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Austin T Baldwin, Amy M Clemons, Bryan T Phillips
The Wnt/β-catenin signaling pathway is utilized across metazoans. However, the mechanism of signal transduction, especially dissociation of the β-catenin destruction complex by Dishevelled proteins, remains controversial. Here, we describe the function of the Dishevelled paralogs DSH-2 and MIG-5 in the Wnt/β-catenin asymmetry (WβA) pathway in Caenorhabditis elegans, where WβA drives asymmetric cell divisions throughout development. We find that DSH-2 and MIG-5 redundantly regulate cell fate in hypodermal seam cells...
March 1, 2016: Journal of Cell Science
Amanda L Zacharias, Travis Walton, Elicia Preston, John Isaac Murray
The Wnt signaling pathway plays a conserved role during animal development in transcriptional regulation of distinct targets in different developmental contexts but it remains unclear whether quantitative differences in the nuclear localization of effector proteins TCF and β-catenin contribute to context-specific regulation. We investigated this question in Caenorhabditis elegans embryos by quantifying nuclear localization of fluorescently tagged SYS-1/β-catenin and POP-1/TCF and expression of Wnt ligands at cellular resolution by time-lapse microscopy and automated lineage tracing...
October 2015: PLoS Genetics
Seung Bum Han, Joon Chul Kim, Dong Hwan Lee, Hyo Sin Kim, Jun Sung Koh, Won Sok Hur, Kang Jun Cho
PURPOSE: This study aimed to investigate the effects of preoperative Valsalva leak point pressure (VLPP) on the outcomes of the single-incision midurethral sling procedure (Needleless® System) in female stress urinary incon­tinence (SUI). MATERIALS AND METHODS: We evaluated 112 patients who underwent midurethral sling placement for SUI using the Needleless® System. Patients were divided into two groups according to their preoperative VLPP values: VLPP >90 cmH2O (group 1) and VLPP 60-90 cmH2O (group 2)...
July 2015: Urology Journal
Leon French, Courtney Gray, Gabriel Leonard, Michel Perron, G Bruce Pike, Louis Richer, Jean R Séguin, Suzanne Veillette, C John Evans, Eric Artiges, Tobias Banaschewski, Arun W L Bokde, Uli Bromberg, Ruediger Bruehl, Christian Buchel, Anna Cattrell, Patricia J Conrod, Herta Flor, Vincent Frouin, Jurgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Herve Lemaitre, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Melissa Marie Pangelinan, Luise Poustka, Marcella Rietschel, Michael N Smolka, Henrik Walter, Robert Whelan, Nic J Timpson, Gunter Schumann, George Davey Smith, Zdenka Pausova, Tomáš Paus
IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England...
October 2015: JAMA Psychiatry
Manol Lazarov, Thomas De Bo, Bart Poffyn, Gwen Sys
OBJECTIVE: In pursuance of thoroughly understanding and facilitating the evaluation of the radiological changes in the preloaded bone by Compliant Pre-Stress osseointegration (Compress Biomet, Warsaw, Indiana) a new staging method was created depicting four stages. METHODS: Two cohorts (10 and 17 patients resp., not-receiving and receiving chemotherapy) were compared in terms of progression of osseointegration. Based on the changes at the bone-metal interface seen on röntgenorgrams four stages were defined: stage 0: immediate postoperative status, no ingrowth, or noncalcified callus; stage 1: early mineralization, calcified callus; stage 2: mature mineralization; and stage 3: hypertrophy at the level of the pins...
2015: BioMed Research International
Jean Shin, Celine Bourdon, Manon Bernard, Michael D Wilson, Eva Reischl, Melanie Waldenberger, Barbara Ruggeri, Gunter Schumann, Sylvane Desrivieres, Alexander Leemans, Michal Abrahamowicz, Gabriel Leonard, Louis Richer, Luigi Bouchard, Daniel Gaudet, Tomas Paus, Zdenka Pausova
DNA methylation may contribute to the etiology of complex genetic disorders through its impact on genome integrity and gene expression; it is modulated by DNA-sequence variants, named methylation quantitative trait loci (meQTLs). Most meQTLs influence methylation of a few CpG dinucleotides within short genomic regions (<3 kb). Here, we identified a layered genetic control of DNA methylation at numerous CpGs across a long 300 kb genomic region. This control involved a single long-range meQTL and multiple local meQTLs...
October 15, 2015: Human Molecular Genetics
Louise Skov, Sys Stybe Johansen, Kristian Linnet
Brain tissue is a useful alternative to blood in postmortem forensic investigations, but scarcity of information on reference concentrations in brain tissue makes interpretation challenging. Here we present a study of 43 cases where the antipsychotic drug quetiapine was quantified in brain tissue and related to concentrations in postmortem blood. For cases, where quetiapine was unrelated to the cause of death (N = 36), the 10-90 percentiles for quetiapine concentrations in brain tissue were 0.030-1.54 mg/kg (median 0...
September 2015: Journal of Analytical Toxicology
A E Bautin, A S Iakovlev, D M Tashkhanov, S V Datsenko, A O Marichev, M A Popov, P A Fedotov
PURPOSE: To determine the specifics of inhaled iloprost effect on pulmonary and systemic hemodynamics in patients with pulmonary hypertension (PH) associated with left ventricular systolic dysfunction. MATERIALS AND METHODS: 47 vasore- activity tests (VRT) with 20 micrograms inhaled iloprost (Ventavis, Bayer) were performed in 39 candidates on heart transplantation. All patients had heart failure III-IV NYHA and PH with pulmonary vascular resistance (PVR) more than 2...
March 2015: Anesteziologiia i Reanimatologiia
Roger Y Chung, Dicken Chan, Jean Woo, Timothy Kwok, Jason C S Leung, Francisco T T Lai, Samuel Y S Wong
INTRODUCTION: Erectile dysfunction (ED) is commonly shown to be associated with subsequent cardiovascular mortality, but not respiratory mortality, despite respiratory disease being highly prevalent among ED patients. AIM: We aim to examine associations of ED with all-cause and cause-specific (i.e., cardiovascular and respiratory) mortality in a prospective cohort of 1,436 Chinese men, followed up from 2001 for a median of 11.5 years. METHODS: ED measurement was based on a single question of four categories at the 4-year follow up...
July 2015: Journal of Sexual Medicine
N Prera, M Zorob, J Heinz, I Uhlig, W Maier
BACKGROUND: The parapharyngeal space (PPR) is poorly accessible to clinical investigation due to its complex anatomy. Neoplasms in this area are rare, become lately symptomatic and are diagnosed in advanced stages. Multiple entities can be differentiated though malignant mesenchymal tumors are uncommon. PATIENTS: We describe characteristic course of spindle cell soft tissue tumors in PPR based on 5 patients: 2 cases of synovial sarkoma (SyS), 2 cases of malignant peripheral nerve sheath tumor (MPNST) without neurofibromatosis, 1 case of Ektomesenchymoma (EM)...
May 2015: Laryngo- Rhino- Otologie
Yuping Zhou, Liju Tan, Qiuting Pang, Feng Li, Jiangtao Wang
The influence of nutrients on the growth of Ulva prolifera was studied in the SYS by field experiments. The wet weight of U. prolifera gradiently increased from 11.94% to 25.92% in proportion to contents of DIN supply, which indicated DIN content was essentially decisive for the output of U. prolifera blooms. Continuous nutrient supply could promote the growth of U. prolifera, indicated by the increase of growth rate from 10.46% of the batch culture to 42.17% of the in situ culture. The higher P utilized rate in all treatments showed P was the potential limited factor for the growth of U...
June 15, 2015: Marine Pollution Bulletin
Hui Pan, Yu Zhao, Jia Li, Qian Wen, Ning Li
OBJECTIVE: To determine the recognition of healthy medical students on deqi after acupuncture, reveal the qualitative and quantitative rules of deqi and understand whether these rules are the factors of the clinical application of acupuncture therapy. METHODS: The class questionnaires were used for the investigation study on the understanding of deqi after acupuncture at Hegu (LI 4) or Zusanli (ST 36) in 86 healthy students in the clinical medicine class. RESULTS: (1) Deqi was a kind of complicated compound feelings, with many sensation qualities such as distending pain, distension and pain...
January 2015: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Geir Egil Eide, Lars Thomassen, Halvor Naess, Ulrike Waje-Andreassen
BACKGROUND: Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences. METHODS: From September 2010 to February 2014, all ischemic stroke patients aged 15-60 years were prospectively included in the Norwegian Stroke in the Young Study (NOR-SYS)...
March 12, 2015: BMC Neurology
Hee-Jung Choi, Timothy Loveless, Allison M Lynch, Injin Bang, Jeff Hardin, William I Weis
In metazoan adherens junctions, β-catenin links the cytoplasmic tail of classical cadherins to the F-actin-binding protein α-catenin. Phosphorylation of a Ser/Thr-rich region in the cadherin tail dramatically enhances affinity for β-catenin and promotes cell-cell adhesion in cell culture systems, but its importance has not been demonstrated in vivo. Here, we identify a critical phosphorylated serine in the C. elegans cadherin HMR-1 required for strong binding to the β-catenin homolog HMP-2. Ablation of this phosphoserine interaction produces developmental defects that resemble full loss-of-function (Hammerhead and Humpback) phenotypes...
April 6, 2015: Developmental Cell
Setu Vora, Bryan T Phillips
Caenorhabditis elegans embryos rapidly diversify cell fate using a modified Wnt/β-catenin signaling strategy to carry out serial asymmetric cell divisions (ACDs). Wnt-dependent ACDs rely on nuclear asymmetry of the transcriptional coactivator SYS-1/β-catenin between daughter cells to differentially activate Wnt-responsive target genes. Here, we investigate how dynamic localization of SYS-1 to mitotic centrosomes influences SYS-1 inheritance in daughter cells and cell-fate outcomes after ACD. Through yeast two-hybrid screening, we identify the centrosomal protein RSA-2 as a SYS-1 binding partner and show that localization of SYS-1 to mitotic centrosomes is dependent on RSA-2...
April 20, 2015: Current Biology: CB
Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Geir Egil Eide, Lars Thomassen, Halvor Naess, Ulrike Waje-Andreassen
BACKGROUND: Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences. METHODS: From September 2010 to February 2014, all ischemic stroke patients aged 15-60 years were prospectively included in the Norwegian Stroke in the Young Study (NOR-SYS)...
December 2015: BMC Neurology
Yunsuk Jeon, Pia Lahtinen, Riitta Meretoja, Helena Leino-Kilpi
OBJECTIVES: The purpose of this review was to analyse post-registration anaesthesia nursing education in the Nordic countries. The analysis was based on key determinants fundamental to analysing nursing education: 1) the sys]tem of anaesthesia nursing education, 2) entry requirements, 3) credits, the duration and the title or degree awarded, and 4) the amount of practical training. METHODS: A scoping review was approached in a systematic manner. The literature was analysed using deductive content analysis...
May 2015: Nurse Education Today
N Ryken, M Vanmaercke, J Wanyama, M Isabirye, S Vanonckelen, J Deckers, J Poesen
During the past decades, land use change in the Lake Victoria basin has significantly increased the sediment fluxes to the lake. These sediments as well as their associated nutrients and pollutants affect the food and water security of millions of people in one of Africa's most densely populated regions. Adequate catchment management strategies, based on a thorough understanding of the factors controlling runoff and sediment discharge are therefore crucial. Nonetheless, studies on the magnitude and dynamics of runoff and sediment discharge are very scarce for the Lake Victoria basin and the African Rift region...
April 1, 2015: Science of the Total Environment
Derrek P Hibar, Jason L Stein, Miguel E Renteria, Alejandro Arias-Vasquez, Sylvane Desrivières, Neda Jahanshad, Roberto Toro, Katharina Wittfeld, Lucija Abramovic, Micael Andersson, Benjamin S Aribisala, Nicola J Armstrong, Manon Bernard, Marc M Bohlken, Marco P Boks, Janita Bralten, Andrew A Brown, M Mallar Chakravarty, Qiang Chen, Christopher R K Ching, Gabriel Cuellar-Partida, Anouk den Braber, Sudheer Giddaluru, Aaron L Goldman, Oliver Grimm, Tulio Guadalupe, Johanna Hass, Girma Woldehawariat, Avram J Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H Lee, Loes M Olde Loohuis, Michelle Luciano, Christine Macare, Karen A Mather, Manuel Mattheisen, Yuri Milaneschi, Kwangsik Nho, Martina Papmeyer, Adaikalavan Ramasamy, Shannon L Risacher, Roberto Roiz-Santiañez, Emma J Rose, Alireza Salami, Philipp G Sämann, Lianne Schmaal, Andrew J Schork, Jean Shin, Lachlan T Strike, Alexander Teumer, Marjolein M J van Donkelaar, Kristel R van Eijk, Raymond K Walters, Lars T Westlye, Christopher D Whelan, Anderson M Winkler, Marcel P Zwiers, Saud Alhusaini, Lavinia Athanasiu, Stefan Ehrlich, Marina M H Hakobjan, Cecilie B Hartberg, Unn K Haukvik, Angelien J G A M Heister, David Hoehn, Dalia Kasperaviciute, David C M Liewald, Lorna M Lopez, Remco R R Makkinje, Mar Matarin, Marlies A M Naber, D Reese McKay, Margaret Needham, Allison C Nugent, Benno Pütz, Natalie A Royle, Li Shen, Emma Sprooten, Daniah Trabzuni, Saskia S L van der Marel, Kimm J E van Hulzen, Esther Walton, Christiane Wolf, Laura Almasy, David Ames, Sampath Arepalli, Amelia A Assareh, Mark E Bastin, Henry Brodaty, Kazima B Bulayeva, Melanie A Carless, Sven Cichon, Aiden Corvin, Joanne E Curran, Michael Czisch, Greig I de Zubicaray, Allissa Dillman, Ravi Duggirala, Thomas D Dyer, Susanne Erk, Iryna O Fedko, Luigi Ferrucci, Tatiana M Foroud, Peter T Fox, Masaki Fukunaga, J Raphael Gibbs, Harald H H Göring, Robert C Green, Sebastian Guelfi, Narelle K Hansell, Catharina A Hartman, Katrin Hegenscheid, Andreas Heinz, Dena G Hernandez, Dirk J Heslenfeld, Pieter J Hoekstra, Florian Holsboer, Georg Homuth, Jouke-Jan Hottenga, Masashi Ikeda, Clifford R Jack, Mark Jenkinson, Robert Johnson, Ryota Kanai, Maria Keil, Jack W Kent, Peter Kochunov, John B Kwok, Stephen M Lawrie, Xinmin Liu, Dan L Longo, Katie L McMahon, Eva Meisenzahl, Ingrid Melle, Sebastian Mohnke, Grant W Montgomery, Jeanette C Mostert, Thomas W Mühleisen, Michael A Nalls, Thomas E Nichols, Lars G Nilsson, Markus M Nöthen, Kazutaka Ohi, Rene L Olvera, Rocio Perez-Iglesias, G Bruce Pike, Steven G Potkin, Ivar Reinvang, Simone Reppermund, Marcella Rietschel, Nina Romanczuk-Seiferth, Glenn D Rosen, Dan Rujescu, Knut Schnell, Peter R Schofield, Colin Smith, Vidar M Steen, Jessika E Sussmann, Anbupalam Thalamuthu, Arthur W Toga, Bryan J Traynor, Juan Troncoso, Jessica A Turner, Maria C Valdés Hernández, Dennis van 't Ent, Marcel van der Brug, Nic J A van der Wee, Marie-Jose van Tol, Dick J Veltman, Thomas H Wassink, Eric Westman, Ronald H Zielke, Alan B Zonderman, David G Ashbrook, Reinmar Hager, Lu Lu, Francis J McMahon, Derek W Morris, Robert W Williams, Han G Brunner, Randy L Buckner, Jan K Buitelaar, Wiepke Cahn, Vince D Calhoun, Gianpiero L Cavalleri, Benedicto Crespo-Facorro, Anders M Dale, Gareth E Davies, Norman Delanty, Chantal Depondt, Srdjan Djurovic, Wayne C Drevets, Thomas Espeseth, Randy L Gollub, Beng-Choon Ho, Wolfgang Hoffmann, Norbert Hosten, René S Kahn, Stephanie Le Hellard, Andreas Meyer-Lindenberg, Bertram Müller-Myhsok, Matthias Nauck, Lars Nyberg, Massimo Pandolfo, Brenda W J H Penninx, Joshua L Roffman, Sanjay M Sisodiya, Jordan W Smoller, Hans van Bokhoven, Neeltje E M van Haren, Henry Völzke, Henrik Walter, Michael W Weiner, Wei Wen, Tonya White, Ingrid Agartz, Ole A Andreassen, John Blangero, Dorret I Boomsma, Rachel M Brouwer, Dara M Cannon, Mark R Cookson, Eco J C de Geus, Ian J Deary, Gary Donohoe, Guillén Fernández, Simon E Fisher, Clyde Francks, David C Glahn, Hans J Grabe, Oliver Gruber, John Hardy, Ryota Hashimoto, Hilleke E Hulshoff Pol, Erik G Jönsson, Iwona Kloszewska, Simon Lovestone, Venkata S Mattay, Patrizia Mecocci, Colm McDonald, Andrew M McIntosh, Roel A Ophoff, Tomas Paus, Zdenka Pausova, Mina Ryten, Perminder S Sachdev, Andrew J Saykin, Andy Simmons, Andrew Singleton, Hilkka Soininen, Joanna M Wardlaw, Michael E Weale, Daniel R Weinberger, Hieab H H Adams, Lenore J Launer, Stephan Seiler, Reinhold Schmidt, Ganesh Chauhan, Claudia L Satizabal, James T Becker, Lisa Yanek, Sven J van der Lee, Maritza Ebling, Bruce Fischl, W T Longstreth, Douglas Greve, Helena Schmidt, Paul Nyquist, Louis N Vinke, Cornelia M van Duijn, Luting Xue, Bernard Mazoyer, Joshua C Bis, Vilmundur Gudnason, Sudha Seshadri, M Arfan Ikram, Nicholas G Martin, Margaret J Wright, Gunter Schumann, Barbara Franke, Paul M Thompson, Sarah E Medland
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts...
April 9, 2015: Nature
N Van Der Vekens, A Decloedt, S Sys, S Ven, D De Clercq, G van Loon
Cardiac troponin I (cTnI) is a marker for detection of myocardial damage in horses. Many cTnI assays exist and medical studies have shown that the clinical performance of assays differs. The aim of this study was to compare two different cTnI assays in horses. Serum samples were taken from 23 healthy horses (group 1) and 72 horses with cardiac disease (group 2). Cardiac troponin I was determined using assay 1 in laboratory A (limit of detection, LOD, 0.03 ng/mL) and assay 2 in laboratories B and C (LOD 0...
January 2015: Veterinary Journal
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