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Kingella kingae in childrens

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https://www.readbyqxmd.com/read/29707061/the-efficacy-of-16s-ribosomal-dna-sequencing-in-the-diagnosis-of-bacteria-from-blood-bone-and-synovial-fluid-samples-of-children-with-musculoskeletal-infections
#1
S Hashavya, I Gross, A Michael-Gayego, N Simanovsky, R Lamdan
Background: Musculoskeletal infections are among the most common bacterial infections in children leading to hospitalization, invasive procedures and prolonged antibiotic administration. Blood, synovial and sometimes tissue cultures are essential for the diagnosis and treatment of musculoskeletal infections; 16S ribosomal DNA (rDNA) sequencing is a novel diagnostic tool for the detection of bacteria.While the yield of 16S rDNA sequencing in synovial fluid was previously assessed, data regarding the efficacy of this method from blood samples or partially treated children with suspected musculoskeletal infections is lacking...
April 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29705992/outpatients-with-acute-osteoarticular-infections-had-favourable-outcomes-when-they-received-just-oral-antibiotics-without-intravenous-antibiotics
#2
Rosa Alcobendas, Agustín Remesal, Sara Murias, Esmeralda Nuñez, Cristina Calvo
AIM: The traditional approach for acute paediatric osteoarticular infections (OAI) has comprised initial intravenous antibiotics followed by prompt oral antibiotics. We assessed how providing just oral antibiotics compared to the traditional two-step approach. METHODS: This prospective study was performed at the Hospital La Paz, Madrid, Spain, from September 2015 to September 2016. We compared 25 outpatients, with good general health and a mean age of 25 months who received just oral antibiotics, with 228 hospitalised children of a similar age who received intravenous and oral antibiotics from other hospitals in the Spanish Network of Osteoarticular Infections...
April 29, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29629576/spinal-infections-in-children
#3
MULTICENTER STUDY
R Dayer, M M Alzahrani, N Saran, J A Ouellet, P Journeau, A Tabard-Fougère, S Martinez-Álvarez, D Ceroni
Aims This multicentre, retrospective study aimed to improve our knowledge of primary pyogenic spinal infections in children by analyzing a large consecutive case series. Patients and Methods The medical records of children with such an infection, treated at four tertiary institutions between 2004 and 2014, were analyzed retrospectively. Epidemiological, clinical, paraclinical, radiological, and microbiological data were evaluated. There were 103 children, of whom 79 (76.7%) were aged between six months and four years...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29620718/kingella-kingae-as-the-main-cause-of-septic-arthritis-importance-of-molecular-diagnosis
#4
María Belén Hernández-Rupérez, María Del Carmen Suárez-Arrabal, Ángel Villa-García, Sara Zarzoso-Fernández, Marisa Navarro-Gómez, Mar Santos-Sebastián, Azucena García-Martín, Mercedes Marín, Felipe González-Martínez, Javier Narbona-Cárceles, Paloma Cervera-Bravo, José Luis González-López, Teresa Hernández-Sampelayo, Jesús Saavedra-Lozano
BACKGROUND: Kingella kingae is an emergent pathogen causing septic arthritis (SA) in children. OBJECTIVES: To analyze the etiology of SA in children before and after the implementation of universal 16S rRNA gene polymerase chain reaction and sequencing (16SPCR) in synovial fluid. METHODS: Children ≤ 14 years with acute SA from a Madrid cohort (2002-2013), were reviewed. Differences in etiology were analyzed before (Period 1) and after (Period 2) the implementation of bacterial 16SPCR in 2009...
March 31, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29587602/kingella-kingae-hand-and-wrist-tenosynovitis-in-young-children
#5
Nawal El Houmami, Pablo Yagupsky, Dimitri Ceroni
No abstract text is available yet for this article.
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29581191/-kingella-kingae-surface-polysaccharides-promote-resistance-to-human-serum-and-virulence-in-a-juvenile-rat-model
#6
Vanessa L Muñoz, Eric A Porsch, Joseph W St Geme
Kingella kingae is a gram-negative coccobacillus that is being recognized increasingly as an important cause of invasive disease in young children. The pathogenesis of K. kingae disease begins with colonization of the oropharynx, followed by invasion of the bloodstream, survival in the intravascular space, and dissemination to distant sites. Recent studies have revealed that K. kingae produces a number of surface factors that may contribute to the pathogenic process, including a polysaccharide capsule and an exopolysaccharide...
March 26, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29569505/risk-factors-associated-with-complications-sequelae-of-acute-and-subacute-haematogenous-osteomyelitis-an-italian-multicenter-study
#7
Elena Chiappini, Andrzej Krzysztofiak, Elena Bozzola, Clara Gabiano, Susanna Esposito, Andrea Lo Vecchio, Maria Rita Govoni, Cristina Vallongo, Icilio Dodi, Elio Castagnola, Nadia Rossi, Piero Valentini, Fabio Cardinale, Filippo Salvini, Gianni Bona, Grazia Bossi, Alma Nunzia Olivieri, Fiorella Russo, Emilio Fossali, Gabriella Bottone, Marta Dellepiane, Maurizio de Martino, Alberto Villani, Luisa Galli
BACKGROUND: Acute/subacute haematogenous osteomyelitis (AHOM/SAHOM) are potentially devastating diseases. Updated information about the epidemiology, management and outcome of AHOM/SAHOM is needed to minimize the risk of complications and sequelae. METHODS: A multicenter study was performed to evaluate retrospectively the management and outcome of AHOM/SAHOM in Italy. Data from children aged>1 month, and hospitalized between 2010 and 2016, in 19 pediatric centers, were analyzed...
March 23, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29478504/recognition-of-kingella-kingae-as-a-major-cause-of-osteoarticular-infections-in-young-children
#8
Sarah S Long
No abstract text is available yet for this article.
March 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29290233/antibiotic-therapy-of-bone-and-joint-infections-in-children-proposals-of-the-french-pediatric-infectious-disease-group
#9
M Lorrot, Y Gillet, C Gras Le Guen, E Launay, R Cohen, E Grimprel
Acute hematogenous bone and joint infections (osteomyelitis, septic arthritis, osteoarthritis, and spondylodiscitis) affect more frequently children younger than 5 years of age. Early diagnosis and prompt treatment are needed to limit the risk of complications. Children with suspected bone and joint infections (BJI) should be hospitalized at the beginning of treatment. Surgical drainage is indicated in patients with septic arthritis and in those with periosteal abscess. Staphylococcus aureus is involved in BJIs in children at all ages; Kingella kingae is a very common causative pathogen in children under 4 years of age...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29246347/temporal-association-between-rhinovirus-activity-and-kingella-kingae-osteoarticular-infections
#10
Nina Droz, Vincent Enouf, Philippe Bidet, Damir Mohamed, Sylvie Behillil, Anne-Laure Simon, Manon Bachy, Marion Caseris, Stéphane Bonacorsi, Romain Basmaci
OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29181961/atypical-causes-of-bacterial-osteoarticular-infections-in-immunocompetent-children
#11
Walter Dehority
Caring for a child with an osteoarticular infection or considering the possibility of an osteoarticular infection in a child is one of the most common clinical dilemmas encountered by clinicians caring for children. In such a scenario, one most often considers infection with frequently encountered pathogens such as Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae or Kingella kingae. A large variety of opportunistic osteoarticular pathogens may be found in the immunosuppressed patient or the postoperative or post-trauma patient, due to breaches in the immune system and nosocomial or post-traumatic exposure to multiple organisms...
December 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29164082/acute-septic-arthritis-of-the-knee-caused-by-kingella-kingae-in-a-5-year-old-cameroonian-boy
#12
Nawal El Houmami, Dimitri Ceroni, Karine Codjo Seignon, Jean-Christophe Pons, Cédric Lambert, Guillaume André Durand, Philippe Minodier, Léopold Lamah, Philippe Bidet, Jacques Schrenzel, Didier Raoult, Pierre-Edouard Fournier
Kingella kingae is an important cause of invasive infections in young children from Western countries. Although increasing reports indicate that this organism is the leading agent of bone and joint infections in early childhood, data on K. kingae infections from resource-limited settings are scarce, and none has yet been reported in Africa. We herein report the diagnostic and epidemiological investigations of the first case of K. kingae arthritis identified in a child from sub-Saharan Africa. A 5-year-old Cameroonian boy presented with a sudden painful limp which appeared in the course of a mild rhinopharyngitis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29058252/a-transversal-pilot-study-of-oropharyngeal-carriage-of-kingella-kingae-in-healthy-children-younger-than-6-months
#13
Vasiliki Spyropoulou, Gabriel Brändle, Albane Bertha Rosa Maggio, Rebecca Anderson Della Llana, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano, Dimitri Ceroni
BACKGROUND: The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life. METHODS: We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate. Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections. RESULTS: We demonstrated an oropharyngeal carriage rate of 0...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28991319/-etiology-and-evolution-of-the-osteoarticular-infections-2009-2015-pediatric-hospital-pereira-rossell-uruguay
#14
Carlos Zuníno, Alejandra Vomero, Soledad Pandolfo, Claudia Gutiérrez, Gabriela Algorta, M Catalina Pírez, Gustavo Giachetto
BACKGROUND: The most frequent osteoarticular infections (OAI) etiological agent is Staphylococcus aureus. The prevalence of other microorganisms has changed after the introduction of new vaccines. AIM: To describe the etiology and evolution of the OAIs in children hospitalized in Pediatric Hospital Pereira Rossell between 2009 and 2015. PATIENTS AND METHODS: Joint fluid and bone puncture studies of hospitalized children suspected of OAI. Epidemiological characteristics, isolated microorganisms, complementary tests, initial treatment, complications, and days of hospitalization were analyzed...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28946848/a-modified-multilocus-sequence-typing-protocol-to-genotype-kingella-kingae-from-oropharyngeal-swabs-without-bacterial-isolation
#15
Nawal El Houmami, Janek Bzdrenga, Jean-Christophe Pons, Philippe Minodier, Guillaume André Durand, Anis Oubraham, Dimitri Ceroni, Pablo Yagupsky, Didier Raoult, Philippe Bidet, Pierre-Edouard Fournier
BACKGROUND: Outbreaks of Kingella kingae infection are an emerging public health concern among daycare attendees carrying epidemic clones in the oropharynx. However, genotyping of such epidemic clones from affected cases is limited by the low performance of current methods to detect K. kingae from blood samples and lack of specimens available from infected sites. We aimed at developing a modified multilocus sequence typing (MLST) method to genotype K. kingae strains from oropharyngeal samples without prior culture...
September 21, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28918656/diagnosing-kingella-kingae-infections-in-infants-and-young-children
#16
Pablo Yagupsky
Kingella kingae is currently recognized as the prime etiology of skeletal system infections in children aged 6-48 months. The organism is notoriously fastidious, its growth is inhibited by synovial fluid and bone exudates, and its presence in clinical specimens is commonly missed by traditional culture methods. Areas covered: The present review discusses the use of improved laboratory methods to detect the organism in normally sterile body fluids, exudates, and upper respiratory tract specimens. Expert commentary: While inoculation of joint and bone exudates into blood culture vials dilutes the concentration of detrimental factors and significantly improves the isolation of the organism, novel PCR-based assays have enhanced sensitivity, shortened the time-to-detection of K...
October 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28914110/evaluation-of-dual-target-specific-real-time-pcr-for-the-detection-of-kingella-kingae-in-a-danish-paediatric-population
#17
Victoria Elizabeth de Knegt, Gitte Qvist Kristiansen, Kristian Schønning
BACKGROUND: We aimed to evaluate the relevance of dual target real-time polymerase chain (PCR) assays targeting the rtxA and cpn60 genes of the paediatric pathogen Kingella kingae. We also studied for the first time the clinical and epidemiological features of K. kingae infections in a Danish population. METHOD: Children with K. kingae-positive cultures were identified from 11,477 children and 86 children younger than 16 years old from whom blood cultures and joint fluid cultures were obtained between January 2010 and November 2016...
March 2018: Infectious Diseases
https://www.readbyqxmd.com/read/28874431/association-between-oropharyngeal-carriage-of-kingella-kingae-and-osteoarticular-infection-in-young-children-a-case-control-study
#18
MULTICENTER STUDY
Jocelyn Gravel, Dimitri Ceroni, Laurence Lacroix, Christian Renaud, Guy Grimard, Eleftheria Samara, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano
BACKGROUND: Kingella kingae has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of K. kingae in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician...
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28874408/defining-the-mechanical-determinants-of-kingella-kingae-adherence-to-host-cells
#19
Brad K Kern, Eric A Porsch, Joseph W St Geme
Kingella kingae is an important pathogen in young children and initiates infection by colonizing the posterior pharynx. Adherence to pharyngeal epithelial cells is an important first step in the process of colonization. In the present study, we sought to elucidate the interplay of type IV pili (T4P), a trimeric autotransporter adhesin called Knh, and the polysaccharide capsule in K. kingae adherence to host cells. Using adherence assays performed under shear stress, we observed that a strain expressing only Knh was capable of higher levels of adherence than a strain expressing only T4P...
December 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28802585/genomics-of-the-new-species-kingella-negevensis-diagnostic-issues-and-identification-of-a-locus-encoding-a-rtx-toxin
#20
Onya Opota, Sacha Laurent, Trestan Pillonel, Marie Léger, Sabrina Trachsel, Guy Prod'hom, Katia Jaton, Gilbert Greub
Kingella kingae, producing the cytotoxic RTX protein, is a causative agent of serious infections in humans such as bacteremia, endocarditis and osteoarticular infection, especially in young children. Recently, Kingella negevensis, a related species, has been isolated from the oral cavity of healthy children. In this study, we report the isolation of K. negevensis strain eburonensis, initially misidentified as K. kingae with MALDI-TOF MS, from a vaginal specimen of a patient suffering of vaginosis. The genome sequencing and analysis of this strain together with comparative genomics of the Kingella genus revealed that K...
August 10, 2017: Microbes and Infection
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