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Immunonutrition in cancer

Lucyna Scislo, Radoslaw Pach, Anna Nowak, Elzbieta Walewska, Malgorzata Gadek, Philip Brandt, Grazyna Puto, Antoni M Szczepanik, Jan Kulig
BACKGROUND: Immunomodulating enteral nutrition in the perioperative period may reduce postoperative complications in cancer patients. Little is known if this effect translates to the better survival. The aim of study was to assess the impact of postoperative immunomodulating enteral nutrition on postoperative complications and survival of gastric cancer patients. METHODS: A group of 98 gastric cancer patients was randomly assigned for postoperative immunomodulating enteral nutrition n = 44 (Reconvan, Fresenius Kabi, Bad Homburg, Germany), or standard enteral nutrition n = 54 (Peptisorb, Nutricia, Schipol, The Netherlands)...
March 13, 2018: Nutrition and Cancer
Nobuhiro Tsuchiya, Chikara Kunisaki, Hirochika Makino, Jun Kimura, Ryo Takagawa, Sho Sato, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Kentaro Sakamaki, Takeharu Yamanaka
PURPOSE: The present study evaluated the safety and effectiveness of laparoscopic gastrectomy (LG) in elderly gastric cancer patients. PATIENTS AND METHODS: This study included 78 gastric cancer patients aged 80 years or above [39 in the LG group and 39 in the open gastrectomy group (matched)]. Patient characteristics, surgical outcomes, survival time, and immunonutritional status were compared. RESULTS: Mean blood loss was significantly lower in the LG group, although the operation time did not differ...
March 7, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Jill M Hamilton-Reeves, Abigail Stanley, Misty D Bechtel, Thomas M Yankee, Prabhakar Chalise, Lauren K Hand, Eugene K Lee, Woodson Smelser, Moben Mirza, Hadley Wyre, Holly Hull, Susan E Carlson, Jeffrey M Holzbeierlein
PURPOSE: Poor preoperative nutritional status is associated with higher complication rates in bladder cancer patients after radical cystectomy (RC). Given the short lag time between diagnosis and RC, we compared a short-term Specialized IMmunonutrition (SIM) to a standard oral nutrition supplement (ONS) on the acute inflammatory response and arginine status in RC patients. MATERIALS AND METHODS: Twenty-nine men received SIM (n = 14) or ONS (n = 15) to drink three cartons/day for five days before and five days after RC in a prospective, randomized study...
March 5, 2018: Journal of Urology
Priscila Garla, Dan Linetzky Waitzberg, Alweyd Tesser
Malnutrition is the most frequent nutritional disorder in patients with gastrointestinal cancer and is associated with cachexia syndrome, worsening of prognosis, and shortened survival rate. Early nutrition screening, assessment, and intervention are able to favorably modify the clinical evolution of affected patients. The adequate provision of nutritional requirements has been associated with improvement of immunologic status, and avoidance of further complications related to poor nutritional status, surgical treatment, and anticancer therapy...
March 2018: Gastroenterology Clinics of North America
Ying Cheng, Junfeng Zhang, Liwei Zhang, Juan Wu, Zhen Zhan
BACKGROUND: Nutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. This meta-analysis aimed to assess the impact of EIN for patients with GC on biochemical, immune indices and clinical outcomes...
January 16, 2018: BMC Gastroenterology
Jing Xu, Xian Sun, Qianqian Xin, Ying Cheng, Zhen Zhan, Junfeng Zhang, Juan Wu
PURPOSE: Immunonutrition has been used to prevent the complications after colorectal elective surgery. This systematic review aimed to analyze and assess the effect of immunonutrition on colorectal cancer patients who received elective surgery. METHODS: Three electronic databases (Medline, Embase, Cochrane) were used to search the latent studies which investigated the effects of enteral immunonutrition (EIN) compared with standard enteral nutrition (EN) or parenteral immunonutrition (PIN) compared with standard parenteral nutrition (PN) on colorectal cancer patients who are undergoing surgery until 21st of April, 2017...
January 15, 2018: International Journal of Colorectal Disease
Yannick Cerantola
Postoperative morbidity remains a nightmare (although vivid), both for the patient and the surgeon. One phantasmagorical idea would be to give the patient a « magic potion » preoperatively aiming at eliminating the risk of postoperative complication. The purpose of the present review is to summarize the current knowledge on the potential benefits of immunonutrition administered to urological cancers patients. After a brief summary on the role of immunity in cancer surveillance and treatment, the rationale about administrating oral nutritional supplements able to modulate the patient's immune system before cystectomy for bladder cancer will be highlighted...
November 29, 2017: Revue Médicale Suisse
Kivanc Derya Peker, Sidika Seyma Ozkanli, Cebrail Akyuz, Orhan Uzun, Necdet Fatih Yasar, Mustafa Duman, Sinan Yol
Introduction: An increased number of tumor infiltrative lymphocytes (TILs) is considered a favorable prognostic factor in various cancers because it is a marker of antitumoral activity of the immune system. In this prospective, non-randomized clinical trial, we evaluated the impact of preoperative immunonutrition on tumor infiltrative lymphocytes and neoangiogenesis in cancerous tissue in patients with locoregional and resectable gastric adenocarcinoma. Material and methods: Patients with locoregional and resectable gastric adenocarcinoma were divided non-randomly into two study groups...
October 2017: Archives of Medical Science: AMS
Sheng Lu, Min Yan
The incidence of elderly gastric cancer patients is increasing, since the average life span is longer than ever before and the medical management is improved. Elderly patients usually have more comorbidities due to gradual loss of immunonutritional and functional status, leading to a higher rate of non-surgery-related postoperative morbidity and mortality. Along with the development of surgical and nursing technique, more and more surgeons would perform surgical procedures on elderly gastric cancer patients without hesitation...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Chang Liu, Lei Li, Wu-Sheng Lu, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Guo-Jun Zeng, Li Jiang, Jian Yang
For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NLR and PNI score was prognostically superior to either index alone in 793 patients with unresectable HCC after transarterial chemoembolization. Patient demographic, clinical, and pathological data were also collected and analysed...
October 24, 2017: Scientific Reports
Marco Scarpa, Andromachi Kotsafti, Matteo Fassan, Melania Scarpa, Francesco Cavallin, Teresa Nardi, Eleonora Pinto, Rita Alfieri, Matteo Cagol, Marco Agostini, Massimo Rugge, Ignazio Castagliuolo, Carlo Castoro
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal microenvironment of esophageal adenocarcinoma. Therefore, A prospective cohort of consecutive patients undergoing esophagectomy for esophageal adenocarcinoma was enrolled. A subgroup of them was given preoperative oral immunonutrition with Oral Impact® and was compared to those who received no preoperative supplementation...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Bahadır Osman Bozkırlı, Rıza Haldun Gündoğdu, Soner Akbaba, Turgay Sayın, Pamir Eren Ersoy
OBJECTIVE: Although many surgical patients face postoperative problems due to a poor nutritional status, there is evidence that many cases of malnutrition still go unnoticed and untreated in surgical wards. This study aims to define the current attitudes of surgeons toward nutritional screening and support. MATERIAL AND METHODS: A questionnaire with 13 questions was e-mailed to 1500 surgeons. Cross-queries were made over the responses. RESULTS: The response rate was 20...
2017: Turkish journal of surgery
Timothy D Lyon, Robert M Turner I I, Dawn McBride, Li Wang, Jeffrey R Gingrich, Ronald L Hrebinko, Bruce L Jacobs, Benjamin J Davies, Tatum V Tarin
INTRODUCTION: To investigate the use of a high-arginine immunonutrient supplement prior to radical cystectomy for bladder cancer. MATERIALS AND METHODS: We recruited 40 patients to consume a total of four high-arginine immunonutrient shakes per day for 5 days prior to radical cystectomy. The primary outcome measures were safety, tolerability and adherence to the supplementation regimen. Ninety-day postoperative outcomes were also compared between supplemented patients and a cohort of 104 prospectively identified non-supplemented radical cystectomy patients...
August 2017: Canadian Journal of Urology
Michel C Mocellin, Ricardo Fernandes, Thayz R Chagas, Erasmo B S M Trindade
BACKGROUND & AIMS: Chronic inflammation is related with cancer and leads to worsening prognosis in cancer patients. n-3 polyunsaturated fatty acids (PUFAs) supplementation has been proposed as adjuvant treatment in cancer due anti-inflammatory properties. In the present meta-analysis, we pooled randomized clinical trials (RCTs) assessing the effects of n-3 PUFAs (from fish oil isolated or added in an immunonutrition formula) on inflammatory markers in gastric cancer. METHODS: A comprehensive literature search was performed in Medline, Scopus, Cochrane library, Science Direct and Web of Science, besides GOOGLE Scholar and a hand searching of reference lists, through July 2016...
May 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Zhenzhen Luo, Junxia Wang, Zhen Zhang, Hong Li, Lan Huang, Yamin Qiao, Dan Wang, Jingjing Huang, Luwei Guo, Jinbo Liu, Yanhua Liu, Yi Zhang
BACKGROUND: Nutrition support is crucial for patients with gastrointestinal (GI) cancer after the operation. However, the controversy over the application of parenteral nutrition (PN) and early enteral immunonutrition (EEIN) has no determinate conclusion. MATERIALS AND METHODS: We compared the effects of PN and EEIN on the postoperative nutrition condition, immune status, inflammation level, long-term survival, and quality of life of the patients with GI cancer...
June 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
Chang-Bing Peng, Wen-Zhong Li, Rui Xu, Wen Zhuang
OBJECTIVES: To investigate the effects of early enteral immunonutrition on postoperative immune function and rehabilitation of gastric cancer patients with nutritional risk. METHODS: New hospitalized patients with gastric cancer were evaluated the nutrient status based on NRS 2002. The patients who scored between 3 to 5 points were randomized into two groups(30 cases for each group), and those in experimental group were given 7-d early postoperative enteral immune nutrition, those in control group were given normal nutrition...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Guo-Min Song, Xiao-Ling Liu, Wei Bian, Jing Wu, Yong-Hong Deng, Hui Zhang, Xu Tian
OBJECTIVES: Optimal enteral immunonutrition (EIN) regime for gastric cancer (GC) patients underwent gastrectomy remains uncertainty. To assess comparative efficacy of different EIN formulas in GC patients underwent gastrectomy, we performed network meta-analysis. RESULTS: We included 11 RCTs enrolling 840 patients. Pairwise meta-analysis indicated that EIN (RR 0.56, 95% CI 0.36-0.86; MD -0.42, 95% CI -0.74-0.10), Arg+RNA+ω-3-FAs (RR 0.37, 95% CI 0.22-0.63; MD -0...
April 4, 2017: Oncotarget
Conrad M Tobert, Jill M Hamilton-Reeves, Lyse A Norian, Chermaine Hung, Nathan A Brooks, Jeff M Holzbeierlein, Tracy M Downs, Douglas P Robertson, Ruth Grossman, Kenneth G Nepple
PURPOSE: Malnutrition is emerging as a significant factor in patient outcomes. A contemporary review of malnutrition has not been performed for the urologist. We review the available literature and current standards of care for malnutrition screening, assessment and intervention, focusing on patients with bladder cancer treated with cystectomy. MATERIALS AND METHODS: Our multidisciplinary team searched PubMed® for available literature on malnutrition, focusing on definition and significance, importance to urologists, screening, assessment, diagnosis, immunological and economic impacts, and interventions...
September 2017: Journal of Urology
Wen-Zhe Xu, Feng Li, Zhen-Kuan Xu, Xuan Chen, Bin Sun, Jing-Wei Cao, Yu-Guang Liu
OBJECTIVE: Impaired immunonutritional status has disadvantageous effects on outcomes for cancer patients. Preoperative albumin-to-globulin ratio (AGR) and the prognostic nutrition index (PNI) have been used as prognostic factors in various cancers. We aimed to evaluate the clinical significance of the AGR and PNI in glioblastoma. MATERIALS AND METHODS: This retrospective analysis involved 166 patients. Demographic, clinical, and laboratory data were collected. AGR and the PNI were calculated as AGR = albumin/(total serum protein - albumin) and PNI = albumin (g/L) + 5 × total lymphocyte count (10(9)/L)...
2017: OncoTargets and Therapy
R C G Martin, S Agle, M Schlegel, T Hayat, C R Scoggins, K M McMasters, P Philips
BACKGROUND: Improved preoperative immunonutrition has been shown to decrease the length of stay (LOS) and complications among patients undergoing elective gastrointestinal cancer surgeries. The purpose of this study was to determine whether preoperative immunonutrition supplementation decreases postoperative LOS, infectious complications, and morbidity in patients undergoing irreversible electroporation (IRE) surgery for locally advanced pancreatic cancer (LAPC). METHODS: At a regional hepatopancreatobiliary referral center within an academic medical center 71 patients receiving IRE treatment of LAPC were included in the study...
April 2017: European Journal of Surgical Oncology
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