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sarcomatoid carcinoma

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https://www.readbyqxmd.com/read/28912138/sarcomatoid-renal-cell-carcinoma-the-apple-doesn-t-fall-far-from-the-tree
#1
Paulo Bergerot, Neeraj Agarwal, Sumanta Kumar Pal, Jeremy O Jones
The most comprehensive sequencing effort of sarcomatoid renal cell carcinoma (sRCC) to date reinforces the notion that the sarcomatoid component is closely related to the epithelial component of the cancer. This work also challenges the notion that sRCC evolves from low grade RCC and identifies potential mediators of sarcomatoid differentiation.
September 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28898989/role-of-histone-h3k27-trimethylation-loss-as-a-marker-for-malignant-peripheral-nerve-sheath-tumor-in-fine-needle-aspiration-and-small-biopsy-specimens
#2
Jeffrey K Mito, Xiaohua Qian, Leona A Doyle, Jason L Hornick, Vickie Y Jo
Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28892918/sarcomatoid-carcinoma-of-renal-pelvis-with-abundant-heterologous-osteosarcomatous-element-a-case-report
#3
Mona Lisa, Guddi Rani Singh, Richa Madhawi, Bipin Kumar, Zeenat Sarmadi Imam
A 47-year-old male presented with haematuria and flank pain for two weeks. Ultrasonography and renal scan revealed a poorly functioning left kidney with multiple calculi. Simple nephrectomy was performed and the specimen revealed a mass in his renal pelvis which showed both carcinomatous and sarcomatous components on microscopy. The sarcomatous component consisted of diffuse pleomorphic osteoblasts with intervening lacy osteoid, giving an osteosarcoma-like appearance. These areas of tumour were strongly positive for vimentin and osteopontin...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891087/elucidation-of-salvage-laryngectomy-pathologic-and-clinical-variables-to-guide-further-treatment-intensification-investigation
#4
Joseph Scharpf, Matthew Ward, David Adelstein, Shlomo Koyfman, Mingsi Li
OBJECTIVE/HYPOTHESIS: There are limited treatment options beyond surgical salvage for patients who fail nonoperative treatment for laryngeal squamous cell carcinoma. In this study, we examine the failure patterns after surgical salvage and the potential pathologic and clinical prognostic variables that might guide further postoperative intensification investigation. STUDY DESIGN: Retrospective analysis at a tertiary academic referral center. METHODS: From an institutional review board-approved institutional head and neck cancer registry, a consecutive series of 147 patients who underwent salvage laryngectomy for squamous cell cancer recurrence or persistence after radiotherapy with or without chemotherapy between May 1995 and May 2016 were identified...
September 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28890070/oligometastatic-renal-cell-carcinoma-with-sarcomatoid-differentiation-demonstrating-variable-imaging-phenotypes-on-68-ga-psma-and-18-f-fdg-pet-ct-a-case-report-and-review-of-the-literature
#5
David P Nadebaum, Michael S Hofman, Catherine A Mitchell, Shankar Siva, Rodney J Hicks
No abstract text is available yet for this article.
August 23, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28882777/secondary-urethral-malignancies-following-prostate-brachytherapy
#6
Shree Agrawal, John M Lacy, Herman Bagga, Kenneth W Angermeier, Jay Ciezki, Rahul D Tendulkar, Chandana A Reddy, Hadley M Wood
OBJECTIVE: To understand urethral secondary malignancies among patients treated with brachytherapy (BRT) for primary prostate cancer. METHODS: Institutional retrospective review identified 13 patients evaluated from 2003-2014 with urethral cancer and prior history of BRT monotherapy for prostate cancer. All patients were biochemically free of their primary disease and developed histologically distinct RASM from primary tumor via pathologic confirmation. BRT characteristics, patient age, presentation, staging work-up and clinical course were evaluated...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/28877065/hpv-related-multiphenotypic-sinonasal-carcinoma-an-expanded-series-of-49-cases-of-the-tumor-formerly-known-as-hpv-related-carcinoma-with-adenoid-cystic-carcinoma-like-features
#7
Justin A Bishop, Simon Andreasen, Jen-Fan Hang, Martin J Bullock, Tiffany Y Chen, Alessandro Franchi, Joaquin J Garcia, Douglas R Gnepp, Carmen R Gomez-Fernandez, Stephan Ihrler, Ying-Ju Kuo, James S Lewis, Kelly R Magliocca, Stefan Pambuccian, Ann Sandison, Emmanuelle Uro-Coste, Edward Stelow, Katalin Kiss, William H Westra
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a peculiar neoplasm that is restricted to the sinonasal tract, exhibits features of both a surface-derived and salivary gland carcinoma (particularly adenoid cystic carcinoma), and is associated with high-risk HPV. Given the limited number of published cases, the full clinicopathologic spectrum of this neoplasm is unclear. Here, we present an updated experience of 49 cases...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28870517/phase-2-trial-of-capecitabine-gemcitabine-and-bevacizumab-in-sarcomatoid-renal-cell-carcinoma
#8
Abhishek Maiti, Maryam Nemati-Shafaee, Pavlos Msaouel, Lance C Pagliaro, Eric Jonasch, Nizar M Tannir, Amishi Y Shah
BACKGROUND: Patients with sarcomatoid renal-cell carcinomas (sRCC) have poor outcomes and limited treatment options. Preclinical and clinical data suggest susceptibility to cytotoxic agents and vascular endothelial growth factor-targeted therapies. We designed a phase 2 trial to evaluate the efficacy and safety of capecitabine, gemcitabine, and bevacizumab in sRCC. PATIENTS AND METHODS: Patients with metastatic or unresectable sRCC were eligible for inclusion. Patients received oral capecitabine 800 mg/m(2) twice daily on days 1 to 21 of a 28-day cycle, intravenous gemcitabine 900 mg/m(2) on days 1 and 15, and intravenous bevacizumab 10 mg/kg on days 1 and 15...
August 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28833389/morphologic-spectrum-of-renal-cell-carcinoma-unclassified-an-analysis-of-136-cases
#9
Carmen M Perrino, David J Grignon, Sean R Williamson, Muhammad T Idrees, John N Eble, Liang Cheng
AIMS: Renal cell carcinoma, unclassified (RCCU) is a category that includes a morphologically and biologically heterogeneous group of tumors that are unable to be diagnosed as other well-defined entities. We aim to describe the morphologic findings of tumors within this category and to determine the most frequent morphologic features leading to classification difficulty. METHODS AND RESULTS: One hundred and thirty-six cases of RCCU were examined. Patients ranged in age from 23 to 87 years...
August 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28832979/programmed-cell-death-ligand-1-and-tumor-infiltrating-lymphocyte-status-in-patients-with-renal-cell-carcinoma-and-sarcomatoid-dedifferentiation
#10
Fumi Kawakami, Kanishka Sircar, Jaime Rodriguez-Canales, Bryan M Fellman, Diana L Urbauer, Pheroze Tamboli, Nizar M Tannir, Eric Jonasch, Ignacio I Wistuba, Christopher G Wood, Jose A Karam
BACKGROUND: The immune profile of sarcomatoid renal cell carcinoma (sRCC), including the programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) status, has not been well characterized. METHODS: An immunohistochemical digital analysis of PD-L1, PD-1, CD4, and CD8 was performed on nephrectomy specimens from 118 sRCC patients and 92 nonsarcomatoid clear cell renal cell carcinoma (ccRCC) patients. The clinical characteristics of the population were compared between sRCC and ccRCC...
August 22, 2017: Cancer
https://www.readbyqxmd.com/read/28827101/sarcomatoid-carcinoma-associated-with-small-cell-carcinoma-of-the-urinary-bladder-a-series-of-28-cases
#11
Yuly Ramirez Urrea, Jonathan I Epstein
The association of sarcomatoid carcinoma (SC) with small cell carcinoma (SCC) has not been systematically studied. We identified 39 consult cases between 2001-2016 with available slides for review in 28 cases. There were 19 men and 9 women [mean age: 78years (51-89)]. In 26 (92.8%) cases, the sarcomatoid component had nonspecific malignant spindle cells, 4 (14%) chondrosarcoma, 2 (7%) myxoid sarcomatous, 1 (3.5%) osteosarcoma, and 1 (3.5%) rhabdomyosarcoma. The predominant component was in 11 (39%) cases SCC, 6 (21%) urothelial carcinoma, 3 (10%) sarcomatoid, and 8 (29%) equal sarcomatoid and SCC...
August 18, 2017: Human Pathology
https://www.readbyqxmd.com/read/28814981/cpg-location-and-methylation-level-are-crucial-factors-for-the-early-detection-of-oral-squamous-cell-carcinoma-in-brushing-samples-using-bisulfite-sequencing-of-a-13-gene-panel
#12
Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini
BACKGROUND: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. The purpose of this study was to evaluate the diagnostic value of methylation level in a set of 18 genes by bisulfite next-generation sequencing...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28803448/microvascular-and-lymphovascular-tumor-invasion-are-associated-with-poor-prognosis-and-metastatic-spread-in-renal-cell-carcinoma-a-validation-study-in-clinical-practice
#13
Jens Bedke, Johannes Heide, Silvia Ribback, Steffen Rausch, Michela de Martino, Marcus Scharpf, Andrea Haitel, Uwe Zimmermann, Maik Pechoel, Hussam Alkhayyat, Shahrokh F Shariat, Frank Dombrowski, Arnulf Stenzl, Martin Burchardt, Tobias Klatte, Nils Kroeger
OBJECTIVE: To validate microvascular (MVI) and lymphovascular (LVI) invasion as a prognostic factor in renal cell carcinoma patients (pts.) MATERIALS AND METHODS: Data of patients with RCC who underwent radical or nephron sparing surgery were prospectively collected from three academic centers. The occurrence of MVI and LVI was determined with standard staining protocols by experienced pathologists at the time of diagnosis. The association of MVI and LVI with clinicopathological data, metastatic spread and cancer-specific survival (CSS) was evaluated with Fisher's exact tests, binary logistic regression analyses and univariable and multivariable Cox proportional hazard regression models...
August 13, 2017: BJU International
https://www.readbyqxmd.com/read/28801324/mechanical-thrombectomy-for-repeated-cerebral-tumor-embolism-from-a-thoracic-sarcomatoid-carcinoma
#14
Raoul Pop, Dan Mihoc, Monica Manisor, Johann Sebastian Richter, Veronique Lindner, Ralf Janssen-Langenstein, Mihaela Simu, Valerie Wolff, Remy Beaujeux
Cerebral embolism originating from intracardiac tumors represents a rare cause of stroke and has been documented in both adult and pediatric populations. We present a patient recently diagnosed with a right pulmonary hilum tumor, invading the pulmonary veins and the left atrium. Two consecutive episodes of large cerebral vessel occlusion in separate vascular territories occurred in the same day and were treated by mechanical thrombectomy. Embolic material retrieved on both occasions contained tumor fragments with peripheral endothelialization...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28798002/sarcomatoid-carcinoma-of-the-maxilla-a-case-report-with-literature-review
#15
Lahcen Khalfi, Yassine Ziani, Mouna Kairouani, Odry Agbessi, Mohammed Kamal Fiqhi, Alae Guerrouani, Karim El Khatib
Sarcomatoid carcinoma is a very rare malignant and aggressive tumor that can involve the maxillary sinus. We report the case of a 46 y/o male who presented a tumor of the right maxillary sinus with extension to the right nasal cavity. The diagnosis of sarcomatoid carcinoma was set by histology and immunohistochemistry. The patient received concomitant cisplatin based chemoradiotherapy with no response after 3 months of treatment. He died 6 months later. Through the present case and the review of literature we discuss all aspects of this entity: clinical presentation, differential diagnoses, pathology, treatment and prognosis...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28795841/serous-carcinoma-mimicking-primary-urothelial-carcinoma-on-clinical-evaluation-and-pathology-a-potential-diagnostic-pitfall
#16
Leili Mirsadraei, Alexey Hodkoff, Karra Jones, Ahmed Shabaik, A Karim Kader, Cheryl C Saenz, Rodolfo Montironi, David E Tacha, Oluwole Fadare, Donna E Hansel
CONTEXT: - Serous carcinoma of the gynecologic tract often involves the external bladder wall and can occasionally mimic primary urothelial carcinoma of the bladder. OBJECTIVE: - To define the spectrum of morphologic and immunohistochemical features that characterize serous carcinoma involving the bladder wall and its distinction from urothelial carcinoma. DESIGN: - We reviewed all cases of serous carcinoma secondarily involving the bladder wall from the University of California San Diego and Polytechnic Institute for histopathologic and immunohistochemical features...
August 10, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28782639/the-differential-diagnosis-between-pleural-sarcomatoid-mesothelioma-and-spindle-cell-pleomorphic-sarcomatoid-carcinomas-of-the-lung-evidence-based-guidelines-from-the-international-mesothelioma-panel-and-the-mesopath-national-reference-center
#17
Alberto M Marchevsky, Nolwenn LeStang, Kenzo Hiroshima, Giuseppe Pelosi, Richard Attanoos, Andrew Churg, Lucien Chirieac, Sanja Dacic, Aliya Husain, Andras Khoor, Sonja Klebe, Silvie Lantuejoul, Victor Roggli, Jean-Michel Vignaud, Birgit Weynand, Jennifer Sauter, Douglas Henderson, Kazuki Nabeshima, Francoise Galateau-Salle
Immunohistochemistry is used to distinguish sarcomatoid malignant mesotheliomas (SMM) from spindle cell and pleomorphic carcinomas (SPC) but there are no guidelines on how to interpret cases that show overlapping or equivocal immunohistochemical findings. A systematic literature review of the immunophenotype of these lesions was performed and the experience with 587 SMM and 46 SPC at MESOPATH was collected. Data were analyzed with Comprehensive Meta-Analysis 2.0 software (Biostast, Englewood N.J.). There were insufficient data to evaluate the differential diagnosis between SPC and localized SMM or peritoneal SMM...
August 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28781811/unusual-recurrent-tongue-spindle-cell-carcinoma-with-marked-anaplasia-occurring-at-the-site-of-glossectomy-for-a-well-differentiated-squamous-cell-carcinoma-a-case-report
#18
Kohei Okuyama, Shuichi Fujita, Souichi Yanamoto, Tomofumi Naruse, Yuki Sakamoto, Akiko Kawakita, Keisuke Omori, Hiroki Tsuchihashi, Masahiro Umeda
Spindle cell carcinoma (SpCC), which predominantly arises in the oral, pharyngeal and laryngeal mucosal tissues, is composed of a mixture of squamous and sarcomatoid components. The present study describes the case of a 62-year-old woman with SpCC recurrence 4 years after an initial surgery to remove a well-differentiated primary squamous cell carcinoma (SCC) of the tongue. The recurrent tumor was spherical and located deep within the tongue tissue, which differs from the typical manifestation of ulcerated masses of the mucosa...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28778070/the-association-between-renal-sinus-fat-area-and-the-progression-free-survival-in-chinese-non-metastatic-clear-cell-renal-cell-carcinoma-patients
#19
Haichao Huang, Shi Chen, Wei Yu, Zirong Ye, Wei Li, Jinchun Xing, Xiurong Wu
In this retrospective study, we evaluated the association between renal sinus fat area (RSFA) and survival in 268 Chinese non-metastatic clear-cell renal cell carcinoma (ccRCC) patients. Patients with high RSFA exhibited better progression-free survival than those with low RSFA in both univariable (HR: 0.240; 95% CI: 0.119-0.482; p < 0.001) and multivariable (HR: 0.432; 95% CI: 0.369-2.749; p = 0.027) analyses. A propensity-score matched (PSM) analysis using Kaplan-Meier curves confirmed our findings (log-rank test; p = 0...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28749793/pax8-expression-in-solitary-fibrous-tumor-a-potential-diagnostic-pitfall
#20
David Ullman, Jennifer Gordetsky, Gene P Siegal, Carlos N Prieto-Granada, Shi Wei, Todd M Stevens
PAX8 is used as a diagnostic aid in classifying retroperitoneal (RP) spindle cell tumors. PAX8 positivity in a spindled RP tumor is typically associated with sarcomatoid renal cell carcinoma (SRCC). However, PAX8 expression in solitary fibrous tumor (SFT), a tumor not uncommon to the RP, has not been extensively studied. We investigated the expression of PAX8 in SFTs and other spindle cell RP tumors. We collected 30 SFT, 23 SRCC, 11 gastrointestinal stromal tumors, 2 synovial sarcomas, 6 dedifferentiated liposarcomas (DDLS), 4 well differentiated liposarcomas (WDLS), and select other tumors...
July 26, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
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