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JOURNAL ARTICLE
Maria V Dimou, Paraskevi Xepapadaki, John Lakoumentas, Leonardos Mageiros, Xenophon Aggelidis, Maria Antonopoulou, Petros Bakakos, Sophia Βotskariova, Konstantinos Chliveros, Spyridon Chrysoulakis, Dionysios Dimas, Nikolaos Douladiris, Mina Gaga, Christos Grigoreas, Lampros Kalogiros, Michael Katotomichelakis, Evangelia Kompoti, Jannis Constantinidis, Zoi Koutsogianni, Stelios Loukides, Michael Makris, Emmanouil Manousakis, Pavlos Marangoudakis, Maria Marmara, Nikolaos Mikos, Paraskevi Mitsakou, Dimitrios Mitsias, Aris Pagalos, Vasilios Papanikolaou, Ioannis Paraskevopoulos, Constantinos Pitsios, Fotis Psarros, Nikoletta Rovina, Konstantinos Samitas, Evaggelia Stefanaki, Mina Vallianatou, Dimitrios Vourdas, Ioanna Tsiligianni, Jean Bousquet, Nikolaos G Papadopoulos
BACKGROUND: Allergic rhinitis (AR) is a common respiratory disease encompassing a variety of phenotypes. Patients can be sensitized to one or more allergens. There are indications that polysensitization is associated with more severe disease. However, the extent to which the level of sensitization is associated to clinical disease variability, underlying the distinct nature of AR from AR+ conjunctivitis or AR+ asthma, is not known. OBJECTIVE: The aim of this study was to evaluate phenotypical differences between mono- and poly-sensitized patients with AR and to quantify their symptomatic variability...
April 26, 2024: Annals of Allergy, Asthma & Immunology
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JOURNAL ARTICLE
Saroj Kumari Meena, Rajnish Gupta, Manmohan Puri
Asthma and obstructive sleep apnea (OSA) are commonly prevalent diseases, and both can co-exist to result in an alternate overlap syndrome, where a bidirectional relationship can adversely affect each other. This study aimed to determine the existence and pattern of sleep-related breathing disorders in subjects with bronchial asthma. It was prospectively conducted at the National Institute of Tuberculosis and Respiratory Diseases, New Delhi, in diagnosed cases of bronchial asthma. A subjective assessment of sleepiness was done using the Epworth sleepiness scale (ESS)...
April 23, 2024: Monaldi Archives for Chest Disease
#3
JOURNAL ARTICLE
Fan Zhang, Jiashun Liao, Yuan Qian, Xinyu Niu, Jia Wei, Man Li, Duyi Guo, Peiqiu Zhu
INTRODUCTION: The purpose of this study was to assess the clinical effectiveness and safety profile of omalizumab as a therapeutic intervention for chronic urticaria (CU). METHODS: From March 1, 2023, to September 30, 2023, data on a cohort comprising 96 patients with CU, who underwent treatment with omalizumab at our medical institution's allergy clinic, were systematically compiled. Subsequent to the administration of omalizumab, the therapeutic efficacy was assessed utilizing the 7-day urticaria activity score and the urticaria control test...
March 21, 2024: International Archives of Allergy and Immunology
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JOURNAL ARTICLE
Mohamad Abuzakouk, Osama Yousef, Monica Fahmy, Zahir Chouikrat
BACKGROUND: Data on eosinophilic gastrointestinal disorders (EGIDs) are limited in the United Arab Emirates. OBJECTIVE: This study aimed to describe the distribution of eosinophilic gastritis/gastroenteritis (EoG/EGE) and eosinophilic esophagitis (EoE) among patients whose data are recorded on the Cleveland Clinic Abu Dhabi (CCAD) systems. METHODS: Anonymized aggregate data were obtained from the Clinerion Patient Network Explorer (PNEx® ) network installed at the CCAD on patients diagnosed with EoG/EGE (n=17, of whom 11 (64...
January 2024: Curēus
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JOURNAL ARTICLE
Patricia Margaritte-Jeannin, Raphaël Vernet, Ashley Budu-Aggrey, Markus Ege, Anne-Marie Madore, Christophe Linhard, Hamida Mohamdi, Erika von Mutius, Raquell Granell, Florence Demenais, Cathrine Laprise, Emmanuelle Bouzigon, Marie-Hélène Dizier
PURPOSE: Numerous genes have been associated with allergic diseases (asthma, allergic rhinitis, and eczema), but they explain only part of their heritability. This is partly because most previous studies ignored complex mechanisms such as gene-environment (G-E) interactions and complex phenotypes such as co-morbidity. However, it was recently evidenced that the co-morbidity of asthma-plus-eczema appears as a sub-entity depending on specific genetic factors. Besides, evidence also suggest that gene-by-early life environmental tobacco smoke (ETS) exposure interactions play a role in asthma, but were never investigated for asthma-plus-eczema...
November 2023: Allergy, Asthma & Immunology Research
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REVIEW
Hassan H Ramadan
PURPOSE: An up-to-date overview of diagnosis, differential diagnosis, comorbidities, and current medical and surgical management of pediatric chronic rhinosinusitis (PCRS). METHODS: Review of current evidence-based literature on PCRS. RESULTS: Diagnosis of PCRS seems to be improving based on recent evidence using nasal endoscopy as well as computed tomography scanning. Recent literature supports the fact that chronic adenoiditis can be an independent etiology of symptoms of chronic sinusitis, that are very similar to chronic adenoiditis...
March 2024: European Archives of Oto-rhino-laryngology
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JOURNAL ARTICLE
Joemol John, Nishanth Savery, Prabu Velayutham, Mathan K, Prem Davis
Introduction Allergic rhinitis is one of the most common diseases in the world. It affects all people irrespective of age, sex and race. Allergic rhinitis leads to the development of social and interpersonal problems and loss of productivity which in turn causes depression. The depression was an underestimated iceberg phenomenon in allergic rhinitis patients. Objective The study evaluates the association between the severity of allergic rhinitis and the level of depression in patients attending tertiary care hospitals in south India...
May 2023: Curēus
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JOURNAL ARTICLE
Matineh Nirouei, Mona Kouchekali, Homa Sadri, Mostafa Qorbani, Hadi Montazerlotfelahi, Narges Eslami, Marzieh Tavakol
BACKGROUND: Asthma is the most prevalent respiratory disease caused by chronic airway inflammation. Attention Deficit Hyperactivity Disorder (ADHD) is children's most common psychological and neurodevelopmental disorder. Increased risk for ADHD in patients with inflammatory and autoimmune diseases supports the role of inflammatory mechanisms in the occurrence of ADHD. However, the association between asthma and ADHD remains unclear. OBJECTIVE: This study was designed to evaluate the prevalence of ADHD in patients with asthma who were referred to the clinic of allergy and clinical immunology...
June 27, 2023: Clinical and Molecular Allergy: CMA
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David E Ochayon, Stanley B DeVore, Wan-Chi Chang, Durga Krishnamurthy, Harsha Seelamneni, Brittany Grashel, Daniel Spagna, Sandra Andorf, Lisa J Martin, Jocelyn M Biagini, Stephen N Waggoner, Gurjit K Khurana Hershey
Atopic dermatitis (AD) is a chronic inflammatory skin disease that often precedes the development of food allergy, asthma, and allergic rhinitis. The prevailing paradigm holds that a reduced frequency and function of natural killer (NK) cell contributes to AD pathogenesis, yet the underlying mechanisms and contributions of NK cells to allergic co-morbidities remain ill-defined. Herein, analysis of circulating NK cells in a longitudinal early life cohort of children with AD revealed a progressive accumulation of NK cells with low expression of the activating receptor NKG2D, which was linked to more severe AD and sensitivity to allergens...
June 5, 2023: medRxiv
#10
REVIEW
Xuwen Yang, Kian Fan Chung, Kewu Huang
BACKGROUND AND OBJECTIVE: Chronic cough is one of the commonest complaints requiring medical attention that significantly impacts on the patient's quality of life. In this review, we focus on chronic cough prevalence, risk factors, and health burden among the general adult population based on recent reports, which will be helpful for a better understanding of the global burden of chronic cough. METHODS: A narrative search of Medline was performed for articles and their lists of references published using the keywords "chronic cough", "chronic bronchitis", "epidemiology", "prevalence", "risk factor", "burden", "quality of life", "adult" and "general population"...
April 28, 2023: Journal of Thoracic Disease
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REVIEW
Anastasiia Allenova, Razvigor Darlenski
Atopic dermatitis (AD) as a chronic inflammatory systemic condition is far more than skin deep. Co-morbidities such as asthma and allergic rhinitis as well as the psychological impact influence seriously the quality of life of the patients. Recent studies have shown that only 10% of atopic patients undergo full manifestation of the atopic march, while 40% demonstrate concomitant food allergy. Exposure to food allergens in the environment causes sensitization and food allergy through the disruption of the skin barrier, as in AD...
February 10, 2023: Asthma Research and Practice
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Eva Moennig, Stephan Traidl
Atopic dermatitis (AD) is a common inflammatory skin disease, which negatively impacts the individual's quality of life (QoL). In particular, moderate-to-severe AD is frequently difficult to treat. We report a case involving a 40-year-old male who has suffered from AD since early childhood and who also had co-morbid seasonal allergic rhinitis. In June 2021, we initiated treatment with the fully human IgG4 monoclonal antibody tralokinumab that specifically targets IL-13 and the patient has been followed for 38 weeks...
2022: Clinical, Cosmetic and Investigational Dermatology
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JOURNAL ARTICLE
Farah L Lokman, Bee See Goh
Adenotonsillectomy is the commonest otorhinolaryngology surgery for paediatrics. The purpose of this study was to determine the safety and outcome of adenotonsillectomy in a tertiary center in Malaysia. This was achieved by studying the demographics, indications, co-morbidities of patients and its association with the complications of the procedure. This retrospective study was conducted from November 2011 until October 2016. Medical records of patients aged 2-12 years old who had adenotonsillectomy done in our center were retrieved for data collection...
October 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
#14
REVIEW
Vibha Szafron, Aikaterini Anagnostou
BACKGROUND: Peanut oral immunotherapy (POIT) has emerged as an active management option for peanut allergy, with an FDA-approved product now available for therapy. Allergic reactions, including anaphylaxis, can occur during therapy and their management is key in optimizing this treatment and patient outcomes. PURPOSE OF REVIEW: In this manuscript, we will review the rates of allergic reactions and anaphylaxis in seminal peanut oral immunotherapy research studies...
January 2023: Current Allergy and Asthma Reports
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JOURNAL ARTICLE
Aljuaid Eidha Fawzan, Sara Ahmad Assiri, Raad M M Althaqafi, Atheer Alsufyani, Ahmad Saeed A Alghamdi
Background: Allergic rhinitis (AR) is characterized by mucosal inflammation that leads to a variety of symptoms, such as nasal congestion, rhinorrhea, and sneezing. This rhinitis is triggered by inhalation of allergens, such as pollen, and this condition has a negative impact on the quality of life. AR was shown to be associated with a number of co-morbidities, including hypothyroidism, asthma, and chronic sinusitis. Objective: This study aimed to assess AR-associated comorbidities in patients presenting symptoms and paranasal sinus computed tomography (CT) scan findings in Taif City, Saudi Arabia...
September 2022: World Journal of Otorhinolaryngology—Head and Neck Surgery
#16
REVIEW
Punita Ponda, Tara Carr, Matthew A Rank, Jean Bousquet
Chronic rhinitis encompassing both allergic and nonallergic rhinitis affects a significant portion of the population worldwide, having a great impact on patient quality of life, and associated comorbid conditions, with an important societal economic burden. Allergists are often the first to evaluate and treat allergic and nonallergic rhinitis, addressing the individual triggers of the disease as well as the patient-specific responses to these triggers. This review focuses on the advances that have been made in the diagnosis, management, and treatment of nonallergic and allergic rhinitis over the past 10 years, including specific allergen immunotherapy, care pathways, and digital health...
January 2023: Journal of Allergy and Clinical Immunology in Practice
#17
JOURNAL ARTICLE
Julia Sessions, Natasha Purington, Yiwen Wang, Sean McGhee, Sayantani Sindher, Alka Goyal, Nasim Khavari
Background: Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease characterized by eosinophil inflammation of the esophagus. It has been described as a component of the Allergic March and is often seen with other atopic diseases. Some atopic diseases, including asthma, are known to be heterogenous with endotypes that guide treatment. Similarly, we propose that EoE is a heterogenous disease with varying phenotypes and endotypes that might impact response to therapy...
2022: Front Allergy
#18
JOURNAL ARTICLE
Hung-Chang Tsui, Steven Ronsmans, Peter H M Hoet, Benoit Nemery, Jeroen A J Vanoirbeek
BACKGROUND: Occupational asthma (OA) may have different etiologies, but it is not clear whether the etiologic agents influence the clinical presentation, especially the co-occurrence of skin lesions. OBJECTIVE: The aim of this study was to determine the impact of different asthmagens on the characteristics of OA, with a focus on the occurrence of prior or concomitant skin disorders. METHODS: In a retrospective analysis of patients who visited the Occupational and Environmental Disease Clinic of a tertiary referral hospital from 2009 to 2019, we classified patients into definite, probable or possible OA according to prespecified diagnostic guidelines...
May 25, 2022: Journal of Allergy and Clinical Immunology in Practice
#19
JOURNAL ARTICLE
Ayisha Kausar, Nadia Akhtar, Nighat Akbar
BACKGROUND: Allergic conjunctivitis is a common ocular disease which not only affects vision but can also compromise the quality of life of patients to a greater extent. If it is not properly managed it can lead to decreased vision due to corneal complications. This study was conducted to evaluate the epidemiological aspects of allergic conjunctivitis. METHODS: This cross-sectional study was carried out in the Ophthalmology department of Federal General Hospital, from June 2018 to June 2020...
2022: Journal of Ayub Medical College, Abbottabad: JAMC
#20
JOURNAL ARTICLE
Hossein Esmaeilzadeh, Mehrdad Eskandarisani, Hesamedin Nabavizadeh, Soheila Alyasin, Mouhebat Vali, Negar Mortazavi
Introduction: Chronic spontaneous urticaria (CSU) is a common skin allergic reaction with an unknown mechanism. There is inadequate evidence to support the role of aeroallergen sensitization in CSU. Aim: The present study was conducted to investigate the association between the aeroallergen sensitivity and CSU. Material and methods: In this cross-sectional study, 91 patients with CSU were recruited. Information on demographic characteristics was collected...
February 2022: Postȩpy Dermatologii i Alergologii
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