MAX-PC] ; state trait anxiety inventory [STAI]) and QoL (medical outcomes study 12-item short-form health survey [SF-12] physical summary component [PCS] and mental component summary [MSCS] subscales) at baseline and 6 months after 6-month LA depot administration...
December 6, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29223389/a-multi-institutional-prospective-trial-in-the-veterans-affairs-health-system-confirms-the-4kscore-maintains-its-predictive-value-among-african-american-men
#8
Sanoj Punnen, Stephen J Freedland, Thomas J Polascik, Stacy Loeb, Michael C Risk, Stephen Savage, Sharad C Mathur, Edward Uchio, Yan Dong, Jonathan L Silberstein
PURPOSE: The 4Kscore test accurately detects aggressive prostate cancer and reduces unnecessary biopsies, however, its performance in African American (AA) men is unknown. This study assessed the performance of the 4Kscore test in a cohort of men with a large AA representation. MATERIALS AND METHODS: Men referred for a biopsy of the prostate at eight Veteran's Affairs Medical centers were prospectively enrolled. All men underwent phlebotomy for 4Kscore test assessment prior to biopsy of the prostate...
December 6, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29223029/design-synthesis-and-evaluation-of-novel-n-hydroxybenzamides-n-hydroxypropenamides-incorporating-quinazolin-4-3h-ones-as-histone-deacetylase-inhibitors-and-antitumor-agents
#9
Doan Thanh Hieu, Duong Tien Anh, Nguyen Minh Tuan, Pham-The Hai, Le-Thi-Thu Huong, Jisung Kim, Jong Soon Kang, Tran Khac Vu, Phan Thi Phuong Dung, Sang-Bae Han, Nguyen-Hai Nam, Nguyen-Dang Hoa
In our search for novel small molecules targeting histone deacetylases, we have designed and synthesized several series of novel N-hydroxybenzamides/N-hydroxypropenamides incorporating quinazolin-4(3H)-ones (4a-h, 8a-d, 10a-d). Biological evaluation showed that these hydroxamic acids were generally cytotoxic against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung cancer). It was found that the N-hydroxypropenamides (10a-d) were the most potent, both in term of HDAC inhibition and cytotoxicity...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29222925/quantification-of-photonic-localization-properties-of-targeted-nuclear-mass-density-variations-application-in-cancer-stage-detection
#10
Peeyush Sahay, Aditya Ganju, Huda M Almabadi, Hemendra M Ghimire, Murali M Yallapu, Omar Skalli, Meena Jaggi, Subhash C Chauhan, Prabhakar Pradhan
Light localization is a phenomenon which arises due to the interference effects of light waves inside a disordered optical medium. Quantification of degree light localization in optical media is widely used for characterizing degree of structural disorder in that media. Recently, this light localization approach was extended to analyze structural changes in biological cell like heterogeneous optical media, with potential application in cancer diagnostics. Confocal fluorescence microscopy was used to construct 'optical lattices', which represents 2D refractive index map corresponding to the spatial mass density distribution of a selected molecule inside the cell...
December 9, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29222833/association-between-measures-of-treatment-quality-and-disease-progression-in-prostate-cancer-radiotherapy-an-exploratory-analysis-from-the-trog-03-04-radar-trial
#11
Marco Marcello, Martin A Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, Max Bulsara, Rachel Kearvell, David J Joseph, James W Denham
INTRODUCTION: Quality assurance methods are incorporated into multicentre radiotherapy clinical trials for ensuring consistent application of trial protocol and quantifying treatment uncertainties. The study's purpose was to determine whether post-treatment disease progression is associated with measures of the quality of radiotherapy treatment. METHODS: The TROG 03.04 RADAR trial tested the impact of androgen deprivation on prostate cancer patients receiving dose-escalated external beam radiation therapy...
December 8, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29222705/tai-chi-and-qigong-for-cancer-related-symptoms-and-quality-of-life-a-systematic-review-and-meta-analysis
#12
REVIEW
Peter M Wayne, M S Lee, J Novakowski, K Osypiuk, J Ligibel, L E Carlson, R Song
PURPOSE: This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind-body exercises on symptoms and quality of life (QOL) in cancer survivors. METHODS: A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges' g) and publication bias for randomized controlled trials (RCTs)...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29222677/diagnostic-evaluation-of-magnetization-transfer-and-diffusion-kurtosis-imaging-for-prostate-cancer-detection-in-a-re-biopsy-population
#13
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29222597/incongruence-in-treatment-decision-making-is-associated-with-lower-health-related-quality-of-life-among-prostate-cancer-survivors-results-from-the-picture-study
#14
Frances J Drummond, Anna T Gavin, Linda Sharp
PURPOSE: We investigated associations between treatment decision making (TDM) and global health-related-quality-of-life (gHRQoL) among prostate cancer (PCa) survivors. METHODS: Postal questionnaires were sent to 6559 PCa survivors 2-18 years post-diagnosis, identified through population-based cancer registries in Ireland. The Control Preference Scale was used to investigate respondents' 'actual' and 'preferred' role in TDM. The TDM experience was considered 'congruent' when actual and preferred roles matched and 'incongruent' otherwise...
December 8, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29222595/-prostate-cancer-risk-calculator-mobile-applications-apps-a-systematic-review-and-scoring-using-the-validated-user-version-of-the-mobile-application-rating-scale-umars
#15
Ahmed Adam, Julian C Hellig, Marlon Perera, Damien Bolton, Nathan Lawrentschuk
PURPOSE: The use of mobile phone applications (Apps) has modernised the conventional practice of medicine. The diagnostic ability of the current Apps in prostate specific antigen monitoring, and its diagnostic ability within prostate cancer (PCa) risk calculators have not yet been appraised. We aimed to review, rate and assess the everyday functionality, and utility of all the currently available PCa risk calculator Apps. METHODS: A systematic search on iTunes, Google Play Store, Blackberry World and Windows Apps Store, was performed on 23/11/2017, using the search term 'prostate cancer risk calculator'...
December 8, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29222530/seizure-rates-in-enzalutamide-treated-men-with-metastatic-castration-resistant-prostate-cancer-and-risk-of-seizure-the-upward-study
#16
Susan Slovin, William Clark, Joan Carles, Andrew Krivoshik, Jung Wook Park, Fong Wang, Daniel George
Importance: The androgen receptor inhibitor enzalutamide prolongs survival in men with metastatic castration-resistant prostate cancer (mCRPC). In controlled clinical studies, 0.5% (10 of 2051) of patients experienced seizure, but patients with a history of or risk factors for seizure were excluded. Men with mCRPC and seizure risk factors have an estimated seizure rate of 2.8 per 100 patient-years without enzalutamide exposure. Objective: To assess seizure incidence in patients with seizure risk factors who were receiving enzalutamide for mCRPC...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29222347/pioglitazone-inhibits-periprostatic-white-adipose-tissue-inflammation-in-obese-mice
#17
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi K Zhou, Hanhan Wang, Domenick J Falcone, Dilip D Giri, Andrew J Dannenberg
Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and poor prognosis for PC patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade PC. It's possible, therefore, that agents that suppress periprostatic WAT inflammation will alter the development or progression of PC. Pioglitazone, a ligand of PPARγ is used to treat diabetes and possesses anti-inflammatory properties...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29222198/higher-muscle-strength-is-associated-with-prolonged-survival-in-older-patients-with-advanced-cancer
#18
Kathelijn Sophie Versteeg, Susanne Blauwhoff-Buskermolen, Laurien M Buffart, Marian A E de van der Schueren, Jacqueline A E Langius, Henk M W Verheul, Andrea B Maier, Inge R Konings
BACKGROUND: Identifying predictors of treatment toxicity and overall survival (OS) is important for selecting patients who will benefit from chemotherapy. In younger patients with cancer, muscle mass and radiodensity are associated with treatment toxicity and OS. In this study, we investigated whether muscle mass, radiodensity, and strength were associated with treatment toxicity and OS in patients with advanced cancer aged 60 years or older. MATERIALS AND METHODS: Before starting palliative chemotherapy, muscle mass and radiodensity were assessed using computed tomography scans and muscle strength was assessed using a hydraulic hand grip dynamometer...
December 8, 2017: Oncologist
https://www.readbyqxmd.com/read/29222106/psma-brings-new-flavors-to-pi3k-signaling-a-role-for-glutamate-in-prostate-cancer
#19
Lavinia Palamiuc, Brooke M Emerling
In this issue of JEM, Kaittanis et al. (https://doi.org/10.1084/jem.20171052) report a new signaling role for prostate-specific membrane antigen (PSMA), providing a mechanistic link between two major oncogenic pathways, as well as promising therapeutic implications for the diagnosis and treatment of prostate cancer.
December 8, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29221985/hotair-mediated-reciprocal-regulation-of-ezh2-and-dnmt1-contribute-to-polyphyllin-i-inhibited-growth-of-castration-resistant-prostate-cancer-cells-in-vitro-and-in-vivo
#20
SongTao Xiang, PeiLiang Zou, Qing Tang, Fang Zheng, JingJing Wu, ZhiQiang Chen, Swei Sunny Hann
BACKGROUND: Polyphyllin I (PPI), one of the steroidal saponins in paris polyphylla, has been reported to exhibit antitumor effects. However, the detailed molecular mechanism underlying this has not been elucidated. METHODS: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and Flow cytometry assays, respectively. Cell invasion and migration were examined by Transwell invasion and wound healing assays...
December 5, 2017: Biochimica et Biophysica Acta
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