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https://www.readbyqxmd.com/read/28566540/the-exon-junction-complex-senses-energetic-stress-and-regulates-contractility-and-cell-architecture-in-cardiac-myocytes
#1
Olivier A Pierrat, Anju Paudyal, James Woodruff, Olga Koroleva, Samuel Boateng
The Exon Junction Complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesised that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocytes, we examined the cellular distribution of two EJC components eIF4A3 and mago nashi homologue (Mago) in response to metabolic stress. There was significant relocalisation of eIF4A3 and Mago from the nucleus to cytoplasm following 18 hours of hypoxia...
May 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28402567/nonsense-mediated-mrna-decay-in-tetrahymena-is-ejc-independent-and-requires-a-protozoa-specific-nuclease
#2
Miao Tian, Wentao Yang, Jing Zhang, Huai Dang, Xingyi Lu, Chengjie Fu, Wei Miao
Nonsense-mediated mRNA decay (NMD) is essential for removing premature termination codon-containing transcripts from cells. Studying the NMD pathway in model organisms can help to elucidate the NMD mechanism in humans and improve our understanding of how this biologically important process has evolved. Ciliates are among the earliest branching eukaryotes; their NMD mechanism is poorly understood and may be primordial. We demonstrate that highly conserved Upf proteins (Upf1a, Upf2 and Upf3) are involved in the NMD pathway of the ciliate, Tetrahymena thermophila...
April 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28399169/a-photoperiod-responsive-protein-compendium-and-conceptual-proteome-roadmap-outline-in-maize-grown-in-growth-chambers-with-controlled-conditions
#3
You-Zhi Li, Xian-Wei Fan, Qiang Chen, Hao Zhong
Maize (Zea mays L.) is one of the major staple food crops of the world. However, high photoperiod sensitivity, especially for tropical germplasms, impedes attempts to improve maize agronomical traits by integration of tropical and temperate maize germplasms. Physiological and phenotypic responses of maize to photoperiod have widely been investigated based on multi-site field observations; however, proteome-based responsive mechanisms under controlled photoperiod regimes, nutrient and moisture soils are not yet well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28079318/duchenne-muscular-dystrophy-and-becker-muscular-dystrophy-confirmed-by-multiplex-ligation-dependent-probe-amplification-genotype-phenotype-correlation-in-a-large-cohort
#4
Seena Vengalil, Veeramani Preethish-Kumar, Kiran Polavarapu, Manjunath Mahadevappa, Deepha Sekar, Meera Purushottam, Priya Treesa Thomas, Saraswathi Nashi, Atchayaram Nalini
BACKGROUND AND PURPOSE: Studies of cases of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) confirmed by multiplex ligation-dependent probe amplification (MLPA) have determined the clinical characteristics, genotype, and relations between the reading frame and phenotype for different countries. This is the first such study from India. METHODS: A retrospective genotype-phenotype analysis of 317 MLPA-confirmed patients with DMD or BMD who visited the neuromuscular clinic of a quaternary referral center in southern India...
January 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28012415/comparing-sleep-profiles-between-patients-with-juvenile-myoclonic-epilepsy-and-symptomatic-partial-epilepsy-sleep-questionnaire-based-study
#5
Nashi Saraswati, Chetan Nayak, Sanjib Sinha, Madhu Nagappa, Kandavel Thennarasu, Arun B Taly
OBJECTIVES: Patients with epilepsy commonly report excessive daytime sleepiness and daytime fatigue, which may be attributed to the direct effect of seizures, a side effect of antiepileptic drugs or a combination of the two. The aim of the study was to compare sleep profiles in patients with juvenile myoclonic epilepsy (JME) and symptomatic partial epilepsy (PE) in drug naïve and treated patients using standardized sleep questionnaires. METHODS: Three study groups: - 1) juvenile myoclonic epilepsy (N=40) [drug naïve (N=20); On sodium valproate (SVA) (N=20)]; 2) symptomatic partial epilepsy (N=40) [drug naïve (N=20); On carbamazepine (CBZ) (N=20)]; 3) healthy controls (N=40) completed 3 standardized sleep questionnaires - Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and NIMHANS Comprehensive Sleep Disorders Questionnaire...
December 21, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27942375/coping-with-potential-bi-parental-inbreeding-limited-pollen-and-seed-dispersal-and-large-genets-in-the-dioecious-marine-angiosperm-thalassia-testudinum
#6
Brigitta Ine Van Tussenbroek, Tania Valdivia-Carrillo, Irene Teresa Rodríguez-Virgen, Sylvia Nashieli Marisela Sanabria-Alcaraz, Karina Jiménez-Durán, Kor Jent Van Dijk, Guadalupe Judith Marquez-Guzmán
The high prevalence of dioecy in marine angiosperms or seagrasses (>50% of all species) is thought to enforce cross-fertilization. However, seagrasses are clonal plants, and they may still be subject to sibling-mating or bi-parental inbreeding if the genetic neighborhood is smaller than the size of the genets. We tested this by determining the genetic neighborhoods of the dioecious seagrass Thalassia testudinum at two sites (Back-Reef and Mid-Lagoon) in Puerto Morelos Reef Lagoon, Mexico, by measuring dispersal of pollen and seeds in situ, and by fine-scale spatial autocorrelation analysis with eight polymorphic microsatellite DNA markers...
August 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27754029/yia-03-05-blood-pressure-reduction-and-different-c-ebp%C3%AE-dna-binding-pattern-in-telmisartan-treated-angiotensinogen-g-217a-polymorphism-hypertensive-patients
#7
Risa Ramadhiani, Muhammad Saifur Rohman, Nashi Widodo, Valerinna Y S Putri, Mifetika Lukitasari, Jayarani F Putri, Didik H Utomo
OBJECTIVE: To investigate whether the angiotensinogen (AGT) G-217A polymorphism affects blood pressure response of telmisartan and valsartan in hypertensive patients. DESIGN AND METHOD: A total of 46 primary hypertensive patients, 23 patients received telmisartan 80 mg and 23 patients received valsartan 160 mg, were observed and followed up for 4 months. The AGT G-217A polymorphism was determined by PCR-RFLP and direct sequencing method. Blood pressure response was measured daytime (6 am - 10 pm), night-time (10 pm - 6 am), and 24 hours using twenty-four hours ambulatory blood pressure monitoring (ABPM)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642947/yia-03-05-blood-pressure-reduction-and-different-c-ebp%C3%AE-dna-binding-pattern-in-telmisartan-treated-angiotensinogen-g-217a-polymorphism-hypertensive-patients
#8
Risa Ramadhiani, Muhammad Saifur Rohman, Nashi Widodo, Valerinna Y S Putri, Mifetika Lukitasari, Jayarani F Putri, Didik H Utomo
OBJECTIVE: To investigate whether the angiotensinogen (AGT) G-217A polymorphism affects blood pressure response of telmisartan and valsartan in hypertensive patients. DESIGN AND METHOD: A total of 46 primary hypertensive patients, 23 patients received telmisartan 80 mg and 23 patients received valsartan 160 mg, were observed and followed up for 4 months. The AGT G-217A polymorphism was determined by PCR-RFLP and direct sequencing method. Blood pressure response was measured daytime (6 am - 10 pm), night-time (10 pm - 6 am), and 24 hours using twenty-four hours ambulatory blood pressure monitoring (ABPM)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27178530/large-scale-impact-of-climate-change-versus-land-use-change-on-future-biome-shifts-in-latin-america
#9
Alice Boit, Boris Sakschewski, Lena Boysen, Ana Cano-Crespo, Jan Clement, Nashieli Garcia Alaniz, Kasper Kok, Melanie Kolb, Fanny Langerwisch, Anja Rammig, René Sachse, Michiel van Eupen, Werner von Bloh, Delphine Zemp, Kirsten Thonicke
Climate change and land-use change are two major drivers of biome shifts causing habitat and biodiversity loss. What is missing is a continental-scale future projection of the estimated relative impacts of both drivers on biome shifts over the course of this century. Here, we provide such a projection for the biodiverse region of Latin America under four socio-economic development scenarios. We find that across all scenarios 5% to 6% of the total area will undergo biome shifts that can be attributed to climate change until 2099...
May 14, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27071313/two-highly-similar-dead-box-proteins-osrh2-and-osrh34-homologous-to-eukaryotic-initiation-factor-4aiii-play-roles-of-the-exon-junction-complex-in-regulating-growth-and-development-in-rice
#10
Chun-Kai Huang, Yi-Syuan Sie, Yu-Fu Chen, Tian-Sheng Huang, Chung-An Lu
BACKGROUND: The exon junction complex (EJC), which contains four core components, eukaryotic initiation factor 4AIII (eIF4AIII), MAGO/NASHI (MAGO), Y14/Tsunagi/RNA-binding protein 8A, and Barentsz/Metastatic lymph node 51, is formed in both nucleus and cytoplasm, and plays important roles in gene expression. Genes encoding core EJC components have been found in plants, including rice. Currently, the functional characterizations of MAGO and Y14 homologs have been demonstrated in rice. However, it is still unknown whether eIF4AIII is essential for the functional EJC in rice...
April 12, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27056733/stress-chaperone-mortalin-regulates-human-melanogenesis
#11
Renu Wadhwa, Didik Priyandoko, Ran Gao, Nashi Widodo, Nupur Nigam, Ling Li, Hyo Min Ahn, Chae-Ok Yun, Nobuhiro Ando, Christian Mahe, Sunil C Kaul
In order to identify the cellular factors involved in human melanogenesis, we carried out shRNA-mediated loss-of-function screening in conjunction with induction of melanogenesis by 1-oleoyl-2-acetyl-glycerol (OAG) in human melanoma cells using biochemical and visual assays. Gene targets of the shRNAs (that caused loss of OAG-induced melanogenesis) and their pathways, as determined by bioinformatics, revealed involvement of proteins that regulate cell stress response, mitochondrial functions, proliferation, and apoptosis...
July 2016: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/27007901/identification-and-characterization-of-mago-and-y14-genes-in-hevea-brasiliensis
#12
Zi-Ping Yang, Hui-Liang Li, Dong Guo, Shi-Qing Peng
Mago nashi (MAGO) and Y14 proteins are highly conserved among eukaryotes. In this study, we identified two MAGO (designated as HbMAGO1 andHbMAGO2) and two Y14 (designated as HbY14aand HbY14b) genes in the rubber tree (Hevea brasiliensis) genome annotation. Multiple amino acid sequence alignments predicted that HbMAGO and HbY14 proteins are structurally similar to homologous proteins from other species. Tissue-specific expression profiles showed that HbMAGO and HbY14 genes were expressed in at least one of the tissues (bark, flower, latex, leaf and root) examined...
March 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/26960973/stress-chaperone-mortalin-contributes-to-epithelial-mesenchymal-transition-and-cancer-metastasis
#13
Youjin Na, Sunil C Kaul, Jihoon Ryu, Jung-Sun Lee, Hyo Min Ahn, Zeenia Kaul, Rajkumar S Kalra, Ling Li, Nashi Widodo, Chae-Ok Yun, Renu Wadhwa
Mortalin/mthsp70 (HSPA9) is a stress chaperone enriched in many cancers that has been implicated in carcinogenesis by promoting cell proliferation and survival. In the present study, we examined the clinical relevance of mortalin upregulation in carcinogenesis. Consistent with high mortalin expression in various human tumors and cell lines, we found that mortalin overexpression increased the migration and invasiveness of breast cancer cells. Expression analyses revealed that proteins involved in focal adhesion, PI3K-Akt and JAK-STAT signaling, all known to play key roles in cell migration and epithelial-to-mesenchymal transition (EMT), were upregulated in mortalin-expressing cancer cells...
March 9, 2016: Cancer Research
https://www.readbyqxmd.com/read/26948107/the-long-and-short-of-cephalomedullary-nails-in-the-treatment-of-osteoporotic-pertrochanteric-fracture
#14
Choon Chiet Hong, Nazrul Nashi, Milindu Chanaka Makandura, Jiong Hao Jonathan Tan, Luke Peter, Diarmuid Murphy
INTRODUCTION: Pertrochanteric fractures after low-energy trauma are common among osteoporotic patients. Although the use of intramedullary devices to treat such fractures is becoming increasingly popular, there is a paucity of data comparing the outcomes of the use of short cephalomedullary nails (SCN) with the use of long cephalomedullary nails (LCN). This study aimed to compare the outcomes of treatment using LCN with treatment using SCN for patients with osteoporotic pertrochanteric fractures...
February 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/26892829/cemented-hemiarthroplasty-in-traumatic-displaced-femoral-neck-fractures-and-deep-vein-thrombosis-is-there-really-a-link
#15
Choon Chiet Hong, Nazrul Nashi, Milindu Chanaka Makandura, Lingaraj Krishna
INTRODUCTION: Traumatic displaced femoral neck fractures in the elderly can be treated with cemented or uncemented hemiarthroplasty with good outcomes. Earlier studies reported a higher incidence of deep vein thrombosis (DVT) associated with cemented prostheses in elective total hip or knee arthroplasty. In addition, the hypercoagulable state after a traumatic femoral neck fracture and possible thrombogenic properties of bone cement could put these patients at greater risk for thromboembolism...
February 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/26870110/gender-differences-among-discrimination-stigma-experienced-by-depressive-patients-in-pakistan
#16
Nashi Khan, Rukhsana Kausar, Adeela Khalid, Anum Farooq
OBJECTIVE: This study aims to examine Gender Difference in the level of Discrimination and Stigma experienced by people diagnosed with Major Depressive Disorder in Pakistan. It was hypothesized that Women diagnosed with Depression are likely to be experiencing more Discrimination and Internalized Stigma in comparison to Men. METHODS: This is a Cross Sectional Study. Thirty eight patients diagnosed with Major Depressive Disorder recruited from different Government Sector Hospitals of Lahore; were approached after obtaining informed consent...
November 2015: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26852291/cardiac-structure-and-function-and-ventricular-arterial-interaction-11%C3%A2-years-following-a-pregnancy-with-preeclampsia
#17
Maha Al-Nashi, Maria J Eriksson, Eva Östlund, Katarina Bremme, Thomas Kahan
Preeclampsia (PE) is associated with acute left ventricular dysfunction. Whether these changes eventually resolve remains unclear. This study assessed left and right ventricular structure and function, and ventricular-arterial interaction in 15 women 11 years after a pregnancy with PE and 16 matched control subjects with a normal pregnancy. We found normal left and right ventricular dimensions, systolic function, and global left ventricular strain, with no differences between the groups. In addition, indices of diastolic function, left and right atrial size, and amino-terminal pro-brain natriuretic peptide were normal and did not differ between the groups...
April 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/26623571/studies-of-bolivian-ptiliidae-coleoptera-2-the-subfamily-acrotrichinae-including-two-new-genera-petrotrichis-and-microtrichis-and-eight-new-species-of-acrotrichis
#18
Michael Darby
This is the second report on a collection of Ptiliidae from Bolivian forest leaf litter made by Dr Petr Baňař of the Brno Museum (Czech Republic) in 2013. A small collection of Bolivian Acrotrichis in the Natural Museum, London, made by H. Mendel and M.V.L. Barclay in 2004 is also included. Two new monotypic genera are described Petrotrichis gen. n. (Acrotrichini), type species P. rotundata sp. n., and Microtrichis gen. n. (Nephanini), type species M. pectana sp. n., together with eight new species of Acrotrichis: A...
2015: Zootaxa
https://www.readbyqxmd.com/read/26495141/genetic-variants-of-c-5312t-ren-increased-renin-levels-and-diastolic-blood-pressure-response-to-angiotensin-receptor-blockers
#19
Mohammad Saifur Rohman, Ika Arum Dewi Satiti, Nashi Widodo, Mifetika Lukitasari, Hidayat Sujuti
Renin catalyzes the cleavage of angiotensinogen into angiotensin I. Genetic variant C-5312T of renin enhancer has been reported to increase in vitro renin gene transcription. However, no obvious in vivo study was performed to see the renin level in C-5312T when treated with angiotensin receptor blockers (ARB). Therefore, this study aimed to investigate the serum renin level and blood pressure response in ARB treated hypertensive patients. Single nucleotide polymorphism (SNP) of C-5312T was identified in 55 hypertensive patients by using multiplex PCR and renin serum level was assayed by ELISA...
2015: International Journal of Hypertension
https://www.readbyqxmd.com/read/26493135/mago-nashi-is-involved-in-meristem-organization-pollen-formation-and-seed-development-in-arabidopsis
#20
Nam-Il Park, Edward C Yeung, Douglas G Muench
Mago Nashi (Mago) is involved in several processes related to mRNA physiology in animal cells, including mRNA export from the nucleus, cytoplasmic mRNA localization, non-sense mediated mRNA decay, and translation. These cellular roles are visible as defects in development when Mago gene expression is modified in mutant model animal systems. Mago gene orthologs exist in plants, however, their functional roles in growth and development have not been well studied. Using an RNA interference (RNAi) approach, we produced transgenic Arabidopsis plants that had reduced levels of AtMago mRNA...
April 2009: Plant Science: An International Journal of Experimental Plant Biology
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