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https://www.readbyqxmd.com/read/29327153/the-effect-of-therapeutic-mild-hypothermia-on-brain-microvascular-endothelial-cells-during-ischemia-reperfusion-injury
#1
Yao Chen, Lin Wang, Yun Zhang, Yaxiong Zhou, Wei Wei, Zhi Wan
BACKGROUND: To determine the cerebral protective effects of mild hypothermia (MH) on cerebral microcirculation. METHODS: We established ischemia-reperfusion (I/R) injury and MH treatment models with rat brain microvascular endothelial cells (RBMECs) in vitro and examined the apoptotic changes. The cultured RBMECs were randomly divided into the control group, I/R group, and MH group, which was further divided into two subgroups: intra-ischemia hypothermia (IIH) and post-ischemia hypothermia (PIH)...
January 11, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29313398/a-15-year-review-of-secondary-and-tertiary-optic-nerve-sheath-fenestration-for-idiopathic-intracranial-hypertension
#2
Andrew J Anzeljc, Patrick Frias, Brent R Hayek, Nancy Canter Weiner, Ted H Wojno, H Joon Kim
PURPOSE: Optic nerve sheath fenestration (ONSF) is a common surgical option for patients with idiopathic intracranial hypertension (IIH) with vision loss refractory to medical management. Little is known about the visual benefit of repeated ONSF. The authors aimed to assess the efficacy of secondary and tertiary ONSF in patients with IIH. METHODS: A retrospective chart review was performed on all patients with repeat ONSF for IIH at Emory University from 1999 to 2016...
January 9, 2018: Orbit
https://www.readbyqxmd.com/read/29298687/segmentation-error-in-spectral-domain-optical-coherence-tomography-measures-of-the-retinal-nerve-fibre-layer-thickness-in-idiopathic-intracranial-hypertension
#3
Anuriti Aojula, Susan P Mollan, John Horsburgh, Andreas Yiangou, Kiera A Markey, James L Mitchell, William J Scotton, Pearse A Keane, Alexandra J Sinclair
BACKGROUND: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. METHODS: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29283154/idiopathic-intracranial-hypertension-associated-with-anaemia-secondary-to-antiretroviral-drug-in-a-human-immunodeficiency-virus-positive-patient
#4
J Vijay Ananth, S Sudharshan, Ambika Selvakumar, Bella J Devaleenal, Kavitha Kalaivani, Jyotirmay Biswas
Papilledema in a patient with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome is an alarming finding. Any condition giving rise to raised intracranial tension (ICT) can cause papilledema, and in these patients, it could be secondary to opportunistic infections like meningitis to neoplasm. We report a case of a 28-year old female with HIV on antiretroviral therapy, who presented to us, with papilledema. Her fundus examination revealed superficial hemorrhages and Roth's spots along with papilledema...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29258930/utility-of-intracranial-pressure-monitoring-for-diagnosis-of-idiopathic-intracranial-hypertension-in-the-absence-of-papilledema
#5
Kelly J Bridges, Ahmed M Raslan
BACKGROUND: Idiopathic intracranial hypertension (IIH) is characterized by headaches, visual obscurations, and papilledema, while diagnosis involves lumbar puncture (LP) with an elevated opening pressure (OP) ≥ 20cm H20. When papilledema is absent, diagnosis becomes less clear. Some physicians have argued that absence of papilledema rules out IIH, while others maintain that elevated OP is sufficient for diagnosis. METHODS: The authors performed a single institution 4-year retrospective analysis of patients who underwent invasive intracranial pressure (ICP) monitoring for presumed IIH...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29238388/what-do-transgender-patients-teach-us-about-idiopathic-intracranial-hypertension
#6
Catherine Hornby, Susan P Mollan, James Mitchell, Keira Annie Markey, Andreas Yangou, Ben L C Wright, Michael W O'Reilly, Alexandra J Sinclair
Idiopathic intracranial hypertension (IIH), a condition of raised intracranial pressure, is characterised by headaches and visual disturbances. Its pathogenesis is currently unknown; however, dysregulation of androgens may be implicated. Here, the authors present a case of a 22-year-old patient undergoing female-to-male (FTM) gender reassignment who developed IIH shortly after commencing testosterone therapy. This interesting case presents the possibility of androgens having a pathogenic role in IIH.
2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29194601/idiopathic-intracranial-hypertension-in-children-and-adolescents-an-update
#7
Catalina Cleves-Bayon
PREMISE: Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri syndrome (PTC) is a serious neurological disorder that can lead to irreversible visual loss. Predominantly a disorder affecting women in reproductive years, the pediatric population is not spared. PROBLEM: In the past few years, the condition has been redefined, due to new accepted values for opening pressure in children and advances in neuroimaging. Emerging techniques in ophthalmology are being increasingly used to monitor disease in these patients...
December 1, 2017: Headache
https://www.readbyqxmd.com/read/29192966/improving-identification-of-idiopathic-intracranial-hypertension-patients-in-swedish-patient-register
#8
A Sundholm, S Burkill, S Bahmanyar, A I M Nilsson Remahl
OBJECTIVE: Idiopathic intracranial hypertension (IIH) is often misdiagnosed. This can cause problems if conducting register-based studies. The study purpose was to produce algorithms that better identify patients with correct diagnosis of IIH in the Swedish National Patient Register (NPR). METHODS: Patients with ICD-10 code G93.2 for IIH registered in the NPR (2006-2013, Stockholm County) were included and diagnosis validated by medical record reviews. Patients were randomized into two groups: one used to produce the algorithm (n = 105) and one for validation (n = 102)...
November 28, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29175828/retrograde-3d-rotational-venography-3drv-for-venous-sinus-stent-placement-in-idiopathic-intracranial-hypertension
#9
Christopher C Young, Ryan P Morton, Basavaraj V Ghodke, Michael R Levitt
BACKGROUND: Dural venous sinus stenting has emerged as an effective and durable treatment for idiopathic intracranial hypertension (IIH). Improved visualization of the venous sinuses can improve stent placement. METHODS: We present two cases of IIH treated with venous sinus stenting in which retrograde three-dimensional rotational venography (3DRV) provided superior anatomical details of the venous sinuses for optimal sizing and positioning of stent. RESULTS: Comparison of pre-stent 3DRV with post-stent contrast-enhanced flat panel detector CT allowed confirmation of stent placement and the result of stenosis dilation...
November 24, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29165226/comparability-of-inflammation-adjusted-vitamin-a-deficiency-estimates-and-variance-in-retinol-explained-by-c-reactive-protein-and-%C3%AE-1-acid-glycoprotein-during-low-and-high-malaria-transmission-seasons-in-rural-zambian-children
#10
Maxwell A Barffour, Kerry J Schulze, Christian L Coles, Justin Chileshe, Ng'andwe Kalungwana, Margia Arguello, Ward Siamusantu, William J Moss, Keith P West, Amanda C Palmer
Inflammation-induced hyporetinolemia (IIH), a reduction in serum retinol (SR) during inflammation, may bias population estimates of vitamin A deficiency (VAD). The optimal adjustment for IIH depends on the type and extent of inflammation. In rural Zambian children (4-8 years, N = 886), we compared three models for defining inflammation: α-1-acid glycoprotein (AGP) only (inflammation present if > 1 g/L or normal if otherwise), C-reactive protein (CRP) only (moderate inflammation, 5-15 mg/L; high inflammation, > 15 mg/L; or normal if otherwise) and a combined model using both AGP and CRP to delineate stages of infectious episode...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29139045/electroretinography-in-idiopathic-intracranial-hypertension-comparison-of-the-pattern-erg-and-the-photopic-negative-response
#11
Jason C Park, Heather E Moss, J Jason McAnany
PURPOSE: To evaluate the relationship between electrophysiological measures of retinal ganglion cell (RGC) function in patients who have idiopathic intracranial hypertension (IIH). METHODS: The pattern electroretinogram (pERG) and photopic negative response (PhNR) were recorded from 11 IIH patients and 11 age-similar controls. The pERG was elicited by a contrast-reversing checkerboard. The PhNR, a slow negative component following the flash ERG b-wave, was recorded in response to a long-wavelength flash presented against a short-wavelength adapting field...
November 14, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29114973/internal-jugular-vein-stenosis-induced-intracranial-hypertension-can-be-resolved-by-stenting
#12
Da Zhou, Ran Meng, Xuxiang Zhang, Linlin Guo, Sijie Li, Weijuan Wu, Jiangang Duan, Haiqing Song, Yuchuan Ding, Xunming Ji
BACKGROUND: Idiopathic intracranial hypertension (IIH) is characterized by abnormally elevated intracranial pressure (ICP) without identifiable etiology. Recently, however, a subset of patients with presumed IIH have been found with isolated internal jugular vein (IJV) stenosis in the absence of intracranial abnormalities. METHODS: Fifteen consecutive patients were screened from 46 patients suspected as IIH and were finally confirmed as isolated IJV stenosis. The stenotic IJV was corrected with stenting when a trans-stenotic mean pressure gradient (∆MPG) was equal or higher than 5...
November 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29110769/impaired-cerebrospinal-fluid-pressure
#13
Jan Hoffmann
Abnormalities of cerebrospinal fluid (CSF) pressure are relatively common and may lead to a variety of symptoms, with headache usually being the most prominent one. The clinical presentation of alterations in CSF pressure may vary significantly and show a striking similitude to several primary headache syndromes. While an increase in CSF pressure may be of primary or secondary origin, a pathologic decrease of CSF pressure is usually the result of a meningeal rupture with a resulting leakage of CSF. The pathophysiologic mechanisms of idiopathic intracranial hypertension (IIH) remain largely unknown...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29095707/long-term-management-and-outcomes-after-repair-of-cerebrospinal-fluid-rhinorrhea-related-to-idiopathic-intracranial-hypertension
#14
Theodore A Schuman, Brent A Senior
PURPOSE OF REVIEW: To identify long-term management strategies and outcomes for the treatment of spontaneous cerebrospinal fluid (CSF) rhinorrhea related to idiopathic intracranial hypertension (IIH). RECENT FINDINGS: Adjuvant treatments following surgical repair of spontaneous CSF leaks are aimed at normalizing intracranial pressure (ICP) to minimize the risk of recurrence. IIH is closely linked to obesity, and growing evidence suggests that weight loss, both through conservative and surgical approaches, is effective at addressing the root cause of this disorder...
October 31, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29078127/radiculopathy-as-unusual-presentation-of-idiopathic-intracranial-hypertension-a-case-report
#15
Osama Ragab, Azza Ghali, Ayman Al-Malt, Shereen Al-Ahwal
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a disorder of young obese females and characterized by headache, papilledema with raised intracranial pressure in the absence of known pathological cause. However, ophthalmoplegia is common presentation of IIH, limb weakness is rare and may led to misdiagnosis and poor outcome. CASE: We report female patient presented with acute onset of quadriparesis, headache and ophthalmoplegia, the fundus examination showed papilledema, the MRI brain showed no detectable abnormal finding...
December 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29071043/migraine-headache-in-patients-with-idiopathic-intracranial-hypertension
#16
Farzad Sina, Saeed Razmeh, Neda Habibzadeh, Arefeh Zavari, Mona Nabovvati
Migraine is a neurological disorder that afflicts many people in the world and can cause severe disability during the attacks. The pathophysiology of migraine is complex and not fully understood. It seems that migraine is common in idiopathic intracranial hypertension (IIH). However, the association between migraine headache and IIH is still unclear. The present study was conducted to assess the prevalence of migraine headache and associated factors in IIH patients. In this cross-sectional study, a total of 68 patients diagnosed with IIH underwent a medical history interview and a neurological examination...
August 29, 2017: Neurology International
https://www.readbyqxmd.com/read/29055142/the-fate-of-the-bone-graft-in-cerebrospinal-fluid-rhinorrhea-endoscopic-repair-for-idiopathic-intracranial-hypertension-a-retrospective-case-series-analysis
#17
A D Workman, R M Carey, A K Parasher, E C Kuan, J Godovchik, J T Glicksman, D W Kennedy, J N Palmer, N D Adappa
INTRODUCTION: Idiopathic intracranial hypertension (IIH) is a common cause of spontaneous cerebrospinal fluid (CSF) leaks necessitating surgical intervention, and grafting of septal, mastoid, or turbinate bone over the defect is increasingly performed to strengthen the repair of the primary defect. However, the postoperative fate of these grafted bone fragments is largely unknown. METHODOLOGY: We performed a retrospective study of patients at the University of Pennsylvania undergoing repair of spontaneous CSF leaks secondary to IIH...
October 21, 2017: Rhinology
https://www.readbyqxmd.com/read/29026422/treatment-for-incarcerated-indirect-hernia-with-cross-internal-ring-inguinal-oblique-incision-in-children
#18
Xue-Qiang Yan, Jun Yang, Nan-Nan Zheng, Hou-Fang Kuang, Xu-Fei Duan, Hong-Qiang Bian
BACKGROUND: This study aims to evaluate the utility of the "Cross-Internal Ring" inguinal oblique incision for the surgical treatment of incarcerated indirect hernia (IIH) complicated with severe abdominal distension. MATERIALS AND METHODS: Patients of IIH complicated with severe abdominal distension were reviewed retrospectively. All patients received operation through the "Cross-Internal Ring" inguinal oblique incision. RESULTS: There were totally 13 patients were included, male to female ratio was 9-4...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29022960/idiopathic-intracranial-hypertension-in-a-pubertal-paediatric-indian-patient
#19
Anand Aggarwal, Prempal Kaur, Kanika Chhabra, Karamjit Singh, Piyush Goyal
BACKGROUND: Idiopathic Intracranial Hypertension (IIH) is characterised by raised intracranial pressure (ICP) with normal cerebrospinal fluid (CSF) composition and absence of hydrocephalus or space occupying lesions. IIH is a rare disease in children. It can lead to visual impairment but prompt diagnosis and treatment in most of the cases will prevent potentially permanent visual loss. OBJECTIVE: To report a rare case of Idiopathic Intracranial Hypertension in a pubertal child, clinical features, and findings of Magnetic Resonance Imaging (MRI) and visual field of this case...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29020632/activation-of-the-p53-transcriptional-program-sensitizes-cancer-cells-to-cdk7-inhibitors
#20
Sampada Kalan, Ramon Amat, Miriam Merzel Schachter, Nicholas Kwiatkowski, Brian J Abraham, Yanke Liang, Tinghu Zhang, Calla M Olson, Stéphane Larochelle, Richard A Young, Nathanael S Gray, Robert P Fisher
Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. However, whereas selective inhibition of analog-sensitive (AS) Cdk7 in colon cancer-derived cells arrests division and disrupts transcription, it does not by itself trigger apoptosis efficiently. Here, we show that p53 activation by 5-fluorouracil or nutlin-3 synergizes with a reversible Cdk7(as) inhibitor to induce cell death. Synthetic lethality was recapitulated with covalent inhibitors of wild-type Cdk7, THZ1, or the more selective YKL-1-116...
October 10, 2017: Cell Reports
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