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https://www.readbyqxmd.com/read/27754029/yia-03-05-blood-pressure-reduction-and-different-c-ebp%C3%AE-dna-binding-pattern-in-telmisartan-treated-angiotensinogen-g-217a-polymorphism-hypertensive-patients
#1
Risa Ramadhiani, Muhammad Saifur Rohman, Nashi Widodo, Valerinna Y S Putri, Mifetika Lukitasari, Jayarani F Putri, Didik H Utomo
OBJECTIVE: To investigate whether the angiotensinogen (AGT) G-217A polymorphism affects blood pressure response of telmisartan and valsartan in hypertensive patients. DESIGN AND METHOD: A total of 46 primary hypertensive patients, 23 patients received telmisartan 80 mg and 23 patients received valsartan 160 mg, were observed and followed up for 4 months. The AGT G-217A polymorphism was determined by PCR-RFLP and direct sequencing method. Blood pressure response was measured daytime (6 am - 10 pm), night-time (10 pm - 6 am), and 24 hours using twenty-four hours ambulatory blood pressure monitoring (ABPM)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642947/yia-03-05-blood-pressure-reduction-and-different-c-ebp%C3%AE-dna-binding-pattern-in-telmisartan-treated-angiotensinogen-g-217a-polymorphism-hypertensive-patients
#2
Risa Ramadhiani, Muhammad Saifur Rohman, Nashi Widodo, Valerinna Y S Putri, Mifetika Lukitasari, Jayarani F Putri, Didik H Utomo
OBJECTIVE: To investigate whether the angiotensinogen (AGT) G-217A polymorphism affects blood pressure response of telmisartan and valsartan in hypertensive patients. DESIGN AND METHOD: A total of 46 primary hypertensive patients, 23 patients received telmisartan 80 mg and 23 patients received valsartan 160 mg, were observed and followed up for 4 months. The AGT G-217A polymorphism was determined by PCR-RFLP and direct sequencing method. Blood pressure response was measured daytime (6 am - 10 pm), night-time (10 pm - 6 am), and 24 hours using twenty-four hours ambulatory blood pressure monitoring (ABPM)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27178530/large-scale-impact-of-climate-change-versus-land-use-change-on-future-biome-shifts-in-latin-america
#3
Alice Boit, Boris Sakschewski, Lena Boysen, Ana Cano-Crespo, Jan Clement, Nashieli Garcia Alaniz, Kasper Kok, Melanie Kolb, Fanny Langerwisch, Anja Rammig, René Sachse, Michiel van Eupen, Werner von Bloh, Delphine Zemp, Kirsten Thonicke
Climate change and land-use change are two major drivers of biome shifts causing habitat and biodiversity loss. What is missing is a continental-scale future projection of the estimated relative impacts of both drivers on biome shifts over the course of this century. Here, we provide such a projection for the biodiverse region of Latin America under four socio-economic development scenarios. We find that across all scenarios 5% to 6% of the total area will undergo biome shifts that can be attributed to climate change until 2099...
May 14, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27071313/two-highly-similar-dead-box-proteins-osrh2-and-osrh34-homologous-to-eukaryotic-initiation-factor-4aiii-play-roles-of-the-exon-junction-complex-in-regulating-growth-and-development-in-rice
#4
Chun-Kai Huang, Yi-Syuan Sie, Yu-Fu Chen, Tian-Sheng Huang, Chung-An Lu
BACKGROUND: The exon junction complex (EJC), which contains four core components, eukaryotic initiation factor 4AIII (eIF4AIII), MAGO/NASHI (MAGO), Y14/Tsunagi/RNA-binding protein 8A, and Barentsz/Metastatic lymph node 51, is formed in both nucleus and cytoplasm, and plays important roles in gene expression. Genes encoding core EJC components have been found in plants, including rice. Currently, the functional characterizations of MAGO and Y14 homologs have been demonstrated in rice. However, it is still unknown whether eIF4AIII is essential for the functional EJC in rice...
2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27056733/stress-chaperone-mortalin-regulates-human-melanogenesis
#5
Renu Wadhwa, Didik Priyandoko, Ran Gao, Nashi Widodo, Nupur Nigam, Ling Li, Hyo Min Ahn, Chae-Ok Yun, Nobuhiro Ando, Christian Mahe, Sunil C Kaul
In order to identify the cellular factors involved in human melanogenesis, we carried out shRNA-mediated loss-of-function screening in conjunction with induction of melanogenesis by 1-oleoyl-2-acetyl-glycerol (OAG) in human melanoma cells using biochemical and visual assays. Gene targets of the shRNAs (that caused loss of OAG-induced melanogenesis) and their pathways, as determined by bioinformatics, revealed involvement of proteins that regulate cell stress response, mitochondrial functions, proliferation, and apoptosis...
July 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27007901/identification-and-characterization-of-mago-and-y14-genes-in-hevea-brasiliensis
#6
Zi-Ping Yang, Hui-Liang Li, Dong Guo, Shi-Qing Peng
Mago nashi (MAGO) and Y14 proteins are highly conserved among eukaryotes. In this study, we identified two MAGO (designated as HbMAGO1 andHbMAGO2) and two Y14 (designated as HbY14aand HbY14b) genes in the rubber tree (Hevea brasiliensis) genome annotation. Multiple amino acid sequence alignments predicted that HbMAGO and HbY14 proteins are structurally similar to homologous proteins from other species. Tissue-specific expression profiles showed that HbMAGO and HbY14 genes were expressed in at least one of the tissues (bark, flower, latex, leaf and root) examined...
March 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/26960973/stress-chaperone-mortalin-contributes-to-epithelial-mesenchymal-transition-and-cancer-metastasis
#7
Youjin Na, Sunil C Kaul, Jihoon Ryu, Jung-Sun Lee, Hyo Min Ahn, Zeenia Kaul, Rajkumar S Kalra, Ling Li, Nashi Widodo, Chae-Ok Yun, Renu Wadhwa
Mortalin/mthsp70 (HSPA9) is a stress chaperone enriched in many cancers that has been implicated in carcinogenesis by promoting cell proliferation and survival. In the present study, we examined the clinical relevance of mortalin upregulation in carcinogenesis. Consistent with high mortalin expression in various human tumors and cell lines, we found that mortalin overexpression increased the migration and invasiveness of breast cancer cells. Expression analyses revealed that proteins involved in focal adhesion, PI3K-Akt and JAK-STAT signaling, all known to play key roles in cell migration and epithelial-to-mesenchymal transition (EMT), were upregulated in mortalin-expressing cancer cells...
March 9, 2016: Cancer Research
https://www.readbyqxmd.com/read/26948107/the-long-and-short-of-cephalomedullary-nails-in-the-treatment-of-osteoporotic-pertrochanteric-fracture
#8
Choon Chiet Hong, Nazrul Nashi, Milindu Chanaka Makandura, Jiong Hao Jonathan Tan, Luke Peter, Diarmuid Murphy
INTRODUCTION: Pertrochanteric fractures after low energy trauma are common among osteoporotic patients. Although the use of intramedullary devices to treat such fractures is becoming increasingly popular, there is a paucity of data comparing the outcomes of the use of short cephalomedullary nails (SCN) and the use of long cephalomedullary nails (LCN). This study aimed to compare the outcomes of patients with osteoporotic pertrochanteric fractures who were treated using LCN with the outcomes of those who were treated using SCN...
March 7, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26892829/cemented-hemiarthroplasty-in-traumatic-displaced-femoral-neck-fractures-and-deep-vein-thrombosis-is-there-really-a-link
#9
Choon Chiet Hong, Nazrul Nashi, Milindu Chanaka Makandura, Lingaraj Krishna
INTRODUCTION: Traumatic displaced femoral neck fractures in the elderly can be treated with cemented or uncemented hemiarthroplasty with good outcomes. Earlier studies reported a higher incidence of deep vein thrombosis (DVT) associated with cemented prostheses in elective total hip or knee arthroplasty. In addition, the hypercoagulable state after a traumatic femoral neck fracture and possible thrombogenic properties of bone cement could put these patients at greater risk for thromboembolism...
February 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26870110/gender-differences-among-discrimination-stigma-experienced-by-depressive-patients-in-pakistan
#10
Nashi Khan, Rukhsana Kausar, Adeela Khalid, Anum Farooq
OBJECTIVE: This study aims to examine Gender Difference in the level of Discrimination and Stigma experienced by people diagnosed with Major Depressive Disorder in Pakistan. It was hypothesized that Women diagnosed with Depression are likely to be experiencing more Discrimination and Internalized Stigma in comparison to Men. METHODS: This is a Cross Sectional Study. Thirty eight patients diagnosed with Major Depressive Disorder recruited from different Government Sector Hospitals of Lahore; were approached after obtaining informed consent...
November 2015: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26852291/cardiac-structure-and-function-and-ventricular-arterial-interaction-11%C3%A2-years-following-a-pregnancy-with-preeclampsia
#11
Maha Al-Nashi, Maria J Eriksson, Eva Östlund, Katarina Bremme, Thomas Kahan
Preeclampsia (PE) is associated with acute left ventricular dysfunction. Whether these changes eventually resolve remains unclear. This study assessed left and right ventricular structure and function, and ventricular-arterial interaction in 15 women 11 years after a pregnancy with PE and 16 matched control subjects with a normal pregnancy. We found normal left and right ventricular dimensions, systolic function, and global left ventricular strain, with no differences between the groups. In addition, indices of diastolic function, left and right atrial size, and amino-terminal pro-brain natriuretic peptide were normal and did not differ between the groups...
April 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/26623571/studies-of-bolivian-ptiliidae-coleoptera-2-the-subfamily-acrotrichinae-including-two-new-genera-petrotrichis-and-microtrichis-and-eight-new-species-of-acrotrichis
#12
Michael Darby
This is the second report on a collection of Ptiliidae from Bolivian forest leaf litter made by Dr Petr Baňař of the Brno Museum (Czech Republic) in 2013. A small collection of Bolivian Acrotrichis in the Natural Museum, London, made by H. Mendel and M.V.L. Barclay in 2004 is also included. Two new monotypic genera are described Petrotrichis gen. n. (Acrotrichini), type species P. rotundata sp. n., and Microtrichis gen. n. (Nephanini), type species M. pectana sp. n., together with eight new species of Acrotrichis: A...
2015: Zootaxa
https://www.readbyqxmd.com/read/26495141/genetic-variants-of-c-5312t-ren-increased-renin-levels-and-diastolic-blood-pressure-response-to-angiotensin-receptor-blockers
#13
Mohammad Saifur Rohman, Ika Arum Dewi Satiti, Nashi Widodo, Mifetika Lukitasari, Hidayat Sujuti
Renin catalyzes the cleavage of angiotensinogen into angiotensin I. Genetic variant C-5312T of renin enhancer has been reported to increase in vitro renin gene transcription. However, no obvious in vivo study was performed to see the renin level in C-5312T when treated with angiotensin receptor blockers (ARB). Therefore, this study aimed to investigate the serum renin level and blood pressure response in ARB treated hypertensive patients. Single nucleotide polymorphism (SNP) of C-5312T was identified in 55 hypertensive patients by using multiplex PCR and renin serum level was assayed by ELISA...
2015: International Journal of Hypertension
https://www.readbyqxmd.com/read/26493135/mago-nashi-is-involved-in-meristem-organization-pollen-formation-and-seed-development-in-arabidopsis
#14
Nam-Il Park, Edward C Yeung, Douglas G Muench
Mago Nashi (Mago) is involved in several processes related to mRNA physiology in animal cells, including mRNA export from the nucleus, cytoplasmic mRNA localization, non-sense mediated mRNA decay, and translation. These cellular roles are visible as defects in development when Mago gene expression is modified in mutant model animal systems. Mago gene orthologs exist in plants, however, their functional roles in growth and development have not been well studied. Using an RNA interference (RNAi) approach, we produced transgenic Arabidopsis plants that had reduced levels of AtMago mRNA...
April 2009: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/26316933/treatment-of-non-small-cell-lung-cancer-with-erlotinib-following-gefitinib-induced-hepatotoxicity-review-of-8-clinical-cases
#15
Yukihiro Yano, Yoshinobu Namba, Masahide Mori, Yukie Nakazawa, Ayumi Nashi, Shinichi Kagami, Manabu Niinaka, Tsutomu Yoneda, Hiromi Kimura, Toshihiko Yamaguchi, Soichiro Yokota
Objective. Gefitinib often induces liver damage. A few reports have described that the subsequent administration of erlotinib was associated with less hepatotoxicity, but the safety and efficacy of this treatment are still not fully investigated. Therefore, we evaluated retrospectively the patients with erlotinib following gefitinib-induced hepatotoxicity. Methods and Patients. We retrospectively reviewed the medical records between December 2007 and March 2010. The patients were evaluated including the following information: age, gender, histology of lung cancer, performance status, smoking status, epidermal growth factor receptor (EGFR) mutation status, liver metastasis, viral hepatitis, alcoholic liver injury, clinical response, and hepatotoxicity due to EGFR tyrosine kinase inhibitors...
2012: Lung Cancer International
https://www.readbyqxmd.com/read/26254464/double-edge-closure-a-novel-technique-for-reducing-post-thoracotomy-pain-a-randomized-control-study
#16
Mohammed Ahmed El-Hag-Aly, Medhat Reda Nashy
OBJECTIVES: Thoracic surgeons being doctors, spend much effort not only to manage pathologies but also to make their procedures painless. Many surgical manoeuvres have been evolved to reduce post-thoracotomy pain with its associated morbidities. This trial aimed to study the impact of double edge closure technique on post-thoracotomy pain. METHODS: This was a prospective pre-muted block randomized study of 120 patients who had posterolateral thoracotomy. They were equally divided into two groups, the first in which double edge closure technique was used (DE group), and the other group in which the usual pericostal sutures were used (PC group)...
November 2015: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26090220/genetic-variant-of-c-5434t-ren-enhancer-on-serum-renin-levels-and-binding-pattern-of-signal-transducers-and-activators-transcription-3
#17
Imama Maslahah, Mohammad Saifur Rohman, Nashi Widodo, Agustina Tri Endharti, Didik Utomo
The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. However, the mechanism associated with the transcription level changes remains unknown, and only a few reports exist that discussed serum renin levels on C-5434T of REN. Thus, this study aims to investigate the relationship between genetic variant C-5434T of REN enhancer and serum renin levels in Indonesian hypertensive patients...
2015: International Journal of Hypertension
https://www.readbyqxmd.com/read/26005274/selective-inhibition-on-rage-binding-ages-required-by-bioactive-peptide-alpha-s2-case-in-protein-from-goat-ethawah-breed-milk-study-of-biological-modeling
#18
Fatchiyah Fatchiyah, Ferlany Hardiyanti, Nashi Widodo
BACKGROUND: Advanced Glycation End Products (AGE) play a pivotal role in the development various degenerative diseases such as diabetes, cardiovascular disease, stroke, neuropathy, and nephropathy. Different studies have been done to employ AGEs as drug targets for the diseases therapy. In previous study, we have found bioactive peptide from Ethawah goat milk for anti-diabetic that may work through inhibition of AGE receptor function. However, the mechanism of bioactive peptides inhibits AGE- AGE receptor (RAGE) bonding still not clear yet...
April 2015: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/25998524/a-molecular-physiological-review-of-vegetative-desiccation-tolerance-in-the-resurrection-plant-xerophyta-viscosa-baker
#19
REVIEW
Jill M Farrant, Keren Cooper, Amelia Hilgart, Kamal O Abdalla, Joanne Bentley, Jennifer A Thomson, Halford J W Dace, Nashied Peton, Sagadevan G Mundree, Mohamed S Rafudeen
Provides a first comprehensive review of integrated physiological and molecular aspects of desiccation tolerance Xerophyta viscosa. A synopsis of biotechnological studies being undertaken to improve drought tolerance in maize is given. Xerophyta viscosa (Baker) is a monocotyledonous resurrection plant from the family Vellociacea that occurs in summer-rainfall areas of South Africa, Lesotho and Swaziland. It inhabits rocky terrain in exposed grasslands and frequently experiences periods of water deficit. Being a resurrection plant it tolerates the loss of 95% of total cellular water, regaining full metabolic competency within 3 days of rehydration...
August 2015: Planta
https://www.readbyqxmd.com/read/25845361/evaluation-of-yeasts-from-tibetan-fermented-products-as-agents-for-biocontrol-of-blue-mold-of-nashi-pear-fruits
#20
Hao Hu, Yang Xu, Huang-ping Lu, Rui Xiao, Xiao-dong Zheng, Ting Yu
A total of 20 strains of yeast isolated from Tibetan fermented products were screened for antagonism against blue mold of pear caused by Penicillium expansum. Six isolates that inhibited incidence of postharvest decay by 35% or more were selected for further screening. Among them, the most effective was Rhodotorula mucilaginosa. The results showed that washed cell suspensions of R. mucilaginosa yielded better antagonistic efficacy than unwashed cell-culture mixtures, cell-free culture filtrates, and autoclaved cell cultures...
April 2015: Journal of Zhejiang University. Science. B
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