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Kingella kingae in childrens

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https://www.readbyqxmd.com/read/27760194/kingella-kingae-expresses-four-structurally-distinct-polysaccharide-capsules-that-differ-in-their-correlation-with-invasive-disease
#1
Kimberly F Starr, Eric A Porsch, Patrick C Seed, Christian Heiss, Radnaa Naran, L Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W St Geme
Kingella kingae is an encapsulated gram-negative organism that is a common cause of osteoarticular infections in young children. In earlier work, we identified a glycosyltransferase gene called csaA that is necessary for synthesis of the [3)-β-GalpNAc-(1→5)-β-Kdop-(2→] polysaccharide capsule (type a) in K. kingae strain 269-492. In the current study, we analyzed a large collection of invasive and carrier isolates from Israel and found that csaA was present in only 47% of the isolates. Further examination of this collection using primers based on the sequence that flanks csaA revealed three additional gene clusters (designated the csb, csc, and csd loci), all encoding predicted glycosyltransferases...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27745829/-treatment-and-progression-of-acute-communautary-osteoarticular-infections-in-healthy-children-a-retrospective-monocentric-study-of-64%C3%A2-patients
#2
A Lemoine, F Baudin, R Vialle, E Grimprel
INTRODUCTION: The prognosis of osteoarticular infections has improved over the past 20 years but it still remains potentially severe. The treatment of these infections has been simplified and shortened. In 2008, the Pediatric Infectious Disease Group (GPIP) established new therapeutic guidelines in order to standardize treatment in France. The aim of this study is to analyze practices in a Parisian hospital and assess the efficacy of this treatment in short and medium terms. MATERIALS AND METHODS: This retrospective study focused on patients older than 3 months, without comorbidities, who were hospitalized for an acute osteoarticular infection in 2012 at Trousseau Hospital (Paris), with a follow-up of at least 4 weeks...
November 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27714987/in-vitro-characterization-of-biofilms-formed-by-kingella-kingae
#3
Jeffrey B Kaplan, Vandana Sampathkumar, Meriem Bendaoud, Alexander K Giannakakis, Edward T Lally, Nataliya V Balashova
The Gram-negative bacterium Kingella kingae is part of the normal oropharyngeal mucosal flora of children under four years old. K. kingae can enter the submucosa and cause infections of the skeletal system in children including septic arthritis and osteomyelitis. The organism is also associated with infective endocarditis in children and adults. Although biofilm formation has been coupled with pharyngeal colonization, osteoarticular infections, and infective endocarditis, no studies have investigated biofilm formation in K...
October 7, 2016: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/27669685/low-prevalence-of-kingella-kingae-carriage-in-children-aged-6-48-months-in-sydney-australia
#4
Ameneh Khatami, Braden Rl Rivers, Alexander C Outhred, Alison M Kesson
AIM: A prospective observational study was conducted to estimate the prevalence of oropharyngeal carriage of Kingella kingae in healthy Australian pre-school children. METHODS: Screening for carriage of K. kingae as well as Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Haemophilus influenzae, and K. kingae was undertaken using a single bacterial throat swab taken from well children aged 6 months to 4 years. Standard laboratory procedures were used for culture and identification of organisms...
September 27, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27639784/unusual-case-of-paediatric-septic-arthritis-of-the-lumbar-facet-joints-due-to-kingella-kingae
#5
M Le Hanneur, C Vidal, C Mallet, K Mazda, B Ilharreborde
A 32-month-old boy presented with febrile limping that had developed over 6days, associated with right lumbosacral inflammatory swelling. Magnetic resonance imaging (MRI) showed joint effusion of the right L5-S1 zygapophyseal joint, complicated by destructive osteomyelitis of the L5 articular process and paraspinal abscess. Surgery was decided to evacuate the fluid accumulation and rule out differential diagnoses. The diagnosis of septic arthritis of the facet joint was confirmed intraoperatively; real-time quantitative PCR analysis identified Kingella kingae...
September 14, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27586302/high-rate-of-oropharyngeal-kingella-kingae-carriage-in-new-zealand-children
#6
Laudi Olijve, Roslyn Podmore, Trevor Anderson, Tony Walls
AIM: This study aimed to describe the burden of disease and estimated rates of oropharyngeal carriage of Kingella kingae among New Zealand children. We compared polymerase chain reaction (PCR) and culture for the detection of this microorganism with a view to further development and implementation of K. kingae PCR in Christchurch Hospital. METHODS: Oropharyngeal swabs from children between 6 and 48 months of age were analysed by culture to estimate carriage rates of K...
September 1, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27420804/identifying-reservoirs-of-infections-caused-by-kingella-kingae-a-case-control-study-of-oropharyngeal-carriage-of-k-kingae-among-healthy-adults
#7
Gabriel Brändle, Vasiliki Spyropoulou, Albane B R Maggio, Rebecca Anderson de la Llana, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano, Dimitri Ceroni
BACKGROUND: Kingella kingae is currently recognized as a significant pathogen of the pediatric population. Nevertheless, the possibility for adults to serve as a reservoir of healthy carriers has not been studied. METHOD: We conducted a monocentric transversal study on 228 healthy adults to define the carriage rate. Participants were recruited among the staff of a children's hospital, a population exposed to aerosolized droplets from children. A secondary analysis using a case-control method was conducted to assess risk factors for carriage...
August 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27408498/spinal-infections-in-children-a-review
#8
REVIEW
Rahul Tyagi
Spinal infections are uncommon but significant causes of morbidity and hospitalization in the paediatric population. These infections encompass a broad range of conditions, from discitis to osteomyelitis and spinal epidural and intramedullary abscesses. Paediatric spinal infections can be caused by a range of bacterial, viral, fungal and parasitic agents. Ultrastructural differences of the vertebrae and associated structures result in distinct mechanisms of pathogenesis of spinal infections in children compared to adults...
December 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27174185/primary-subacute-hematogenous-osteomyelitis-in-children-a-clearer-bacteriological-etiology
#9
Vasiliki Spyropoulou, Amira Dhouib Chargui, Laura Merlini, Eleftheria Samara, Raimonda Valaikaite, Georgios Kampouroglou, Dimitri Ceroni
BACKGROUND: This study aimed to describe the spectrum of pediatric primary subacute hematogenous osteomyelitis (PSAHO) and to investigate its bacterial etiology. METHODS: Sixty-five consecutive cases of PSAHO admitted to our institution over a 16-year period (2000-2015) were retrospectively reviewed to assess their laboratory and radiographic imaging features, as well as their bacteriological etiology. RESULTS: On evaluation, white blood cell count and C-reactive protein were normal in 53 (81...
June 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27095882/polymerase-chain-reaction-detection-of-kingella-kingae-in-children-with-culture-negative-septic-arthritis-in-eastern-ontario
#10
Robert Slinger, Ioana Moldovan, Jennifer Bowes, Francis Chan
BACKGROUND: The bacterium Kingella kingae may be an under-recognized cause of septic arthritis in Canadian children because it is difficult to grow in culture and best detected using molecular methods. OBJECTIVES: To determine whether K kingae is present in culture-negative joint fluid specimens from children in eastern Ontario using polymerase chain reaction (PCR) detection methods. METHODS: K kingae PCR testing was performed using residual bacterial culture-negative joint fluid collected from 2010 to 2013 at a children's hospital in Ottawa, Ontario...
March 2016: Paediatrics & Child Health
https://www.readbyqxmd.com/read/27070599/infectious-discitis-and-spondylodiscitis-in-children
#11
REVIEW
Nicola Principi, Susanna Esposito
In children, infectious discitis (D) and infectious spondylodiscitis (SD) are rare diseases that can cause significant clinical problems, including spinal deformities and segmental instabilities. Moreover, when the infection spreads into the spinal channel, D and SD can cause devastating neurologic complications. Early diagnosis and treatment may reduce these risks. The main aim of this paper is to discuss recent concepts regarding the epidemiology, microbiology, clinical presentation, diagnosis, and treatment of pediatric D and SD...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27045037/genetic-and-molecular-basis-of-kingella-kingae-encapsulation
#12
Kimberly F Starr, Eric A Porsch, Patrick C Seed, Joseph W St Geme
Kingella kingae is a common cause of invasive disease in young children and was recently found to produce a polysaccharide capsule containing N-acetylgalactosamine (GalNAc) and β-3-deoxy-d-manno-octulosonic acid (βKdo). Given the role of capsules as important virulence factors and effective vaccine antigens, we set out to determine the genetic determinants of K. kingae encapsulation. Using a transposon library and a screen for nonencapsulated mutants, we identified the previously identified ctrABCD (ABC transporter) operon, a lipA (kpsC)-like gene, a lipB (kpsS)-like gene, and a putative glycosyltransferase gene designated csaA (capsule synthesis type a gene A)...
June 2016: Infection and Immunity
https://www.readbyqxmd.com/read/26946080/uncommon-kingella-kingae-lytic-bone-lesions-in-children
#13
EDITORIAL
Margarida Alcafache, Susana Ramos, Pedro Alves, Delfin Tavares, Catarina Gouveia
No abstract text is available yet for this article.
March 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26810096/kingella-kingae-infections-can-cluster-among-young-children-in-close-contact
#14
Sarah S Long
No abstract text is available yet for this article.
February 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26738763/epidemiologic-and-microbiologic-characteristics-of-occult-bacteremia-among-febrile-children-in-southern-israel-before-and-after-initiation-of-the-routine-antipneumococcal-immunization-2005-2012
#15
Haya Ribitzky-Eisner, Yitamar Minuhin, David Greenberg, Ninel Greenberg, Gabriel Chodick, Mihai Craiu, Eugene Leibovitz
BACKGROUND: Little is known about the incidence and dynamics of occult bacteremia (OB) among infants/young children following the introduction of pneumococcal conjugate vaccines (PCVs) into the national immunization program in Israel in 2009-2010. The aim of this study was to characterize the epidemiologic and microbiologic picture of OB among febrile infants/children aged 3-36 months in southern Israel, before and after PCVs introduction. METHODS: Retrospective study enrolling all infants/young children attending the emergency room of a tertiary medical center in southern Israel with fever without source, discharged, and reported with a positive blood culture...
October 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/26715611/genotyping-and-resolution-of-a-case-of-osteomyelitis-in-a-16-month-old-boy-of-hispanic-african-american-ethnicity
#16
Eunice Wachira, Kayla Tran, Sara Taylor, Sally Hoger, James Dunn
Most cases of osteomyelitis in children are caused by Staphylococcus aureus, although Kingella kingae, various streptococci, and Salmonella species also underlie this condition. Organisms such as Mycobacterium, Histoplasma, and Cryptococcus are much less commonly identified as etiologic agents in osteomyelitis. This case report describes a 16-month-old boy of Hispanic/African American ethnicity who had extensive inflammation of and discharge from his right ankle. Imaging studies supported a diagnosis of osteomyelitis...
February 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/26658382/patterns-of-kingella-kingae-disease-outbreaks
#17
REVIEW
Nawal El Houmami, Philippe Minodier, Grégory Dubourg, Audrey Mirand, Jean-Luc Jouve, Romain Basmaci, Rémi Charrel, Stéphane Bonacorsi, Pablo Yagupsky, Didier Raoult, Pierre-Edouard Fournier
BACKGROUND: Kingella kingae outbreaks occur sporadically in childcare centers but remain poorly understood and difficult to identify. METHODS: To provide the basis of a better knowledge of K. kingae outbreaks patterns that may help to guide identification and management strategies, we collected epidemiological, clinical and laboratory data from all reported K. kingae outbreaks, and those from 2 new Israel outbreaks in 2014. RESULTS: Nine outbreaks were identified in the USA, Israel and France from 2003 to 2014...
March 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26625369/age-dependent-carriage-of-kingella-kingae-in-young-children-and-turnover-of-colonizing-strains
#18
Uri Amit, Sandra Flaishmakher, Ron Dagan, Nurith Porat, Pablo Yagupsky
In a longitudinal study, Kingella kingae carriage rate was nil below 6 months of age, 1.5% at 6 months, 9.6% at 12 months, remained stable between 10.4% and 12.0% during the second year of life, and decreased significantly to 5.3% at 30 months. Replacement of carried strains occurred over time.
June 2014: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/26545728/outbreaks-of-invasive-kingella-kingae-infections-in-closed-communities
#19
Pablo Yagupsky, Yael Ben-Ami, Ronit Trefler, Nurith Porat
OBJECTIVES: To describe the results of the epidemiologic investigation of outbreaks of invasive Kingella kingae infections among attendees at daycare facilities located in 4 closed communities in Israel. STUDY DESIGN: The preschool-aged population of communities with clusters of Kingella cases had oropharyngeal cultures performed. K kingae isolates from infected patients and healthy contacts were genotyped by pulsed field gel electrophoresis to determine the spread of outbreak strains...
February 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26506055/what-to-expect-from-molecular-tools-for-non-documented-pediatric-infectious-diseases
#20
Anne Filleron, Anne-Laure Michon, Estelle Jumas-Bilak, Eric Jeziorski, Isabelle Zorgniotti, Tu Anh Tran, Thomas Filleron, Michel Rodière, Hélène Marchandin
OBJECTIVE: Evaluation of the contribution of molecular tools to the overall diagnosis of infectious diseases in children. METHODS: Results of 16S rDNA analysis (179 children; 228 specimens), combined to specific amplification of Kingella kingae (126 children; 166 osteoarticular specimens), were retrospectively analyzed for samples with inconclusive cultures. RESULT: The overall positive yield in diagnosis was 12.8% of the patients for 16S rDNA PCR, 40...
2015: Expert Review of Molecular Diagnostics
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