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abortus septic

Jürgen Benjamin Hagemann, Ulrike Simnacher, David Longbottom, Morag Livingstone, Julia Maile, Erwin Soutschek, Gernot Walder, Katharina Boden, Konrad Sachse, Andreas Essig
The obligate intracellular bacterium Chlamydia abortus is the causative agent of enzootic abortion of ewes and poses a significant zoonotic risk for pregnant women. Using proteomic analysis and gene expression library screening in a previous project, we identified potential virulence factors and candidates for serodiagnosis, of which nine were scrutinized here with a strip immunoassay. We have shown that aborting sheep exhibited a strong antibody response to surface (MOMP, MIP, Pmp13G) and virulence-associated (CPAF, TARP, SINC) antigens...
July 2016: Journal of Clinical Microbiology
Keun Hwa Lee, Hyunseong Kang, Taejung Kim, Sungwook Choi
We present a 51-year-old male patient with Brucella abortus septic arthritis in the right knee following arthroscopic meniscus surgery. He had eaten a traditional dish of raw minced cattle conceptus (bovine fetus) that was prepared after the cow was slaughtered. Despite treatment with empirical antibiotics and debridement of the postoperative surgical wound, the infection persisted without improvement. Polymerase chain reaction sequencing identified Brucella abortus from tissue samples obtained from the patient...
2016: Acta Orthopaedica et Traumatologica Turcica
L del Rio, M Barberá-Cremades, J A Navarro, A J Buendía, F Cuello, N Ortega, M C Gallego, J Salinas, M R Caro
Intragastric infection mimics the natural route of infection of Chlamydia abortus (etiological agent of ovine enzootic abortion). In the mouse model, intragastric experimental infection induces very mild signs of infection followed by late term abortions, as it is shown by the natural ovine host. In order to evaluate the immune mechanisms associated to the dissemination of the pathogen from the gastrointestinal tract, we have administered an intragastric dose of C. abortus to pregnant mice. Systemic and local expression of cytokines, tissue colonization and excretion of bacteria after parturition were monitored during pregnancy...
March 2013: Microbial Pathogenesis
S Worrall, D J Sammin, H F Bassett, C R Reid, J Gutierrez, P X Marques, J E Nally, J O'Donovan, E J Williams, A Proctor, B K Markey
Pregnant ewes were challenged with Chlamydia abortus at 91-98 days of gestation and euthanised at 14, 21 and 28 days post-challenge. IFNγ mRNA labelling appeared to be co-localised with Chlamydial lipopolysaccharide within trophoblast cells in discrete areas lining the primary villi in the limbus and hilar zone of the placentomes from challenged sheep on days 21 and 28 post-infection. The presence of IFNγ was also demonstrated by immunohistochemistry. No labelling was seen in tissues from the non-infected ewes...
August 2011: Journal of Reproductive Immunology
Jorge C Wallach, M Victoria Delpino, Romina Scian, Bettina Deodato, Carlos A Fossati, Pablo C Baldi
A case of prepatellar bursitis in a man with chronic brucellosis is presented. Brucella abortus biotype 1 was isolated from the abundant yellowish fluid obtained from the bursa. Clinical and epidemiological data did not suggest a direct inoculation of the agent in the bursa. However, the patient mentioned occasional local trauma due to recreational sports, which may have constituted a predisposing factor. As determined by ELISA, there were higher levels of IgG against Brucella LPS and cytosolic proteins detected in the patient's bursal synovial fluid when compared with serum...
December 2010: Journal of Medical Microbiology
Gary Entrican, Sean Wattegedera, Nick Wheelhouse, Alasdair Allan, Mara Rocchi
Successful mammalian pregnancy involves complex immunological interactions between the mother and foetus that are not yet fully understood. A number of immunological paradigms have been established to explain the failure of the maternal immune system to reject the semi-allogeneic foetus, mainly based on studies in mice and humans. However, as placental structure, gestation periods and number of concepti per pregnancy can vary greatly between mammals, it is not always clear how applicable these immunological paradigms are to reproduction in other species...
October 2010: American Journal of Reproductive Immunology: AJRI
S C Olsen, S M Boyle, G G Schurig, N N Sriranganathan
Vaccination is a tool that could be beneficial in managing the high prevalence of brucellosis in free-ranging bison in Yellowstone National Park. In this study, we characterized immunologic responses and protection against experimental challenge after vaccination of bison with Brucella abortus strain RB51 (RB51) or a recombinant RB51 strain overexpressing superoxide dismutase (sodC) and glycosyltransferase (wboA) genes (RB51+sodC,wboA). Bison were vaccinated with saline only or with 4.6 x 10(10) CFU of RB51 or 7...
April 2009: Clinical and Vaccine Immunology: CVI
M A González-Gay, R Blanco, M J García-Pais, P Alonso, A Rodríguez, A Coira, J Mayo
No abstract text is available yet for this article.
April 1997: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Kenta Watanabe, Masato Tachibana, Satoshi Tanaka, Hidefumi Furuoka, Motohiro Horiuchi, Hiroshi Suzuki, Masahisa Watarai
BACKGROUND: The cell tropism of Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in the placenta is thought to be a key event of infectious abortion, although the molecular mechanism for this is largely unknown. There is a higher degree of bacterial colonization in the placenta than in other organs and many bacteria are detected in trophoblast giant (TG) cells in the placenta. In the present study, we investigated mechanism of B. abortus invasion into TG cells...
2008: BMC Microbiology
A I Mallick, H Singha, S Khan, T Anwar, M A Ansari, R Khalid, P Chaudhuri, M Owais
Brucellosis is an important zoonotic disease that causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. In spite of the fact that immunization could be an efficient measure to control brucellosis, not a single ideal vaccine against this important disease has been developed so far. In order to develop an effective vaccine against Brucella abortus (B. abortus), various protective immunodominant gene/protein products of the pathogen have been studied in combination with different adjuvants...
November 14, 2007: Vaccine
Elías Barquero-Calvo, Esteban Chaves-Olarte, David S Weiss, Caterina Guzmán-Verri, Carlos Chacón-Díaz, Alexandra Rucavado, Ignacio Moriyón, Edgardo Moreno
BACKGROUND: To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. METHODOLOGY/PRINCIPAL FINDINGS: Brucella did not induce proinflammatory responses as demonstrated by the absence of leukocyte recruitment, humoral or cellular blood changes in mice. Brucella hampered neutrophil (PMN) function and PMN depletion did not influence the course of infection. Brucella barely induced proinflammatory cytokines and consumed complement, and was strongly resistant to bactericidal peptides, PMN extracts and serum...
2007: PloS One
A Meijer, A Brandenburg, J de Vries, J Beentjes, P Roholl, D Dercksen
Reported here is the case of a pregnant woman who developed a severe Chlamydophila abortus infection after indirect contact with infected goats resulting in preterm stillbirth. The woman fully recovered after treatment with doxycycline. In the goat herd with which her husband worked Chlamydophila abortus was actively circulating, as shown by positive serology. When pregnant women present with rapidly worsening influenza-like illness, special attention should be given to possible contact (direct or indirect) with animals when recording the anamnesis...
June 2004: European Journal of Clinical Microbiology & Infectious Diseases
No abstract text is available yet for this article.
April 14, 1951: Veterinary Record
No abstract text is available yet for this article.
December 30, 1950: Veterinary Record
No abstract text is available yet for this article.
February 1951: Veterinary Medicine
No abstract text is available yet for this article.
October 7, 1950: Veterinary Record
L López-Urrutia, A Alonso, M L Nieto, Y Bayón, A Orduña, M Sánchez Crespo
Smooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of production of NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) was confirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observations might help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septic shock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans...
March 2000: Infection and Immunity
O Arrieta, A Ortiz-Reyes, D Rembao, M Calvillo, E Rivera, J Sotelo
Mortality caused by septic shock in experimental animals is reduced by thalidomide, an inhibitor of tumour necrosis factor alpha. Another drug that could act on the pathophysiological mechanisms of septic shock is pentoxifylline, an inhibitor of platelet aggregation that increases the flexibility of the erythrocyte membrane and has fibrinolytic activity. We studied the effect of pentoxifylline alone and combined with thalidomide in septic shock; 97 NIH mice were injected with lipopolysaccharides of Salmonella abortus equi and D galactosamine...
February 1999: International Journal of Experimental Pathology
C García-Porrúa, M A González-Gay, D Ibañez, M J García-País
OBJECTIVE: To assess the clinical and microbiological characteristics of septic bursitis in those cases that required treatment at the hospital during the past 10 years in a northwestern area of Spain. METHODS: The charts of all patients diagnosed as having septic bursitis at Hospital Xeral-Calde, Lugo, Spain, from October 1987 through September 1997 were reviewed based on published criteria and graded according to severity. RESULTS: Sixty-nine patients diagnosed with definite and 6 with probable septic bursitis met the criteria for severe septic bursitis...
March 1999: Journal of Rheumatology
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