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Kingella kingae in childrens

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https://www.readbyqxmd.com/read/29058252/a-transversal-pilot-study-of-oropharyngeal-carriage-of-kingella-kingae-in-healthy-children-younger-than-6-months
#1
Vasiliki Spyropoulou, Gabriel Brändle, Albane Bertha Rosa Maggio, Rebecca Anderson Della Llana, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano, Dimitri Ceroni
BACKGROUND: The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life. METHODS: We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate. Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections. RESULTS: We demonstrated an oropharyngeal carriage rate of 0...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28991319/-etiology-and-evolution-of-the-osteoarticular-infections-2009-2015-pediatric-hospital-pereira-rossell-uruguay
#2
Carlos Zuníno, Alejandra Vomero, Soledad Pandolfo, Claudia Gutiérrez, Gabriela Algorta, M Catalina Pírez, Gustavo Giachetto
BACKGROUND: The most frequent osteoarticular infections (OAI) etiological agent is Staphylococcus aureus. The prevalence of other microorganisms has changed after the introduction of new vaccines. AIM: To describe the etiology and evolution of the OAIs in children hospitalized in Pediatric Hospital Pereira Rossell between 2009 and 2015. PATIENTS AND METHODS: Joint fluid and bone puncture studies of hospitalized children suspected of OAI. Epidemiological characteristics, isolated microorganisms, complementary tests, initial treatment, complications, and days of hospitalization were analyzed...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28946848/a-modified-multilocus-sequence-typing-protocol-to-genotype-kingella-kingae-from-oropharyngeal-swabs-without-bacterial-isolation
#3
Nawal El Houmami, Janek Bzdrenga, Jean-Christophe Pons, Philippe Minodier, Guillaume André Durand, Anis Oubraham, Dimitri Ceroni, Pablo Yagupsky, Didier Raoult, Philippe Bidet, Pierre-Edouard Fournier
BACKGROUND: Outbreaks of Kingella kingae infection are an emerging public health concern among daycare attendees carrying epidemic clones in the oropharynx. However, genotyping of such epidemic clones from affected cases is limited by the low performance of current methods to detect K. kingae from blood samples and lack of specimens available from infected sites. We aimed at developing a modified multilocus sequence typing (MLST) method to genotype K. kingae strains from oropharyngeal samples without prior culture...
September 21, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28918656/diagnosing-kingella-kingae-infections-in-infants-and-young-children
#4
Pablo Yagupsky
Kingella kingae is currently recognized as the prime etiology of skeletal system infections in children aged 6-48 months. The organism is notoriously fastidious, its growth is inhibited by synovial fluid and bone exudates, and its presence in clinical specimens is commonly missed by traditional culture methods. Areas covered: The present review discusses the use of improved laboratory methods to detect the organism in normally sterile body fluids, exudates, and upper respiratory tract specimens. Expert commentary: While inoculation of joint and bone exudates into blood culture vials dilutes the concentration of detrimental factors and significantly improves the isolation of the organism, novel PCR-based assays have enhanced sensitivity, shortened the time-to-detection of K...
October 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28914110/evaluation-of-dual-target-specific-real-time-pcr-for-the-detection-of-kingella-kingae-in-a-danish-paediatric-population
#5
Victoria Elizabeth de Knegt, Gitte Qvist Kristiansen, Kristian Schønning
BACKGROUND: We aimed to evaluate the relevance of dual target real-time polymerase chain (PCR) assays targeting the rtxA and cpn60 genes of the paediatric pathogen Kingella kingae. We also studied for the first time the clinical and epidemiological features of K. kingae infections in a Danish population. METHOD: Children with K. kingae-positive cultures were identified from 11,477 children and 86 children younger than 16 years old from whom blood cultures and joint fluid cultures were obtained between January 2010 and November 2016...
September 15, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28874431/association-between-oropharyngeal-carriage-of-kingella-kingae-and-osteoarticular-infection-in-young-children-a-case-control-study
#6
MULTICENTER STUDY
Jocelyn Gravel, Dimitri Ceroni, Laurence Lacroix, Christian Renaud, Guy Grimard, Eleftheria Samara, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano
BACKGROUND: Kingella kingae has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of K. kingae in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician...
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28874408/defining-the-mechanical-determinants-of-kingella-kingae-adherence-to-host-cells
#7
Brad K Kern, Eric A Porsch, Joseph W St Geme
Kingella kingae is an important pathogen in young children and initiates infection by colonizing the posterior pharynx. Adherence to pharyngeal epithelial cells is an important first step in the process of colonization. In the present study, we sought to elucidate the interplay of type IV pili (T4P), a trimeric autotransporter adhesin called Knh, and the polysaccharide capsule in K. kingae adherence to host cells. Using adherence assays performed under shear stress, we observed that a strain expressing only Knh was capable of higher levels of adherence than a strain expressing only T4P...
December 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28802585/genomics-of-the-new-species-kingella-negevensis-diagnostic-issues-and-identification-of-a-locus-encoding-a-rtx-toxin
#8
Onya Opota, Sacha Laurent, Trestan Pillonel, Marie Léger, Sabrina Trachsel, Guy Prod'hom, Katia Jaton, Gilbert Greub
Kingella kingae, producing the cytotoxic RTX protein, is a causative agent of serious infections in humans such as bacteremia, endocarditis and osteoarticular infection, especially in young children. Recently, Kingella negevensis, a related species, has been isolated from the oral cavity of healthy children. In this study, we report the isolation of K. negevensis strain eburonensis, initially misidentified as K. kingae with MALDI-TOF MS, from a vaginal specimen of a patient suffering of vaginosis. The genome sequencing and analysis of this strain together with comparative genomics of the Kingella genus revealed that K...
August 10, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28794176/molecular-tests-that-target-the-rtx-locus-do-not-distinguish-between-kingella-kingae-and-the-recently-described-kingella-negevensis-species
#9
Nawal El Houmami, Janek Bzdrenga, Guillaume André Durand, Philippe Minodier, Hervé Seligmann, Elsa Prudent, Sofiane Bakour, Stéphane Bonacorsi, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
Kingella kingae is an important invasive pathogen in early childhood. The organism elaborates an RTX toxin presumably restricted to this species. Consequently, real-time quantitative PCR (qPCR) assays targeting the RTX locus have been developed in recent years and are gaining increasing use for the molecular diagnosis of K. kingae infections. However, the present study shows that Kingella negevensis, a Kingella species newly identified in young children, harbors an identical Kingella RTX locus, raising the question of whether K...
October 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28760709/antimicrobial-susceptibility-testing-of-kingella-kingae-with-broth-microdilution-and-disk-diffusion-using-eucast-recommended-media
#10
E Matuschek, J Åhman, G Kahlmeter, P Yagupsky
OBJECTIVES: Increasing use of improved culture techniques and sensitive nucleic acid amplification assays have resulted in recognition of Kingella kingae as an important cause of invasive infections in young children, especially in septic arthritis, osteomyelitis, bacteraemia, and endocarditis. In 2016, EUCAST established clinical MIC breakpoints for K. kingae (published in EUCAST Clinical Breakpoint Tables v 7.0, 2017). The present study was carried out to produce MIC-zone diameter correlations for K...
July 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28699877/isolation-and-characterization-of-kingella-negevensis-sp-nov-a-novel-kingella-species-detected-in-a-healthy-paediatric-population
#11
Nawal El Houmami, Sofiane Bakour, Janek Bzdrenga, Jaishiram Rathored, Hervé Seligmann, Catherine Robert, Nicholas Armstrong, Jacques Schrenzel, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
We herein report the isolation and characterization of 21 Gram-stain-negative strains cultivated from the oropharynx of healthy children in Israel and Switzerland. Initially described as small colony variants of Kingella kingae, phenotypic analysis, biochemical analysis, phylogenetic analysis based on sequencing of the partial 16S rRNA gene and five housekeeping genes (abcZ, adk, G6PD, groEL and recA), and whole genome sequencing and comparison between members of the genera Kingella and Neisseria provided evidence for assigning them to the genus Kingella...
July 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28661965/pyogenic-tenosynovitis-in-infants-a-case-series
#12
Céline Lironi, Christina Steiger, Céline Juchler, Vasiliki Spyropoulou, Eleftheria Samara, Dimitri Ceroni
Pyogenic tenosynovitis is an uncommon condition in children, and there are few published case reports. We present a series of 11 cases who were treated in the Geneva Children Hospital in the last 10 years. Kingella kingae was the main pathogen, and the characteristics of infection (inflammatory indices, clinical findings and severity) are similar to other osteoarticular K. kingae infections in infants.
November 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28650419/spondylodiscitis-by-kingella-kingae-an-emerging-pathogen-in-an-older-pediatric-population
#13
Sara Alexandra Fernandes Machado, Joana Manuel Ferreira Freitas, Nuno Paulo Alegrete da Silva, Jorge Manuel Coutinho Costa Moreira, Rui Alexandre Peixoto Pinto, Fernando Gilberto de Melo Costa
In children, greater than 95% of Kingella kingae infections are diagnosed between 6 and 48 months of age. K. kingae has not been systematically investigated, especially in older children. We describe a case of spondylodiscitis by K. kingae in an 8-year-old child.
November 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28607765/paediatric-bone-and-joint-infection
#14
REVIEW
Alexios D Iliadis, Manoj Ramachandran
Despite advances in understanding and management, paediatric osteoarticular infections continue to pose diagnostic difficulties for clinicians. Delays in diagnosis can lead to potentially devastating morbidity.No single investigation, including joint aspiration, is sufficiently reliable to diagnose conclusively paediatric bone and joint infection. Diagnosis should be based on a combination of clinical signs, imaging and laboratory investigations. Algorithms should supplement, and not replace, clinical decision making in all cases...
January 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28546880/kingella-kingae-keratitis-in-a-child-with-underlying-vernal-keratoconjunctivitis
#15
Salim Nurul-Laila, Khai-Siang Chai, Ahmad Tajudin Liza-Sharmini, Ismail Shatriah
Kingella kingae had rarely been reported as a causative organism for corneal ulcer and had not been described before in vernal keratoconjunctivitis (VKC). Generally regarded as commensals of respiratory tract particularly in young children, it had however been isolated from the corneal ulcer scraping of both adult and children. We report a case of bacterial ulcer with isolation of Kingella kingae from the corneal scraping in a young child with underlying VKC.
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28539344/investigation-of-kingella-kingae-invasive-infection-outbreaks-in-day-care-facilities-assessment-of-a-rapid-genotyping-tool-targeting-the-dna-uptake-sequence
#16
Philippe Bidet, Violaine Tran Quang, Pablo Yagusky, André Birgy, Stéphane Bonacorsi, Romain Basmaci
Outbreaks of Kingella kingae invasive infections have recently been reported in day care centers. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) revealed that although the invasive strains had widespread dissemination in the day care population, less virulent strains were also circulating in the facilities. However, these typing tools are costly, time-consuming, and labor-intensive and provide delayed results. A study was conducted to assess the performance of a rapid and cost-effective genotyping tool targeting the DNA uptake sequence (DUS) in the investigation of outbreaks of K...
August 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28373088/clinical-presentation-and-treatment-of-septic-arthritis-in-children
#17
I Moro-Lago, G Talavera, L Moraleda, G González-Morán
INTRODUCTION: The aim of this study is to determine the epidemiological features, clinical presentation, and treatment of children with septic arthritis. MATERIAL AND METHOD: A retrospective review was conducted on a total of 141 children with septic arthritis treated in Hospital Universitario La Paz (Madrid) between the years 2000 to 2013. The patient data collected included, the joint affected, the clinical presentation, the laboratory results, the appearance, Gram stain result, and the joint fluid culture, as well as the imaging tests and the treatment...
May 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28317027/the-type-a-and-type-b-polysaccharide-capsules-predominate-in-an-international-collection-of-invasive-kingella-kingae-isolates
#18
Eric A Porsch, Kimberly F Starr, Pablo Yagupsky, Joseph W St Geme
Kingella kingae is an encapsulated Gram-negative bacterium and an important etiology of osteoarticular infections in young children. A recent study examining a diverse collection of carrier and invasive K. kingae isolates from Israel revealed four distinct polysaccharide capsule types. In this study, to obtain a global view of K. kingae capsule type diversity, we examined an international collection of isolates using a multiplex PCR approach. The collection contained all four previously identified capsule types and no new capsule types...
March 2017: MSphere
https://www.readbyqxmd.com/read/27956728/kingella-kingae-chest-mass-mimicking-a-tumor-in-an-11-month-old-baby
#19
Halima Dabaja-Younis, Imad Kassis, Anat Ilivitzki, Ran Steinberg, Yael Shachor-Meyouhas
Kingella kingae has been recognized as a common etiology of pediatric osteoarticular infections, especially among children younger than 5 years of age. In recent years, there have been reported cases of unusual manifestations. We report a rare case of a chest mass mimicking a tumor in an 11-month-old baby.
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27760194/kingella-kingae-expresses-four-structurally-distinct-polysaccharide-capsules-that-differ-in-their-correlation-with-invasive-disease
#20
Kimberly F Starr, Eric A Porsch, Patrick C Seed, Christian Heiss, Radnaa Naran, L Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W St Geme
Kingella kingae is an encapsulated gram-negative organism that is a common cause of osteoarticular infections in young children. In earlier work, we identified a glycosyltransferase gene called csaA that is necessary for synthesis of the [3)-β-GalpNAc-(1→5)-β-Kdop-(2→] polysaccharide capsule (type a) in K. kingae strain 269-492. In the current study, we analyzed a large collection of invasive and carrier isolates from Israel and found that csaA was present in only 47% of the isolates. Further examination of this collection using primers based on the sequence that flanks csaA revealed three additional gene clusters (designated the csb, csc, and csd loci), all encoding predicted glycosyltransferases...
October 2016: PLoS Pathogens
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