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Clinical Densitometry

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https://www.readbyqxmd.com/read/29931734/evaluation-of-corneal-and-lens-clarity-in-unilateral-pseudoexfoliation-syndrome-a-densitometric-analysis
#1
Irfan Durukan
BACKGROUND: Although ageing is the main reason for cataract progression, pseudoexfoliation syndrome (PES) represents an independent additional hazard for the development of nuclear sclerosis and cataract progression. PES can also affect corneal properties. From this perspective, this study aimed to perform a comparison of the corneal and lens densitometry measurements in eyes with PES and age-matched healthy eyes. METHODS: This prospective cross-sectional study included 31 patients with unilateral PES and 40 control participants...
June 21, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29920949/evaluation-of-a-new-commercial-method-for-von-willebrand-factor-multimeric-analysis
#2
R A Crist, N M Heikal, G M Rodgers, D G Grenache, K J Smock
INTRODUCTION: Evaluation of von Willebrand factor (VWF) multimeric distribution is useful for subclassification of von Willebrand disease (VWD). Multimer analysis has historically been a manual, labor-intensive laboratory-developed test. The first commercial method for multimeric analysis was recently developed that utilizes a single instrument for gel electrophoresis, staining, and densitometry. The current study was undertaken to evaluate the performance characteristics of the new commercial method...
June 19, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29903644/high-parathyroid-hormone-levels-are-associated-with-osteosarcopenia-in-older-individuals-with-a-history-of-falling
#3
Pushpa Suriyaarachchi, Fernando Gomez, Carmen L Curcio, Derek Boersma, Lavanya Murthy, Vivian Grill, Gustavo Duque
OBJECTIVES: The combination of osteopenia/osteoporosis and sarcopenia (osteosarcopenia) defines a diagnostic subset of individuals at higher risk of falls, fractures and institutionalization. In this study we aimed to assess the potential role of high serum levels of parathyroid hormone (PTH) in osteosarcopenia. We hypothesized that a high PTH level is one of the major determinants of this syndrome. STUDY DESIGN: Cross-sectional study in 400 subjects (mean age = 79, 65% women) assessed between 2009 and 2014 at the Falls and Fractures Clinic, Nepean Hospital (Penrith, Australia)...
July 2018: Maturitas
https://www.readbyqxmd.com/read/29861269/host-cell-protein-testing-strategy-for-hepatitis-b-antigen-in-hexavalent-vaccine-towards-a-general-testing-strategy-for-recombinant-vaccines
#4
Audrey Toinon, Christelle Fontaine, Laurent Thion, Beata Gajewska, Bruce Carpick, Nolwenn Nougarede, Sylvie Uhlrich
BACKGROUND: Recombinant proteins expressed in host cell systems may contain host cell proteins (HCP) as impurities. While there is no clear evidence of clinical adverse events attributable to HCP, HCP levels and profiles must be documented to meet regulatory requirements and to understand the consistency of the biological product and manufacturing process. We present a general strategy for HCP characterization applied to a recombinant protein antigen, Hepatitis B surface antigen (HBsAg) used in a multivalent vaccine...
May 31, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29807968/evaluation-of-relationship-between-exposure-parameters-and-maxillofacial-bone-quality-with-salivary-glands-absorbed-dose-in-cone-beam-computed-tomography-imaging
#5
Mojdeh Mehdizadeh, Shervin Bagherieh
AIM: The purpose of this study was to evaluate the protective effect of jaw bone on the dose of salivary glands and its relationship with radiation conditions. MATERIALS AND METHODS: In this cross-sectional study, seven dried human skulls were used. In each mandible, six dosimeters were placed in six salivary gland regions numbered in visible light absorbent envelopes. Cone beam computed tomography (CBCT) images were taken from each mandible with a constant kV of 90 and mA varied from 6, 8, and 10...
May 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29774712/-diagnostic-imaging-procedures-and-prescribing-appropriateness-are-administrative-data-a-proper-instrument-an-experience-from-piedmont-region-northern-italy
#6
Eva Pagano, Laura Crosetto, Andrea Evangelista, Chiara Monagheddu, Ottavio Davini, Giulio Fornero, Ida Raciti, Guido Giustetto, Giovannino Ciccone
OBJECTIVES: to assess at population level if healthcare administrative data can be suitable to identify variability and determinants of the prescribing rates for some diagnostic imaging procedures at high-risk of inappropriateness. DESIGN: population-based observational study. SETTING AND PARTICIPANTS: Piedmont Region (Northern Italy) adult population (>20 years) in year 2013. The subjects included were 3,566,147, referring to 3,016 general practitioners (GPs), in 12 Local Health Authorities (LHAs)...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29754949/interpretation-of-dual-energy-x-ray-absorptiometry-derived-body-composition-change-in-athletes-a-review-and-recommendations-for-best-practice
#7
REVIEW
Karen Hind, Gary Slater, Brian Oldroyd, Matthew Lees, Shane Thurlow, Matthew Barlow, John Shepherd
Dual-energy X-ray absorptiometry (DXA) is a medical imaging device which has become the method of choice for the measurement of body composition in athletes. The objectives of this review were to evaluate published longitudinal DXA body composition studies in athletic populations for interpretation of "meaningful" change, and to propose a best practice measurement protocol. An online search of PubMed and CINAHL via EBSCO Host and Web of Science enabled the identification of studies published until November 2016...
March 23, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29753150/identification-of-asymptomatic-frailty-vertebral-fractures-in-post-menopausal-women
#8
S Pizzato, C Trevisan, P Lucato, G Girotti, M Mazzochin, B M Zanforlini, G Bano, F Piovesan, A Bertocco, F Zoccarato, M Dianin, E Manzato, G Sergi
PURPOSE: Vertebral fractures are associated with persistent pain, disability and mortality. However, around two thirds of women with vertebral fractures are unaware of them. We aimed to analyze which factors could mostly be associated to the presence of vertebral fractures in post-menopausal women, and evaluate the effectiveness of current screening criteria for the detection of vertebral fractures in an outpatient setting. METHODS: We evaluated 1132 post-menopausal women referred to the osteoporosis outpatient clinic of the Geriatrics Department of Padova...
August 2018: Bone
https://www.readbyqxmd.com/read/29703451/osteoporosis-bone-mineral-density-and-ckd-mbd-complex-i-diagnostic-considerations
#9
Jordi Bover, Pablo Ureña-Torres, Josep-Vicent Torregrosa, Minerva Rodríguez-García, Cristina Castro-Alonso, José Luis Górriz, Ana María Laiz Alonso, Secundino Cigarrán, Silvia Benito, Víctor López-Báez, María Jesús Lloret Cora, Iara daSilva, Jorge Cannata-Andía
Osteoporosis (OP) and chronic kidney disease (CKD) independently influence bone and cardiovascular health. A considerable number of patients with CKD, especially those with stages 3a to 5D, have a significantly reduced bone mineral density leading to a high risk of fracture and a significant increase in associated morbidity and mortality. Independently of classic OP related to age and/or gender, the mechanical properties of bone are also affected by inherent risk factors for CKD ("uraemic OP"). In the first part of this review, we will analyse the general concepts regarding bone mineral density, OP and fractures, which have been largely undervalued until now by nephrologists due to the lack of evidence and diagnostic difficulties in the context of CKD...
April 24, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29681439/bone-mineral-density-distribution-curves-in-spanish-adults-with-down-syndrome
#10
Ramón Costa, Alejandra Gullón, Rosa De Miguel, Diego Real de Asúa, Azucena Bautista, Clara García, Carmen Suarez, Santos Castañeda, Fernando Moldenhauer
According to reports from small-sized case series, adults with Down syndrome (DS) appear to have lower bone mineral density (BMD) than the general population. The objective of our study was to further characterize the bone mass acquisition curve in an adult DS population. This is a retrospective study of 297 adults with DS from the Adult Down Syndrome Outpatient Clinic of a tertiary care hospital in Madrid, Spain, who underwent a bone densitometry (Hologic QDR-4500W), for clinical purposes between January 2010 and June 2015...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29675043/cardiovascular-risk-factors-after-childhood-cancer-treatment-are-independent-of-the-fto-gene-polymorphism
#11
Małgorzata Sawicka-Żukowska, Maryna Krawczuk-Rybak, Paweł Bernatowicz, Katarzyna Muszyńska-Rosłan, Jerzy Konstantynowicz, Włodzimierz Łuczyński
The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer ( N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic ( FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as many as 42.5%. At least one abnormality in lipid metabolism was observed in 35...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29664757/primary-hyperparathyroidism-recent-advances
#12
Marcella D Walker, John P Bilezikian
PURPOSE OF REVIEW: The purpose of this review is to describe recent advances and changes in the evaluation and management of primary hyperparathyroidism (PHPT). RECENT FINDINGS: Although it has long been recognized that asymptomatic PHPT is associated with bone loss, particularly at cortical skeletal sites when evaluated with dual-energy X-ray absorptiometry, new imaging techniques suggest that trabecular skeletal deterioration as well as clinically silent vertebral fractures and nephrolithiasis are common...
July 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29661688/effect-of-positioning-of-the-roi-on-bmd-of-the-forearm-and-its-subregions
#13
Elizabeth O Rosen, Elizabeth A McNamara, LaTarsha G Whittaker, Alan O Malabanan, Harold N Rosen
Inconsistent positioning of patients and region of interest (ROI) is known to influence the precision of bone mineral density (BMD) measurements in the spine and hip. However, it is unknown whether minor shifts in the positioning of the ROI along the shaft of the radius affect the measurement of forearm BMD and its subregions. The ultradistal (UD-), mid-, one-third, and total radius BMDs of 50 consecutive clinical densitometry patients were acquired. At baseline the distal end of the ROI was placed at the tip of the ulnar styloid as usual, and then the forearm was reanalyzed 10 more times, each time shifting the ROI 1 mm proximally...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29649091/the-prognostic-significance-of-pedicle-enhancement-from-contrast-enhanced-mri-for-the-further-collapse-in-osteoporotic-vertebral-compression-fractures
#14
Sung Eun Hyun, Jin Young Ko, Eugene Lee, Ju Seok Ryu
STUDY DESIGN: Retrospective observational study. OBJECTIVE: The aim of this study was to investigate the prognostic significance of contrast-enhanced MRI for detecting pedicle enhancement and predicting future collapse in patients with acute benign osteoporotic vertebral compression fracture (OVCF). SUMMARY OF BACKGROUND DATA: Traditional morphological classification regarding compression versus burst fractures cannot accurately anticipate the prognosis of further collapse...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29615834/corneal-clarity-measurements-in-patients-with-keratoconus-undergoing-either-penetrating-or-deep-anterior-lamellar-keratoplasty
#15
Khaled Alzahrani, Syarifah-Faiza Dardin, Fiona Carley, Arun Brahma, Debbie Morley, M Chantal Hillarby
Purpose: To compare the corneal clarity measurement between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) in patients with keratoconus, using densitometry software for the Oculus Pentacam. Methods: A retrospective comparative study was carried out at Manchester Royal Eye Hospital. Data were collected 12-18 months after corneal transplantation for keratoconus, including postoperative corneal densitometry, best corrected visual acuity (BCVA), central corneal thickness (CCT), and other relevant clinical details...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29605092/evaluation-of-a-vaccination-regimen-and-care-in-relation-to-follow-up-and-treatment-of-patients-with-inflammatory-bowel-disease
#16
J K Yamamoto-Furusho, A Sarmiento-Aguilar, N N Parra-Holguín, K E Bozada-Gutiérrez
INTRODUCTION AND AIMS: During the clinical course of inflammatory bowel disease, different causes can compromise kidney, liver, and bone marrow function and increase the risk for osteoporosis, infections, and neoplasias. The aim of the present study was to describe the follow-up of Mexican patients with inflammatory bowel disease in relation to their vaccination regimen, treatment-associated risks, and cancer screening. MATERIALS AND METHODS: A retrospective cross-sectional study was conducted within the time frame of February and June 2017...
March 28, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29567290/effects-of-curcumin-on-bone-loss-and-biochemical-markers-of-bone-turnover-in-patients-with-spinal-cord-injury
#17
Masoud Hatefi, Mohammad Reza Hafezi Ahmadi, Asghar Rahmani, Masoud Moghadas Dastjerdi, Khairollah Asadollahi
BACKGROUND: Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS: The current controlled clinical trial was conducted among 100 patients with SCI referred to an outpatient clinic of rehabilitation in Ilam City, Iran, in 2013-2015. The intervention group received 110/mg/kg/day curcumin for 6 months and the control group received placebo...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29551009/assessment-of-physical-performance-and-body-composition-in-male-renal-transplant-patients
#18
Andrea Petronio Rossi, Gianluigi Zaza, Marina Zanardo, Francesco Pedelini, Laura Dalla Verde, Chiara Caletti, Alessia D'Introno, Antonio Lupo, Mauro Zamboni
BACKGROUND: Renal transplant (RTX) recipients seem to experience a better quality of life compared to dialysis patients. However, the factors responsible for this positive effect are not completely defined. Conceivably, a change in the physical performance of these patients could play a role. METHODS: To assess this, we measured: (1) waist circumference, fat mass and appendicular fat-free mass (aFFM) by dual-energy X-ray densitometry, (2) physical performance with the Short Physical Performance Battery, and (3) muscle strength with the handgrip test, in 59 male RTX, 11 chronic kidney disease in conservative treatment (CKD) and 10 peritoneal dialysis (PD) patients...
March 17, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29549461/assessment-of-corneal-backward-light-scattering-in-the-healthy-cornea-and-factors-affecting-corneal-transparency
#19
Ali Bulent Cankaya, Kemal Tekin, Hasan Kiziltoprak, Sevilay Karahan, Pelin Yilmazbas
PURPOSE: To quantify normative corneal optical density (COD) values of healthy individuals and to investigate alterations in the COD in relation to their ocular and demographic characteristics. STUDY DESIGN: Prospective, cross-sectional, and observational. METHODS: In total, 588 eyes from 588 healthy participants with clear corneas were consecutively enrolled. Corneal densitometry values expressed in standardized grayscale units (GSU) from different corneal layers and zones obtained using the rotating Pentacam Scheimpflug system were analyzed...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29537886/corneal-densitometry-after-femtosecond-laser-assisted-in-situ-keratomileusis-fs-lasik-and-small-incision-lenticule-extraction-smile
#20
Mehdi Shajari, Emanuel Wanner, Vladimir Rusev, Shervin Mir Mohi Sefat, Wolfgang J Mayer, Thomas Kohnen, Siegfried Priglinger, Daniel Kook
PURPOSE: To compare corneal densitometry values after Femtosecond Laser-Assisted In Situ Keratomileusis (Fs-LASIK) and Small Incision Lenticule Extraction (SMILE) using Scheimpflug Imaging. METHODS: Our retrospective clinical trial included a total of 146 eyes where 57 eyes underwent Fs-LASIK and 89 eyes underwent SMILE. Examinations with a Pentacam Scheimpflug device (Oculus, Wetzlar, Germany) were performed before surgery, 1 week, 1 month, 3 months, 6 months, and 1 year after surgery...
May 2018: Current Eye Research
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