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https://www.readbyqxmd.com/read/28444411/-acute-liver-failure
#1
A Koch, C Trautwein, F Tacke
Acute liver failure (ALF) is a rare, but life-threatening disease that is characterized by the acute onset of jaundice, coagulopathy, and hepatic encephalopathy (HE) in patients without pre-existing liver disease. Main causes in Germany are drug toxicity, acetaminophen overdose, and viral hepatitis (A, B, E). For the initial assessment of patients with ALF and the diagnostic algorithm, the early detection of HE, exclusion of liver cirrhosis, immediate diagnosis of the underlying etiology, and evaluation for the necessity of liver transplantation (LT) are critical...
April 25, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28442156/treatment-decision-making-in-ductal-carcinoma-in-situ-a-mixed-methods-systematic-review-of-women-s-experiences-and-information-needs
#2
REVIEW
Claudia Rutherford, Rebecca Mercieca-Bebber, Phyllis Butow, Jenny Liang Wu, Madeleine T King
OBJECTIVE: Decision-making in ductal carcinoma in situ (DCIS) is complex due to the heterogeneity of the disease. This study aimed to understand women's experience of making treatment decisions for DCIS, their information and support needs, and factors that influenced decisions. METHODS: We searched six electronic databases, conference proceedings, and key authors. Two reviewers independently applied inclusion and quality criteria, and extracted findings. Thematic analysis was used to combine and summarise findings...
April 15, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28432696/systematic-review-of-self-management-interventions-for-people-with-eczema
#3
REVIEW
M J Ridd, A J L King, E Le Roux, A Waldecker, A L Huntle
Eczema is a common, long-term condition but inadequate support and information can lead to poor adherence and treatment failure. We have reviewed the international literature of interventions designed to promote self-management in adults and children with eczema. MEDLINE, MEDLINE in process, EMBASE, CINAHL and GREAT were searched from their inception to August 2016 for randomised controlled trials. Two authors independently applied eligibility criteria, assessed risk of bias for all included studies and extracted data...
April 22, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28416780/new-onset-epilepsy-in-the-elderly-clinical-radiological-and-electroencephalographic-features-and-treatment-responses
#4
Erum M Shariff, Fahd A AlKhamis
OBJECTIVE: To evaluate new onset epilepsy characteristics, etiology, radiological and electroencephalographic features and to document treatment response in the elderly. METHODS: This was a retrospective study carried out in King Fahd Medical City, Riyadh, Kingdom of Saudi Arabia, from 2010 to 2013. Medical records were searched to recruit patients. Hundred and nineteen patients were enrolled who fulfill the inclusion criteria. Clinical data with respect to seizure semiology, etiology, electroencephalographic findings, radiological findings, co-morbidities, and anti-epileptic drug (AED) therapy were assessed...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28414804/cyclosporine-a-alters-expression-of-renal-micrornas-new-insights-into-calcineurin-inhibitor-nephrotoxicity
#5
Jennifer L Gooch, Clayton King, Cynthia E Francis, Paul S Garcia, Yun Bai
Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation. However, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), have significantly hindered their use. Specifically, nephrotoxicity, which is associated with tubulointerstitial fibrosis, inflammation, and podocyte damage, affects up to half of all transplant patients. Calcineurin is involved in many aspects of kidney development and function; therefore, mechanisms of CsA-induced nephrotoxicity are complex and not yet fully understood...
2017: PloS One
https://www.readbyqxmd.com/read/28414745/mapping-the-srs-22r-questionnaire-onto-the-eq-5d-5l-utility-score-in-patients-with-adolescent-idiopathic-scoliosis
#6
Carlos King Ho Wong, Prudence Wing Hang Cheung, Dino Samartzis, Keith Dip-Kei Luk, Kenneth M C Cheung, Cindy Lo Kuen Lam, Jason Pui Yin Cheung
This is a prospective study to establish prediction models that map the refined Scoliosis Research Society 22-item (SRS-22r) onto EuroQoL-5 dimension 5-level (EQ-5D-5L) utility scores in adolescent idiopathic scoliosis (AIS) patients. Comparison of treatment outcomes in AIS can be determined by cost-utility analysis. However, the mainstay spine-specific health-related quality of life outcome measure, the SRS-22r questionnaire does not provide utility assessment. In this study, AIS patients were prospectively recruited to complete both the EQ-5D-5L and SRS-22r questionnaires by trained interviewers...
2017: PloS One
https://www.readbyqxmd.com/read/28396972/prevalence-and-associated-factors-of-obstructive-sleep-apnea-in-morbidly-obese-patients-undergoing-bariatric-surgery
#7
Weerapat Kositanurit, Dittapol Muntham, Suthep Udomsawaengsup, Naricha Chirakalwasan
PURPOSE: Our goal in this study is to determine the prevalence and associated factors of obstructive sleep apnea (OSA) in morbidly obese patients undergoing bariatric surgery. METHODS: This descriptive study was conducted at King Chulalongkorn Memorial Hospital from 2007 to 2015. Data of morbidly obese patients who underwent bariatric surgery were included using ICD-10 code for principle diagnosis "morbid obesity" (E668) and ICD-9 code for "bariatric surgery" (4389, 4438, 4439)...
April 11, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28379285/identifying-an-early-indicator-of-drug-efficacy-in-patients-with-metastatic-colorectal-cancer-a-prospective-evaluation-of-circulating-tumor-cells-18f-fluorodeoxyglucose-positron-emission-tomography-and-the-recist-criteria
#8
B Ma, A D King, L Leung, K Wang, A Poon, W M Ho, F Mo, C M L Chan, A T C Chan, S C Cesar Wong
Background: : This study investigated the predictive and prognostic significance of assessing early drug response with both positron-emission computerized tomography (PET-CT) and circulating tumor cells (CTCs) in patients receiving first-line chemotherapy for metastatic colorectal cancer (mCRC). Patients and Method: : Eligible patients had PET-CT and CTC analysis at baseline and 4 to 6 weeks after starting chemotherapy, and then a CT scan at 10 to 12 weeks to assess the Response Evaluation Criteria In Solid Tumors (RECIST) response...
March 30, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28377541/depression-and-associated-factors-in-hospitalized-elderly-a-cross-sectional-study-in-a-saudi-teaching-hospital
#9
Sultan Hassan Alamri, Abdulaziz Ihsan Bari, Abdulrahman Talal Ali
BACKGROUND: Depression in the elderly is a serious and often underdiagnosed psychiatric disorder that has been linked to adverse outcomes in the hospital setting. OBJECTIVES: To determine the prevalence of depression and possible associated factors among hospitalized elderly. DESIGN: An analytical cross-sectional study. SETTINGS: Medical and surgical wards of King Abdulaziz University Hospital, Jeddah, Saudi Arabia. PATIENTS AND METHODS: The study included 200 consecutively hospitalized patients aged 60 years and older...
March 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28369670/effect-of-metabolic-syndrome-on-the-mobility-benefit-of-a-structured-physical-activity-intervention-the-lifestyle-interventions-and-independence-for-elders-randomized-clinical-trial
#10
Anda Botoseneanu, Haiying Chen, Walter T Ambrosius, Heather G Allore, Stephen Anton, Sara C Folta, Abby C King, Barbara J Nicklas, Bonnie J Spring, Elsa S Strotmeyer, Thomas M Gill
OBJECTIVES: To test whether structured physical activity (PA) is associated with a greater reduction in major mobility disability (MMD) in older persons with metabolic syndrome (MetS) than in those without. DESIGN: Data from the Lifestyle Interventions and Independence for Elders (LIFE) Study, a multicenter randomized trial of 1,635 persons with assessments every 6 months (average 2.7 years). SETTING: Eight U.S. centers. PARTICIPANTS: Sedentary men and women aged 70 to 89 with functional limitations (N = 1,535); 100 participants were excluded because of missing MetS data...
March 28, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28369436/first-international-public-health-film-competition-2016-reflections-on-the-development-and-use-of-competition-judging-criteria
#11
U Hoang, P Luna, P Russell, L Bergonzi-King, J Ashton, C McCarthy, H Donovan, P Inman, O Seminog, S Botchway
Background: Film competitions can be a helpful method to understand issues of quality in health films. In this paper, we describe the development and use of explicit quality criteria to identify the 'best' films for the first ever international public health film competition. Methods: A film selection committee encompassing a range of stakeholders was compiled. The committee drew up 10 explicit quality criteria to judge films drawing upon other film festival's selection criteria...
March 25, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28367168/prevalence-of-irritable-bowel-syndrome-and-its-association-with-anxiety-among-medical-students-at-king-saud-bin-abdulaziz-university-for-health-sciences-in-riyadh
#12
Meshal Khaled Alaqeel, Nasser Abdullah Alowaimer, Anas Fahad Alonezan, Nawaf Yousef Almegbel, Fahad Yousef Alaujan
OBJECTIVE: To quantify the prevalence of Irritable Bowel Syndrome (IBS) among medical students of King Saud bin Abdulaziz University for Health Sciences (KSAU-HS) and to observe the association between anxiety and IBS. METHODS: This cross-sectional observational study conducted during academic year 2015-2016 has used two self-administered, pre-validated questionnaires: Depression Anxiety Stress Scales-21 (DASS-21) and Rome III criteria. The sample size was 270, and proportional allocation was used to determine distribution of this sample across study population based on percentages of students in each academic year...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28353198/is-there-sufficient-evidence-to-support-an-optimum-time-for-the-extraction-of-first-permanent-molars
#13
REVIEW
M Wu, L Chen, E Bawole, R P Anthonappa, N M King
AIM: To evaluate whether the literature contains evidence, of an appropriate quality, to support the fundamental belief that there is an "optimal time" for extraction of FPMs with a poor prognosis. METHODS: A comprehensive search, limited to human studies, was performed using five databases. PICO based inclusion and exclusion criteria were employed to facilitate article selection. Three independent reviewers assessed the quality of included studies using STROBE and GRADE criteria...
March 28, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28335088/further-characterization-of-computed-tomographic-and-clinical-features-for-staging-and-prognosis-of-idiopathic-pulmonary-fibrosis-in-west-highland-white-terriers
#14
Florence Thierry, Ian Handel, Gawain Hammond, Lesley G King, Brendan M Corcoran, Tobias Schwarz
Idiopathic pulmonary fibrosis is an interstitial lung disease of unknown etiology resulting in progressive interstitial fibrosis, with a known predilection in West Highland white terriers. In humans, computed tomography (CT) is a standard method for providing diagnostic and prognostic information, and plays a major role in the idiopathic pulmonary fibrosis staging process. Objectives of this retrospective, analytical, cross-sectional study were to establish descriptive criteria for reporting CT findings and test correlations among CT, clinical findings and survival time in West Highland white terriers with idiopathic pulmonary fibrosis...
March 23, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28298792/comparison-of-king-vision-and-truview-laryngoscope-for-postextubation-visualization-of-vocal-cord-mobility-in-patients-undergoing-thyroid-and-major-neck-surgeries-a-randomized-clinical-trial
#15
Anto Sahaya Priyanka, Kusha Nag, V R Hemanth Kumar, Dewan Roshan Singh, Senthil Kumar, T Sivashanmugam
BACKGROUND: Visualization of vocal cords following extubation after thyroid and major neck surgeries is highly desirable for the surgeon as well as the anaesthesiologist to rule out vocal cord palsy or oedema. As the patient is emerging from general anaesthesia, it may be challenging for the anaesthesiologist to optimally visualise and grade vocal cord movement following extubation. SETTING: Randomized clinical trial at a tertiary care centre. METHODOLOGY: After obtaining institutional ethics committee approval, 60 patients posted for thyroid and major neck surgeries under American Society of Anesthesiologists (ASA) grade I and II were recruited for the study...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28292384/association-of-learning-and-memory-calcineurin-binding-protein-with-autism-spectrum-disorders
#16
Abdulrahman Mohammed Alhowikan, Laila Y. Al- ayadhi, Adel Q. Alkhedaide
OBJECTIVE: To determine the association of learning and memory calcineurin binding (CABIN1) protein with autism spectrum disorders. STUDY DESIGN: Cross-sectional comparative study. PLACE AND DURATION OF STUDY: The Autism Research and Treatment Center, King Khalid University Hospital, Riyadh, Saudi Arabia, from October 2013 to May 2014. METHODOLOGY: Serum levels of CABIN1 protein in 62 (64%) autistic male children were analysed and 35 (36%) age healthy children measured by using ELISA...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28292382/comparison-of-harmless-acute-pancreatitis-score-with-ranson-s-score-in-predicting-the-severity-of-acute-pancreatitis
#17
Hamad Hadi Al-Qahtani, Mohammed Khurshid Alam, Muhammad Waheed
OBJECTIVE: To determine the predictability of harmless acute pancreatitis score (HAPS) in determining the severity of acute pancreatitis (AP) and compare it with Ranson's score. STUDY DESIGN: Prospective cohort study. PLACE AND DURATION OF STUDY: King Saud Medical City, Riyadh, Kingdom of Saudi Arabia, between January 2012 and December 2015. METHODOLOGY: All patients admitted with AP at King Saud Medical City, Riyadh, during 2012 - 2015 were studied prospectively...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28290737/what-is-the-state-of-the-science-on-physical-activity-interventions-for-family-caregivers-a-systematic-review-and-re-aim-evaluation
#18
Colleen A Cuthbert, Kathryn King-Shier, Dean Ruether, Dianne M Tapp, S N Culos-Reed
BACKGROUND: Family caregivers are an important health care resource and represent a significant proportion of Canadian and US populations. Family caregivers suffer physical and psychological health problems because of being in the caregiver role. Interventions to support caregiver health, including physical activity (PA), are slow to be investigated and translated into practice. PURPOSE: To examine the evidence for PA interventions in caregivers and determine factors hampering the uptake of this evidence into practice...
March 14, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28286561/systematic-review-and-meta-analysis-the-effects-of-fermented-milk-with-bifidobacterium-lactis-cncm-i-2494-and-lactic-acid-bacteria-on-gastrointestinal-discomfort-in-the-general-adult-population
#19
REVIEW
Jacqui Eales, Peter Gibson, Peter Whorwell, John Kellow, Ann Yellowlees, Richard H J Perry, Mary Edwards, Sarah King, Hannah Wood, Julie Glanville
BACKGROUND: It has been suggested that probiotics may improve gastrointestinal discomfort. Not all probiotics exhibit the same effects and consequently meta-analyses on probiotics should be confined to well-defined strains or strain combinations. The aim of this study was to evaluate the effectiveness of a probiotic fermented milk (PFM) that includes Bifidobacterium lactis (B. lactis) CNCM I-2494 and lactic acid bacteria on gastrointestinal discomfort in the general adult population. METHODS: Double-blind randomized controlled trials in the general adult population comparing PFM with a control dairy product for at least 4 weeks were searched from multiple literature databases (up to February 2015)...
January 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28285275/assessment-of-junior-doctors-admission-notes-do-they-follow-what-they-learn
#20
Rashid A Barnawi, Abdulaziz M Ghurab, Hassan K Balubaid, Sultan S Alfaer, Kamal A Hanbazazah, Mohammed F Bukhari, Omayma A Hamed, Talal M Bakhsh
Objectives: To assess the completeness of history-taking and physical-examination notes of junior doctors at King Abdulaziz University Hospital per the approach they learned in medical school. Methods: In this retrospective study, we reviewed 860 admission notes written by 269 junior doctors (interns and residents) in an academic tertiary-care medical centre in Jeddah, Saudi Arabia, over a two-month period. Notes were evaluated for completeness using a checklist developed with reference to relevant medical textbooks...
March 11, 2017: International Journal of Medical Education
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