keyword
https://read.qxmd.com/read/38516459/spindle-cell-carcinoma-presenting-as-a-massive-pleural-effusion
#1
Moutaz Ghrewati, Anas Mahmoud, Malina Mohtadi, Joseph Russo, Mohammad Alnabulsi, Mourad Ismail, Mehandar Kumar
The lung's sarcomatoid carcinomas (SC) are a heterogeneous sporadic group of non-small cell lung carcinomas (NSCLCs) and are very challenging to diagnose and treat. Spindle cell carcinoma (SpCC) is a very rare subset of this group. Hence, the prognosis and treatments are unclear due to the limited literature available. The presentation of this cancer varies based on the site of the neoplasm and the complications and metastases observed at the time of diagnosis. Here, we report a 73-year-old man who presented to the emergency room after two months of worsening dyspnea and fatigue...
February 2024: Curēus
https://read.qxmd.com/read/38494564/efficacy-assessment-of-post-nephrectomy-adjuvant-therapies-in-patients-with-renal-cell-carcinoma
#2
JOURNAL ARTICLE
Kaiyue Ding, Zhixuan Yang, Danyan Zhang, Lin Sun
OBJECTIVE: The objective of our study was to integrate the efficacy results of post-nephrectomy adjuvant therapies in renal cell carcinoma (RCC) patients with risk of recurrence, and attempt to determine the optimal intervention choice. METHODS: We performed standard meta-analysis procedures in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed, Embase, and Cochrane Library databases were searched from inception to 22 September 2022...
March 17, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38494556/extended-radical-resection-and-chest-wall-reconstruction-for-a-pulmonary-sarcomatoid-carcinoma-a-case-report
#3
JOURNAL ARTICLE
Yingzhi Zhao, Shaohua Xie, Haoqian Zheng, Kaixin Zhang, Xin Gao, Wenwu Liu, Wei Dai, Hongfan Yu, Qiuling Shi, Bin Hu, Qiang Li, Tianpeng Xie, Xing Wei
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a rare and highly malignant type of non-small cell lung cancer (NSCLC), for which the treatment of choice is surgery. For peripheral PSC growing outward and invading the chest wall, a complete resection of the affected lung lobes and the invaded chest wall can improve long-term prognosis. However, when the extent of the resected chest wall is large, reconstruction is often required to reduce the risk of postoperative complications. Here, we present a case of PSC invading the chest wall treated with successful extended radical resection for lung cancer and chest wall reconstruction...
March 18, 2024: Surgical Case Reports
https://read.qxmd.com/read/38492778/high-grade-non-sarcomatoid-chromophobe-renal-cell-carcinoma-a-series-of-22-cases-with-novel-molecular-features-on-a-subset
#4
JOURNAL ARTICLE
Ezra G Baraban, Roy Elias, Ming-Tseh Lin, Yasser Ged, Jing Zhu, Aparna Pallavajjala, Nirmish Singla, Tamara L Lotan, Pedram Argani, James R Eshleman, Jonathan I Epstein
Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of renal cell carcinoma, and typically exhibits indolent behavior, though a rare subset can exhibit high-grade morphological features and are associated with a poor prognosis. Although there is limited data on the molecular characteristics of metastatic and sarcomatoid ChRCC, the molecular features of high-grade non-sarcomatoid ChRCC remain unexplored. Herein, we characterize 22 cases of ChRCC with high-grade, non-sarcomatoid components...
March 14, 2024: Modern Pathology
https://read.qxmd.com/read/38492258/sarcomatoid-renal-pelvis-carcinoma-experience-of-treatment-at-a-single-institution
#5
JOURNAL ARTICLE
Tian Liu, Yu Yao, Chaoqun Geng, Fengju Guan, Guiming Zhang
OBJECTIVES: Sarcomatoid renal pelvis carcinoma (SRPC) is a rare variant of RPC. We aimed to summarize the clinicopathological features and prognostic factors of SRPC. METHODS: In this retrospective study, we collected data from 24 patients with SRPC who were treated at the Department of Urology, Affiliated Hospital of Qingdao University between 2008 and 2021. The clinicopathological features of the patients were obtained from their medical records to evaluate the diagnosis, prognostic factors, and response to systemic therapy...
March 5, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38486364/cytoreductive-nephrectomy-in-the-era-of-immune-checkpoint-inhibitors-a-u-s-fda-pooled-analysis
#6
JOURNAL ARTICLE
Jaleh Fallah, Haley Gittleman, Chana Weinstock, Elaine Chang, Sundeep Agrawal, Shenghui Tang, Richard Pazdur, Paul G Kluetz, Daniel L Suzman, Laleh Amiri-Kordestani
BACKGROUND: This pooled analysis of patient-level data from trials evaluated the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) with or without cytoreductive nephrectomy (CN) prior to a combination of immune checkpoint inhibitor (ICI) and anti-angiogenic therapy. METHODS: Five trials of ICI plus anti-angiogenic therapy were pooled. Only patients with stage 4 at initial diagnosis were included to ensure that nephrectomy was done for cytoreductive purposes and not to previously treat an earlier stage of disease...
March 14, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38483580/predicting-individual-outcomes-after-radical-cystectomy-in-urothelial-variants-with-cancer-of-the-bladder-risk-assessment-cobra-score
#7
JOURNAL ARTICLE
Caio Vinícius Suartz, Maurício Dener Cordeiro, Luiz Antonio Assan Botelho, Fábio Pescarmona Gallucci, David Hamilton Cho, Filipe de Arruda Pessoa, Flávio Rossi da Silva, Mateus Silva Santos Costa, Leonardo Cardili, François Audenet, José Maurício Mota, Paul Toren, William Carlos Nahas, Leopoldo Alves Ribeiro-Filho
OBJECTIVE: To validate the Cancer of the Bladder Risk Assessment (COBRA) score in patients with urothelial variants. METHODS: Epidemiological, clinical, radiological, and anatomopathological data were collected from patients with urothelial carcinoma who underwent radical cystectomy at the Institute of Cancer of São Paulo between May 2008 and December 2022. Patients with the presence of at least 10% of any urothelial variants in the radical cystectomy specimens' anatomopathological exam were included in the study...
March 14, 2024: World Journal of Urology
https://read.qxmd.com/read/38482675/trop-2-nectin-4-and-predictive-biomarkers-in-sarcomatoid-and-rhabdoid-bladder-urothelial-carcinoma
#8
JOURNAL ARTICLE
Matteo Brunelli, Stefano Gobbo, Giorgio Malpeli, Grazia Sirgiovanni, Claudia Caserta, Enrico Munari, Simona Francesconi, Anna Caliò, Guido Martignoni, Alessia Cimadamore, Alessandro Veccia, Alessandro Antonelli, Marcello Tucci, Francesco Pierconti, Isabelle Malak Hattab, Albino Eccher, Stefano Ascani, Michele Milella, Lucio Buffoni, Liang Cheng, Sergio Bracarda
INTRODUCTION: The surface protein TROP-2/TACSTD2 and the cell adhesion protein NECTIN-4/NECTIN4 are responsible for the efficacy of anticancer therapies based on antibody-drug conjugates (ADC) targeting intracellular microtubules. In contrast with common histologic subtypes of bladder urothelial carcinoma (BUC), little is known of TROP-2 and NECTIN-4 expression in sarcomatoid and rhabdoid BUC. AIMS: In this study, we aimed to analyze TROP-2 and NECTIN-4 expression and additional predictive biomarkers by immunohistochemistry and fluorescence in situ hybridization (FISH) on 35 undifferentiated BUC (28 sarcomatoid and 7 rhabdoid)...
February 2024: Pathologica
https://read.qxmd.com/read/38480032/stratification-of-patients-with-renal-cell-carcinoma-by-the-abundance-of-sarcomatoid-features-reveals-differences-in-survival-and-the-underlying-pathobiology
#9
JOURNAL ARTICLE
Nicholas J Salgia, Wilhelm M Aubrecht, Lin Wang, Bebu Ram, Brianna J Wasik, Adil Khan, Kristopher Attwood, Jorge Daza, Mark D Long, Kevin H Eng, Bo Xu, Jason B Muhitch, Eric C Kauffman
Sarcomatoid renal cell carcinoma (sRCC) is histologically heterogeneous, with variable sarcomatoid amounts intermixed within epithelial carcinoma. However, the current classification for this aggressive disease is homogeneous and agnostic to the sarcomatoid proportion. We investigated whether sRCC subclassification has prognostic value and can reveal the biology underlying dedifferentiation and its clinical aggressiveness. On the basis of the intratumoral abundance of sarcomatoid features, cases were classified as sarcomatoid-high (≥10% sarcomatoid features) or sarcomatoid-low (<10% sarcomatoid features) in a cohort of 104 consecutive patients with sRCC undergoing nephrectomy at a single center...
March 12, 2024: European Urology Oncology
https://read.qxmd.com/read/38459823/genomic-analysis-of-an-aggressive-hepatic-leiomyosarcoma-case-following-treatment-for-hepatocellular-carcinoma
#10
Yuto Numata, Noriyuki Akutsu, Masashi Idogawa, Kohei Wagatsuma, Yasunao Numata, Keisuike Ishigami, Tomoya Nakamura, Takehiro Hirano, Yujiro Kawakami, Yoshiharu Masaki, Ayako Murota, Shigeru Sasaki, Hiroshi Nakase
A 70-year-old man undergoing treatment for immunoglobulin G4-related disease developed a liver mass on computed tomography during routine imaging examination. The tumor was located in the hepatic S1/4 region, was 38 mm in size, and showed arterial enhancement on dynamic contrast-enhanced computed tomography. We performed a liver biopsy and diagnosed moderately differentiated hepatocellular carcinoma. The patient underwent proton beam therapy. The tumor remained unchanged but enlarged after 4 years...
March 9, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38455785/adrenocortical-sarcomatoid-carcinoma-revealed-by-an-adrenal-incidentaloma-a-case-report
#11
Samia Bentaleb, Ghita Bourkadi, Hayat Aynaou, Houda Salhi
Sarcomatoid carcinoma of the adrenal gland represents an exceedingly unusual and highly aggressive form of adrenocortical carcinoma. Its diagnosis is challenging because of its dual histological components: epithelial and sarcomatoid. Most patients are diagnosed at a late stage and die within months of diagnosis. We report on a 51-year-old man who had adrenocortical sarcomatoid cancer. It was diagnosed as a unilateral left adrenal incidentaloma discovered on a CT scan carried out for abdominal pain. By means of this case, we will present the clinical, radiological, and histological profile of this tumor...
February 2024: Curēus
https://read.qxmd.com/read/38455710/histological-sarcomatoid-transformation-in-a-lung-adenocarcinoma-patient-following-immune-checkpoint-blockade
#12
Xiuju Liang, Yaping Guan, Baocheng Wang, Xiaohong Liu, Jun Wang
Histological transformation is a phenomenon that is well described as one of the causes of tyrosine kinase inhibitor resistance in oncogene-driven non-small-cell lung cancer (NSCLC). The use of immune checkpoint inhibitors (ICIs) as a potential mechanism of acquired resistance to immunotherapy in NSCLC to small-cell lung cancer was also recently found. Here, we report the histological transformation of sarcomatoid carcinoma and metastasis in a lung adenocarcinoma patient without targetable genetic alterations who experienced long-term disease remission after nivolumab therapy...
2024: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/38453449/-a-case-of-multidomain-integrated-treatment-strategy-%C3%A2-for-complex-primary-pulmonary-sarcomatoid-carcinoma
#13
JOURNAL ARTICLE
Xiaosen Huo, Hang Zou, Yanyan Dong, Yuan Li, Lingjie Bian, Lei Li, Hongwu Wang
Pulmonary sarcomatoid carcinoma (PSC) is a rare and highly malignant tumor, which includes the following five pathologic types: pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma. The onset of PSC is occult with non-specific clinical symptoms and signs. The clinical manifestations include irritating cough, bloody sputum, dyspnea, chest pain and so on, which are closely related to the growth and invasion site of the tumor. PSC tends to metastasize early, so most patients are already in local advanced stage or advanced stage with a median survival of 9 months at the time of hospital visit...
February 20, 2024: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://read.qxmd.com/read/38448211/emerging-and-under-recognised-patterns-of-colorectal-carcinoma-morphologies-a-comprehensive-review
#14
JOURNAL ARTICLE
Yuho Ono, Osman Yilmaz
While the overwhelming majority of colorectal carcinomas (CRC) are diagnosed as adenocarcinoma not otherwise specified, there are numerous under-recognised morphologic patterns of CRC. These patterns are recognised by the WHO, appear in reporting manuals for the American Joint Committee of Cancer, and/or are listed on synoptic reports, while many other variants have either fallen out of favour or are emerging as future bona fide patterns. Herein, we discuss 13 variants: serrated adenocarcinoma, micropapillary adenocarcinoma, medullary carcinoma, neuroendocrine carcinoma, mucinous adenocarcinoma, signet-ring cell carcinoma, adenosquamous carcinoma, adenoma-like adenocarcinoma, lymphoglandular complex-like CRC, carcinoma with sarcomatoid components, cribriform-comedo-type adenocarcinoma, undifferentiated carcinoma and low-grade tubuloglandular adenocarcinoma...
March 6, 2024: Journal of Clinical Pathology
https://read.qxmd.com/read/38445157/sarcomatoid-carcinoma-a-clinicopathological-dichotomy
#15
Rhitam Ghosal, Durba Roychowdhury, Rudra Prasad Chatterjee, Mehebuba Sultana, Sangeeta Sinha
Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is an uncommon biphasic malignant neoplasm occurring mainly in the upper aerodigestive tract. It has spindled or pleomorphic tumor cells simulating a true sarcoma with epithelial origin. WHO recognized this tumor as an aggressive variant of squamous cell carcinoma and further designated it as spindle cell carcinoma. This neoplasm is known for its propensity of recurrence and metastasis reinforcing the importance of its proper diagnosis. In our case report, we talk about sarcomatoid carcinoma involving the oral cavity having a high metastasizing rate according to histopathological and immunohistochemical features...
February 2024: Curēus
https://read.qxmd.com/read/38443238/the-prognostic-role-of-histomorphological-subtyping-in-nonmetastatic-papillary-renal-cell-carcinoma-after-curative-surgery-is-subtype-really-irrelevant-a-propensity-score-matching-analysis-of-a-multi-institutional-real-life-data
#16
JOURNAL ARTICLE
Selcuk Erdem, Riccardo Bertolo, Riccardo Campi, Umberto Capitanio, Daniele Amparore, Umberto Anceschi, Maria Carme Mir, Eduard Roussel, Nicola Pavan, Umberto Carbonara, Onder Kara, Tobias Klatte, Michele Marchioni, Angela Pecoraro, Stijn Muselaers, Laura Marandino, Pietro Diana, Leonardo Borregales, Carlotta Palumbo, Hannah Warren, Zhenjie Wu, Anna Calio, Chiara Ciccarese, Enes Degirmenci, Resat Aydin, Giacomo Rebez, Luigi Schips, Giuseppe Simone, Andrea Minervini, Sergio Serni, Faruk Ozcan
BACKGROUND AND AIM: The role of histomorphological subtyping is an issue of debate in papillary renal cell carcinoma (papRCC). This multi-institutional study investigated the prognostic role of histomorphological subtyping in patients undergoing curative surgery for nonmetastatic papRCC. PATIENTS AND METHODS: A total of 1,086 patients undergoing curative surgery were included from a retrospectively collected multi-institutional nonmetastatic papRCC database. The patients were divided into 2 groups based on histomorphological subtyping (type 1, n = 669 and type 2, n = 417)...
March 4, 2024: Urologic Oncology
https://read.qxmd.com/read/38433056/-clinicopathological-and-molecular-characteristics-of-esophageal-carcinoma-with-ductal-differentiation-analysis-of-17-cases
#17
JOURNAL ARTICLE
W J Jiang, S Ao, Y Y Cui, L Lu, C N Wang
Objective: To investigate the clinicopathological features and molecular genetic characteristics of esophageal carcinoma with ductal differentiation, and to summarize the experiences in its diagnosis and treatment. Methods: A total of 17 cases of esophageal carcinoma with ductal differentiation diagnosed in Ningbo Clinical Pathological Diagnosis Center, Ningbo, China from June 2011 to December 2022 were collected. The clinical information and pathological diagnosis was reviewed. The tumor histological features and immunohistochemical results were analyzed...
March 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/38420021/-18-f-fdg-pet-ct-imaging-in-pulmonary-sarcomatoid-carcinoma
#18
JOURNAL ARTICLE
Zhe-Huang Luo, Xiao-Yan Luo, Wan-Ling Qi, Qian Liu
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a rare highly aggressive and poorly differentiated non-small cell carcinoma, and little is known about the information on the usefulness of 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT). We investigated the clinical and 18 F-FDG PET/CT features of PSC. METHODS: We retrospectively analyzed 25 consecutive PSC patients who had undergone 18 F-FDG PET/CT. Demographic data, PET/CT findings before treatment, pathological features, and prognosis in these patients were investigated to define correlates between maximal standard uptake value (SUVmax) and clinicopathological parameters...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38414747/case-report-successful-treatment-of-advanced-pulmonary-sarcomatoid-carcinoma-with-bubib-alk-rearrangement-and-kras-g12c-mutation-by-sintilimab-combined-with-anlotinib
#19
Nana Huang, Tianhao Qu, Chunxia Zhang, Jia Li
Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small cell lung cancer (NSCLC) that is characterized by poor differentiation and invasiveness. According to the World Health Organization, PSC exhibits sarcoma or sarcomatoid differentiation and typically presents with an insidious onset, lacking specific symptoms and signs. It is associated with high malignancy, early metastasis, short survival time, and a poor prognosis. Treatment for PSC follows a similar approach to NSCLC; however, it presents significant challenges due to its high resistance to chemotherapy...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38411691/renal-cell-carcinoma-and-venous-tumor-thrombus-predicting-sarcomatoid-dedifferentiation-through-preoperative-ivim-based-mr-imaging
#20
JOURNAL ARTICLE
Jian Zhao, Xiaohui Ding, Shaopeng Zhou, Meifeng Wang, Cheng Peng, Xu Bai, Xiaojing Zhang, Kan Liu, Xin Ma, Xu Zhang, Haiyi Wang
PURPOSE: To evaluate the value of preoperative intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and conventional MRI indicators in identifying sarcomatoid dedifferentiation in renal cell carcinoma (RCC) and tumor thrombus. METHODS: From September 2016 to April 2023, consecutive patients with RCC and tumor thrombus who received routine MRI examination and IVIM-DWI before radical resection were enrolled prospectively. Kaplan-Meier method with log-rank test was used to calculate and compare the survival probability...
February 27, 2024: Abdominal Radiology
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