keyword
https://read.qxmd.com/read/38477820/loss-of-pa28%C3%AE-exacerbates-imbalanced-differentiation-of-bone-marrow-stromal-cells-during-bone-formation-and-bone-healing-in-mice-pa28%C3%AE-accelerate-bone-formation-and-bone-healing
#21
JOURNAL ARTICLE
Qian Chen, ZuPing Wu, Shi YuJie, ZaiYe Li, JiaKang Yang, MoYuan Qu, ShiYu Zhang, Zheng Wang, Ning Ji, Jing Li, YingQiang Shen, Liang Xie, Qianming Chen
Proteasome activator subunit 3 (PA28γ) is a member of the proteasome activator family, which mainly regulates the degradation and stability of proteins. Studies have shown that it plays crucial roles in lipid formation, stemness maintenance and blood vessel formation. However, few studies have clarified the association between PA28γ and bone diseases. Herein, we identified PA28γ as a previously unknown regulator of bone homeostasis that coordinates bone formation and lipid accumulation. PA28γ-knockout mice presented with the characteristics of low bone mass and accumulation of lipids...
January 31, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477792/lepr-stromal-cells-respond-to-periodontitis-and-attenuate-alveolar-bone-repair-via-ccrl2-mediated-wnt-inhibition
#22
JOURNAL ARTICLE
Yongliang Chen, Yuteng Weng, Jie Huang, Qin Li, Bin Sun, Haicheng Wang, Zuolin Wang
The impaired bone healing in tooth extraction sockets due to periodontitis presents a major obstacle to restoring oral health. The mechanisms regulating osteogenic capacity of jawbone derived stromal cells in periodontitis microenvironment remain elusive. Leptin receptor (LepR) expressing stromal cells, which largely overlap with Cxcl12-abundant reticular (CAR) cells in bone tissue, rapidly proliferate and differentiate into bone-forming cells during extraction socket healing to support alveolar bone repair...
March 12, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477772/femoral-neck-width-genetic-risk-score-is-a-novel-independent-risk-factor-for-hip-fractures
#23
JOURNAL ARTICLE
Jonathan H Tobias, Maria Nethander, Benjamin G Faber, Sophie V Heppenstall, Raja Ebsim, Tim Cootes, Claudia Lindner, Fiona R Saunders, Jenny S Gregory, Richard M Aspden, Nicholas C Harvey, John P Kemp, Monika Frysz, Claes Ohlsson
Femoral neck width (FNW) derived from dual energy X-ray absorptiometry (DXA) scans may provide a useful adjunct to hip fracture prediction, by providing depth information missing from bone mineral density (BMD) measurements. Therefore, we investigated whether FNW is related to hip fracture risk independently of FN-BMD, using a genetic approach. FNW was derived from points automatically placed on the proximal femur using hip DXA scans from 38,150 individuals (mean age 63.8 years, 48.0% males) in UK Biobank (UKB)...
January 12, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38476262/deciphering-the-impacts-of-modulating-the-wnt-planar-cell-polarity-pcp-pathway-on-alveolar-repair
#24
JOURNAL ARTICLE
Sally Yunsun Kim, David McTeague, Sek-Shir Cheong, Matthew Hind, Charlotte H Dean
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant Wnt signalling is associated with lung diseases including emphysema, idiopathic pulmonary fibrosis and pulmonary arterial hypertension but how Wnt signalling contributes to these diseases is still unclear. There are several alternative pathways that can be stimulated upon Wnt ligand binding, one of these is the Planar Cell Polarity (PCP) pathway which induces actin cytoskeleton remodelling...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38476024/carm1-drives-triple-negative-breast-cancer-progression-by-coordinating-with-hif1a
#25
JOURNAL ARTICLE
Dandan Feng, Jie Gao, Ruiqiong Liu, Wei Liu, Tianyang Gao, Yunkai Yang, Die Zhang, Tianshu Yang, Xin Yin, Hefen Yu, Wei Huang, Yan Wang
Coactivator-associated arginine methyltransferase 1 (CARM1) promotes the development and metastasis of estrogen receptor alpha (ERα)-positive breast cancer. The function of CARM1 in triple-negative breast cancer (TNBC) is still unclear and requires further exploration. Here, we report that CARM1 promotes proliferation, epithelial-mesenchymal transition (EMT), and stemness in TNBC. CARM1 is upregulated in multiple cancers and its expression correlates with breast cancer progression. Genome-wide analysis of CARM1 showed that CARM1 is recruited by hypoxia-inducible factor 1 subunit alpha (HIF1A) and occupy the promoters of CDK4, Cyclin D1, β-catenin, HIF1A, MALAT1, and SIX1 critically involved in cell cycle, HIF-1 signaling pathway, Wnt signaling pathway, VEGF signaling pathway, thereby modulating the proliferation and invasion of TNBC cells...
March 13, 2024: Protein & Cell
https://read.qxmd.com/read/38474826/epigenetic-effects-of-resveratrol-on-oncogenic-signaling-in-breast-cancer
#26
JOURNAL ARTICLE
Lucinda Kurzava Kendall, Yuexi Ma, Tony Yang, Katarzyna Lubecka, Barbara Stefanska
The crosstalk between oncogenic signaling pathways plays a crucial role in driving cancer development. We previously demonstrated that dietary polyphenols, specifically resveratrol (RSV) and other stilbenoids, epigenetically target oncogenes for silencing via DNA hypermethylation in breast cancer. In the present study, we identify signal transduction regulators among RSV-hypermethylated targets and investigate the functional role of RSV-mediated DNA hypermethylation in the regulation of Hedgehog and Wnt signaling...
February 29, 2024: Nutrients
https://read.qxmd.com/read/38474604/effects-and-mechanisms-of-luteolin-a-plant-based-flavonoid-in-the-prevention-of-cancers-via-modulation-of-inflammation-and-cell-signaling-molecules
#27
REVIEW
Saleh A Almatroodi, Ahmad Almatroudi, Hajed Obaid A Alharbi, Amjad Ali Khan, Arshad Husain Rahmani
Luteolin, a flavonoid, is mainly found in various vegetables and fruits, including carrots, cabbages, onions, parsley, apples, broccoli, and peppers. Extensive research in vivo and in vitro has been performed to explore its role in disease prevention and treatment. Moreover, this compound possesses the ability to combat cancer by modulating cell-signaling pathways across various types of cancer. The studies have confirmed that luteolin can inhibit cancer-cell survival and proliferation, angiogenesis, invasion, metastasis, mTOR/PI3K/Akt, STAT3, Wnt/β-catenin, and cell-cycle arrest, and induce apoptosis...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474338/persistent-%C3%AE-hexachlorocyclohexane-exposure-impacts-cellular-metabolism-with-a-specific-signature-in-normal-human-melanocytes
#28
JOURNAL ARTICLE
Federica Papaccio, Silvia Caputo, Alessandra Iorio, Paola De Simone, Monica Ottaviani, Antonella Del Brocco, Pasquale Frascione, Barbara Bellei
BACKGROUND: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major clinical risk factors for melanoma include fair skin, an increased number of nevi, the presence of dysplastic nevi, and a family history of melanoma. However, several external inducers seem to be associated with melanoma susceptibility such as environmental exposure, primarily unprotected sun experience, alcohol consumption, and heavy metals...
February 21, 2024: Cells
https://read.qxmd.com/read/38474331/comparative-analysis-of-acute-kidney-injury-models-and-related-fibrogenic-responses-convergence-on-methylation-patterns-regulated-by-cold-shock-protein
#29
JOURNAL ARTICLE
Sabine Brandt, Anja Bernhardt, Saskia Häberer, Katharina Wolters, Fabian Gehringer, Charlotte Reichardt, Anna Krause, Robert Geffers, Sascha Kahlfuß, Andreas Jeron, Dunja Bruder, Jonathan A Lindquist, Berend Isermann, Peter R Mertens
BACKGROUND: Fibrosis is characterized by excessive extracellular matrix formation in solid organs, disrupting tissue architecture and function. The Y-box binding protein-1 (YB-1) regulates fibrosis-related genes (e.g., Col1a1 , Mmp2 , and Tgfβ1 ) and contributes significantly to disease progression. This study aims to identify fibrogenic signatures and the underlying signaling pathways modulated by YB-1. METHODS: Transcriptomic changes associated with matrix gene patterns in human chronic kidney diseases and murine acute injury models were analyzed with a focus on known YB-1 targets...
February 20, 2024: Cells
https://read.qxmd.com/read/38474329/the-wnt-co-receptor-ptk7-otk-and-its-homolog-otk-2-in-neurogenesis-and-patterning
#30
JOURNAL ARTICLE
Qian Hui Tan, Agimaa Otgonbaatar, Prameet Kaur, Angelica Faye Ga, Nathan P Harmston, Nicholas S Tolwinski
Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. Wnt ligands can induce disparate cellular responses. The exact mechanism behind these different outcomes is not fully understood but may be due to interactions with different receptors on the cell membrane. PTK7/Otk is a transmembrane receptor that is implicated in various developmental and physiological processes including cell polarity, cell migration, and invasion...
February 20, 2024: Cells
https://read.qxmd.com/read/38474222/antiseptic-functions-of-cgk012-against-hmgb1-mediated-septic-responses
#31
JOURNAL ARTICLE
Yun Jin Park, Jong Beom Heo, Yoon-Jung Choi, Sanghee Cho, Taeho Lee, Gyu Yong Song, Jong-Sup Bae
High mobility group box 1 (HMGB1), a protein with important functions, has been recognized as a potential therapeutic target for the treatment of sepsis. One possible mechanism for this is that inhibiting HMGB1 secretion can exert antiseptic effects, which can restore the integrity of the vascular barrier. (7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester (CGK012) is a newly synthesized pyranocoumarin compound that could function as a novel small-molecule inhibitor of the Wnt/β-catenin signaling pathway...
March 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473817/inorganic-phosphate-induced-extracellular-vesicles-from-vascular-smooth-muscle-cells-contain-elevated-levels-of-hyaluronic-acid-which-enhance-their-interaction-with-very-small-superparamagnetic-iron-oxide-particles
#32
JOURNAL ARTICLE
Christian Freise, Karina Biskup, Véronique Blanchard, Jörg Schnorr, Matthias Taupitz
Patients with chronic kidney disease (CKD) have a high prevalence of hyperphosphatemia, where uremic toxins like inorganic phosphate (Pi) induce a cardiovascular remodeling. Related disorders like atherosclerosis bear the risk of increased morbidity and mortality. We previously found that Pi stimulates the synthesis and sulfation of the negatively charged glycosaminoglycans (GAGs) heparan sulfate and chondroitin sulfate in vascular smooth muscle cells (VSMC). Similar GAG alterations were detected in VSMC-derived exosome-like extracellular vesicles (EV)...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473810/transcriptomic-analysis-reveals-intrinsic-abnormalities-in-endometrial-polyps
#33
JOURNAL ARTICLE
Christine Shan-Chi Chiu, Ling-Yu Yeh, Szu-Hua Pan, Sheng-Hsiang Li
Endometrial polyps (EPs) are benign overgrowths of the endometrial tissue lining the uterus, often causing abnormal bleeding or infertility. This study analyzed gene expression differences between EPs and adjacent endometrial tissue to elucidate intrinsic abnormalities promoting pathological overgrowth. RNA sequencing of 12 pairs of EPs and the surrounding endometrial tissue from infertile women revealed 322 differentially expressed genes. Protein-protein interaction network analysis revealed significant alterations in specific signaling pathways, notably Wnt signaling and vascular smooth muscle regulation, suggesting these pathways play critical roles in the pathophysiology of EPs...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473318/mirna-on-the-battlefield-of-cancer-significance-in-cancer-stem-cells-wnt-pathway-and-treatment
#34
REVIEW
Lekha Bhagtaney, Arun Dharmarajan, Sudha Warrier
Carcinogenesis is a complex process characterized by intricate changes in organ histology, biochemistry, epigenetics, and genetics. Within this intricate landscape, cancer stem cells (CSCs) have emerged as distinct cell types possessing unique attributes that significantly contribute to the pathogenesis of cancer. The WNT signaling pathway plays a critical role in maintaining somatic stem cell pluripotency. However, in cancer, overexpression of WNT mediators enhances the activity of β-catenin, resulting in phenomena such as recurrence and unfavorable survival outcomes...
February 27, 2024: Cancers
https://read.qxmd.com/read/38471284/novel-biomarkers-and-interferon-signature-in-secondary-progressive-multiple-sclerosis
#35
JOURNAL ARTICLE
Avital Fogel, Maya Olcer, Aika Goel, Xuan Feng, Anthony T Reder
Multiple sclerosis (MS) exhibits poor immune regulation and subnormal interferon (IFN-β) signaling. Secondary Progressive MS displays waning exacerbations, relentless neurodegeneration, and diminished benefit of therapy. We find dysregulated serum protein balance (Th1/Th2) and excessive gene expression in Relapsing-Remitting MS vs. healthy controls (8700 differentially-expressed genes, DEG) and intermediate levels in SPMS (3900 DEG). Olfactory receptor genes (chemosensing), and WNT/ß-catenin (anti-inflammatory, repair) and metallothionein (anti-oxidant) gene pathways, have less expression in SPMS than RRMS...
March 6, 2024: Journal of Neuroimmunology
https://read.qxmd.com/read/38470557/sufentanil-suppresses-cell-carcinogenesis-via-targeting-mir-186-5p-hmgb1-axis-and-wnt-%C3%AE-catenin-pathway-in-non-small-cell-lung-cancer
#36
JOURNAL ARTICLE
Di Liu, Ye Huang, You Shang
Sufentanil is a common opioid anesthetic agent, which exerts anti-cancer properties in several cancer types. However, its action mechanisms in non-small cell lung cancer (NSCLC) are unclear. Therefore, the present study investigated the pharmacological effect of sufentanil on miRNAs in NSCLC treatment. In this study, after treatment with sufentanil, the proliferation, migration, invasion and apoptosis of A549 and H1299 NSCLC cell lines were measured by cell counting kit-8 (CCK-8) assay, colony formation assay, transwell assays and flow cytometry...
March 12, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38469899/dkk1-activates-the-pi3k-akt-pathway-via-ckap4-to-balance-the-inhibitory-effect-on-wnt-%C3%AE-catenin-signaling-and-regulates-wnt3a-induced-msc-migration
#37
JOURNAL ARTICLE
Huanhuan Chen, Ya'nan Hu, Xiaojing Xu, Yan Dai, Hongxiang Qian, Xinyu Yang, Jinming Liu, Qisheng He, Huanxiang Zhang
Wnt/β-catenin signaling plays a crucial role in the migration of mesenchymal stem cells (MSCs). However, our study has revealed an intriguing phenomenon where DKK1, an inhibitor of Wnt/β-catenin signaling, promotes MSC migration at certain concentrations ranging from 25 ng/ml to 100 ng/ml, while inhibiting Wnt3a-induced MSC migration at a higher concentration (400 ng/ml). Interestingly, DKK1 consistently inhibited Wnt3a-induced phosphorylation of LRP6 at all concentrations. We further identified CKAP4, another DKK1 receptor, to be localized on the cell membrane of MSCs...
March 12, 2024: Stem Cells
https://read.qxmd.com/read/38468952/gtp-binding-protein-2-maintains-the-quiescence-self-renewal-and-chemoresistance-of-mouse-colorectal-cancer-stem-cells-via-promoting-wnt-signaling-activation
#38
JOURNAL ARTICLE
Chao Ke, Hongjian Zhou, Tian Xia, Xingwang Xie, Bin Jiang
Colorectal cancer (CRC) is one of the most common cancers and the second most deadly cancer across the globe. Colorectal cancer stem cells (CCSCs) fuel CRC growth, metastasis, relapse, and chemoresistance. A complete understanding of the modulatory mechanisms of CCSC biology is essential for developing efficacious CRC treatment. In the current study, we characterized the expression and function of GTP binding protein 2 (GTPBP2) in a chemical-induced mouse CRC model. We found that GTPBP2 was expressed at a higher level in CD133+ CD44+ CCSCs compared with other CRC cells...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38468521/tp508-promotes-bone-regeneration-on-distraction-osteogenesis-via-the-activation-of-wnt-%C3%AE-catenin-signaling-pathway
#39
JOURNAL ARTICLE
Kehan Li, Linan Liu, Jingyi Zhang, Chenyu Liao, Jian Hu, Jian Song
INTRODUCTION: TP508 is a thrombin peptide that participates in the inflammatory response and wound healing. Its role in the molecular mechanism of distraction osteogenesis remains unclear. This study established a tibia distraction osteogenesis (DO) model in rats and investigated the role and mechanism of TP508 in bone regeneration during DO. METHOD: Micro-computed tomography (Micro-CT) and hematoxylin-eosin (HE) staining were used to track osteogenesis. Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to measure the expression of osteoblast-related factors, Wnt/β- catenin signaling-related proteins and genes...
March 11, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38465946/strategy
#40
JOURNAL ARTICLE
Fabian Trillsch, Juliane Reichenbach, Bastian Czogalla, Fabian Kraus, Alexander Burges, Sven Mahner, Mirjana Kessler
While the establishment of an ovarian cancer biobank from patient-derived organoids along with their clinical background information promises advances in research and patient care, standardization remains a challenge due to the heterogeneity of this lethal malignancy, combined with the inherent complexity of organoid technology. This adaptable protocol provides a systematic framework to realize the full potential of ovarian cancer organoids considering a patient-specific variability of progenitors. By implementing a structured experimental workflow to select optimal culture conditions and seeding methods, with parallel testing of direct 3D seeding versus a 2D/3D route, we obtain, in most cases, robust long-term expanding lines suitable for a broad range of downstream applications...
February 23, 2024: Journal of Visualized Experiments: JoVE
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