Marinos Kosmopoulos, Martina Chiriacò, Kimon Stamatelopoulos, Costas Tsioufis, Pier Giorgio Masci, Christos Kontogiannis, Alessandro Mengozzi, Nicola Riccardo Pugliese, Stefano Taddei, Agostino Virdis, Stefano Masi, Georgios Georgiopoulos
Accelerated biological aging contributes to the evolution of cardiovascular disease. However, its influence on subclinical organ damage remains unclear. Leukocyte telomere length (LTL) is emerging as a marker of biological cardiovascular aging. We performed a systematic review and meta-analysis to assess the association between LTL and measures of end-organ damage. PubMed, Medline, Embase, Cinahl Plus, ClinicalTrials.gov, and grey literature databases were searched for studies that assessed the association of LTL with arterial pulse wave velocity (aPWV), carotid intima-media thickness (cIMT), left ventricular mass (LVM or LVMI), renal outcomes, coronary artery calcium (CAC) and presence of carotid plaques...
January 2022: Mechanisms of Ageing and Development