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Immunonutrition in cancer

Hu Qiang, Lu Hang, Sun Y Shui
INTRODUCTION: It's uncertain about the clinical efficacy which early enteral immunonutrition in postoperative gastric cancer patients,and this study attempts to assess its clinical efficacy. EVIDENCE ACQUISITION: Use the search engine database incuding the Pubmed,the Cochrane library, Web of Science, Medline,and Embase,which there are comparative studies of early efficacy of enteral immune nutrition and standard enteral nutrition after gastric cancer operation.According to the studies,we use the RevMan 5...
December 1, 2016: Minerva Gastroenterologica e Dietologica
Selim Yiğit Yildiz, Murat Burç Yazicioğlu, Çağrı Tiryaki, Ali Çiftçi, Zehra Boyacioğlu
BACKGROUND/AIM: Enteral feeding and immunonutrition (ImN) have been shown to be associated with a number of favorable effects in patients undergoing cancer surgery. In this prospective study, we aimed to assess the perioperative use of enteral immunonutrition in patients undergoing radical gastrointestinal surgery for malignancy. MATERIALS AND METHODS: Forty-one patients with malignancy were included in this study and were randomized into one of the two following nutritional strategies: enteral only (EN) or enteral with enteral immunonutrition (ENIN)...
2016: Turkish Journal of Medical Sciences
Audrey Machado Dos Reis, Geórgia Brum Kabke, Ana Valéria Gonçalves Fruchtenicht, Taiane Dias Barreiro, Luis Fernando Moreira
INTRODUCTION: Costs, length of hospital staying and morbidity are frequently and significantly increased as a result of infections and other complications following surgical procedure for gastrointestinal tract cancer. Recently, improving host defence mechanisms have become a target of interest. Immunonutrition aims at improving immunity, most likely providing key nutrients to maintain T-lymphocyte and other host defence. AIM: To evaluate the immunonutrition in cancer patients who are operated by digestive diseases and assess the cost-effectiveness of this supplementation...
April 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Lin Yang, Liangping Xia, Yan Wang, Shaodong Hong, Haiyang Chen, Shaobo Liang, Peijian Peng, Yong Chen
BACKGROUND: Poor nutritional status is associated with progression and advanced disease in patients with cancer. The prognostic nutritional index (PNI) may represent a simple method of assessing host immunonutritional status. This study was designed to investigate the prognostic value of the PNI for distant metastasis-free survival (DMFS) in patients with nasopharyngeal carcinoma (NPC). METHODS: A training cohort of 1,168 patients with non-metastatic NPC from two institutions was retrospectively analyzed...
2016: PloS One
Fumihiro Shoji, Yosuke Morodomi, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Yuzo Suzuki, Takatoshi Fujishita, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: The most effective treatment for early-stage non-small cell lung cancer (NSCLC) is surgical resection. Nevertheless, up to 20% of patients, even those with stage I NSCLC, relapse after surgery and die. The prognostic nutritional index (PNI) is used to assess immunonutritional conditions or is a predictor of postoperative recurrence in patients with digestive malignancies. However, the usefulness of the PNI for lung cancer is still unknown. We retrospectively analyzed clinicopathological features of stage I NSCLC patients to identify predictors of recurrence and to investigate effects of preoperative PNI levels...
August 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Pedro Moya, Leticia Soriano-Irigaray, Jose Manuel Ramirez, Alessandro Garcea, Olga Blasco, Francisco Javier Blanco, Carlo Brugiotti, Elena Miranda, Antonio Arroyo
To compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the extent to which the combination of ERAS protocols and immunonutrition benefits patients undergoing colorectal cancer surgery is unknown...
May 2016: Medicine (Baltimore)
Josephine Gade, Trine Levring, Jens Hillingsø, Carsten Palnæs Hansen, Jens Rikardt Andersen
Major gastrointestinal surgery is associated with immune suppression and a high risk of postoperative complications. The aim of this open, randomized controlled trial was to examine the effect of supplementary per oral immunonutrition (IN) seven days before surgery for pancreatic cancer (PC) on postoperative complications and length of hospital stay (LOS). Secondary outcomes were the changes in functional capability and body weight (BW). Consecutive patients referred for surgery for diagnosed or plausible PC were included...
2016: Nutrition and Cancer
Pedro Moya, Elena Miranda, Leticia Soriano-Irigaray, Antonio Arroyo, Maria-Del-Mar Aguilar, Marta Bellón, Jose-Luis Muñoz, Fernando Candela, Rafael Calpena
OBJECTIVE: To determine whether the joint implementation of immunonutrition and a laparoscopic approach improves morbidity, mortality, and length of stay (LOS) compared with dietary advice. BACKGROUND: Despite progress in recent years in the surgical management of patients with colorectal cancer, postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the immunonutrition benefits in patients undergoing colorectal laparoscopic surgery are unknown...
March 2, 2016: Surgical Endoscopy
Nicholas R Rowan, Jonas T Johnson, Christina E Fratangelo, Brenda K Smith, Patricia A Kemerer, Robert L Ferris
OBJECTIVES: Investigate both the utility and feasibility of perioperative nutritional supplementation with an arginine-enriched immunonutrition formula to high-risk head and neck cancer surgical patients and examine its effects on acute post-operative clinical outcomes. MATERIALS & METHODS: This prospective, non-randomized, interventional cohort study compared high-risk head and neck cancer surgical patients who consumed a pre- and post-operative arginine-based nutritional supplement to those that did not...
March 2016: Oral Oncology
Elizabeth Pérez Cruz, Arturo Reyes Marín, Juan Asbun Bojalil, Jose Ignacio Arteaga Morfin
BACKGROUND: malnutrition is a common complication in patients with cancer and is associated with immunosuppression and alterations with inflammatory response. OBJECTIVE: the aim of our study was to evaluate the effect of enteral nutrition supplemented with two enteral formulas on inflammatory markers (CRP, IL-6 and FNTα) in cancer patients undergoing chemotherapy. DESIGN AND METHODS: randomized control trial, conducted at the Hospital Juarez of Mexico in patients with cancer undergoing chemotherapy with IRN < 97...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Raquel Escortell Sánchez, Manuel Reig García-Galbis
OBJECTIVE: to identify what effect causes enteral nutrition on nutritional status of cancer. METHOD: a search was performed using the keywords "Cancer" AND "Enteral Nutrition" AND "Supplementation" in four document databases: Pubmed, EBSCO, ProQuest, and Web of Science. INCLUSION CRITERIA: age of the sample, major than 18 years; submitted to surgery for cancer; that the intervention program was including diet and employment or not of nutritional Supplementation; clinical trials published between January 2004 and December 2014, in scientific journals indexed...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Bingna Cai, Hua Chen, Han Sun, Peng Wan, Huili Sun, Jianyu Pan
Chemotherapy is generally accompanied by undesirable side effects, such as immunosuppression and malnutrition, which reduce tolerance to cancer therapies. Prior studies have shown that immunonutrition improves the clinical outcomes of cancer patients. In this study, immunoregulatory polysaccharides from Crassostrea hongkongensis were included in a nutrition formula that was administered to S180 tumor-bearing mice in combination with 5-fluorouracil (5-FU) treatment. The C30-60% fraction of the polysaccharides was characterized as a branched polysaccharide, with a high amount of d-glucose (96...
January 2016: Food & Function
Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Kiyokazu Hiwatashi, Yota Kawasaki, Takaaki Arigami, Sumiya Ishigami, Yuko Kijima, Hiroyuki Shinchi, Sonshin Takao, Shoji Natsugoe
BACKGROUND: An association between inflammatory/immunonutritional status and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the utility of inflammatory/immunonutritional factors as therapeutic predictors for patients with locally advanced pancreatic cancer treated with chemoradiotherapy (CRT). METHODS: Ninety-six patients with histologically proven locally advanced pancreatic adenocarcinoma who underwent CRT were enrolled in this study...
November 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
C Mariette
Based on a grade A level of evidence, immunonutrition should be given to all patients operated on for a digestive cancer 5 to 7 days prior to surgery whatever could be the patient nutritional status. Immunonutrition should be continued in the postoperative phase in malnourished patients for 5 to 7 days or until patients are able to recover oral feeding covering at least 60% of their needs.
August 2015: Journal of Visceral Surgery
Guo-Min Song, Xu Tian, Hui Liang, Li-Juan Yi, Jian-Guo Zhou, Zi Zeng, Ting Shuai, Yang-Xiang Ou, Lei Zhang, Yan Wang
Gastric cancer (GC) is one of the most common upper gastrointestinal malignancies. Surgical resection remains the mainstay of curative treatment for GC. Enteral immunonutrition (EIN) has been increasingly used to enhance host immunity and relieve inflammatory response of patients undergoing surgery for GC; however, conclusions across studies still remain unclear. We aimed to evaluate the effects of EIN for such patients.We searched some electronic databases including PubMed, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE to identify any latent studies which investigated the effects of EIN compared with standard EN on GC patients who undergoing surgery until the end of December 30, 2014...
August 2015: Medicine (Baltimore)
Guo-Min Song, Xu Tian, Lei Zhang, Yang-Xiang Ou, Li-Juan Yi, Ting Shuai, Jian-Guo Zhou, Zi Zeng, Hong-Ling Yang
Enteral immunonutrition (EIN) has been established to be as a significantly important modality to prevent the postoperative infectious and noninfectious complications, enhance the immunity of host, and eventually improve the prognosis of gastrointestinal (GI) cancer patients undergoing surgery. However, different support routes, which are the optimum option, remain unclear. To evaluate the effects of different EIN support regimes for patients who underwent selective surgery for resectable GI malignancy, a Bayesian network meta-analysis (NMA) of randomized controlled trials (RCTs) was conducted...
July 2015: Medicine (Baltimore)
Patrice Forget, Garazi Echeverria, Simone Giglioli, Brigitte Bertrand, Stephane Nikis, Jean-Paul Lechat, Marc De Kock
BACKGROUND AND AIMS: Pre-existing malnutrition is one the most important factors affecting postsurgical complications, especially in cancer patients. The consequences of this on the immune function as well as on outcome could be reversed by immunonutrition. To help the clinician as a researcher, a routinely available biomarker (derived from clinical or biological data) would be of great importance. METHODS: We reviewed the potential markers that may routinely be used in perioperative immunonutrition programmes...
2015: Ecancermedicalscience
Kentaro Nakamura, Akina Sasayama, Takeshi Takahashi, Taketo Yamaji
Cancer cachexia is characterized by muscle wasting caused partly by systemic inflammation. We previously demonstrated an immune-modulating diet (IMD), an enteral diet enriched with immunonutrition and whey-hydrolyzed peptides, to have antiinflammatory effects in some experimental models. Here, we investigated whether the IMD in combination with chemotherapy could prevent cancer cachexia in colon 26 tumor-bearing mice. Forty tumor-bearing mice were randomized into 5 groups: tumor-bearing control (TB), low dose 5-fluorouracil (5-FU) and standard diet (LF/ST), low dose 5-FU and IMD (LF/IMD), high dose 5-FU and standard diet (HF/ST) and high dose 5-FU and IMD (HF/IMD)...
2015: Nutrition and Cancer
J Talvas, G Garrait, N Goncalves-Mendes, J Rouanet, J Vergnaud-Gauduchon, F Kwiatkowski, P Bachmann, C Bouteloup, J Bienvenu, M-P Vasson
BACKGROUND: Immunonutrition has been reported to improve the immune status of perioperative cancer patients, thereby reducing complications and length of hospital stay. AIM: This study aimed to assess whether immunonutrition enriched in arginine, EPA & DHA and nucleotides could impact the immune cells responses in head & neck and esophageal cancer patients treated by radiochemotherapy (RCT). METHODS: A double-blind clinical trial was carried out in 28 patients randomized into two groups, receiving either an immunomodulating enteral nutrition formula (IEN, n = 13, Impact(®), Nestlé) or an isoenergetic isonitrogenous standard enteral nutrition formula (SEN, n = 15) throughout RCT (5-7 weeks)...
October 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Oriana Ciacio, Thibault Voron, Gabriella Pittau, Maité Lewin, Eric Vibert, René Adam, Antonio Sa Cunha, Daniel Cherqui, Astrid Schielke, Olivier Soubrane, Olivier Scatton, Chady Salloum, Daniel Azoulay, Stéphane Benoist, Perrine Goyer, Jean-Christophe Vaillant, Laurent Hannoun, Emmanuel Boleslawski, Hélène Agostini, Didier Samuel, Denis Castaing
BACKGROUND: Malnutrition is an independent risk factor of postoperative morbidity and mortality and it's observed in 20 to 50% of surgical patients. Preoperative interventions to optimize the nutritional status, reduce postoperative complications and enteral nutrition has proven to be superior to the parenteral one. Moreover, regardless of the nutritional status of the patient, surgery impairs the immunological response, thus increasing the risk of postoperative sepsis. Immunonutrition has been developed to improve the immunometabolic host response in perioperative period and it has been proven to reduce significantly postoperative infectious complications and length of hospital stay in patients undergoing elective gastrointestinal surgery for tumors...
December 18, 2014: BMC Cancer
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