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Non-vertebral Fractures

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https://www.readbyqxmd.com/read/28213865/location-of-vertebral-fractures-is-associated-with-bone-mineral-density-and-history-of-traumatic-injury
#1
Jennifer Watt, Richard Crilly
The upper and lower thoracolumbar spine have been associated with different biomechanical outcomes. This concept, as it applies to osteoporotic fracture risk, has not been well documented. This was a case-control study of 120 patients seen in an osteoporosis clinic. Vertebral fractures were identified from lateral radiographs using Genant's semi-quantitative assessment method. An association between bone mineral density (BMD) T-scores and vertebral fracture location was assessed. In an additional analysis, the association between a history of any traumatic injury and possible predictor variables was also explored...
February 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28210776/cost-effectiveness-of-denosumab-versus-oral-alendronate-for-elderly-osteoporotic-women-in-japan
#2
T Mori, C J Crandall, D A Ganz
: We constructed a Markov microsimulation model among hypothetical cohorts of community-dwelling elderly osteoporotic Japanese women without prior hip or vertebral fractures over a lifetime horizon. Compared with weekly oral alendronate for 5 years, denosumab every 6 months for 5 years is cost-saving or cost-effective at a conventionally accepted threshold. INTRODUCTION: The objective of the study was to examine the cost-effectiveness of subcutaneous denosumab every 6 months for 5 years compared with weekly oral alendronate for 5 years in Japan...
February 17, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28210775/risk-of-fragility-fracture-among-patients-with-sarcoidosis-a-population-based-study-1976-2013
#3
P Ungprasert, C S Crowson, E L Matteson
: Incidence of fragility fracture of a population-based cohort of 345 patients with sarcoidosis was compared with age and sex-matched comparators. The incidence of fragility fracture was higher among patients with sarcoidosis with hazard ratio (HR) of 2.18. INTRODUCTION: Several chronic inflammatory disorders increase the risk of fragility fracture. However, little is known about the risk of fragility fracture in patients with sarcoidosis. METHODS: This study was conducted using a previously identified population-based cohort of 345 patients with incident sarcoidosis from Olmsted County, Minnesota...
February 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28197890/relationships-among-diet-physical-activity-and-dual-plane-dual-energy-x-ray-absorptiometry-bone-outcomes-in-pre-pubertalgirls
#4
Jie Ren, Lynn S Brann, Kay S Bruening, Tamara A Scerpella, Jodi N Dowthwaite
: In pre-pubertal girls, nutrient intakes and non-aquatic organized activity were evaluated as factors in vertebral body bone mass, structure, and strength. Activity, vitamin B12, and dietary fiber predicted bone outcomes most consistently. Exercise and vitamin B12 appear beneficial, whereas high fiber intake appears to be adverse for vertebral body development. PURPOSE: Childhood development sets the baseline for adult fracture risk. Most studies evaluate development using postero-anterior (PA) dual-energy X-ray absorptiometry (DXA) areal bone mineral density, bone mineral content, and bone mineral apparent density...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28186942/use-of-combination-therapy-in-the-treatment-of-primary-osteoporosis-protocol-for-a-network-meta-analysis-of-randomised-trials
#5
Shenghan Lou, Houchen Lv, Yuxiang Chen, Licheng Zhang, Peifu Tang
INTRODUCTION: The existing medications approved for treatment of primary osteoporosis can be divided into antiresorptive drugs and anabolic drugs. According to the mechanisms of action, the combined therapy may produce a synergistic effect on bone mineral density (BMD) compared with monotherapy, and thus improves the efficacy of fracture resistance. This network meta-analysis aims to compare the efficacies of different combined methods for the treatment of primary osteoporosis. METHODS AND ANALYSIS: MEDLINE, EMBASE and Cochrane databases will be searched to identify all randomised controlled trials (RCTs) and quasi-RCTs that evaluate the effectiveness of combined therapy versus monotherapy for primary osteoporosis...
November 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/28179169/vertebral-bone-marrow-fat-bone-mineral-density-and-diabetes-the-osteoporotic-fractures-in-men-mros-study
#6
Yahtyng Sheu, Francesca Amati, Ann V Schwartz, Michelle E Danielson, Xiaojuan Li, Robert Boudreau, Jane A Cauley
Elevated vertebral bone marrow fat (BMF) among individuals with osteoporosis has been established in histomorphometric studies. Several studies have found a negative correlation between BMF and bone mineral density (BMD) at the spine in men and women across different age groups. Animal studies have also observed bone loss with increased BMF in mice with induced diabetes. Our study objective was to test the hypothesis that the association between BMF and BMD varies by diabetic status. We performed a cross-sectional study of 156 men aged 74-96years from the Osteoporotic Fractures in Men study at the Pittsburgh clinical site...
February 4, 2017: Bone
https://www.readbyqxmd.com/read/28175980/spine-fracture-prevalence-in-a-nationally-representative-sample-of-us-women-and-men-aged-%C3%A2-40-years-results-from-the-national-health-and-nutrition-examination-survey-nhanes-2013-2014
#7
F Cosman, J H Krege, A C Looker, J T Schousboe, B Fan, N Sarafrazi Isfahani, J A Shepherd, K D Krohn, P Steiger, K E Wilson, H K Genant
: Spine fracture prevalence is similar in men and women, increasing from <5 % in those <60 to 11 % in those 70-79 and 18 % in those ≥80 years. Prevalence was higher with age, lower bone mineral density (BMD), and in those meeting criteria for spine imaging. Most subjects with spine fractures were unaware of them. INTRODUCTION: Spine fractures have substantial medical significance but are seldom recognized. This study collected contemporary nationally representative spine fracture prevalence data...
February 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28173850/new-horizons-in-treatment-of-osteoporosis
#8
REVIEW
Ozra Tabatabaei-Malazy, Pooneh Salari, Patricia Khashayar, Bagher Larijani
BACKGROUND: Prevalence of osteoporosis is increasing both in developed and developing countries. Due to rapid growth in the burden and cost of osteoporosis, worldwide, it seems reasonable to focus on the reduction of fractures as the main goal of treatment. Although, efficient pharmacological agents are available for the treatment of osteoporosis, there still remains a need to more specific drugs with less adverse effects. MAIN BODY: This review article provides a brief update on the pathogenesis, presenting current pharmacological products approved by the US Food and Drug Administration (FDA) or Europe, and also newer therapeutic agents to treat osteoporosis according to the clinical trial data available at PubMed, UpToDate, International Osteoporosis Foundation (IOF), and clinical practice guidelines...
February 7, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28169041/treatment-of-postmenopausal-osteoporosis-a-literature-based-algorithm-for-use-in-the-public-health-care-system
#9
Ellen Luz Pereira Caires, Mailze Campos Bezerra, Ana Flávia Torquato de Araújo Junqueira, Sheila Márcia de Araújo Fontenele, Silvana Cristina de Albuquerque Andrade, Catarina Brasil d'Alva
Bisphosphonates are considered first-line agents in the treatment of postmenopausal osteoporosis based on extensive experience of use, safety, and proven efficacy in reducing vertebral, non-vertebral and femur fractures. However, post-marketing reports based on the treatment of millions of patients/year over lengthy periods of time have revealed the occurrence of initially unexpected adverse effects, such as osteonecrosis of the jaw and atypical femoral fracture, leading to the restriction of treatment duration with bisphosphonates by global regulatory agencies...
December 27, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28167249/how-are-adjacent-spinal-levels-affected-by-vertebral-fracture-and-by-vertebroplasty-a-biomechanical-study-on-cadaveric-spines
#10
Jin Luo, Deborah J Annesley-Williams, Michael A Adams, Patricia Dolan
BACKGROUND CONTEXT: Spinal injuries and surgery may have important effects at neighbouring spinal levels, but previous investigations of adjacent-level biomechanics have produced conflicting results. We use 'stress profilometry' and non-contact strain measurements to investigate thoroughly this long-standing problem. PURPOSE: To determine how vertebral fracture and vertebroplasty affect compressive load-sharing and vertebral deformations at adjacent spinal levels...
February 3, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28163861/cost-effectiveness-of-zoledronic-acid-to-prevent-and-treat-postmenopausal-osteoporosis-in-comparison-with-routine-medical-treatment
#11
Fateme Rostami Golmohamdi, Mahnaz Abbasi, Ali Kazemi Karyani, Ali Akbari Sari
INTRODUCTION: Fractures caused by osteoporosis are prevalent among elderly females, which reduce quality of life significantly. This study aimed at comparing cost-effectiveness of Zoledronic acid in preventing and treating post-menopause osteoporosis as compared with routine medical treatment. METHODS: This cost-effectiveness study was carried out retrospectively from the Ministry of Health and insurance organizations perspective. Costs were evaluated based on the cost estimation of a sample of patients...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28161589/women-with-type-2-diabetes-mellitus-have-lower-cortical-porosity-of-the-proximal-femoral-shaft-using-low-resolution-ct-than-nondiabetic-women-and-increasing-glucose-is-associated-with-reduced-cortical-porosity
#12
Marit Osima, Rita Kral, Tove T Borgen, Ingvild K Høgestøl, Ragnar M Joakimsen, Erik F Eriksen, Åshild Bjørnerem
Increased cortical porosity has been suggested as a possible factor increasing fracture propensity in patients with type 2 diabetes mellitus (T2DM). This is a paradox because cortical porosity is generally associated with high bone turnover, while bone turnover is reduced in patients with T2DM. We therefore wanted to test the hypothesis that women with T2DM have lower bone turnover markers (BTM) and lower cortical porosity than those without diabetes, and that higher serum glucose and body mass index (BMI) are associated with lower BTM, and with lower cortical porosity...
February 1, 2017: Bone
https://www.readbyqxmd.com/read/28160398/failed-percutaneous-vertebroplasty-due-to-insufficient-correction-of-intravertebral-instability-in-kummell-s-disease-a-case-report
#13
Jung Eun Kim, Sang Sik Choi, Mi Kyoung Lee, Dong Kyu Lee, Seung Inn Cho
Kummell's disease, caused by osteonecrosis of the vertebral body, is a cause of vertebral collapse. In Kummell's disease, intravertebral instability from non-union between the cement and bone after percutaneous vertebroplasty (PVP) can cause persistent severe pain and dysfunction. A 75-year-old woman presented with severe pain in the lower back, both buttocks, groin, and both posterior thighs for a period of 30 days. Lumbar radiographs and magnetic resonance images showed an acute compression fracture of the first lumbar vertebra with an intravertebral cleft filled with fluid...
February 3, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28154269/decreased-serum-insulin-like-growth-factor-i-is-a-risk-factor-for-non-vertebral-fractures-in-diabetic-postmenopausal-women
#14
Hitomi Miyake, Ippei Kanazawa, Toshitsugu Sugimoto
Objective Previous studies have shown that serum insulin-like growth factor-I (IGF-I) is involved in diabetes-related bone fragility. Although lower serum levels of IGF-I are reported to be associated with a higher risk of vertebral fractures in patients with type 2 diabetes, it is unknown whether or not the serum level of IGF-I is associated with the incidence of non-vertebral fractures. Methods We investigated the relationships between the serum levels of IGF-I and the incidence of non-vertebral osteoporotic fractures in 188 men and 168 postmenopausal women with type 2 diabetes...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28149529/prophylactic-vertebroplasty-procedure-applied-with-a-resorbable-bone-cement-can-decrease-the-fracture-risk-of-sandwich-vertebrae-long-term-evaluation-of-clinical-outcomes
#15
Pu Jia, Hai Tang, Hao Chen, Li Bao, Fei Feng, He Yang, Jinjun Li
A sandwich vertebra is formed after multiple osteoporotic vertebral fractures treated by percutaneous vertebroplasty, which has a risk of developing new fractures. The purpose of our study was to (i) investigate the occurrence of new fractures in sandwich vertebra after cement augmentation procedures and to (ii) evaluate the clinical outcomes after prophylactic vertebral reinforcement applied with resorbable bone cement. From June 2011 to 2014, we analysed 55 patients with at least one sandwich vertebrae and treated with percutaneous vertebroplasty...
February 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28138718/preceding-and-subsequent-high-and-low-trauma-fracture-patterns-a-13-year-epidemiological-study-in-females-and-males-in-austria
#16
C Muschitz, R Kocijan, A Baierl, R Dormann, X Feichtinger, J Haschka, M Szivak, G K Muschitz, J Schanda, P Pietschmann, H Resch, H P Dimai
: This study investigated the implication of a preceding high-trauma fracture on subsequent high- and low-trauma fractures at different skeletal sites in postmenopausal women and similarly aged men at an age range of 54 to 70 years. A preceding high-trauma fracture increases the risk of future low-trauma non-vertebral fractures including hip. INTRODUCTION: Little is known about the impact of the skeletal fracture site in conjunction with the severity of a past fracture (high- or low-trauma preceding fracture) and its effect on future fracture risk...
January 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28123128/-effects-of-zoledronic-acid-on-osteoporosis-patients-in-japan
#17
Sakae Tanaka
Zoledronic acid is a bisphosphonate with the most potent anti-bone resorbing activity. Several previous studies demonstrated that zoledronic acid once a year significantly reduced the risk of vertebral, non-vertebral, and hip fractures in postmenopausal women. In a phase Ⅲ 2-year placebo-controlled, randomized, double-blind comparative study in Japan(ZONE study)demonstrated that once-yearly infusion of zoledronic acid 5 mg increased lumbar spine and proximal femoral BMD, and reduced the incidence of vertebral and non-vertebral fractures in Japanese patients with primary osteoporosis compared to placebo...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28120055/restoration-of-thoracolumbar-spine-stability-and-alignment-in-elderly-patients-using-minimally-invasive-spine-surgery-miss-a-safe-and-feasible-option-in-degenerative-and-traumatic-spine-diseases
#18
Giuseppe M V Barbagallo, Giuseppe Raudino, Massimiliano Visocchi, A Abdulrazzaq Alobaid, A Abdulaziz Al-Mutair, Thomas Naveen, Francesco Certo
Minimally invasive spine surgery (MISS), including percutaneous pedicle-screw fixation (PPSF), mini-open transforaminal lumbar interbody fusion (m-open TLIF), vertebroplasty, and stentoplasty, allows the preservation of neurological function and the restoration of spine stability, while reducing associated risks and complications. This study aimed to analyze the safety and efficacy of MISS in elderly patients suffering from degenerative or traumatic thoracolumbar diseases. Forty-five patients (28 females), with a mean age of 73 years (range 65-89), suffering from osteoporotic vertebral fractures (24), degenerative spondylolisthesis (15), and lumbar canal stenosis with instability and/or de novo scoliosis (6) were included...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28117876/interventions-to-prevent-and-treat-corticosteroid-induced-osteoporosis-and-prevent-osteoporotic-fractures-in-duchenne-muscular-dystrophy
#19
REVIEW
Jennifer M Bell, Michael D Shields, Janet Watters, Alistair Hamilton, Timothy Beringer, Mark Elliott, Rosaline Quinlivan, Sandya Tirupathi, Bronagh Blackwood
BACKGROUND: Corticosteroid treatment is considered the 'gold standard' for Duchenne muscular dystrophy (DMD); however, it is also known to induce osteoporosis and thus increase the risk of vertebral fragility fractures. Good practice in the care of those with DMD requires prevention of these adverse effects. Treatments to increase bone mineral density include bisphosphonates and vitamin D and calcium supplements, and in adolescents with pubertal delay, testosterone. Bone health management is an important part of lifelong care for patients with DMD...
January 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28116510/teriparatide-versus-low-dose-bisphosphonates-before-and-after-surgery-for-adult-spinal-deformity-in-female-japanese-patients-with-osteoporosis
#20
Shoji Seki, Norikazu Hirano, Yoshiharu Kawaguchi, Masato Nakano, Taketoshi Yasuda, Kayo Suzuki, Kenta Watanabe, Hiroto Makino, Masahiko Kanamori, Tomoatsu Kimura
PURPOSE: Complications of adult spinal deformity surgery are problematic in osteoporotic individuals. We compared outcomes between Japanese patients treated perioperatively with teriparatide vs. low-dose bisphosphonates. METHODS: Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion. Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age...
January 23, 2017: European Spine Journal
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