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https://www.readbyqxmd.com/read/29348307/non-mammalian-models-of-multiple-endocrine-neoplasia-type-2
#1
REVIEW
Tirtha K Das, Ross L Cagan
Twenty-five years ago, RET was identified as the primary driver of multiple endocrine neoplasia type 2 (MEN2) syndrome. MEN2 is characterized by several transformation events including pheochromocytoma, parathyroid adenoma and, especially penetrant, medullary thyroid carcinoma (MTC). Overall, MTC is a rare but aggressive type of thyroid cancer for which no effective treatment currently exists. Surgery, radiation, radioisotope treatment and chemotherapeutics have all shown limited success, and none of these approaches have proven durable in advanced disease...
February 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29345728/analytical-performance-of-the-thyroseq-v3-genomic-classifier-for-cancer-diagnosis-in-thyroid-nodules
#2
Marina N Nikiforova, Stephanie Mercurio, Abigail I Wald, Michelle Barbi de Moura, Keith Callenberg, Lucas Santana-Santos, William E Gooding, Linwah Yip, Robert L Ferris, Yuri E Nikiforov
BACKGROUND: Molecular tests have clinical utility for thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology, although their performance requires further improvement. This study evaluated the analytical performance of the newly created ThyroSeq v3 test. METHODS: ThyroSeq v3 is a DNA- and RNA-based next-generation sequencing assay that analyzes 112 genes for a variety of genetic alterations, including point mutations, insertions/deletions, gene fusions, copy number alterations, and abnormal gene expression, and it uses a genomic classifier (GC) to separate malignant lesions from benign lesions...
January 18, 2018: Cancer
https://www.readbyqxmd.com/read/29344163/clinical-characteristics-and-treatment-outcomes-of-parathyroid-carcinoma-a-retrospective-review-of-234-cases
#3
Peisong Wang, Shuai Xue, Shuo Wang, Zhi Lv, Xianying Meng, Guimin Wang, Wei Meng, Jia Liu, Guang Chen
Parathyroid carcinoma (PC) is one of the rarest known types of cancer and has a moderate prognosis, with estimated 5- and 10-year overall survival rates between 78-85% and between 49-70%, respectively. To raise awareness of this disease, and to optimize its diagnosis, clinical management and prognosis, the present study retrospectively reviewed 234 cases of PC. A total of 226 cases of PC, which were archived between 1984 and 2015 in the three major databases of the Chinese population, were retrieved and pooled with the 8 cases diagnosed and treated at the Department of Thyroid Surgery of The First Hospital of Jilin University (Changchun, China) between June 2008 and December 2015...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29340158/follicular-thyroid-cancer-avid-on-c-11-methionine-pet-ct
#4
Mads Ryø Jochumsen, Peter Iversen, Anne Kirstine Arveschoug
A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates the potential incremental value of this modality, not only in the localizing of parathyroid adenoma, but also indicating that 11C-Methionine PET might have a potential of increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29340121/complications-of-transfusion-dependent-%C3%AE-thalassemia-patients-in-sistan-and-baluchistan-south-east-of-iran
#5
Maryam Yaghobi, Ebrahim Miri-Moghaddam, Naderi Majid, Ali Bazi, Ali Navidian, Asiyeh Kalkali
Background: Thalassemia syndromes are among prevalent hereditary disorders imposing high expenses on health-care system worldwide and in Iran. Organ failure represents a life-threatening challenge in transfusion- dependent β-thalassemia (TDT) patients. The purpose of the present study was to determine the frequency of organ dysfunctions among TDT patients in Sistan and Baluchistan province in South-East of Iran. Materials and Methods: Laboratory and clinical data were extracted from medical records as well as by interviews...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29330195/dicer1-gene-mutations-in-endocrine-tumors
#6
Michael Solarski, Fabio Rotondo, William Foulkes, John R Priest, Luis V Syro, Henriett Butz, Michael Cusimano, Kalman Kovacs
In this review, the importance of the DICER1 gene in the function of endocrine cells is discussed. There is conclusive evidence that DICER1 mutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature of DICER1 gene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian, and testicular tumors. Although significant progress has been made during the last few years, much more work is needed to fully understand the significance of DICER1 mutations...
January 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29322025/short-and-long-term-impact-of-parathyroid-autotransplantation-on-parathyroid-function-after-total-thyroidectomy
#7
REVIEW
Gabrielle Hicks, Robert George, Mark Sywak
The most common complication of total thyroidectomy is parathyroid insufficiency. Acute, transient, post-operative hypoparathyroidism increases length of hospitalization, morbidity and cost associated with total thyroidectomy. While permanent hypoparathyroidism poses a significant medical burden with lifetime medication, regular follow up and considerable disease burden related to chronic renal failure and other sequelae. Parathyroid autotransplantation has been demonstrated to result in biochemically functional grafts, leading to the procedures' common use during total thyroidectomy...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29322023/incidence-prevalence-and-risk-factors-for-post-surgical-hypocalcaemia-and-hypoparathyroidism
#8
REVIEW
Ovie Edafe, Sabapathy Prakash Balasubramanian
Hypocalcaemia following thyroid surgery is common and is associated with significant short and long term morbidity. Damage to or devascularisation of parathyroid glands is the predominant underlying mechanism; although other factors such as hungry bone syndrome may occasionally contribute to it in the immediate post-operative period. The reported incidence of post-surgical hypocalcaemia and/or hypoparathyroidism (PoSH) varies significantly in the literature; the variation thought to be at least partly due to differences in the definitions used...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29322020/a-reappraisal-of-vascular-anatomy-of-the-parathyroid-gland-based-on-fluorescence-techniques
#9
REVIEW
Samira Mercedes Sadowski, Jordi Vidal Fortuny, Frederic Triponez
Identification of the parathyroid glands (PGs) during thyroid surgery may prevent their inadvertent surgical removal and prevent postoperative hypoparathyroidism. However, identification of the PGs does not guarantee their function, and their vascular supply needs to be preserved as well. The recent introduction of intraoperative indocyanine green (ICG) fluorescent angiography of the PGs during thyroid surgery allows for the appraisal of the vascular anatomy and evaluation of PG function. The use of this tool could lead to a significant reduction in the rate of postoperative hypoparathyroidism, as it allows surgeons to adapt their surgical technique for the preservation of the PGs...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29322019/to-identify-or-not-to-identify-parathyroid-glands-during-total-thyroidectomy
#10
REVIEW
Yuk Kwan Chang, Brian H H Lang
Hypoparathyroidism is one of the most common complications after total thyroidectomy and may impose a significant burden to both the patient and clinician. The extent of thyroid resection, surgical techniques, concomitant central neck dissection, parathyroid gland (PG) autotransplantation and inadvertent parathyroidectomy have long been some of the risk factors for postoperative hypoparathyroidism. Although routine identification of PGs has traditionally been advocated by surgeons, recent evidence has suggested that perhaps identifying fewer number of in situ PGs during surgery (i...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29303141/synchronous-parathyroid-adenoma-and-papillary-thyroid-carcinoma-99mtc-mibi-scan-findings
#11
O Kandemir, P Atmaca Kelkit, K Karakuş
Simultaneous existence of parathyroid adenoma and thyroid nonmedullary carcinoma is rarely observed. A 52-year-old female was diagnosed approximately 4 years ago with primary hyperparathyroidism (PHPT) on the basis of hypercalcemia and elevated serum parathyroid hormone (PTH) level. Clinically, PHPT diagnosed patient was examined with Tc-99m MIBI scintigraphy to investigate parathyroid adenoma. Early Tc-99m MIBI images showed focal focused enhanced activity retention on both thyroid left lobe upper pole and thyroid lower pole inferior neighborhood...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29303067/modified-tumescent-solution-for-creating-working-space-during-endoscopic-thyroidectomy
#12
Li-Yong Zhang, Wen-Xin Zhao, Bo Wang, Shou-Yi Yan, Jia Wen
OBJECTIVE: To study the feasibility of gas-liquid mixing tumescent solution for creating a working space (WS) in endoscopic thyroidectomy (ET). MATERIALS AND METHODS: A prospective study was performed on 186 patients with thyroid tumor who had undergone ET via chest and breast approach. Patients were randomly divided into 2 groups to receive traditional tumescent solution as group A and modified tumescent solution (gas-liquid mixing tumescent solution) as group B...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29302725/does-surgery-without-lugol-s-solution-pretreatment-for-graves-disease-increase-surgical-morbidity
#13
Frederic Mercier, Mathieu Bonnal, Florian Fanget, Laure Maillard, Nathalie Laplace, Jean-Louis Peix, Jean-Christophe Lifante
BACKGROUND: Total thyroidectomy can be performed for Graves' disease after a euthyroid state is achieved using inhibitors of thyroid hormone synthesis (thioamides). However, hypervascularization of the thyroid gland is associated with increased hemorrhage risk, in addition to complicating identification of the recurrent laryngeal nerve and parathyroid gland. Saturated iodine solution (Lugol's solution) has been recommended to reduce thyroid gland hypervascularization and intraoperative blood loss, although this approach is not used at our center based on our experience that it induces thyroid firmness and potentially hypoparathyroidism...
January 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29302491/an-ectopic-intrathyroidal-thymic-tissue-and-intrathymic-parathyroid-tissue-in-a-patient-with-graves-disease
#14
Kelly O'Connor, Hassan Alzahrani, Fadi Murad, Philip Daroca, Emad Kandil
Ectopic intrathyroidal thymic tissue, with coinciding intrathymic parathyroid tissue, is a very rare occurrence that is most often found incidentally in adults during surgery. We report a 23-year-old female who presented with Graves disease refractory to medical treatment. Radioactive iodine uptake demonstrated increased, diffuse uptake in the region of the thyroid. The patient underwent a total thyroidectomy and right inferior parathyroidectomy which was found enlarged intraoperatively. Histopathologically, surgical specimen demonstrated characteristics of intrathyroidal thymic tissue and intrathymic parathyroid tissue...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29302484/inadvertent-parathyroidectomy-risk-factors-in-1-373-thyroidectomies-male-gender-and-presence-of-lymphadenopathy-but-not-size-of-gland-independently-increase-the-risk
#15
Ioannis Christakis, Penny Zacharopoulou, Georgios Galanopoulos, Ilias-Demetrios Kafetzis, Spiros Dimas, Nikolaos Roukounakis
Background: Inadvertent parathyroidectomy (IP) during thyroid operations is a recognised phenomenon. We evaluated the incidence of IP during thyroid operations in a large case-series and identified the risk factors involved. Methods: Retrospective review of all thyroidectomy operations [total thyroidectomies (TT) and near-total thyroidectomies (NTT)] performed in a single institution from January 2004 to January 2009. We excluded re-operative cases, combined thyroid and parathyroid pathology, hemithyroidectomies and neck lymph nodes (LN) dissections...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29302480/comparison-of-indocyanine-green-fluorescence-and-parathyroid-autofluorescence-imaging-in-the-identification-of-parathyroid-glands-during-thyroidectomy
#16
Bora Kahramangil, Eren Berber
Background: Indocyanine green fluorescence (ICGF) and parathyroid autofluorescence (AF) are two new techniques that aid in the identification of parathyroid glands (PG) intraoperatively during thyroidectomy. There is no study comparing the efficacy of these techniques. Methods: This was an IRB-approved clinical study comparing the utility of ICGF and AF for identification of PGs during thyroidectomy. Data were collected prospectively. Both techniques were compared to naked eye (NE) for PG detection...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29301864/effect-of-autotransplantation-of-a-parathyroid-gland-on-hypoparathyroidism-after-total-thyroidectomy
#17
Anping Su, Yanping Gong, Wenshuang Wu, Rixiang Gong, Zhihui Li, Jingqiang Zhu
BACKGROUND: The effect of parathyroid autotransplantation on hypoparathyroidism is not fully understood. The purpose of the study was to determine the effect of autotransplantation of a parathyroid gland on the incidence of hypoparathyroidism and recovery of parathyroid function at 6 months after total thyroidectomy with central neck dissection for papillary thyroid carcinoma. METHODS: All patients with autotransplantation of a parathyroid gland (no inadvertent parathyroidectomy) (group A), in situ preservation of all parathyroid glands (no autotransplantation and inadvertent parathyroidectomy) (group B), or inadvertent removal of a parathyroid gland (no autotransplantation) (group C) who underwent first-time total thyroidectomy with central neck dissection for papillary thyroid carcinoma between January 2013 and June 2016 were included retrospectively...
January 4, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29299645/transcutaneous-laryngeal-ultrasonography-for-laryngeal-immobility-diagnosis-in-patients-with-voice-disorders-after-thyroid-parathyroid-surgery
#18
Diane S Lazard, Héloïse Bergeret-Cassagne, Muriel Lefort, Laurence Leenhardt, Gilles Russ, Frédérique Frouin, Christophe Trésallet
BACKGROUND: Transcutaneous laryngeal ultrasonography (TLUS) was recently developed to assess recurrent nerve palsy after thyroid/parathyroid surgery, with variable rates of efficiency. The aim of the current study was to evaluate this technique using subjective estimation and post-processing quantitative data. METHODS: Fifty subjects presenting with a recurrent nerve palsy and 50 "controls" presenting with voice, swallowing, or breathing disorders following thyroid/parathyroid surgery were prospectively included...
January 3, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29288583/applications-of-3-dimensional-ultrasonography-in-the-neck-excluding-the-thyroid
#19
Susan J Frank, Tova Koenigsberg, David Gutman, Mordecai Koenigsberg
Ultrasonography (US) of the neck is an accepted, useful imaging modality for many applications beyond its usefulness in thyroid disease. Two-dimensional US has been effectively used for evaluation of many types of neck conditions, and now, 3-dimensional US can be added to the imaging armamentaria. Three-dimensional US is useful in the evaluation of cervical lymph nodes, recurrent/residual thyroid neoplasia, parathyroid glands, parotid and submandibular glands, as well as thyroglossal duct cysts and other assorted palpable and visible abnormalities because of its unique capabilities, including multiplanar reconstruction, accessibility of the coronal view, volume calculation, and regularly spaced incremental slice evaluation...
December 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29286522/pilot-study-of-parathyroid-glands-in-adult-and-pediatric-subjects-exposed-to-ionizing-radiation-after-the-chnpp-accident-methodology-of-parathyroid-diagnostic-ultrasound
#20
O V Kaminskyi, O V Kopylova, D Ye Afanasyev, O V Mazurenko, S Ya Berezovskyi
OBJECTIVE: Estimation of the parathyroid hyperplasia prevalence after the ChNPP accident in adults exposed to ion izing radiation and their descendants using the diagnostic ultrasound and its methodology elaboration. MATERIALS AND METHODS: The pilot prospective study of the prevalence of parathyroid hyperplasia among the Chornobyl Nuclear Power Plant (ChNPP) accident adult survivors (n=686) and their descendants (54 children) was performed using diagnostic ultrasound examination of thyroid and parathyroids...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
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