Qian Wang, Wen-Zhi Cai, Qin-Rong Wang, Ming-Qing Zhu, Ling-Zhi Yan, Yan Yu, Xie-Bing Bao, Hong-Jie Shen, Hong Yao, Jun-Dan Xie, Tong-Tong Zhang, Ling Zhang, Xiao-Yu Xu, Zhe Shan, Hong Liu, Jian-Nong Cen, Dan-Dan Liu, Jin-Lan Pan, Da-Ru Lu, Jia Chen, Yang Xu, Ri Zhang, Ying Wang, Sheng-Li Xue, Miao Miao, Yue Han, Xiao-Wen Tang, Hui-Ying Qiu, Ai-Ning Sun, Jin-Yan Huang, Hai-Ping Dai, De-Pei Wu, Su-Ning Chen
Mixed phenotype acute leukemia (MPAL) is a subtype of leukemia in which lymphoid and myeloid markers are co-expressed. Knowledge regarding the genetic features of MPAL is lacking due to its rarity and heterogeneity. Here, we applied an integrated genomic and transcriptomic approach to explore the molecular characteristics of 176 adult patients with MPAL, including 86 patients with T-lymphoid/myeloid MPAL (T/My MPAL-NOS), 42 with Ph+ MPAL, 36 with B-lymphoid/myeloid MPAL (B/My MPAL-NOS), 4 with t(v;11q23), and 8 with MPAL, NOS, rare types...
October 11, 2022: American Journal of Hematology