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Non-vertebral Fractures

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https://www.readbyqxmd.com/read/29649655/bone-mineral-density-changes-over-time-in-diffuse-idiopathic-skeletal-hyperostosis-of-the-thoracic-spine
#1
Jonneke S Kuperus, Lima Samsour, Constantinus F Buckens, F Cumhur Oner, Pim A de Jong, Jorrit-Jan Verlaan
Diffuse idiopathic skeletal hyperostosis (DISH) is an increasingly prevalent ankylosing condition. Patients with DISH have an increased risk of spinal fractures, hypothetically the result of biomechanical changes in the spine. The aim of this study was to analyze the occurrence of biomechanical stress shielding in patients with DISH. To do this, bone mineral density (BMD) was measured longitudinally in the vertebral bodies of subjects with and without DISH and in the newly formed bone of subjects with DISH...
April 9, 2018: Bone
https://www.readbyqxmd.com/read/29649091/the-prognostic-significance-of-pedicle-enhancement-from-contrast-enhanced-mri-for-the-further-collapse-in-osteoporotic-vertebral-compression-fractures
#2
Sung Eun Hyun, Jin Young Ko, Eugene Lee, Ju Seok Ryu
STUDY DESIGN: Retrospective observational study. OBJECTIVE: The aim of this study was to investigate the prognostic significance of contrast-enhanced MRI for detecting pedicle enhancement and predicting future collapse in patients with acute benign osteoporotic vertebral compression fracture (OVCF). SUMMARY OF BACKGROUND DATA: Traditional morphological classification regarding compression versus burst fractures cannot accurately anticipate the prognosis of further collapse...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29604509/the-role-of-the-size-and-location-of-the-tumors-and-of-the-vertebral-anatomy-in-determining-the-structural-stability-of-the-metastatically-involved-spine-a-finite-element-study
#3
Fabio Galbusera, Zhihui Qian, Gloria Casaroli, Tito Bassani, Francesco Costa, Benedikt Schlager, Hans-Joachim Wilke
Vertebral fractures associated with the loss of structural integrity of neoplastic vertebrae are common, and determined to the deterioration of the bone quality in the lesion area. The prediction of the fracture risk in metastatically involved spines can guide in deciding if preventive solutions, such as medical prophylaxis, bracing, or surgery are indicated for the patient. In this study, finite element models of 22 thoracolumbar vertebrae were built based on CT scans of three spines, covering a wide spectrum of possible clinical scenarios in terms of age, bone quality and degenerative features, taking into account the local material properties of bone tissue...
March 28, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29594122/comorbidities-in-spondyloarthritis
#4
REVIEW
Anna Moltó, Elena Nikiphorou
Comorbidities in spondyloarthritis (SpA) add to the burden of disease by contributing to disease activity, functional and work disability, and mortality. Thus, awareness of comorbidities in SpA is crucial to improve their screening and management and to ultimately improve outcomes in those affected. Osteoporosis has been reported to be the most prevalent comorbidity in SpA, and its risk is increased in these patients, compared with the general population; the risk of vertebral fractures requires further evaluation...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29565945/is-vitamin-d-supplementation-effective-for-low-back-pain-a-systematic-review-and-meta-analysis
#5
Joshua R Zadro, Debra Shirley, Manuela Ferreira, Ana Paula Carvalho Silva, Sarah E Lamb, Cyrus Cooper, Paulo H Ferreira
BACKGROUND: Low back pain (LBP) is the leading cause of years lived with disability worldwide. Current intervention strategies are failing to reduce the enormous global burden of LBP and are prompting researchers to investigate alternative management strategies, such as vitamin D supplementation. Vitamin D supplementation appears to down regulate pro-inflammatory cytokines which lead to pain and up regulate anti-inflammatory cytokines that reduce inflammation. These mechanisms might explain the increasing interest in the use of vitamin D supplementation for LBP...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29564735/real-world-effectiveness-of-osteoporosis-therapies-for-fracture-reduction-in-post-menopausal-women
#6
Akeem A Yusuf, Steven R Cummings, Nelson B Watts, Maurille Tepie Feudjo, J Michael Sprafka, Jincheng Zhou, Haifeng Guo, Akhila Balasubramanian, Cyrus Cooper
Studies examining real-world effectiveness of osteoporosis therapies are beset by limitations due to confounding by indication. By evaluating longitudinal changes in fracture incidence, we demonstrated that osteoporosis therapies are effective in reducing fracture risk in real-world practice settings. INTRODUCTION: Osteoporosis therapies have been shown to reduce incidence of vertebral and non-vertebral fractures in placebo-controlled randomized clinical trials. However, information on the real-world effectiveness of these therapies is limited...
March 21, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29564475/increased-rate-of-osteoporosis-low-lean-mass-and-fragility-fractures-in-copd-patients-association-with-disease-severity
#7
R Q Graumam, M M Pinheiro, L E Nery, C H M Castro
A very high rate of osteoporosis, fractures, and low lean mass was observed in patients with chronic obstructive pulmonary disease (COPD). Disease severity was associated with bone and muscle adverse outcomes, while age ≥ 63.5 years old, low lean mass, higher iPTH, and a T-score below - 2.5 were all associated with higher risk of fracture. INTRODUCTION: Osteoporosis is frequently neglected in patients with COPD. We aimed at evaluating the rate of osteoporosis, fractures, and low lean mass in patients with COPD...
March 21, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29556678/the-trabecular-bone-score-is-associated-with-bone-mineral-density-markers-of-bone-turnover-and-prevalent-fracture-in-patients-with-end-stage-kidney-disease
#8
J Aleksova, S Kurniawan, G J Elder
Fracture risk increases in end-stage kidney disease (ESKD), but bone mineral density (BMD) measurement is less predictive of risk than in the general population. In this study of patients with ESKD, a lower trabecular bone score (TBS), indicative of microarchitectural deterioration, was associated with higher bone turnover markers and prevalent non-vertebral fracture. INTRODUCTION: Declining renal function carries increased fracture risks, but BMD is less predictive of fracture for dialysis patients than the general population...
March 19, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29555612/the-optimal-volume-fraction-in-percutaneous-vertebroplasty-evaluated-by-pain-relief-cement-dispersion-and-cement-leakage-a-prospective-cohort-study-of-130-patients-with-painful-osteoporotic-vertebral-compression-fracture-in-the-thoracolumbar-vertebra
#9
Hai-Bo Sun, Xiao-Shan Jing, Yu-Zeng Liu, Ming Qi, Xin-Kuan Wang, Yong Hai
OBJECTIVE: Our aim was to probe the relationship among cement volume/fraction, imaging features of cement distribution, and pain relief, and then to evaluate the optimal volume during percutaneous vertebroplasty. METHODS: From January 2014 to January 2017, a total of 130 patients eligible for inclusion criteria were enrolled in this prospective cohort study. According to the different degrees of pain relief, cement leakage, and cement distribution, all patients were allocated to 2 groups...
March 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29543880/increased-risk-of-osteoporosis-in-patients-with-primary-biliary-cirrhosis
#10
Chen-Yi Liao, Chi-Hsiang Chung, Pauling Chu, Kuang-Yu Wei, Tseng-Min Feng, Fu-Huang Lin, Chang-Huei Tsao, Chia-Chao Wu, Wu-Chien Chien
BACKGROUND: We evaluated the risk of osteoporosis in patients with primary biliary cirrhosis (PBC) using a nationwide population-based dataset. METHODS: In a cohort study of 986,713 individuals, we selected 2,493 PBC patients who were aged 18 years or older and had been diagnosed with PBC, based on the International Classification of Disease (ICD-9-CM) codes 571.6, during 20002010. The control cohort comprised 9,972 randomly selected, propensity matched patients (by age, gender, and index date), without PBC...
2018: PloS One
https://www.readbyqxmd.com/read/29538240/thromboembolic-events-after-traumatic-vertebral-fractures-an-analysis-of-190-192-patients
#11
Andre M Samuel, Pablo J Diaz-Collado, Raj J Gala, Matthew L Webb, Adam M Lukasiewicz, Bryce A Basques, Daniel D Bohl, Han Jo Kim, Jonathan N Grauer
STUDY DESIGN: Retrospective cohort study OBJECTIVE.: To determine the rate of venous thromboembolism event (VTE) and risk factors for their occurrence in patients with vertebral fractures. SUMMARY OF BACKGROUND DATA: Deep vein thrombosis or pulmonary embolism (VTE) events are a significant source of potentially preventable morbidity and mortality in trauma patients. In patients with traumatic vertebral fractures, a common high-energy injury sometimes resulting in spinal cord injury, there is debate about what factors may be associated with such VTEs...
March 13, 2018: Spine
https://www.readbyqxmd.com/read/29530924/inducible-wnt16-inactivation-wnt16-regulates-cortical-bone-thickness-in-adult-mice
#12
Claes Ohlsson, Petra Henning, Karin H Nilsson, Jianyao Wu, Karin L Gustafsson, Klara Sjögren, Anna E Törnqvist, Antti Koskela, Fu-Ping Zhang, Marie K Lagerquist, Matti Poutanen, Juha Tuukkanen, Ulf H Lerner, Sofia Movérare-Skrtic
Substantial progress has been made in the therapeutic reduction of vertebral fracture risk in patients with osteoporosis, but non-vertebral fracture risk has been improved only marginally. Human genetic studies demonstrate that the WNT16 locus is a major determinant of cortical bone thickness and non-vertebral fracture risk and mouse models with life-long Wnt16 inactivation revealed that WNT16 is a key regulator of cortical thickness. These studies, however, could not exclude that the effect of Wnt16 inactivation on cortical thickness might be caused by early developmental and/or growth effects...
March 12, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29529334/bisphosphonate-drug-holiday-and-fracture-risk-a-population-based-cohort-study
#13
Annette L Adams, John L Adams, Marsha A Raebel, Beth T Tang, Jennifer L Kuntz, Vinutha Vijayadeva, Elizabeth A McGlynn, Wendolyn S Gozansky
Holidays from bisphosphonates (BPs) may help to prevent rare adverse events like atypical femoral fractures, but may be appropriate only if risk of osteoporosis-related fractures does not increase. Our objective was to compare the incidence of osteoporosis-related fractures among women who had a bisphosphonate (BP) holiday to those who continued use BPs. This retrospective cohort study, conducted within 4 Kaiser Permanente integrated health system regions, included 39,502 women aged ≥45 years with ≥3 years exposure to BP...
March 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29520608/novel-compound-heterozygous-mutations-in-serpinh1-cause-rare-autosomal-recessive-osteogenesis-imperfecta-type-x
#14
Y Song, D Zhao, X Xu, F Lv, L Li, Y Jiang, O Wang, W Xia, X Xing, M Li
We identified novel compound heterozygous mutations in SERPINH1 in a Chinese boy suffering from recurrent fractures, femoral deformities, and growth retardation, which resulted in extremely rare autosomal recessive OI type X. Long-term treatment of BPs was effective in increasing BMD Z-score, reducing fracture incidence and reshaping vertebrae compression. INTRODUCTION: Osteogenesis imperfecta (OI) is a heritable bone disorder characterized by low bone mineral density, recurrent fractures, and progressive bone deformities...
March 9, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29511368/bone-turnover-status-classification-model-and-clinical-implications
#15
Alexander Fisher, Leon Fisher, Wichat Srikusalanukul, Paul N Smith
Aim: To develop a practical model for classification bone turnover status and evaluate its clinical usefulness. Methods: Our classification of bone turnover status is based on internationally recommended biomarkers of both bone formation (N-terminal propeptide of type1 procollagen, P1NP) and bone resorption (beta C-terminal cross-linked telopeptide of type I collagen, bCTX), using the cutoffs proposed as therapeutic targets. The relationships between turnover subtypes and clinical characteristic were assessed in1223 hospitalised orthogeriatric patients (846 women, 377 men; mean age 78...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29502340/sarcopenia-and-its-clinical-correlates-in-the-general-population-the-rotterdam-study
#16
Katerina Trajanoska, Josje D Schoufour, Sirwan Kl Darweesh, Elizabeth Benz I, Carolina Medina-Gomez, Louise Jm Alfernik, Lies Lahousse, Guy Brusselle, Bruno Stricker, Sarwa Darwish Murad, M Carola Zillikens, Andre G Uitterlinden, M Arfan Ikram, Oscar H Franco, Fernando Rivadeneira
Sarcopenia, a complex multifactorial condition, is characterized by loss of muscle mass and function, which increases progressively with age. The existence of different definitions has contributed to the large variation in the prevalence estimates of sarcopenia. We aimed to estimate the prevalence of sarcopenia in the general population using the European Working Group on Sarcopenia in Older People (EWGSOP) proposed definition and compared baseline demographic and clinical characteristics between the non-sarcopenia, pre-sarcopenia, and sarcopenia individuals, with particular emphasis on the overlap with osteoporosis and fracture risk...
March 4, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29480629/immunomodulatory-effect-of-vitamin-k2-implications-for-bone-health
#17
V D Myneni, E Mezey
OBJECTIVE: In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non-vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T-cell suppression by vitamin K2. MATERIALS AND METHODS: Peripheral blood mononuclear cells (PBMCs) from three healthy donors were used...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29477645/marrow-adiposity-and-bone-review-of-clinical-implications
#18
Julien Paccou, Guillaume Penel, Christophe Chauveau, Bernard Cortet, Pierre Hardouin
There is growing interest in the relationship between bone marrow fat (BMF) and skeletal health. Progress in clinical studies of BMF and skeletal health has been greatly enhanced by recent technical advances in our ability to measure BMF non-invasively. Magnetic resonance imagery (MRI) with or without spectroscopy is currently the standard technique for evaluating BMF content and composition in humans. This review focuses on clinical studies of marrow fat and its relationship with bone. The amount of marrow fat is associated with bone mineral density (BMD)...
February 27, 2018: Bone
https://www.readbyqxmd.com/read/29474508/association-between-pain-and-the-frailty-phenotype-in-older-men-longitudinal-results-from-the-concord-health-and-ageing-in-men-project-champ
#19
Rodrigo Z Megale, Manuela L Ferreira, Paulo H Ferreira, Vasi Naganathan, Robert Cumming, Vasant Hirani, Louise M Waite, Markus J Seibel, David G Le Couteur, David J Handelsman, Fiona M Blyth
Objectives: to determine whether pain increases the risk of developing the frailty phenotype and whether frailty increases the risk of developing chronic or intrusive pain, using longitudinal data. Design/Setting: longitudinal data from the Concord Health and Ageing in Men Project (CHAMP), a prospective population based cohort study. Participants: a total of 1,705 men aged 70 years or older, living in an urban area of New South Wales, Australia...
February 21, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29464371/risk-factor-analysis-for-re-collapse-of-cemented-vertebrae-after-percutaneous-vertebroplasty-pvp-or-percutaneous-kyphoplasty-pkp
#20
Yong-Xian Li, Dan-Qing Guo, Shun-Cong Zhang, De Liang, Kai Yuan, Guo-Ye Mo, Da-Xing Li, Hui-Zhi Guo, Yongchao Tang, Pei-Jie Luo
PURPOSE: Re-collapse of cemented vertebrae occasionally occurs after percutaneous augmentation. However, the potential risks still remain unclear. Several articles have reported some possible risk factors which were not consistent or comprehensive. This study aimed to make a retrospective review on patients with osteoporotic vertebral compression fracture (OVCF) after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) and to further analyse the risk factors for treated vertebral refracture...
February 20, 2018: International Orthopaedics
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