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https://www.readbyqxmd.com/read/29763719/small-cell-carcinoma-of-the-urinary-bladder-a-clinicopathologic-and-immunohistochemical-analysis-of-81-cases
#1
Gang Wang, Li Xiao, Miao Zhang, Ashish M Kamat, Arlene Siefker-Radtke, Colin P Dinney, Bogdan Czerniak, Charles C Guo
Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68years. Most bladder SmCC were presented at advanced stage with tumors invading the muscularis propria and beyond (n=77). SmCC was pure in 27 cases and mixed with other histologic types in 54 cases, including urothelial carcinoma (UC) (n=32), UC in situ (n=26), glandular (n=14), micropapillary (n=4), sarcomatoid (n=4), and squamous (n=3), and plasmacytoid (n=1) features...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29759053/histopathologic-and-immunohistochemistry-findings-in-feline-renal-cell-carcinoma
#2
Isao Matsumoto, James K Chambers, Kazumi Nibe, Ryohei Kinoshita, Ryohei Nishimura, Hiroyuki Nakayama, Kazuyuki Uchida
The biological behavior and immunohistochemical features of feline renal cell carcinoma (RCC) have not been well characterized. In the present study, immunohistochemical examinations were performed in 12 feline cases of RCC. The RCC consisted of solid ( n = 2), solid-tubular ( n = 2), tubular ( n = 3), papillary ( n = 2), tubulopapillary ( n = 2), and sarcomatoid ( n = 1) type lesions. Of the cases with RCC, 1 developed metastatic disease and 6 cases had no evidence of recurrence at 80 to 2292 days after surgery...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29748390/the-clinical-activity-of-pd-1-pd-l1-inhibitors-in-metastatic-non-clear-cell-renal-cell-carcinoma
#3
Rana R McKay, Dominick Bossé, Wanling Xie, Stephanie A M Wankowicz, Abdallah Flaifel, Raphael Brandao, Aly-Khan Lalani, Dylan J Martini, Xiao X Wei, David A Braun, Eliezer M Van Allen, Daniel Castellano, Guillermo de Velasco, J Connor Wells, Daniel Y C Heng, Andre P Fay, Fabio A Schutz, JoAnn Hsu, Sumanta Kumar Pal, Jae-Lyun Lee, James Hsieh, Lauren C Harshman, Sabina Signoretti, Robert J Motzer, Darren R Feldman, Toni K Choueiri
Programmed death 1 (PD-1) and PD ligand 1 (PD-L1) inhibitors have shown activity in metastatic clear cell renal cell carcinoma (ccRCC). Data on the activity of these agents in patients with non-clear cell RCC (nccRCC) or patients with sarcomatoid/rhabdoid differentiation is limited. In this multicenter analysis, we explored the efficacy of PD-1/PD-L1 inhibitors in patients with nccRCC or sarcomatoid/rhabdoid differentiation. Baseline and follow-up demographic, clinical, treatment, and radiographic data were collected...
May 10, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29731801/sarcomatoid-carcinoma-of-renal-pelvis-involving-ureter-and-renal-parenchyma-with-heterologous-osteosarcomatous-differentiation-a-case-report-and-review-of-literature
#4
Bhavya P Mohan, P L Jayalakshmy, V Letha, Suresh Bhat
Sarcomatoid carcinoma is a highgrade rare malignant tumor with both epithelial and mesenchymal components. Sarcomatoid carcinoma in the upper urinary tract is very rare. We reported here a case of sarcomatoid carcinoma of renal pelvis with osteosarcomatous differentiation, with involvement of the ureter and renal parenchyma in a 68-year-old female. Histologically, predominant pleomorphic spindle cell sarcoma component with osteoid production and urothelial carcinoma component with in situ areas were identified...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29715708/the-feasibility-of-thoracoscopic-left-pneumonectomy
#5
Hao Xu, Linyou Zhang
OBJECTIVE:  In this study, we describe our experience with video-assisted thoracoscopic surgery (VATS) left pneumonectomy as a treatment for advanced malignant and benign diseases. METHODS:  Patients who underwent VATS left pneumonectomy in our clinic between October 2013 and August 2017 were retrospectively evaluated. VATS pneumonectomy was successfully completed in 46 patients. We reviewed and analyzed the characteristics of the patients in addition to intraoperative parameters, chest tube duration, length of hospital stay, morbidity, and mortality...
May 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29713040/assessment-of-programmed-cell-death-ligand-1-expression-by-4-diagnostic-assays-and-its-clinicopathological-correlation-in-a-large-cohort-of-surgical-resected-non-small-cell-lung-carcinoma
#6
Anthony W H Chan, Joanna H M Tong, Johnny S H Kwan, Chit Chow, Lau Y Chung, Shuk L Chau, Raymond W M Lung, Calvin S H Ng, Innes Y P Wan, Tony S K Mok, Ka F To
Immune checkpoint blockade targeting the PD-1/PD-L1 axis has recently demonstrated efficacy and promise in cancer treatment. Appropriate biomarker selection is therefore essential for improving treatment efficacy. However, the establishment of PD-L1 assay in pathology laboratories is complicated by the presence of multiple testing platforms using different scoring systems. Here we assessed the PD-L1 expression in 713 consecutive non-small cell lung carcinomas by four commercially available PD-L1 immunohistochemical assays, namely, 22C3, 28-8, SP142 and SP263...
April 30, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29689242/swi-snf-protein-expression-status-in-fumarate-hydratase-deficient-renal-cell-carcinoma-immunohistochemical-analysis-of-32-tumors-from-28-patients
#7
Abbas Agaimy, Mahul B Amin, Anthony J Gill, Bernt Popp, André Reis, Daniel M Berney, Cristina Magi-Galluzzi, Mathilde Sibony, Steven C Smith, Saul Suster, Kiril Trpkov, Ondřej Hes, Arndt Hartmann
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare, aggressive RCC type, originally described in the setting of hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome which is defined by germline FH gene inactivation. Inactivation of components of the SWI/SNF chromatin remodelling complex is involved in renal medullary carcinoma (SMARCB1/INI1 loss), clear cell RCC (PBRM1 loss) and in subsets of dedifferentiated RCC of clear cell, chromophobe and papillary types (loss of different SWI/SNF components)...
April 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29689238/pseudomesotheliomatous-type-of-sarcomatoid-squamous-cell-lung-cancer-presenting-with-hemothorax
#8
Niravkumar K Sangani, Santosh Mathew Naliath
A 44 year old male presented with spontaneous massive hemothorax. Computed tomography (CT) scan revealed thickened and nodular pleura with no evidence of lung tumour. Patient underwent right open total pleurectomy. Histopathology and Immunohistochemistry studies of the pleura confirmed poorly differentiated sarcomatoid squamous cell carcinoma of lung with metastasis to pleura. The carcinoma was psuedomesothelimatous type due to its presentation as diffuse pleural thickening. This presentation of sarcomatoid cancer as pseudomesotheliomatous type with massive hemothorax is rare and can be considered as differential diagnosis in diffuse pleural thickening or hemothorax, especially in absence of clinically identifiable primary lung tumour...
April 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29684960/-two-cases-of-metastatic-and-recurrent-non-clear-cell-renal-cell-carcinoma-re-diagnosed-as-renal-mucinous-tubular-and-spindle-cell-carcinoma-during-long-term-follow-up
#9
Masashi Kubota, Toshinari Yamasaki, Yuki Teramoto, Katsuhiro Ito, Hideaki Takada, Toshihiro Magaribuchi, Atsuro Sawada, Shusuke Akamatsu, Hiromitsu Negoro, Ryoichi Saito, Takashi Kobayashi, Naoki Terada, Takahiro Inoue, Tomomi Kamba, Osamu Ogawa
Renal mucinous tubular and spindle cell carcinoma (MTSCC) is a rare, low-grade renal epithelial neoplasm. MTSCC has a lower malignant potential and shows relatively good prognosis, but can be difficult to distinguish from other renal cell carcinoma (RCC) subtypes. Here, we report two cases of metastatic and recurrent renal MTSCC diagnosed after long-term follow-up. Case 1 was a 79-year-old man with a history of macroscopic hematuria in whom a right kidney mass was detected and diagnosed as RCC (cT3bN0M0). After a radical nephrectomy, microscopic findings showed that the tumor consisted of spindle cells arranged in tubular patterns embedded in sarcomatoid tissues ; we diagnosed it as unclassified RCC with sarcomatoid differentiations (pT3aN0M0)...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684955/-a-case-of-sarcomatoid-squamous-cell-carcinoma-of-the-penis
#10
Atsushi Wanifuchi, Takashi Shimizu, Hiroshi Hotta
A 74-year-old man presented to our hospital with the swelling of penis in May 2016. Physical examination revealed a goose egg-sized lump at the tip of the penis under foreskin. After dorsal skin incision we confirmed the 7 cm tumor on the inner preputial skin and then resected the tumor with circumcision. Histopathological examination revealed sarcomatoid squamous cell carcinoma of the penis. Computed tomography (CT) revealed swelling of bilateral inguinal lymph nodes, and we performed partial penectomy with bilateral superficial inguinal lymph node dissection in July 2016...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29683821/urothelial-carcinoma-in-situ-of-the-bladder-with-glandular-differentiation-report-of-92-cases
#11
Zhiming Yang, Jonathan I Epstein
Urothelial carcinoma in situ (CIS) of the bladder with glandular differentiation (CIS-GL) is rare with some showing an association with small cell carcinoma. There is a paucity of data on whether CIS-GL diagnosed in the absence of invasive carcinoma is associated with an increased risk of developing small cell carcinoma of the bladder. Twenty-seven cases of CIS-GL were identified from the consult files of one of the authors from 2008 to 2015 without prior or coexisting invasive carcinoma at the time of diagnosis...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29681821/genomic-profiling-of-two-histologically-distinct-rare-urothelial-cancers-in-a-clinical-setting-to-identify-potential-therapeutic-options-for-treatment-and-management-of-disease
#12
Andrew N Hesse, William Fabricius, Christian A Thomas, Ramesh Gaindh, Robert Christman, Pavalan Selvam, Matthew Prego, Gregory Lewis, Jasmina Uvalic, Daniel Bergeron, Shelbi Burns, Bridgette Sisson, Kevin Kelly, Jens Rueter, Honey V Reddi
Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29669553/significant-response-to-nivolumab-for-metastatic-chromophobe-renal-cell-carcinoma-with-sarcomatoid-differentiation-a-case-report
#13
Go Noguchi, Sohgo Tsutsumi, Masato Yasui, Shinji Ohtake, Susumu Umemoto, Noboru Nakaigawa, Masahiro Yao, Takeshi Kishida
BACKGROUND: The treatment of advanced or metastatic renal cell carcinoma (RCC) has drastically changed since the approval of immune checkpoint therapy. Nivolumab is a treatment option for patients with metastatic RCC, previously treated with targeted antiangiogenic therapy. The efficacy of nivolumab for patients with RCC was established by the Checkmate 025 clinical trial. Chromophobe RCC (CRCC) represents around 5% of RCC cases, but non-clear cell RCC (non-ccRCC) subtypes were excluded from the Checkmate 025 clinical trial...
April 18, 2018: BMC Urology
https://www.readbyqxmd.com/read/29650276/classic-biphasic-pulmonary-blastoma-a-case-report-and-review-of-the-literature
#14
REVIEW
H Le Caer, E Teissier, J R Barriere, N Venissac
Pulmonary blastomas represent about 0.5% of primary pulmonary malignancies. The prognosis is poor. Standard treatment consists of surgical excision. There are no published series on which to judge the efficacy of chemotherapy or radiation therapy. We describe an unusual case of classic biphasic pulmonary blastoma (CBPC), with long-term survival despite numerous and varied cancer-related events and review the literature. Our 71-year-old Caucasian woman presented with history of blood in sputum in 2009. Right lower lobectomy yielded a diagnosis of sarcomatoid carcinoma (pneumoblastoma)...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29624700/sarcomatoid-pilomatrix-carcinoma
#15
Angel Fernandez-Flores, David S Cassarino
Pilomatrical (pilomatrix) carcinoma is a rare cutaneous adnexal tumor with matrical differentiation and recurrent and metastatic potential. Sarcomatoid pilomatrix carcinoma is a rare variant which shows a sarcomatoid component intermingling with the epithelial one. There are only four cases previously published. We present an additional case on the hand of a 78 year-old man which appeared as a 6 mm hyperkeratotic ─focally ulcerated─ plaque. A shave biopsy demonstrated a dermal infiltrative neoplasm, composed of markedly atypical-appearing basaloid cells with focal necrotic/ghost cells, as well as an intimately associated population of atypical oval to spindle-shaped cells...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29606134/tgr5-expression-in-normal-kidney-and-renal-neoplasms
#16
Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang, Weibiao Cao
BACKGROUND: The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 is found in a wide variety of tissues including the kidney. However, the patterns of TGR5 expression have not been well characterized in physiologic kidney or renal neoplasms. We explore the expression of TGR5 in benign renal tissue and renal neoplasms and assess its utility as a diagnostic marker...
April 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29581908/sarcomatoid-variant-of-urothelial-carcinoma-of-the-renal-pelvis-with-inferior-vena-cava-tumour-thrombus-a-case-report-and-literature-review
#17
Sameera Rashid, Mohammed Akhtar
Sarcomatoid variant of urothelial carcinoma (SVUC) of the renal pelvis is a rare entity. To the best of our knowledge, around 25 cases of this neoplasm have been reported in the literature to date, most of which were of high stage. The inferior vena cava tumour thrombus, which is a hallmark of renal cell carcinoma (RCC), may rarely be found in urothelial carcinoma of renal pelvis. In this report, a case of SVUC associated with tumour extension to inferior vena cava is documented. This association has been encountered in only one previously reported case...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29581844/predictive-value-of-inflammation-based-prognostic-scores-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-cytoreductive-nephrectomy
#18
Hironori Fukuda, Toshio Takagi, Tsunenori Kondo, Satoru Shimizu, Kazunari Tanabe
Inflammation-based prognostic scores are useful for predicting survival in various cancers. Here, we aimed to determine the most useful inflammation-based prognostic score for predicting survival in patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy. We retrospectively analyzed the data of 152 patients who underwent cytoreductive nephrectomy for metastatic renal cell carcinoma between 1986 and 2015. In the multivariate stepwise analysis, the combination of age, Memorial Sloan-Kettering Cancer Center score, histology, sarcomatoid change, clinical nodal stage, brain metastasis, and liver metastasis was a significant predictor for survival (Harrell's concordance index [c-index]: 0...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29562398/-clinical-features-and-prognosis-of-pulmonary-sarcomatoid-carcinoma
#19
H T Gu, J Y Zhou, T Wu, J Y Zhou
Objective: To investigate the clinical features and prognosis of patients with pulmonary sarcomatoid carcinoma (PSC). Methods: The study retrospectively reviewed the clinical, radiological, pathological characteristics and prognosis of 76 patients with PSC who were treated in the First Affiliated Hospital of Medical School of Zhejiang University from January 2011 to December 2016. Gender, age, smoking history, tumor location, tumor size, lymph node metastasis, distant metastasis, TNM staging and treatment methods were analyzed to determine the factors affecting the prognosis of PSC patients...
March 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29560759/chromophobe-renal-cell-carcinoma-with-retrograde-venous-invasion-and-gain-of-chromosome-21-potential-harbingers-of-aggressive-clinical-behavior
#20
Mohsin Jamal, Kanika Taneja, Sohrab Arora, Ravi Barod, Craig G Rogers, Jessica Sanchez, Nilesh S Gupta, Sean R Williamson
Occasionally, renal cell carcinoma (RCC) with renal vein extension spreads against the flow of blood within vein branches into the kidney, forming multifocal nodules throughout the renal parenchyma. These foci are not regarded as multiple tumors but rather reverse spread of tumor along the venous system. This intravascular spread has previously been reported in clear cell RCC and RCC unclassified. However, to our knowledge, this has never been reported in chromophobe RCC. Chromophobe RCC is a unique histologic subtype of renal cancer, generally thought to have less aggressive behavior...
March 1, 2018: International Journal of Surgical Pathology
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