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https://www.readbyqxmd.com/read/29780227/neurophysiologic-tests-screening-cognitive-impairment-in-idiopathic-intracranial-hypertension-patients
#1
Iman A Elbanhawy, Gihan M Ramzy, Mye A Basheer, Diana M Khedr
Background: Idiopathic intracranial hypertension (IIH) is a disorder with increased intracranial pressure of obscure cause. Patients with IIH may suffer from difficulty in thinking or concentrating. This work aimed at highlighting the neurophysiologic suggestions of cognitive impairment in IIH patients. Methods: Twenty patients with IIH-and a similar number of matched control subjects-were examined in this case-control study. The P300 and contingent negative variation (CNV) were performed...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29754068/contrast-enhanced-magnetic-resonance-venography-in-the-follow-up-evaluation-of-idiopathic-intracranial-hypertension-patients-with-cerebral-venous-sinus-stenting
#2
Srikanth R Boddu, Pierre Gobin, Cristiano Oliveira, Marc Dinkin, Athos Patsalides
PURPOSE: Role of contrast-enhanced magnetic resonance venography (CE-MRV) in the follow-up of venous sinus stenting (VSS) among the idiopathic intracranial hypertension (IIH) patients. MATERIALS AND METHODS: Prospective evaluation of VSS patients with CE-MRV, DRCV and DSA for follow-up of clinically suspected recurrent stenosis. CE-MRV was evaluated against DRCV and DSA. RESULTS: Ten patients with twelve episodes of recurrent symptoms. Sensitivity, specificity, PPV, NPV and accuracy of the CE-MRV for the detection of recurrent stenosis were: 100%, 33...
May 1, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29740393/comparison-of-ocular-ultrasonography-and-magnetic-resonance-imaging-for-detection-of-increased-intracranial-pressure
#3
David F Patterson, Mai-Lan Ho, Jacqueline A Leavitt, Nathan J Smischney, Sara E Hocker, Eelco F Wijdicks, David O Hodge, John Jing-Wei Chen
Background/aims: To evaluate and compare the performance of ocular ultrasonography (US) and magnetic resonance imaging (MRI) for detecting increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Methods: Twenty-two patients with papilledema from IIH and 22 with pseudopapilledema were prospectively recruited based on funduscopic and clinical findings. Measurements of optic nerve sheath diameters (ONSDs) 3 mm behind the inner sclera were performed on B-scan US and axial T2-weighted MRI examinations...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29736424/value-of-double-track-sign-in-differentiating-primary-from-thrombosed-transverse-sinus-stenosis-in-patients-presumed-to-have-idiopathic-intracranial-hypertension
#4
Nasser M Aldossary
Background: Idiopathic intracranial hypertension (IIH) is primarily a disorder of young obese women of unknown etiology. The clinical presentation of IIH is similar to that of sinus thrombosis. The incidence of transverse sinus stenosis (TSS) reaches up to 90% of patients with IIH compared with normal subjects, and venous sinus thrombosis was reported in 11.4% of patients previously diagnosed as having IIH. Patients with thrombosis showed an abnormal region of double- track pattern on gadolinium (Gd) - enhanced T1WI within the dural sinus...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29721718/an-up-to-date-review-of-pseudotumor-cerebri-syndrome
#5
REVIEW
John Glenn Burkett, Jessica Ailani
PURPOSE OF REVIEW: Idiopathic intracranial hypertension (IIH), pseudotumor cerebri syndrome (PTCS), and benign intracranial hypertension are all terms that have been used for a neurologic syndrome consisting of elevated intracranial pressure (ICP), headache and vision loss without mass lesion or underlying infection or malignancy. In this review article, categorization, diagnostic criteria, symptom management strategies, and disease treatment options for pseudotumor cerebri syndrome will be discussed...
May 2, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29619550/perspectives-on-diagnosis-and-management-of-adult-idiopathic-intracranial-hypertension
#6
Irini Chatziralli, Panagiotis Theodossiadis, George Theodossiadis, Ioannis Asproudis
PURPOSE: The purpose of this review is to shed light into the diagnostic challenges regarding idiopathic intracranial hypertension (IIH), giving more emphasis to the role of optical coherence tomography (OCT) in IIH, while it also presents recent advances in the management of IIH. METHODS: A literature search in PubMed was performed for studies about the diagnosis and management of IIH published before June 30, 2017. Then, a comprehensive review of the eligible studies and the relevant references was performed...
April 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29608535/genetic-survey-of-adult-onset-idiopathic-intracranial-hypertension
#7
Markus H Kuehn, Rajashree Mishra, Benjamin E Deonovic, Kimberly N Miller, Shana E McCormack, Grant T Liu, Mark J Kupersmith, Michael Wall
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure of unknown cause. IIH has been shown to be associated with female sex as well as obesity. This genome-wide association study was performed to determine whether genetic variants are associated with this condition. METHODS: We analyzed the chromosomal DNA of 95 patients with IIH enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and 95 controls matched on sex, body mass index, and self-reported ethnicity...
March 30, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29574006/a-rapid-screening-of-a-recurrent-cyp24a1-pathogenic-variant-opens-the-way-to-molecular-testing-for-idiopathic-infantile-hypercalcemia-iih
#8
Elisa De Paolis, Angelo Minucci, Maria De Bonis, Giovanni Luca Scaglione, Jacopo Gervasoni, Aniello Primiano, Pietro Manuel Ferraro, Daniele Cappellani, Claudio Marcocci, Giovanni Gambaro, Ettore Capoluongo
INTRODUCTION: Loss-of-function mutations in cytochrome P450 family 24 subfamily A member 1 (CYP24A1) gene are associated with Idiopathic Infantile Hypercalcemia (IIH) and adult kidney stone disease. The enzyme deficiency leads to an impaired vitamin D catabolism pathway, resulting in a syndrome characterized by recurrent hypercalcemia, hypercalciuria and suppressed parathyroid hormone (PTH) levels. In these patients, the genetic evaluation of CYP24A1 is an important diagnostic tool, allowing the definitive diagnosis of IIH...
March 21, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29565728/optic-nerve-sheath-fenestration-a-revised-lateral-approach-for-nerve-access
#9
Nathan W Blessing, David T Tse
Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, describes a disease of poorly understood pathophysiology with a specific set of signs and symptoms including potentially irreversible and blinding visual loss. Optic nerve sheath fenestration (ONSF) is a well-described surgical treatment for patients with IIH and progressive visual loss despite maximally tolerated medical therapy. A number of optic nerve access procedures have been described including medial transconjunctival, superomedial lid crease, and lateral orbitotomy with and without bone takedown...
March 22, 2018: Orbit
https://www.readbyqxmd.com/read/29563954/evaluating-the-fat-distribution-in-idiopathic-intracranial-hypertension-using-dual-energy-x-ray-absorptiometry-scanning
#10
Catherine Hornby, Hannah Botfield, Michael W O'Reilly, Connar Westgate, James Mitchell, Susan P Mollan, Konstantinos Manolopoulos, Jeremy Tomlinson, Alexandra Sinclair
Idiopathic intracranial hypertension (IIH) is strongly associated with obesity. We aimed to utilise dual-energy X-ray absorptiometry (DEXA) to characterise fat distribution, and to evaluate change in fat mass and distribution following weight loss. IIH patients ( n = 24) had a similar fat distribution to body mass index (BMI)- and gender-matched obese controls ( n = 47). In the IIH cohort, truncal fat mass correlated with lumbar puncture pressure. Weight loss in IIH patients resulted in a significant reduction in disease activity and fat mass, predominantly from the truncal region (-4...
April 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29563950/the-melanopsin-mediated-pupillary-light-response-is-not-changed-in-patients-with-newly-diagnosed-idiopathic-intracranial-hypertension
#11
Shakoor Ba-Ali, Rigmor Højland Jensen, Line Sofie Larsen, Henrik Lund-Andersen, Steffen Hamann
Previously, it has been reported that melanopsin-mediated pupillary light response (PLR), measured with pupillometry, is reduced in patients with idiopathic intracranial hypertension (IIH), indicating the clinical utility of the tool in the diagnosis of IIH. In the current study, the authors aimed to measure the PLR in 13 treatment-naive patients with new-onset IIH and 13 healthy controls. In contrast to the previous report, which was based on patients with longstanding IIH ( n = 13), the authors found no significant difference in the melanopsin-mediated PLR ( p = 0...
April 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29563210/venous-waveform-morphological-changes-associated-with-treatment-of-symptomatic-venous-sinus-stenosis
#12
James L West, Rebecca M Garner, Garret P Greeneway, Justin R Traunero, Carol A Aschenbrenner, Jasmeet Singh, Stacey Q Wolfe, Kyle M Fargen
INTRODUCTION: Venous outflow obstruction is recognized as a contributing factor in a subset of patients with idiopathic intracranial hypertension (IIH). Little is known about venous sinus waveform morphology or how it changes after stenting. METHODS: Fifteen patients with IIH underwent waveform recording during catheter venography and manometry. Ten patients (Group A) with venous sinus stenosis and pressure gradient ≥7 mm Hg underwent waveform recording during awake venography and during stenting under general anesthesia...
March 21, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29554002/cerebrospinal-fluid-pressure-reduction-results-in-dynamic-changes-in-optic-nerve-angle-on-magnetic-resonance-imaging
#13
Ranliang Hu, John Holbrook, Nancy J Newman, Valerie Biousse, Beau B Bruce, Deqiang Qiu, John Oshinski, Amit M Saindane
BACKGROUND: Optic nerve sheath tortuosity is a previously reported, but incompletely characterized, finding in idiopathic intracranial hypertension (IIH). We hypothesized that optic nerve angle (ONA), as a quantitative measure of tortuosity, would change dynamically with cerebrospinal fluid (CSF) pressure status of patients with IIH immediately before and after lumbar puncture (LP). METHODS: Consecutive patients with suspected IIH referred for MRI and diagnostic LP were prospectively enrolled in this single institution, institutional review board-approved study...
March 16, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29538049/the-importance-of-specific-rehabilitation-for-an-obese-patient-with-idiopathic-intracranial-hypertension-a-case-report
#14
Alberto Raggi, Licia Grazzi, Stefania Bianchi Marzoli, Paola Ciasca, Luisa Chiapparini, Alessandra Erbetta, Giuseppe Faragò, Matilde Leonardi, Domenico D'Amico
Idiopathic intracranial hypertension (IIH) is associated with obesity, and weight loss is important to reduce intracranial pressure and improve visual function. A 38-year-old woman with IIH followed an extreme diet, which resulted in 30% weight loss (BMI moved from 34.9 to 24.6). Weight loss resulted in a significant reduction of papilloedema, normalization of intracranial pressure and improvement in headache pattern, but also induced a state of initial malnutrition, relevant depression and disability. She was discharged with the indication to start a controlled diet and improve physical activity: clinical situation get back to stability, with the patient loosing further weight (BMI=21...
June 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29534973/lateral-but-not-medial-hypothalamic-ampk-activation-occurs-at-the-hypoglycemic-nadir-in-insulin-injected-male-rats-impact-of-caudal-dorsomedial-hindbrain-catecholamine-signaling
#15
Hussain N Alhamami, Md Main Uddin, A S M Hasan Mahmood, Karen P Briski
The hypothalamic energy sensor adenosine 5'-monophosphate-activated protein kinase (AMPK), an important regulator of counter-regulatory responses to hypoglycemia, responds to pharmacological manipulation of hindbrain AMPK activity. Dorsomedial hindbrain A2 noradrenergic neurons express hypoglycemia-sensitive metabolo-sensory biomarkers, including AMPK. Here, adult male rats were pretreated by intra-caudal fourth ventricular administration of the selective neurotoxin 6-hydroxydopamine (6-OHDA) to determine if catecholamine signaling from the aforesaid site governs hypothalamic AMPK activation during insulin-induced hypoglycemia (IIH)...
May 21, 2018: Neuroscience
https://www.readbyqxmd.com/read/29532475/intracranial-pressure-in-patients-with-papilloedema
#16
J P Funnell, C L Craven, L D'Antona, S D Thompson, A Chari, L Thorne, L D Watkins, A K Toma
OBJECTIVES: Papilloedema is a clinical manifestation of chronically raised intracranial pressure (ICP), often seen in idiopathic intracranial hypertension (IIH). However, the extent of intracranial hypertension required to produce papilloedema is not known. We compare ICP values in IIH patients who developed papilloedema and those who did not. We aim to identify a pathological ICP threshold predictive of the development of papilloedema in IIH patients. MATERIALS AND METHODS: Single-centre cohort of IIH patients (2006-2016) who underwent 24-hour ICP monitoring (ICPM) and ophthalmology assessments, prior to intervention...
March 12, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29498569/fifty-shades-of-gradients-does-the-pressure-gradient-in-venous-sinus-stenting-for-idiopathic-intracranial-hypertension-matter-a-systematic-review
#17
Cameron M McDougall, Vin Shen Ban, Jeffrey Beecher, Lee Pride, Babu G Welch
OBJECTIVE The role of venous sinus stenting (VSS) for idiopathic intracranial hypertension (IIH) is not well understood. The aim of this systematic review is to attempt to identify subsets of patients with IIH who will benefit from VSS based on the pressure gradients of their venous sinus stenosis. METHODS MEDLINE/PubMed was searched for studies reporting venous pressure gradients across the stenotic segment of the venous sinus, pre- and post-stent pressure gradients, and clinical outcomes after VSS. Findings are reported according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
March 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29492568/cerebrospinal-fluid-and-cerebral-blood-flows-in-idiopathic-intracranial-hypertension
#18
Cyrille Capel, Marc Baroncini, Catherine Gondry-Jouet, Roger Bouzerar, Marek Czosnyka, Zofia Czosnyka, Olivier Balédent
OBJECTIVES: Cerebrospinal fluid (CSF) and blood flows have a strong relationship during a cardiac cycle. Idiopathic intracranial hypertension (IIH) is a pathology that seems to present hemodynamic and hydrodynamic disturbance. The aim of this study was to establish CSF and blood interaction in IIH. MATERIAL AND METHODS: We retrospectively studied cerebral hydrodynamic and hemodynamic flows by phase-contrast MRI (PCMRI) in 13 IIH subjects (according Dandy's criteria) and 16 controls...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29477544/cerebral-microvascular-abnormalities-in-patients-with-idiopathic-intracranial-hypertension
#19
Vigdis Andersen Eidsvaag, Hans-Arne Hansson, Kjell Heuser, Erlend A Nagelhus, Per Kristian Eide
AIM: Idiopathic intracranial hypertension (IIH) is characterized by symptoms indicative of increased intracranial pressure (ICP), such as headache and visual impairment. We have previously reported that brain biopsies from IIH patients show patchy astrogliosis and increased expression of the water channel aquaporin-4 (AQP4) at perivascular astrocytic endfeet. METHODS: The present study was undertaken to investigate for ultrastructural changes of the cerebral capillaries in individuals with IIH...
May 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29455905/ventriculoperitoneal-shunt-treatment-in-a-pregnant-renal-transplant-recipient-with-idiopathic-intracranial-hypertension-case-report-and-review-of-the-literature
#20
Ebru Apaydın Doğan, Selen Doğan, Ethem Taner Göksu, Sibel Özkaynak, Çile Aktan, İnanç Mendilcioğlu
Idiopathic intracranial hypertension (IIH) is a relatively uncommon disorder characterised by raised intracranial pressure without an established pathogenesis. Diagnosis of IIH requires the demonstration of symptoms and signs referable only to elevated intracranial pressure; cerebrospinal fluid (CSF) opening pressure >25cm H2 O measured in the lateral decubitus position; normal CSF composition; and no evidence for an underlying structural cause demonstrated by using MRI or contrast-enhanced CT scan for typical patients and MRI and MR venography for atypical patients such as man, children and those with low body mass index...
February 6, 2018: Neurologia i Neurochirurgia Polska
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