keyword
https://read.qxmd.com/read/37503055/sys-1-beta-catenin-inheritance-and-regulation-by-wnt-signaling-during-asymmetric-cell-division
#1
Maria F Valdes Michel, Bryan T Phillips
Asymmetric cell division (ACD) allows daughter cells of a polarized mother to acquire different developmental fates. In C. elegans , the Wnt/β-catenin Asymmetry (WβA) pathway oversees many embryonic and larval ACDs; here, a Wnt gradient induces an asymmetric distribution of Wnt signaling components within the dividing mother cell. One terminal nuclear effector of the WβA pathway is the transcriptional activator SYS-1/β-catenin. SYS-1 is sequentially negatively regulated during ACD; first by centrosomal regulation and subsequent proteasomal degradation and second by asymmetric activity of the β-catenin "destruction complex" in one of the two daughter cells, which decreases SYS-1 levels in the absence of WβA signaling...
July 21, 2023: bioRxiv
https://read.qxmd.com/read/35660370/pop-1-tcf-ref-2-zic-and-t-box-factors-regulate-the-development-of-anterior-cells-in-the-c-elegans-embryo
#2
JOURNAL ARTICLE
Jonathan D Rumley, Elicia A Preston, Dylan Cook, Felicia L Peng, Amanda L Zacharias, Lucy Wu, Ilona Jileaeva, John Isaac Murray
Patterning of the anterior-posterior axis is fundamental to animal development. The Wnt pathway plays a major role in this process by activating the expression of posterior genes in animals from worms to humans. This observation raises the question of whether the Wnt pathway or other regulators control the expression of the many anterior-expressed genes. We found that the expression of five anterior-specific genes in Caenorhabditis elegans embryos depends on the Wnt pathway effectors pop-1/TCF and sys-1/β-catenin...
September 2022: Developmental Biology
https://read.qxmd.com/read/33455886/hepatic-vein-flow-index-during-orthotopic-liver-transplantation-as-a-predictive-factor-for-postoperative-early-allograft-dysfunction
#3
JOURNAL ARTICLE
Yoshihisa Morita, Taro Kariya, Shunji Nagai, Ahmad Itani, Michael Isley, Kenichi Tanaka
OBJECTIVES: The authors devised a hepatic vein flow index (HVFi), using intraoperative transesophageal echocardiography and graft weight, and investigated its predictive value for postoperative graft function in orthotopic liver transplant. DESIGN: Prospective clinical trial. SETTING,: Single-center tertiary academic hospital. PARTICIPANTS: Ninety-seven patients who had orthotopic liver transplant with the piggy-back technique between February 2018 and December 2019...
November 2021: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/32945981/disease-course-and-obstetric-outcomes-of-pregnancies-in-juvenile-idiopathic-arthritis-are-there-any-differences-among-disease-subtypes-a-single-centre-retrospective-study-of-prospectively-followed-pregnancies-in-a-dedicated-pregnancy-clinic
#4
JOURNAL ARTICLE
Antía García-Fernández, Maria Chiara Gerardi, Francesca Crisafulli, Matteo Filippini, Micaela Fredi, Roberto Gorla, Maria Grazia Lazzaroni, Andrea Lojacono, Cecilia Nalli, Francesca Ramazzotto, Marco Taglietti, Cristina Zanardini, Sonia Zatti, Franco Franceschini, Angela Tincani, Laura Andreoli
To study disease activity during pregnancy and obstetric outcomes in patients with juvenile idiopathic arthritis (JIA) upon different subsets and with focus on medication use. Retrospective observational study of 22 pregnancies in 16 JIA patients (95.5% Caucasian) who were followed between 2010 and 2018. Disease activity, flares and medications were recorded before conception, during each trimester and postpartum period. Pregnancies occurred in 10 (45.5%) oligoarticular extended (OLA-E), 6 (27.3%) in polyarticular (PLA), 4 in (18...
January 2021: Clinical Rheumatology
https://read.qxmd.com/read/32550426/lrp-2-controls-the-localization-of-c-elegans-sys-1-beta-catenin
#5
JOURNAL ARTICLE
Paul Minor, Paul Sternberg
No abstract text is available yet for this article.
August 27, 2019: microPublication. Biology
https://read.qxmd.com/read/29962933/wnts-promote-synaptic-assembly-through-t-cell-specific-transcription-factors-in-caenorhabditis-elegans
#6
JOURNAL ARTICLE
Yanjun Shi, Qian Li, Zhiyong Shao
Synapses are specialized neuronal connections essential for neuronal function. Defects in synaptic assembly or maintenance usually lead to various neurological disorders. Synaptic assembly is regulated by secreted molecules such as Wnts. Wnts are a large family of conserved glycosylated signaling molecules involved in many aspects of neural development and maintenance. However, the molecular mechanisms by which Wnts regulate synaptic assembly remain elusive due to the large number of ligands/receptors, the diversity of signaling cascades and the complexity of the nervous system...
2018: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/26795562/unique-and-redundant-%C3%AE-catenin-regulatory-roles-of-two-dishevelled-paralogs-during-c-elegans-asymmetric-cell-division
#7
JOURNAL ARTICLE
Austin T Baldwin, Amy M Clemons, Bryan T Phillips
The Wnt/β-catenin signaling pathway is utilized across metazoans. However, the mechanism of signal transduction, especially dissociation of the β-catenin destruction complex by Dishevelled proteins, remains controversial. Here, we describe the function of the Dishevelled paralogs DSH-2 and MIG-5 in the Wnt/β-catenin asymmetry (WβA) pathway in Caenorhabditis elegans, where WβA drives asymmetric cell divisions throughout development. We find that DSH-2 and MIG-5 redundantly regulate cell fate in hypodermal seam cells...
March 1, 2016: Journal of Cell Science
https://read.qxmd.com/read/26488501/quantitative-differences-in-nuclear-%C3%AE-catenin-and-tcf-pattern-embryonic-cells-in-c-elegans
#8
JOURNAL ARTICLE
Amanda L Zacharias, Travis Walton, Elicia Preston, John Isaac Murray
The Wnt signaling pathway plays a conserved role during animal development in transcriptional regulation of distinct targets in different developmental contexts but it remains unclear whether quantitative differences in the nuclear localization of effector proteins TCF and β-catenin contribute to context-specific regulation. We investigated this question in Caenorhabditis elegans embryos by quantifying nuclear localization of fluorescently tagged SYS-1/β-catenin and POP-1/TCF and expression of Wnt ligands at cellular resolution by time-lapse microscopy and automated lineage tracing...
October 2015: PLoS Genetics
https://read.qxmd.com/read/26341767/the-effect-of-valsalva-leak-point-pressure-on-outcomes-of-the-needleless-%C3%A2-system-in-female-stress-urinary-incontinence
#9
JOURNAL ARTICLE
Seung Bum Han, Joon Chul Kim, Dong Hwan Lee, Hyo Sin Kim, Jun Sung Koh, Won Sok Hur, Kang Jun Cho
PURPOSE: This study aimed to investigate the effects of preoperative Valsalva leak point pressure (VLPP) on the outcomes of the single-incision midurethral sling procedure (Needleless® System) in female stress urinary incon­tinence (SUI). MATERIALS AND METHODS: We evaluated 112 patients who underwent midurethral sling placement for SUI using the Needleless® System. Patients were divided into two groups according to their preoperative VLPP values: VLPP >90 cmH2O (group 1) and VLPP 60-90 cmH2O (group 2)...
July 2015: Urology Journal
https://read.qxmd.com/read/26308966/early-cannabis-use-polygenic-risk-score-for-schizophrenia-and-brain-maturation-in-adolescence
#10
JOURNAL ARTICLE
Leon French, Courtney Gray, Gabriel Leonard, Michel Perron, G Bruce Pike, Louis Richer, Jean R Séguin, Suzanne Veillette, C John Evans, Eric Artiges, Tobias Banaschewski, Arun W L Bokde, Uli Bromberg, Ruediger Bruehl, Christian Buchel, Anna Cattrell, Patricia J Conrod, Herta Flor, Vincent Frouin, Jurgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Herve Lemaitre, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Melissa Marie Pangelinan, Luise Poustka, Marcella Rietschel, Michael N Smolka, Henrik Walter, Robert Whelan, Nic J Timpson, Gunter Schumann, George Davey Smith, Zdenka Pausova, Tomáš Paus
IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England...
October 2015: JAMA Psychiatry
https://read.qxmd.com/read/26266259/radiologic-evaluation-of-compressive-osseointegration-for-the-fixation-of-reconstruction-prostheses-after-tumor-resection
#11
JOURNAL ARTICLE
Manol Lazarov, Thomas De Bo, Bart Poffyn, Gwen Sys
OBJECTIVE: In pursuance of thoroughly understanding and facilitating the evaluation of the radiological changes in the preloaded bone by Compliant Pre-Stress osseointegration (Compress Biomet, Warsaw, Indiana) a new staging method was created depicting four stages. METHODS: Two cohorts (10 and 17 patients resp., not-receiving and receiving chemotherapy) were compared in terms of progression of osseointegration. Based on the changes at the bone-metal interface seen on röntgenorgrams four stages were defined: stage 0: immediate postoperative status, no ingrowth, or noncalcified callus; stage 1: early mineralization, calcified callus; stage 2: mature mineralization; and stage 3: hypertrophy at the level of the pins...
2015: BioMed Research International
https://read.qxmd.com/read/26220975/layered-genetic-control-of-dna-methylation-and-gene-expression-a-locus-of-multiple-sclerosis-in-healthy-individuals
#12
JOURNAL ARTICLE
Jean Shin, Celine Bourdon, Manon Bernard, Michael D Wilson, Eva Reischl, Melanie Waldenberger, Barbara Ruggeri, Gunter Schumann, Sylvane Desrivieres, Alexander Leemans, Michal Abrahamowicz, Gabriel Leonard, Louis Richer, Luigi Bouchard, Daniel Gaudet, Tomas Paus, Zdenka Pausova
DNA methylation may contribute to the etiology of complex genetic disorders through its impact on genome integrity and gene expression; it is modulated by DNA-sequence variants, named methylation quantitative trait loci (meQTLs). Most meQTLs influence methylation of a few CpG dinucleotides within short genomic regions (<3 kb). Here, we identified a layered genetic control of DNA methylation at numerous CpGs across a long 300 kb genomic region. This control involved a single long-range meQTL and multiple local meQTLs...
October 15, 2015: Human Molecular Genetics
https://read.qxmd.com/read/26159868/postmortem-quetiapine-reference-concentrations-in-brain-and-blood
#13
JOURNAL ARTICLE
Louise Skov, Sys Stybe Johansen, Kristian Linnet
Brain tissue is a useful alternative to blood in postmortem forensic investigations, but scarcity of information on reference concentrations in brain tissue makes interpretation challenging. Here we present a study of 43 cases where the antipsychotic drug quetiapine was quantified in brain tissue and related to concentrations in postmortem blood. For cases, where quetiapine was unrelated to the cause of death (N = 36), the 10-90 percentiles for quetiapine concentrations in brain tissue were 0.030-1.54 mg/kg (median 0...
September 2015: Journal of Analytical Toxicology
https://read.qxmd.com/read/26148353/-specifics-of-inhaled-iloprost-pharmacodynamics-in-patients-with-severe-left-ventricular-systolic-dysfunction
#14
JOURNAL ARTICLE
A E Bautin, A S Iakovlev, D M Tashkhanov, S V Datsenko, A O Marichev, M A Popov, P A Fedotov
PURPOSE: To determine the specifics of inhaled iloprost effect on pulmonary and systemic hemodynamics in patients with pulmonary hypertension (PH) associated with left ventricular systolic dysfunction. MATERIALS AND METHODS: 47 vasore- activity tests (VRT) with 20 micrograms inhaled iloprost (Ventavis, Bayer) were performed in 39 candidates on heart transplantation. All patients had heart failure III-IV NYHA and PH with pulmonary vascular resistance (PVR) more than 2...
March 2015: Anesteziologiia i Reanimatologiia
https://read.qxmd.com/read/26104065/erectile-dysfunction-is-associated-with-subsequent-cardiovascular-and-respiratory-mortality-in-cohort-of-1-436-chinese-elderly-men
#15
JOURNAL ARTICLE
Roger Y Chung, Dicken Chan, Jean Woo, Timothy Kwok, Jason C S Leung, Francisco T T Lai, Samuel Y S Wong
INTRODUCTION: Erectile dysfunction (ED) is commonly shown to be associated with subsequent cardiovascular mortality, but not respiratory mortality, despite respiratory disease being highly prevalent among ED patients. AIM: We aim to examine associations of ED with all-cause and cause-specific (i.e., cardiovascular and respiratory) mortality in a prospective cohort of 1,436 Chinese men, followed up from 2001 for a median of 11.5 years. METHODS: ED measurement was based on a single question of four categories at the 4-year follow up...
July 2015: Journal of Sexual Medicine
https://read.qxmd.com/read/25951445/-spindlecell-soft-tissue-tumors-of-para-and-retropharyngeal-space-5-patients-review-of-literature
#16
REVIEW
N Prera, M Zorob, J Heinz, I Uhlig, W Maier
BACKGROUND: The parapharyngeal space (PPR) is poorly accessible to clinical investigation due to its complex anatomy. Neoplasms in this area are rare, become lately symptomatic and are diagnosed in advanced stages. Multiple entities can be differentiated though malignant mesenchymal tumors are uncommon. PATIENTS: We describe characteristic course of spindle cell soft tissue tumors in PPR based on 5 patients: 2 cases of synovial sarkoma (SyS), 2 cases of malignant peripheral nerve sheath tumor (MPNST) without neurofibromatosis, 1 case of Ektomesenchymoma (EM)...
May 2015: Laryngo- Rhino- Otologie
https://read.qxmd.com/read/25931173/influence-of-nutrients-pollution-on-the-growth-and-organic-matter-output-of-ulva-prolifera-in-the-southern-yellow-sea-china
#17
JOURNAL ARTICLE
Yuping Zhou, Liju Tan, Qiuting Pang, Feng Li, Jiangtao Wang
The influence of nutrients on the growth of Ulva prolifera was studied in the SYS by field experiments. The wet weight of U. prolifera gradiently increased from 11.94% to 25.92% in proportion to contents of DIN supply, which indicated DIN content was essentially decisive for the output of U. prolifera blooms. Continuous nutrient supply could promote the growth of U. prolifera, indicated by the increase of growth rate from 10.46% of the batch culture to 42.17% of the in situ culture. The higher P utilized rate in all treatments showed P was the potential limited factor for the growth of U...
June 15, 2015: Marine Pollution Bulletin
https://read.qxmd.com/read/25906574/-primary-discussion-of-qualitative-and-quantitative-recognition-on-deqi-after-acupuncture-a-study-report-of-west-china-school-of-medicine
#18
JOURNAL ARTICLE
Hui Pan, Yu Zhao, Jia Li, Qian Wen, Ning Li
OBJECTIVE: To determine the recognition of healthy medical students on deqi after acupuncture, reveal the qualitative and quantitative rules of deqi and understand whether these rules are the factors of the clinical application of acupuncture therapy. METHODS: The class questionnaires were used for the investigation study on the understanding of deqi after acupuncture at Hegu (LI 4) or Zusanli (ST 36) in 86 healthy students in the clinical medicine class. RESULTS: (1) Deqi was a kind of complicated compound feelings, with many sensation qualities such as distending pain, distension and pain...
January 2015: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/25884546/stroke-patients-knowledge-about-cardiovascular-family-history%C3%A2-%C3%A2-the-norwegian-stroke-in-the-young-study-nor-sys
#19
JOURNAL ARTICLE
Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Geir Egil Eide, Lars Thomassen, Halvor Naess, Ulrike Waje-Andreassen
BACKGROUND: Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences. METHODS: From September 2010 to February 2014, all ischemic stroke patients aged 15-60 years were prospectively included in the Norwegian Stroke in the Young Study (NOR-SYS)...
March 12, 2015: BMC Neurology
https://read.qxmd.com/read/25850673/a-conserved-phosphorylation-switch-controls-the-interaction-between-cadherin-and-%C3%AE-catenin-in-vitro-and-in-vivo
#20
JOURNAL ARTICLE
Hee-Jung Choi, Timothy Loveless, Allison M Lynch, Injin Bang, Jeff Hardin, William I Weis
In metazoan adherens junctions, β-catenin links the cytoplasmic tail of classical cadherins to the F-actin-binding protein α-catenin. Phosphorylation of a Ser/Thr-rich region in the cadherin tail dramatically enhances affinity for β-catenin and promotes cell-cell adhesion in cell culture systems, but its importance has not been demonstrated in vivo. Here, we identify a critical phosphorylated serine in the C. elegans cadherin HMR-1 required for strong binding to the β-catenin homolog HMP-2. Ablation of this phosphoserine interaction produces developmental defects that resemble full loss-of-function (Hammerhead and Humpback) phenotypes...
April 6, 2015: Developmental Cell
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