keyword
MENU ▼
Read by QxMD icon Read
search

Activator method

keyword
https://www.readbyqxmd.com/read/29334704/-status-and-related-factors-for-gestational-weight-gain-of-chinese-pregnant-women-during-2010-2012
#1
Y Bi, Y F Duan, J Wang, S Jiang, X H Pang, S A Yin, Z Y Yang, J Q Lai
Objective: To examine the status and related factors for gestational weight gain of Chinese pregnant women at different trimesters in 2010-2012. Methods: Participants were from Chinese National Nutrition and Health Surveillance in 2010-2012. Using a multi-stage stratified cluster random sampling method, we recruited 2 805 singleton pregnant women with gestational age 13 weeks or more from 31 provinces of China. A standard questionnaire was used to collect general information and pre-pregnancy weight; body weight and height of pregnant women were measured using a unified weighing scale and stadiometer, dietary intake during the previous year was collected using a food frequency questionnaire...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334702/-prevalence-of-calf-muscle-cramps-and-influencing-factors-for-pregnant-women-in-china-during-2010-2012
#2
Y F Duan, J Wang, S Jiang, Y Bi, X H Pang, S A Yin, Z Y Yang
Objective: To investigate the prevalence of calf muscle cramps and possible influencing factors for pregnant women in China. Methods: Using a multi-stage stratified probability proportional to size cluster randomization sampling method during 2010-2012. A total of 3 582 pregnant women were investigated at 150 counties from 31 provinces in China mainland. Information on calf muscle cramps, demographic socio-economic status, pregnancy information, and the physical activities was collected through questionnaires...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334637/contamination-characteristics-and-source-apportionment-of-heavy-metals-in-topsoil-from-an-area-in-xi-an-city-china
#3
Xiuduan Chen, Xinwei Lu
As soil-extractable elements potentially pose ecological and health risks, identifying their contamination characteristics and sources is crucial. Therefore, to understand topsoil trace elements in the urban ring zone from the Second Ring Road to the Third Ring of Xi'an city in China, we determined the concentrations of Zn, Co, V, As, Cu, Mn, Ba, Ni and Pb, and analyzed the sources of the contamination. The results showed that the individual pollution indices of Pb, Co, Cu, Zn, Ba, Ni, Mn, As, and V were 1...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29334584/in-vitro-and-in-vivo-metabolite-identification-of-a-novel-benzimidazole-compound-zln005-by-lc-ms-ms
#4
Wenchao Sun, Khoa Dinh Nguyen, William L Fitch, Samuel D Banister, Hongxiang Tang, Xiaolan Zhang, Lewis Yu, Edgar G Engleman, Jayakumar Rajadas
RATIONALE: A novel benzimidazole compound ZLN005 was previously identified as a transcriptional activator of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in certain metabolic tissues. Upregulation of PGC-1α by ZLN005 has been shown to have beneficial effect in a diabetic mouse model and in a coronary artery disease model in vitro. ZLN005 could also have therapeutic potential in neurodegenerative diseases involving down-regulation of PGC-1α. Given the phenotypic efficacy of ZLN005 in several animal models of human disease, its metabolic profile was investigated to guide the development of novel therapeutics using ZLN005 as the lead compound...
January 15, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29334572/assessment-of-parasympathetic-activity-in-athletes-comparing-two-different-methods-retraction
#5
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29334511/evaluation-of-recombinant-factor-viia-tranexamic-acid-and-desmopressin-to-reduce-prasugrel-related-bleeding-a-randomised-placebo-controlled-study-in-a-rabbit-model
#6
Fanny Bonhomme, Thomas Lecompte, Charles M Samama, Anne Godier, Pierre Fontana
BACKGROUND: Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE: The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs - recombinant activated factor VII (rFVIIa), tranexamic acid and desmopressin (DDAVP) - to limit blood loss after administration of prasugrel in a rabbit model of bleeding while also evaluating any prothrombotic effects...
January 13, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29334506/targeted-biopsy-benefits-and-limitations
#7
Stephanie Purnell, Jonathan Bloom, Vladimir Valera Romero, Bradford Wood, Ismail Baris Turkbey, Peter A Pinto
PURPOSE OF REVIEW: To review the current literature regarding the role of multiparametric MRI and fusion-guided biopsies in urologic practice. RECENT FINDINGS: Fusion biopsies consistently show an increase in the detection of clinically significant cancers and decrease in low-risk disease that may be more suitable for active surveillance. Although, when to incorporate multiparametric MRI into workup is not clearly agreed upon, studies have shown a clear benefit in both biopsy naïve and those with prior negative biopsies in determining the appropriate treatment strategy...
January 13, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29334458/direct-electrochemical-vibrio-dna-sensing-adopting-highly-stable-graphene-flavin-mononucleotide-aqueous-dispersion-modified-interface
#8
Tao Yang, Huaiyin Chen, Zhiwei Qiu, Renzhong Yu, Shizhong Luo, Weihua Li, Kui Jiao
A bio-functionalized graphene nanohybrid was prepared by simultaneously sonicating graphene and riboflavin 5'-monophosphate sodium salt (FMNS). FMNS, as a bio-dispersant, shows an efficient stabilization for obtaining highly dispersed graphene nanosheets in an aqueous solution. Due to the superior dispersion of graphene and the excellent electrochemical redox activity of FMNS, a direct electrochemical DNA sensor was fabricated adopting the inherent electrochemical redox activity of Gr-FMNS. The comparison between using traditional electrochemical indicator ([Fe(CN)6]3-/4-) and using the self-signal of Gr-FMNS was fully conducted to study the DNA sensing performance...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29334383/a-simple-method-for-determining-the-ligand-affinity-toward-a-zinc-enzyme-model-by-using-a-tamra-tamra-interaction
#9
Hiroshi Kusamoto, Akio Shiba, Masaya Tsunehiro, Haruto Fujioka, Emiko Kinoshita-Kikuta, Eiji Kinoshita, Tohru Koike
Thiolate coordination to zinc(ii) ions occurs widely in such functional biomolecules as zinc enzymes or zinc finger proteins. Here, we introduce a simple method for determining the affinity of ligands toward the zinc-enzyme active-center model tetramethylrhodamine (TAMRA)-labeled 1,4,7,10-tetraazacyclododecane (cyclen)-zinc(ii) complex (TAMRA-ZnL). The 1 : 1 complexation of TAMRA-labeled cysteine (TAMRA-Cys) with TAMRA-ZnL (each at 2.5 μM), in which the TAMRA moieties approach one another closely, induces remarkable changes in the visible absorption and fluorescence spectra at pH 7...
January 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29334380/light-activated-chemical-probing-of-nucleobase-solvent-accessibility-inside-cells
#10
Chao Feng, Dalen Chan, Jojo Joseph, Mikko Muuronen, William H Coldren, Nan Dai, Ivan R Corrêa, Filipp Furche, Christopher M Hadad, Robert C Spitale
The discovery of functional RNAs that are critical for normal and disease physiology continues to expand at a breakneck pace. Many RNA functions are controlled by the formation of specific structures, and an understanding of each structural component is necessary to elucidate its function. Measuring solvent accessibility intracellularly with experimental ease is an unmet need in the field. Here, we present a novel method for probing nucleobase solvent accessibility, Light Activated Structural Examination of RNA (LASER)...
January 15, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29334369/dual-gene-activation-and-knockout-screen-reveals-directional-dependencies-in-genetic-networks
#11
Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner, David Wu, Xiulei Mo, Anne Biton, Noah Zaitlen, Haian Fu, Frank McCormick, Martin Kampmann, Michael T McManus
Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins from Streptococcus pyogenes and Staphylococcus aureus to carry out a dual screen in which one gene is activated while a second gene is deleted in the same cell. We analyze the quantitative effects of activation and knockout to calculate genetic interaction and directionality scores for each gene pair...
January 15, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29334339/impact-of-spasticity-on-transfers-and-activities-of-daily-living-in-individuals-with-spinal-cord-injury
#12
Jacqueline Tibbett, Eva G Widerström-Noga, Christine K Thomas, Edelle C Field-Fote
CONTEXT/OBJECTIVE: For persons with spinal cord injury, spasticity commonly interferes with activities of daily living such as transfers. Electromyography can be used to objectively measure muscle spasms during transfers, but how electromyographic measures relate to the impact spasticity has on life, or to clinically-rated spasticity, is unclear. We aimed to characterize relationships among spasm duration and magnitude, impact of spasticity on daily life, and a clinical measure of extensor spasticity, as well as to determine reliability of the electromyographic measures...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29334331/transport-mobility-5%C3%A2-years-after-stroke-in-an-urban-setting
#13
Hanna C Persson, Helena Selander
Background People after stroke may have residual problems with mobility that can affect their independence and mode of transport. However, there is limited knowledge about transport mobility several years after stroke. Objective The objective was to survey the outdoor mobility and transportation in an urban setting five years post-stroke. Method This cross-sectional study was based on a mail survey focusing on long-term consequences after stroke. The survey comprises a set of self-evaluated questionnaires and was sent to 457 persons, of whom 281 responded (61...
January 15, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29334325/concurrent-validity-and-reliability-of-torso-worn-inertial-measurement-unit-for-jump-power-and-height-estimation
#14
Timo Rantalainen, Paul B Gastin, Rhys Spangler, Daniel Wundersitz
The purpose of the present study was to evaluate the concurrent validity and test-retest repeatability of torso-worn IMU-derived power and jump height in a counter-movement jump test. Twenty-seven healthy recreationally active males (age, 21.9 [SD 2.0] y, height, 1.76 [0.7] m, mass, 73.7 [10.3] kg) wore an IMU and completed three counter-movement jumps a week apart. A force platform and a 3D motion analysis system were used to concurrently measure the jumps and subsequently derive power and jump height (based on take-off velocity and flight time)...
January 15, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29334264/antifungal-activity-of-phenolic-monoterpenes-and-structure-related-compounds-against-plant-pathogenic-fungi
#15
Kaibo Wang, Shanshan Jiang, Te Pu, Liming Fan, Fawu Su, Min Ye
The aim of this work is to explore the possibility of using the phenolic monoterpenes (PMs) as leading compounds with antifungal activity against plant disease. The in vitro antifungal activities of carvacrol and thymol against seven kinds of plant pathogenic fungi were evaluated on mycelium growth rate method, and the results showed that carvacrol and thymol exhibited broad spectrum antifungal activity. Structure requirement for the antifungal activity of PMs was also investigated. The preliminary conclusion was that phenolic hydroxyl and monoterpene were basic structures for the antifungal activity of PMs, and the position of phenolic hydroxyl showed less effect...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334247/development-of-fisetin-loaded-folate-functionalized-pluronic-micelles-for-breast-cancer-targeting
#16
Atmaram Pawar, Srishti Singh, S Rajalakshmi, Karimunnisa Shaikh, C Bothiraja
The natural flavonoid fisetin (FS) has shown anticancer properties but its in-vivo administration remains challenging due to its poor aqueous solubility. The aim of the study was to develop FS loaded pluronic127 (PF)-folic acid (FA) conjugated micelles (FS-PF-FA) by the way of increasing solubility, bioavailability and active targetability of FS shall increase its therapeutic efficacy. FA-conjugated PF was prepared by carbodiimide crosslinker chemistry. FS-PF-FA micelles were prepared by thin-film hydration method and evaluated in comparison with free FS and FS loaded PF micelles (FS-PF)...
January 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29334246/screening-of-north-east-mexico-medicinal-plants-with-activities-against-herpes-simplex-virus-and-human-cancer-cell-line
#17
David Silva-Mares, Veronica M Rivas-Galindo, Ricardo Salazar-Aranda, Luis Alejandro Pérez-Lopez, Noemí Waksman De Torres, Jonathan Pérez-Meseguer, Ernesto Torres-Lopez
The plants examined in this study have previous biological activity reports indicating the possibility of found activity against herpes and cancer cell. The aim of this contribution was to carry out a screening of Juglans mollis (Juglandaceae), Persea americana (Lauraceae), Hamelia patens (Rubiaceae), Salvia texana (Lamiaceae), Salvia ballotaeflora (Lamiaceae), Ceanothus coeruleus (Rhamnaceae), Chrysactinia mexicana (Asteraceae) y Clematis drummondii (Ranunculaceae), against HeLa cells, VHS-1 and VHS-2. The method MTT was used to determine the 50% cytotoxic concentration (CC50), in Vero and HeLa cell lines...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334179/functionalized-nanoparticles-efficiently-enhancing-the-targeted-delivery-tumor-penetration-and-anticancer-activity-of-7-ethyl-10-hydroxycamptothecin
#18
Xun Liu, Jingxing Si, Qianzhi Zhang, Qian Huang, Danxia Gu, Hao Yang, Xu Chen, Youqing Shen, Meihua Sui
The enhanced permeability and retention (EPR) effect of tumors is much more complex than initially defined, and it alone is not sufficient for targeted delivery of nanosized agents. Meanwhile, poor tumor penetration is another major challenge for the treatment of solid tumors using nanoparticles. Development of delivery systems for SN38, the active metabolite of CPT-11 in human and a very potent anticancer molecule, has become an attractive research area. PEGx -p(HEMASN38)y (x and y are viable), a prodrug synthesized by using polyethylene glycol (PEG) as initiator and SN38 as monomer through atom transfer radical polymeration (ATRP) method, is previously reported...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334123/cancer-associated-fibroblasts-tailored-tumor-microenvironment-of-therapy-resistance-in-gastrointestinal-cancers
#19
REVIEW
Yeqi Sun, Ruifen Wang, Meng Qiao, Yanchun Xu, Wenbin Guan, Lifeng Wang
Gastrointestinal cancers (GI) are a group of highly aggressive malignancies with heavy cancer-related mortalities. Even if continued development of therapy methods, therapy resistance has been a great obstruction for cancer treatment and thereby inevitably leads to depressed final mortality. Peritumoral cancer associated fibroblasts (CAFs), a versatile population assisting cancer cells to build a facilitated tumor microenvironment (TME), has been demonstrated exerting a promotion influence on cancer proliferation, migration, invasion, metastasis and also therapy resistance...
January 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29334115/label-free-multidimensional-information-acquisition-from-optogenetically-engineered-cells-using-a-graphene-transistor
#20
Gongxin Li, Jia Yang, Wenguang Yang, Feifei Wang, Yuechao Wang, Wenxue Wang, Lianqing Liu
The optogenetic technique, which allows the manipulation of cellular activity patterns in space and time by light, has transformed the field of neuroscience. However, acquiring multidimensional optogenetic information remains challenging despite the fact that several cellular information detection methods have been proposed. Herein, we present a new method to acquire label-free multidimensional information from optogenetically engineered cells using a graphene transistor. Using a graphene film to form a strong densely packed layer with cells, the cellular action potentials were characterized as light-activated transistor conductance signals, which quantified the multidimensional optogenetic information...
January 15, 2018: Nanoscale
keyword
keyword
89818
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"