Leon French, Courtney Gray, Gabriel Leonard, Michel Perron, G Bruce Pike, Louis Richer, Jean R Séguin, Suzanne Veillette, C John Evans, Eric Artiges, Tobias Banaschewski, Arun W L Bokde, Uli Bromberg, Ruediger Bruehl, Christian Buchel, Anna Cattrell, Patricia J Conrod, Herta Flor, Vincent Frouin, Jurgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Herve Lemaitre, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Melissa Marie Pangelinan, Luise Poustka, Marcella Rietschel, Michael N Smolka, Henrik Walter, Robert Whelan, Nic J Timpson, Gunter Schumann, George Davey Smith, Zdenka Pausova, Tomáš Paus
IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England...
October 2015: JAMA Psychiatry