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https://www.readbyqxmd.com/read/28454485/cheminformatics-based-anticoagulant-study-of-traditionally-used-medicinal-plants
#1
Mahdi Alikhani Pour, Soroush Sardari, Ali Eslamifar, Abid Azhar, Mohammad Rezvani, Milad Nazari
Backgroung: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. Methods: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists...
April 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28454479/in-situ-immobilization-on-the-silica-gel-surface-and-adsorption-capacity-of-poly-n-4-carboxyphenyl-methacrylamide-on-toxic-metal-ions
#2
Elina Yanovska, Irina Savchenko, Dariusz Sternik, Olga Kychkiruk, Lidiya Ol'khovik, Iana Buriachenko
In situ immobilization of poly[N-(4-carboxyphenyl)methacrylamide] has been performed on silica gel surface. Infrared (IR) and mass spectroscopies as well as thermogravimetry (TG) analysis have been used to elucidate the structure of immobilized polymer. An adsorption capacity of the synthesized composite towards Cu(II), Pb(II), Mn(II), Fe(III), Co(II), and Ni(II) ions has been estimated. Adsorption activity to microquantities of Pb(II), Cu(II), and Ni(II) in a neutral aqueous medium has been observed.
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454476/parp-inhibition-sensitizes-endometrial-cancer-cells-to-paclitaxel-induced-apoptosis
#3
Christine Dinkic, Friederike Jahn, Marek Zygmunt, Florian Schuetz, Joachim Rom, Christof Sohn, Herbert Fluhr
PARP inhibitors are used in the treatment of gynecological malignancies and it has been demonstrated in preclinical studies that PARP inhibition sensitizes cancer cells to cytotoxic agents. In the present study, PARP expression was detected in different endometrial cancer cell lines by western blot analysis, and PARP activity was measured using an enzymatic assay. In addition, the endometrial cancer cell lines were treated with paclitaxel or carboplatin in combination with the PARP inhibitor PJ34 prior to a cell viability assay and apoptotic nuclei measurement...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454475/oridonin-induces-g2-m-cell-cycle-arrest-and-apoptosis-via-the-pi3k-akt-signaling-pathway-in-hormone-independent-prostate-cancer-cells
#4
Jianlei Lu, Xiang Chen, Shuang Qu, Bing Yao, Yuexin Xu, Jiahui Wu, Yucui Jin, Changyan Ma
Oridonin is an active constituent isolated from the traditional Chinese herb Rabdosia rubescens, which exerts antitumor effects in experimental and clinical settings. However, its antitumor effects and underlying mechanisms on prostate cancer cells have not yet been clearly identified. In the present study, the androgen-independent prostate cancer PC3 and DU145 cell lines were used as models to investigate the effects and possible mechanisms of oridonin on cellular proliferation and apoptosis. Results demonstrated that oridonin inhibited cellular proliferation, and was able to significantly induce G2/M cell cycle arrest and apoptosis...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454472/hsp90-inhibitor-sy-016-induces-g2-m-arrest-and-apoptosis-in-paclitaxel-resistant-human-ovarian-cancer-cells
#5
Hyun Gyo Lee, Won Jin Park, So Jin Shin, Sang Hoon Kwon, Soon Do Cha, Young Ho Seo, Ju Hui Jeong, Ji Yoon Lee, Chi Heum Cho
The aim of the present study was to evaluate the in vitro effect of a heat shock protein (Hsp)90 inhibitor, SY-016, on the paclitaxel (PTX)-resistant human ovarian cancer cell line OVCAR-3PTX, and explore its mechanism of apoptosis. In the present study, SY-016 was used in combination with PTX to determine its effect on the cell proliferation and apoptosis of OVCAR-3PTX cells. The drug-resistant tumor cells were established in vitro by stepwise sequential exposure to increasing concentrations of PTX. The cell viability and cell cycle distribution were measured by MTT assay and flow cytometric analysis, respectively...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454469/regulation-of-cytotoxicity-and-apoptosis-associated-pathways-contributes-to-the-enhancement-of-efficacy-of-cisplatin-by-baicalein-adjuvant-in-human-a549-lung-cancer-cells
#6
Suparata Kiartivich, Ying Wei, Jiaqi Liu, Rungtip Soiampornkul, Mihui Li, Hongying Zhang, Jingcheng Dong
Scutellaria baicalensis (SB; Chinese name, huangqin) is widely used in Chinese medicine as a traditional adjuvant in the chemotherapy of lung and liver cancer. Baicalein is one of the bioactive flavonoid components isolated from the root of SB. The present study aimed to observe the effect of baicalein, in combination with platin-based systemic chemotherapy (cisplatin), on cytotoxicity and apoptosis of human A549 lung cancer cells. The cell cultures were treated with baicalein, cisplatin, or a combination of the two...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454468/ethanolic-extract-of-thevetia-peruviana-flowers-enhances-tnf-%C3%AE-and-trail-induced-apoptosis-of-human-cervical-cancer-cells-via-intrinsic-and-extrinsic-pathways
#7
Chittima Managit, Hiroaki Sakurai, Ikuo Saiki
Tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) are promising candidates for cancer treatment due to their ability to induce apoptosis through death receptor stimulation. However, their usage may be limited due to the resistance of cancer cells to TNF-α- and TRAIL-induced apoptosis. Currently, there is interest in screening for natural products that can sensitize cancer cells to TNF-α- and TRAIL-induced apoptosis for their use in combination with TNF-α or TRAIL. It was previously reported that the bark extract of Thevetia peruviana showed a reversal effect on TRAIL-resistance in human gastric adenocarcinoma cell lines...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454460/melatonin-treatment-induces-apoptosis-through-regulating-the-nuclear-factor-%C3%AE%C2%BAb-and-mitogen-activated-protein-kinase-signaling-pathways-in-human-gastric-cancer-sgc7901-cells
#8
Weimin Li, Zhonglue Wang, Yina Chen, Kaijing Wang, Ting Lu, Fei Ying, Mengdi Fan, Zhiyin Li, Jiansheng Wu
Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen-activated protein kinase signaling pathway, involving p38 and c-Jun-N-terminal kinase (JNK), were investigated in SGC7901 gastric cancer cells. In addition, the effect of melatonin on the survival, migration and apoptosis of these cells was investigated in vitro in order to evaluate the use of melatonin for the treatment of gastric cancer...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454448/gnaq-mutation-r183q-as-a-potential-cause-of-familial-sturge-weber-syndrome-a-case-report
#9
Zhengyi Huang, Yuchi Li, Zengxia Zhao, Jun Hu, Xiaoxin Tong, Xuhui Chen, Shuyun Liu, Xiaonan Xu, Yongjun Tao, Tingting Wang, Xin Cheng, Yangyang Dai, Yaoting Gui, Jun Wu
Sturge-Weber syndrome (SWS) is a rare neurocutaneous disorder whose etiology remains unclear. To investigate the genetic contribution underlying this disease, the genetic variants of a 4-generation family with a history of SWS was analyzed in the present study. SWS was diagnosed in 3 of the family members (II-1, III-11 and IV-6). Sanger sequencing was performed to identify mutations in G protein subunit αq (GNAQ) and RAS p21 protein activator 1 exons in the 3 patients with SWS and other unaffected family members...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454445/role-of-reactive-oxygen-species-in-the-anticancer-activity-of-botanicals-comparing-sensitivity-profiles
#10
Zoya Cohen, Yair Maimon, Noah Samuels, Raanan Berger
Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer-herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS-inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS-independent botanicals that displayed divergent botanical-specific profiles...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454442/identification-of-target-genes-of-cediranib-in-alveolar-soft-part-sarcoma-using-a-gene-microarray
#11
Wenhua Jiang, Pengfei Liu, Xiaodong Li, Ping Wang
The aim of the present study was to identify the target genes of cediranib and the associated signaling pathways in alveolar soft part sarcoma (ASPS). A microarray dataset (GSE32569) was obtained from the Gene Expression Omnibus database. The R software package was used for data normalization and screening of differentially expressed genes (DEGs). The Database for Annotation, Visualization and Integrated Discovery was used to perform Gene Ontology analysis. Gene Set Enrichment Analysis was performed to obtain the up- and downregulated pathways in ASPS...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454441/microrna-130b-promotes-cell-migration-and-invasion-by-inhibiting-peroxisome-proliferator-activated-receptor-%C3%AE-in-human-glioma
#12
Peidong Li, Xinjun Wang, Qiao Shan, Yuehui Wu, Zhen Wang
Glioma is the most common and aggressive type of primary brain tumor. MicroRNA (miR)-130b functions as a tumor-associated miR. The dysregulation of miR-130b is involved in numerous biological characteristics and properties of certain types of cancer. The present study revealed the function and possible molecular mechanism of miR-130b in glioma cells, reporting that the level of miR-130b was markedly higher, increasing progressively as the histologic grade of the glioma increased, compared with the level in normal tissues...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454440/ffj-3-inhibits-pkm2-protein-expression-via-the-pi3k-akt-signaling-pathway-and-activates-the-mitochondrial-apoptosis-signaling-pathway-in-human-cancer-cells
#13
Dengyun Li, Xiaoli Wei, Mingming Ma, Huina Jia, Yu Zhang, Wenyi Kang, Tianxiao Wang, Xiaoyan Shi
Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madder) was used in order to determine the anticancer activity of the compound and investigate the potential mechanisms underlying this effect in human cancer cells. The results of the present study revealed that FFJ-3 inhibited the survival of HepG2 human hepatoma cells, MCF-7 human breast cancer cells and A549 human lung adenocarcinoma cells using the MTT assay...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454439/oct4-induces-emt-through-lef1-%C3%AE-catenin-dependent-wnt-signaling-pathway-in-hepatocellular-carcinoma
#14
Lu Sun, Tianhua Liu, Shu Zhang, Kun Guo, Yinkun Liu
Octamer 4 (Oct4), a member of the Pit-Oct-Unc transcription factor family required to maintain self-renewal and pluripotency of embryonic stem cells, has been previously identified to be associated with tumorigenesis and malignant transformation of numerous types of cancer including hepatocellular carcinoma (HCC). The present data shows that Oct4 enhances cancer stem cell properties and increases invasion ability in the Huh7 cell line. To increase understanding of the role of Oct4 in HCC, the present study used a functional genomics approach and analyzed the resulting transcriptional profiles to identify Oct4-dependent genes in Huh7...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454438/chk2-is-involved-in-the-p53-independent-radiosensitizing-effects-of-valproic-acid
#15
Dong Wan Choo, Sung Ho Goh, Young Woo Cho, Hye Jung Baek, Eun Jung Park, Noboru Motoyama, Tae Hyun Kim, Joo Young Kim, Sang Soo Kim
Radiotherapy is an effective treatment for the majority of types of localized solid cancer. However, the risk of side effects to the surrounding normal tissues limits radiotherapeutic approaches. Whilst the mechanism of action of valproic acid, an inhibitor of histone deacetylase, remains unknown, the inhibitor is a potential antineoplastic radiosensitizer. The present study demonstrated the in vitro radiosensitizing effects of valproic acid on the human breast cancer MCF7 cell line, and revealed that valproic acid increased the level of DNA breakage, apoptosis and senescence...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454435/15-deoxy-%C3%AE-12-14-prostaglandin-j2-inhibits-migration-of-human-thyroid-carcinoma-cells-by-disrupting-focal-adhesion-complex-and-adherens-junction
#16
Ya-Chieh Wu, Yun-Ting Jhao, Yu-Chen Cheng, Ying Chen
Metastasis is frequently observed in human follicular thyroid carcinoma. The present study investigated the peroxisome proliferator-activated receptor γ agonist, 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ2), and its effect on the migration of CGTH W-2 human thyroid carcinoma cells. 15d-PGJ2 decreased the survival rate of CGTH W-2 cells in a dose-dependent manner. The Transwell migration assay demonstrated that 15d-PGJ2 reduced the migration rate of CGTH W-2 cells by 35% following treatment with 30 µM 15d-PGJ2 compared with control cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454433/deregulation-of-mir-193b-affects-the-growth-of-colon-cancer-cells-via-transforming-growth-factor-%C3%AE-and-regulation-of-the-smad3-pathway
#17
Kaiming Wu, Zhenxian Zhao, Jun Ma, Jianhui Chen, Jianjun Peng, Shibin Yang, Yulong He
MicroRNA-193b (miRNA-193b) is often differentially expressed and is an important regulator of gene expression in colon cancer. The aim of the present study was to determine whether miRNA-193b affects cell growth in colon cancer and to investigate the potential underlying mechanisms. Patients with colorectal cancer (CRC; n=20) and healthy volunteers (n=10) were enrolled from the Department of Gastrointestinal Surgery Center, First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, China). Western blot analysis was used to evaluate the protein expression of SMAD3 and transforming growth factor-β (TGF-β) in the patient samples...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454429/polyphenolic-compounds-from-korean-lonicera-japonica-thunb-induces-apoptosis-via-akt-and-caspase-cascade-activation-in-a549-cells
#18
Kwang Il Park, Hyeonsoo Park, Arulkumar Nagappan, Gyeong Eun Hong, Silvia Yumnam, Ho Jeong Lee, Eun Hee Kim, Won Sup Lee, Sung Chul Shin, Jin A Kim, Sang Joon Lee, Jin Yeul Ma, Taesun Min, Jeong Doo Heo, Gon Sup Kim
Lonicera japonica Thunb. (L. japonica T.) has historically been used in Korean herbal medicine due to its anticancer and protective effects on the respiratory system. In the present study, the polyphenolic compounds in L. japonica T. were investigated using high-performance liquid chromatography coupled with tandem mass spectrometry, and its anticancer effects on A549 non-small-cell lung cancer cells were studied. Polyphenolic compounds potentially inhibit A549 cells in a dose-dependent manner. Flow cytometry and western blot analysis demonstrated that polyphenolic compounds induce apoptosis by regulating the protein expression levels of caspases, poly-(ADP-ribose) polymerase and the B-cell lymphoma-2-associated X-protein/B-cell lymphoma-extra large ratio...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454424/association-between-polymorphisms-in-tp53-and-mdm2-genes-and-susceptibility-to-prostate-cancer
#19
Mohammad Hashemi, Shadi Amininia, Mahboubeh Ebrahimi, Nasser Simforoosh, Abbas Basiri, Seyed Amir Mohsen Ziaee, Behzad Narouie, Mehdi Sotoudeh, Mohammad Javad Mollakouchekian, Esmaeil Rezghi Maleki, Hamideh Hanafi-Bojd, Maryam Rezaei, Gholamreza Bahari, Mohsen Taheri, Saeid Ghavami
Tumor protein 53 (TP53), a tumor suppressor gene, is a vital cellular cancer suppressor in multicellular organisms. Murine double minute-2 (MDM2) is an oncoprotein that inhibits TP53 activity. A number of studies have examined the association of TP53 and MDM2 polymorphisms with the risk of common forms of cancer, but the findings remain inconclusive. The present study aimed to evaluate the impact of the 40-bp insertion/deletion (I/D) polymorphism (rs3730485) in the MDM2 promoter region and the 16-bp I/D polymorphism (rs17878362) in TP53 on the susceptibility of prostate cancer (PCa) in a sample of the Iranian population...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454421/notch-is-a-critical-regulator-in-cervical-cancer-by-regulating-numb-splicing
#20
Cai Rong, Yu Feng, Zhou Ye
Cervical cancer, which is the second most common female malignancy, is characterized by the consistent presence of human papillomavirus. Inappropriate activation of Notch signaling has been associated with various types of cancer; however, the role of Notch in cervical cancer remains unclear. The present study aimed to investigate the role of Notch in cervical cancer. The methods used included the generation of plasmids, viability assays, polymerase chain reaction and western blotting The present findings demonstrated that cervical cancer samples also consistently exhibit abnormal activation of the Notch pathway...
April 2017: Oncology Letters
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