keyword
https://read.qxmd.com/read/38495891/construction-of-an-aerolysin-based-multi-epitope-vaccine-against-aeromonas-hydrophila-an-in-silico-machine-learning-and-artificial-intelligence-supported-approach
#1
JOURNAL ARTICLE
Abdullah S Alawam, Maher S Alwethaynani
Aeromonas hydrophila , a gram-negative coccobacillus bacterium, can cause various infections in humans, including septic arthritis, diarrhea (traveler's diarrhea), gastroenteritis, skin and wound infections, meningitis, fulminating septicemia, enterocolitis, peritonitis, and endocarditis. It frequently occurs in aquatic environments and readily contacts humans, leading to high infection rates. This bacterium has exhibited resistance to numerous commercial antibiotics, and no vaccine has yet been developed. Aiming to combat the alarmingly high infection rate, this study utilizes in silico techniques to design a multi-epitope vaccine (MEV) candidate against this bacterium based on its aerolysin toxin, which is the most toxic and highly conserved virulence factor among the Aeromonas species...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38492825/acanthopanax-senticosus-cultures-fermented-by-lactobacillus-rhamnosus-enhanced-immune-response-through-improvement-of-antioxidant-activity-and-inflammation-in-crucian-carp-carassius-auratus
#2
JOURNAL ARTICLE
Yi-Han Ma, Yu-Di Sheng, Di Zhang, Jun-Tong Liu, Ye Tian, Hui Li, Xiao-Fei Li, Na Li, Peng Sun, Shahrood Ahmed Siddiqui, Wu-Wen Sun, Lei Zhang, Xiao-Feng Shan, Chun-Feng Wang, Ai-Dong Qian, Dong-Xing Zhang
Lactic acid bacteria (LAB) have been recognized as safe microorganism that improve micro-flora disturbances and enhance immune response. A well-know traditional herbal medicine, Acanthopanax senticosus (As) was extensively utilized in aquaculture to improve growth performance and disease resistance. Particularly, the septicemia, skin wound and gastroenteritis caused by Aeromonas hydrophila threaten the health of aquatic animals and human. However, the effects of probiotic fermented with A. senticosus product on the immune regulation and pathogen prevention in fish remain unclear...
March 14, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38481095/expression-of-immuno-transcriptome-response-in-red-hybrid-tilapia-oreochromis-sp-hindgut-following-vaccination-with-feed-based-bivalent-vaccine
#3
JOURNAL ARTICLE
Nur Shidaa Mohd Ali, Mohamad Syazwan Ngalimat, Mohd Zamri Saad, Mohammad Noor Amal Azmai, Annas Salleh, Zarirah Zulperi, Ina Salwany Md Yasin
Streptococcosis and aeromoniasis are the main obstacles to sustainable tilapia production. Vaccination offered an effective method to control microbial infections. Previously, a feed-based bivalent vaccine (FBBV) containing killed whole organisms of Streptococcus agalactiae and Aeromonas hydrophila mixed with 10% palm oil was successfully developed, which provided good protection against streptococcosis and aeromoniasis in Oreochromis sp. However, the mechanisms of immunities in vaccinated fish still need clarification...
March 13, 2024: Journal of Fish Diseases
https://read.qxmd.com/read/38459543/phenotypic-molecular-detection-and-antibiotic-resistance-profile-mdr-and-xdr-of-aeromonas-hydrophila%C3%A2-isolated-from-farmed-tilapia-zillii-and-mugil-cephalus
#4
JOURNAL ARTICLE
Hala F Ayoub, Ahmed R Khafagy, Aboelkair M Esawy, Noura Abo El-Moaty, Khairiah Mubarak Alwutayd, Abdallah Tageldein Mansour, Reham A Ibrahim, Dalia A Abdel-Moneam, Reham M El-Tarabili
In the present study, Aeromonas hydrophila was isolated from Tilapia zillii and Mugil cephalus samples collected during different seasons from various Suez Canal areas in Egypt. The prevalence of A. hydrophila, virulence genes, and antibiotic resistance profile of the isolates to the commonly used antibiotics in aquaculture were investigated to identify multiple drug resistance (MDR) and extensive drug-resistant (XDR) strains. In addition, a pathogenicity test was conducted using A. hydrophila, which was isolated and selected based on the prevalence of virulence and resistance genes, and morbidity of natural infected fish...
March 8, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38441470/the-impact-of-lactococcus-lactis-kust48-on-the-transcription-profile-of-aeromonas-hydrophila-infected-zebrafish-spleen
#5
JOURNAL ARTICLE
Jiayu Chen, Qiuyue Li, Lili Fan, Liqin Xie, Qilin Zhang, Xianyu Deng
Aeromonas hydrophila , an aquatic pathogenic bacterium, has been found to infect many fish species and cause huge aquaculture losses. Antibiotics are the most common drugs used to treat these infections. However, antibiotic abuse can lead to the development of antibiotic resistance. Probiotics have the potential to replace antibiotics for preventing infections. Zebrafish ( Danio rerio ) is a model organism used to study the innate immune system and host-pathogen interactions. Currently, there is little information on how the fish immune system responds to A...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38433212/emergence-and-clonal-expansion-of-aeromonas-hydrophila-st1172-that-simultaneously-produces-mox-13-and-oxa-724
#6
JOURNAL ARTICLE
Xinfei Chen, Minya Lu, Yao Wang, Han Zhang, Xinmiao Jia, Peiyao Jia, Wenhang Yang, Jiawei Chen, Guobin Song, Jianguo Zhang, Yingchun Xu
BACKGROUND: Aeromonas hydrophila infections can cause gastrointestinal symptoms such as diarrhea; however, deep infections are rarely reported. Outbreaks of A. hydrophila are reported more frequently in fish, poultry, and snakes than in humans. This study aimed to track clonal relatedness of deep infections caused by A. hydrophila using whole genome sequencing (WGS). METHODS: We collected three isolates of A. hydrophila in July 19 to August 29, 2019, from patients that underwent spine surgery...
March 3, 2024: Antimicrobial Resistance and Infection Control
https://read.qxmd.com/read/38427282/dietary-intakes-of-vitamin-d-promote-growth-performance-and-disease-resistance-in-juvenile-grass-carp-ctenopharyngodon-idella
#7
JOURNAL ARTICLE
Yueyue Wang, Jiaxi Liu, Haoran Xiao, Hao Sun, Hengyi Hu, Xiaoyu Ma, Anying Zhang, Hong Zhou
Vitamin D3 (VD3 ) is an essential nutrient for fish and participates in a variety of physiological activities. Notably, both insufficient and excessive supplementation of VD3 severely impede fish growth, and the requirements of VD3 for fish vary considerably in different species and growth periods. The present study aimed to evaluate the appropriate requirements of VD3 for juvenile grass carp (Ctenopharyngodon idella) according to growth performance and disease prevention capacity. In this study, diets containing six supplemental levels of VD3 (0, 300, 600, 1200, 2400, and 4800 IU/kg diet) were formulated to investigate the effect(s) of VD3 on the growth performance, antioxidant enzyme activities, and antimicrobial ability in juvenile grass carp...
March 1, 2024: Fish Physiology and Biochemistry
https://read.qxmd.com/read/38417143/one-pot-synthesis-of-useful-s-substituted-l-cysteine-sulfoxides-using-genetically-engineered-escherichia-coli
#8
JOURNAL ARTICLE
Taku Mizutani, Ryotaro Hara, Michiki Takeuchi, Makoto Hibi, Makoto Ueda, Jun Ogawa
S-Substituted-l-cysteine sulfoxides are valuable compounds that are contained in plants. Particularly, (+)-alliin and its degraded products have gained significant attention because of their human health benefits. However, (+)-alliin production has been limited to extraction from plants and chemical synthesis; both methods have drawbacks in terms of stability and safety. Here, we proposed the enzymatic cascade reaction for synthesizing (+)-alliin from readily available substrates. To achieve a one-pot (+)-alliin production, we constructed Escherichia coli coexpressing the genes encoding tryptophan synthase from Aeromonas hydrophila ssp...
February 28, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38409399/assessing-safety-efficacy-and-residue-depletion-in-golden-mahseer-tor-putitora-hamilton-1822-biochemical-and-physiological-responses-to-graded-concentrations-of-oxytetracycline-dietary-supplementation
#9
JOURNAL ARTICLE
Sumanta Kumar Mallik, Prasanna Kumar Patil, Neetu Shahi, Krishna Kala, Shivam Singh, Richa Pathak, Ritesh Shantilal Tandel, Amit Pande, Pramod Kumar Pandey
The safety and effectiveness of oxytetracycline can potentially manage bacterial infections in fish. This, in turn, might reduce the concerns related to its use in aquaculture and human consumption, such as toxicity, antimicrobial resistance, and other associated risks. The primary objective of this study was to assess how adding oxytetracycline dihydrate to the diet affects its effectiveness, safety, and the presence of residues in T. putitora. T. putitora fingerlings, subjected to experimental infection with Aeromonas hydrophila at a concentration of 108 CFU mL- 1 , received an oral administration of oxytetracycline dihydrate...
February 27, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38408546/antimicrobial-activity-of-probiotic-bacteria-mediated-cadmium-oxide-nanoparticles-against-fish-pathogens
#10
JOURNAL ARTICLE
Shanmugam Rajeshkumar, Santhoshkumar Jayakodi, M Tharani, Naiyf S Alharbi, Muthu Thiruvengadam
The current research was designed to investigate the antibacterial activity of probiotic bacteria mediated cadmium oxide nanoparticles (CdO NPs) on common fish pathogenic bacteria like Serratia marcescens, Aeromonas hydrophila, Vibrio harveyi, and V. parahaemolyticus. CdO NPs were synthesized using probiotic bacteria as follows: Lactobacillus species with different precursor of cadmium sulfate concentrations (5, 10, and 20 mM). The average crystalline sizes of the CdO NPs were determined based on the XRD patterns using the Debye-Scherrer equation for different precursor concentrations...
February 24, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38399819/antibacterial-mechanisms-and-antivirulence-activities-of-oridonin-against-pathogenic-aeromonas-hydrophila-as-1-1801
#11
JOURNAL ARTICLE
Lunji Wang, Huijuan Li, Jinhao Chen, Yi Wang, Yuqing Gu, Min Jiu
Aeromonas hydrophila , a Gram-negative bacterium widely found in freshwater environments, acts as a common conditional pathogen affecting humans, livestock, and aquatic animals. In this study, the impact of oridonin, an ent -kaurane diterpenoid compound derived from Rabdosia rubescens , on the virulence factors of A. hydrophila AS 1.1801 and its antibacterial mechanism was elucidated. The minimum inhibitory concentration (MIC) of oridonin against A. hydrophila AS 1.1801 was 100 μg/mL. Oridonin at inhibitory concentrations could significantly increase the electrical conductivity in the supernatant and escalate nucleic acid leakage ( p < 0...
February 19, 2024: Microorganisms
https://read.qxmd.com/read/38399667/the-presence-of-four-pathogenic-oral-bacterial-species-in-six-wild-snake-species-from-southern-taiwan-associated-factors
#12
JOURNAL ARTICLE
Wen-Hao Lin, Tein-Shun Tsai, Po-Chun Chuang
The oral cavity of snakes serves as a habitat for various microorganisms, some of which may include potential zoonotic pathogens posing risks to hosts and causing wound infections in snakebite victims. Clinical studies on snakebite cases in Taiwan have identified specific pathogens, such as Enterococcus faecalis (Gram-positive), Morganella morganii , Aeromonas hydrophila , and Pseudomonas aeruginosa (Gram-negative). However, the prevalence of these bacteria in the oral cavity of wild snakes remains largely unknown...
January 26, 2024: Microorganisms
https://read.qxmd.com/read/38397529/microbiological-and-toxicological-investigations-on-bivalve-molluscs-farmed-in-sicily
#13
JOURNAL ARTICLE
Annamaria Castello, Vincenzina Alio, Gaetano Cammilleri, Sonia Sciortino, Andrea Macaluso, Vincenzo Ferrantelli, Sonia Dall'Ara, Fiorella Pino, Irene Servadei, Giuseppa Oliveri, Antonella Costa
Bivalves can concentrate biological and chemical pollutants, causing foodborne outbreaks whose occurrence is increasing, due to climatic and anthropic factors that are difficult to reverse, hence the need for improved surveillance. This study aimed to evaluate the hygienic qualities of bivalves sampled along the production and distribution chain in Sicily and collect useful data for consumer safety. Bacteriological and molecular analyses were performed on 254 samples of bivalves for the detection of enteropathogenic Vibrio , Arcobacter spp...
February 11, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38391552/-aeromonas-spp-in-freshwater-bodies-antimicrobial-resistance-and-biofilm-assembly
#14
JOURNAL ARTICLE
Maria Nascimento, Joao Rodrigues, Rui Matias, Luisa Jordao
Aeromonas spp. are environmental bacteria able to infect animals and humans. Here, we aim to evaluate the role of biofilms in Aeromonas persistence in freshwater. Aeromonas were isolated from water and biofilm samples and identified by Vitek-MS and 16S rRNA sequencing. Antibiotic susceptibility profiles were determined according to EUCAST, and a crystal violet assay was used to assess biofilm assembly. MTT and the enumeration of colony-forming units were used to evaluate biofilm and planktonic Aeromonas susceptibility to chlorination, respectively...
February 8, 2024: Antibiotics
https://read.qxmd.com/read/38379546/high-replacement-of-soybean-meal-by-different-types-of-rapeseed-meal-is-detrimental-to-rainbow-trout-oncorhynchus-mykiss-growth-antioxidant-capacity-non-specific-immunity-and-aeromonas-hydrophila-tolerance
#15
JOURNAL ARTICLE
Wen Jiang, Hengzhi Wang, Lu Zhang, Haifeng Mi, Junming Deng
A 12-week feeding trial was conducted to evaluate the effects of replacing soybean meal with different types of rapeseed meal (RSM; Chinese 95-type (oil press model) rapeseed meal [C95RM], Chinese 200-type rapeseed meal [C200RM], cold pressed rapeseed cake [CPRC], Indian rapeseed meal [IRM] and Canadian rapeseed meal [CRM]) on growth, antioxidant capacity, non-specific immunity and Aeromonas hydrophila infection tolerance in 990 fingering (average weight 12.77 ± 0.01 g) rainbow trout ( Oncorhynchus mykiss )...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38376818/lysozyme-peptides-as-a-novel-nutra-preservative-to-control-some-food-poisoning-and-food-spoilage-microorganisms
#16
JOURNAL ARTICLE
Adham M Abdou, Dina A B Awad
Foodborne illnesses and microbial food contamination are crucial concerns and still issues of great worldwide concern. Additionally, the serious health hazards associated with the use of chemical preservatives in food technology. Lysozyme (Lz) is an active protein against Gram-positive bacterial cell wall through its muramidase lytic activity; however, several authors could identify some antimicrobial peptides derived from Lz that have an exaggerated and broad-spectrum antibacterial activity. Therefore, a lysozyme peptides preparation (LzP) is developed to broaden the Lz spectrum...
February 20, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38373897/methyl-gallate-from-camellia-nitidissima-chi-flowers-reduces-quorum-sensing-related-virulence-and-biofilm-formation-against-aeromonas-hydrophila
#17
JOURNAL ARTICLE
Huan Jiang, Zhennan Wang, Ai-Qun Jia
Aeromonas hydrophila , a Gram-negative zoonotic bacterium, causes high mortality in fish farming and immunocompromised patients. This study aimed to extract methyl gallate (MG) from the flowers of Camellia nitidissima Chi and evaluate its potential as a quorum sensing inhibitor (QSI) against Aeromonas hydrophila SHAe 115. MG reduced QS-associated virulence factors, including hemolysis, protease, and lipase, while impairing swimming motility and biofilm formation. Additionally, MG down-regulated positive regulatory genes ( ahyR , fleQ ) and up-regulated negative regulators ( litR , fleN )...
February 19, 2024: Biofouling
https://read.qxmd.com/read/38372806/streptomyces-enissocaesilis-l-82-has-broad-spectrum-antibacterial-activity-and-promotes-growth-for-carassius-auratus
#18
JOURNAL ARTICLE
Wensu Long, Wenjuan Zhao, Liangliang He, Tahir Ali Khan, Ximiao Lai, Yunjun Sun, Weitao Huang, Ganfeng Yi, Liqiu Xia
Aeromonas is the main pathogen causing bacterial diseases in fish. The disadvantages of chemical drugs to control fish diseases have been highlighted, and it is urgent to find an eco-friendly control method. In this study, an actinomycete strain with antibacterial activity against fish pathogenic bacteria was screened from soil samples. Combined with morphological characteristics, physiological and biochemical characteristics, and gyrB gene and whole genome comparison analysis, it was identified as a new strain of Streptomyces enissocaesilis, named Streptomyces enissocaesilis L-82...
February 19, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38371296/cross-sectional-analysis-of-risk-factors-associated-with-mugil-cephalus-in-retail-fish-markets-concerning-methicillin-resistant-staphylococcus-aureus-and-aeromonas-hydrophila
#19
JOURNAL ARTICLE
Amira S A Attia, Rasha M M Abou Elez, Nashwa El-Gazzar, Shimaa S Elnahriry, Ahmed Alfifi, Helal F Al-Harthi, Dalal Hussien M Alkhalifah, Wael N Hozzein, Hassan Mohmoud Diab, Doaa Ibrahim
INTRODUCTION: Aeromonas hydrophila and methicillin-resistant Staphylococcus aureus (MRSA) are potent bacterial pathogens posing major hazards to human health via consuming fish harboring these pathogens or by cross-contamination beyond the contaminated environment. The aim of this study was to determine risk variables associated with the presence of certain pathogenic bacteria from Mugil cephalus fish in retail markets in Egypt. The virulence genes of A. hydrophila and S. aureus were also studied...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38370905/detection-of-aeromonas-hydrophila-possessing-aerolysin-gene-using-gold-nanoparticle-probe
#20
JOURNAL ARTICLE
Arren Christian M de Guia, Mary Rose D Uy-de Guia, Juvy J Monserate, Joel R Salazar, Ravelina R Velasco, Claro N Mingala, Karl Marx A Quiazon
OBJECTIVE: The aerolysin (aerA) is a virulence indicator used to identify the pathogenicity of the Aeromonas strain. Targeting a pathogen's crucial virulence gene for detection is essential, as it determines the potential threat to the host. This study aimed to develop a gold nanoparticle (AuNP) probe for detecting the gene aer A in Aeromonas hydrophila among field samples. MATERIALS AND METHODS: Kidney samples among both healthy and sick Nile tilapias in five provinces of Luzon Island were collected for bacterial analysis...
December 2023: Journal of Advanced Veterinary and Animal Research
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