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https://www.readbyqxmd.com/read/29331775/experience-of-lecturers-with-simulation-training-in-midwifery-education-in-slovakia
#1
Erika Maskálová, Eva Urbanová, Martina Bašková, Eva Kvaltínyová
The simulation training in midwifery has a long tradition. It is aimed at acquiring basic and advanced practical skills such as performing a certain number of births, episiotomy and subsequent suture, assisting during breech birth etc. Midwifery education is currently based on the requirements of the Directives of the European Union exactly specifying number of performed practical procedures and approaches (World Health Organisation (WHO) Europe, 2009). The aim of this paper is to draw attention to the experience with the simulation training from the teacher's point of view in the study program Midwifery in Slovakia...
January 5, 2018: Midwifery
https://www.readbyqxmd.com/read/29327921/the-nature-and-reactivity-of-ferryl-heme-in-compounds-i-and-ii
#2
Peter C E Moody, Emma L Raven
Aerobic organisms have evolved to activate oxygen from the atmosphere, which allows them to catalyze the oxidation of different kinds of substrates. This activation of oxygen is achieved by a metal center (usually iron or copper) buried within a metalloprotein. In the case of iron-containing heme enzymes, the activation of oxygen is achieved by formation of transient iron-oxo (ferryl) intermediates; these intermediates are called Compound I and Compound II. The Compound I and II intermediates were first discovered in the 1930s in horseradish peroxidase, and it is now known that these same species are used across the family of heme enzymes, which include all of the peroxidases, the heme catalases, the P450s, cytochrome c oxidase, and NO synthase...
January 12, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29325569/the-relevance-of-clinical-ethnography-reflections-on-10%C3%A2-years-of-a-cultural-consultation-service
#3
Melissa Dominicé Dao, Sophie Inglin, Sarah Vilpert, Patricia Hudelson
BACKGROUND: Training health professionals in culturally sensitive medical interviewing has been widely promoted as a strategy for improving intercultural communication and for helping clinicians to consider patients' social and cultural contexts and improve patient outcomes. Clinical ethnography encourages clinicians to explore the patient's explanatory model of illness, recourse to traditional and alternative healing practices, healthcare expectations and social context, and to use this information to negotiate a mutually acceptable treatment plan...
January 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29324780/methods-for-sampling-geographically-mobile-female-traders-in-an-east-african-market-setting
#4
Aimee Leidich, Lillian Achiro, Zachary A Kwena, Willi McFarland, Torsten B Neilands, Craig R Cohen, Elizabeth A Bukusi, Carol S Camlin
BACKGROUND: The role of migration in the spread of HIV in sub-Saharan Africa is well-documented. Yet migration and HIV research have often focused on HIV risks to male migrants and their partners, or migrants overall, often failing to measure the risks to women via their direct involvement in migration. Inconsistent measures of mobility, gender biases in those measures, and limited data sources for sex-specific population-based estimates of mobility have contributed to a paucity of research on the HIV prevention and care needs of migrant and highly mobile women...
2018: PloS One
https://www.readbyqxmd.com/read/29323528/current-directions-in-laboratory-studies-of-personality-pathology-examples-from-borderline-personality-disorder-psychopathy-and-schizotypy
#5
Alexis K Matusiewicz, Katherine L McCauley, Julie M McCarthy, Nadia Bounoua, C W Lejuez
Much of the earliest research on personality pathology was observational and descriptive in nature, drawing heavily on subjective self-reports, however, the last 20 years have seen a surge of interest in laboratory-based studies. Laboratory research offers a number of benefits for researchers interested in personality disorders and personality pathology including the opportunities to use objective performance-based and behavioral measures, reveal the neuropsychological and biobehavioral processes that may help shape the experience and behavior of individuals with personality disorders, and create experimental designs that allow researchers to systematically explore the effect of context on emotional, behavioral and cognitive responding...
January 2018: Personality Disorders
https://www.readbyqxmd.com/read/29323436/molecular-characterization-and-gene-silencing-of-laccase-1-in-the-grain-aphid-sitobion-avenae
#6
Yong Zhang, Jia Fan, Frédéric Francis, Julian Chen
Laccase 1 (Lac1), a polyphenol oxidase, has been proposed to be involved in insect iron metabolism and immunity responses. However, little information is available on the roles of Lac 1 in insect-plant interactions. The grain aphid Sitobion avenae is one of the most destructive pests of cereal, directly drawing phloem sap and transmitting viruses. In the present study, we first cloned the open reading frame (ORF) of Lac 1 from S. avenae, and the putative protein sequence was predicted to have a carboxyl-terminal transmembrane domain...
January 11, 2018: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29314272/eruptive-nevi-under-tocilizumab-first-case-report-and-data-analysis
#7
Y Mansour, A Lambert, M Tebacher-Alt, J L Pasquali, D Lipsker
we would like to draw attention to an unusual side effect of tocilizumab (TOC), a humanized monoclonal antibody directed against the interleukin 6 (IL-6) receptor, approved for the treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29313911/spinal-cord-injury-arising-in-anaesthesia-practice
#8
REVIEW
D W Hewson, N M Bedforth, J G Hardman
Spinal cord injury arising during anaesthetic practice is a rare event, but one that carries a significant burden in terms of morbidity and mortality. In this article, we will review the pathophysiology of spinal cord injury. We will then discuss injuries relating to patient position, spinal cord hypoperfusion and neuraxial techniques. The most serious causes of spinal cord injury - vertebral canal haematoma, spinal epidural abscess, meningitis and adhesive arachnoiditis - will be discussed in turn. For each condition, we draw attention to practical, evidence-based measures clinicians can undertake to reduce their incidence, or mitigate their severity...
January 2018: Anaesthesia
https://www.readbyqxmd.com/read/29304784/ethical-aspects-of-diagnosis-and-interventions-for-children-with-fetal-alcohol-spectrum-disorder-fasd-and-their-families
#9
Gert Helgesson, Göran Bertilsson, Helena Domeij, Gunilla Fahlström, Emelie Heintz, Anders Hjern, Christina Nehlin Gordh, Viviann Nordin, Jenny Rangmar, Ann-Margret Rydell, Viveka Sundelin Wahlsten, Monica Hultcrantz
BACKGROUND: Fetal alcohol spectrum disorders (FASD) is an umbrella term covering several conditions for which alcohol consumption during pregnancy is taken to play a causal role. The benefit of individuals being identified with a condition within FASD remains controversial. The objective of the present study was to identify ethical aspects and consequences of diagnostics, interventions, and family support in relation to FASD. METHODS: Ethical aspects relating to diagnostics, interventions, and family support regarding FASD were compiled and discussed, drawing on a series of discussions with experts in the field, published literature, and medical ethicists...
January 5, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29297292/repositioning-drugs-by-targeting-network-modules-a-parkinson-s-disease-case-study
#10
Zongliang Yue, Itika Arora, Eric Y Zhang, Vincent Laufer, S Louis Bridges, Jake Y Chen
BACKGROUND: Much effort has been devoted to the discovery of specific mechanisms between drugs and single targets to date. However, as biological systems maintain homeostasis at the level of functional networks robustly controlling the internal environment, such networks commonly contain multiple redundant mechanisms designed to counteract loss or perturbation of a single member of the network. As such, investigation of therapeutics that target dysregulated pathways or processes, rather than single targets, may identify agents that function at a level of the biological organization more relevant to the pathology of complex diseases such as Parkinson's Disease (PD)...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29295847/how-i-use-catheter-directed-interventional-therapy-to-treat-patients-with-venous-thromboembolism
#11
Suresh Vedantham, Akhilesh K Sista
Patients who present with severe manifestations of acute venous thromboembolism (VTE) are at higher risk for premature death and long-term disability. In recent years, catheter-based interventional procedures have shown strong potential to improve clinical outcomes in selected VTE patients. However, physicians continue to be routinely faced with challenging decisions that pertain to the utilization of these risky and costly treatment strategies, and there is a relative paucity of published clinical trials with sufficient rigor and directness to inform clinical practice...
January 2, 2018: Blood
https://www.readbyqxmd.com/read/29288095/microparticles-microcapsules-and-microspheres-a-review-of-recent-developments-and-prospects-for-oral-delivery-of-insulin
#12
REVIEW
Chun Y Wong, Hani Al-Salami, Crispin R Dass
Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood sugar levels. However, subcutaneous injection of insulin can lead to patient non-compliance, discomfort, pain and local infection. Sub-micron sized drug delivery systems have gained attention in oral delivery of insulin for diabetes treatment. In most of the recent literature, the terms "microparticles" and "nanoparticle" refer to particles where the dimensions of the particle are measured in micrometers and nanometers respectively...
December 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29288084/comparison-of-in-vivo-and-ex-vivo-viscoelastic-behavior-of-the-spinal-cord
#13
Nicole L Ramo, Snehal S Shetye, Femke Streijger, Jae H T Lee, Kevin L Troyer, Brian K Kwon, Peter Cripton, Christian M Puttlitz
Despite efforts to simulate the in-vivo environment, post-mortem degradation and lack of blood perfusion complicate the use of ex-vivo derived material models in computational studies of spinal cord injury. In order to quantify the mechanical changes that manifest ex-vivo, the viscoelastic behavior of in-vivo and ex-vivo porcine spinal cord samples were compared. Stress-relaxation data from each condition were fit to a non-linear viscoelastic model using a novel characterization technique called the direct fit method...
December 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29286683/anisotropic-superattenuation-of-capillary-waves-on-driven-glass-interfaces
#14
Bruno Bresson, Coralie Brun, Xavier Buet, Yong Chen, Matteo Ciccotti, Jérôme Gâteau, Greg Jasion, Marco N Petrovich, Francesco Poletti, David J Richardson, Seyed Reza Sandoghchi, Gilles Tessier, Botond Tyukodi, Damien Vandembroucq
Metrological atomic force microscopy measurements are performed on the silica glass interfaces of photonic band-gap fibers and hollow capillaries. The freezing of attenuated out-of-equilibrium capillary waves during the drawing process is shown to result in a reduced surface roughness. The roughness attenuation with respect to the expected thermodynamical limit is determined to vary with the drawing stress following a power law. A striking anisotropic character of the height correlation is observed: glass surfaces thus retain a structural record of the direction of the flow to which the liquid was submitted...
December 8, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29284414/can-statistic-adjustment-of-or-minimize-the-potential-confounding-bias-for-meta-analysis-of-case-control-study-a-secondary-data-analysis
#15
Tianyi Liu, Xiaolu Nie, Zehao Wu, Ying Zhang, Guoshuang Feng, Siyu Cai, Yaqi Lv, Xiaoxia Peng
BACKGROUND: Different confounder adjustment strategies were used to estimate odds ratios (ORs) in case-control study, i.e. how many confounders original studies adjusted and what the variables are. This secondary data analysis is aimed to detect whether there are potential biases caused by difference of confounding factor adjustment strategies in case-control study, and whether such bias would impact the summary effect size of meta-analysis. METHODS: We included all meta-analyses that focused on the association between breast cancer and passive smoking among non-smoking women, as well as each original case-control studies included in these meta-analyses...
December 29, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29284230/new-directions-in-cervical-cancer-prophylaxis-worldwide-and-in-poland-case-study-of-the-polish-rural-female-population
#16
Agnieszka Maździarz, Jerzy Wyględowski, Beata Osuch, Beata Jagielska, Beata Śpiewankiewicz
INTRODUCTION: Cervical cancer is one of the most frequent malignant neoplasms in females. Such neoplasms can be almost completely eliminated by means of adequate primary and secondary prophylaxis. The most developed countries focus their attention on the improvement of prophylaxis systems, test quality, and efficacy improvement, as well as on the expansion of the primary prophylaxis. In Poland, the discussions focus on the improvement of the malfunctioning population programme. OBJECTIVE: Drawing on recent research findings, the article presents current Polish and global recommendations with regard to screening tests for cervical cancer...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29283070/pharmacogenomics-of-methotrexate-current-status-and-future-outlook
#17
Mengda Cao, Miao Guo, De-Qin Wu, Ling Meng
BACKGROUND: Methotrexate (MTX) is a folate analogue with high therapeutic efficiency in the treatment of cancers and autoimmune diseases. The efficacy and toxicity of MTX may be altered by genetic polymorphisms in genes involved in MTX metabolic pathway. Personalized pharmacotherapy based on gene polymorphisms enables a more efficient, compatible and cost-effective treatment of patients. OBJECTIVE: Present article aims to review genetic polymorphisms associated with MTX pharmacokinetics, toxicity, and outcome, and try to point out future development directions of individualized MTX therapy...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29283050/antibiotics-associated-disorders-and-postbiotics-induced-rescue-in-gut-health
#18
Debarati Paul, Sounik Manna, Santi M Mandal
The gut microbiota plays significant roles in the human body during all spheres' of life and influences innate immunity, promotes granulocyte signaling and provides resistance during pathogenic colonization of the gut; crucial for a healthy life. Antibiotics directly affect the gut microbiota that consequently alter the basic biological processes, and imposes severe consequences in population falling under different age groups. In this article, we have assessed the differences in microbial colonization and immune function of the intestinal tract in infants, adults, and the aged people and also have examined the recent reports describing the impacts of antibiotics on infant microbiome assembly and functioning...
December 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29282787/development-and-evaluation-of-the-expressions-of-moral-injury-scale-military-version
#19
Joseph M Currier, Jacob K Farnsworth, Kent D Drescher, Ryon C McDermott, Brook M Sims, David L Albright
There is consensus that military personnel can encounter a far more diverse set of challenges than researchers and clinicians have historically appreciated. Moral injury (MI) represents an emerging construct to capture behavioural, social, and spiritual suffering that may transcend and overlap with mental health diagnoses (e.g., post-traumatic stress disorder and major depressive disorder). The Expressions of Moral Injury Scale-Military Version (EMIS-M) was developed to provide a reliable and valid means for assessing the warning signs of a MI in military populations...
December 28, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29280434/surveillance-versus-ablation-for-incidentally-diagnosed-small-renal-tumours-the-surab-feasibility-rct
#20
Naeem Soomro, Jan Lecouturier, Deborah D Stocken, Jing Shen, Ann Marie Hynes, Holly F Ainsworth, David Breen, Grenville Oades, David Rix, Michael Aitchison
BACKGROUND: There is uncertainty around the appropriate management of small renal tumours. Treatments include partial nephrectomy, ablation and active surveillance. OBJECTIVES: To explore the feasibility of a randomised trial of ablation versus active surveillance. DESIGN: Two-stage feasibility study: stage 1 - clinician survey and co-design work; and stage 2 - randomised feasibility study with qualitative and economic components. METHODS: Stage 1 - survey of radiologists and urologists, and development of patient information materials...
December 2017: Health Technology Assessment: HTA
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