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Non-vertebral Fractures

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https://www.readbyqxmd.com/read/28093431/which-is-best-for-osteoporotic-vertebral-compression-fractures-balloon-kyphoplasty-percutaneous-vertebroplasty-or-non-surgical-treatment-a-study-protocol-for-a-bayesian-network-meta-analysis
#1
Shun-Li Kan, Zhi-Fang Yuan, Ling-Xiao Chen, Jing-Cheng Sun, Guang-Zhi Ning, Shi-Qing Feng
INTRODUCTION: Osteoporotic vertebral compression fractures (OVCFs) commonly cause both acute and chronic back pain, substantial spinal deformity, functional disability and decreased quality of life and increase the risk of future vertebral fractures and mortality. Percutaneous vertebroplasty (PVP), balloon kyphoplasty (BK) and non-surgical treatment (NST) are mostly used for the treatment of OVCFs. However, which treatment is preferred is unknown. The purpose of this study is to comprehensively review the literature and ascertain the relative efficacy and safety of BK, PVP and NST for patients with OVCFs using a Bayesian network meta-analysis...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28072794/does-percutaneous-vertebroplasty-or-balloon-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-increase-the-incidence-of-new-vertebral-fractures-a-meta-analysis
#2
Hui Zhang, Caiyuan Xu, Tongxing Zhang, Zhongyu Gao, Tao Zhang
BACKGROUND: Because of an aging population,osteoporotic vertebral fractures are becoming more frequent.Conservative therapy was considered the gold standard for treating osteoporotic vertebral compression fractures (OVCFs) in the past. Percutaneous vertebroplasty (PVP) or balloon kyphoplasty (BKP) as minimally invasive techniques are new treatments that are widely used for painful OVCFs. However, an increase in new vertebral compression fractures at non-treated levels following augmentation is of concern...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28067882/skeletal-outcome-in-long-term-survivors-of-childhood-high-risk-neuroblastoma-treated-with-high-dose-therapy-and-autologous-stem-cell-rescue
#3
P Utriainen, A Vatanen, S Toiviainen-Salo, U Saarinen-Pihkala, O Mäkitie, K Jahnukainen
High-dose therapy and hematopoietic stem cell transplantation (HSCT) have been shown to improve survival rates in high-risk neuroblastoma (HR-NBL), but may cause adverse effects on the growing skeleton. We studied skeletal health in a national cohort of long-term survivors of HR-NBL (n=21; age 16-30 years, median 22 years) and in 20 healthy age- and sex-matched controls. In addition to clinical evaluation and measurement of bone mineral density (BMD) by dual-energy X-ray absorptiometry, we performed spinal magnetic resonance imaging...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28065376/dual-energy-ct-virtual-non-calcium-technique-for-detection-of-bone-marrow-edema-in-patients-with-vertebral-fractures-a-prospective-feasibility-study-on-a-single-source-volume-ct-scanner
#4
T Diekhoff, K G Hermann, M Pumberger, B Hamm, M Putzier, M Fuchs
OBJECTIVES: Dual-energy computed tomography (DECT) is a recent development for detecting bone marrow edema (BME) in patients with vertebral compression fractures. The aim of this pilot study was to determine the reliability of single-source DECT in detecting vertebral BME using magnetic resonance imaging (MRI) as standard of reference. MATERIALS AND METHODS: Nine patients with radiographic thoracic or lumbar vertebral compression fractures underwent both, DECT on a 320-row single-source scanner and 1...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28058531/developmental-charts-for-children-with-osteogenesis-imperfecta-type-i-body-height-body-weight-and-bmi
#5
Krzysztof Graff, Malgorzata Syczewska
: Osteogenesis imperfecta (OI) is a rare genetic disorder of type I collagen. Type I is the most common, which is called a non-deforming type of OI, as in this condition, there are no major bone deformities. This type is characterised by blue sclera and vertebral fractures, leading to mild scoliosis. The body height of these patients is regarded as normal, or only slightly reduced, but there are no data proving this in the literature. The aim of this study is the preparation of the developmental charts of children with OI type I...
January 5, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28028633/real-world-evidence-of-raloxifene-versus-alendronate-in-preventing-non-vertebral-fractures-in-japanese-women-with-osteoporosis-retrospective-analysis-of-a-hospital-claims-database
#6
Sakae Tanaka, Takanori Yamamoto, Eisei Oda, Masaki Nakamura, Saeko Fujiwara
We conducted a retrospective cohort study using a de-identified hospital administrative claims database to assess the risk of non-vertebral fracture in Japanese women with osteoporosis treated with raloxifene compared with alendronate. The study included Japanese women ≥50 years of age with newly initiated alendronate or raloxifene treatment between July 2008 and March 2013 (index date was defined as the day of first prescription for alendronate or raloxifene), and had any claim with an osteoporosis definition during the study period...
December 27, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27998716/dxa-30years-and-counting-introduction-to-the-30th-anniversary-issue
#7
E Michael Lewiecki, Neil Binkley
Dual-energy X-ray absorptiometry (DXA) has a colorful history of development and evolution over the past 30years, from early predecessors that were cumbersome and limited in their clinical applications to current elegant instruments with a wide range of uses. DXA is used to diagnose osteoporosis, assess fracture risk, and monitor changes in bone mineral density (BMD). Non-BMD applications include vertebral fracture assessment, measurement of hip geometry, measurement of whole body tissue mass (i.e., bone, fat, and lean mass), abdominal aortic calcification detection and trabecular bone score measurement...
December 17, 2016: Bone
https://www.readbyqxmd.com/read/27996218/association-of-early-physical-activity-time-with-pain-activities-of-daily-living-and-progression-of-vertebral-body-collapse-in-patients-with-vertebral-compression-fractures-an-observational-study-at-single-institution
#8
Hideki Kataoka, Tatsunori Ikemoto, Ayana Yoshimura, Mihoko Shibuya, Kyo Goto, Jyunichirou Yamashita, Kaoru Morita, Jyunya Sakamoto, Jiro Nakano, Minoru Okita
BACKGROUND: Physical activity can reduce pain and improve the ability to perform daily activities in patients with acute low back pain (LBP) due to various non-specific causes. The association between physical activity during the early phase of acute vertebral compression fractures (VCFs) and rehabilitation outcomes is unknown. AIM: To investigate the effects of early physical activity time (EPAT) on pain following acute VCFs, recovery of the ability to perform activities of daily living (ADLs), and progression of fractured vertebral body collapse...
December 19, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27975350/diagnosis-of-neuropathic-components-in-patients-with-back-pain-before-and-after-surgery
#9
Y-J Lee, E M W Koch, J B Breidebach, R Bornemann, D C Wirtz, R Pflugmacher
Background: The perception of back pain subjective is hard for physicians to measure. For this reason, questionnaires are an important instrument to evaluate the pain 1. The main point of this study was to verify differentiation of pain symptoms in patients with different pain mechanisms. The most important parameter was the PainDetect questionnaire, which can differentiate between nociceptive and neuropathic pain. Additional parameters were measured before and after surgery to characterise pain symptoms in detail...
December 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27972982/economic-study-of-non-pharmacological-and-pharmacological-treatment-for-osteoporosis-vertebral-fracture-and-bone-events-in-oncology-patients-in-a-health-insurance-provider-in-a-latin-america-country
#10
E Tanaka, A Itria, F Tanaka, M Barbosa, E M Massuda, C Favoreto, W Huang, R Kuabara, C Saldanha, A C Tolentino
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27965945/replication-of-caucasian-loci-associated-with-osteoporosis-related-traits-in-east-asians
#11
Beom-Jun Kim, Seong Hee Ahn, Hyeon-Mok Kim, Shiro Ikegawa, Tie-Lin Yang, Yan Guo, Hong-Wen Deng, Jung-Min Koh, Seung Hun Lee
BACKGROUND: Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis. METHODS: A total of 95 SNPs, identified at the discovery stage of the largest GWAS meta-analysis of BMD, were tested to determine associations with osteoporosis-related traits (BMD, osteoporosis, or fracture) in Korean subjects (n=1,269)...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27924499/pedicle-screw-fixation-with-kyphoplasty-decreases-the-fracture-risk-of-the-treated-and-adjacent-non-treated-vertebral-bodies-a-finite-element-analysis
#12
Pan Yang, Ying Zhang, Huan-Wen Ding, Jian Liu, Lin-Qiang Ye, Jin Xiao, Qiang Tu, Tao Yang, Fei Wang, Guo-Gang Sun
Adjacent vertebral fractures are common in patients with osteoporotic vertebral compression fractures (OVCFs) after kyphoplasty. This finite element study was to examine whether short segment pedicle screw fixation (PSF) with kyphoplasty may decrease the fracture risk of the treated and adjacent non-treated vertebrae after kyphoplasty for OVCFs. By simulating cement augmentation with or without short segment pedicle screw fixation (PSF), two tridimensional, anatomically detailed finite element models of the T10-L2 functional spinal junction were developed...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27915335/network-meta-analysis-of-pharmacological-agents-for-osteoporosis-treatment-and-fracture-prevention
#13
Xu-Cheng Yang, Zhen-Han Deng, Ting Wen, Wei Luo, Wen-Feng Xiao, Rui-Bo Zhao, Yu-Sheng Li
BACKGROUND AND OBJECTIVE: Osteoporosis afflicts a large number of populations in the world and is featured by systemic impairment of bone mass and strength which may further trigger an increase in the risk of fragile fractures. This network meta-analysis (NMA) is designed to distinguish therapies more preferable than others with respect to efficacy and safety. METHODS: We searched the medical literature for relevant studies systematically. Both direct and indirect evidence were synthesized to compare the efficacy, described by odds ratios (OR) and 95% credible intervals (CrI)...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27906947/a-longitudinal-cohort-investigation-of-the-development-of-symptomatic-adjacent-level-compression-fractures-following-balloon-assisted-kyphoplasty-in-a-series-of-726-patients
#14
Christopher P Deibert, Gurpreet S Gandhoke, Erin E Paschel, Peter C Gerszten
BACKGROUND: Balloon-assisted kyphoplasty (BAK) is a well-accepted treatment for symptomatic vertebral compression fractures (VCF) secondary to osteoporosis. Some have raised a concern of an increased incidence of adjacent fractures due to alterations in spine biomechanics after cement augmentation. The incidence of subsequent VCFs following BAK is poorly understood. The aim of this study was to investigate the timing, location, and incidence of new VCFs following BAK and to identify risk factors associated specifically with the occurrence of new adjacent level fractures...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27900428/relationship-between-baseline-characteristics-and-response-to-risedronate-treatment-for-osteoporosis-data-from-three-japanese-phase-iii-trials
#15
T Mawatari, R Muraoka, Y Iwamoto
: We evaluated the influence of baseline age, bone mineral density (BMD), and serum levels of vitamin D on the response to risedronate treatment. Risedronate consistently increased BMD, but our results suggest vitamin D supplementation may be necessary to achieve optimal treatment effect. Furthermore, early intervention may help prevent bone fractures. INTRODUCTION: We aimed to investigate the influence of baseline age, BMD, and vitamin D insufficiency on the response to risedronate treatment...
November 30, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27890439/a-japanese-nationwide-multicenter-survey-on-perioperative-complications-of-corrective-fusion-for-elderly-patients-with-adult-spinal-deformity
#16
Yu Yamato, Yukihiro Matsuyama, Kazuhiro Hasegawa, Yoichi Aota, Tsutomu Akazawa, Takahiro Iida, Kazumasa Ueyama, Koki Uno, Tokumi Kanemura, Noriaki Kawakami, Toshiaki Kotani, Masashi Takaso, Jun Takahashi, Masato Tanaka, Hiroshi Taneichi, Taichi Tsuji, Hideo Hosoe, Joji Mochida, Takachika Shimizu, Ikuho Yonezawa, Kota Watanabe, Morio Matsumoto
BACKGROUND: Recently, corrective fusion surgery for patients with adult spinal deformity (ASD) has become common in Japan. This study aimed to clarify the status of surgeries for ASD in Japan, focusing on perioperative complications. A nationwide multicenter survey gathering information on surgically treated ASD patients was conducted by the committee for Adult Spinal Deformity of the Japanese Scoliosis Society. METHODS: This study was a review of retrospectively collected data from 18 spine scoliosis centers belonging to the Japanese Scoliosis Society...
November 24, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27871806/does-vertebral-augmentation-lead-to-an-increasing-incidence-of-adjacent-vertebral-failure-a-systematic-review-and-meta-analysis
#17
REVIEW
Baoyou Fan, Zhijian Wei, Xianhu Zhou, Wei Lin, Yiming Ren, Ang Li, Guidong Shi, Yan Hao, Shen Liu, Hengxing Zhou, Shiqing Feng
BACKGROUND: The aim of the present study was to evaluate whether vertebral augmentation technology increases the occurrence of adjacent vertebral fractures in patients with osteoporotic vertebral compression fractures (OVCFs). MATERIALS AND METHODS: Databases, including MEDLINE, EMBASE and Cochrane library, were retrieved via PRISMA covering 1987 to 2015. The number of patients who suffered from adjacent secondary vertebral fractures was calculated. A meta-analysis, using indexes of odds ratios (OR) and 95% confidence intervals (95% CI), was conducted with STATA software...
December 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27845263/osteoclastogenic-capacity-of-peripheral-blood-mononuclear-cells-is-not-different-between-women-with-and-without-osteoporosis
#18
W N H Koek, B C J van der Eerden, R D A M Alves, M van Driel, M Schreuders-Koedam, M C Zillikens, J P T M van Leeuwen
INTRODUCTION: Peripheral Blood Mononuclear Cells (PBMCs) have been extensively used as a culture model to generate osteoclasts in vitro. The aim of this study was to assess the osteoclastogenic potential of PBMCs derived from post-menopausal women with longstanding osteoporosis and compare this with PBMCs from healthy controls. MATERIAL AND METHODS: We selected from the population-based Rotterdam Study 82 participants of which 43 were diagnosed with osteoporosis (T-score below -2...
November 12, 2016: Bone
https://www.readbyqxmd.com/read/27833676/variation-of-blunt-traumatic-injury-with-age-in-older-adults-statewide-analysis-2011-14
#19
Emily Earl-Royal, Frances Shofer, Dominique Ruggieri, Rosemary Frasso, Daniel Holena
INTRODUCTION: Traumatic injury is a leading cause of death and disability in adults ≥ 65 years old, but there are few epidemiological studies addressing this issue. The aim of this study was to assess how characteristics of blunt traumatic injuries in adults ≥ 65 vary by age. METHODS: Using data from the a single-state trauma registry, this retrospective cohort study examined injured patients ≥ 65 admitted to all Level I and Level II trauma centers in Pennsylvania between 2011 and 2014 (n=38,562)...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27831489/increased-sagittal-vertical-axis-is-associated-with-less-effective-control-of-acute-pain-following-vertebroplasty
#20
Y-C Kim, D H Bok, H-G Chang, S W Kim, M S Park, J K Oh, J Kim, T-H Kim
OBJECTIVES: Although vertebroplasty is very effective for relieving acute pain from an osteoporotic vertebral compression fracture, not all patients who undergo vertebroplasty receive the same degree of benefit from the procedure. In order to identify the ideal candidate for vertebroplasty, pre-operative prognostic demographic or clinico-radiological factors need to be identified. The objective of this study was to identify the pre-operative prognostic factors related to the effect of vertebroplasty on acute pain control using a cohort of surgically and non-surgically managed patients...
November 2016: Bone & Joint Research
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