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https://www.readbyqxmd.com/read/29767477/effect-of-neurological-monitoring-in-postoperative-5-15-days-residual-thyroidectomy-after-primary-thyroid-cancer-surgery
#1
Miao-Yun Long, Fei-Yu Diao, Li-Na Peng, Lang-Ping Tan, Yue Zhu, Kai Huang, Hong-Hao Li
AIM: To explore the application of intraoperative neurological monitoring in residual thyroidectomy 5-15 days after thyroid cancer operation and the influence on postoperative serum thyroglobulin (Tg), recurrent laryngeal nerve and function of parathyroid glands. METHODS: Material of patients receiving thyroid surgery from January 2010 to December 2016 was retrospectively analyzed. Cases meeting with standards were enrolled for analysis and the patients were divided into neurological monitoring group and non-neurological monitoring group in line with the use of neurological monitoring during the operation...
May 16, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29757564/-re-operation-treatment-in-uremic-patients-complicated-with-persistent-secondary-hyperparathyroidism-after-parathyroidectomy-with-autotransplantation
#2
Shao Jun Bo, Xian Fa Xu, Chuan Ya Qiu, Tian Tian Wang, Yu Dong Ning, Hong Yue Li
Objective: To analyze the clinical profile and therapeutic effect of re-operation treatment in uremic patients complicated with persistent secondary hyperparathyroidism(SHPT)after parathyroidectomy with autotransplantation. Method: Twelve persistent SHPT patients who were treated with reoperation of paramyroidectomy(PTX)were enrolled in this study during the period from Jan 2014 to Jul 2017 in our hospital.We evaluated the location of the remaining parathyroid glands by ultrasonography,dual-phase 99 Tcm-sestamibi scintigraphy,CT and MR imaging of the neck before the operation...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#3
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29747960/postoperative-hypoparathyroidism-after-total-thyroidectomy-for-thyroid-cancer
#4
Masanori Teshima, Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-Ichi Nibu
OBJECTIVES: Postoperative hypoparathyroidism (HPT) is one of the most common complications in total thyroidectomy for thyroid carcinoma. Parathyroid glands (PTGs) are at risk of being damaged during total thyroidectomy and central neck dissection mainly due to inadvertent removal, interruption of the blood supply or hematoma formation. The purpose of this study was to evaluate the efficacy of our surgical procedure to preserve for parathyroid function retrospectively and to clarify the risk factors of HPT after total thyroidectomy for thyroid cancer...
May 7, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29744727/immunohistochemical-biomarkers-in-thyroid-pathology
#5
REVIEW
Zubair Baloch, Ozgur Mete, Sylvia L Asa
The application of immunohistochemistry to the diagnosis of thyroid lesions has increased as new biomarkers have emerged. In this review, we discuss the biomarkers that are critical for accurate diagnosis, prognosis, and management. Immunohistochemical markers are used to confirm that an unusual tumor in the thyroid is indeed of thyroid origin, either of follicular epithelial or C-cell differentiation; the various mimics include nonthyroidal lesions such as parathyroid tumors, paragangliomas, thymic neoplasms, and metastatic malignancies...
May 9, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29743975/hypothyroidism-causes-endoplasmic-reticulum-stress-in-adult-rat-hippocampus-a-mechanism-associated-with-hippocampal-damage
#6
Alejandra Paola Torres-Manzo, Margarita Franco-Colín, Vanessa Blas-Valdivia, Marisol Pineda-Reynoso, Edgar Cano-Europa
Thyroid hormones (TH) are essential for hippocampal neuronal viability in adulthood, and their deficiency causes hypothyroidism, which is related to oxidative stress events and neuronal damage. Also, it has been hypothesized that hypothyroidism causes a glucose deprivation in the neuron. This study is aimed at evaluating the temporal participation of the endoplasmic reticulum stress (ERE) in hippocampal neurons of adult hypothyroid rats and its association with the oxidative stress events. Adult Wistar male rats were divided into euthyroid and hypothyroid groups...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29724805/recognizing-pinhole-parallax-error-for-accurate-localization-of-thyroid-and-parathyroid-pathology
#7
Ismet Sarikaya, Zaina Al-Banna, Ali Baqer
Parallax error is a pitfall of pinhole scintigraphy which causes mislocalization of the objects. It is important to notice this error on pinhole thyroid and parathyroid scintigraphy and obtain additional images with parallel-hole collimator to accurately determine the upper and lower margins of large goiter and nodules and location of the ectopic thyroid tissue and parathyroid adenomas. In this teaching case report we wanted to revisit pinhole parallax error, present pinhole and SPECT/CT images of a case with large hyperactive thyroid nodule and review the literature and potential solutions to this important problem...
May 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29697378/surgical-prevention-and-treatment-of-postoperative-hypoparathyroidism-in-patients-operated-on-thyroid-gland
#8
V Skrypko, A Pasko, I Churpiy, A Kovalenko, V Zaplutanov
The objective of the research was to develop and evaluate the algorithm of prevention and treatment of postoperative hypoparathyroidism (PHPT) based on determining parathyroid glands (PTG) viability and the use of antihypoxant-antioxidant therapy in the postoperative period. The research was based on the results of a comprehensive examination and treatment of 60 patients who were operated for thyroid gland diseases. The patients underwent inpatient treatment at the surgical department of Ivano-Frankivsk Central City Clinical Hospital and Ivano-Frankivsk Regional Oncology Center from 2015 to 2017...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29668666/a-comparison-of-robotic-versus-open-thyroidectomy-for-papillary-thyroid-cancer
#9
Se Hyun Paek, Kyung Ho Kang, Sung Jun Park
OBJECTIVES: This study investigated the potential advantages of robotic thyroidectomy and determined whether it is safe and complete compared with conventional open surgery in patients with papillary thyroid cancer. MATERIALS AND METHODS: A total 376 consecutive patients who underwent total thyroidectomy and central neck dissection for papillary thyroid cancer from February 2013 to July 2014 were retrospectively reviewed. Postoperative complication rates and surgical completeness were compared between the robotic and open groups...
April 17, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29663329/prophylactic-thyroidectomy-in-children-with-multiple-endocrine-neoplasia-type-2
#10
F P Prete, T Abdel-Aziz, C Morkane, C Brain, T R Kurzawinski
BACKGROUND: In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs the timing of thyroidectomy. The efficacy of treatment, which depends on timely and safe surgery, is not well established. METHODS: This was a retrospective review of diagnostic and clinicopathological outcomes of prophylactic thyroidectomy in children with MEN2 between 1995 and 2013 in the UK...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29663312/mortality-in-patients-with-permanent-hypoparathyroidism-after-total-thyroidectomy
#11
M Almquist, K Ivarsson, E Nordenström, A Bergenfelz
BACKGROUND: Permanent hypoparathyroidism remains the most common adverse outcome after total thyroidectomy, but long-term effects of hypoparathyroidism are unknown. The aim was to investigate mortality in patients with permanent hypoparathyroidism after total thyroidectomy. METHODS: Data from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery were linked with the Swedish National Prescription Register for Pharmaceuticals and the Swedish National Inpatient Register...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29662564/dual-pathologies-of-parathyroid-adenoma-and-papillary-thyroid-cancer-on-fluorocholine-and-fluorodeoxyglucose-pet-ct
#12
N T K Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Ashwin Singh Parihar, Divya Dahiya, Priyanka Singh, Rajender Kumar Basher, Ashim Das, Bhagwant R Mittal
18 F-Fluorocholine (FCH) PET/CT is evolving as a functional imaging modality for the preoperative imaging of abnormal parathyroid tissue(s) helping to localize eutopic and ectopic parathyroid tissue and limit the extent of surgery. FCH PET/CT may show incidental uptake in various thyroid lesions necessitating further evaluation, whereas the role of 18 F-fluorodeoxyglucose (FDG) PET/CT in the detection of incidental thyroid nodules is well documented. The case of a middle-aged woman with dual pathology of parathyroid adenoma and papillary thyroid cancer detected on FCH and FDG PET/CT is presented...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662267/decrement-in-bone-mineral-density-after-parathyroidectomy-in-a-pediatric-patient-with-primary-hyperparathyroidism
#13
Hidechika Morimoto, Hisakazu Nakajima, Jun Mori, Shota Fukuhara, Keiichi Shigehara, Shinsuke Adachi, Hajime Hosoi
Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Here, we report a case of a 13-yr-old boy with PHT who was referred to our institution for evaluation of hypercalcemia and hyperparathyroidism. Radiological investigation revealed an ectopic parathyroid adenoma below the right thyroid lobe...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29658811/parathyroid-autotransplantation-during-thyroid-surgery-where-we-are-a-systematic-review-on-indications-and-results
#14
Olga Iorio, Vincenzo Petrozza, Antonietta De Gori, Marco Bononi, Natale Porta, Giorgio De Toma, Giuseppe Cavallaro
INTRODUCTION: Hypoparathyroidism still represents an important concern in thyroid surgery. Careful dissection with identification and preservation of parathyroid glands in situ remains the best way to maintain gland vitality and avoid post-operative failure. Nevertheless, parathyroid glands are still inadvertently removed in up to 11% of cases. Parathyroid autotransplantation may represent the only way to restore parathyroid gland functionality in case of inadvertent removal or devascularization during thyroid surgery...
April 16, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#15
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29626276/immunohistochemistry-in-diagnostic-parathyroid-pathology
#16
REVIEW
Lori A Erickson, Ozgur Mete
Pathologists are usually readily able to diagnose parathyroid tissues and diseases, particularly when they have knowledge of the clinical information, laboratory findings, and radiographic imaging studies. However, the identification of parathyroid tissue or lesions can be difficult in small biopsies, ectopic locations, supranumerary glands, and in some oxyphil/oncocytic lesions. Widely available immunohistochemical studies such as chromogranin-A, synaptophysin, keratin, parathyroid hormone, thyroglobulin, and thyroid transcription factor-1 can help in difficult cases...
April 7, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29607233/preterm-parturient-with-polyhydramnios-and-pancreatitis-primary-presentation-of-hyperparathyroidism
#17
Esther S Han, Katherine Fritton, Phoebe Bacon, Martin K Slodzinski, Cynthia Argani
Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes. Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Case: A 29-year-old G2P1001 woman at 35 weeks and 3 days' gestation presented with preterm contractions, polyhydramnios, pancreatitis, and severe hypercalcemia...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29595868/iatrogenic-hypoparathyroidism-after-surgery-for-retrosternal-goitre-a-single-centre-retrospective-analysis
#18
G Damiano, G Cocchiara, V D Palumbo, F Fatica, F Caternicchia, A I Lo Monte, M Cajozzo
AIM: The aim of this study is to assess, retrospectively, the incidence of secondary hypoparathyroidism after total thyroidectomy in patients with retrosternal goitre. MATERIAL AND METHODS: From January 2009 to September 2015, 622 patients who undergone total thyroidectomy for goitre, were retrospectively observed. The patients were divided into two group: Group A, including 58 patients with retrosternal goitre and Group B, including 562 patients with in situ goitre...
March 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29593805/evaluating-the-introduction-of-intraoperative-neuromonitoring-of-the-recurrent-laryngeal-nerve-in-thyroid-and-parathyroid-surgery
#19
Beata Wojtczak, Krzysztof Kaliszewski, Krzysztof Sutkowski, Mateusz Głód, Marcin Barczyński
Introduction: Paresis of the recurrent laryngeal nerve (RLN) is a complication of thyroid surgery. Neuromonitoring as is gaining acceptance among surgeons. The aim of the study was to assess the number of technical problems in the initial phase of intraoperative neuromonitoring (IONM) use and the specificity, sensitivity, positive predictive value and negative predictive value of neuromonitoring. The number of cases of postoperative paresis (transient and permanent) was assessed. Material and methods: The prospective analysis included 101 thyroid operations with IONM (190 RLNs at risk of injury) in the period from January to April, 2012...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29590494/endocrinopathies-and-renal-outcomes-in-lithium-therapy-impact-of-lithium-toxicity
#20
R Dineen, D Bogdanet, D Thompson, C J Thompson, L A Behan, A P McKay, G Boran, C Wall, J Gibney, V O'Keane, M Sherlock
Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects. Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Study design: A retrospective analysis was performed of the prevalence of lithium toxicity and renal, thyroid and parathyroid dysfunction in our study population...
December 1, 2017: QJM: Monthly Journal of the Association of Physicians
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