Kylie I Krohmaly, Marcos Perez-Losada, Ignacio Ramos-Tapia, Zhaozhong Zhu, Kohei Hasegawa, Carlos A Camargo, Brennan Harmon, Janice A Espinola, Laura Reck Cechinel, Rachael Batabyal, Robert J Freishtat, Andrea Hahn
Bronchiolitis, a viral lower respiratory infection, is the leading cause of infant hospitalization, which is associated with an increased risk for developing asthma later in life. Bronchiolitis can be caused by several respiratory viruses, such as respiratory syncytial virus (RSV), rhinovirus (RV), and others. It can also be caused by a solo infection (e.g., RSV- or RV-only bronchiolitis) or co-infection with two or more viruses. Studies have shown viral etiology-related differences between RSV- and RV-only bronchiolitis in the immune response, human microRNA (miRNA) profiles, and dominance of certain airway microbiome constituents...
2024: Frontiers in Immunology