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JOURNAL ARTICLE
Dipti Baskar, Seena Vengalil, Saraswati Nashi, Deepak Menon, Nandeesh Bevinahalli N, Aneesha Thomas, Mainak Bardhan, Sai Bhargava Sanka, Nisha Manjunath, Atchayaram Nalini
Tangier disease is an autosomal recessive multisystem metabolic disorder with neuromuscular manifestations including peripheral neuropathy such as multifocal mononeuropathy or pseudosyringomyelia patterns. We report a novel phenotype of Tangier disease with predominant anterior horn cell involvement. A 16-year-old adolescent girl born to consanguineous parents had a 1-year history of hip girdle weakness with waddling gait and progressive atrophy of the right leg. She had orange tonsils, prominent lingual tonsils, soft skin, distal joint laxity, diffuse hypotonia with asymmetric wasting of legs, proximodistal moderate weakness in lower limbs, and tendon reflexes were hypoactive...
September 1, 2023: Journal of Clinical Neuromuscular Disease
#22
JOURNAL ARTICLE
Abdullah Abdulhamid Altaweel, Nashi K Alqahtani, Abdullah J Alasoom, Dalya Ramzi Alsulaiman, Shahzeen Fatima Hussaini, Hany Ezzat Khalil
The serious adverse effects, such as nephrotoxicity, limit the clinical utility of anticancer doxorubicin (DOX) drug. Cichorium endivia L. is reputed to show antioxidive effectiveness. The present investigation was conducted to explore the nephroprotective potential of crude methanol extract of Cichorium endivia (CECE) pretreatment against DOX-induced nephrotoxicity. Randomly, twenty male Wistar rats were assigned into four groups: Control (no-treatment), DOX group (15mg/kg, i.p, once), DOX + CECE (100mg/kg) and DOX + CECE (200mg/kg)...
July 2023: Pakistan Journal of Pharmaceutical Sciences
#23
JOURNAL ARTICLE
Dipti Baskar, Preethish Veeramani-Kumar, Kiran Polavarapu, Saraswati Nashi, Seena Vengalil, Deepak Menon, Aneesha Thomas, Sai Bhargava Sanka, Keerthipriya Muddasu Suhasini, Akshata Huddar, Gopikrishnan Unnikrishnan, Mainak Bardhan, Priya Treesa Thomas, Nisha Manjunath, Nalini Atchayaram
BACKGROUND: Kennedy disease (KD) is a slowly progressive lower motor neuron degenerative disease. The prevalence of KD is unknown in India. AIM: To describe the phenotypic and laboratory features of an Indian cohort of KD patients. METHODS: A retrospective study was done on seven genetically confirmed KD patients based on demographic, clinical and laboratory details. RESULTS: Mean age at onset and presentation was 37 ± 11...
August 14, 2023: Internal Medicine Journal
#24
JOURNAL ARTICLE
Sridhar Shashi, Saraswati Nashi, Gautham Arunachal, N Venkatachalam, Hansashree Padmanabha, Pooja Mailankody, Deepak Menon, Faheem Arshad, Suvarna Alladi, Pavagada Mathuranath, Rohan R Mahale
No abstract text is available yet for this article.
2023: Annals of Indian Academy of Neurology
#25
JOURNAL ARTICLE
Lindsay A Wilson, William L Macken, Luke D Perry, Christopher J Record, Katherine R Schon, Rodrigo S S Frezatti, Sharika Raga, Kireshnee Naidu, Özlem Yayıcı Köken, Ipek Polat, Musambo M Kapapa, Natalia Dominik, Stephanie Efthymiou, Heba Morsy, Melissa Nel, Mahmoud R Fassad, Fei Gao, Krutik Patel, Maryke Schoonen, Michelle Bisschoff, Armand Vorster, Hallgeir Jonvik, Ronel Human, Elsa Lubbe, Malebo Nonyane, Seena Vengalil, Saraswati Nashi, Kosha Srivastava, Richard J L F Lemmers, Alisha Reyaz, Rinkle Mishra, Ana Töpf, Christina I Trainor, Elizabeth C Steyn, Amokelani C Mahungu, Patrick J van der Vliet, Ahmet Cevdet Ceylan, A Semra Hiz, Büşranur Çavdarlı, C Nur Semerci Gündüz, Gülay Güleç Ceylan, Madhu Nagappa, Karthik B Tallapaka, Periyasamy Govindaraj, Silvère M van der Maarel, Gayathri Narayanappa, Bevinahalli N Nandeesh, Somwe Wa Somwe, David R Bearden, Michelle P Kvalsund, Gita M Ramdharry, Yavuz Oktay, Uluç Yiş, Haluk Topaloğlu, Anna Sarkozy, Enrico Bugiardini, Franclo Henning, Jo M Wilmshurst, Jeannine M Heckmann, Robert McFarland, Robert W Taylor, Izelle Smuts, Francois H van der Westhuizen, Claudia Ferreira da Rosa Sobreira, Pedro J Tomaselli, Wilson Marques, Rohit Bhatia, Ashwin Dalal, M V Padma Srivastava, Sireesha Yareeda, Atchayaram Nalini, Venugopalan Y Vishnu, Kumarasamy Thangaraj, Volker Straub, Rita Horvath, Patrick F Chinnery, Robert D S Pitceathly, Francesco Muntoni, Henry Houlden, Jana Vandrovcova, Mary M Reilly, Michael G Hanna
Neuromuscular diseases (NMDs) affect ∼15 million people globally. In high income settings DNA-based diagnosis has transformed care pathways and led to gene-specific therapies. However, most affected families are in low-middle income countries (LMICs) with limited access to DNA-based diagnosis. Most (86%) published genetic data is derived from European ancestry. This marked genetic data inequality hampers understanding of genetic diversity and hinders accurate genetic diagnosis in all income settings...
July 30, 2023: Brain
#26
JOURNAL ARTICLE
Masanori Nashi, Hiromitsu Kishimoto, Masaki Kobayashi, Akira Tachibana, Motoo Suematsu, Shigeyoshi Fujiwara, Yoshiyuki Ota, Susumu Hashitani, Takeshi Shibatsuji, Tetsuya Nishida, Kazuma Fujimura, Shungo Furudoi, Yoshiki Ishida, Shoichiro Ishii, Tsuyoshi Fujita, Soichi Iwai, Takashi Shigeta, Takeshi Harada, Daisuke Miyai, Daisuke Takeda, Masaya Akashi, Kazuma Noguchi, Toshihiko Takenobu
BACKGROUND/PURPOSE: The incidence of medication-related osteonecrosis of the jaw is increasing worldwide, mostly due to the use of antiresorptive agents (ARAs) such as bisphosphonate (BP) and denosumab (Dmab). However, the proportion of BP-related osteonecrosis of the jaw (BRONJ) and Dmab-related osteonecrosis of the jaw (DRONJ) among all ARA-related osteonecrosis of the jaw (ARONJ) cases is not clear; this hinders appropriate treatment, recurrence-prevention planning, and avoidance of unnecessary Dmab withdrawal...
July 2023: Journal of Dental Sciences
#27
JOURNAL ARTICLE
Feng Xiao, Zhenli Long, Yun Guo, Hong Zhu, Zhe Zhang, Yao Xiao, Guowen Hu, Qing Yang, Kai Huang, Hua Guo
OBJECTIVE: Mago-nashi homolog (MAGOH) has been shown to play a pivotal part in various tumors. However, its specific contribution in lower-grade glioma (LGG) is still unknown. METHODS: Pan-cancer analysis was implemented to inspect the expression characteristics and prognostic significance of MAGOH in multiple tumors. The associations between MAGOH expression patterns and the pathological features of LGG were analyzed, as were the connections between MAGOH expression and the clinical traits, prognosis, biological activities, immune features, genomic variations, and responses to treatment in LGG...
June 30, 2023: Aging
#28
REVIEW
Mostafa Gouda, Hesham S Ghazzawy, Nashi Alqahtani, Xiaoli Li
One of the most significant developed technologies is the use of acoustic waves to determine the chemical structures of biological tissues and their bioactivities. In addition, the use of new acoustic techniques for in vivo visualizing and imaging of animal and plant cellular chemical compositions could significantly help pave the way toward advanced analytical technologies. For instance, acoustic wave sensors (AWSs) based on quartz crystal microbalance (QCM) were used to identify the aromas of fermenting tea such as linalool, geraniol, and trans-2-hexenal...
June 19, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#29
JOURNAL ARTICLE
Nashi K Alqahtani, Tareq M Alnemr, Fahad Al-Asmari, Salim A Ali
The use of natural ingredients to preserve the quality of fresh fruits is a promising approach to healthier products and a more sustainable industry. The present study was carried out to assess the effect of lactic acid (LA) and guava leaf extract (GLE) as natural preservatives on the quality parameters of Khalal Barhi dates. Physicochemical properties, antioxidant activity, color parameters, firmness, sensory properties, and yeast and mold counts of date fruits were evaluated during five weeks of storage at 4 ± 1 °C...
May 24, 2023: Foods (Basel, Switzerland)
#30
JOURNAL ARTICLE
Ristiawan Muji Laksono, Handono Kalim, Mohammad Saifur Rohman, Nashi Widodo, Muhammad Ramli Ahmad, Willy Halim
BACKGROUND: The molecular mechanism of pulsed radiofrequency (PRF) in chronic pain management is not fully understood. Chronic pain involves the activation of specific N-Methyl D-Aspartate receptors (NMDAR) to induce central sensitization. This study aims to determine the effect of PRF on central sensitization biomarker phosphorylated extracellular signal-regulated kinase (pERK), Ca2+ influx, cytosolic ATP level, and mitochondrial membrane potential (Δψm) of the sensitized dorsal root ganglion (DRG) neuron following NMDAR activation...
2023: Journal of Pain Research
#31
JOURNAL ARTICLE
Sumanth Shivaram, Manisha Gupta, A V R Taallapalli, Saraswati Nashi, Anita Mahadevan, P R Srijithesh
No abstract text is available yet for this article.
2023: Annals of Indian Academy of Neurology
#32
JOURNAL ARTICLE
Bayan J Almaghlouth, Nashi K Alqahtani, Khadijah I Alnabbat, Hisham A Mohamed, Tareq M Alnemr, Hosam M Habib
Byproducts of second-grade dates and sweet potato tubers of noncommercial standard are produced along with the main product and are just as important as the main product but cannot be sold in the open market, as they may not be considered acceptable by consumers. Such byproducts can be valorized through the manufacture of a wide range of functional food products with high market appeal, such as jams. The research approach of this study included measuring antioxidant activity, total flavonoids, polyphenols, physicochemical and color indices, pH, and total sugar, as well as conducting a sensory evaluation, of mixed jams composed of different ratios of date jam (DFJ) to sweet potato jam (SPJ), namely, DP1 (80:20), DP2 (70:30), DP3 (60:40), and DP4 (50:50)...
May 6, 2023: Foods (Basel, Switzerland)
#33
JOURNAL ARTICLE
Dipti Baskar, Seena Vengalil, Saraswati Nashi, Mainak Bardhan, Kosha Srivatsava, Sai Bhargava Sanka, Kiran Polavarapu, Deepak Menon, Veeramani Preethish-Kumar, Hansashree Padmanabha, Gautham Arunachal, Atchayaram Nalini
Chronic progressive external ophthalmoplegia (CPEO) is symptom complex with progressive ptosis and restricted ocular motility without diplopia. MYH2 myopathy is rare disorder presenting with CPEO and muscle weakness. We report two Indian patients of MYH2 myopathy with unique features. Patient-1 presented with early adult-onset esophageal reflux followed, proximal lower limb weakness, proptosis, CPEO without ptosis. He had elevated creatine kinase along with characteristic muscle MRI findings of prominent semitendinosus and medial gastrocnemius involvement...
May 2, 2023: Journal of Neuromuscular Diseases
#34
JOURNAL ARTICLE
Gopikrishnan Unnikrishnan, Kiran Polavarapu, Mainak Bardhan, Saraswati Nashi, Seena Vengalil, Veeramani Preethish-Kumar, Ravi Kiran Valasani, Akshata Huddar, Vikas Nishadham, Bevinahalli Nanjegowda Nandeesh, Atchayaram Nalini
BACKGROUND: The phenotypic spectrum of Fukutin-related protein (FKRP) mutations is highly variable and comprises of limb girdle muscular dystrophy (LGMD) R9 (previously LGMD 2I) and FKRP related congenital muscular dystrophies. OBJECTIVE: To identify the distinct genotype phenotype pattern in Indian patients with FKRP gene mutations. METHODS: We retrospectively reviewed the case files of patients with muscular dystrophy having a genetically confirmed FKRP mutation...
May 2, 2023: Journal of Neuromuscular Diseases
#35
JOURNAL ARTICLE
Ali A Youssef, Mustafa A Alrefae, Hesham H Khalil, Hisham I Abdullah, Zizi S Khalifa, Amani A Al Shaban, Hammam A Wali, Mazen R AlRajab, Omar M Saleh, Baher N Nashy
BACKGROUND: Direct oral anticoagulants are frequently used to treat post-myocardial infarction (MI) left ventricular thrombus (LVT). This study was conducted to evaluate the efficacy and safety of use of apixaban, compared to the standard warfarin therapy, in post-MI LVT. METHODS: This open-label, randomized controlled trial included patients with post-acute or recent anterior wall MI with transthoracic echocardiography-confirmed LVT. Patients were randomized to receive either apixaban 5 mg twice daily or warfarin to achieve an international normalized ratio of 2-3, in addition to dual antiplatelet therapy...
March 2023: CJC open
#36
JOURNAL ARTICLE
Nashi K Alqahtani, Hisham A Mohamed, Mahmoud E Moawad, Nancy S Younis, Maged E Mohamed
Date palm fruit ( Phoenix dactylifera : Arecaceae) is rich in essential nutrients and possesses several pharmacological and medicinal activities. The current study aimed to optimize a water bath-assisted extraction method for two cultivars of date palm fruits, Anbara (An) and Reziz (Rz), and investigated the protective effect of the optimized date palm fruit extract against CCl4 -induced liver toxicity in relation to oxidative stress, inflammation, apoptosis, and DNA integrity. The optimization process of two date palm fruit cultivars was applied, using response surface methodology through adjusting three "factors"; time, temperature, and rotation, to allow maximum contents of total phenolic (TPC), total flavonoid (TFC), reducing power (FRAP) and scavenging activity (ABTS) of the extract "responses"...
March 13, 2023: Foods (Basel, Switzerland)
#37
JOURNAL ARTICLE
Nashi K Alqahtani, Tareq M Alnemr, Abdullah K Alsalem, Mutlaq M Alotaibi, Maged Mohammed
The extraction of date syrup produces a large quantity of by-product known as date press cake (DPC). This study aimed to utilize valuable ingredients of the DPC by adding 0 (Control), 2, 4, and 6% (g/100 g) of its powder to drinkable yogurt before fermentation. The physicochemical properties, texture profile, and sensory evaluation of the treated DPC-based drinkable yogurt (DPC drinkable yogurt) were measured after fermentation and 5, 10, and 15 days of storage at 4 °C. The modeling of the most critical quality attributes, i...
March 13, 2023: Foods (Basel, Switzerland)
#38
JOURNAL ARTICLE
Nashi K Alqahtani, Tareq M Alnemr, Salim A Ali
The use of natural preservatives in the storage of fresh fruits is a promising approach to healthier and more sustainable food processing. The current study was conducted to evaluate the effect of pomegranate peel extract (PPE) and lactic acid (LA) as natural preservatives on the shelf life of Khalal Barhi date fruits. Physicochemical properties, antioxidant activity, color parameters, texture profile, sensory characteristics, and microbiological quality of date fruits were evaluated during six weeks of cold storage (4 ± 1 °C)...
March 9, 2023: Foods (Basel, Switzerland)
#39
JOURNAL ARTICLE
K G Koshy, S S Nashi, G B Kulkarni, A Vr Taalapalli
No abstract text is available yet for this article.
March 10, 2023: Journal of Postgraduate Medicine
#40
JOURNAL ARTICLE
Hesham S Ghazzawy, Nashi Alqahtani, Muhammad Munir, Naser S Alghanim, Maged Mohammed
Orchard cultural practices, i.e., irrigation, fertilizer, and fruit thinning, are crucially encompassed to enhance fruit yield and quality. Appropriate irrigation and fertilizer inputs improve plant growth and fruit quality, but their overuse leads to the degradation of the ecosystem and water quality, and other biological concerns. Potassium fertilizer improves fruit sugar and flavor and accelerates fruit ripening. Bunch thinning also significantly reduces the crop burden and improves the physicochemical characteristics of the fruit...
February 22, 2023: Plants (Basel, Switzerland)
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