keyword
https://read.qxmd.com/read/38492821/mutational-profile-evaluates-metastatic-capacity-of-chinese-colorectal-cancer-patients-revealed-by-whole-exome-sequencing
#1
JOURNAL ARTICLE
Yian Yang, Jiawei Chen, Honghua Peng, Zhigang Xiao, Wei Xu, Mingchuan Zheng, Zheng Li, Peiguo Cao
Colorectal cancer (CRC) is the third most common cancer and the prevalence rate of CRC is increasing in the China. In this study, whole-exome sequencing (WES) was performed on primary tissues of 47 CRC Chinese patients including 22 metastatic and 25 non-metastatic patients. By comparison with data from western colorectal cancer patients in the Cancer Genome Atlas (TCGA), we identified a number of genes that are more likely to be mutated in Chinese colorectal cancer patients, such as MUC12, MUC12, MUC2, MUC4, HYDIN and KMT2C...
March 14, 2024: Genomics
https://read.qxmd.com/read/38491522/endothelial-%C3%AE-catenin-upregulation-and-y142-phosphorylation-drive-diabetic-angiogenesis-via-upregulating-kdr-hdac9
#2
JOURNAL ARTICLE
Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo
BACKGROUND: Diabetic angiogenesis is closely associated with disabilities and death caused by diabetic microvascular complications. Advanced glycation end products (AGEs) are abnormally accumulated in diabetic patients and are a key pathogenic factor for diabetic angiogenesis. The present study focuses on understanding the mechanisms underlying diabetic angiogenesis and identifying therapeutic targets based on these mechanisms. METHODS: In this study, AGE-induced angiogenesis serves as a model to investigate the mechanisms underlying diabetic angiogensis...
March 15, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38491161/notoginsenoside-r1-promotes-lgr5-stem-cell-and-epithelium-renovation-in-colitis-mice-via-activating-wnt-%C3%AE-catenin-signaling
#3
JOURNAL ARTICLE
Zhi-Lun Yu, Rui-Yang Gao, Cheng Lv, Xiao-Long Geng, Yi-Jing Ren, Jing Zhang, Jun-Yu Ren, Hao Wang, Fang-Bin Ai, Zi-Yi Wang, Bei-Bei Zhang, Dong-Hui Liu, Bei Yue, Zheng-Tao Wang, Wei Dou
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily address inflammation, neglecting epithelial repair. Our previous study has reported the therapeutic potential of notoginsenoside R1 (NGR1), a characteristic saponin from the root of Panax notoginseng, in alleviating acute colitis by reducing mucosal inflammation. In this study we investigated the reparative effects of NGR1 on mucosal barrier damage after the acute injury stage of DSS exposure...
March 15, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38491087/author-correction-characterization-of-wnt-signaling-pathway-under-treatment-of-lactobacillus-acidophilus-postbiotic-in-colorectal-cancer-using-an-integrated-in-silico-and-in-vitro-analysis
#4
Nafiseh Erfanian, Saeed Nasseri, Adib Miraki Feriz, Hossein Safarpour, Mohammad Hassan Namaei
No abstract text is available yet for this article.
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490518/the-involvement-of-the-wnt-%C3%AE-catenin-signaling-cascade-in-fibrosis-progression-and-its-therapeutic-targeting-by-relaxin
#5
REVIEW
Deidree V N Somanader, Peishen Zhao, Robert E Widdop, Chrishan S Samuel
Organ scarring, referred to as fibrosis, results from a failed wound-healing response to chronic tissue injury and is characterised by the aberrant accumulation of various extracellular matrix (ECM) components. Once established, fibrosis is recognised as a hallmark of stiffened and dysfunctional tissues, hence, various fibrosis-related diseases collectively contribute to high morbidity and mortality in developed countries. Despite this, these diseases are ineffectively treated by currently-available medications...
March 13, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38490099/cancer-stem-cells-the-important-role-of-cd-markers-signaling-pathways-and-micrornas
#6
REVIEW
Amir Gholamzad, Niloofar Khakpour, Elaheh Mohandesi Khosroshahi, Saba Asadi, Zeinab Khazaei Koohpar, Arash Matinahmadi, Ali Jebali, Mohsen Rashidi, Mehrdad Hashemi, Farzaneh Hasani Sadi, Mehrdad Gholamzad
For the first time, a subset of small cancer cells identified in acute myeloid leukemia has been termed Cancer Stem Cells (CSCs). These cells are notorious for their robust proliferation, self-renewal abilities, significant tumor-forming potential, spread, and resistance to treatments. CSCs are a global concern, as it found in numerous types of cancer, posing a real-world challenge today. Our review encompasses research on key CSC markers, signaling pathways, and MicroRNA in three types of cancer: breast, colon, and liver...
February 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38488028/pigment-epithelium%C3%A2-derived-factor-inhibits-proliferation-invasion-and-angiogenesis-and-induces-ferroptosis-of-extravillous-trophoblasts-by-targeting-wnt%C3%A2-%C3%AE-%C3%A2-catenin-vegf-signaling%C3%A2-in-placenta-accreta-spectrum
#7
JOURNAL ARTICLE
Rui Li, Xiaoying Weng, Xuyang Hu, Junjun Wang, Lin Zheng
Placenta accreta spectrum (PAS) is one of the most dangerous complications in obstetrics, which can lead to severe postpartum bleeding and shock, and even necessitate uterine removal. The abnormal migration and invasion of extravillous trophoblast cells (EVTs) and enhanced neovascularization occurring in an uncontrolled manner in time and space are closely related to the abnormal expression of pro‑angiogenic and anti‑angiogenic factors. The pigment epithelium‑derived factor (PEDF) is a multifunctional regulatory factor that participates in several important biological processes and is recognized as the most efficient inhibitor of angiogenesis...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38488003/the-cholesterol-biosynthesis-enzyme-faxdc2-couples-wnt-%C3%AE-catenin-to-rtk-mapk-signaling
#8
JOURNAL ARTICLE
Babita Madan, Shawn R Wadia, Siddhi Patnaik, Nathan Harmston, Emile Tan, Iain Bee Huat Tan, W David Nes, Enrico Petretto, David M Virshup
Wnts, cholesterol, and MAPK signaling are essential for development and adult homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a previously uncharacterized enzyme, functions as a methyl sterol oxidase catalyzing C4 demethylation in the Kandutsch-Russell branch of the cholesterol biosynthesis pathway. FAXDC2, a paralog of MSMO1, regulated the abundance of the specific C4-methyl sterols lophenol and dihydro-T-MAS. Highlighting its clinical relevance, FAXDC2 was repressed in Wnt/β-catenin-high cancer xenografts, in a mouse genetic model of Wnt activation, and in human colorectal cancers...
January 23, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38487345/research-progress-of-periostin-and-osteoporosis
#9
REVIEW
Chuyue Yuan, Junyan Li
Periostin, as a unique extracellular matrix, is mainly produced during ontogeny and in adult connective tissues that bear mechanical loads, such as heart valves, skin, periodontal ligaments, tendons, and bones. By binding to the integrin on the cell surface and activating Wnt/β-catenin, NF-κB, Fak and other signaling pathways, it regulates the tissues in vivo positively or negatively, and also has different effects on the occurrence and development of various diseases. Periostin is an important factor, which can promote cell proliferation, stimulate tissue repair and maintain the integrity of the structure and function of connective tissue...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38487172/a-comprehensive-evaluation-of-the-therapeutic-potential-of-silibinin-a-ray-of-hope-in-cancer-treatment
#10
REVIEW
Pantha Prodip Ray, Mohammad Ashraful Islam, Mohammad Safiqul Islam, Aixia Han, Peiwu Geng, Md Abdul Aziz, Abdullah Al Mamun
Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong anti-cancer activity against several types of human cancers based on emerging research. This study aims to provide an overview of the therapeutic potential of silibinin in the treatment and prevention of cancers...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38487006/sulfation-of-chondroitin-and-bile-acids-converges-to-antagonize-wnt-%C3%AE-catenin-signaling-and-inhibit-apc-deficiency-induced-gut-tumorigenesis
#11
JOURNAL ARTICLE
Pengfei Xu, Yue Xi, Jong-Won Kim, Junjie Zhu, Min Zhang, Meishu Xu, Songrong Ren, Da Yang, Xiaochao Ma, Wen Xie
Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology. 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the primary enzyme to generate the universal sulfonate donor PAPS. The involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli (APC) mutation-promoted colonic carcinogenesis has not been reported. Here, we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages, and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon cancer...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38486356/comprehensive-transcriptional-atlas-of-human-adenomyosis-deciphered-by-the-integration-of-single-cell-rna-sequencing-and-spatial-transcriptomics
#12
JOURNAL ARTICLE
Tao Chen, Yiliang Xu, Xiaocui Xu, Jianzhang Wang, Zhiruo Qiu, Yayuan Yu, Xiaohong Jiang, Wanqi Shao, Dandan Bai, Mingzhu Wang, Shuyan Mei, Tao Cheng, Li Wu, Shaorong Gao, Xuan Che
Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding "invagination" and "metaplasia" theories. The endometrial-myometrial junction (EMJ) connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis, but its in-depth study is just beginning. Using single-cell RNA sequencing and spatial profiling, we mapped transcriptional alterations across eutopic endometrium, lesions, and EMJ. Within lesions, we identified unique epithelial (LGR5+) and invasive stromal (PKIB+) subpopulations, along with WFDC1+ progenitor cells, supporting a complex interplay between "invagination" and "metaplasia" theories of pathogenesis...
March 15, 2024: Protein & Cell
https://read.qxmd.com/read/38486234/ubiquitin-ligase-subunit-fbxo9-inhibits-v-atpase-assembly-and-impedes-lung-cancer-metastasis
#13
JOURNAL ARTICLE
Liang Liu, Xiaodong Chen, Leilei Wu, Kaizong Huang, Zhenyi Wang, Yaolin Zheng, Cheng Zheng, Zhenshan Zhang, Jiayan Chen, Jiaming Wei, Song Chen, Weilin Jin, Jinfei Chen, Dongping Wei, Yaping Xu
BACKGROUND: The evolutionarily conserved protein FBXO9 acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase and is implicated in cancer, exhibiting either tumor-suppressive or oncogenic effects depending on the specific tumor type. However, their role in lung cancer metastasis remains unclear. METHODS: Lentiviral vectors carrying miRNA-based shRNA sequences for gene-specific knockdown were generated, and Lenti-CRISPR-Cas9 vectors containing gene-specific sgRNA sequences were designed...
March 14, 2024: Experimental Hematology & Oncology
https://read.qxmd.com/read/38484850/securinine-inhibits-the-tumor-growth-of-human-bladder-cancer-cells-by-suppressing-wnt-%C3%AE-catenin-signaling-pathway-and-activating-p38-and-jnk-signaling-pathways
#14
JOURNAL ARTICLE
Liping Xie, Shiqiong Liang, Habu Jiwa, Lulu Zhang, Qiuping Lu, Xiaoxuan Wang, Lijuan Luo, Haichao Xia, Ziyun Li, Jiayu Wang, Xiaoji Luo, Jinyong Luo
Bladder cancer (BC) is the most common malignant tumor in urinary system. Although chemotherapy is one of the most important adjuvant treatments for BC, drug resistance, non-specific toxicity and severe side effects are the major obstacles to BC chemotherapy. Natural products have always been a leading resource of antitumor drug discovery, with the advantages of excellent effectiveness, low toxicity, multi-targeting potency and easy availability. In this study, we evaluated the potential anti-tumor effect of securinine (SEC), a natural alkaloid from Securinega suffruticosa, on BC cells in vitro and in vivo, and delineated the underlying mechanism...
March 12, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38483903/blmp-1-is-a-critical-temporal-regulator-of-dietary-restriction-induced-response-in-caenorhabditis-elegans
#15
JOURNAL ARTICLE
Qingyuan Hu, Yunpeng Xu, Mengjiao Song, Yumin Dai, Adam Antebi, Yidong Shen
The extrinsic diet and the intrinsic developmental programs are intertwined. Although extensive research has been conducted on how nutrition regulates development, whether and how developmental programs control the timing of nutritional responses remain barely known. Here, we report that a developmental timing regulator, BLMP-1/BLIMP1, governs the temporal response to dietary restriction (DR). At the end of larval development, BLMP-1 is induced and interacts with DR-activated PHA-4/FOXA, a key transcription factor responding to the reduced nutrition...
March 12, 2024: Cell Reports
https://read.qxmd.com/read/38480605/mir-575-ripk4-axis-modulates-cell-cycle-progression-and-proliferation-by-inactivating-the-wnt-%C3%AE-catenin-signaling-pathway-through-inhibiting-runx1-in-colon-cancer
#16
JOURNAL ARTICLE
Qun Wang, Weijun Lu, Li Lu, Ruopu Wu, Dongde Wu
Receptor interacting protein serine/threonine kinase 4 (RIPK4) is widely involved in human cancer development. Nevertheless, its role in colon cancer (COAD) has not been elucidated till now. Our research aimed at exploring the function and underlying molecular mechanism of RIPK4 in COAD progression. Through bioinformatic analyses and RT-qPCR, RIPK4 was discovered to be increased in COAD cells and tissues, and its high level predicted poor prognosis. Loss-of-function assays revealed that RIPK4 silencing suppressed COAD cell growth, induced cell cycle arrest, and enhanced cell apoptosis...
March 14, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38480585/genetic-factors-underlying-host-resistance-to-rhipicephalus-microplus-tick-infestation-in-braford-cattle-a-systems-biology-perspective
#17
JOURNAL ARTICLE
Wanessa A Carvalho, Emanuelle B Gaspar, Robert Domingues, Luciana C A Regitano, Fernando F Cardoso
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus (Boophilus) microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts...
March 13, 2024: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://read.qxmd.com/read/38480001/phloroglucinol-enhances-anagen-signaling-and-alleviates-h-2-o-2-induced-oxidative-stress-in-human-dermal-papilla-cells
#18
JOURNAL ARTICLE
Seokmuk Park, Ye Jin Lim, Hee Su Kim, Hee-Jae Shin, Ji-Seon Kim, Jae Nam Lee, Jae Ho Lee, Seunghee Bae
Phloroglucinol (PG) is one of the abundant isomeric benzenetriols in brown algae. Due to its polyphenolic structure, PG exhibits various biological activities. However, the impact of PG on anagen signaling and oxidative stress in human dermal papilla cells (HDPCs) is unknown. In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling...
March 8, 2024: Journal of Microbiology and Biotechnology
https://read.qxmd.com/read/38478616/the-%C3%AE-catenin-c-terminus-links-wnt-and-sphingosine-1-phosphate-signaling-pathways-to-promote-vascular-remodeling-and-atherosclerosis
#19
JOURNAL ARTICLE
Gustavo H Oliveira-Paula, Sophia Liu, Alishba Maira, Gaia Ressa, Graziele C Ferreira, Amado Quintar, Smitha Jayakumar, Vanessa Almonte, Dippal Parikh, Tomas Valenta, Konrad Basler, Timothy Hla, Dario F Riascos-Bernal, Nicholas E S Sibinga
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β-catenin-S1P cross-talk. In the vascular system, both Wnt/β-catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β-catenin...
March 15, 2024: Science Advances
https://read.qxmd.com/read/38478327/blood-based-microrna-profiling-unveils-complex-molecular-dynamics-in-breast-cancer
#20
JOURNAL ARTICLE
Mudassar Shahid, Rabbani Syed, M A Ansari, Gowher Shafi, James John
BACKGROUND: Breast cancer, a genetically intricate disease with diverse subtypes, exhibits heightened incidence globally. In this study, we aimed to investigate blood-based microRNAs (miRNAs) as potential biomarkers for breast cancer. The primary objectives were to explore the role of miRNAs in cancer-related processes, assess their differential expression between breast cancer patients and healthy individuals, and contribute to a deeper understanding of the molecular underpinnings of breast cancer...
March 13, 2024: Journal of Applied Genetics
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