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Kingella kingae in childrens

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https://www.readbyqxmd.com/read/28802585/genomics-of-the-new-species-kingella-negevensis-diagnostic-issues-identification-of-a-locus-encoding-a-rtx-toxin
#1
Onya Opota, Sacha Laurent, Trestan Pillonel, Marie Léger, Sabrina Trachsel, Guy Prod'hom, Katia Jaton, Gilbert Greub
Kingella kingae, producing the cytotoxic RTX protein, is a causative agent of serious infections in humans such as bacteremia, endocarditis and osteoarticular infection, especially in young children. Recently, Kingella negevensis, a related species, has been isolated from the oral cavity of healthy children. In this study, we report the isolation of K. negevensis strain eburonensis, initially misidentified as K. kingae with MALDI-TOF MS, from a vaginal specimen of a patient suffering of vaginosis. The genome sequencing and analysis of this strain together with comparative genomics of the Kingella genus revealed that K...
August 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28794176/molecular-tests-that-target-the-rtx-locus-do-not-distinguish-between-kingella-kingae-and-the-recently-described-kingella-negevensis-species
#2
Nawal El Houmami, Janek Bzdrenga, Guillaume André Durand, Philippe Minodier, Hervé Seligmann, Elsa Prudent, Sofiane Bakour, Stéphane Bonacorsi, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
Kingella kingae is an important invasive pathogen in early childhood. The organism elaborates a RTX toxin presumably restricted to this species. Consequently, real-time PCR (qPCR) assays targeting the RTX locus have been developed in recent years and are gaining increasing use for the molecular diagnosis of K. kingae infections. However, this study shows that Kingella negevensis, a Kingella species newly identified in young children, harbors an identical Kingella RTX locus, raising the question whether K. negevensis could be misdiagnosed as K...
August 9, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28760709/antimicrobial-susceptibility-testing-of-kingella-kingae-with-broth-microdilution-and-disk-diffusion-using-eucast-recommended-media
#3
Erika Matuschek, Jenny Åhman, Gunnar Kahlmeter, Pablo Yagupsky
OBJECTIVES: Due to the increasing use of improved culture techniques and sensitive nucleic acid amplification assays, Kingella kingae was recognized as an important cause of invasive infections in young children, especially in septic arthritis, osteomyelitis, bacteremia and endocarditis. In 2016, EUCAST established clinical MIC breakpoints for K. kingae (published in EUCAST Clinical Breakpoint Tables v 7.0, 2017). The present study was carried out to produce MIC-zone diameter correlations for K...
July 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28699877/isolation-and-characterization-of-kingella-negevensis-sp-nov-a-novel-kingella-species-detected-in-a-healthy-paediatric-population
#4
Nawal El Houmami, Sofiane Bakour, Janek Bzdrenga, Jaishiram Rathored, Hervé Seligmann, Catherine Robert, Nicholas Armstrong, Jacques Schrenzel, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
We herein report the isolation and characterization of 21 Gram-stain-negative strains cultivated from the oropharynx of healthy children in Israel and Switzerland. Initially described as small colony variants of Kingella kingae, phenotypic analysis, biochemical analysis, phylogenetic analysis based on sequencing of the partial 16S rRNA gene and five housekeeping genes (abcZ, adk, G6PD, groEL and recA), and whole genome sequencing and comparison between members of the genera Kingella and Neisseria provided evidence for assigning them to the genus Kingella...
July 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28661965/pyogenic-tenosynovitis-in-infants-a-case-series
#5
Céline Lironi, Christina Steiger, Céline Juchler, Vasiliki Spyropoulou, Eleftheria Samara, Dimitri Ceroni
Pyogenic tenosynovitis is an uncommon condition in children and there are few published case reports. We present a series of 11 cases who were treated in the Geneva's Children Hospital in the last 10 years. Kingella kingae was the main pathogen and the characteristics of infection (inflammatory indices, clinical findings and severity) are similar to other osteoarticular K kingae's infections in infants.
June 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28650419/spondylodiscitis-by-kingella-kingae-an-emerging-pathogen-in-an-older-pediatric-population
#6
Sara Alexandra Fernandes Machado, Joana Manuel Ferreira Freitas, Nuno Paulo Alegrete da Silva, Jorge Manuel Coutinho Costa Moreira, Rui Alexandre Peixoto Pinto, Fernando Gilberto de Melo Costa
In children, greater than 95% of Kingella kingae infections are diagnosed between 6 and 48 months of age. Kingella kingae has not been systematically investigated, especially in older children. We describe a case of spondylodiscitis by Kingella kingae in an 8-year-old child.
June 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28607765/paediatric-bone-and-joint-infection
#7
REVIEW
Alexios D Iliadis, Manoj Ramachandran
Despite advances in understanding and management, paediatric osteoarticular infections continue to pose diagnostic difficulties for clinicians. Delays in diagnosis can lead to potentially devastating morbidity.No single investigation, including joint aspiration, is sufficiently reliable to diagnose conclusively paediatric bone and joint infection. Diagnosis should be based on a combination of clinical signs, imaging and laboratory investigations. Algorithms should supplement, and not replace, clinical decision making in all cases...
January 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28546880/kingella-kingae-keratitis-in-a-child-with-underlying-vernal-keratoconjunctivitis
#8
Salim Nurul-Laila, Khai-Siang Chai, Ahmad Tajudin Liza-Sharmini, Ismail Shatriah
Kingella kingae had rarely been reported as a causative organism for corneal ulcer and had not been described before in vernal keratoconjunctivitis (VKC). Generally regarded as commensals of respiratory tract particularly in young children, it had however been isolated from the corneal ulcer scraping of both adult and children. We report a case of bacterial ulcer with isolation of Kingella kingae from the corneal scraping in a young child with underlying VKC.
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28539344/investigation-of-kingella-kingae-invasive-infection-outbreaks-in-day-care-facilities-assessment-of-a-rapid-genotyping-tool-targeting-the-dna-uptake-sequence
#9
Philippe Bidet, Violaine Tran Quang, Pablo Yagusky, André Birgy, Stéphane Bonacorsi, Romain Basmaci
Outbreaks of Kingella kingae invasive infections have recently been reported in day care centers. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) revealed that although the invasive strains had widespread dissemination in the day care population, less virulent strains were also circulating in the facilities. However, these typing tools are costly, time-consuming, and labor-intensive and provide delayed results. A study was conducted to assess the performance of a rapid and cost-effective genotyping tool targeting the DNA uptake sequence (DUS) in the investigation of outbreaks of K...
August 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28373088/clinical-presentation-and-treatment-of-septic-arthritis-in-children
#10
I Moro-Lago, G Talavera, L Moraleda, G González-Morán
INTRODUCTION: The aim of this study is to determine the epidemiological features, clinical presentation, and treatment of children with septic arthritis. MATERIAL AND METHOD: A retrospective review was conducted on a total of 141 children with septic arthritis treated in Hospital Universitario La Paz (Madrid) between the years 2000 to 2013. The patient data collected included, the joint affected, the clinical presentation, the laboratory results, the appearance, Gram stain result, and the joint fluid culture, as well as the imaging tests and the treatment...
May 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28317027/the-type-a-and-type-b-polysaccharide-capsules-predominate-in-an-international-collection-of-invasive-kingella-kingae-isolates
#11
Eric A Porsch, Kimberly F Starr, Pablo Yagupsky, Joseph W St Geme
Kingella kingae is an encapsulated Gram-negative bacterium and an important etiology of osteoarticular infections in young children. A recent study examining a diverse collection of carrier and invasive K. kingae isolates from Israel revealed four distinct polysaccharide capsule types. In this study, to obtain a global view of K. kingae capsule type diversity, we examined an international collection of isolates using a multiplex PCR approach. The collection contained all four previously identified capsule types and no new capsule types...
March 2017: MSphere
https://www.readbyqxmd.com/read/27956728/kingella-kingae-chest-mass-mimicking-a-tumor-in-an-11-month-old-baby
#12
Halima Dabaja-Younis, Imad Kassis, Anat Ilivitzki, Ran Steinberg, Yael Shachor-Meyouhas
Kingella kingae has been recognized as a common etiology of pediatric osteoarticular infections, especially among children younger than 5 years of age. In recent years, there have been reported cases of unusual manifestations. We report a rare case of a chest mass mimicking a tumor in an 11-month-old baby.
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27760194/kingella-kingae-expresses-four-structurally-distinct-polysaccharide-capsules-that-differ-in-their-correlation-with-invasive-disease
#13
Kimberly F Starr, Eric A Porsch, Patrick C Seed, Christian Heiss, Radnaa Naran, L Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W St Geme
Kingella kingae is an encapsulated gram-negative organism that is a common cause of osteoarticular infections in young children. In earlier work, we identified a glycosyltransferase gene called csaA that is necessary for synthesis of the [3)-β-GalpNAc-(1→5)-β-Kdop-(2→] polysaccharide capsule (type a) in K. kingae strain 269-492. In the current study, we analyzed a large collection of invasive and carrier isolates from Israel and found that csaA was present in only 47% of the isolates. Further examination of this collection using primers based on the sequence that flanks csaA revealed three additional gene clusters (designated the csb, csc, and csd loci), all encoding predicted glycosyltransferases...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27745829/-treatment-and-progression-of-acute-communautary-osteoarticular-infections-in-healthy-children-a-retrospective-monocentric-study-of-64%C3%A2-patients
#14
A Lemoine, F Baudin, R Vialle, E Grimprel
INTRODUCTION: The prognosis of osteoarticular infections has improved over the past 20 years but it still remains potentially severe. The treatment of these infections has been simplified and shortened. In 2008, the Pediatric Infectious Disease Group (GPIP) established new therapeutic guidelines in order to standardize treatment in France. The aim of this study is to analyze practices in a Parisian hospital and assess the efficacy of this treatment in short and medium terms. MATERIALS AND METHODS: This retrospective study focused on patients older than 3 months, without comorbidities, who were hospitalized for an acute osteoarticular infection in 2012 at Trousseau Hospital (Paris), with a follow-up of at least 4 weeks...
November 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27714987/in-vitro-characterization-of-biofilms-formed-by-kingella-kingae
#15
J B Kaplan, V Sampathkumar, M Bendaoud, A K Giannakakis, E T Lally, N V Balashova
The Gram-negative bacterium Kingella kingae is part of the normal oropharyngeal mucosal flora of children <4 years old. K. kingae can enter the submucosa and cause infections of the skeletal system in children, including septic arthritis and osteomyelitis. The organism is also associated with infective endocarditis in children and adults. Although biofilm formation has been coupled with pharyngeal colonization, osteoarticular infections, and infective endocarditis, no studies have investigated biofilm formation in K...
August 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/27669685/low-prevalence-of-kingella-kingae-carriage-in-children-aged-6-48-months-in-sydney-australia
#16
Ameneh Khatami, Braden Rl Rivers, Alexander C Outhred, Alison M Kesson
AIM: A prospective observational study was conducted to estimate the prevalence of oropharyngeal carriage of Kingella kingae in healthy Australian pre-school children. METHODS: Screening for carriage of K. kingae as well as Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Haemophilus influenzae, and K. kingae was undertaken using a single bacterial throat swab taken from well children aged 6 months to 4 years. Standard laboratory procedures were used for culture and identification of organisms...
September 27, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27639784/unusual-case-of-paediatric-septic-arthritis-of-the-lumbar-facet-joints-due-to-kingella-kingae
#17
M Le Hanneur, C Vidal, C Mallet, K Mazda, B Ilharreborde
A 32-month-old boy presented with febrile limping that had developed over 6days, associated with right lumbosacral inflammatory swelling. Magnetic resonance imaging (MRI) showed joint effusion of the right L5-S1 zygapophyseal joint, complicated by destructive osteomyelitis of the L5 articular process and paraspinal abscess. Surgery was decided to evacuate the fluid accumulation and rule out differential diagnoses. The diagnosis of septic arthritis of the facet joint was confirmed intraoperatively; real-time quantitative PCR analysis identified Kingella kingae...
September 14, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27586302/high-rate-of-oropharyngeal-kingella-kingae-carriage-in-new-zealand-children
#18
Laudi Olijve, Roslyn Podmore, Trevor Anderson, Tony Walls
AIM: This study aimed to describe the burden of disease and estimated rates of oropharyngeal carriage of Kingella kingae among New Zealand children. We compared polymerase chain reaction (PCR) and culture for the detection of this microorganism with a view to further development and implementation of K. kingae PCR in Christchurch Hospital. METHODS: Oropharyngeal swabs from children between 6 and 48 months of age were analysed by culture to estimate carriage rates of K...
December 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27420804/identifying-reservoirs-of-infections-caused-by-kingella-kingae-a-case-control-study-of-oropharyngeal-carriage-of-k-kingae-among-healthy-adults
#19
Gabriel Brändle, Vasiliki Spyropoulou, Albane B R Maggio, Rebecca Anderson de la Llana, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano, Dimitri Ceroni
BACKGROUND: Kingella kingae is currently recognized as a significant pathogen of the pediatric population. Nevertheless, the possibility for adults to serve as a reservoir of healthy carriers has not been studied. METHOD: We conducted a monocentric transversal study on 228 healthy adults to define the carriage rate. Participants were recruited among the staff of a children's hospital, a population exposed to aerosolized droplets from children. A secondary analysis using a case-control method was conducted to assess risk factors for carriage...
August 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27408498/spinal-infections-in-children-a-review
#20
REVIEW
Rahul Tyagi
Spinal infections are uncommon but significant causes of morbidity and hospitalization in the paediatric population. These infections encompass a broad range of conditions, from discitis to osteomyelitis and spinal epidural and intramedullary abscesses. Paediatric spinal infections can be caused by a range of bacterial, viral, fungal and parasitic agents. Ultrastructural differences of the vertebrae and associated structures result in distinct mechanisms of pathogenesis of spinal infections in children compared to adults...
December 2016: Journal of Orthopaedics
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