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https://www.readbyqxmd.com/read/28092101/the-cross-regulation-between-sox15-and-wnt-signaling-pathway
#1
REVIEW
Ali Moradi, Faezeh Ghasemi, Kazem Anvari, Seyed Mahdi Hassanian, Saeideh Ahmadi Simab, Safieh Ebrahimi, Amirreza Hesari, Mohammad Mahdi Forghanifard, Mohammad Taher Boroushaki, Soodabeh ShahidSales, Amir Avan
WNT/B-CATENIN signaling pathway is one of the key dysregulated pathways in different tumor types, which regulate the expression of several genes involved in cell proliferation, differentiation, and survival. This pathway is being modulated by sex-determining region Y-box (SOX) family genes. The functions of these genes are suggested as tumor suppressor or oncogene. SOX genes transcribe a group of transcription factors that play important roles in embryonic development and carcinogenesis. Among them, SOX15 is recently been identified as a novel tumor suppressor in pancreatic and esophagus cancers with a potential role in modulating Wnt/b-catenin signaling...
January 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28090074/targeting-of-wnt-%C3%AE-catenin-by-anthelmintic-drug-pyrvinium-enhances-sensitivity-of-ovarian-cancer-cells-to-chemotherapy
#2
Chongyuan Zhang, Zhenge Zhang, Shuirong Zhang, Wenrong Wang, Ping Hu
BACKGROUND Aberrant activation of Wnt/β-catenin has been shown to promote ovarian cancer proliferation and chemoresistance. Pyrvinium, an FDA-approved anthelmintic drug, has been identified as a potent Wnt inhibitor. Pyrvinium may sensitize ovarian cancer cells to chemotherapy. MATERIAL AND METHODS The effect of pyrvinium alone and its combination with paclitaxel in ovarian cancer was investigated using an in vitro culture system and in vivo xenograft models. The mechanisms of its action were also analyzed, focusing on the Wnt/β-catenin pathway...
January 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28077837/curcumin-inhibits-gastric-carcinoma-cell-growth-and-induces-apoptosis-by-suppressing-the-wnt-%C3%AE-catenin-signaling-pathway
#3
Ruzhen Zheng, Qinghua Deng, Yuehua Liu, Pengjun Zhao
BACKGROUND Curcumin has well-known, explicit biological anti-tumor properties. The Wnt/β-catenin signaling pathway plays a central role in tumor cell proliferation and curcumin can regulate the Wnt/b-catenin signaling pathway of several carcinomas. The aim of this study was to investigate the impact of curcumin on the Wnt/β-catenin signaling pathway in human gastric cancer cells. MATERIAL AND METHODS We used 3 gastric cancer cell lines: SNU-1, SNU-5, and AGS. Research methods used were MTT assay, flow cytometry, clonogenic assay, annexin V/PI method, Western blotting analysis, tumor formation assay, and in vivo in the TUNEL assay...
January 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28057768/tert-biology-and-function-in-cancer-beyond-immortalization
#4
Ana Pestana, João Vinagre, M Sobrinho-Simões, P Soares
Evasion of replicative senescence and proliferation without restriction, sometimes designated as immortalization, is one of cancer hallmarks that may be attained through reactivation of telomerase in somatic cells. In contrast to most normal cells in which there is lack of telomerase activity, upregulation of TERT transcription/activity is detected in 80 to 90% of malignant tumours. In several types of cancer there is a relationship between the presence of TERTp mutations, TERT mRNA expression and clinico-pathological features but the biological bridge between the occurrence of TERTp mutations and the aggressive/invasive features displayed by the tumours remains unidentified...
January 5, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28054306/circulating-dickkopf-1-and-sclerostin-in-patients-with-paget-s-disease-of-bone
#5
Luca Idolazzi, Angelo Fassio, Gaia Tripi, Vania Braga, Ombretta Viapiana, Giovanni Adami, Maurizio Rossini, Davide Gatti
Paget disease of bone is a chronic metabolic bone disorder characterized by increased bone resorption and new bone formation. The aim of this study is defining the role of inhibitors of canonical Wnt/b-catenin signaling pathway in patients with Paget disease of bone. Scarce and contrasting results have been reported in literature. We studied 40 patients (15 females and 25 males) with radiological and scintigraphic evidence of Paget disease of bone and 40 healthy subjects matched by age and sex. N-propeptide of type I collagen, C-terminal telopeptide of type I collagen, sclerostin, and Dickkopf-related protein 1 (DKK1) were evaluated by blood samples in our laboratory...
January 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/27984126/malignant-transformation-of-a-b-catenin-inflammatory-adenoma-due-to-a-s45-%C3%A3-catenin-activating-mutation-present-12-years-before
#6
Christine Sempoux, Bettina Bisig, Gabrielle Couchy, Charles Balabaud, Jessica Zucman-Rossi, Paulette Bioulac-Sage
In 1984, a 24-year-old woman underwent a right hepatectomy following a 17 cm nodule, diagnosed as a hepatocellular adenoma with some atypia. The resection was incomplete. Follow-up was interrupted. In 1996, a computed tomography scan revealed a large multifocal hepatocellular carcinoma (HCC) confirmed on biopsies. The patient died the same year. We reviewed these nodules using immunohistochemistry and gene sequencing. CRP was overexpressed in the tumor resected in 1984. Glutamine synthetase (GS) was heterogeneous in the tumor with few tumor nuclei expressing ß-catenin...
October 28, 2016: Human Pathology
https://www.readbyqxmd.com/read/27737536/long-non-coding-rna-hoxa11-antisense-promotes-cell-proliferation-and-invasion-and-predicts-patient-prognosis-in-serous-ovarian-cancer
#7
Ga Won Yim, Hee Jung Kim, Lee Kyung Kim, Sang Wun Kim, Sunghoon Kim, Eun Ji Nam, Young Tae Kim
Purpose: The biological function of long non-coding RNAs (lncRNAs) is only partially understood; therefore, in this study, we investigated the expression of the novel HOXA11 antisense (HOXA11as) lncRNA and its oncogenic role in serous ovarian cancer (SOC). Materials and Methods: HOXA11as expression was examined in 129 serous ovarian cancer tissue samples by real time RT-PCR. Clinicopathological factors and patient survival were compared between the high (N = 27) and low HOXA11as expression group (N = 102)...
October 11, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27733685/microvesicle-mediated-wnt-%C3%AE-catenin-signaling-promotes-interspecies-mammary-stem-progenitor-cell-growth
#8
Leen Bussche, Gat Rauner, Marc Antonyak, Bethany Syracuse, Melissa McDowell, Anthony M C Brown, Richard A Cerione, Gerlinde R Van de Walle
Signaling mechanisms that regulate mammary stem/progenitor cell (MaSC) self-renewal are essential for developmental changes that occur in the mammary gland during pregnancy, lactation, and involution. We observed that equine MaSCs (eMaSCs) maintain their growth potential in culture for an indefinite period, whereas canine MaSCs (cMaSCs) lose their growth potential in long term cultures. We then used this system to investigate the role of microvesicles (MVs) in promoting self-renewal properties. We found that Wnt3a and Wnt1 were expressed at higher levels in MVs isolated from eMaSCs compared with those from cMaSCs...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27715343/curcumin-reduces-lung-inflammation-via-wnt-%C3%AE-catenin-signaling-in-mouse-model-of-asthma
#9
Xia Yang, Jian-Ning Lv, Hui Li, Bo Jiao, Qiu-Hong Zhang, Yong Zhang, Jie Zhang, Yan-Qin Liu, Ming Zhang, Hu Shan, Jin-Zhao Zhang, Run-Miao Wu, Ya-Li Li
OBJECTIVES: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Curcumin has been found to have anti-inflammatory and antifibrosis effects. Researchers reported that curcumin regulated Wnt/β-catenin signaling in lots of cells. However, whether curcumin regulates the levels of Wnt/β-Catenin signaling in lung tissues and DCs (dendritic cells) remains unclear. In this study, we assessed the effects of curcumin on DCs and asthma...
August 15, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27706642/snail-induced-epithelial-mesenchymal-transition-in-gastric-carcinoma-cells-and-generation-of-cancer-stem-cell-characteristics
#10
Y J Yang, Z B Li, G R Zhang, L J Wu, J Y Yu, L J Hu, Y L Zhou, H D Wang, D Liang
Biological changes in Snail-overexpressed SGC7901 cells were studied by establishing a pEGFP-C1-Snail carrier. The significance of Snail in epithelial-mesenchymal transition (EMT) as well as the invasion and metastatic capacity of gastric cancer cells was also discussed; moreover, we attempted to verify the probable cancer stem cell characteristics of Snail-overexpressed cells. A pEGFP-C1-Snail eukaryotic expression plasmid was constructed and pEGFP-C1(-) and pEGFP-C1-Snail plasmids were extracted and transfected into SGC7901 cells using Lipofectamine 2000...
August 29, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27462123/cd133-positive-dermal-papilla-derived-wnt-ligands-regulate-postnatal-hair-growth
#11
Linli Zhou, Kun Yang, April Carpenter, Richard A Lang, Thomas Andl, Yuhang Zhang
Active Wnt/β-catenin signaling in the dermal papilla (DP) is required for postnatal hair cycling. In addition, maintenance of the hair-inducing ability of DP cells in vitro requires external addition of Wnt molecules. However, whether DP cells are a critical source of Wnt ligands and induce both autocrine and paracrine signaling cascades to promote adult hair follicle growth and regeneration remains elusive. To address this question, we generated an animal model that allows inducible ablation of Wntless (Wls), a transmembrane Wnt exporter protein, in CD133-positive (CD133+) DP cells...
October 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27402795/isoform-specific-function-of-calpains-in-cell-adhesion-disruption-studies-in-postlactational-mammary-gland-and-breast-cancer
#12
Lucía Rodríguez-Fernández, Iván Ferrer-Vicens, Concha García, Sara S Oltra, Rosa Zaragozá, Juan R Viña, Elena R García-Trevijano
Cleavage of adhesion proteins is the first step for physiological clearance of undesired cells during postlactational regression of the mammary gland, but also for cell migration in pathological states such as breast cancer. The intracellular Ca(2+)-dependent proteases, calpains (CAPNs), are known to cleave adhesion proteins. The isoform-specific function of CAPN1 and CAPN2 was explored and compared in two models of cell adhesion disruption: mice mammary gland during weaning-induced involution and breast cancer cell lines according to tumor subtype classification...
September 15, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27273957/e-cadherin-%C3%AE-catenin-deregulated-co-expression-in-thyroid-carcinoma-based-on-tissue-microarray-digital-image-analysis
#13
Evangelos Tsiambas, Vasileios Ragos, Georgios Georgakopoulos, Dimitrios N Rigopoulos, Panagiotis P Fotiades, Antonios Chatziioannidis, Athanasios Stamatelopoulos, Georgios Vilaras, Andreas Karameris
PURPOSE: Deregulation of cell-to-cell adhesion molecules is a common and also critical genetic event in epithelial malignancies leading to an increasing metastatic potential. Among them, e-cadherin and catenins--especially α and β--, act as oncogenes during the carcinogenetic process affecting specific signaling transduction pathways (i.e. Wnt/ b-catenin). Concerning thyroid carcinoma, decreased or loss of expression in these proteins seems to affect the biological behavior of the neoplasm increasing its aggressiveness...
March 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27122165/delamination-of-neural-crest-cells-requires-transient-and-reversible-wnt-inhibition-mediated-by-dact1-2
#14
M Angeles Rabadán, Antonio Herrera, Lucia Fanlo, Susana Usieto, Carlos Carmona-Fontaine, Elias H Barriga, Roberto Mayor, Sebastián Pons, Elisa Martí
Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal transition (EMT), a process that is influenced by Wnt/β-catenin signalling. Using two in vivo models, we show that Wnt/β-catenin signalling is transiently inhibited at the time of NC delamination. In attempting to define the mechanism underlying this inhibition, we found that the scaffold proteins Dact1 and Dact2, which are expressed in pre-migratory NC cells, are required for NC delamination in Xenopus and chick embryos, whereas they do not affect the motile properties of migratory NC cells...
June 15, 2016: Development
https://www.readbyqxmd.com/read/27090258/t-cell-factor-tcf-lef1-binding-elements-tbes-of-fasl-fas-ligand-or-cd95-ligand-bind-and-cluster-fas-cd95-and-form-complexes-with-the-tcf-4-and-b-catenin-transcription-factors-in-vitro-and-in-vivo-which-result-in-triggering-cell-death-and-or-cell-activation
#15
Xia Liu, Yuwei Huang, Yuanyuan Zhang, Xiaohong Li, Chun Liu, Shen Huang, Dezhi Xu, Yang Wu, Xiaojuan Liu
T-cell factor 4 (TCF4) is an important transcription factor of the Wnt signaling system. β-catenin, an upstream protein of TCF4, accumulates in the cytoplasm, then translocates to the nucleus to activate the β-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional machinery and regulates target genes. Previous studies showed that TCF4 was involved in cell proliferation and apoptosis. However, its expression and function in central nervous system injury are unclear. We performed a traumatic brain injury (TBI) model in adult rats...
August 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27067677/-genome-based-biomarkers-of-immune-checkpoint-blockade-therapy
#16
REVIEW
Keishi Adachi, Koji Tamada
Since 1981, cancer has been the leading cause of death in Japan, and its upward trend remains continuing until now. In 2013, approximately 365,000 Japanese died of cancer, and the ratio of the number of cancer-related deaths to the total number of deaths was 28.8%, implying that approximately 1 out of 3.5 deaths in Japan are caused by cancer. In recent years, immunotherapies are rapidly developed and recognized as an important anti-cancer treatment modality in addition to surgery, chemotherapy, and radiotherapy...
February 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27040799/prolidase-proline-dehydrogenase-proline-oxidase-collagen-biosynthesis-axis-as-a-potential-interface-of-apoptosis-autophagy
#17
REVIEW
Ilona Zareba, Jerzy Palka
Prolidase is a cytosolic imidodipeptidase that specifically splits imidodipeptides with C-terminal proline or hydroxyproline. The enzyme plays an important role in the recycling of proline from imidodipeptides for resynthesis of collagen and other proline-containing proteins. The mechanism of prolidase-dependent regulation of collagen biosynthesis was found at both transcriptional and post-transcriptional level. The increase in the enzyme activity is due to its phosphorylation on serine/threonine residues. Prolidase-dependent transcriptional regulation of collagen biosynthesis was found at the level of NF-κB, known inhibitor of type I collagen gene expression...
July 8, 2016: BioFactors
https://www.readbyqxmd.com/read/26943571/molecular-alterations-in-hepatocellular-carcinoma-associated-with-hepatitis-b-and-hepatitis-c-infections
#18
Maria Lina Tornesello, Luigi Buonaguro, Francesco Izzo, Franco M Buonaguro
Chronic infections with hepatitis B (HBV) and hepatitis C viruses (HCV) are the leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. Both viruses encode multifunctional regulatory proteins activating several oncogenic pathways, which induce accumulation of multiple genetic alterations in the infected hepatocytes. Gene mutations in HBV- and HCV-induced HCCs frequently impair the TP53, Wnt/b-catenin, RAS/RAF/MAPK kinase and AKT/mTOR pathways, which represent important anti-cancer targets. In this review, we highlight the molecular mechanisms underlying the pathogenesis of primary liver cancer, with particular emphasis on the host genetic variations identified by high-throughput technologies...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/26869487/3-3-5-triiodo-l-thyronine-increases-in-vitro-chondrogenesis-of-mesenchymal-stem-cells-from-human-umbilical-cord-stroma-through-src2
#19
Pablo Fernández-Pernas, Juan Fafián-Labora, Iván Lesende-Rodriguez, Jesús Mateos, Alexandre De la Fuente, Isaac Fuentes, Javier De Toro Santos, Fco Blanco García, María C Arufe
Our group focuses on the study of mesenchymal stem cells (MSCs) from human umbilical cord stroma or Warthońs jelly and their directed differentiation toward chondrocyte-like cells capable of regenerating damaged cartilage when transplanted into an injured joint. This study aimed to determine whether lactogenic hormone prolactin (PRL) or 3, 3', 5-triiodo-L-thyronine (T3), the active thyroid hormone, modulates chondrogenesis in our in vitro model of directed chondrogenic differentiation, and whether Wnt signalling is involved in this modulation...
September 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/26776161/oncogenic-carma1-couples-nf-%C3%AE%C2%BAb-and-%C3%AE-catenin-signaling-in-diffuse-large-b-cell-lymphomas
#20
M K Bognar, M Vincendeau, T Erdmann, T Seeholzer, M Grau, J R Linnemann, J Ruland, C H Scheel, P Lenz, G Ott, G Lenz, S M Hauck, D Krappmann
Constitutive activation of the antiapoptotic nuclear factor-κB (NF-κB) signaling pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphomas (DLBCL). Recurrent oncogenic mutations are found in the scaffold protein CARMA1 (CARD11) that connects B-cell receptor (BCR) signaling to the canonical NF-κB pathway. We asked how far additional downstream processes are activated and contribute to the oncogenic potential of DLBCL-derived CARMA1 mutants. To this end, we expressed oncogenic CARMA1 in the NF-κB negative DLBCL lymphoma cell line BJAB...
August 11, 2016: Oncogene
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